ライフサイエンスコーパス: ragweed

1 ty and erythema skin prick reaction to short ragweed.

2 DNA (AIC) in 25 adults who were allergic to ragweed.

3 anasal challenge (s.i.n.) with either OVA or ragweed.

4 change for boys except an increase in IgE to ragweed.

5 e for SPP in allergic sensitization to short ragweed.

6 [n=429], cypress [412], orchard grass [152], ragweed [127], birch [106], alnus japonica [110], mite (

7 When their PBMC were cultured with ragweed Ag (RA), peak IgE responses occurred on day 10;

8 e were immunized and challenged with a short ragweed Ag extract, known to induce a selective eosinoph

9 During the entire season, ragweed AIT of 1.5, 6, and 12 Amb a 1-U reduced TCS by 1

10 During peak ragweed season, ragweed AIT of 1.5, 6, and 12 Amb a 1-U reduced TCS by 9

11 ximately 52 weeks of daily self-administered ragweed AIT of 1.5, 6, or 12 units of Ambrosia artemisii

12 In this trial, ragweed AIT of 12 Amb a 1-U was effective and tolerable

13 Here, we present structures of methylated ragweed allergen Amb a 8, Amb a 8 in the presence of pol

14 studies with TLR-9 vaccines conjugated to a ragweed allergen demonstrate that they reduce symptoms o

15 mg/day for 3 days before and 13 days during ragweed allergen immunization) in BALB/c and C57BL/6 mic

16 ty and efficacy of a sublingual standardized ragweed allergen immunotherapy liquid extract for the tr

17 that permitted daily self-administration of ragweed allergen immunotherapy.

18 xposing participants with ragweed allergy to ragweed allergen in an environmental exposure chamber mo

19 have induced eosinophilic peritonitis using ragweed allergen in P-selectin-deficient, intracellular

20 ger a seasonal increase in IgE antibodies to ragweed allergen in the immunotherapy group after two ye

21 ffects of intranasal challenge with DEP plus ragweed allergen on local humoral immune responses.

22 The ragweed allergen repertoire has been recently expanded w

23 Patients sensitive to the ragweed allergen were challenged intranasally with aller

24 TRGTT motif prevented conalbumin-induced and ragweed allergen-induced allergic inflammation in mice.

25 ized, placebo-controlled crossover trial, 19 ragweed allergen-sensitive subjects who had previously p

26 hil recruitment, and decreased the number of ragweed allergen-specific IgE-producing cells.

27 nifestations of asthma in mice sensitized to ragweed allergen.

28 and challenged them intranasally with short ragweed allergenic extract (SRW).

29 Ragweed allergens affect several million people in the U

30 The results suggest that ragweed allergens associated with lesser IgE reactivity

31 s for T cell and IgE responses for the other ragweed allergens did not correlate.

32 To date, only two ragweed allergens, Amb t 5 and Amb a 11, have their stru

33 ent of the hierarchy of T cell reactivity in ragweed allergens, which is distinct from that observed

34 ) (on Days 1, 2, 9, and 16) in three groups: ragweed allergic asthmatics with dual phase airway react

35 n an additional 11 American and 14 Slovakian ragweed allergic donors.

36 involved in the diverse T-cell responses in ragweed allergic individuals.

37 (group 1, 3, 4, 5, 8 and 11) in 20 American ragweed allergic patients determined by FluoroSpot and p

38 g-term clinical efficacy in the treatment of ragweed allergic rhinitis.

39 used a segmental Ag challenge (SAC) model in ragweed-allergic asthmatics and nonasthmatic patients an

40 he GCR binding affinity (Kd) was observed in ragweed-allergic asthmatics during ragweed pollen season

41 characterized T cell responses from atopic, ragweed-allergic subjects to Amb a 1, Amb a 3, Amb a 4,

42 dred twenty-eight patients with a history of ragweed allergy and positive skin prick test responses t

43 y contribute to the increasing prevalence of ragweed allergy in Lombardy plain.

44 estion induced by exposing participants with ragweed allergy to ragweed allergen in an environmental

45 s revealed that 50 (54%) of 92 patients with ragweed allergy were sensitized to a 37-kDa allergen dis

46 ity to activate basophils from patients with ragweed allergy, were confirmed.

47 ional trial of this therapeutic modality for ragweed allergy.

48 for molecule-based diagnosis and therapy for ragweed allergy.

49 era from 92 American or European donors with ragweed allergy.

50 Intranasal challenge with ragweed alone induced inconsistent and low levels of muc

51 Ragweed alone stimulated the production of IL-4 (0.6 ng/

52 As compared with challenge with ragweed alone, challenge with both DEP and ragweed induc

53 ophagoides farinae, dog, cat, timothy grass, ragweed, Alternaria alternata, egg, peanut, milk, and Ge

54 pitopes and homologous peptides from western ragweed (Amb p), giant ragweed (Amb t) and mugwort (Art

55 peptides from western ragweed (Amb p), giant ragweed (Amb t) and mugwort (Art v) were investigated in

56 ic-related pollution on the allergenicity of ragweed (Ambrosia artemisiifolia L.) pollen through a fi

57 range of a globally invasive species, common ragweed (Ambrosia artemisiifolia L.), from a temperature

58 Short ragweed (Ambrosia artemisiifolia) allergies affect more

59 By using the common ragweed (Ambrosia artemisiifolia) as a model invader, ou

60 llen allergy in humans, focusing upon common ragweed (Ambrosia artemisiifolia) in Europe.

61 Allergy to pollen from short ragweed (Ambrosia artemisiifolia) is a serious and expan

62 Ragweed (Ambrosia artemisiifolia) is a strong elicitor o

63 Allergy to the short ragweed (Ambrosia artemisiifolia) pollen is a major heal

64 to simulate the invasion of Europe by common ragweed (Ambrosia artemisiifolia), a globally invasive p

65 s (dust mite (Dematophagoides farinae), cat, ragweed (Ambrosia artemisiifolia), and timothy grass (Ph

66 Ragweed (Ambrosia artemisiifolia), the major cause of la

67 Here we report that duration of the ragweed (Ambrosia spp.) pollen season has been increasin

68 h OVA but also with two unrelated allergens (ragweed and BSA) induced Vgamma4(+) cells capable of sup

69 g PBMC from atopic asthmatics with allergen (ragweed and cat) versus Candida albicans.

70 Ragweed and mugwort are closely related weeds that repre

71 IgE to mite and cat and decreases in IgE to ragweed and timothy from 2 to 4 years of age, whereas th

72 (controls) were cultured in the presence of ragweed and/or chitin for 3 days (recall responses).

73 on-interventional studies of SQ grass, tree, ragweed, and house dust mite (HDM) SLIT tablets were ide

74 ity to the aeroallergens Der P 1 and 2, cat, ragweed, and mouse was compared in cases and controls.

75 lences of sensitization to Der p 1, Der p 2, ragweed, and mouse were low and similar in the two group

76 nd Ole e 1 (23.2%) followed by grass pollen, ragweed, and mugwort allergens.

77 hay-fever symptoms, skin-test sensitivity to ragweed, and sensitivity to bronchial challenges and inc

78 We conclude that ragweed antigen causes neutrophil recruitment into the a

79 fluid (BALF) before and 24 h after segmental ragweed antigen challenge in 18 asthmatic subjects at ba

80 We administered ragweed antigen to an isolated, superfused tracheal segm

81 a associated with natural populations of the ragweed aphid, Uroleucon ambrosiae.

82 Aeroallergens such as Amb a I from short ragweed are important in the development of allergic air

83 Although sunflower and giant ragweed are primary hosts of D. texanus, they began colo

84 nsins such as Art v 1 (mugwort) and Amb a 4 (ragweed) are pivotal allergens in pollen-food syndromes,

85 l challenges and increased IgG antibodies to ragweed as compared with the placebo group; there was no

86 a disease, "pollen" as a disease cause and "ragweed" as a plant was needed to fully assess the polle

87 For regionally occurring pollen allergens (ragweed, birch, cypress), IgE sensitization was signific

88 The model predicts the region in which ragweed can reach reproductive maturity before frost kil

89 Among subjects challenged with ragweed, cat dander, or house dust mite, there were no d

90 t to eosinophil peritoneal recruitment after ragweed challenge.

91 hmatic serum and bronchoalveolar lavage from ragweed challenged animals on the BMSCs in vitro.

92 BAL fluid compared to the OVA-sensitized and ragweed-challenged or nonsensitized mice.

93 Ragweed/chitin stimulation resulted in significant decre

94 l cross-sectional area (A(min)) after bolus (ragweed) complete nasal allergen challenge at screening

95 er, ash, birch, hazel, grasses, mugwort, and ragweed) considering personal sensitization and exposure

96 Moreover, ragweed did not affect the integrity of the intestinal e

97 ll responses correlated with conservation of ragweed epitopes with sequences of other well-known alle

98 r adults with asthma exacerbated by seasonal ragweed exposure had positive effects on objective measu

99 notherapy for asthma exacerbated by seasonal ragweed exposure.

100 r airway challenge with nebulized Amb a I or ragweed extract in mice sensitized to Amb a I or ragweed

101 f bronchial epithelial cells stimulated with ragweed extract only if adenosine was present.

102 eed extract in mice sensitized to Amb a I or ragweed extract, respectively.

103 were randomly assigned to receive placebo or ragweed-extract immunotherapy in doses that increased we

104 (PBMCs) from donors positive for IgE towards ragweed extracts after in vitro expansion for secretion

105 Ragweed extracts contain five different isoforms of the

106 Ragweed extracts contained all known allergens and isoal

107 Subjects were then challenged with grass or ragweed extracts on each inferior turbinate.

108 The allergen content of ragweed extracts was determined by mass spectrometry and

109 Ragweed frequently causes seasonal allergies in North Am

110 Common ragweed has been spreading as a neophyte in Europe.

111 studied blood eosinophils from patients with ragweed hay fever.

112 n cells (4 x 106 cells/ml) isolated from the ragweed-immunized mice (controls) were cultured in the p

113 These ragweed-immunized mice were given ragweed intratracheall

114 orms might be a more attractive strategy for ragweed immunotherapy.

115 icited after out-of-season exposure to short ragweed in a PCC and during the natural season for giant

116 ynergy was also observed between the DEP and ragweed in altering the profile of epsilon mRNAs generat

117 h ragweed alone, challenge with both DEP and ragweed induced markedly higher ragweed-specific IgE but

118 In this study, using a ragweed induced mouse asthma model, we studied if BMSCs

119 betaTCR(+)) CD4(+)CD25(+) T cells suppressed ragweed-induced airway hyperresponsiveness and inflammat

120 Adenosine aggravated ragweed-induced allergic lung inflammation.

121 extract enzymatically to analyze its role in ragweed-induced allergy.

122 et (AIT; SCH 39641/MK-3641) for treatment of ragweed-induced AR/C in the first large randomized, doub

123 Adults (n = 784) with short ragweed-induced AR/C were randomly assigned to approxima

124 In a separate inflammatory model (ragweed-induced peritoneal eosinophilia), we demonstrate

125 nflammatory ocular changes associated with a ragweed-induced type-1 hypersensitivity reaction.

126 These ragweed-immunized mice were given ragweed intratracheally on day 11.

127 of international trade have accelerated the ragweed invasion.

128 Ragweed is a major cause of seasonal allergy, affecting

129 se, adults with asthma who were sensitive to ragweed kept daily diaries and recorded peak expiratory

130 ctive was to assess the clinical efficacy of Ragweed MATA MPL (short ragweed pollen allergoid adsorbe

131 evaluate the clinical efficacy and safety of Ragweed MATA MPL compared with placebo by using controll

132 n improvement in total symptom scores in the Ragweed MATA MPL group was statistically significantly g

133 dy demonstrated that an ultrashort course of Ragweed MATA MPL is efficacious in reducing allergy symp

134 In addition, in the presence of ragweed, mouse dendritic cells upregulated their activat

135 n patients with unexplained sensitization to ragweed, mugwort, pellitory, Plantago and plane tree pol

136 ents with sensitization to various extracts (ragweed, mugwort, pellitory, Plantago, and plane tree),

137 o mountain cedar (n = 21), oak (n = 34), and ragweed (n = 23) recorded TSSs during separate out-of-se

138 ae fed soybean to those fed sunflower, giant ragweed, or artificial diet.

139 dust mite, ryegrass, and fungi but not cat, ragweed, or food sources.

140 tic characteristics, efficacy, and safety in ragweed- or birch pollen-induced seasonal allergic rhini

141 significantly reduced after incubation with ragweed (p < 0.001) or cat allergen (p < 0.001) compared

142 Mature pollen grains were collected from ragweed plants grown along main roadsides and in vegetat

143 receptor blocks and a total of 100,938 giant ragweed plants were screened with glyphosate applied at

144 In contrast, challenge with both ragweed plus DEP resulted in decreased expression for Th

145 derstand the effects of chemically processed ragweed pollen (Ambrosia elatior) on the innate immune s

146 This study has shown that in response to ragweed pollen all these cells release inflammatory cyto

147 all minor (Amb a 3, 4, 5, 6, 8 and 9) short ragweed pollen allergen repertoire as well as NADH oxida

148 cross-reactivity might be Amb a 1, the major ragweed pollen allergen, and Art v 6, a highly homologou

149 gest that traffic-related pollution enhances ragweed pollen allergenicity, which may contribute to th

150 clinical efficacy of Ragweed MATA MPL (short ragweed pollen allergoid adsorbed to L-Tyrosine + MPL) v

151 Our quantitative estimates indicate that ragweed pollen allergy will become a common health probl

152 molecule for diagnosis and immunotherapy of ragweed pollen allergy.

153 measured mass spectra from materials such as ragweed pollen and road dust that are likely to form a b

154 PCC and during the natural season for giant ragweed pollen are highly correlated.

155 Various components of ragweed pollen are thought to play a role in the develop

156 elated with spatial and temporal patterns of ragweed pollen concentrations, which are fully independe

157 Hosts sensitized cutaneously with short ragweed pollen developed cutaneous immediate hypersensit

158 PL compared with placebo by using controlled ragweed pollen exposure in an EEC.

159 After cellular oxidative insult induced by ragweed pollen extract (RWE) exposure, we have identifie

160 We recently reported that ragweed pollen extract (RWPE) requires Toll-like recepto

161 Upon Th2 priming of murine B cells, ragweed pollen extract caused a dose-dependent increase

162 challenge with Amb a 1, the major antigen in ragweed pollen extract that does not possess NADPH oxida

163 Instillation of ragweed pollen extract, but not of the major allergen or

164 Aqueous ragweed pollen extract, the low molecular weight fractio

165 days under Th2-like conditions with aqueous ragweed pollen extracts (Amb-APE) or its constituents.

166 Ragweed pollen grains release subpollen particles (SPP)

167 these participants were challenged to short ragweed pollen in a PCC for 3 hours per day for up to 4

168 entify critical factors for allergenicity of ragweed pollen in a physiological model of allergic airw

169 ergic rhinoconjunctivitis symptoms caused by ragweed pollen in an environmental exposure chamber (EEC

170 symptomatology after exposure to VLO, MC, or ragweed pollen in the PCC.

171 A second model simulated current and future ragweed pollen levels.

172 eated with daily birch pollen, grass pollen, ragweed pollen or house dust mite AIT in tablet form wer

173 climate change, have been shown to increase ragweed pollen production, but their effects on pollen a

174 Ragweed pollen proteins were submitted to high-resolutio

175 en source planted in the center and GS giant ragweed pollen receptors surrounding the center in eight

176 Ragweed pollen represents a major allergy risk factor.

177 r MS sequencing of the protein combined with ragweed pollen RNA sequencing.

178 a significant increase in the length of the ragweed pollen season by as much as 13-27 d at latitudes

179 served in ragweed-allergic asthmatics during ragweed pollen season compared with PBMC obtained before

180 o 16 weeks before and through the end of the ragweed pollen season.

181 that besides transporting the vaccine cargo, ragweed pollen shells have additional immunomodulatory p

182 ted in a concentric design with the GR giant ragweed pollen source planted in the center and GS giant

183 e sensitized by topical application of short ragweed pollen to the nasal mucosa followed by a challen

184 OT fractions as novel allergens of the short ragweed pollen, as previously described.

185 imental Ag, OVA, or a common allergen, short ragweed pollen, induced no or minimal immune responses t

186 include respiratory allergens from birch and ragweed pollen, midge larvae, and horse dander; food all

187 protein extract (APE) using sera from short ragweed pollen-sensitized patients.

188 without conjunctivitis (AR/C) on exposure to ragweed pollen.

189 topically for 7 consecutive days with short ragweed pollen.

190 imaging revealed that macrophages can engulf ragweed pollen.

191 otease Amb a 11 as a new major allergen from ragweed pollen.

192 ate the presence of undescribed allergens in ragweed pollen.

193 trial of a vaccine consisting of Amb a 1, a ragweed-pollen antigen, conjugated to a phosphorothioate

194 en-derived adenosine is a critical factor in ragweed-pollen-induced allergic airway inflammation.

195 Ragweed pollens did not cause significant cell membrane

196 Ragweed pollens were also found in the subepithelial reg

197 the most prevalent allergies (e.g. grass and ragweed pollens, dust mites, and cat) and those that ind

198 symptom score [TSS]) during the VLO, MC, and ragweed pollinating seasons and during 2 consecutive PCC

199 n cedar (MC)-positive, 8 MC-negative, and 26 ragweed-positive participants recorded AR symptoms (tota

200 0.34, 0.54, and 0.65 for VLO(+), MC(+), and ragweed-positive participants, respectively).

201 will increase in countries with an existing ragweed problem (e.g., Hungary, the Balkans), but the gr

202 Mice were sensitized with ragweed (RW) and PCF (RW/PCF), PCF alone, or RW alone an

203 ts of IFN-gamma-inducing factor (IL-18) in a ragweed (RW) mouse model of allergic asthma.

204 Ascaris suum (A. suum) eggs concurrent with ragweed (RW) sensitization (RW/acute) or by repeated ino

205 tions starting in 1950 accurately reproduced ragweed's current distribution, including the presence o

206 process-based model estimated the change in ragweed's range under climate change.

207 cant change in IgE antibody titer during the ragweed season (P=0.19).

208 acebo (n = 136) subcutaneously just prior to ragweed season and repeated during the pollen season eve

209 the AIC or placebo vaccine before the first ragweed season and were monitored during the next two ra

210 ymptoms for 15 days during the natural giant ragweed season in San Antonio, Texas.

211 During peak ragweed season, ragweed AIT of 1.5, 6, and 12 Amb a 1-U

212 During the first ragweed season, the AIC group had better peak-season rhi

213 of AIC were again observed in the subsequent ragweed season, with improvements over placebo in peak-s

214 y symptom/medication score (TCS) during peak ragweed season.

215 uce symptoms of allergic rhinitis during the ragweed season.

216 compared with PBMC obtained before and after ragweed season.

217 eason and were monitored during the next two ragweed seasons.

218 Thirty-one ragweed-sensitive participants recorded symptoms for 15

219 We collected nasal lavages from ragweed sensitized subjects at different times after nas

220 antly increased in the blood of serum IgE(+) ragweed-sensitized (RS) compared with serum IgE-nonatopi

221 an isolated, superfused tracheal segment of ragweed-sensitized dogs.

222 Interestingly, ragweed-sensitized patients also displayed an IgG respon

223 hy grass SLIT-tablet trials (n = 3094) and 2 ragweed SLIT-tablet trials (n = 658) and during the last

224 In grass and ragweed SLIT-tablet trials, overall improvement in TNSSs

225 cts on nasal symptoms with timothy grass and ragweed SLIT-tablets were nearly as great as with MFNS a

226 These data support that different ragweed species can be considered an allergen homology g

227 Cross-reactivity towards related ragweed species of IgE and treatment-induced IgG(4) has

228 In the United States, several related ragweed species with diverse geographical distribution c

229 highly cross-reactive to epitopes of related ragweed species without any apparent geographical respon

230 were cross-reactive between isoallergens and ragweed species, some even including mugwort.

231 The IgE elevation was not ragweed specific.

232 both DEP and ragweed induced markedly higher ragweed-specific IgE but not total IgE levels or IgE-sec

233 early and late dosages, strikingly decreased ragweed-specific serum IgE, tracheal ring reactivity to

234 terize the proteomes and allergomes of short ragweed SPP and total pollen protein extract (TOT), and

235 Control of ragweed spread may be an important adaptation strategy i

236 Assumptions about the rate at which ragweed spreads throughout Europe had a large influence

237 ular basis of immune responsiveness to short ragweed (SRW) (Ambrosia artemisiifolia) extract, and gro

238 ce were sensitized in the footpad with short ragweed (SRW) allergen and challenged topically for seve

239 and later challenged intranasally with short ragweed (SRW) allergenic extract.

240 naive A/J mice, A/J mice sensitized to short ragweed (SRW) pollen by intraperitoneal injection and th

241 tal allergic conjunctivitis induced by short ragweed (SRW) pollen, typical allergic signs, stimulated

242 phils and eosinophils toward supernatants of ragweed-stimulated bronchial epithelial cells was analyz

243 isolated from the chitin-treated mice showed ragweed-stimulated IFN-gamma production (15 U/ml) and si

244 For ragweed, such forecasts are extremely important as the s

245 /c allergic hosts was analyzed using a short ragweed (SWR) pollen model of allergic conjunctivitis.

246 kroach, dog, Dermatophagoides farinae, short ragweed, timothy grass, and egg.

247 llergen extracts (English plantain, mugwort, ragweed, timothy grass, ash tree, mites, dog, cat, Alter

248 dog, Dermatophagoides farinae (Der F), Short Ragweed, Timothy grass, egg, milk and peanut.

249 nt (GR) to glyphosate-susceptible (GS) giant ragweed under simulated field conditions using glyphosat

250 gens from short and giant (Ambrosia trifida) ragweed using transgenic mice expressing DQ6 (HLA-DQA1*0

251 Ragweed was grown in climate-controlled chambers under n

252 /J mice sensitized and challenged with short ragweed was used to test immunostimulatory DNA sequences

253 Seeds of GS giant ragweed were harvested from the pollen receptor blocks a

254 gy and positive skin prick test responses to ragweed were randomized and received 4 weekly injections

255 to a clinically relevant neo-allergen (i.e., ragweed) were investigated.

256 (house dust, mixed grasses, mixed trees, and ragweed); wheal size was measured at 20 min.

257 ry estimates indicated that sensitization to ragweed will more than double in Europe, from 33 to 77 m

258 halation allergen (cat, mite, orchard grass, ragweed, wormwood, dog, cockroach, Japan cedar).