ライフサイエンスコーパス: radioactivity

1 the major clearance and excretion routes for radioactivity.

2 Fukushima lack international warnings about radioactivity.

3 terranean habitats with contrasted levels of radioactivity.

4 r ex vivo determination of tissue-associated radioactivity.

5 gh radiochemical yield, purity, and specific radioactivity.

6 environment in the context of this elevated radioactivity.

7 and biliary excretion (CLbile) clearances of radioactivity.

8 chemistry in the assessment of environmental radioactivity.

9 le in vivo and the lowest renal retention of radioactivity.

10 zation in vitro of the total cell-associated radioactivity.

11 0% +/- 4.6% to 85.6% +/- 11.7% of introduced radioactivity.

12 ting cocktails for measurements of low (14)C radioactivity.

13 aerodynamic diameter; PM(2.5)) and particle radioactivity.

14 ten hindered by the presence of a high bowel radioactivity.

15 ously) resulted in a uniform distribution of radioactivity.

16 uminous supernovae, which are not powered by radioactivity.

17 th postmortem myocardial tissue well-counted radioactivity.

18 ochemical purity, and >90 GBq/mumol specific radioactivity.

19 uptake of the 2 tracers and clearance of the radioactivity.

20 brain and fetal liver distribution of (11)C-radioactivity.

21 27 min after injection in regions with high radioactivity.

22 oduced in high purity and with high specific radioactivity.

23 d the (3)H-labeled ligand with high specific radioactivity.

24 erning the natural emission and transport of radioactivity.

25 lator implantation independently of particle radioactivity.

26 -day moving averages of PM(2.5) and particle radioactivity (2 single-pollutant models and a 2-polluta

27 ration of both probes resulted in high tumor radioactivity accumulation (16.5 +/- 2.8 and 8.6 +/- 1.3

28 ere with high radiation absorbed doses, high radioactivity accumulation by liver and kidney should be

29 CO2 release amounted to 17.4% of the initial radioactivity after 63 days of incubation.

30 examined the relationship between different radioactivities and compared our measurements to those m

31 ies have found associations between particle radioactivity and adverse health outcomes, including cha

32 C) method performs a joint reconstruction of radioactivity and attenuation from the emission data to

33 The administered radioactivity and effective radiation doses absorbed wer

34 psy, all tissues were assessed for levels of radioactivity and evaluated for histologic abnormalities

35 the spatiotemporal distribution of particle radioactivity and factors influencing its variability ha

36 ted non-SLNs, we assayed all lymph nodes for radioactivity and fluorescence intensity.

37 The advantages of electrochemistry over radioactivity and fluorescence make this assay an access

38 l blood was sampled for measurement of blood radioactivity and metabolite analysis.

39 a between 1953 and 1963 dispersed long-lived radioactivity and nuclear weapons debris including pluto

40 EWOD, starting with approximately 333 MBq of radioactivity and obtained up to 52 MBq (non-decay-corre

41 degradation of cardiac SPECT by extracardiac radioactivity and partial-volume effect.

42 nt radiochemical yield, purity, and specific radioactivity and possesses binding specificity in relev

43 itable radiochemical yield and high specific radioactivity and purity.

44 over 4 h with sampling of venous bloods for radioactivity and radioactive metabolite quantification.

45 a positive correlation between the level of radioactivity and the probability of G to T (and complem

46 ctivity was used as a surrogate for particle radioactivity and was measured from several monitoring s

47 le sediment-bound residue (40-60% of applied radioactivity) and smaller amounts of photoproducts.

48 lay unique characteristics (i.e., magnetism, radioactivity, and luminescence), often with biological

49 Blood levels of radioactivity, antibodies, shed serum HER2, and toxicity

50 fter intravenous injection of (18)F-AZD4694, radioactivity appeared rapidly in brain.

51 activity declined over 2 h, of the remaining radioactivity, approximately 90% was due to parent (18)F

52 HTS platforms based on radioactivity are expensive, both in terms of reagent co

53 PET data, using metabolite-corrected plasma radioactivity as the input function.

54 determined by PET quantification and tissue radioactivity assay.

55 Boston from 2005 to 2006 and calculated the radioactivities at the time of air sampling retrospectiv

56 he only sites with prominent accumulation of radioactivity at 4 h after injection.

57 Conclusion: The detection of radioactivity at a variety of security checkpoints at pu

58 l lymph nodes retain greater than 95% of the radioactivity at both 1 and 36 h after injection.

59 evolutionary discoveries about radiation and radioactivity at the end of the century that ushered in

60 Radioactivity at the T cell injection sites and in the t

61 Current PGT assays include radioactivity-based methods, which rely on liquid-liquid

62 livery resulting in sub-cytotoxic amounts of radioactivity being delivered to the tumour.

63 ved under ePLND or after unmasking contained radioactivity but no fluorescence.

64 ed under ePLND or after unblinding contained radioactivity but no fluorescence.

65 on Earth are exposed to low doses of natural radioactivity but some habitats are more radioactive tha

66 Moreover, higher doses of radioactivity can be delivered while minimizing damage t

67 It has been found that radioactivity can hinder aggregation of particles becaus

68 Radioactivity can influence surface interactions, but it

69 (64)Cu-FBP8 administration to further assess radioactivity clearance.

70 Blood radioactivity cleared quickly, whereas myocardial uptake

71 mistry of the aorta revealed that (68)Ga-FOL radioactivity co-localized with Mac-3-positive macrophag

72 ned higher concentrations of salts and total radioactivity compared to prefracturing fluids.

73 but ex vivo CLI was also correlated with the radioactivity concentration (r(2) = 0.35-0.94).

74 scans were also analyzed to determine tissue radioactivity concentration (TRC) from 3-dimensional reg

75 -counter blood data and used to estimate the radioactivity concentration at the time of each PET acqu

76 Metabolite-corrected plasma radioactivity concentration fit a biexponential (half-li

77 g thoracic aorta to estimate the PET-derived radioactivity concentration in blood.

78 Current assessments of the radioactivity concentration in liquid wastes focus on a

79 cular organs demonstrated a slow decrease in radioactivity concentration over time consistent with cl

80 The percentage change per minute in radioactivity concentration was calculated in high- and

81 Tumor detection and radioactivity concentration within the urinary bladder w

82 with furosemide presented with lower SUV and radioactivity concentration within the urinary bladder.

83 Accurate predictions of radioactivity concentrations are critical for estimating

84 This system can quantitate samples with radioactivity concentrations as low as 114 MBq/mL (3.1 m

85 However, the use of radium alone to predict radioactivity concentrations can greatly underestimate t

86 1], where CROI and CREF are the mean of the radioactivity concentrations from 90 to 120 min after tr

87 We investigated the contribution to radioactivity concentrations from naturally occurring ra

88 Image-derived radioactivity concentrations in the descending aorta wer

89 ity coefficients were derived from the fetal radioactivity concentrations measured on the images for

90 Clinically relevant radioactivity concentrations of alpha- and beta-emitters

91 Tumor radioactivity concentrations were calculated from SPECT

92 Tumor radioactivity concentrations were high at 1 h after inje

93 s: The PET-derived and gamma-counter-derived radioactivity concentrations were linearly related, with

94 an R (2) of 0.985, over a range of relevant radioactivity concentrations.

95 e parent fraction and plasma and whole-blood radioactivity concentrations.

96 ocedures, and the ability to quantify tissue radioactivity concentrations.

97 demonstrated that 80-95% of brain uptake of radioactivity constituted binding of the radiotracers to

98 Time-radioactivity curves were extracted in 11 manually delin

99 h-old WT mice and found that, although total radioactivity declined over 2 h, of the remaining radioa

100 Hepatic and splenic radioactivity decreased over time.

101 ogues via liquid chromatography coupled with radioactivity detection and mass spectrometry (LC-RAD/MS

102 y assays are discontinuous, involving either radioactivity detection or coupling with antibodies.

103 In this work we present specific radiocarbon radioactivity determinations and based on them estimatio

104 h account for more than 99% of the total TRU radioactivity disposed and scheduled for disposal in the

105 led enzyme activity-dependent changes in the radioactivity distribution in the liver and tumors.

106 In the FaDu mouse model, radioactivity distribution profiles were overlapping irr

107 wis-brown Norway [LBN] to Lewis), whole-body radioactivity distribution was assessed in vivo by small

108 fusion imaging protocol that merges data on radioactivity distribution with physiologic liver mappin

109 per pumps in the 3 models was not related to radioactivity distribution.

110 camera images, to determine the administered radioactivity dose and whether a therapeutic dose can be

111 nding to an SA of 5.7 kBq/pmol for the given radioactivity dose, and 10% occupancy was reached at 1.5

112 In the single-pollutant model of particle radioactivity, each interquartile range increase in part

113 ADx-001 is attractive because of the lack of radioactivity, ease of distribution, long shelf life, an

114 ant increase of the tumor-to-kidney ratio of radioactivity, enabling for the first time, to our knowl

115 ossible to assess the retrospective particle radioactivity exposure for future epidemiological studie

116 ctivity was expressed as the (11)C-verapamil radioactivity extraction ratio ((11)C-verapamil brain di

117 ligand gave high early whole-brain uptake of radioactivity, followed by a brief fast decline and then

118 The alga highly incorporated radioactivity following (14)C-EE2 exposure.

119 says indicated that intracellularly retained radioactivity for (18)F-RL-I-5F7 was similar to that for

120 ach interquartile range increase in particle radioactivity for a 2-day moving average was associated

121 ) can contribute to an increase in the total radioactivity for more than 100 years.

122 However, natural radioactivity found in the large volumes of "produced fl

123 +/- 13%, P = 0.008), influx rate constant of radioactivity from plasma into brain (58% +/- 26%, P = 0

124 atment resulted in an increased clearance of radioactivity from the brain as reflected by significant

125 atment resulted in an increased clearance of radioactivity from the brain as reflected by significant

126 During in vivo tests, fluorescence and radioactivity from the MOMIA were colocalized in spatial

127 released only low portions of nonextractable radioactivity giving evidence of strongly incorporated r

128 ymph node to removal of all lymph nodes with radioactivity greater than 10% of the hottest lymph node

129 o resection of all sentinel lymph nodes with radioactivity greater than 10% of the hottest lymph node

130 onic transit (defined as geometric center of radioactivity >/=2 on day 3), but not gastric emptying,

131 modulators led to increased levels of brain radioactivity; however, dynamic PET did not show differe

132 In cancer xenografts, (99m)Tc-TCP-1 radioactivity (%ID/g) was 1.01+/-0.15 in the absence of

133 dized uptake value ratio (SUVR, the ratio of radioactivity in a cerebral region to that in the cerebe

134 P and (125)I-2P) showed similar retention of radioactivity in both tumor and major organs except kidn

135 The accumulation of radioactivity in different organs after intravenous admi

136 and sacrificed after the final PET scan, and radioactivity in dissected tissues was measured with a g

137 ges allowed the visualization of accumulated radioactivity in KB tumors and in the kidneys.

138 onstrated that a very high proportion of the radioactivity in monkey brain was bound specifically and

139 Results: Uptake of radioactivity in monkey brain was high (~5 SUV) and foll

140 payload EPI, (125)I-labeled EPI showed lower radioactivity in normal organs and tumor at 48h and 144h

141 n previously assumed, with the major part of radioactivity in plasma consisting of (177)Lu-labeled me

142 Ex vivo measurements showed that radioactivity in rat brain at 30 min after radioligand i

143 idic counting system to monitor rodent blood radioactivity in real time, with high efficiency and sma

144 However, residual radioactivity in the blood and normal organs was consist

145 Metabolite analysis showed that most radioactivity in the brain comprised unmetabolized (11)C

146 abolite analysis showed that the majority of radioactivity in the brain was composed of unmetabolized

147 ously) resulted in a uniform distribution of radioactivity in the brain.

148 h time post-injury: the ratio of accumulated radioactivity in the diseased and healthy cardiac tissue

149 pH of 5.0-5.5, contained greater than 98% of radioactivity in the form of pertechnetate ion, and was

150 Zr-BVDFO resulted in gradual accumulation of radioactivity in the ipsilateral hemisphere, with 9.16 +

151 Radioactivity in the lipid fraction, as compared with th

152 radiochemical yield of 14% +/- 7%, specific radioactivity in the range of 888-3,774 GBq/mumol, and a

153 patients because of lack of interference by radioactivity in the small intestine.

154 PET imaging showed that the accumulation of radioactivity in the treated tumors decreased 76% at 75

155 ct (11)C-PS13 accounted for more than 80% of radioactivity in the tumor, with less than 20% in plasma

156 tion studies show a rapid and high uptake of radioactivity in the tumor, with uptake levels reaching

157 gamma-counting of radioactivity in the tumors positively correlated with c

158 lacridar, the brain PET signal corrected for radioactivity in the vasculature was low (~0.1 standardi

159 Radioactivity in the VOIs, normalized to whole-brain rad

160 Two photoproducts accounted for 15-30% of radioactivity in the water column at the end of the 63-d

161 etabolites individually accounted for <7% of radioactivity in the water or sediment.

162 The retention of radioactivity in tumors after administration of (64)Cu-A

163 This study demonstrated that radioactivity in tumors and the tumor-to-normal brain ra

164 There was no detectable radioactivity in urine.

165 Quantitative measurements of (18)F radioactivity in volumes of interest over target organs

166 ter injection to assess metabolite-corrected radioactivity in whole blood, plasma, and urine.

167 (HD), with approximately the same amount of radioactivity, in separate investigations 1 wk apart.

168 n average by 60% and 30%, respectively, when radioactivity increased by a factor of three.

169 Radioactivity-induced charging mechanisms have been inve

170 The radioactivity-induced surface charging is highly influen

171 clude that even low doses of natural bedrock radioactivity influence the mutation rate possibly throu

172 de nuclear reactors, verified the long-lived radioactivity inside our planet, and informed sensitive

173 The large discharge of radioactivity into the northwest Pacific Ocean from the

174 unction, the distribution of (11)C-verapamil radioactivity into these compartments is limited by bloo

175 Particle radioactivity is a property of airborne particles caused

176 e results showed that the majority of PM(10) radioactivity is associated with that of PM(2.5) samples

177 nd heterogeneous surface potential caused by radioactivity is reported.

178 Brain radioactivity (KBq/mL) was measured in summation images

179 The radioactivity level in tumors 4 h after injection was 10

180 iation dose for each boar was estimated from radioactivity levels in each animal's home range combine

181 mples, as well as to compile a data base for radioactivity levels in that region.

182 tration of [(11)C]PD153035 greatly increased radioactivity levels in the adjacent tumor compared with

183 In the years after the accident, the radioactivity levels rapidly declined due to radioactive

184 1) levels of albumin nanoparticle-associated radioactivity located within the lung tissue (23.3+/-4.7

185 reases overall radiolabeling time and causes radioactivity loss.

186 Their radioactivity makes such compounds interesting candidate

187 plasma, and urine samples were collected for radioactivity measurement and plasma radiotracer metabol

188 erial venous blood samples were obtained for radioactivity measurement and radiometabolite analysis.

189 plasma, and urine samples were collected for radioactivity measurement and radiotracer stability.

190 dividual (131)I doses estimated from thyroid radioactivity measurements and were screened according t

191 In addition, ex vivo radioactivity measurements of blood and of biopsies from

192 Radioactivity measurements showed predominant accumulati

193 immediately after injection and blood-based radioactivity measurements to determine the time course

194 ) were achieved from starting (18)F-fluoride radioactivities of 40-44 GBq.

195 Lower radioactivities of I-131 could provide similar outcomes

196 sional doses being noted using fixed 100 mCi radioactivities of I-131, no dose-effective relationship

197 adiochemical yield and purity, with specific radioactivities of more than 83.92 GBq/mumol.

198 e of 7.2% (range, 4.4%-9.0%) of the injected radioactivity of (18)F-rhPSMA-7.3 was excreted into urin

199 al (124)I-BTT-1023 PET studies with injected radioactivity of 0.5-0.7 MBq/kg may be justified.

200 ((89)Zr-BVDFO) was prepared with a specific radioactivity of 81.4 +/- 7.4 MBq/mg (2.2 +/- 0.2 muCi/m

201 However, the influence of UOGD on the radioactivity of ambient particulate is not well underst

202 bismuth, and polonium isotopes, to the total radioactivity of hydraulic fracturing wastes.

203 Radioactivity of nest samples was in the range 479-143,3

204 Another interesting feature is the radioactivity of some compounds, which makes them excell

205 With this approach, the specific radioactivity of the alloyed gold nanoparticles could be

206 ermoluminescent dosimeters, and by measuring radioactivity of the nest material.

207 f amino acid/proteins of the samples and the radioactivity of the supernatants obtained after fining

208 s, has been employed to study the effects of radioactivity on particle aggregation kinetics in air.

209 en performed to investigate the influence of radioactivity on surface charging and aggregation kineti

210 Yet, documenting the influence of natural radioactivity on the evolution of biodiversity is challe

211 y with human tissue revealed accumulation of radioactivity only in AD brain tissues in which Abeta pl

212 amples, limit this work because they rely on radioactivity or fluorescence and require bulky instrume

213 Limited redistribution of radioactivity out of the peritoneal cavity to circulatin

214 Besides total radioactivity, plasma samples were analyzed by radio-hig

215 We collected the ambient particle radioactivity (PR) measurements of RadNet, a nationwide

216 ancer cells, with retention of intracellular radioactivity predicted to occur via a putative (18)F-FP

217 ed radiochemical yield of up to 5% and molar radioactivities ranging from 20 to 250 GBq/mumol.

218 ategies decrease the circulation time of the radioactivity, reduce the uptake of the radionuclide in

219 opulations in the same tissue may contain no radioactivity, referred to as labeled and unlabeled cell

220 The large inventory of radioactivity released during the March, 2011 Fukushima

221 Radioactivity released from disasters like Chernobyl and

222 medicine and following accidental/malicious radioactivity releases.

223 imately 27.0% of the initially applied (14)C-radioactivity remained in the culture media at the concl

224 of radioactivity was observed, whereas most radioactivity remained trapped in the endocrine cells.

225 At 30 min after injection, 37% of plasma radioactivity represented unmetabolized (18)F-GE-179.

226 (37.2% +/- 4.0% and 37.6% +/- 4.1% of total radioactivity, respectively).

227 These levels correspond to 25 and 25 muBq/kg radioactivity, respectively.

228 or (238)U, corresponding to 4 and 25 muBq/kg radioactivity, respectively.

229 ffinity binders provided 2-fold-higher tumor radioactivity retention at 24 h.

230 showed increasing preblocking of whole-brain radioactivity retention with increasing dose (0.01-3.00

231 ctron antineutrinos from terrestrial natural radioactivity, reveal the amount of uranium and thorium

232 dge of the transport of the Fukushima marine radioactivity signal to the eastern North Pacific.

233 In addition, the radioactivity signal within the urinary bladder was lowe

234 Results: The pulmonary kinetics of radioactivity significantly differed between wild-type a

235 We now aim to establish the lower limit of radioactivity that can be administered to patients and t

236 rves revealed a steady accumulation of tumor radioactivity that plateaued from 40 to 60 min and was s

237 ic chemistry laboratories, the importance of radioactivity, the basics of Np decay and its ramificati

238 We found that with higher levels of particle radioactivity, the effect of PM(2.5) on VAs is reduced.

239 s retained greater than 52% and 70% of their radioactivity through 60 days in the prostate and pancre

240 r have been limited by the low abundance and radioactivity, thus requiring huge sample sizes.

241 Radioactivity time integrals are more robustly estimated

242 in the field: from simple inert carriers of radioactivity to activatable nanomaterials for both diag

243 The partitioning of radioactivity to different organs and tissues was measur

244 r results indicated that the distribution of radioactivity to EGFR-overexpressing tumors was affected

245 To link the radioactivity to possible health impairments, we calcula

246 ouse tumor model (Panc-02) that RL delivered radioactivity to the metastases and less abundantly to p

247 measuring the molar activity (A(m); ratio of radioactivity to total mass; Bq/mol) of a radiotracer do

248 he recent transport history of the Fukushima radioactivity tracer plume through the northeast Pacific

249 retention, correspondingly, of internalized radioactivity under hypoxic conditions relative to 34.8%

250 No evidence of radioactivity uptake in bone was observed.

251 The radioactivity uptake in joints was quantified and correl

252 The radioactivity uptake in nontumor tissue was higher than

253 croPET studies affirm that this differential radioactivity uptake in spinal cords of EAE versus contr

254 Early (6-24 h) radioactivity uptake in the gastrointestinal region was

255 Radioactivity uptake in the kidneys, liver, salivary gla

256 abeling with [(99m)Tc(CO)3](+) but increases radioactivity uptake in the liver.

257 Besides, significant radioactivity uptake in the pituitary gland was observed

258 analysis with cerebellar reference input, as radioactivity uptake ratios between the frontal cortex (

259 High radioactivity uptake was seen in liver, followed by sple

260 in rhesus monkey, [(18)F]11 gave high brain radioactivity uptake, reflecting the expected distributi

261 to analyze spatiotemporal trends in particle radioactivity using measurements from the EPA RadNet sys

262 Results: Mean administered radioactivity was 1,469 +/- 428 MBq (range, 847-2,185 MB

263 The mean administered radioactivity was 7.5 GBq/cycle.

264 es to assess regional distribution of (89)Zr radioactivity was also performed.

265 Plasma and urine radioactivity was assessed over 24 hours.

266 In (14)C-SMX trials, (14)C-radioactivity was detected in both extractable and bound

267 Distribution of radioactivity was determined via PET at 60 min after rad

268 determine whether the increased tumor (64)Cu radioactivity was due to increased cellular uptake of (6

269 on between SPECT-quantified and well-counted radioactivity was fair (R(2) = 0.19, y = 0.50x + 0.05, P

270 itoneally into ApoE knockout mice (n=6), and radioactivity was measured using a gamma counter.

271 Less than 3% of applied radioactivity was mineralized to (14)CO2.

272 esent in blood ( approximately 40% of plasma radioactivity was nonparent 3 h after injection), no sig

273 In the exocrine cells, a rapid efflux of radioactivity was observed, whereas most radioactivity r

274 Radioactivity was predominantly cleared via the hepatobi

275 Most of the radioactivity was retained in the circulation system at

276 Tumor-associated radioactivity was significantly higher for (18)F-hGTS13

277 Brain radioactivity was strikingly higher in the LPS-treated m

278 ivity in the VOIs, normalized to whole-brain radioactivity was taken as a surrogate index of glucose

279 demonstrated that intracellular retention of radioactivity was up to 1.5-fold higher for *I-SGMIB-Nan

280 ral ABCB1 activity, the elimination slope of radioactivity washout from the brain (k (E,brain)) was c

281 ral ABCB1 activity, the elimination slope of radioactivity washout from the brain (kE,brain) was calc

282 was 77% higher and the elimination slope of radioactivity washout from the lungs (k (E,lung)) was 70

283 Tissue (18)F radioactivities were determined from quantitative analys

284 Total time integrals of radioactivity were computed for each model and averaged

285 rkably, little fractions of the internalized radioactivity were detected in the blood and muscle tiss

286 The highest mean levels of gray matter radioactivity were seen in the putamina and peaked at 7.

287 mean absorbed dose per unit of administered radioactivity were the adrenals (0.1835 mSv/MBq), the ki

288 tate cancer xenografts with increased (64)Cu radioactivity were visualized previously by PET using (6

289 ssue may contain widely different amounts of radioactivity, whereas other cell populations in the sam

290 We hypothesized that particulate radioactivity, which is due to the attachment of radioac

291 ccounted for 35.8-43.6% of the uptaken (14)C-radioactivity, while bound residues were 56.4-64.2%.

292 ach interquartile range increase of particle radioactivity with a 10% lower odds of a VA event (95% C

293 estimated by multiplying fludeoxyglucose F18 radioactivity with dose coefficients.

294 ximately 3 h to estimate the uptake of (18)F radioactivity with respect to time for the pharmacokinet

295 logic analysis showed good colocalization of radioactivity with TAM-rich areas in tumor sections.

296 ans except the kidneys showed low background radioactivity, with especially low activities in the liv

297 1 and (225)Ac-L1 revealed specific uptake of radioactivity within PSMA+ lesions.

298 Accumulation of radioactivity within the tumor periphery colocalized wit

299 [(18)F]FGlc-FAPI was synthesized with a 15% radioactivity yield and a high radiochemical purity of m

300 yl moiety (11) were radiosynthesised in high radioactivity yields.