ライフサイエンスコーパス: radiosensitization

1 t GW6471 abolish the effect of clofibrate on radiosensitization.

2 repaired before irradiation, would result in radiosensitization.

3 -1 head and neck cancer cells also conferred radiosensitization.

4 om ROS generation leads to curcumin-mediated radiosensitization.

5 ecreased phospho-Akt and was associated with radiosensitization.

6 pect to the mechanisms by which they produce radiosensitization.

7 vity was associated with significant thermal radiosensitization.

8 erally applicable druggable target for tumor radiosensitization.

9 etween these molecules and, in turn, causing radiosensitization.

10 R inhibitors can potentiate cytotoxicity and radiosensitization.

11 vel approach for specific ATM inhibition and radiosensitization.

12 ns for the complexity underlying FTI-induced radiosensitization.

13 and on angiogenesis, tumor oxygenation, and radiosensitization.

14 ted p53 were able to counteract drug-induced radiosensitization.

15 ectable in cells resistant to 17DMAG-induced radiosensitization.

16 lar mechanisms of heat-induced apoptosis and radiosensitization.

17 ing activity is necessary for 17DMAG-induced radiosensitization.

18 defective DNA double-strand break repair and radiosensitization.

19 dioresistance and abrogated miR-125-mediated radiosensitization.

20 HDR as a significant contributor to caffeine radiosensitization.

21 d breaks (DSBs) in the mechanism of caffeine radiosensitization.

22 and DNA-PK as a powerful strategy for tumor radiosensitization.

23 ould provide new molecular targets for tumor radiosensitization.

24 cer cells (HCT116) to IdUrd cytotoxicity and radiosensitization.

25 human colon cancer cells leading to greater radiosensitization.

26 inhibition of ribonucleotide reductase) and radiosensitization.

27 ptor, is examined as a target for tumor cell radiosensitization.

28 al basis for targeting this gene network for radiosensitization.

29 mismatch repair (MMR) would exhibit greater radiosensitization.

30 illing and did not influence AV1Y28-mediated radiosensitization.

31 Fv) directed against Ras proteins results in radiosensitization.

32 ncer cells resistant to TRAIL/Apo2L-mediated radiosensitization.

33 domethacin and is involved in the process of radiosensitization.

34 ls of DNA repair in bladder cancer cells and radiosensitization.

35 d exceeded that reported to achieve in vitro radiosensitization.

36 ue-1 (MLH1)-deficient human cancer cells for radiosensitization.

37 kpoint response is not sufficient to explain radiosensitization.

38 A levels, and consequently, analogue-induced radiosensitization.

39 checkpoint abrogation is not sufficient for radiosensitization.

40 because bromodeoxyuridine was able to induce radiosensitization.

41 ive in HRR, similarly shows reduced caffeine radiosensitization.

42 and MSH2-deficient, drug-resistant cells for radiosensitization.

43 of dThd analogue DNA incorporation and tumor radiosensitization.

44 were consistent with clinically significant radiosensitization.

45 concentrations similar to those that induce radiosensitization.

46 offer a relative sparing of the mucosa from radiosensitization.

47 t correlated closely with those required for radiosensitization.

48 ll killing, a phenomenon termed hyperthermic radiosensitization.

49 ding activity of Ku may lead to hyperthermic radiosensitization.

50 activity did not correlate with hyperthermic radiosensitization.

51 source of molecular targets for glioblastoma radiosensitization.

52 NHEJ) repair and that FBXW7 depletion causes radiosensitization.

53 ed whether PRMT5 provides a target for tumor radiosensitization.

54 eceived cetuximab-based or carboplatin-based radiosensitization.

55 ma, implying a role for MGMT as a target for radiosensitization.

56 y cancer cells to facilitate potent in vitro radiosensitization.

57 were essential for SETDB1 deficiency-induced radiosensitization.

58 mab-based and carboplatin-based regimens for radiosensitization.

59 t that PRMT5 is a tumor selective target for radiosensitization.

60 TP53-mutant cells to ATM inhibitor-mediated radiosensitization.

61 ys might offer a rational strategy for tumor radiosensitization.

62 tigations of the use of FGFR1 inhibitors for radiosensitization.

63 active AKT in GSCs compromised hyperthermic radiosensitization.

64 eveal MKP1 as a novel therapeutic target for radiosensitization.

65 sed nanoparticles for multimodal imaging and radiosensitization.

66 being tested in phase I clinical trials, in radiosensitization.

67 naling and induced cell rounding, leading to radiosensitization.

68 5) and beclin1 increased NVP-BEZ235-mediated radiosensitization.

69 enomic biomarkers of EGFR inhibitor-mediated radiosensitization.

70 focused on the tumor stroma as a target for radiosensitization.

71 ly showed was required for curcumin-mediated radiosensitization.

72 aDu cells nearly abolished curcumin-mediated radiosensitization.

73 tion, impaired G2 checkpoint proficiency and radiosensitization.

74 cell cycle status on EGFR inhibitor-mediated radiosensitization.

75 ation-induced DNA damage play a role in heat radiosensitization.

76 decreases their clonogenicity and results in radiosensitization.

77 ions was sufficient to reverse IDH1-mediated radiosensitization.

78 H2AX/MDC1/53BP1 complex plays a role in heat radiosensitization.

79 ctive drug target for anticancer therapy and radiosensitization.

80 anced G(2)-M arrest, growth suppression, and radiosensitization.

81 umbilical vascular endothelial cell (HUVEC) radiosensitization.

82 RbAp48 overexpression induced radiosensitization (1.5- to 2-fold) when compared with m

83 isomerase I is essential in the induction of radiosensitization: (a) higher concentrations of camptot

84 linked to anticancer, anti-inflammatory, and radiosensitization activities through a mechanism that i

85 IF-1 tumors growing in C3H mice demonstrated radiosensitization after Gd-tex treatment before single

86 RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus i

87 Furthermore, this radiosensitization also carried over to the in vivo situ

88 f DNA repair may play a role in SQAP induced radiosensitization and chemosensitization.

89 Hyperthermia caused apoptosis and radiosensitization and decreased 26S proteasome activity

90 ntegrin dual targeting achieved relapse-free radiosensitization and prevented metastatic escape.

91 imal model of xenograft irradiation produced radiosensitization and prevention of relapse.

92 critical role of TxnRd1 in curcumin-mediated radiosensitization and suggest that TxnRd1 levels in tum

93 reciated role of ferroptosis in p53-mediated radiosensitization and suggest using FINs in combination

94 t (ABT-263) with a gold-shelled liposome for radiosensitization and sustained drug release.

95 is a target involved in indomethacin-induced radiosensitization and that NF-kappaB may be one downstr

96 mation correlated with the magnitude of heat radiosensitization and was modulated by the molecular ch

97 hylation event triggered apoptosis, promoted radiosensitization, and hindered tumorigenicity of radio

98 hibition of TRIP12 expression further led to radiosensitization, and overexpression of TRIP12 was ass

99 e that genetic disruption of CREB results in radiosensitization, and that this effect can be explaine

100 DDFP plus carbogen caused dramatic radiosensitization, and the radiation response of cells

101 IdUrd-related cytotoxicity and/or radiosensitization are correlated with the extent of IdU

102 dermal growth factor receptor inhibition for radiosensitization are put into perspective for larynx c

103 While the degree of GNP-mediated radiosensitization as seen from the in vitro study may b

104 D54 cells were not resistant to radiosensitization because bromodeoxyuridine was able to

105 Ku86 in modulating topoisomerase I-mediated radiosensitization, but not cytotoxicity, in mammalian c

106 down of Akt1, p110alpha, or mTOR resulted in radiosensitization, but not to the same degree as with N

107 on of NPM significantly reduces heat-induced radiosensitization, but reduced NPM level does not alter

108 Radiosensitization by AZD7762 was associated with abroga

109 Radiosensitization by beta-lap was blocked by the NQO1 i

110 ng fraction dose, sequence, and time course; radiosensitization by chemo- and biologic therapy; and t

111 This differential dual mode of radiosensitization by combining IUdR and caffeine-like d

112 Because radiosensitization by dFdCyd has been correlated with it

113 lting from wild-type p53 induction prevented radiosensitization by dFdCyd.

114 ay play an important role in Ad/p16 mediated radiosensitization by enhancing or restoring apoptosis p

115 or several specific genes that may influence radiosensitization by erlotinib including Egr-1, CXCL1,

116 hus, our data indicate a common mechanism of radiosensitization by erlotinib or cetuximab across dive

117 nt role for MLH1 and implicate mismatches in radiosensitization by FdUrd.

118 nd this forms a novel molecular mechanism of radiosensitization by FTI.

119 Radiosensitization by FTIs, however, seemed to involve o

120 (MCF-7 and U-87 MG) were further tested for radiosensitization by Gd-tex under hypoxic conditions.

121 dertook independent efforts to further study radiosensitization by Gd-tex.

122 Previous studies have shown that radiosensitization by gemcitabine is accompanied by simu

123 Radiosensitization by IC87361 was eliminated in SCID tum

124 , Msh2-/- cells are selectively targeted for radiosensitization by IdUrd.

125 onstrate significant tumor and normal tissue radiosensitization by low-dose gemcitabine.

126 ced IUdR-DNA incorporation and IUdR-mediated radiosensitization by partially inhibiting repair (remov

127 between the presence of a KRAS mutation and radiosensitization by the EGFR inhibitors erlotinib and

128 were therefore studied to determine whether radiosensitization by the specific inhibitor of DNA-PK,

129 lling by lapatinib and obatoclax, as well as radiosensitization by this drug combination.

130 s not induce any radiodermatitis, suggesting radiosensitization by vemurafenib.

131 ting that p53 induction was not required for radiosensitization by wortmannin.

132 Despite the reduced radiosensitization, caffeine effectively abrogates check

133 ta3/beta5 integrin cross-talk, but efficient radiosensitization can be achieved by multiple integrin

134 Importantly, MMAE radiosensitization can be localized to tumors by targete

135 GNP)-mediated radiation dose enhancement and radiosensitization can be maximized when photons interac

136 Radiosensitization can result from chemotherapy-induced

137 the MLH1-inactivated cells exhibited greater radiosensitization compared with MMR-wild-type cells [ra

138 inase 1/2 (MEK1/2) blocked curcumin-mediated radiosensitization, demonstrating that the sustained ERK

139 d fibroblasts from AT patients show caffeine radiosensitization despite the checkpoint defects associ

140 This results in tumour growth inhibition and radiosensitization despite the use of a sevenfold lower

141 ox target that contributes to parthenolide's radiosensitization effect in prostate cancer cells.

142 esquiterpene lactone, selectively exhibits a radiosensitization effect on prostate cancer PC3 cells b

143 cl2 : Bax ratio and this caused the enhanced radiosensitization effect.

144 Furthermore, the gastrointestinal radiosensitization engendered by the loss of atm has rec

145 oteins (GLUTs) and possess hypoxia-selective radiosensitization features, are now reported.

146 We have also demonstrated a radiosensitization for several phenotypic endpoints of r

147 investigate the mechanism of the GNP induced radiosensitization, GNP-induced mitochondrial depolarisa

148 wever, predictive genomic biomarkers of this radiosensitization have remained elusive.

149 he resistance of OC-14 cells to heat-induced radiosensitization, hydrogen peroxide, and cisplatin.

150 that senescence is a prominent mechanism of radiosensitization in 45% of cell lines and occurs not o

151 clude that DDX3 inhibition with RK-33 causes radiosensitization in breast cancer through inhibition o

152 PUMA expression elicits profound chemo- and radiosensitization in cancer cells, inhibition of PUMA e

153 of clonogenic survival, we have demonstrated radiosensitization in cell lines with oncogenic H-ras mu

154 ll killing in 96-h viability assays and true radiosensitization in colony formation assays.

155 tyltransferases CREBBP/EP300 as a target for radiosensitization in combination with radiation in cogn

156 topoisomerase I as a biochemical mediator of radiosensitization in cultured mammalian cells by campto

157 hat depleted dATP >90%, also did not produce radiosensitization in D54 cells.

158 ely induce growth suppression, apoptosis and radiosensitization in diverse human cancer cells, withou

159 signaling, HR activity, and AZD1390-mediated radiosensitization in GBM14.

160 investigated the mechanisms of hyperthermic radiosensitization in GSCs by a phospho-kinase array tha

161 in increased IdUrd-induced cytotoxicity and radiosensitization in mammalian cells.

162 excellent in vitro intracellular uptake and radiosensitization in radiation-sensitive HCT116 and rel

163 biquitination patterns of MRE11 and mediated radiosensitization in response to HDAC inhibition.

164 the DNA-PK kinase activity, and hyperthermic radiosensitization in rodent cells immediately after hea

165 cells, inhibits DSBR and induces significant radiosensitization in the absence of E1B-55K.

166 inder vinblastine induced enhanced levels of radiosensitization in the Ku86-deficient cells, Ku86 see

167 tment induced significantly higher levels of radiosensitization in the Ku86-deficient Chinese hamster

168 d both camptothecin-induced cytotoxicity and radiosensitization in the vector-alone, as well as the K

169 changes, suggesting that lomeguatrib-induced radiosensitization in these cells is due to radiation-in

170 exposure to 2DG might be capable of inducing radiosensitization in transformed cells via perturbation

171 r decreased Akt phosphorylation and enhanced radiosensitization in U251MG and U87MG glioblastoma cell

172 nd that deregulation of c-Jun induced marked radiosensitization in vivo and in vitro, which was rescu

173 We found that PARP inhibition increases radiosensitization independent of BRCA1 status for both

174 N4924-induced aneuploidy, G(2)/M arrest, and radiosensitization, indicating a causal effect.

175 role of Ku86 in DNA topoisomerase I-mediated radiosensitization induced by camptothecin in mammalian

176 to uniquely affect topoisomerase I-mediated radiosensitization induced by camptothecin.

177 Knockdown of AIF by shRNA rescues the radiosensitization induced by E4orf6.

178 and bromodeoxyuridine (BrdUrd), and thereby radiosensitization induced by these analogues, indirectl

179 ll effect on HDR, indicating that similar to radiosensitization, inhibition of checkpoint signaling i

180 s correlation suggested that AV1Y28-mediated radiosensitization involved the inhibition of radiation-

181 an important mechanism of celecoxib-induced radiosensitization involves inhibition of COX-2-derived

182 gest a novel mechanism for curcumin-mediated radiosensitization involving increased ROS and ERK1/2 ac

183 hanging tumor oxygenation, establishing that radiosensitization is a component of the response.

184 clinical models demonstrated that l-arginine radiosensitization is a NO-mediated mechanism secondary

185 Both thrombospondin-1- and CD47-dependent radiosensitization is cell autonomous because vascular c

186 We propose that caffeine radiosensitization is mediated by inhibition of stages i

187 The role of thrombospondin-1 in radiosensitization is specific because thrombospondin-2-

188 ignaling may be necessary for 17DMAG-induced radiosensitization, it is not sufficient.

189 ze cells to IR and suggests that therapeutic radiosensitization may only require ATM inhibition for s

190 This decrease correlated with in vitro radiosensitization measured by clonogenic assays, and th

191 d-type cells, FdUrd (IC(50)) did not produce radiosensitization nor did it increase the mutation freq

192 nt to the cytotoxic effect of dFdCyd, and no radiosensitization occurred at any concentration of dFdC

193 Compound 78 demonstrated robust radiosensitization of a broad range of cancer cells in v

194 y (RT); therefore, approaches that result in radiosensitization of basal-like BC are critically neede

195 n-activated protein kinase (MAPK) results in radiosensitization of cancer cells.

196 n ALDH(+) tumor progenitor population and to radiosensitization of cancer cells.

197 or inducing S-phase stasis and promoting the radiosensitization of checkpoint-deficient cancer cells.

198 ibitor of Bmx, LFM-A13, produced significant radiosensitization of endothelial cells as measured by c

199 ition of PARP and ATR resulted in a profound radiosensitization of GSCs, which was of greater magnitu

200 oader kinome, and displayed DNA-PK-dependent radiosensitization of HAP1 cells.

201 51 complex in DNA repair may be a target for radiosensitization of HCC.

202 her EphB4 receptor targeting can enhance the radiosensitization of HNSCC.

203 tumor growth inhibition in athymic mice and radiosensitization of human squamous carcinoma cells tra

204 aveolin-1 inhibitors resulted in significant radiosensitization of malignant glioma cells, which will

205 ry have described increased and preferential radiosensitization of mismatch repair-deficient (MMR(-))

206 o of these compounds were tested in vivo for radiosensitization of murine EO771 mammary gland tumors

207 attenuates NF-kappaB signaling to elicit the radiosensitization of NSCLC.

208 s may protect quiescent tumor cells, whereas radiosensitization of proliferating cells may be caused

209 tric patient-friendly image-guided metabolic radiosensitization of rhabdoid tumors.

210 dow model was used to assess IC87361-induced radiosensitization of SCID and wild-type tumor microvasc

211 1 (TxnRd1) is required for curcumin-mediated radiosensitization of squamous carcinoma cells.

212 (IR) resulted in significant dose-dependent radiosensitization of these cells.

213 t that such treatment might be useful in the radiosensitization of these tumors.

214 Likewise, disulfiram radiosensitization of tumor cells was copper-dependent.

215 ation with decitabine or tacedinaline caused radiosensitization of tumor cells, upregulation of SSTR2

216 IC87361 induced radiosensitization of tumor microvasculature in wild-typ

217 ated PI3K as a potential target for specific radiosensitization of tumors.

218 he therapeutic effectiveness of heat-induced radiosensitization of tumors.

219 53-independent G1-S checkpoint that mediates radiosensitization produced by fluorodeoxyuridine.

220 and neck is less certain, and results of its radiosensitization properties have been variable.

221 and, in preclinical models, it demonstrates radiosensitization properties.

222 We combined the radiosensitization property of topotecan and the specifi

223 cover targets for developing molecular-based radiosensitization protocols for tumors resistant to rad

224 teraction of heat and radiation that lead to radiosensitization remain to be elucidated.

225 he role of DNA repair inhibition in caffeine radiosensitization remains uncharacterized, and it is un

226 xact mechanism by which these events produce radiosensitization remains unknown.

227 Gold nanoparticle radiosensitization represents a novel technique in enhan

228 f MLH1 this concentration produced excellent radiosensitization (RER = 1.6 +/- 0.10 and 1.5 +/- 0.06,

229 on was attenuated in thermotolerant and heat radiosensitization-resistant cells.

230 e, near-infrared (NIR)-excited deep PDT, and radiosensitization, respectively, all of which contribut

231 IdUrd cytotoxicity and radiosensitization result, in part, from induction of DN

232 glioma and endothelial cells (ECs) and that radiosensitization results from inhibiting mTOR signalin

233 isomerase I (TOP1) mediates the induction of radiosensitization (RS) by camptothecin derivatives in m

234 nt studies of fluoropyrimidine (FP)-mediated radiosensitization (RS) have focused on the molecular me

235 derstanding the mechanism of CX-5461-induced radiosensitization should be of value in the potential a

236 y siRNA was not sufficient to ablate miR-890 radiosensitization, signifying that miR-890 functions by

237 yielded results that paralleled the in vitro radiosensitization studies of both single and fractioned

238 The time dependency of R115777-induced radiosensitization suggested that the initial FTI target

239 n induces significant tumor cytotoxicity and radiosensitization, suggesting a potential therapeutic u

240 and Rad3-related kinase (ATR) is a rational radiosensitization target.

241 e, catalytic polypeptide (DNAPK) as an ideal radiosensitization target.

242 , displays significantly diminished caffeine radiosensitization that can be restored by expression of

243 ese findings reveal that p16 participates in radiosensitization through influencing DDR and support t

244 aging and treatment planning, as well as for radiosensitization to improve the therapeutic ratio.

245 Inhibition of HDR and cell radiosensitization to killing shows similar dependence o

246 Radiosensitization to mda-7/IL-24 is dependent on JNK si

247 c synergies of targeted cytotoxic auristatin radiosensitization to stimulate anti-tumor immune respon

248 solution in LNCaP-LN3 cells, suggesting that radiosensitization tracks with the ability of IGF-1R to

249 ernative therapeutic paradigm for ErbB-based radiosensitization using antibodies to restrict radiosen

250 of BER in modulating IdUrd cytotoxicity and radiosensitization using genetically matched Chinese ham

251 that exposure to 2DG causes cytotoxicity and radiosensitization via a mechanism involving perturbatio

252 tunities for mechanism-based selective tumor radiosensitization via accessing of SDRT/ASMase signalin

253 th only (90)Y-TARE, adding microbubble-based radiosensitization via UTMD to (90)Y-TARE in the treatme

254 Radiosensitization was also assessed in vivo using a tum

255 transformed immortalized rat cells, and this radiosensitization was also inhibited by treatment with

256 Radiosensitization was also, in part, dependent upon c-J

257 Ascorbate radiosensitization was associated with an increase in ox

258 Heat radiosensitization was attenuated in 53BP1-null cells, i

259 To investigate whether the PTEN-induced radiosensitization was attributable to impaired sensing

260 Thermal radiosensitization was characterized biochemically and f

261 particles in nude mice bearing HCT116 tumors radiosensitization was evaluated.

262 Radiosensitization was evidenced by decreased clonogenic

263 th radiosensitizers, a significantly greater radiosensitization was found in p53-deficient human tumo

264 The mechanism of action of NP Wtmn radiosensitization was found to be through the inhibitio

265 The mechanism of radiosensitization was investigated in DC3F cells.

266 Previous studies have shown that SQAP radiosensitization was limited to in vivo xenograft mode

267 Radiosensitization was measured by clonogenic survival a

268 Radiosensitization was not affected by androgen dependen

269 No radiosensitization was observed in either case.

270 for 16 h before ionizing radiation exposure, radiosensitization was observed with a sensitizer enhanc

271 POH-induced radiosensitization was partially inhibited in glioma cel

272 gested that the initial FTI target for early radiosensitization was short-lived, and that a p21-direc

273 PARP1-dependent radiosensitization was suppressed by a pan-caspase inhib

274 When this novel concept of radiosensitization was tested in cancer models, small in

275 etermine the effect this might have on tumor radiosensitization, we did tumor regrowth assays with xe

276 To identify the mechanism of this radiosensitization, we examined the level of proteins in

277 cycle redistribution in gemcitabine-mediated radiosensitization, we investigated the role of checkpoi

278 To identify molecular target(s) for radiosensitization, we screened a small interfering RNA

279 To assess the importance of this process in radiosensitization, we used the autophagy inhibitors 3-m

280 To further identify potential mechanisms of radiosensitization, we utilized several assays to determ

281 Interestingly, senescence and radiosensitization were linked to an increase in residua

282 , these effects of caffeine on IUdR-mediated radiosensitization were not found in p53-proficient cell

283 cantly higher levels of camptothecin-induced radiosensitization were observed in the vector-alone sub

284 er H1299 cells caused growth suppression and radiosensitization, whereas overexpression of WT TRAF2 e

285 Radiosensitization with antimetabolites has improved cli

286 Studies of repair pathways involved in radiosensitization with antimetabolites implicate base e

287 of the dATP pool imbalance was important for radiosensitization with dFdCyd, and, therefore, cells de

288 lts demonstrate that MMR deficiency promotes radiosensitization with dFdCyd.

289 e prior to irradiation is also important for radiosensitization with dFdCyd.

290 Although radiosensitization with FdUrd requires dTTP depletion an

291 ator to assess the biological consequence of radiosensitization with gold nanoparticles.

292 ts a translatable strategy to converge focal radiosensitization with targeted immune checkpoint silen

293 lation emerged as a key metabolic target for radiosensitization, with lipoyltransferase 1 (LIPT1) ide