ライフサイエンスコーパス: ramp

1 cts a robust analysis of metabolic pathways (RAMP).

2 three receptor activity-modifying proteins (RAMPs).

3 ilevers are situated above a circumferential ramp.

4 n coordination of balance throughout gait on ramps.

5 d found expression correlation for GPCRs and RAMPs.

6 osed mechanisms are responsible for dopamine ramps.

7 axial electric field distortion and voltage ramping.

8 ant stress and stress-varying magnetic field ramping.

9 e-step (10 degrees C within a day) or a slow ramping (0.1 degrees C/day for 100 days) temperature inc

10 both receptor activity-modifying protein-1 (RAMP-1) and calcitonin receptor gene (CT-R) expression i

11 We replicated the ramping activation in RLPFC and found it to be remarkabl

12 stimulating MFC D1DR neurons could increase ramping activity among MFC neurons.

13 cues predicting salient events and one with ramping activity anticipating such events.

14 Finally, interval timing and striatal ramping activity are disrupted when the medial frontal c

15 to determine whether and how they modulated ramping activity in the RLPFC: (1) sequence position unc

16 Previously we found that ramping activity in the rostrolateral prefrontal cortex

17 Their ramping activity is highly sensitive to the subjects' co

18 d that MFC D1DR blockade strongly attenuated ramping activity of MFC neurons that correlated with beh

19 ensory responses of the subthalamic nucleus, ramping activity of the subthalamic nucleus, and movemen

20 ular mechanisms could generate sequential or ramping activity patterns that carry timing information.

21 probability, invariant of fear output, while ramping activity reflected both signals with threat prob

22 Furthermore, we found that striatal ramping activity was correlated with and dependent upon

23 No such smooth-ramping activity was observed in DS ensembles as firing

24 re suppressed by familiar stimuli and showed ramping activity when expected stimuli were omitted from

25 value maximum and displaying goal cell-like ramping activity when navigating toward it.

26 surement to production and was followed by a ramping activity whose slope encoded the previously meas

27 iverse set of important external events (via ramping activity) and to rapidly deploy cognitive resour

28 (MFC) impairs interval timing and attenuates ramping activity, a key form of temporal processing in t

29 neural activity, including neural sequences, ramping activity, and complex spatiotemporal dynamics.

30 Network models can produce persistent and ramping activity, but the positive feedback that is crit

31 First, "ramping" activity, a monotonic change in neuronal firing

32 -timing tasks and found that time-dependent "ramping" activity, a monotonic increase or decrease in n

33 We benchmark RAMP against traditional FBA on genome-scale metabolic r

34 selectivity and support the hypothesis that RAMPs allosterically modulate CTR peptide affinity.

35 ozone observations only in contrast with the RAMP and a Constant Air Quality Model Performance (CAMP)

36 Here, we performed force-ramp and force-jump experiments, in combination with adv

37 ecorded in the absence of fusimotor input to ramp and hold stretches as well as to sinusoidal vibrati

38 aining additional oligonucleotide-conjugated Ramp and horseradish peroxidase (HRP).

39 ells to characterize the effect of different RAMP and ligand combinations on this pathway.

40 vent composition range covered by the mixing ramp and on the available pressure.

41 POL beta incorporated rAMP and rCMP opposite 7,8-dihydro-8-oxoguanine (8-oxodG

42 h were correlated with both the slope of the ramp and the monkey's corresponding production interval

43 numerous repetitions are needed for gradient ramping and varying diffusion delays.

44 We first tested six different energy ramps and analyzed the fragmentation behavior of cross-l

45 We discovered that RAMPs and GPCRs tend to have orthologs in the same speci

46 ily and identify robust interactions between RAMPs and nearly all chemokine receptors.

47 In humans, there are three RAMPs and over 800 expressed GPCRs, making direct experi

48 individuals during walking on level ground, ramps and stairs.

49 ults suggest global coevolution of GPCRs and RAMPS and support the hypothesis that GPCRs interact glo

50 firing frequencies in response to mechanical ramp-and-hold stimuli.

51 e responses of individual sensory neurons to ramp-and-hold stretches and sinusoidal vibrations before

52 ies of the dynamic peak and dynamic index to ramp-and-hold stretches were significantly higher in the

53 activity in M1 in two behavioral phases of a ramp-and-hold visuomotor adaptation paradigm.

54 as equally apparent when the slow irradiance ramp appeared alone or when a variety of higher-frequenc

55 variability in model performance, our novel RAMP approach is able to extract more information in ter

56 Regionalized Air Quality Model Performance (RAMP) approach to integrate chemical transport model (CT

57 n in the striatum, and explains why dopamine ramps are an effective signal to occupy dopamine recepto

58 These ramps are commonly assumed to reflect the gradual accumu

59 Receptor-activity-modifying proteins (RAMPs) are single transmembrane-spanning proteins which

60 Receptor activity-modifying proteins (RAMPs) are widely expressed in human tissues and, in som

61 faulting and compressional strike-slip relay ramps, as well as second-order R shears, R' and P shears

62 rcuit trials involving level-ground walking, ramp ascent and descent, and stair ascent and descent.

63 Thus, RAMP association with chemokine receptor family members

64 The RAMPs augment the binding site with distinct contacts to

65 with a marked sign-reversal of Cotton effect ramping between Deltaepsilon = +35 M(-1) cm(-1) for [P-1

66 ampling and to enable controlled temperature ramps beyond the present upper limit of about 415 degree

67 onwards, with full ventilation of the outer ramp by ~542 Ma.

68 as the stochastic elements dissipate, and C) RAMP can identify biologically tolerable diversity of a

69 Enabling ramping capability for NPPs would raise the limit of PV

70 ase-load nuclear power plants (NPPs) without ramping capability in the region limits PV integration l

71 We also uncover evidence of ramping cell activity in humans, which represents a comp

72 ng the population bursts of CA3-CA1 neurons (ramping cells).

73 ferred conformation of peptides that require RAMPs; CGRP, AM, and amylin.

74 ensity-step changes (clouds and shadows) and ramp changes (sunrise), respectively.

75 nist-promoted G protein coupling to each CLR.RAMP complex.

76 t-solubilized fluorescent protein-tagged CLR.RAMP complexes expressed in mammalian cells.

77 How peptides selectively bind GPCR:RAMP complexes is unknown.

78 nd may inform drug development targeting CLR:RAMP complexes.

79 ng time encoding as we find that the linear "ramping" component of each neuron's firing rate strongly

80 Using a pulsed power generator, we ramp compress spherical gold nanoparticle arrays to pres

81 Our dynamic magnetic ramp compression approach produces smooth, shockless (th

82 pproach applies magnetically driven uniaxial ramp compression to mimic established embossing and impr

83 Here we describe ramp-compression measurements for diamond, achieving 3.7

84 RAMP consists of coexpressing in cultured cells (i) an o

85 is, human subjects performed slow triangular ramp contractions of the ankle dorsiflexors in the absen

86 ed the myoelectric activity during isometric ramp contractions to the target forces of 35%, 50% and 7

87 pied receptors revealed that both ligand and RAMP control mG(s) coupling and defined how agonist enga

88 By combining the most successful energy ramps, cross-link yield can be increased by up to 40%.

89 The glycan effect extended to RAMP-CTR amylin receptor complexes and was also conserve

90 ar frequency-current responses to triangular ramp current injections.

91 BPA increased Na(v)-mediated ramp currents elicited with slow depolarizations.

92 The mutation increases ramp currents in response to slow depolarizations.

93 ession and biophysical properties other than ramp currents of Na(v) channels, were unchanged by BPA.

94 ered threshold channels because they produce ramp currents, amplifying small depolarizations and enha

95 n more than it did the output of a standard (ramping) decision-making model, and provided a robust pr

96 amily of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai

97 results reveal unexpected differences in how RAMPs determine CTR and CLR peptide selectivity and supp

98 Our results demonstrate that ramping dopamine signals are consistent with RPEs rather

99 Ramping dopamine signals can be driven by a dynamic stim

100 nal understanding of rapid phasic and slowly ramping dopamine signals: dopamine neurons perform a der

101 unknown what computations may underlie this ramping dynamic.

102 cribed by discrete "stepping" or continuous "ramping" dynamics.

103 ent features (such as codon usage and the 5' ramp effect) in determining the accuracy of predictions.

104 urons were better described by stepping than ramping, even when conditioned on evidence or choice.

105 most of the observed effects in temperature-ramp experiments are due to entropic effects (fitting wi

106 he problem of relating force-clamp and force-ramp experiments, and identify a linker and loading rate

107 n of rupture forces in force-clamp and force-ramp experiments, respectively.

108 QCM temperature ramping experiments identified domains of different phas

109 e shifting, known from isothermal and normal ramped fast-GC systems, are overcome.

110 At the single-neuron level, these included ramping firing rates and cycle-specific responses.

111 A ramp/flat fault plane can introduce an anticline with be

112 A compressive force introduced by a ramp/flat fault was suggested as its origin of formation

113 tion with ICAM-1 mainly corresponds to force ramps followed by sudden jumps.

114 reversible association with motor proteins (RAMP), for manipulation of organelle positioning within

115 simple force protocols, such as constant or ramped forces.

116 d-particles were then subjected to a heating-ramp from 22 to 44 degrees C.

117 e, which is set by reversing the temperature ramp from heating to cooling during the MIT.

118 litude of the cA(4) signal, providing an off ramp from the programmed cell death pathway in cells tha

119 properties were characterized by Temperature-Ramp FTIR, DSC & CMC measurements.

120 The method takes advantage of a nonlinear pH ramp generated by the urea-urease clock reaction.

121 ncovered novel RAMP-GPCR interactions, human RAMP-GPCR disease-causing mutations, and RAMP-related hu

122 In addition, the resulting RAMP-GPCR interaction map suggests that RAMP1 and RAMP3

123 However, whether RAMP-GPCR interactions are widespread, and the nature of

124 Resurging interest in identifying RAMP-GPCR interactions has recently been fueled by coevo

125 highlight recent papers that uncovered novel RAMP-GPCR interactions, human RAMP-GPCR disease-causing

126 ng and molecular dynamics simulations of the RAMP-GPCR-G protein complexes.

127 Moreover, RAMP has the properties that: A) metabolic states are (L

128 Although RAMPs have been previously studied in the context of the

129 Such previously unrecognized functions of RAMPs highlight the need to consider all receptor-intera

130 Hemodynamic ramp (HR) tests can guide the optimization of left ventr

131 ocedure involving the metalation of the SAMP/RAMP hydrazones of N-Boc-azetidin-3-one, reaction with a

132 Reduced fast ice after 2006 ramped iceberg scouring, killing half the encrusting ben

133 These can be avoided by using Single-Point Ramped Imaging with T (1) enhancement (SPRITE).

134 Particle-in-cell simulations show that a ramp in a plasma density profile can affect the evolutio

135 rrelated to taste palatability, the apparent ramp in stimulus-aligned choice-related firing was shown

136 in the measurement epoch to the slope of the ramp in the production epoch.

137 e of state transitions consistently elicited ramping in the RLPFC, regardless of the level of the dec

138 previous sequential task potentially engaged ramping in the RLPFC.

139 However, the ramping in trial-averaged responses could instead arise

140 hypothesis that GPCRs interact globally with RAMPs in cellular signaling pathways.

141 ected at six different cloverleaf freeway on-ramps in Southern Michigan, using 2D images from scannin

142 Finally, we developed an in-source CID ramping (InCIDR) method to analyze the intensity changes

143 Receptor activity-modifying proteins (RAMPs) interact with G-protein-coupled receptors (GPCRs)

144 e new studies reveal previously unrecognized RAMP-interacting GPCRs, many of which expand beyond Clas

145 Most notably, we identify robust RAMP interaction with atypical chemokine receptors (ACKR

146 The results are discussed in the context of RAMP interactions probed through molecular modeling and

147 on approaches, we comprehensively screen for RAMP interactions within the chemokine receptor family a

148 These different CLR-RAMP interactions yield discrete receptor pharmacology a

149 s, the traditional ages where people find on-ramps into science, technology, engineering, and mathema

150 PFG NMR associated with a sigmoid gradient ramp is an exciting strategy to study drugs as a whole,

151 y of anoxic incursions onto the inner to mid-ramp is recorded from ~547 Ma onwards, with full ventila

152 istent with RPEs rather than value, and this ramping is observed at all stages examined.

153 ample between two diamond anvils and using a ramped laser pulse to slowly compress the sample, while

154 ystalline optical potential is also linearly ramped, light can undergo periodic Bloch oscillations, a

155 rafish, receptor activity modifying protein (RAMP)-like triterpene glycoside receptor (RL-TGR), was p

156 5 minute blocks of high-reward trials led to ramp-like decreases in mean local blood volume; these re

157 mean local blood volume; these reversed with ramp-like increases during low reward.

158 However, recent reports of ramp-like increases in dopamine concentration in the str

159 d either of a hyperpolarization, an extended ramp-like shoulder, or a depolarization reminiscent of d

160 T cells encountering the ramp-like structures exhibited MLC accumulation near hea

161 In this study, we fabricated ramp-like structures with a 5 mum height and various slo

162 tion near head-tail junctions contacting the ramp-like structures, and made turns to the direction pe

163 probability of T cells climbing sharp-edged ramp-like structures, indicating intriguing turning beha

164 ing turning behavior of T cells climbing the ramp-like structures.

165 slopes, and observed T cells climbing up the ramp-like structures.

166 turns to the direction perpendicular to the ramp-like structures.

167 Collectively, these suggest that dopamine ramps may be explained, with only minor disturbance, by

168 lem shows that FBA is a limiting case of our RAMP method.

169 G(s)) yielded a mobility-shifted agonist.CLR.RAMP.mG(s) quaternary complex gel band that was sensitiv

170 Second, we extended the ramping model to include a non-zero baseline and compres

171 How the three agonists and RAMPs modulate CLR binding to transducer proteins remain

172 constructions of native type III Cmr (CRISPR RAMP module) complexes in the absence and presence of ta

173 crete multipoint steady-state and continuous ramped-multipoint data acquisition methods.

174 Third, striatal ramping neurons are correlated with activity of the medi

175 In contrast, ramping neurons predict the timing of many salient, nove

176 -1 nm per cycle, generating a "zigzag" force ramp of alternating positive and negative loading rates.

177 SA-like sheath field in the downward density ramp of the target, leading to an overall broad spectrum

178 ethanol induced an initial startle and slow ramping of group activity, whereas high doses of ethanol

179 mulation of terminals modulated time-related ramping of medium spiny neurons in the striatum.

180 initiate synthesis of l-N(3) via the thermal ramping of the sample in temperature range 3.5 to 20 K.

181 aluminum jacket design for rapid temperature ramping of xenon-rich gas mixtures (up to 2 atm partial

182 Wide-field imaging revealed widespread ramps of Ca(2+) activity during the accumulation and vis

183 resulting from zero-crossing magnetic field ramps of various durations, amplitudes, and step sizes.

184 was achieved through catalysis, by the free Ramp, of a restriction cascade containing additional oli

185 d on: (i) hybridization of a target DNA to a Ramp-oligonucleotide probe conjugate, followed by (ii) s

186 ding the molecular details of the effects of RAMPs on CLR.

187 al current-clamp recordings using excitatory ramp or square-step current injections failed to reveal

188 , high outlier (worse than expected), or non-RAMP outlier using standard observed-to-expected methodo

189 lateral prefrontal cortex (RLPFC) activation ramped over sequence position and reset at the initiatio

190 The trabeculae were subjected to shortening ramps over a range of velocities and the extent of RLC p

191 was either provided after each trial of the ramp phase of adaptation when a gradual increase in the

192 rce and motor unit discharge rate during the ramp-phase of the contractions was also not altered by t

193 ndon, where we showed that BiP expression is ramped preemptively prior to a surge in collagen synthes

194 ((2)D) atom was observed during the thermal ramping process.

195 bonding mechanism that manifests under force ramp protocols.

196 ns allow us to analyze force-clamp and force-ramp pulling experiments.

197 This new strategy employs a ramped pulse shape, where the maximum amplitude is achie

198 Ramped pyrolysis profiles indicate that the organic mate

199 while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the tri

200 this requires the reference standard method (RAMP(R) immunoassay)) or alternatively on the basis of t

201 TIMS conditions, including voltage ramp, ramp time, and accumulation time were optimized fo

202 is protonated on the adenines of every other rAMP-rAMP helix base pair.

203 ure variation (4 <-> 50 degrees C) at a fast ramp rate (25 degrees C min(-1) ).

204 he generator's net efficiency, capacity, and ramp rate.

205 egardless of the strain rate and temperature ramping rate.

206 on in apparent RACiR slopes under high CO(2) ramp rates.

207 man RAMP-GPCR disease-causing mutations, and RAMP-related human pathologies, paving the way for a new

208 The amount of Ramp released into solution upon cleavage was proportion

209 The characteristics of this ramp-reversal memory effect do not coincide with any pre

210 Two mutant REases for amplification (Ramp), S17C BamHI and K249C EcoRI, were conjugated to ol

211 to the gradual slope of the circumferential ramp, self-organizes around tip-gated microcantilevers t

212 Temperature-ramped separations of a simple alkane mixture using the

213 Within genes, the ramp sequence assists in ribosome spacing and decreases

214 Using the strictest ramp sequence cut-off, we show that across most taxonomi

215 ecies, no previous attempt at extracting the ramp sequence from specific genes has been published.

216 We validate the existence of a ramp sequence in most species by running ExtRamp on 229

217 cy and enable identification of genes with a ramp sequence.

218 , we show that across most taxonomic groups, ramp sequences are approximately 20-40 codons long and o

219 mp, a software package that quickly extracts ramp sequences from any species using the tRNA adaptatio

220 We evaluate differences in reported ramp sequences when we use different parameters.

221 ntical codon pairing, co-tRNA codon pairing, ramp sequences, and nucleotide composition in 17,634 gen

222 increases, a higher proportion of genes have ramp sequences.

223 acterised all water depths in inner to outer ramp settings from ~550 to 547 Ma, when the first skelet

224 recorded single group IV fibre activity to a ramp-shaped mechanical stimulation.

225 agnitude of ktr following step shortening or ramp shortening.

226 , we explore three possible accounts of such ramping signals: (a) the resolution of uncertainty about

227 including buffer ionic strength and thermal ramping speed as these parameters both influence the lig

228 ntal cortex (RLPFC) exhibits activation that ramps steadily through the sequence and is necessary for

229 Furthermore, voltage-ramp stimulation proved useful.

230 ranging from ocular tracking of radial step-ramp stimuli, to eccentric gaze holding, to pupillary re

231 ns, with strain increments from 5% to 50%, a ramp-strain rate of 2% per second, and relaxation period

232 readmission during the 1 year following the ramp study (total of 18 events; hazards ratio, 1.09; 95%

233 One-year survival after the ramp study was comparable in both groups (89% versus 88%

234 pathologies, paving the way for a new era of RAMP-targeted drug development.

235 econstruction microscopy (dSTORM) with phase ramp technology.

236 illary, interface, injection volume, voltage ramp, temperature, capillary conditioning, and rinsing p

237 constant were expressed relative to maximal ramp test power, no sex difference was observed.

238 patients undergoing an invasive hemodynamic ramp test were prospectively enrolled and followed for 1

239 LVAD speed was optimized using a ramp test, targeting the following goals: central venous

240 ghlighted through the rheometric temperature ramp test.

241 nts (median 61 years old, 53 male) underwent ramp testing 236 days after LVAD implantation, and 54 (6

242 re, normalization of decoupling (n=8) during ramp testing was significantly associated with higher 1-

243 al and heart failure readmission rates after ramp testing were assessed.

244 LVADs underwent routine invasive hemodynamic ramp testing with right heart catheterization, during wh

245 er adjustment of their rotation speed during ramp testing, 30 patients (48%) had inappropriate decoup

246 iesel particle filter (DPF), driven on speed ramp tests and transient cycles.

247 the presence of dissociation points or "exit ramps" that naturally would terminate sliding.

248 cation of the individual oligomers by slowly ramping the probe temperature and collecting data-depend

249 locity traveling-wave ion mobility settings, ramping the traveling-wave velocity increased drift spac

250 ases in recently fixed carbon during thermal ramping, thereby maintaining overall increases in isopre

251 TIMS conditions, including voltage ramp, ramp time, and accumulation time were optimized for each

252 s bearing females were exposed to a 5 h heat ramp to peak temperatures of 34.1-38.0 degrees C crossed

253 (e.g., 37 and 615 Hz) superimposed onto a dc ramp to quantify the close-to-reversible Fc(0/+) process

254 p from the surface and the probe temperature ramped to liberate the sampled materials into the gas ph

255 s study further highlights the importance of RAMPs to CLR pharmacology and to bias in general, as wel

256 Tethering RAMPs to CTR enhanced binding of rAmy, CGRP, and the AMY

257 We find evidence consistent with a ramp-to-threshold mechanism, in which increasing neurona

258 firing on one of two timescales: at onset or ramping toward shock delivery.

259 Neurons in LIP exhibit ramping trial-averaged responses during decision-making.

260 ea, a face-space coding model with sigmoidal ramp tuning provided a better account of the data than o

261 COVID-19, establishing contingency plans to ramp up in case of another surge, while returning to bus

262 or for Africa and the WHO Executive Board to ramp up routine immunization (RI) activities, began to i

263 With this strategy, they first ramp up safety margins by squeezing before relaxing thei

264 ploying a GC column and detector temperature ramp up to 220 degrees C.

265 reasing over time as deployment continues to ramp up.

266 ine concentration changes were detected that ramped up as rats executed each action sequence and decl

267 Non-Chinese primary production ramped up at a speed of 4% of total market volume per ye

268 e concurrently with shape classification but ramped up more gradually, and the slope of the classific

269 Cognitive scientists have ramped up online testing in response to the COVID-19 pan

270 Postsaccadic information ramped up rapidly after saccade offset.

271 in the bilayer of the cubic mesophase can be ramped up stepwise from less than a milligram per millil

272 Here, we estimate impacts of ramping up and accelerating baloxavir treatment on popul

273 Furthermore, ramping up and rapid loss of activity were closely assoc

274 initiation of PVT was elicited by gradually ramping up I(Ca,L) to simulate the initial phase of a sy

275 While it is known that ramping up laser pump power increases the amplitude of s

276 was manifested in the beta-band (12-30 Hz), ramping up slowly over 500 ms after stimulus onset and p

277 By contrast, dopamine release ramps up as animals approach rewards, mirroring reward e

278 During induction, a 7-day prephase/dose ramp-up (days -6 to 0) was followed by an additional 7 d

279 cycle 1 [28-day cycles], with a 5-week dose ramp-up [20 mg, 50 mg, 100 mg, and 200 mg, then 400 mg d

280 e than the ones revealed through traditional ramp-up approaches.See related article by Finn et al., p

281 patients were treated with a weekly stepwise ramp-up in doses as high as 400 mg per day.

282 Recordings also revealed a ramp-up in the number of neocortical slow oscillations p

283 ), we projected the impacts of a countrywide ramp-up of transfusion therapy.

284 starting at 20 mg per day with stepwise dose ramp-up over 5 weeks to 400 mg per day.

285 Treatment commenced with a 3-week dose ramp-up period for most patients in dose-escalation coho

286 Furthermore, L2/3 acquired a ramp-up response temporal profile, potentially encoding

287 ted once daily venetoclax with a weekly dose ramp-up schedule (20, 50, 100, 200, 400 mg) over 4-5 wee

288 A gene-activation or gene-specific ramp-up strategy would be generally helpful if such coul

289 taT(RT) = 12 degrees C to 40 degrees C) with ramp-up times of a minute.

290 w range of achievable temperatures, and long ramp-up times.

291 were not identified using the conventional "ramp-up" approach in previous studies that employed the

292 t-of-field firing of CA1 place cells, with a ramping-up of firing rate during the waiting period, but

293 IP) area exhibit firing rates that appear to ramp upward or downward during decision-making.

294 It is unclear whether RAMPs use a similar mechanism to modulate CTR affinity f

295 information available from slow temperature ramps versus ballistic temperature jumps is presented.

296 loss, CUE, and MBC were greater in the slow (ramp) warming treatment.

297 The furnace temperature ramp was set at a rate of 5 degrees C min(-1) with 10 mi

298 Discrete 15 s heating ramps were generated, creating a thermal desorption prof

299 ll described by either stepping or nonlinear ramping, which may be less categorically distinct than t

300 ffects on Family B GPCRs, the coevolution of RAMPs with many GPCR families suggests an expanded reper