ライフサイエンスコーパス: question of how

1 specificity are counterselected, raising the question of how 4E10 was generated in the patient from w

2 behaviour in multi-cellular organisms is the question of how a cell exits one transcriptional state t

3 Our discovery raised the question of how a cell undergoing genome reduplication m

4 This work resolves an open question of how a key class of suspension-feeding organi

5 This opens the question of how a large subset of American states might

6 ness and self-renewal potential, raising the question of how a mutant HSC can sustainably outcompete

7 Here, we address the question of how a PAL can function as a ligase rather th

8 This observation raises the interesting question of how a replicative DNA polymerase is able to

9 These observations beg the question of how a single amino acid mutation may have su

10 The question of how a single protein modulates many distinct

11 ebiotic RNA synthesis reactions, raising the question of how a single sequence could serve as both a

12 tissue-specific roles for ILCs; however, the question of how a small population has large effects on

13 The question of how a vapor-liquid interface affects freezin

14 ial hydrogen peroxide (H2O2), leading to the question of how Aa deals with this potent antimicrobial

15 This discrepancy begs the question of how AAV2 and HSV-1 can coexist in a cell pop

16 This raises the key question of how ABA signaling arose in the earliest land

17 tors are known for OMM insertion, posing the question of how accuracy is achieved.

18 This raises the question of how actin polymerization occurs at the integ

19 This study reopens the question of how adenovirus enters cells in vivo.

20 This raises the question of how adhesion assembly occurs against opposit

21 The question of how allostery works was posed almost 50 year

22 We focus on the challenging questions of how allostery can both cause disease and co

23 We apply this technology to the question of how and when Mus81-Mms4 and Yen1 nucleases a

24 and the number of hominin species grows, the question of how and when the modern human face originate

25 have not been used systematically to address questions of how and why we age.

26 a simple water-filled pore, which raises the question of how anomalous water behavior affects the mec

27 olutely require kinase activity, raising the question of how Arg might modulate actin assembly and tu

28 Our structure answers the key questions of how ATP hydrolysis leads to linker remodell

29 o bacteria, in particular with regard to the question of how bacteria generate and coordinate forces

30 the conducting bulk, providing input to the question of how ballistic transport may be limited in th

31 However, the question of how barites were able to precipitate from a

32 y multiparameter time series and raising the question of how best to extract insights from such rich

33 The increasing use of TRT raises the question of how best to integrate TRT into multimodality

34 cases of donor-derived infections raise the question of how best to screen donors without excessive

35 rs and educators have long wrestled with the question of how best to teach their clients be they huma

36 movement ecology, are vast, but the crucial questions of how best to match the most appropriate sens

37 Conflicting findings led to questions of how best to study the role of this variant

38 The fundamental question of how bone quality is affected in AIS remains

39 eration in different cell types, raising the question of how broadly mTOR regulates axonal regrowth a

40 f CCV biogenesis while raising the important question of how C. burnetii obtains essential nutrients

41 The question of how cell division orientation is determined

42 This raises the question of how cells orchestrate the timing of multiple

43 Here we tackle the question of how cells process combinatorial signals by m

44 l system in which to investigate the general question of how cells regulate organelle size.

45 on can be substantially stochastic poses the question of how cells respond to dynamic environments us

46 tanding biofilm development, the fundamental question of how cells sense the environmental cues that

47 e use neural crest (NC) cells to address the question of how cells that have down-regulated cell-cell

48 Here, we examine the general question of how cells use Ca(2+) pulses to encode input

49 We addressed the questions of how cerebral glucose transport and phosphor

50 Thus, the question of how certain arrangements of such functions o

51 enomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated.

52 They allow focus to be placed solely on the question of how changes in amino acid side-chain orienta

53 Herein we address the question of how cholesterol crystal formation occurs in

54 romatin states in gene regulation, but a key question of how chromatin state segmentations vary under

55 gement balanced by fewer spines, raising the question of how clusters form despite this homeostatic r

56 hbours are observed, and poses a fundamental question of how complex interactions on the triangular l

57 The main focus lay on the question of how complex object use compared with unspeci

58 Here we address the question of how conductance ratios are affected by elect

59 opulations and immigrant groups, raising the question of how conflict can be overcome.

60 rch has focused on group-living species, the question of how cooperation can first be favored in soli

61 several PCs at the same position raised the question of how developmental time controlled muscle ide

62 ry centers in bilateral animals presents the question of how different brain structures, such as the

63 Here, the intriguing question of how diffusion evolves in a single nanopartic

64 Here, we address the fundamental question of how dimensionality is related to connectivit

65 umption of an animal meal, we here asked the question of how Dionaea sequesters prey-derived potassiu

66 tion are expressed in gradients, raising the question of how discrete domains are generated.

67 across distantly related plants, raising the question of how diverse inflorescence architectures aris

68 ions, provides a tantalizing solution to the question of how diverse life can survive glaciations.

69 Considerable interest surrounds the question of how DNA glycosylases translocate efficiently

70 However, the question of how DNA is folded and the influence of such

71 DPP signaling but also highlight outstanding questions of how DPP coordinates patterning and growth d

72 This leads to the question of how each segment of lymphatic vessel respond

73 The question of how each tradition can learn from the other

74 reaching the CNS [3], our finding raised the question of how ecdysone enters the CNS through the BBB

75 We address the questions of how egg-associated cues elicit plant defens

76 s lack of neurogenesis leaves unanswered the question of how enteric neuronal populations are maintai

77 standing of plant growth and adaptation, the question of how environment-induced plastic response is

78 These findings raise the question of how enzymes with such different evolutionary

79 of p38 MAP kinase, which posed the important question of how Epac2 engages p38 without simultaneously

80 ium entry (SOCE) regulation, the fundamental question of how ER morphology affects this process remai

81 osylase has not been identified, raising the question of how extracytoplasmic proteins are repaired a

82 e genitals has always been acknowledged, the question of how far these categories extend into human b

83 In order to address the question of how flavonoids affected root nodulation of f

84 they explored a large arena, focusing on the question of how flies remain near the food.

85 However, the fundamental question of how force regulates actin dynamics is unclea

86 Over a decade of studies have tackled the question of how FtsK/SpoIIIE translocases establish and

87 hin a common nondelimited space, raising the question of how functional compartmentalization of gene

88 mic data on human cancers poses the critical question of how genomic variations translate to cancer p

89 The question of how global cognitive factors affect correlat

90 n shown to worsen heart failure, raising the question of how glucose mediates protective versus detri

91 dividuals, particularly when it comes to the question of how group-level traits are inherited or tran

92 We set out to address the fundamental question of how gut microbes and nutrition, key regulato

93 in Hippo regulation, thus addressing the key question of how Hippo signalling is initiated and sugges

94 ut not all non-bilaterian phyla, raising the question of how Hox-TALE interactions evolved to provide

95 This raises the question of how human cells detect and respond to T. gon

96 uasive health messaging and speak to broader questions of how humans make decisions about how to beha

97 In the present study, we address the question of how hyperoxia-induced alterations in WM deve

98 se features of the B-cell response raise the question of how important antibody fine-specificity is f

99 Specifically, the question of how individual object information is represe

100 This leads to the question of how individuals differ in their gaze behavio

101 The question of how individuals in a population organize whe

102 These findings raise basic questions of how innate odor valence is extracted from o

103 To further investigate the question of how internal symmetry evolved, how symmetry

104 We applied this system to the crucial question of how intracellular Amyloid-beta oligomers und

105 ance or limit hyperpolarization, raising the question of how intrinsic conductances shape pauses in d

106 e fitness of bacterial colonies, raising the question of how it is regulated.

107 let by its lipidated N terminus, raising the question of how it monitors LPS.

108 The complexity of this network begs the questions of how it originated and what selective pressu

109 between them and contributes to the central question of how language evolves.

110 We address the question of how large a molecular object may become by g

111 imit of 39 nanometres(4-7), which raises the question of how larger cytoplasmic molecules are cleared

112 ively at depolarized potentials, raising the question of how lidocaine-like compounds affect neurons

113 ligands secreted 50 microm away, raising the question of how long-distance Wg spreading occurs.

114 into clinical practice and will address core questions of how low LDL cholesterol can be safely reduc

115 approach allows a more explicit test of the question of how macroevolutionary factors shape not just

116 In this study, we address the question of how many and what types of noncovalent inter

117 The question of how many chains an elementary cellulose micr

118 in a gender-specific fashion and raises the question of how many maternal antibodies affect brain de

119 he human body continues to grow, raising the question of how many more species have yet to be identif

120 These observations prompt the question of how many proteins can undergo liquid-liquid

121 Threshold-seq addresses the critical question of how many reads need to support a short RNA m

122 ht into Plasmodium evolution and raising the question of how many species there are.

123 estrial vertebrates have been described, the question of how many terrestrial species exist is all bu

124 vious research is directly applicable to the question of how many US infants with CCHD might be ident

125 The question of how MCs contribute to human disease has been

126 The question of how mechanically gated membrane channels ope

127 high degree of lipid order, which raises the question of how membrane proteins function in such an en

128 ulators, and we briefly discuss current open questions of how metalloregulators function in bacterial

129 and unique perspectives to help us solve the question of how microorganisms methylate mercury.

130 To address the critical question of how MSCs loaded with oncolytic viruses affec

131 These data help to clarify the long-standing question of how MT-4 cells overcome the requirement for

132 tive to reduce bleeding in hemophilia A, the question of how much clotting is enough is at the forefr

133 This outcome prompts the question of how much dystrophin restoration is sufficien

134 The second section primarily focuses on the question of how much low-density lipoprotein cholesterol

135 house gas emissions have ceased, raising the question of how much sea-level commitment is expected fo

136 lity has been rarely tested, leaving an open question of how much the findings from humans imply evol

137 The question of how much uncertainty on mixture composition

138 This raises the interesting question of how mutator hitchhiking is suppressed or its

139 Here we address the question of how n-octadecylsilane (OTS)-derived self-ass

140 This poses the question of how NBP35 (Nucleotide-Binding Protein 35 kDa

141 To investigate the fundamental question of how nervous systems encode, organize, and se

142 ilaterian nervous systems but also raise the question of how neural circuit compositions and architec

143 An outstanding open question of how neural coding supports Bayesian inferenc

144 temporal cortex ("face patches") raises the question of how neural selectivity for faces is organize

145 ic temperature sensitivity, which raises the question of how neurons and neuronal circuits can operat

146 This fact raises the question of how NK cells expressing such activating rece

147 The question of how noncoding RNAs are involved in Polycomb

148 m, nuclei divide asynchronously, raising the question of how nuclear timing differences are maintaine

149 e to iron leakage from the core, raising the question of how (*)OH-mediated damage to Dps-1-bound DNA

150 tuned blue using exogenous ligands, but the question of how one can create a self-contained blue cop

151 This raises the question of how one transcription factor can be activate

152 However, the question of how other cell types may cooperate within th

153 s log singularity is suppressed, raising the question of how pairing occurs in the absence of a Fermi

154 nt decisions may be informed by attention to questions of how (pathways) and for whom (predisposition

155 the present research examines the important question of how patients and advisees in general react t

156 d herein address conclusively the intriguing question of how PBDEs form PBDD/Fs, a matter that has be

157 in motor axon growth and they highlight the question of how PCP proteins, which form cell-cell compl

158 ssing current models to the still unresolved question of how piRNA precursors are selected and channe

159 deaf individuals.SIGNIFICANCE STATEMENT The question of how pitch is represented in the ear has been

160 This raises the important question of how plasticity is coordinated across the net

161 esis by archaeal KEOPS in vitro, raising the question of how precisely Pcc1-mediated dimerization imp

162 This raises the question of how protein-protein interaction specificity

163 from the site of ligand binding, raising the question of how proteolytic sensitivity is achieved.

164 ensing regulated cooperation, which begs the question of how quorum sensing systems are maintained in

165 Here we address the question of how rapidly multiple drivers of marine ecosy

166 We address the question of how recent changes in ocean conditions will

167 performance of behavioral tasks, raising the question of how recorded activity relates to theoretical

168 ion of reductants and ligands has raised the question of how redox reactions might affect ligand-cont

169 The question of how resting-state functional connectivity (F

170 evel functional specialization, leads to the question of how rodents would perform on a categorizatio

171 ls and accumulate as cells grow, raising the questions of how SBF/MBF are dynamically distributed acr

172 d GTP-bound forms of the factor, raising the question of how SelB can fulfill its delivery function.

173 Here, we address the question of how senescence is induced in rarely dividing

174 l muscle spindles in face muscles raises the question of how sensory input from the face is used to c

175 We consider the question of how sensory networks enable the detection of

176 TER is useful to the community to answer the question of how sequence mutations affect the function o

177 of chromatin modifying proteins, but the key question of how SHP transduces BA signaling into repress

178 nt for tumor development, thus prompting the question of how single mutant cells give rise to neoplas

179 ent years by a number of publications is the question of how skewed allelic expression should be for

180 EAA supplementation is important because the question of how some detritivores are able to subsist on

181 emselves mediate synaptogenesis, raising the question of how SPARCL1 enhances synapse formation by bi

182 ce of one gene on distinct phenotypes-raises questions of how specific genes and their protein produc

183 Here we address the central questions of how stable isotropic growth of a branch at

184 A new paper in Cell addresses the important question of how STING-dependent signaling is normally co

185 ich body of empirical work has addressed the question of how stress changes the way we memorize, lear

186 resent only in the Pancrustacea, raising the question of how Su(H) in other protostomes gains repress

187 0s; its abrupt extinction in 1914 raises the question of how such an abundant bird could have been dr

188 ically induces similar movement, raising the question of how such chemical modifications are balanced

189 This raises the question of how such cooperation can arise from natural

190 ain in its proximal tail region, raising the question of how such divergent motors perform the same f

191 This poses the crucial question of how such neurons can produce stable activity

192 study was designed to answer the fundamental question of how such NPs are distributed in an in vivo m

193 ision theory, shining a new light on the old questions of how such judgments are formed.

194 a temporally delayed reward, which poses the question of how synaptic activity patterns associate wit

195 ntacts.SIGNIFICANCE STATEMENT To address the question of how synaptic connectivity is established dur

196 The question of how systemic IgG antibodies neutralize toxin

197 mic input in sensory areas, which raises the question of how thalamocortical synapses formed in M1 in

198 This opinion article explores the question of how the active X is protected from silencing

199 spheric season occurred in 2011, raising the question of how the Arctic ozone chemistry in that year

200 This raises the question of how the beetles combine multimodal orientati

201 that has so far been neglected concerns the question of how the brain forms attentional expectancies

202 e increasingly turned their attention to the question of how the brain implements decisions between d

203 Here we address the question of how the Cdk1 cell cycle oscillator changes b

204 The question of how the densely packed proteins of the inner

205 s heterogeneous methylomes, thus raising the question of how the DNA methylome remains stable despite

206 This unusual inhibitory mechanism raises the question of how the drug imposes sequence selectivity on

207 e oligomeric nature of many aaRSs raises the question of how the functioning and oligomerization of d

208 n male and female alligators leaves open the question of how the genes responsible for sex determinat

209 This raises the question of how the gonococcus infects men if N-acetylla

210 is crucial in overcoming this challenge, the question of how the nanoscale properties of the plant ce

211 These observations raise the important question of how the nervous system processes multiple so

212 Fourth, we discuss the question of how the network approach should incorporate

213 Here, we investigated the question of how the neuronal cytoskeleton protects axons

214 known to be a nuclear protein, prompting the question of how the nuclear NAD(+) pool is maintained an

215 or the macrophage and raises the fundamental question of how the phagocytic cell optimizes the acidif

216 elative to, the rat's head, which raises the question of how the rat might determine the position and

217 des important insights into the longstanding question of how the receptor transduces signals initiate

218 ene expression and resolve the long-standing question of how the RNA genome is transported to the ass

219 ale connectivity, providing insight into the question of how the scales of micro-organization and mac

220 Here we address the question of how the Short-root (SHR) proteins from Arabi

221 In this work, we address the question of how the spectral width of the light source a

222 re-former and we have used it to address the question of how the spore coat is assembled from multipl

223 We tackled the question of how the strain and biochemical makeup of alg

224 In this study, we have addressed the question of how the T cell repertoire changes as a funct

225 In this review, we address the question of how the tip-growing pollen tube achieves its

226 s a second set of body flaps and reopens the question of how the two branches of arthropod legs evolv

227 In the present study we addressed the question of how the unit sized linear mtDNA of Candida p

228 he skin is one target tissue of HSV, and the question of how the virus overcomes the protective skin

229 While the question of how the visual system detects and senses mot

230 Here, we address the question of how the visual system identifies the dispari

231 avioral experiment in humans) to address the question of how the visual system maximizes behavioral s

232 shift in the focus of future research to the question of how the visuo-perceptual system represents a

233 orted, and address the important fundamental question of how the work function of small supported met

234 ptide fragments from ssDNA ends, raising the question of how the ~90 kDa TOP1 protein is processed up

235 neural circuits have been proposed, but many questions of how the architecture of visual neuropils ev

236 This raises questions of how the formation of toxic protein species

237 This raises questions of how the important embryonic and postnatal f

238 o functional sensory structures, raising the question of how their development is coordinated.

239 r-rich food most of their lives, raising the question of how these animals modulate food-seeking beha

240 lacks a DNA-binding domain which raises the question of how these bacteria regulate the synthesis of

241 y the sensory detection of food, raising the question of how these cells can promote feeding at all.

242 activation states has raised the fundamental question of how these cells, normally essential for syna

243 ers lipid metabolism, raising the intriguing question of how these effects might be related.

244 ht assembly on the trains [3], provoking the question of how these motors coordinate their action to

245 res that are in the ER membrane, raising the question of how these nascent LDs bud from the ER as the

246 This raises the question of how these pathways interact to support conte

247 nse in terms of host defense, but raises the question of how these remarkable cells balance both thes

248 the encoded amino acid sequence, raises the question of how these signals and overlapping codes are

249 et of Esx, PE, and PPE proteins, raising the question of how these substrates are recognized in a sys

250 However, the central question of how these sugars are perceived in the contex

251 ence of two enzymes in one complex poses the question of how these two enzymes cooperate during primi

252 the known ASF1-H3-H4 interface, raising the question of how these two proteins are found in complex

253 related biochemical activities, raising the question of how these two proteins can perform separate

254 <3% of total flight muscle mass, raising the question of how they can modulate the vastly greater out

255 uation, even approximately, which raises the question of how they can occur in the real world.

256 mbryos of different fly species, raising the question of how they evolve this function.

257 d soon disappear from the lungs, raising the question of how they induce such durable immunosuppressi

258 around important regulatory genes raises the question of how they relate to 3D conformation of these

259 to the broader neuronal population, raising questions of how they might contribute to hippocampal fu

260 organize into tissues, naturally raising the question of how this collective organization arises.

261 rdless of the original source of energy, the question of how this energy is transferred to the ICM re

262 such major hurricane, Maria, and answers the question of how this event compares to the historical re

263 Of theoretical importance is the question of how this metric, and the resulting map, is c

264 evidence for anthropogenic fire, raising the question of how this period of global cooling may have a

265 ant role in sensory coding, yet to date, the question of how this regularity alters the coding of tra

266 We also address the question of how this structural information may link Tau

267 eadily dissociate from PKA, thus begging the question of how tightly bound cAMP is released from PKA

268 ch attention has been devoted to the fraught question of how to allocate intensive care unit beds and

269 This includes the question of how to best capture all plant diversity, as

270 The question of how to build and evolve efficient screening

271 Machine learning addresses the question of how to build computers that improve automati

272 ber of potential experiments, which begs the question of how to choose the best possible experiment.

273 Here, we revisit the question of how to codify their diversity based upon the

274 IGNIFICANCE STATEMENT We address the central question of how to comprehensively define molecular mech

275 mesenchymal transition (EMT), we address the question of how to define and recognize EMT processes an

276 This has raised the question of how to determine and to quantify the sources

277 This raises the question of how to engineer such desirable properties in

278 problem of long-term credit assignment: the question of how to evaluate the utility of actions withi

279 w no convincing answer has been given to the question of how to extend the scope of QKD beyond niche

280 nt of small-scale quantum devices raises the question of how to fairly assess and detect quantum spee

281 This raises the question of how to incorporate the microbiota into defin

282 ell optimized for clustering cell types, the question of how to integrate multiple scATAC-seq data se

283 This naturally raises the question of how to maximize health and longevity in an a

284 ble platforms for addressing the fundamental question of how to reverse the adverse biochemical outpu

285 to the treatment of multiple sclerosis, the question of how to select and sequence different treatme

286 e search for a straightforward answer to the question of how to support teachers.

287 's rapidly growing population has raised the question of how to systematically utilize large genebank

288 to the Arctic confront policymakers with the question of how to weigh a century-scale warming with la

289 fSTREAM addresses core questions of how to relate fluorescence intensity to tum

290 esis machineries remain obscure, raising the question of how tumour cells efficiently coordinate and

291 ight the potency of this model and raise the question of how useful it is for interpreting the system

292 n, few studies have attempted to address the question of how variation in learning and memory impacts

293 It also focuses attention on the question of how viruses have evolved to resist inhibitio

294 ites of every compass neuron(6), raising the question of how visual cues are integrated into the comp

295 e been identified from IEM patients, but the question of how warmth triggers episodes of pain in IEM

296 site is 15 A from the membrane, raising the question of how water-soluble and membrane-embedded subs

297 from cognitive neuroscience that bear on the question of how we get from perception of sound patterns

298 the issue of how we perceive a beat, is the question of how we learn to generate and hold a beat.

299 The question of how we selectively create temporal stability

300 d for many DNA-binding proteins, raising the question of how widespread or specific to certain enzyme