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1                                Patients were randomised 1:1 to high dose (HD) IIV followed by standar
2 izumab during the upload phase and were then randomised 1:1 to receive either the same dosage of rani
3                                Patients were randomised 1:1 to receive subcutaneous placebo or galcan
4              Patients receiving insulin were randomised 1:1:1:1 to placebo or dapagliflozin at 2.5, 5
5                                Patients were randomised 1:2 (standard of care:dabigatran) and stratif
6       We did an open-label, non-inferiority, randomised (1:1 with blocks of six), multicentre, phase
7 nant women from Uganda and South Africa were randomised (1:1) to daily dolutegravir (50 mg) or efavir
8 sk category and type of previous therapy and randomised (1:1) with a complete permuted block design (
9 er randomised trial in which 75 schools were randomised (1:1:1) to receive the SEHER intervention del
10                            In April 2015, we randomised 80 practices to Trial 1 (40 per arm) and 64 t
11                      None of the trials were randomised and none of the individuals involved were mas
12                            242 patients were randomised and received >=1 dose of trial medication (la
13  is below 15 cm from the anal verge, will be randomised between either a TAMIS or an ESD procedure.
14                                      In this randomised, blinded, parallel-group, pragmatic equivalen
15         In "Completely randomized" (CR) and "Randomised block" (RB) experimental designs, both the as
16  research use "Completely randomised" (CR), "Randomised block" (RB), or one of the more specialised n
17  SD = 8; M BMI = 34.48 kg/m2, SD = 4.87) and randomised by a blinded researcher.
18                         In the double-blind, randomised CAPP2 trial, 861 patients from 43 internation
19 ood Assessment Chart score; <=2 vs >=3), and randomising centre.
20 n=534), ten of whom were enrolled in the non-randomised ChAdOx1 nCoV-19 prime-boost group.
21 th obesity (BMI >= 30 kg/m(2)) enrolled in a randomised clinical trial (Gut Bugs Trial), to identify
22                        We did an open-label, randomised clinical trial at 57 centres in Brazil.
23 RV306 is a double-blind, placebo-controlled, randomised clinical trial done at three clinical sites i
24                             We did the first randomised clinical trial in the USA of extracorporeal m
25                                There were no randomised clinical trials nor studies comparing outcome
26 y registered with the International Standard Randomised Clinical Trials Number, ISRCTN79151659.
27   Despite being internationally recommended, randomised clinical trials of ACP in patients with advan
28 ek 96 were 205 cells per muL (SD 191) in the randomised cohort and 119 cells per muL (202) in the non
29                 12 (4%) of 272 people in the randomised cohort and 17 (17%) of 99 in the non-randomis
30 eated, of which 272 participants were in the randomised cohort and 99 in the non-randomised cohort.
31 domised cohort and 17 (17%) of 99 in the non-randomised cohort died; the median baseline CD4 count fo
32 fficacy of fostemsavir versus placebo in the randomised cohort of the BRIGHTE study after 8-day funct
33                    Response rates in the non-randomised cohort were 37% (37 of 99) at week 24 and wee
34 lus optimised background therapy; or the non-randomised cohort, in which patients with no remaining a
35 A >=400 copies per mL) into two cohorts: the randomised cohort, in which patients with one or two ful
36                                       In the randomised cohort, rates of virological suppression (HIV
37 e in the randomised cohort and 99 in the non-randomised cohort.
38 ohort and 119 cells per muL (202) in the non-randomised cohort.
39 m 0.20 at baseline to 0.44 at week 96 in the randomised cohort.
40          We implemented a multi-arm, cluster-randomised community effectiveness trial in three rural
41 echniques are standard of care, but a direct randomised comparison is lacking.
42  included randomised control trials, cluster randomised control trials and quasi-randomised control t
43  cluster randomised control trials and quasi-randomised control trials comparing digital or blended e
44                                  We included randomised control trials, cluster randomised control tr
45  METHODS/DESIGN: Multicenter non-inferiority randomised controlled clinical trial.
46 frequencies are experimentally determined in randomised controlled clinical trials.
47                           The studies used a randomised controlled experimental design, with embedded
48                                            A randomised controlled non-blinded eight-arm crossover st
49         We conducted a stepped-wedge cluster-randomised controlled trial (RCT) comparing CQI to usual
50 Better Eating and Activity Trial (UPBEAT), a randomised controlled trial (RCT), of a lifestyle interv
51                   In a future, fully powered randomised controlled trial (RCT), retention could be im
52    In this multicentre, open-label, phase 3, randomised controlled trial (the ENDURANCE trial; E1A11)
53       Twenty-six studies, which included one randomised controlled trial and 25 observational studies
54 the techniques, and results from the ongoing randomised controlled trial are need to confirm these re
55             Investigators did an open-label, randomised controlled trial at three HIV treatment sites
56                   This is the first European randomised controlled trial comparing the effectiveness
57 ed including nonconventional alternatives to randomised controlled trial designs.
58 R was a pragmatic, superiority, multicentre, randomised controlled trial done at 39 hospitals in the
59 driven extension follow-up of a multicentre, randomised controlled trial done in 85 hospitals across
60                                     We did a randomised controlled trial enrolling patients with at l
61 id a multicentre, pragmatic, parallel-group, randomised controlled trial in 12 hospitals and four pri
62       We did an open-label, non-inferiority, randomised controlled trial in a public clinic in Durban
63         We conducted a stepped-wedge cluster-randomised controlled trial in Eswatini to determine the
64            We did a phase 1/2, single-blind, randomised controlled trial in five trial sites in the U
65                                            A randomised controlled trial in Papua, Indonesia, compari
66  cross-sectional data collected as part of a randomised controlled trial in private for-profit dispen
67               We report the pilot phase of a randomised controlled trial in routine screen-and-treat
68 ered the trial on the International Standard Randomised Controlled Trial Number (ISRCTN) (Number: 377
69 ers.TRIAL REGISTRATIONInternational Standard Randomised Controlled Trial Number (ISRCTN) Registry, IS
70   We did an open-label, pragmatic, adaptive, randomised controlled trial of adding oseltamivir to usu
71 community-based survey followed by a cluster randomised controlled trial of people with hypertension
72          This double-blind, sham-controlled, randomised controlled trial provides class I evidence of
73             This open label, parallel group, randomised controlled trial recruited children and young
74                       We conducted a cluster randomised controlled trial to assess the effectiveness
75       SPRINT was an open-label, multicentre, randomised controlled trial undertaken at 102 sites, inc
76 his multicentre, double-blind, parallel-arm, randomised controlled trial was done at 13 specialist cl
77                               An open-label, randomised controlled trial was done at 19 hospitals and
78                         Our two-arm, cluster-randomised controlled trial was done in sex-work venues
79 sh (randomly selected from participants in a randomised controlled trial), on income, food security,
80                       In this 2-year cluster-randomised controlled trial, 594 community clusters in N
81                          In this open-label, randomised controlled trial, adults (aged 16-55 years) w
82 S is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978.
83         In this multicentre, parallel group, randomised controlled trial, we recruited infants withou
84 ulticentre, double-blind, response-adaptive, randomised controlled trial, we recruited patients from
85 g the use of a placebo control in a surgical randomised controlled trial.
86  the design of a multicenter non-inferiority randomised controlled trial.
87 dual participant data from 14 of 20 eligible randomised controlled trials (8278 [79%] of 10 431 parti
88                                       Across randomised controlled trials (k=40) and observational tr
89 ss, PsycINFO, and Science Citation Index for randomised controlled trials (RCTs) and non-RCTs of psyc
90 ial registry platforms on July 15, 2018, for randomised controlled trials (RCTs) and observational st
91                   We systematically reviewed randomised controlled trials (RCTs) comparing PARP inhib
92 to prospectively plan a systematic review of randomised controlled trials (RCTs) comparing these radi
93                                      Several randomised controlled trials (RCTs) have assessed if ind
94                                     However, randomised controlled trials (RCTs) investigating the im
95 are increasingly considered for inclusion in randomised controlled trials (RCTs) involving patients w
96 spects, are increasingly evaluated in cancer randomised controlled trials (RCTs) to provide informati
97 observational prospective studies (OPSs) and randomised controlled trials (RCTs) were included.
98                    We enrolled double-blind, randomised controlled trials (RCTs).
99  were included in the analysis, including 30 randomised controlled trials and 12 cohort studies.
100                                              Randomised controlled trials are considered the gold sta
101                                 Double-blind randomised controlled trials comparing clozapine with ot
102 EDLINE, Embase, and The Cochrane Library for randomised controlled trials comparing parenteral antico
103 individual participant data meta-analysis of randomised controlled trials examines the effect of hepa
104 non-pregnant adults, few published data from randomised controlled trials have compared the safety an
105                                         Four randomised controlled trials have tested the efficacy of
106 terventions for Pre-eclampsia (CLIP) cluster randomised controlled trials in Mozambique, Pakistan, an
107 stenosis is consistent with the two previous randomised controlled trials in younger cohorts, support
108                                  We included randomised controlled trials of cardiovascular outcomes
109 nstruction should ideally be investigated by randomised controlled trials of pragmatic design.
110      Use of placebo controls is justified in randomised controlled trials of surgical interventions p
111  we used data from three previously reported randomised controlled trials to estimate lifetime gains
112      These findings highlight the need to do randomised controlled trials to test higher transfusion
113 d immunotherapy which should be evaluated in randomised controlled trials.
114 to optimise the design and implementation of randomised controlled trials.
115 vational cohort and case-control studies and randomised controlled trials.
116                             We did a cluster-randomised controlled, open-label trial using a two-by-t
117                            This multicentre, randomised, controlled cross-over trial was designed to
118 AN is an ongoing, open-label, sponsor-blind, randomised, controlled phase 3 trial at 209 cancer treat
119                                     We did a randomised, controlled trial involving 23 breast screeni
120       This phase 2, open-label, multicentre, randomised, controlled trial was undertaken at six clini
121 sis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil
122                                         This randomised, controlled, double-blind, multicentre, non-i
123  of the phase 2 component of a single-blind, randomised, controlled, phase 2/3 trial (COV002), health
124                     DANUBE is an open-label, randomised, controlled, phase 3 trial in patients with u
125              This multicentre, double-blind, randomised, controlled, phase 3 trial was done in 130 ac
126                          In this open-label, randomised, controlled, phase 3, three-arm, Gynecologic
127 ucted a hybrid implementation-effectiveness, randomised, controlled, unblinded, parallel-group pilot
128 e empirical networks as well as that of some randomised counterparts, and examine the extent to which
129 ged in pre-clinical research use "Completely randomised" (CR), "Randomised block" (RB), or one of the
130 nd extended feeding (EXF, 15 h day(-1)) in a randomised cross-over design (trial registration: ACTRN1
131 idem or placebo according to a double-blind, randomised, cross-over design.
132 ross two sessions in a double-blinded pseudo-randomised crossover design.
133                    Utilising a double-blind, randomised crossover study design, we recruited 20 healt
134 ributed between patient groups given the non-randomised design of the studies included.
135                                              Randomised designs and controlled observational designs
136 sing fMRI task at least 8 days apart using a randomised double-blind crossover design.
137                                            A randomised double-blinded trial of 3 pyrethroid LLIN pro
138                                  REWIND is a randomised, double-blind placebo-controlled trial at 371
139                    This study is an ongoing, randomised, double-blind, multicentre, active-controlled
140                                         This randomised, double-blind, parallel-group, multicentre pl
141                                   SPI2 was a randomised, double-blind, parallel-group, placebo-contro
142          RESTORE BRAIN was an international, randomised, double-blind, parallel-group, placebo-contro
143                        We did a multicentre, randomised, double-blind, phase 2 study for adult patien
144                                         This randomised, double-blind, phase 3, placebo-controlled, m
145                                  We did this randomised, double-blind, placebo-controlled phase 1 tri
146                             IMspire150 was a randomised, double-blind, placebo-controlled phase 3 stu
147                  We performed a multicentre, randomised, double-blind, placebo-controlled randomised
148                                   The MS-SPI randomised, double-blind, placebo-controlled study found
149                                         This randomised, double-blind, placebo-controlled study was d
150  patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study.
151             We did a multicentre, phase 2/3, randomised, double-blind, placebo-controlled trial at 92
152                                   This was a randomised, double-blind, placebo-controlled trial of vi
153 estinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial.
154                 IBIS-II is an international, randomised, double-blind, placebo-controlled trial.
155                              BE ACTIVE was a randomised, double-blind, placebo-controlled, dose-rangi
156                                     We did a randomised, double-blind, placebo-controlled, event-driv
157                                     We did a randomised, double-blind, placebo-controlled, phase 2 tr
158                            This multicentre, randomised, double-blind, placebo-controlled, phase 3 st
159                                COMBI-AD is a randomised, double-blind, placebo-controlled, phase 3 tr
160                               BROCADE3 was a randomised, double-blind, placebo-controlled, phase 3 tr
161                                     We did a randomised, double-blind, placebo-controlled, trial at 3
162                            Participants were randomised equally to either receive oral rosuvastatin (
163 the form of the Applying Surgical Placebo in Randomised Evaluations (known as ASPIRE) checklist, for
164 tween 1790 and 2012 were grown in replicated randomised field trials for three years, milled, and whi
165  was no difference in adverse events between randomised groups.
166 1,503 (93.4%); follow-up was similar between randomised groups.
167                     The BCPP was a community-randomised HIV-prevention trial done in 30 communities a
168 al-time, dynamic, internet-based, stratified randomised minimisation procedure.
169                                      In this randomised, multicentre, open-label, phase 3 study, 466
170                                ASPIRIN was a randomised, multicountry, double-masked, placebo-control
171                  This was a prospective, non-randomised, non-blinded, consecutive cohort study conduc
172 n stenosis: updated 5-year outcomes from the randomised, non-inferiority NOBLE trial.
173      FAST-Forward is a multicentre, phase 3, randomised, non-inferiority trial done at 97 hospitals (
174                        We did an open-label, randomised, non-inferiority, phase 3 trial in 31 transpl
175 bstudies within the open-label, multicentre, randomised ODYSSEY trial (NCT02259127) of children with
176                                     We did a randomised, open-label trial in eight academic hospitals
177                                This phase 3, randomised, open-label trial was done at 123 sites in 21
178                                      In this randomised, open-label trial, DolPHIN-2, we recruited pr
179                        We did a multicentre, randomised, open-label trial, with blinded outcome asses
180                     CASSIOPEIA is an ongoing randomised, open-label, active-controlled, parallel-grou
181                   ALCYONE was a multicentre, randomised, open-label, active-controlled, phase 3 trial
182                        We did a prospective, randomised, open-label, blinded-endpoint, non-inferiorit
183                                  FeDeriCa, a randomised, open-label, international, multicentre, non-
184                                   This was a randomised, open-label, multicentre, phase 3 trial done
185                             The prospective, randomised, open-label, non-inferiority NOBLE trial was
186                                         This randomised, open-label, non-inferiority phase 3 trial, w
187 Oncology Group and NRG Oncology multicentre, randomised, open-label, phase 2 trial, we enrolled eligi
188                              In the ongoing, randomised, open-label, phase 3 KEYNOTE-426 study, adult
189           We report the 5-year results for a randomised, open-label, phase 3 study (RESPONSE) that en
190                      CLL14 is a multicentre, randomised, open-label, phase 3 trial done at 196 sites
191                         The LACC trial was a randomised, open-label, phase 3, non-inferiority trial d
192  PubMed and Embase between 1970 and 2019 for randomised or otherwise controlled studies and observati
193 grees C and core heating by 1.5 degrees C in randomised order at sea level; acute hypoxia ( PET,O2 =
194                                              Randomised order of clinician and self-samples from phar
195                                              Randomised order of clinician and self-samples from phar
196                     In an exploratory, block-randomised, parallel, double-blind, single-centre, place
197            Sixty-three participants for this randomised, parallel-group, double-blind, placebo-contro
198                                         This randomised, parallel-group, placebo-controlled, double-b
199 in the full analysis set, which included all randomised patients who received at least one dose of st
200                                       Of the randomised patients, 107 each were treated with fingolim
201  intention-to-treat population comprised all randomised patients, regardless of treatment administrat
202 escriptively across treatment groups for all randomised patients.
203                                      Six non-randomised phase 1/2A cell therapy group (CTG) trials we
204 the triplet therapy, are being compared in a randomised phase 2 trial (NCT01896999).
205  In this open-label, investigator-initiated, randomised phase 2 trial following a selection (or pick-
206                                            A randomised phase 3 clinical trial assessing the efficacy
207           In this multicentre, double-blind, randomised phase 3 trial (JADE MONO-1), patients (aged >
208 with doxorubicin as second-line therapy in a randomised phase 3 trial.
209        A prospective, pooled analysis of six randomised phase 3 trials was done to investigate diseas
210                            In the absence of randomised phase 3 trials, early clinical studies show i
211  In this prospective, pooled analysis of six randomised phase 3 trials, we included patients with sta
212             In this multicentre, open-label, randomised, phase 2 study, 11 different centres in the U
213           We did an open-label, multicentre, randomised, phase 2 trial at six hospitals in China.
214     ICON8 was an international, multicentre, randomised, phase 3 trial done across 117 hospitals in t
215                This multicentre, open-label, randomised, phase 3 trial, was done in 159 academic cent
216  18 countries), open-label, non-inferiority, randomised, phase 3 trial, we recruited adult patients (
217 s therapeutic approach has been validated in randomised, phase 3 trials, evaluation of response to ne
218  2b, multiarm, parallel group, double-blind, randomised placebo-controlled trial at 13 clinical neuro
219 clinical significance, there is a paucity of randomised, placebo-controlled clinical trial evidence w
220    HPTN 077 was a multicentre, double-blind, randomised, placebo-controlled phase 2a trial done at ei
221 atic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial.
222          For this multicentre, double-blind, randomised, placebo-controlled study done in 48 acute ca
223                   A 24-week, double-blinded, randomised, placebo-controlled trial (ClinicalTrials.gov
224          We did a multicentre, double-blind, randomised, placebo-controlled, dose-response study at 1
225                                      In this randomised, placebo-controlled, double-blind, phase 1 tr
226                                      In this randomised, placebo-controlled, double-blind, phase 3 tr
227                                      In this randomised, placebo-controlled, double-blind, phase 3 tr
228                                      In this randomised, placebo-controlled, four-sequence, four-peri
229         In this international, double-blind, randomised, placebo-controlled, phase 3 study (D-CARE),
230                        In this double-blind, randomised, placebo-controlled, phase 3 study, we enroll
231 an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 trial done at 18
232                     This was a double-blind, randomised, placebo-controlled, phase 3 trial that was d
233         In this ongoing (enrolment complete) randomised, placebo-controlled, phase 3 trial, patients
234                                 The phase 2, randomised portion of the trial is still enrolling.
235                        Further research in a randomised setting is needed to determine predictors of
236                         MATERIALS/METHODS: A randomised single-blind controlled trial of IIV in autoH
237 s an investigator-initiated, open-label, non-randomised, single-arm, single centre, phase 2 trial in
238                            Future larger and randomised studies are needed to clarify activity in hig
239 t recommendations and controlled, preferably randomised studies are warranted in order to formulate e
240                                   We did two randomised studies at two centres in Belgium.
241                           Fourth, use of non-randomised studies for the evaluation of clinical benefi
242          To our knowledge, this is the first randomised study of an ATR inhibitor in any tumour type.
243 n a multicentre, parallel-group, open-label, randomised study, children (aged 0-17 years) attending 1
244 opensity score matching resulted in a pseudo-randomised sub-cohort balancing baseline demographic and
245 lel-group, multicentre, open-label, two-arm, randomised superiority trial included adults (aged 16 ye
246 al is ongoing, with 55 patients remaining on randomised therapy as of Feb 20, 2020.
247                                              Randomised therapy was discontinued in 973 (32.4%) patie
248                       Eligible children were randomised to dolutegravir in ODYSSEY and weighed 20 kg
249 ealthy University of Cambridge students were randomised to join an 8-week mindfulness course (N = 27)
250 iple sclerosis (MS) (aged 10-<18 years) were randomised to once-daily oral fingolimod (n=107) or once
251 ea Scoring Index (F-VASI) at week 24 were re-randomised to one of three higher ruxolitinib cream dose
252 pant participants and 5 (3%) of 186 of those randomised to placebo.
253 ons, all mild, reported by five participants randomised to rosuvastatin, and one serious adverse even
254 thout detected resistance and those who were randomised to standard of care received NNRTI-based firs
255  Efficacy analyses were done in all patients randomised to three nested cohorts: patients with BRCA m
256 ed to three categories "Design acceptable", "Randomised to treatment groups", so of doubtful validity
257         Outcomes of GDM-affected pregnancies randomised to treatment with metformin, glyburide, or in
258 as first introduced in 2006 during a cluster randomised trial conducted before nationwide introductio
259                                              Randomised trial data assessing the safety and efficacy
260  AFFIRM-AHF was a multicentre, double-blind, randomised trial done at 121 sites in Europe, South Amer
261                     ARUBA was a non-blinded, randomised trial done at 39 clinical centres in nine cou
262 ion Project study was a pair-matched cluster-randomised trial done in 30 communities across Botswana
263                                  Multicenter randomised trial in 15 hospitals in the Netherlands.
264 with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark
265 ic, outcome-assessor-blinded, parallel-group randomised trial in 3 Australian hospitals in Sydney and
266 randomised, double-blind, placebo-controlled randomised trial in 39 UK hospital centres.
267 evaluated using data from a large, household-randomised trial in Hounde, Burkina Faso and Bougouni, M
268                              In this cluster-randomised trial in Kumasi, Ghana and Ibadan, Nigeria, w
269           DEEP-2 was a phase 3, multicentre, randomised trial in paediatric patients (aged 1 month to
270                             We did a cluster randomised trial in rural refugee settlements in norther
271                       We conducted a cluster randomised trial in which 75 schools were randomised (1:
272              We embedded a pragmatic cluster-randomised trial into Uganda's national LLIN campaign to
273                                A prospective randomised trial is needed to evaluate whether a second
274 efits or risks in settings, in which doing a randomised trial is not feasible.
275 icipants with Lynch syndrome enrolled into a randomised trial of daily aspirin versus placebo.
276                           RIVER is the first randomised trial to determine the effect of ART-only ver
277 lticentre, pragmatic, three-arm, superiority randomised trial, patients referred to secondary care fo
278 single-centre, double-blind, parallel-group, randomised trial, patients with advanced cancer, aged at
279                In this multicentre, phase 3, randomised trial, untreated patients aged 18 years or ol
280                              In this cluster-randomised trial, we included 30 health centres offering
281            In a double-blind, parallel-group randomised trial, we recruited adult participants identi
282                              In this cluster-randomised trial, we recruited participants aged 15 year
283             In this multicentre, open-label, randomised trial, we recruited patients with uncomplicat
284 udy met criteria to move forward to a future randomised trial.
285 risons are increasingly being considered for randomised trials assessing the efficacy of surgical int
286 aluating a product's net clinical benefit in randomised trials compared with current known effective
287                                    Community randomised trials have had mixed success in implementing
288                                     Previous randomised trials have shown an overwhelming benefit of
289 wo single-centre, multi-site, partly-masked, randomised trials in healthy cohorts of children (aged 1
290                                              Randomised trials of intravenous alteplase versus standa
291                         Fifth, efficiency of randomised trials should be improved by streamlining pat
292                                       Whilst randomised trials show that children exposed to less-hea
293 We undertook two parallel, pragmatic cluster-randomised trials using balanced incomplete block design
294 k meta-analyses based on existing and future randomised trials.
295 KD, but this requires testing in prospective randomised trials.
296           Ten participants assigned to a non-randomised, unblinded ChAdOx1 nCoV-19 prime-boost group
297                           We did a household-randomised, unblinded trial (DO ART) of delivery of ART
298 servation period, eligible participants were randomised using an interactive web response system to o
299 5, and April 11, 2017, 197 kidney pairs were randomised with 106 pairs transplanted into eligible rec
300               Twenty-two studies (n = 2,801) randomised women to metformin versus insulin, 8 studies

 
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