ライフサイエンスコーパス: quinine

1 hloroquine, three hydroxychloroquine, and 45 quinine).

2 ne-free alcohol or saccharin with or without quinine.

3 is residual was abolished by the addition of quinine.

4 e predicted sucrose, while another predicted quinine.

5 impact preference for sucrose, saccharin, or quinine.

6 ncomplicated falciparum malaria treated with quinine.

7 o be involved in T2R4 binding to its agonist quinine.

8 serotonin production during incubation with quinine.

9 are the same orthosteric site as the agonist quinine.

10 ted ketones catalyzed by 9-amino(9-deoxy)epi quinine.

11 emical control at the chiral amine carbon of quinine.

12 rine (21b), completing a formal synthesis of quinine.

13 o a perithreshold concentration (0.01 mM) of quinine.

14 sumption of ethanol with the added bitterant quinine.

15 e addition of a chiral thiourea derived from quinine.

16 to react with other structural analogues of quinine.

17 d severe thrombocytopenia after ingestion of quinine.

18 reveal their important role in resistance to quinine.

19 complexes with a chiral cation derived from quinine.

20 esponses to the cues paired with sucrose and quinine.

21 or HCl prepulses attenuated the response to quinine.

22 as 2,2'-bipyridine, 1,10-phenanthroline, and quinine.

23 h intravenous artesunate proving superior to quinine.

24 with an artemisinin derivative compared with quinine.

25 se thrombocytopenia in patients sensitive to quinine.

26 a samples after drinking of tonic containing quinine.

27 d (0.03 m), monosodium glutamate (0.2 m), or quinine (0.001 m).

28 atterns of electrical stimulation or natural quinine (0.1 mM) as a conditioned stimulus, rats specifi

29 which have structures similar to that of (-)-quinine 1.

30 ific potassium channel antagonists including quinine (100 microm) and high concentrations of extracel

31 specific genetic factors for PROP (72%) and quinine (15%).

32 he neuronal-specific gap junction uncouplers quinine (250 microM) and mefloquine (500 nM) both disrup

33 ted by sucrose (39 of 52, 75%) or excited by quinine (30 of 40, 75%) infusions.

34 104 patient reports with definite evidence (quinine, 34; cyclosporine, 15; tacrolimus, 12).

35 d a developmentally regulated sensitivity to quinine, a drug that blocks Cx50 gap junctions, but not

36 te pairing with an aversive stimulus such as quinine, a paradigm considered to model compulsive aspec

37 An aversive stimulus, quinine, activated noradrenergic signaling but inhibited

38 L-lysine (BCML) as competitive inhibitors of quinine-activated T2R4 with an IC50 of 3.2 +/- 0.3 muM a

39 acology, we examined the effect of intraoral quinine administration on nucleus accumbens dopamine sig

40 closerine also selectively reduced intake of quinine-adulterated alcohol, and D-cycloserine inhibited

41 oline antimalarial drugs (e.g., chloroquine, quinine, amodiaquine) function by preventing hemozoin cr

42 our tastants (0.1 M NaCl, 0.01 M HCl, 0.01 M quinine and 0.5 M sucrose) in separate trials.

43 e facile synthesis of a copolymer containing quinine and 2-hydroxyethyl acrylate that effectively com

44 Quinine and ajmalicine formed charge-stabilized hydrogen

45 the clinical drugs lumefantrine, mefloquine, quinine and amodiaquine.

46 ole in malaria chemotherapy progressing from quinine and artemisinin to ozonide-based compounds.

47 No difference was evident between quinine and artesunate either in mortality or in hospita

48 ation responsive to the bitter taste stimuli quinine and cycloheximide, and aversive concentrations o

49 he involvement of alpha-gustducin in bitter (quinine and denatonium) and sweet (sucrose and SC45647)

50 ral avoidance of cycloheximide and PROP than quinine and denatonium, which also stimulate the CT, alb

51 ciated with the CS- also affects learning as quinine and distilled water enhanced the proportion of l

52 mical inhibition of mechanotransduction with quinine and EGTA protected against cisplatin-induced hai

53 therapy were treated with standard doses of quinine and followed for 28 days.

54 2D mutation in contributing to resistance to quinine and its diastereomer quinidine.

55 Immune thrombocytopenia induced by quinine and many other drugs is caused by antibodies tha

56 erm exposure (4 h), artemisinin derivatives, quinine and mefloquine impacted H2O2 levels in mitochond

57 urned to the few alternatives, which include quinine and mefloquine.

58 e anticancer agent vincristine, antimalarial quinine and neurotoxin strychnine, are synthesized in se

59 t pronounced interactions were found between quinine and NFC (1.4 x 10(4) M(-1)), whereas sucrose, as

60 n with 40 mm HEPES attenuated the effects of quinine and NH(4)Cl.

61 e pipette solution eliminated the effects of quinine and NH4Cl on the csNSC currents, but only partia

62 y derived IC50 concentrations of mefloquine, quinine and pyrimethamine.

63 pair of the nitrogen atom instead, and both quinine and quinidine exhibit additional bonding via the

64 Mefloquine, a close derivative of quinine and quinidine that exhibits antimalarial and ant

65 ased on dimerized versions of the substrates quinine and quinidine.

66 n as well as the stereospecific responses to quinine and quinidine.

67 evertheless, may have some ability to act on quinine and quinidine.

68 their reactions at various concentrations of quinine and quinine congeners.

69 ndicate that a hybrid paratope consisting of quinine and reconfigured antibody CDR plays a critical r

70 nferring resistance to the second-line drugs quinine and sensitivity to the new alternatives mefloqui

71 Quinine and sucrose preference was similar between genot

72 then liberates the (S)-ligand in the case of quinine and the (R)-ligand in the case of quinidine, bot

73 neralized the aversion to 2 bitter tastants: quinine and urea.

74 In view of the low efficacy of quinine and wide availability of highly effective artemi

75 ized mAb with low affinity in the absence of quinine and with fivefold greater affinity (K(D) approxi

76 ntly mechanistically distinct synergism with quinine and with piperaquine.

77 metabolism of isoprenoid-derived molecules (quinines and tocochromanols), lipids, and carotenoid cle

78 ake (that persists despite adulteration with quinine) and consumption of quinine-free alcohol.

79 .g. fungiform papillae number, bitterness of quinine) and emerging receptor genotypes.

80 creased susceptibility to LUM, halofantrine, quinine, and ART.

81 ed K(+) channel (charybdotoxin, iberiotoxin, quinine, and Ba(2+)) nor inhibitors of the mitochondrial

82 -Ras in the NAc of mice did not alter water, quinine, and saccharin intake.

83 bitter compounds tested, including caffeine, quinine, and strychnine.

84 bility to antimalarials such as chloroquine, quinine, and sulfadoxine-pyrimethamine.

85 dopamine signaling by the aversive stimulus, quinine, and tested its ability to cause cocaine seeking

86 ferent tastants (sucrose, salt, citric acid, quinine, and water) from a lick spout.

87 After controlling for differences between quinine- and artesunate-treated individuals using the in

88 lthough chloroquine, hydroxychloroquine, and quinine are used for a range of medical conditions, rece

89 Compared to quinine, artemisinin treatment in the first trimester wa

90 Using quinine as an endogenous reporter for pDNA intercalation

91 e asymmetric synthesis of sulfinamides using quinine as auxiliary.

92 y to feed on noxious foods (adulterated with quinine) as the duration of deprivation increases.

93 gh inhibition of 5-HT receptor activation by quinine, as we observed here.

94 rsive 'disgust' reactions elicited by bitter quinine at all NAc shell sites.

95 s suggest that PfCRT accepts chloroquine and quinine at distinct but antagonistically interacting sit

96 The remarkable isoform selectivity found on quinine-based selectors is explained by van't Hoff plots

97 y treated malaria, which can occur with oral quinine because of the known poor adherence to 7-d regim

98 n implicated as triggers for this condition, quinine being one of the most common.

99 atable (0.3 m sucrose) and aversive (0.001 m quinine) benchmarks, while recording the activity of neu

100 sidues Asn-173 and Thr-174 are essential for quinine binding.

101 smon resonance (SPR) analysis, we found that quinine binds with very high affinity (K(D) approximatel

102 infusion 150 min after breakfast, containing quinine (bitter), rebaudioside A (sweet), monosodium glu

103 aste sensitivity to salts (NaCl and KCl) and quinine ("bitter") but not to sucrose ("sweet").

104 o protons in the unbound, cocaine-bound, and quinine-bound forms of the cocaine-binding DNA aptamer.

105 imicked the electrophysiological response to quinine, but not when the temporal pattern was randomize

106 timuli indicated a common genetic factor for quinine, caffeine and SOA (22-28%), as well as separate

107 ains that mimic the response to the taste of quinine can produce a bitterlike sensation when delivere

108 ed the molecular recognition capability of a quinine carbamate ligand attached to silica as a powerfu

109 identical in requiring quinine or desmethoxy-quinine (cinchonidine) for reactivity and in failing to

110 ft should be made in health policy away from quinine + clindamycin therapy for malaria in pregnant wo

111 g combinations, atovaquone + azithromycin or quinine + clindamycin.

112 rnative ACT, which were given for 3 days, or quinine-clindamycin (QnC), which was given for 5-7 days,

113 This polymer system poly(quinine-co-HEA) packages pDNA and shows exceptional cell

114 In populations where, for example, quinine-color pairings were unreliable but quinine-odor

115 perience and reduced sensitivity to learning quinine-color.

116 netic analyses revealed that chloroquine and quinine compete for transport via PfCRT in a manner that

117 ryptophan hydroxylase (TPH2), we showed that quinine competitively inhibits TPH2 in the presence of t

118 value >/=0.997 in the range of 50-800 ng/ml quinine concentration.

119 ons at various concentrations of quinine and quinine congeners.

120 synaptic transmission; ethanol, sucrose, and quinine consumption; ethanol-induced loss of righting; a

121 Our work showcases the ability of this quinine copolymer reporter to not only facilitate effect

122 The auxiliary quinine could be recovered and recycled.

123 sucrose than during the tone associated with quinine delivered upon licking.

124 uli evoked strong responses in ASH including quinine, denatonium, detergents, heavy metals, both hype

125 e, we characterized the binding sites for 16 quinine-dependent antibodies thought on the basis of pre

126 Measurements of quinine-dependent binding of intact mAb and fragment ant

127 We addressed this question using quinine-dependent murine monoclonal antibodies (mAbs), w

128 Recently, quinine-dependent murine monoclonal antibodies were deve

129 ion toward another chiral molecule such as a quinine derivative.

130 A quinine-derived aminophosphine precatalyst and silver ox

131 .5:0.5 er) in the presence of CsOH.H2O and a quinine-derived ammonium salt.

132 cyclic allylic bromides using quinidine- or quinine-derived catalysts is described.

133 A zwitterionic quinine-derived entity generated by deprotonation of an

134 Quinine, dicyclohexylcarbodiimide, and Mg(2+), inhibitor

135 The study shows that quinine disrupts both serotonin biosynthesis and functio

136 nin (5-HT), here we test the hypothesis that quinine disrupts serotonin function.

137 A chemical screening approach revealed that quinine effectively prevented heme effects on the cytosk

138 We conducted prospective quinine efficacy studies in 2 villages, Kolle and Faladi

139 the rostral CeA were highly correlated with quinine-elicited gapes.

140 STDRHI mice consumed more saccharin and less quinine, exhibited greater ethanol-induced conditioned p

141 er artemisinin (1.5% [95% CI 0.6%-3.5%]) and quinine exposures (1.2% [95% CI 0.6%-2.4%]).

142 turally occurring antimalarial compounds are quinine, extracted from cinchona bark, and artemisinin (

143 st Herapath mixed iodine with the urine of a quinine-fed dog.

144 al intravenous therapy (38 artesunate and 49 quinine) followed by oral treatments.

145 ites and threefold in parasites treated with quinine for 30 min.

146 assays to evaluate small-molecule analogs of quinine for suppressive effects on aberrant hemichannel

147 known on the use of artesunate compared with quinine for the treatment of imported malaria cases in n

148 ol drinking, without altering consumption of quinine-free alcohol or saccharin with or without quinin

149 dulteration with quinine) and consumption of quinine-free alcohol.

150 stem was applied for selective extraction of quinine from human plasma.

151 The method is demonstrated on a mixture of quinine, geraniol, and camphene in deuteriated methanol,

152 te that the cinchona alkaloids quinidine and quinine give rise to products (some in as few as three s

153 Fifty patients died, 18 in the quinine group (n = 460) and 32 in the artesunate group (

154 ence cinchonine > quinidine > cinchonidine > quinine > 6-methoxyquinoline > lepidine > quinoline.

155 oms--for example alkaloids like morphine and quinine-have the potential to treat a broad range of hum

156 M NaCl, 0.5 M sucrose, 0.01 M HCl and 0.01 M quinine HCl).

157 nsisted of 0.1 m NaCl, 0.5 m sucrose, 0.01 m quinine HCl, and 0.01 m HCl.

158 The perceived taste intensities of quinine HCl, caffeine, sucrose octaacetate (SOA) and pro

159 ): 0.5 sucrose, 0.1 NaCl, 0.01 HCl, and 0.01 quinine-HCl.

160 The quinine homodimer Q2, which was tethered by reversible e

161 ht that is paired with an aversive stimulus (quinine-humidity).

162 1min) of dH2O, sucrose (1.0M and 0.1M), and quinine hydrochloride (3mM and 0.3mM) were video recorde

163 e-mediated acceptability of both ethanol and quinine hydrochloride (bitter), but not sucrose (sweet).

164 this study, we investigated the capacity for quinine hydrochloride (Q-HCL) to enhance the antimicrobi

165 um chloride (NaCl), 100 mM sucrose, and 1 mM quinine hydrochloride in mixtures were investigated in g

166 Guinea pigs did show weaker avoidance of quinine hydrochloride than did the mice, confirming pred

167 nt secondary metabolites (salicin, caffeine, quinine hydrochloride) and bitter protein hydrolysates (

168 quinine in 0.1 M perchloric acid rather than quinine in 0.05 M sulfuric acid as a standard solution f

169 dependence of fluorescence quantum yield for quinine in 0.05 M sulfuric acid.

170 ndicate that it should be recommended to use quinine in 0.1 M perchloric acid rather than quinine in

171 contrast, the fluorescence quantum yield of quinine in 0.1 M perchloric acid shows no temperature de

172 ison of parenteral artesunate and parenteral quinine in 9 African countries.

173 vation failed to alter TR to innately bitter quinine in either sex.

174 decreased susceptibility of P. falciparum to quinine in the field.

175 fusion of the intracellular alkalizing agent quinine increased the amplitude of the ASIC current by a

176 ated with appetitive sucrose versus aversive quinine, indicating that they behave like reward neurons

177 ound that the reduction of dopamine tone and quinine-induced cocaine seeking were eliminated by block

178 he behavior of antibodies from patients with quinine-induced immune thrombo-cytopenia in their reacti

179 During quinine-induced nausea and lipopolysaccharide (LPS)-indu

180 Moreover, when the quinine-induced pattern of neural activity in the second

181 r of antibodies found in human patients with quinine-induced thrombocytopenia in vitro and in vivo.

182 Quinine inhibited serotonin-induced proliferation of yea

183 alterations in water, saccharine/sucrose, or quinine intake were observed.

184 Quinine is by far the most popular fluorescence quantum

185 anism of Plasmodium falciparum resistance to quinine is not known.

186 s, a 7- to 10-day course of clindamycin plus quinine is often used to treat severe babesiosis.

187 PIIb beta propeller domain only when soluble quinine is present.

188 Therefore, quinine is used despite its poor effectiveness.

189 trial comparing parenteral artesunate versus quinine (ISRCTN50258054).

190 furocoumarins, metal coordination complexes, quinine-like compounds, naphthaleneimides and pyrenyl-pe

191 ctly to the attenuated aversion to ethanol's quinine-like taste quality.

192 Experiments 1 and 2 indicated that CPC has a quinine-like taste quality.

193 ions, but <10% with the nonartemisinin drugs quinine, mefloquine, and atovaquone-proguanil.

194 r alkalinization following bath perfusion of quinine mimicked the potentiation of the csNSC currents

195 two well-characterized aptamers for cocaine/quinine (MN4), chosen for its nanomolar range affinity,

196 e first trimester (n = 37/671) compared with quinine (n = 96/945; adjusted hazard ratio [aHR] = 0.73

197 m treatments with artemisinin (n=183) versus quinine (n=842; HR 0.78 [95% CI 0.45-1.34]; p=0.3645) or

198 isk of stillbirth (artemisinins, n = 10/654; quinine, n = 11/615; aHR = 0.29 [95% CI 0.08-1.02], p =

199 e find increased sensitivity to learning the quinine-odor experience and reduced sensitivity to learn

200 , quinine-color pairings were unreliable but quinine-odor pairings were reliable, we find increased s

201 iving important new insight to the action of quinine on mammalian cells.

202 For quinine, one or more bitter receptor or salivary proline

203 Quinine or alternative artemisinin-based combination tre

204 ith severe malaria treated parenterally with quinine or artesunate, and was recently shown to contrib

205 Here we show that artemisinins, but not quinine or chloroquine, inhibit the SERCA orthologue (Pf

206 ypes of antibody were identical in requiring quinine or desmethoxy-quinine (cinchonidine) for reactiv

207 ed to be a cinchona alkaloid derivative (TMS-quinine or Me-quinidine).

208 treated with artemisinin derivatives versus quinine or no antimalarial treatment.

209 of BH(3).SMe(2) and one equivalent of either quinine or quinidine.

210 derivative decreased mortality compared with quinine (OR 0.64 [95% CI 0.56-0.74]).

211 alternative ligands, prinomastat, quinidine, quinine, or ajmalicine, displaced both thioridazines.

212 amate/inosine-5'-monophosphate, citric acid, quinine, or artificial saliva (AS)] separated by five AS

213 ne displays a higher Kads than cinchonidine, quinine, or quinidine even though, according to previous

214 se was blocked by l-AP-4, meclofenamic acid, quinine, or strychnine but not by bicuculline.

215 votal one involves a resolution, through the quinine- or quinidine-promoted methanolysis of the cycli

216 GSTP1 (A313G), or with the C allele of NADPH quinine oxidoreductase (C609T), although interactions we

217 activity of ARE-driven genes HO1 and NAD(P)H:quinine oxidoreductase 1 (NQO1).

218 of its downstream gene targets such as NADPH quinine oxidoreductase 1 and superoxide dismutase in cer

219 NRP/B also enhanced Nrf2-mediated NAD(P)H:quinine oxidoreductase 1 promoter activity.

220 sferases (GSTM1, GSTT1, and GSTP1) and NADPH quinine oxidoreductase] and apoptosis, altering steroid

221 ved brief intraoral infusions of sucrose and quinine paired with cues in a classical conditioning par

222 The major antimalarial drug quinine perturbs uptake of the essential amino acid tryp

223 philicity/pH profile of a weakly basic drug (quinine; pK(a) = 7.95) was sigmoidal with respect to -dF

224 WHO recommends prompt diagnosis and quinine plus clindamycin for treatment of uncomplicated

225 aquone-proguanil is best, with mefloquine or quinine plus tetracycline or doxycycline as alternatives

226 a combination of atovaquone and proguanil or quinine plus tetracycline or doxycycline or clindamycin

227 drugs in patients with severe chloroquine or quinine poisoning.

228 nctional OCT1 variants, OCT1 inhibition with quinine prevented sorafenib-induced toxicity.

229 pi-vinyl catalysts based on cinchonidine and quinine promote a similarly high enantioselective reacti

230 9-Amino(9-deoxy)epi-quinine promoted the enantioselective desymmetrization,

231 implicated in responses to chloroquine (CQ), quinine (QN) and other drugs, and a putative transporter

232 ut does not measurably bind the related drug quinine (QN) at physiologically relevant concentrations.

233 levels in responses to chloroquine (CQ) and quinine (QN) in field isolates.

234 Quinine (QN) remains effective against Plasmodium falcip

235 re we show that mutant PfCRT also transports quinine, quinidine, and verapamil, indicating that the p

236 We found that quinine rapidly reduced dopamine signaling on two distin

237 plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indi

238 both disrupted 4-12 Hz oscillations but only quinine reduced the frequency of field population spikin

239 mbled the taste quality of either sucrose or quinine regardless of its intensity.

240 important because neither salt ingestion nor quinine rejection elicited analgesia.

241 Ser-33 with alanine reduced chloroquine and quinine resistance by ~50% compared with the parental P.

242 nd loss of verapamil reversibility of CQ and quinine resistance.

243 tially reconstitute the level of chloroquine/quinine resistance.

244 imulation of awake rats with citric acid and quinine resulted in significant increases in the numbers

245 complex with terreic acid revealed that the quinine ring is covalently attached to the thiol group o

246 he depigmenting abilities of chloroquine and quinine salicylate were assessed in a human skin equival

247 uppression of CPC, because both CPC-salt and quinine-salt mixtures had similar effects.

248 Xenopus laevis oocytes and determination of quinine-sensitive sorafenib uptake by high-performance l

249 ting that rats intraorally infused with 3 mM quinine showed a robust population of FLI in the waist a

250 Randomization of the quinine simulation patterns resulted in generalization p

251 conditioned aversion training using either "quinine simulation" patterns of electrical stimulation o

252 gnificantly reduced intake of all three CSs (quinine, sodium chloride, and orange odor).

253 ) was paired with sucrose and the other with quinine solution (CS-).

254 the quantum yield temperature dependence of quinine solutions in 0.05 M sulfuric acid and 0.1 M perc

255 On the other hand, the quinine-squaramide was more efficient in that a wide var

256 ganocatalysts, viz. a quinine-thiourea and a quinine-squaramide.

257 egeneration of the GL after 52 days restored quinine-stimulated FLI to control values.

258 strocaudal gradient characterized the normal quinine-stimulated Fos response, with the greatest numbe

259 Here, the distribution of quinine-stimulated Fos-immunoreactive neurons in two tas

260 The distribution of quinine-stimulated Fos-like immunoreactivity (FLI) in se

261 rvation by either nerve restored, numbers of quinine-stimulated labeled cells in the rostralmost CeA

262 Quinine-stimulated neurons were found throughout the gus

263 We previously demonstrated that quinine-stimulated oromotor rejection reflexes and neura

264 in the number of gapes elicited by intraoral quinine stimulation that recovered, but only subsequent

265 either stimulus but had a medial bias after quinine stimulation.

266 severely poisoned with either chloroquine or quinine (strong recommendation, very low quality of evid

267 The 3,5-bis(trifluoromethyl)phenyl- and quinine-substituted squaramide catalyst is shown to be t

268 Applying this strategy to quinine suggested complementary synthetic approaches to

269 "liking"/"disliking" elicited by sucrose or quinine tastes after D-Ala2-N-Me-Phe4-Glycol5-enkephalin

270 our hypothesis, GLX had a greater effect on quinine than cycloheximide (mean shift of 1.02 vs. 0.27

271 immunized with purified human GPIIb/IIIa and quinine that recognize the N terminus of the GPIIb beta

272 For quinine, the peak association was centered in a region t

273 In contrast, in response to quinine, there was a cluster of double-labeled neurons w

274 sence of two sets of organocatalysts, viz. a quinine-thiourea and a quinine-squaramide.

275 The quinine-thiourea provided the products possessing an alp

276 nonvolatile repellents tested, ranging from quinine to denatonium, lobeline, and caffeine.

277 ) and 90% (Accelerate 2), with a switch from quinine to injectable artesunate for management of sever

278 ption despite punishment, assessed by adding quinine to the alcohol solution, compared with control r

279 monstrate specific, high-affinity binding of quinine to the complementarity-determining regions (CDRs

280 Because no detectable binding of quinine to the target integrin could be demonstrated in

281 ucleoside, in a process mediated by HATU and quinine, to deliver the coupled product in high chemical

282 ith hydroxychloroquine toxicity, and 25 with quinine toxicity.

283 Quinine treated but could not control malaria; its use r

284 ital discharge rates between artesunate- and quinine-treated patients.

285 d significantly, from 26.2% (n = 107) before quinine treatment to 46.3% (n = 54) after therapy (P = .

286 ms4760-1 among parasites before versus after quinine treatment was determined by direct sequencing.

287 nalyzed to compare outcomes of artesunate vs quinine treatment.

288 idine, and type II cations (e.g., quinidine, quinine, verapamil, and rhodamine123) are also PMAT inhi

289 Quinine was determined in plasma samples after drinking

290 ardly learned and were weakly expressed when quinine was mixed with NaCl, and generalizations from mu

291 ity (K(D) approximately 2.2 x 10(-)(6)) when quinine was present.

292 However, CTAs to quinine were hardly learned and were weakly expressed wh

293 estive and aversive responses to sucrose and quinine were similar between groups.

294 ol ova-albumin challenge, and chloroquine or quinine were tested in both prophylactic and treatment m

295 m sucrose, 0.01 m citric acid, and 0.0001 m quinine) were delivered for five consecutive licks inter

296 ies of quinolines, including chloroquine and quinine, were identified as potent pigmentation inhibito

297 mely, teicoplanin, cyclofructan, silica, and quinine, were packed in 0.5-cm-long columns for separati

298 5% in Africa and 34.7% in Asia compared with quinine, whereas adjunctive interventions have been unif

299 Second, quinine, which potently inhibited TWIK-1 (IC(50) = 85 mi

300 rience (the pairing of the aversive chemical quinine with color or with odor).