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1 henyl as a preferred substitution on the N-3 quinazolinone.
2 lasses, which are the amino alcohols and the quinazolinones.
3 ted amines/amides, C-methylated products and quinazolinones.
4 developed for the synthesis of 2-substituted quinazolinones.
5 for the easy generation of new and bioactive quinazolinones.
6  synthesis of keto-methylated dihydropyrrolo-quinazolinones.
7 olidines, phenanthridines, quinoxalines, and quinazolinones.
8 4]diazepine-2,5-dione substrates to generate quinazolinones.
9  diversely fused N1-C2 or C2-N3 indolopyrido-quinazolinones.
10 e 2-(2'-hydroxyphenyl)-6-[(125)I]iodo-4-(3H)-quinazolinone ((125)IQ(2-OH)).
11 4'-dihydroxyphenyl)-6-[127I/125I]iodo-4-(3H)-quinazolinone (127IQ2-OH,4-OH (2)/125IQ2-OH,4-OH (7)) wa
12 pine (2b) were modified to produce tricyclic quinazolinone 15-18 or benzothiadiazine 26-27 derivative
13      5,7-Dihydroxy-3-(4-hydroxyphenyl)-4(3H)-quinazolinone (1aa) acts as an agonist on both ER subtyp
14 d solvent-free approach for the synthesis of quinazolinones (23 derivatives) and benzothiazoles (23 d
15 the potent antitubercular 2-thio-substituted quinazolinone 26.
16 se efforts led directly to identification of quinazolinone 28 that displays high selectivity for PI4K
17 oted isomerization of iminobenzoxazine 33 to quinazolinone 34, an N-acyliminium ion cyclization that
18 olo[1,2-a]benzoxazinones 3 and pyrrolo[1,2-a]quinazolinones 4, respectively, in good overall yields.
19                                              Quinazolinones 8 and pyrido[3,4-d]pyrimidin-4-ones 9 as
20              The improved performance of the quinazolinones against the mutant enzyme is attributed t
21 a-/chiral sulfamidates, followed by a tandem quinazolinone-amidine rearrangement termed SQuAReS.
22 rug development strategies, we herein report quinazolinone and quinazolinedione based modulators for
23 iciency, leading to high yields of 2-benzoyl quinazolinones and 2-aryl quinazolinones under optimized
24 ynthetic approach for synthesizing 2-benzoyl quinazolinones and 2-aryl quinazolinones via molecular i
25 s encountered in nonsteroidal inhibitors are quinazolinones and benzothiazinones/benzothiazepinones.
26 d light on the underexplored pharmacology of quinazolinones and further elucidate the molecular mecha
27 MR spectroscopies show that deprotonation of quinazolinones and phenylacetylene in THF/pentane soluti
28 egy for generating heterocyclic diversity of quinazolinones and quinolines on indolizines.
29 the syntheses of 79 derivatives of the 4(3H)-quinazolinones and their structure-activity relationship
30                                              Quinazolinones are common substructures in molecules of
31 oad substrate scope is demonstrated for both quinazolinone as well as diaryliodonium triflates.
32 iscover four novel series of 53 compounds of quinazolinone based on the concept of molecular hybridiz
33        Quin-C1 is a prototype of substituted quinazolinones based on which further structural modific
34  a program to develop practical syntheses of quinazolinone-based nonnucleoside reverse transcriptase
35 ptimization of a potent, selective series of quinazolinone-based TRPA1 antagonists.
36                                     The lead quinazolinone, BDGR-49, potently reduced cellular VEEV a
37 precursor for the synthesis of N-substituted quinazolinones by incorporation of a palladium-catalyzed
38 mble 2-amino-3-substituted and 3-substituted quinazolinones by the domino/tandem cross-coupling react
39  a novel synthesis of different indolopyrido-quinazolinones by the reaction of easily accessible 2-in
40                       We therefore evaluated quinazolinone calcilytics (ATF936 and AXT914) as an alte
41                  These studies indicate that quinazolinone calcilytics may have potential for treatin
42 arylsulfonyl-piperazine and spiro-piperidine-quinazolinone classes were identified with up to approxi
43 ic screening found that 2,3,6-trisubstituted quinazolinone compounds are novel inhibitors of ZIKV rep
44                        The high potential of quinazolinone containing natural products and their deri
45 he introduction of polar substituents on the quinazolinone core allowed reduction of bovine serum alb
46 nhibitors through SAR exploration around the quinazolinone core and the 4'-position of the phenyl res
47 iscovery that capsid inhibitors comprising a quinazolinone core tolerate a wide range of structural m
48 ry of a novel antibacterial (2) with a 4(3H)-quinazolinone core.
49 the first regioselective C-5 alkenylation of quinazolinone-coumarin conjugates via ruthenium(II) cata
50 nally designed and radiolabeled with (18)F a quinazolinone derivative ([(18)F]LCE470) with subnanomol
51                       The most active thioxo-quinazolinone derivative 16 showed extraordinarily high
52 gous to the earlier studies of the series of quinazolinone derivatives 3, we also found 3-isopropoxyp
53 eration of carbon-heteroatom bond leading to quinazolinone derivatives and aza-Michael adducts under
54 action-binding between a series of iodinated quinazolinone derivatives and human placental alkaline p
55 nsidering the broad therapeutic relevance of quinazolinone derivatives as anticancer, antimicrobial,
56 obenzimidazoles as well as fused tetracyclic quinazolinone derivatives in one-pot.
57                        We studied a class of quinazolinone derivatives of the lead structure FR20 for
58  In our laboratories, piperidine-substituted quinazolinone derivatives were identified as a new class
59 one scaffold were tolerated to provide novel quinazolinone derivatives.
60                             The Pd-catalyzed quinazolinone-directed regioselective monoarylation of a
61 The catalyst is also capable of synthesizing quinazolinone directly from 2-aminobenzamide and alcohol
62 enyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones DPC 082 and DPC 083 and the 4-alkynyl-3,
63 ynyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones DPC 961 and DPC 963 were found to exhibit
64                     While most of the tested quinazolinones exhibited no cytotoxicity against MRC-5,
65 nnulation strategy with 3-(2-(ethynyl)phenyl)quinazolinones for the sustainable synthesis of new clas
66 tion coupling ring-opening reaction of inert quinazolinone frameworks.
67                        A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated
68 -economical approach for the construction of quinazolinones from 2-nitrobenzaldehydes has been unveil
69 imple metal-free method for the synthesis of quinazolinones from commercially available 2-nitrobenzyl
70        A novel copper-catalyzed synthesis of quinazolinones from easily available 2-arylindoles and a
71          An unprecedented synthesis of fused quinazolinones from N-pyridylindoles under oxidative con
72 rnishes a series of substituted indolo[1,2-a]quinazolinones from the suitably fabricated indoles via
73 ficant molecules, such as benzoxazinones and quinazolinones, from simple anilides without installing
74 al products containing benzodiazepinone- and quinazolinone-fused ring systems can be assembled by non
75                                     This new quinazolinone has potent activity against methicillin-re
76 the 1,2-addition of PhCCLi to an O-protected quinazolinone implicates reaction via trisolvated PhCCLi
77 ations leading to distinctive functionalized quinazolinones in good yields.
78 s has been developed, which provided various quinazolinones in up to 99% yields for 43 examples.
79 tructure of the enzyme bound to a 2-mercapto-quinazolinone inhibitor shows that the compound interact
80 ium 2-(2'-phosphoryloxyphenyl)-6-iodo-4-(3H)-quinazolinone (IQ(2-P)) was docked in silico into the X-
81 -(2',4'-diphosphoryloxyphenyl)-6-iodo-4-(3H)-quinazolinone (IQ2-P,4-P), having the most favorable cal
82       A synthesis of dihydropyrazino-[2,1-b]-quinazolinones is described using a 2-alkylaminoquinazol
83 philes to chiral auxiliary substituted 2(3H)-quinazolinones is described.
84 d-phase synthesis of 2-arylamino-substituted quinazolinones is described.
85 Cu-catalyzed intramolecular C-N arylation of quinazolinone, leading to a sclerotigenin analogue that
86 llowed by chemical synthesis of a library of quinazolinones, led to the discovery of (E)-3-(3-carboxy
87                              Methaqualone, a quinazolinone marketed commercially as Quaalude, is a ce
88               The compounds bearing a thioxo-quinazolinone moiety can therefore be assigned as pure E
89                             All of the novel quinazolinones of biological interest were synthesized b
90 ement to synthesize exo-olefinic-substituted quinazolinone or oxazoloquinazolinone is reported.
91 ts, including benzophenones, acridinones and quinazolinones or quinazolines was identified and measur
92                We established an antiamoebic quinazolinone pharmacophore, culminating in (+/-)-trans-
93 ve-membered pyrrole ring of indole, yielding quinazolinone pharmacophores-scaffolds of significant me
94 structure-guided optimization of a series of quinazolinone-pyrrolodihydropyrrolone analogs leading to
95                Herein, we report a series of quinazolinone-pyrrolopyrrolones as potent and selective
96 on of methaqualone (2-methyl-3-o-tolyl-4(3H)-quinazolinone, Quaalude), an infamous sedative-hypnotic
97 ompound library and identified a substituted quinazolinone (Quin-C1, 4-butoxy-N-[2-(4-methoxy-phenyl)
98 piperidinyl)ethyl]-2,3-dihydro-2-thioxo-4(1H)quinazolinone (R59949), which blocks HIF-1alpha protein
99 olefination at the C5-H site of 3-aryl-4(3H)-quinazolinone relies on weak coordination of O(carbonyl)
100                                              Quinazolinones resulting from a Mannich-coupled domino r
101                                          The quinazolinone ring has been exploited as a directing gro
102 harmacophores, an arylurea moiety of 1 and a quinazolinone ring of 3, from two known series.
103 ny biologically significant molecules is the quinazolinone ring system.
104                                              Quinazolinone rotational barriers about the chiral anili
105 rts leading to the identification of a novel quinazolinone scaffold are described, along with optimiz
106             Various functional groups on the quinazolinone scaffold were tolerated to provide novel q
107 ree dissimilar C-H bonds of the 3-aryl-4(3H)-quinazolinone scaffold with cyclic structurally nonflexi
108 ivator binding site (benzimidazole or thioxo-quinazolinone scaffolds).
109 n optimization effort was initiated around a quinazolinone screening hit 1 with promising cellular an
110    The pharmacophoric model, supported by 88 quinazolinones, several of which exhibit subnanomolar po
111  optimally distanced nucleophilic amine to a quinazolinone such that subsequent domino rearrangements
112                                          The quinazolinone template offers an exciting potential for
113 ges to the ethylene linker that connects the quinazolinone to the amide were also investigated but pr
114 ynergy is rationalized by the ability of the quinazolinones to bind to the allosteric site of penicil
115                                   Binding of quinazolinones to this site results in widening of the e
116 catalytic generation of either quinolones or quinazolinones, two alkaloid frameworks of exceptional b
117 ields of 2-benzoyl quinazolinones and 2-aryl quinazolinones under optimized conditions.
118                     A small family of phenyl quinazolinone ureas is reported as potent modulators of
119 atroposelective halogenation of 3-aryl-4(3H)-quinazolinones via kinetic or dynamic kinetic resolution
120 hesizing 2-benzoyl quinazolinones and 2-aryl quinazolinones via molecular iodine-mediated annulative
121 idation reaction for the facile synthesis of quinazolinone was developed.
122  synthesis of diverse substituted polycyclic quinazolinones was achieved by two orthogonal Ugi four-c
123 ition of lithium phenylacetylide (PhCCLi) to quinazolinones was investigated using a combination of s
124 ynyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones were found to be potent non-nucleoside re
125                                       2-Aryl-quinazolinones were identified and optimized into potent
126  the reaction of easily accessible 2-indolyl quinazolinone with propargylic alcohols has been develop
127 ocol on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH(4))(2)S(2)O(8) as an additive.
128 ysis (1 mol %) by a chiral cobalt porphyrin, quinazolinones with a tethered diazo alkane precursor un
129 ically relevant 3-arylquinazolin-4(3H)-ones (quinazolinones) with high levels of enantioinduction ove

 
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