ライフサイエンスコーパス: quiescent

1 hat this is because the majority of DTCs are quiescent.

2 ituated to hyperglycaemia were energetically quiescent.

3 Quiescent Abeta42 fibrils adopt a long and twisted morph

4 rial respiratory complex I-that is active in quiescent adult beta-cells and hyperactive in beta-cells

5 GLUT1 deletion from quiescent adult ECs leads to severe seizures, accompanie

6 New neurons arise from quiescent adult neural progenitors throughout life in sp

7 bryonic mesothelial origin of their discreet quiescent adult precursor.

8 n be whole-life traced back through specific quiescent adult precursors to differential origin in dev

9 of immune cellular activity in the seemingly quiescent allograft.

10 The genome is initially transcriptionally quiescent, allowing the zygote to be reprogrammed into a

11 five different support cell types, including quiescent and activated stem cells.

12 of the autofluorescence lifetime signals of quiescent and activated T cells can be used to classify

13 act proviruses was rapid and similar in both quiescent and activated T cells.

14 two types of Abeta42 fibrils prepared under quiescent and agitated conditions.

15 mammalian counterparts, which are generally quiescent and do not undergo neuronal differentiation du

16 igh proliferation, and mature pericytes were quiescent and elongated.

17 ophy progression in areas co-localizing with quiescent and exudative type 1 CNV.

18 lasticity during development before becoming quiescent and functionally mature.

19 he Sel1L/Hrd1 ERAD genes are enriched in the quiescent and inactive HSCs, and conditional knockout of

20 vation of a distinct subset of mRNAs both in quiescent and maturing oocytes, a function recapitulated

21 f the tumour which is proliferating, hypoxic/quiescent and necrotic/nutrient-deficient).

22 Although the liquid is initially quiescent and no external flow is imposed, persistent fl

23 s were identified, one tissue restricted and quiescent and one more blood accessible, that gradually

24 Adult neural stem cells are mostly quiescent and only rarely enter the cell cycle to self-r

25 Mature oocytes are transcriptionally quiescent and possess remarkably broad domains of H3K4me

26 ental arrest in which precursor cells remain quiescent and preserve developmental potential, anticipa

27 ntities in glioblastoma, and mark relatively quiescent and proliferative GSCs, respectively.

28 signaling pathway is essential for both the quiescent and proliferative states of neural stem cells.

29 oenvironmental "niche" to transition between quiescent and regenerative states.

30 in AML patients, the majority of HSPCs were quiescent and showed enrichment of functional HSCs.

31 of large tissues becomes very dense, almost quiescent, and ceases cell-cycle progression.

32 Dormant tumor cells are quiescent, and thus, do not respond to chemotherapies or

33 They are functionally quiescent at homeostasis but can be activated by IL-33 t

34 by in vitro infection and transformation of quiescent B cells into lymphoblastoid cell lines (LCLs).

35 ological recordings describe an electrically quiescent behavior for dispersed zG cells.

36 Here we describe a Caenorhabditis elegans quiescent behavior, post-response quiescence (PRQ), whic

37 e resident in tissues, must therefore remain quiescent between infections despite chronic stimulation

38 atopoietic stem cells (HSCs) that are mostly quiescent but occasionally divide and self-renew to main

39 required sustained NEUROG3 expression in the quiescent, but not in the senescent, state.

40 Prophages are largely quiescent, but they can alter host phenotype through fac

41 Our findings define a quiescent cancer stem cell population in glioblastoma th

42 r-beta) signaling to stimulate conversion of quiescent cardiac fibroblasts into Periostin (Postn)-pos

43 4-3 infection of metabolically activated and quiescent CD4 T cells (cultured with 2 ng/ml interleukin

44 ated increased infection of activated versus quiescent, CD4(+) versus CD8(+), and blood- versus lymph

45 tackle the difficult challenge of enticing a quiescent cell to enter the cell cycle, but also achieve

46 chinery was accompanied by the appearance of quiescent cell-specific repressors and rewiring of the i

47 asymmetric Notch signaling, yet RSCs remain quiescent (cell cycle-arrested) without damage.

48 in1 (200 nmol/L) increased the percentage of quiescent cells (G(0) phase) from 24% to 48% compared wi

49 Our work reveals that quiescent cells actively maintain centromere identity pr

50 In this review, we explore the diversity of quiescent cells and highlight the unifying characteristi

51 f the long bound fraction was up to 1 min in quiescent cells and significantly increased upon stimula

52 How the quiescent cells are established and maintained is poorly

53 Quiescent cells are remarkably diverse-they reside in di

54 In this work, we show that in quiescent cells DBC1 is proteolytically cleaved, produci

55 We propose that quiescent cells express DN-DBC1, which either replaces o

56 sor can distinguish cycling cells in G1 from quiescent cells in G0, revealing a possible commitment p

57 d gradually and continuously incorporated in quiescent cells including G0-arrested tissue culture cel

58 One of the hallmarks of quiescent cells is highly condensed chromatin.

59 Despite this diversity, all quiescent cells must be able to persist in a nondividing

60 rapid divergent response occurs because some quiescent cells produce new KRAS(G12C) in response to su

61 Interestingly, DN-DBC1 is cleared once quiescent cells re-enter to the cell cycle.

62 In contrast, nondividing quiescent cells remove old nuclear pores in an ESCRT-dep

63 of the bronchial epithelium from mitotically quiescent cells that have avoided tobacco mutagenesis.

64 We used gene-expression analysis in quiescent cells to analyze responses to subtle and stron

65 em cells (CSCs) are a small subpopulation of quiescent cells with the potential to differentiate into

66 ide analog incorporation that does not label quiescent cells, a property of most PCs.

67 n the order of 10-60 kilobases that, only in quiescent cells, are formed by condensin-mediated loops.

68 Furthermore, these events accumulated in quiescent cells, suggesting that the causative DSBs may

69 In contrast to quiescent cells, terminally differentiated cells fail to

70 In quiescent cells, where strong transcriptional repression

71 provide adjacent zones of dividing and more-quiescent cells, which forms a foundation for further ra

72 meostasis and regeneration require a pool of quiescent cells.

73 increased in proliferative cells compared to quiescent cells.

74 s of thin cellular processes in mechanically quiescent cells.

75 Quiescent CENP-A incorporation involves the canonical CE

76 es including the root meristem (ERF103), the quiescent center (ERF104) and the root vasculature (all)

77 The quiescent center (QC) of the Arabidopsis (Arabidopsis th

78 ically active population of cells called the quiescent center (QC).

79 ions and rare cell types, including putative quiescent center cells, were identified.

80 It revealed that quiescent centre cell divisions produce two identical ce

81 asymmetric division previously described for quiescent centre stem cells.

82 The bona fide quiescent CFs derived from human induced pluripotent ste

83 IL1 receptor-associated protein (IL1RAP) in quiescent CML stem cells may offer an opportunity for a

84 pithelium (RPE) atrophy with treatment-naive quiescent CNV (n=7), RPE atrophy with a history of exuda

85 In patients with quiescent Crohn's disease involving the small bowel, fae

86 med a single-blind trial of 52 patients with quiescent Crohn's disease or ulcerative colitis and pers

87 In the current study, we observed that quiescent CUB-domain-containing protein 1 (CDCP1)+ CSCs

88 slow growth, and even decrease viability of quiescent cultures.

89 Therefore, quiescent Cxcl12-creER(+) BMSCs transform into osteoblas

90 nalysis using Cxcl12-creER mice reveals that quiescent Cxcl12-creER(+) perisinusoidal BMSCs different

91 e course of Crohn's disease in patients with quiescent disease.

92 ing DPSCs undergoing anastomosis, but not in quiescent DPSCs.

93 h the majority of these cells are remarkably quiescent during adult lung homeostasis, a growing body

94 Cs) in sites such as bone marrow that remain quiescent during endocrine therapy and subsequently prol

95 zebrafish embryo is transcriptionally mostly quiescent during the first 10 cell cycles, until the mai

96 e newly formed epithelium remains relatively quiescent during the next hour as it is patterned by mat

97 time-dependent pH changes of a suspension of quiescent E. coli metabolizing d-glucose.

98 Could chemical synapses have a quiescent electrical component?

99 rinsically impaired in extravasation through quiescent endothelia, a phenomenon that could contribute

100 vascular endothelial cells, but is absent in quiescent endothelial cells of the adult CNS.

101 otes the normal balance of VEGF signaling in quiescent endothelial cells to maintain vessel caliber-a

102 ium, little is known of VE-PTP's role in the quiescent endothelial monolayer.

103 Interestingly, when ECs become quiescent, endothelial glycolysis is repressed, and GLUT

104 o define the role of ERK1/2 signaling in the quiescent endothelium, we induced endothelial Erk2 knock

105 le Cells (FCs) from their posterior face and quiescent Escort Cells (ECs) to their anterior.

106 otype, whereas donor-origin T cells appeared quiescent, expressing oxidative phosphorylation genes.

107 s that are submerged beneath a deep layer of quiescent fluid and they travel over long distances alon

108 Rods settling under gravity in a quiescent fluid can overcome the bottleneck associated w

109 ries through the cortical compartment, where quiescent follicles reside and the medullary compartment

110 irst by briefly moving, and then become more quiescent for a period lasting tens of seconds.

111 These dormant parasites can remain quiescent for months or years, then reactivate causing s

112 a, may assume a state of dormancy, remaining quiescent for years before resuming proliferation and ca

113 recruited patients older than 18 years with quiescent (for 3-24 months) Crohn's disease involving th

114 drial membrane potential (MMP) distinguishes quiescent from cycling-primed HSCs.

115 e epithelial cells are a small population of quiescent gastric progenitor cells.

116 Before zygotic genome activation (ZGA), the quiescent genome undergoes reprogramming to transition i

117 ting viral DNA genomes more efficiently than quiescent genomes, consistent with the open structure of

118 deletion or FAO inhibition induces bona fide quiescent ground-state ESCs with an intact core pluripot

119 Quiescent H2-K1(high) cells account for virtually all in

120 During liver injury, quiescent hepatic stellate cells (qHSCs) transdifferenti

121 hrough constraints on cell cycle re-entry of quiescent hepatocytes.

122 tion does not appear to affect the number of quiescent HF stem cells, it leads to reduced numbers of

123 ining HSCs, which are, in old mice, the most quiescent HSC subpopulation with the highest regenerativ

124 Quiescent HSCs are thought to rely on glycolysis for the

125 In contrast, quiescent HSCs, hepatocytes, Kupffer cells, sinusoidal e

126 ivity in livers of sham-operated rats and in quiescent HSCs.

127 cifically target the activated HSCs, but not quiescent HSCs.

128 -146a depleted a subpopulation of primitive, quiescent HSCs.

129 d degradation (ERAD) governs the function of quiescent HSCs.

130 We found that primed, but not quiescent, HSCs relied readily on glycolysis.

131 these sgRNAs to observe the first editing of quiescent HSV-1 DNA.

132 onstitutes the in-situactivation dynamics of quiescent human antigen-specific T-cells interacting wit

133 pendent chromatin compaction is conserved in quiescent human fibroblasts.

134 DMAP diet vs a control diet in patients with quiescent IBD, we found no significant difference after

135 ing markers of inflammation in patients with quiescent IBD.

136 ing persistent gut symptoms in patients with quiescent IBD.

137 However, making the granule cells overly quiescent in both epileptic and control mice again disru

138 Although the black hole is essentially quiescent in the broader context of active galactic nucl

139 overall regulation of VGSCs by HSV-1 during quiescent infection was proved by increased transcriptio

140 ion, and although it typically establishes a quiescent infection with little to no disease in most in

141 nd polyols (FODMAPs) reduces gut symptoms in quiescent inflammatory bowel disease (IBD).

142 ng is safe in physically unfit patients with quiescent Inflammatory Bowel Disease and can quickly ach

143 degree of interconvertible states including quiescent, inflammatory, and myofibroblastic phenotypes;

144 om) RdRp-RNA in situ structures-representing quiescent, initiation, early elongation, elongation and

145 uppel-like factor 4 (KLF4) activates certain quiescent intestinal stem cells (ISCs) marked by Bmi1-Cr

146 ium can be attributed to its ability to form quiescent intracellular reservoirs in bladder cells and

147 a more dendritic morphology, indicative of a quiescent keratocyte phenotype.

148 -Lamin A/C-binding sites emerged in normally quiescent loci.

149 s reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatibl

150 ould lead to therapies that allow for a more quiescent lung that is less predisposed to symptoms and

151 , number of endpoints, the expression of the quiescent markers: Aldehyde Dehydrogenase 1 Family Membe

152 rrent bouts synchronous with the hair cycle, quiescent melanocyte stem cells (McSCs) become activated

153 This causes quiescent melanocyte stem cells to proliferate rapidly,

154 we report pSmad3 expression is restricted to quiescent MG and suppressed in injury-responsive MG.

155 truction from glial cells, can stabilize the quiescent microvasculature or enrich local neuronal micr

156 eage is also required for the maintenance of quiescent MSCs, suggesting that BMP signaling not only i

157 Muscle satellite cells (MuSCs) are the quiescent muscle stem cells required for adult skeletal

158 rmacological activation of K(IR) channels in quiescent muscle via infusion of KCl amplified peak ACh-

159 rmacological activation of K(IR) channels in quiescent muscle via intra-arterial infusion of KCl inde

160 a diverse range of CD4(+) T cells, including quiescent naive and central memory cells that are typica

161 differentiation, a complex process in which quiescent naive CD4 T cells undergo transcriptional chan

162 ice, where loss of VISTA disrupted the major quiescent naive T cell subset and enhanced self-reactivi

163 show that in the hippocampus of adult mice, quiescent neural precursor cells (NPCs) maintain the hig

164 Quiescent neural stem cells (NSCs) in the adult brain ar

165 Quiescent neural stem cells present a low rate of metabo

166 membrane growth and make first contact with quiescent neuroblasts.

167 t to IVIG, IgA did not promote cell death of quiescent neutrophils.

168 mes in the regulation of proteostasis during quiescent NSC activation.

169 This will require an understanding of quiescent NSC heterogeneities and regulation during norm

170 or of DNA binding protein Id4 is enriched in quiescent NSCs and that elimination of Id4 results in ab

171 We further show that quiescent NSCs are the main source of their local ECM, i

172 We found that G(2)-quiescent NSCs become activated prior to G(0) NSCs.

173 It is hoped that quiescent NSCs could be activated therapeutically to con

174 It is becoming apparent that quiescent NSCs exhibit heterogeneity in their propensity

175 ious models, a first step towards harnessing quiescent NSCs for therapeutic purposes.

176 suspected, and whose disease apparently was quiescent on clinical examination were included.

177 lue in those with occult lesions that appear quiescent on SD OCT, as this type of lesion may show lea

178 e the timing of maternal mRNA translation in quiescent oocytes as well as in oocytes progressing thro

179 c re-entry, whereas transcripts repressed in quiescent oocytes become activated.

180 r RNAs whose translation is highly active in quiescent oocytes invariably become repressed during mei

181 anscription promotes CENP-A incorporation in quiescent oocytes.

182 accuracy, and according to activation state (quiescent or activated) and subtype (CD3(+)CD8(+) or CD3

183 otypic diversity, including the formation of quiescent or dormant forms that contribute to the establ

184 ll cycle determined whether they either went quiescent or entered another cell cycle but stalled in S

185 ere characterized by a metabolism typical of quiescent or memory T cells, and did not participate in

186 mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1

187 (SGBs) and germline stem cells (GSCs) to be quiescent or progress developmentally is regulated diffe

188 A total of 122 patients with quiescent or stable, mildly active IBD were randomly ass

189 ed the activation and secretory phenotype of quiescent pancreatic stellate cells and established an i

190 ia-infected patients and artemisinin-induced quiescent parasites.

191 The IJ quiescent period increased at <=20 degrees C but did not

192 The quiescent period was overcome by dispersal pheromone ext

193 capsae IJs exhibited a temperature-dependent quiescent period.

194 Quiescent-period gating retaining approximately 50% of c

195 e phase) and exponential-like (delta-bursts, quiescent phase) duration distributions, features typica

196 e phase) and exponential-like (delta-bursts, quiescent phase) duration distributions, typical feature

197 confirmed that iPSC-derived CFs preserved a quiescent phenotype and highly resembled primary CFs at

198 1 (Setanaxib)] of NOX4 "normalized" CAF to a quiescent phenotype and promoted intratumoral CD8(+) T-c

199 ntrols vascular maturation and maintains the quiescent phenotype of resting vasculature.

200 Stressed cells also presented a quiescent phenotype, correlating with NF-kappaB nuclear

201 uctively infected SCM, we suggest that their quiescent phenotype, increased susceptibility to HIV-1 i

202 a gradual decline from a cytotoxic to a more quiescent phenotype.

203 Similar events should be very rare in quiescent planetary systems of the age of Fomalhaut, sug

204 e maturation of proliferating plasmablast to quiescent plasma cell under survival conditions includin

205 data for thrombin generation in vitro in 1) quiescent plasma exposed to patches of tissue factor and

206 ere is not a genuine patch size threshold in quiescent plasma-clotting always occurs given enough tim

207 es Landau damping of these fluctuations in a quiescent plasma-one of the most fundamental physical ph

208 scarring during liver injury, with putative quiescent precursor mesodermal derivation.

209 was compared between mock- and VZV-infected quiescent primary human spinal astrocytes (qHA-sps).

210 l replication was evaluated in activated and quiescent primary T lymphocytes, and the results demonst

211 ex and differentiate into granulosa cells of quiescent primordial follicles.

212 parasite removal was associated with a more quiescent profile.

213 adhesion, while parasite removal with a more quiescent profile.

214 lly making decisions about whether to remain quiescent, proliferate, or differentiate into mature cel

215 204 (miR-204), to control the maintenance of quiescent (q)NSCs.

216 development and then transition into Hopx(+) quiescent radial glial-like neural progenitors during an

217 lear, and a large body of work suggests that quiescent "reserve" ISCs contribute to regeneration.

218 single-nucleosome resolution genome-wide in quiescent Saccharomyces cerevisiae cells.

219 uld not only regenerate fibers but provide a quiescent satellite cell pool ensuring long-term mainten

220 ll identity, and premature exhaustion of the quiescent satellite cell pool.

221 ation, proliferation, and differentiation of quiescent satellite cells, the expression of Phospho1 gr

222 scription factor Slug is highly expressed in quiescent SCs of mice and functions as a direct transcri

223 Wnt4 activates Rho in quiescent SCs to maintain mechanical strain, restrict mo

224 b1-expressing centroacinar cells are largely quiescent, self-renew, and, as shown by genetic lineage

225 It inhibited germination in quiescent spores of B. cinerea In germlings, it breached

226 The life cycle of many organisms includes a quiescent stage, such as bacterial or fungal spores, ins

227 an active secretory state to a nonsecretory quiescent state (dedifferentiation) and back.

228 tive state in the fetus to a more mature but quiescent state after birth.

229 y which mature endothelial cells exit from a quiescent state and compromise barrier function.

230 aling pathway could lead cardiomyocytes to a quiescent state and enhance cardiomyocyte maturation.

231 cardiomyocytes with Torin1 shifts cells to a quiescent state and enhances cardiomyocyte maturity.

232 uration, desiccation tolerance, entry into a quiescent state and longevity.

233 at most of the endothelial cells reside in a quiescent state and progress to the haematopoietic fate

234 h is essential for establishing an effective quiescent state and the coordinated resumption of growth

235 Trpv6-mediated Ca(2+) influx maintained the quiescent state by suppressing insulin-like growth facto

236 on, whereas IL-21 maintained a metabolically quiescent state dependent on oxidative phosphorylation.

237 proliferatively-active state to mitotically-quiescent state dramatically decreased neurogenesis in t

238 esults suggest that M. tuberculosis enters a quiescent state during latency, decreasing the risk for

239 s are permissive for HSV-1 infection; (ii) a quiescent state exhibiting key landmarks of HSV-1 latenc

240 opulations maintained the viral genomes in a quiescent state for at least 5 wk postinfection.

241 from a proliferative state to a mitotically-quiescent state in the demyelinated hippocampus.

242 The genuine-quiescent state is unexpectedly preserved into later lif

243 A quiescent state of infection mimicking latency can be ac

244 T cells maintain a quiescent state prior to activation.

245 Naive T cells are actively maintained in a quiescent state that promotes their survival and persist

246 of pregnancy, the uterus transitions from a quiescent state to a highly contractile state.

247 ing pregnancy, the uterus transitions from a quiescent state to a more excitable contractile state.

248 rneal keratocytes from a native mechanically quiescent state to an activated myofibroblastic state.

249 ment, some cancer cells are sequestered in a quiescent state with low KRAS activity, whereas others b

250 s importance, the mechanisms underlying the "quiescent state" remain elusive.

251 excretion relative to the same cells in the quiescent state, a phenomenon known as the Warburg effec

252 riod of proliferation before entering a more quiescent state, and that a complex interaction between

253 large-scale collective motion emerges in the quiescent state, and the flow becomes nonlinear.

254 uscle, muscle stem cells (MuSCs) reside in a quiescent state, but little is known about the mechanism

255 side predominantly in a mitotically dormant, quiescent state, but they can proliferate in response to

256 escence, and their long-term survival in the quiescent state, can be rescued by exogenously added tre

257 y, liberation of meristematic cells from the quiescent state, root and shoot growth and architecture,

258 This brief quiescent state, which we refer to as microfluidic-induc

259 omotes exit of the Bmi1-Cre(ER) cells from a quiescent state.

260 own-regulated IGF signaling and promoted the quiescent state.

261 ess growth factor signaling and maintain the quiescent state.

262 ion hybrids survived for extended times in a quiescent state.

263 aining hair follicle stem cells (HFSCs) in a quiescent state.

264 ut not its channel dead mutant, restored the quiescent state.

265 s preserve a far developed plant embryo in a quiescent state.

266 the unifying characteristics that define the quiescent state.

267 l cues by exiting pluripotency or entering a quiescent state.

268 bservation of many samples in an "absolutely quiescent" state, while also removing some troublesome a

269 actor Ascl1 regardless of their activated or quiescent states.

270 Improved understanding of quiescent stem cell dynamics is leading to novel approac

271 c regression model built with eight of these quiescent stem cell marker genes (GSE70696_QNPbyTAP) was

272 ules showed significant enrichment of rodent quiescent stem cell marker genes (GSE70696_QNPbyTAP).

273 tory modules are characterized by diagnostic quiescent stem cell marker genes, which may potentially

274 tissue renewal posits that small numbers of quiescent stem cells (SCs) give rise to proliferating tr

275 onally, it facilitated the identification of quiescent stem cells and revealed genes that contribute

276 phila brain, challenging the notion that all quiescent stem cells are G(0) arrested.

277 Quiescent stem cells exhibit a low level of protein synt

278 ant progress has been made in characterizing quiescent stem cells thanks to the introduction of new g

279 yperplasia and fate specification defects in quiescent stem cells.

280 r of proliferating progenitor cells and lost quiescent stem cells.

281 homeostatic skeletal muscle, we identify two quiescent stem-cell states distinguished by relative CD3

282 Although OLIG2(+) progenitors become quiescent stem-like cells in full-blown tumors, they are

283 m 650 to 1250 CE and a shift to a relatively quiescent storm climate in the GOM spanning the past six

284 ted robust proliferation of mature, normally quiescent striolar SCs.

285 dherin, and stimulates proliferation in long-quiescent supporting cells within a balance epithelium f

286 Yet, normally quiescent suspensor cells can develop a second embryo wh

287 Metabolically quiescent T cells circulate throughout the body in searc

288 and diminished proliferation, a hallmark of quiescent T1 prospermatogonia.

289 tic compartment, capable of switching from a quiescent to an active proliferative state during angiog

290 cells increase glucose uptake and shift from quiescent to anabolic metabolism.

291 Hematopoietic stem cells (HSCs) remain quiescent to preserve long-term integrity.

292 tivated Treg (aTreg) cells at the expense of quiescent Treg cells, and also resulted in impaired Treg

293 Strikingly, CA-derived relatively quiescent tumor precursors with ancestral diploid/2N gen

294 l adenocarcinoma (PDAC) represents an immune quiescent tumor that is resistant to immune checkpoint i

295 .19-0.24) in the presence of treatment-naive quiescent type 1 CNV and by a factor of 0.46 (95% CI, 0.

296 3D co-cultures maintained cancer cells in a quiescent, viable state as measured by both single-cell

297 imes precedes eruptions but mostly occurs at quiescent volcanoes.

298 genic iron (oxyhydr)oxides (BIOs), common to quiescent waterways and soil redox transitions, possess

299 a less apparent way by remaining relatively quiescent while being challenged by chemical feedback.

300 directly generating a memory-like subset of quiescent yet antigen-experienced CD8(+) T cells that ar