ライフサイエンスコーパス: rate-limiting

1 resence of Mg(2+), the chemical step becomes rate limiting.

2 ps at heme junctions that would otherwise be rate limiting.

3 in which the transfer of the methyl group is rate limiting.

4 xygen species, rather than cytochrome c, are rate limiting.

5 how that both rates are fast, and neither is rate-limiting.

6 ment step, rather than iminium formation, is rate-limiting.

7 sport at the PB thin film is shown not to be rate-limiting.

8 ass transfer across the cell membrane became rate-limiting.

9 and/or mass-transfer into the periplasm were rate-limiting.

10 mechanism and that the activation of O(2) is rate-limiting.

11 e typically annotated is labor intensive and rate-limiting.

12 phosphorylated by cellular kinases which is rate-limiting.

13 nd (13)C kinetic isotope effect studies, the rate-limiting and enantiodetermining step of the reactio

14 dies showed that cleavage of the C-H bond is rate-limiting and formation of the strained four-membere

15 ic substrate-binding site that modulates the rate-limiting aspects of the transport mechanism(4,5), i

16 may not be comparable if drug absorption is rate-limiting at this stage.

17 ence of substrate ligation to Mg(II), with a rate-limiting barrier (19.3 kcal/mol) in close agreement

18 t states, suggests that CoQ oxidation may be rate limiting because of unequal access of CoQ to the ac

19 ving C-H oxidative cleavage and a subsequent rate-limiting beta-H transfer step.

20 dissociation from the cellulose substrate is rate limiting, but the molecular mechanism of this step

21 ycinate and the nucleophile, consistent with rate-limiting C-C bond formation.

22 red carbonylative coupling route follows the rate-limiting C-H activation process via the concerted m

23 vity reflects the ability of Zn to promote a rate-limiting C-H reductive elimination step, and calcul

24 haracter of the transferring hydrogen in the rate-limiting C-H reductive elimination transition state

25 at a set of pupal wing enhancers for the key rate-limiting cell cycle regulators Cyclin E (cycE), E2F

26 A negative activation heat capacity for the rate-limiting chemical step leads directly to prediction

27 at rapid substrate-catalyst binding precedes rate-limiting chlorenium attack, controlling the face se

28 Rca is a key regulator of the rate-limiting CO(2)-fixing reactions of photosynthesis.

29 Deoxyguanosine kinase (dGK) is an essential rate-limiting component of the mitochondrial purine nucl

30 termine the transition-state ensemble of the rate-limiting conformational transition in the enzyme ad

31 , PT from Tyr precedes O-O elongation and is rate-limiting, consistent with available kinetic data.

32 s showed that the coupling process occurs by rate-limiting deprotonation of a hydrazine-bound arylpal

33 Rate-limiting diffusion across cytoplasm was demonstrate

34 and the surface layer over cycling enforce a rate-limiting diffusion barrier for the electron transpo

35 roduct release in sesquiterpene synthases is rate limiting due to the hydrophobic nature of sesquiter

36 ng factor (PAF) is implicated as a potential rate-limiting effector agent.

37 a cofactor-independent enzyme that catalyzes rate-limiting electron transfer between its substrate an

38 irect electron transfer, and NMO accelerates rate-limiting electron transfer by strongly lowering the

39 result in low-affinity, nonspecific binding; rate-limiting engagement of the second site enables high

40 expression of tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine catalysis, could be enh

41 ed with tryptophan hydroxylase 1 (Tph1), the rate limiting enzyme regulating peripheral serotonin syn

42 Expression levels of the rate-limiting enzyme aromatase, but not estrogen recepto

43 sitivity was driven by HMGCR expression, the rate-limiting enzyme for cholesterol synthesis, which co

44 r of adipose triglyceride lipase (ATGL), the rate-limiting enzyme for intracellular lipolysis.

45 FADS1 encodes a rate-limiting enzyme for omega-3 and omega-6 fatty acid

46 ed ex vivo, and identify DECR1, encoding the rate-limiting enzyme for oxidation of polyunsaturated fa

47 yltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthe

48 NCED3 encodes a rate-limiting enzyme for stress-induced ABA synthesis.

49 ssion of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme for the classical pathway of bile s

50 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in 5-HT biosynthesis.

51 histone deacetylation at the YUCCA8 locus, a rate-limiting enzyme in auxin biosynthesis, at warm temp

52 aised against tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis.

53 ualene monooxygenase, EC 1.14.99.7) is a key rate-limiting enzyme in cholesterol biosynthesis.

54 Interestingly, HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, was reduc

55 Squalene monooxygenase (SM) is a rate-limiting enzyme in cholesterol synthesis.

56 ox (am) ine 5'-phosphate oxidase (PNPO) is a rate-limiting enzyme in converting dietary vitamin B6 (V

57 It inhibits IMP dehydrogenase, a rate-limiting enzyme in de novo synthesis of guanidine n

58 de reductase regulatory subunit M2 (RRM2), a rate-limiting enzyme in dNTP synthesis, induced prematur

59 on of ACC Synthase 7 (ACS7), which encodes a rate-limiting enzyme in ethylene biosynthesis.

60 l-CoA desaturase FAT-7, an oxygen consuming, rate-limiting enzyme in fatty acid biosynthesis.

61 sphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, at Ser90.

62 monophosphate dehydrogenase 2 (IMPDH2), the rate-limiting enzyme in GTP biosynthesis.

63 amide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide metabolism, demonst

64 f microsomal prostaglandin E synthase-1, the rate-limiting enzyme in PGE(2) synthesis, sensitized OXR

65 ical ripening but also the expression of the rate-limiting enzyme in PGE2 synthesis-namely, cyclooxyg

66 osphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in phosphatidylcholine (PC) synthes

67 ine/spermine acetyltransferase (SAT1) is the rate-limiting enzyme in polyamine catabolism and a prima

68 /spermine N1-acetyltransferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism, has broad

69 adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required

70 phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in serine synthesis.

71 11B2) gene encodes aldosterone synthase, the rate-limiting enzyme in the biosynthesis of aldosterone.

72 Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the biosynthesis of deoxyribonuc

73 inhibitors of the ectonucleotidase CD39, the rate-limiting enzyme in the conversion of ATP to immunom

74 levulinate synthase 2 (ALAS2), the first and rate-limiting enzyme in the heme biosynthetic pathway.

75 ells of people with DS overexpress IDO1, the rate-limiting enzyme in the kynurenine pathway (KP) and

76 amide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage pathway, which a

77 ide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD(+) salvage pathway from

78 decarboxylase (Gad1), which encodes GAD67, a rate-limiting enzyme in the production of gamma-aminobut

79 ryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies,

80 es retinaldehyde dehydrogenase 2 (RALDH2), a rate-limiting enzyme in the retinoic acid (RA)-producing

81 stribution of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines

82 r composed of RRM1 and RRM2 subunits, is the rate-limiting enzyme in the synthesis of deoxyribonucleo

83 CHKB is a rate-limiting enzyme in the synthesis of phosphatidylcho

84 Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in the tryptophan-kynurenine pathwa

85 synthesis by conditional inactivation of the rate-limiting enzyme Nsdhl or treatment with cholesterol

86 osynthesis, such as Hmgcr, which encodes the rate-limiting enzyme of cholesterol biosynthesis called

87 y-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme of de novo cholesterol (Chol) synth

88 High expression of the rate-limiting enzyme of de novo GTP synthesis is associa

89 oline cytidylyltransferase A (CCTalpha), the rate-limiting enzyme of de novo PC biosynthesis pathway,

90 rs expressing tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, were also ob

91 rther show that the CPT1/whd (withered), the rate-limiting enzyme of FAO, is transcriptionally regula

92 Importantly, the rate-limiting enzyme of fatty acid biosynthesis, acetyl-

93 We also found that glycerol can induce a rate-limiting enzyme of GNG, glucose-6-phosphatase.

94 ructose-6-phosphate amidotransferase 1), the rate-limiting enzyme of HBP, promotes cardiomyocyte grow

95 etoacid-CoA transferase (SCOT) activity, the rate-limiting enzyme of ketone body utilization, in the

96 rnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) tr

97 ression of the gene Cpt1a, encoding CPT1A, a rate-limiting enzyme of mitochondrial fatty acid oxidati

98 hoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme of serine synthesis, is frequently

99 ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that prod

100 ytogenes lacking the gene hmgR, encoding the rate-limiting enzyme of the mevalonate pathway, had a do

101 Dependence on another rate-limiting enzyme of the NAD synthesis pathway, NAMPT

102 amide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the NAD(+) salvage pathway, gove

103 The rate-limiting enzyme of the pathway, glutamine-fructose

104 PI3K/AKT activation stabilizes G6PD, the rate-limiting enzyme of the PPP, by inhibiting the newly

105 1 (acyl-CoA oxidase 1) encodes the first and rate-limiting enzyme of the very-long-chain fatty acid (

106 ide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme, converting nicotinamide into nicot

107 ethylthioadenosine phosphorylase (MTAP), the rate-limiting enzyme, to relieve strain.

108 lencing of molecular expression of the Taxol-rate limiting enzymes (GGPPS, TDS, DBAT and BAPT) by qPC

109 rescent images presented upregulation of the rate-limiting enzymes for the production of dopamine and

110 or example, TCDD flattened expression of the rate-limiting enzymes in both gluconeogenesis (Pck1) and

111 -carboxylic acid (ACC) synthases (ACSs), the rate-limiting enzymes in ethylene biosynthesis.

112 1 (WT1), which drives the expression of two rate-limiting enzymes in retinol metabolism.

113 blot analysis shows significant increase in rate-limiting enzymes of pentose-phosphate pathway and 1

114 female mice revealed decreased expression of rate-limiting enzymes of triacylglycerol synthesis but i

115 Most work has focused on the two rate-limiting enzymes: 3-hydroxy-3-methylglutaryl CoA re

116 The rate limiting factor for inferring an association betwee

117 ts indicate that crRNAs selection is a major rate limiting factor in T4 phage engineering via CRISPR/

118 hat their adsorption to the surface can be a rate-limiting factor for cold sintering.

119 BRF1 is a rate-limiting factor for RNA Polymerase III-mediated tra

120 and in vivo, suggesting that DNAJB9 may be a rate-limiting factor in CFTR ERAD pathway.

121 As Axin is a rate-limiting factor in Wingless signaling, its regulati

122 eer progression with men in nursing, and the rate limiting factors with the female workforce.

123 , and in zebrafish, nuclear RBP-J levels are rate-limiting factors for Notch signaling in mammalian c

124 of alpha-helices 1 and 3 is reflected in the rate-limiting folding step, fast pressure-drop relaxatio

125 sport and N-terminal peptide trimming become rate limiting for Ag presentation.

126 istone depletion rather than DSB movement is rate limiting for HDR.

127 1a, suggesting that loss of cell identity is rate limiting for pancreatic tumor initiation.

128 ells, a process that increases ploidy and is rate limiting for the expression of ecdysone biosyntheti

129 Replenishment only becomes rate-limiting for recovery from paired-pulse depression

130 ergy metabolism to lipid biosynthesis and is rate-limiting for the de novo synthesis of lipids.

131 se included mutants defining genes that were rate-limiting for the onset of mitosis and of the S-phas

132 5/LHW transcription factor complex, which is rate-limiting for vascular cell proliferation in Arabido

133 (1, 10, 50, or 100 mum), which bypasses the rate-limiting HBP enzyme.

134 s within germinal centers (GCs) and requires rate-limiting "help" from follicular helper CD4(+) T (Tf

135 hesis or uptake by overexpressing either the rate-limiting heme synthesis enzyme ALAS1 or uptake prot

136 This demonstrates that PI3P is rate limiting in some pathways.

137 uction of the SnSe(2) to SnSe and Se that is rate limiting in the formation of the alloy and not the

138 However, data analysis is often rate-limiting in high-throughput enzyme assays, as manua

139 ormal dynamic range of ERK signalling is not rate-limiting in single cells during differentiation.

140 o that, there is no evidence for a distinct, rate-limiting initiation event.

141 luorescence enhancement that occurred in the rate limiting isomerization step, the sensors described

142 1a complexes, calcium binding is followed by rate-limiting isomerization.

143 2+)-dependent manner, Ca(2+) binding was the rate-limiting kinetic step for this interaction.

144 ith the constituents of skin's outermost and rate limiting layer stratum corneum (SC), and increase i

145 tylation leading to up-regulation of several rate-limiting lipogenic enzymes and fibrogenic factors.

146 lycolysis via proteasomal degradation of the rate-limiting metabolic enzyme phosphofructokinase (PFK)

147 he 12-hour oscillatory transcription of many rate-limiting metabolic genes known to have perturbation

148 e fluidity and impairs lipid homeostasis via rate-limiting metabolic processes in fatty acid monounsa

149 GlcNAc is a rate-limiting metabolite for N-glycan branching.

150 ng pathway by preventing the maturation of a rate-limiting multiprotein complex necessary for IKK act

151 t knockout (BANKO) mice because NAMPT is the rate-limiting NAD(+) biosynthetic enzyme.

152 leation sites on an existing MT, followed by rate-limiting nucleation of branches, reproduces the mea

153 This pathway involves the rate-limiting nucleophilic attack of a water molecule, l

154 nformational changes in EF-Tu coordinate the rate-limiting passage of aa-tRNA through the accommodati

155 a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine d

156 in large quantities represents a costly and rate-limiting prerequisite for high throughput screening

157 anism as that of monomers, implying that the rate-limiting primary nucleus is larger than a dimer and

158 he ground excitonic state is found to be the rate-limiting process.

159 e tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization re

160 cts are consistent with a mechanism in which rate-limiting proton transfer is an important contributo

161 ctive species, 1,2-insertion of propene, and rate-limiting protonolysis of the resultant alkyl by the

162 Irreversible and turnover-rate limiting reaction with pinacolborane (k ~ 7 x 10(-3

163 A critical and often rate-limiting reaction in aromatic catabolism is O-aryl-

164 They catalyze the rate-limiting reaction in the conversion of cellobiose t

165 which is mainly due to the activation of the rate-limiting reaction.

166 Thus, FoxO-regulated genes play a rate-limiting role in increased protein degradation and

167 in vivo, and explain previous findings of a rate-limiting role of iron in adipose tissue browning.

168 Rate law analyses reveal that the rate limiting step for each catalyst involves the accumu

169 f the 2-OG dehydrogenase complex (OGDHc)-the rate limiting step for mitochondrial 2-OG metabolism.

170 We establish that the main rate limiting step for protein synthesis and the methion

171 reduction by substrate is rate limiting, the rate limiting step in turnover of high potential MCOs is

172 This rate-limiting step also corresponded to and was sufficie

173 des (PS-ASOs) from late endosomes (LEs) is a rate-limiting step and a poorly defined process for prod

174 mechanistic studies provide insights on the rate-limiting step as well as the structure of the actua

175 lay between these movements implies a single rate-limiting step dependent on ATP binding and transien

176 t the gamma-C(sp(3) )-H bond cleavage is the rate-limiting step during the reaction process.

177 ind that substrate unfolding constitutes the rate-limiting step during translocation.

178 t that the C(sp(3))-H bond activation is the rate-limiting step for both the catalytic processes.

179 predict that under operating conditions the rate-limiting step for oxygen incorporation from O(2) ga

180 The rate-limiting step for the activation of STING is its tr

181 ilizing the COOH* intermediates and tune the rate-limiting step from the formation of adsorbed interm

182 s in vitro The results identify an important rate-limiting step in assembly and reveal new insights i

183 Initiation is a rate-limiting step in cap-dependent translation and is t

184 gest that the FRQ-CK1 interaction is a major rate-limiting step in circadian period determination.

185 t tyrosine kinase activation is not the only rate-limiting step in CLEC-2-induced activation of plate

186 toyltransferase that catalyzes the first and rate-limiting step in de novo sphingolipid biosynthesis.

187 ons at a rate nearly 10-fold faster than the rate-limiting step in electron transport.

188 ric synthesis remains both a challenge and a rate-limiting step in enzyme discovery.

189 KIBRA is not the rate-limiting step in facilitation since overexpression

190 activates GPAT4, which catalyzes the initial rate-limiting step in glycerolipid synthesis.

191 se (SCD1, SCD), an enzyme that catalyzes the rate-limiting step in monounsaturated fatty acid synthes

192 We find that the rate-limiting step in mRNA cleavage frequently involves

193 iological functions including catalyzing the rate-limiting step in NAD synthesis.

194 g kinase (NIK, also known as MAP3K14) is the rate-limiting step in non-canonical NF-kappaB pathway ac

195 se-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthe

196 ns at a rate nearly 10 times faster than the rate-limiting step in photosynthetic electron transport.

197 nzymatic hydrolysis, which is considered the rate-limiting step in polyester biodegradation.

198 -trans isomerization of xaa-proline bonds, a rate-limiting step in protein folding which has been sho

199 In eukaryotes, ribosome assembly is a rate-limiting step in ribosomal biogenesis that takes pl

200 Although STING ER exit is the rate-limiting step in STING signaling, the mechanism tha

201 thesis of 5-aminolevulinic acid (ALA) is the rate-limiting step in tetrapyrrole biosynthesis in land

202 Retinol dehydrogenases catalyze the rate-limiting step in the biosynthesis of retinoic acid,

203 ioxygenase (TaNCED-5BS), which catalyzes the rate-limiting step in the biosynthesis of the phytohormo

204 First, the rate-limiting step in the catalytic cycle is the formati

205 ydroxylase (CYP7A1) performs the initial and rate-limiting step in the classical pathway, and sterol

206 regulation of proteostasis is a critical and rate-limiting step in the consolidation of new memories(

207 IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine n

208 des a powerful approach for overcoming a key rate-limiting step in the design and construction of an

209 tional theory calculations, we show that the rate-limiting step in the ENRR is likely the initial N=N

210 esulting from the C-terminal cleavage is the rate-limiting step in the formation of fully cleaved Va.

211 amine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in the kynurenine pathway of tryptoph

212 It becomes the rate-limiting step in the spinodal region.

213 -prenyltransferase (cis-PTase) catalyzes the rate-limiting step in the synthesis of glycosyl carrier

214 The rate-limiting step in the two-step sequence depends on t

215 ve analysis of this demonstrates CymA is the rate-limiting step in this electron conduit.

216 genic substrate, and its availability is the rate-limiting step in this pathway.

217 ing lesions, with the promotion stage as the rate-limiting step in tumor formation.

218 The rate-limiting step is formation of an activated copper c

219 on, (b) not inhibited by product and (c) the rate-limiting step is most likely the C-C bond formation

220 dissect complex biological processes, but a rate-limiting step is often the cloning of targeted gene

221 In addition, the rate-limiting step is shown to be the cyclization of the

222 Whether the rate-limiting step occurs early or late in the evolution

223 of activation or repression depending on the rate-limiting step of a given promoter's basal initiatio

224 cetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induce

225 rogenase that is required for the second and rate-limiting step of branched amino acid catabolism and

226 n dispersion experiments as well as with the rate-limiting step of catalytic turnover.

227 Prolidase catalyzes the final and rate-limiting step of collagen degradation during BBB re

228 Ribonucleotide reductase (RNR) catalyzes the rate-limiting step of de novo synthesis of deoxyribonucl

229 catalyzing the crucial hypusination and the rate-limiting step of elF5A activation.

230 he prominent role played by exosite 2 in the rate-limiting step of factor V activation.

231 t Trp(72) impairs cholesterol efflux and the rate-limiting step of HDL biogenesis both in vitro and i

232 rsion to N-formylkynurenine in the first and rate-limiting step of kynurenine pathway.

233 leamine 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-limiting step of L-tryptophan metabolism, and emerg

234 A carboxylase, which catalyzes the first and rate-limiting step of lipid biosynthesis), as well as in

235 hortening, also termed deadenylation, is the rate-limiting step of mRNA degradation in eukaryotic cel

236 Our data demonstrate that the rate-limiting step of PrimPol-catalyzed DNA elongation d

237 ained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that foll

238 tion - the correlation is linear because the rate-limiting step of the catalytic cycle, nucleotide re

239 The second and rate-limiting step of the de novo phosphatidylcholine bi

240 tification has been widely recognized as the rate-limiting step of the experimental workflow.

241 ferase (GFAT), the enzyme that catalyzes the rate-limiting step of the hexosamine biosynthesis pathwa

242 dynamic drivers of enzyme catalysis for the rate-limiting step of the industrially important enzyme

243 2,3-dioxygenase 1 (IDO1) that catalyzes the rate-limiting step of the pathway.

244 icated that one proton is transferred in the rate-limiting step of the reaction at pD 7.0.

245 The rate-limiting step of the transport cycle is the dissoci

246 y when physiologically oriented and that the rate-limiting step of the transport cycle varies with th

247 of the transporter, likely representing the rate-limiting step of the transport process.

248 control lipid A biogenesis, focusing on the rate-limiting step performed by LpxC.

249 e been extensively investigated but the main rate-limiting step that determines circadian period rema

250 mental CO polarization curve and reveals the rate-limiting step to be *COOH to *CO at low overpotenti

251 ich and electron-poor arenes showed that the rate-limiting step varies with the electronic properties

252 tion mechanism for NDMA reduction, where the rate-limiting step was a direct electron transfer reacti

253 l complexes have been characterized, and the rate-limiting step was shown to be reductive elimination

254 The DFT results showed that the rate-limiting step was the first electron abstraction fr

255 ggest that anatomical modifications are the 'rate-limiting step' in each trajectory, which in large p

256 f the flap, product release is no longer the rate-limiting step, implying that the flap is important

257 binding events are productive and implies a rate-limiting step, probably associated with recruitment

258 H the OH(-) anion nucleophilic attack is the rate-limiting step, which changes at high pH to the O-O

259 tial allenic C(sp(3))-H bond cleavage is the rate-limiting step, which was supported by DFT calculati

260 Methane activation is the rate-limiting step, while the activation of CO(2) and th

261 hich under certain circumstances becomes the rate-limiting step.

262 ncovering o-quinone methide formation as the rate-limiting step.

263 dination of the pyridine nitrogen and is the rate-limiting step.

264 D) ~ 1.7), suggesting proton transfer in the rate-limiting step.

265 gradation, consistent with decapping being a rate-limiting step.

266 ropargylic position was determined to be the rate-limiting step.

267 of H to the aromatic ring is involved in the rate-limiting step.

268 es suggest that C-H activation step may be a rate-limiting step.

269 he long-standing controversy surrounding the rate-limiting step.

270 ether, these data show that HS17B3 acts as a rate-limiting-step for the maximum level of testosterone

271 d unactivated amide consist of two different rate limiting steps: the formation of Cu-H monomer from

272 Our results thus revealed that different rate-limiting steps (e.g., substrate channel diffusion)

273 scription start site (TSS) is one of the key rate-limiting steps in regulating genome-wide gene expre

274 nate T cells represents the most crucial and rate-limiting steps in the development of personalized c

275 ered to be of importance for hemostasis, the rate-limiting steps of CLEC-2-induced platelet activatio

276 ring and signalosome formation are among the rate-limiting steps of CLEC-2-mediated platelet activati

277 uent refolding and provides key insight into rate-limiting steps of G-quadruplex conformational dynam

278 Given that rate-limiting steps of metastasis are known to occur whi

279 n a dimer that reduces the energy barrier of rate-limiting steps of the catalytic cycle of Ca(2+) tra

280 ichiometric analysis to identify potentially rate-limiting steps underpinning diurnal malate mobilisa

281 proofreading, and translocation, focusing on rate-limiting steps, structural elements that modulate t

282 racterized by a global model with three main rate-limiting steps.

283 glc levels suggesting one or more downstream rate-limiting steps.

284 ce and clinical translation are the greatest rate-limiting steps.

285 We provide evidence that malonyl-CoA, the rate-limiting substrate for fatty acid synthesis (FAS),

286 evidence that none of those provide the sole rate-limiting substrate for PBP2 binding.

287 PRPP is a rate-limiting substrate for purine nucleotide synthesis,

288 ctively enriches polyunsaturated lipids, the rate-limiting substrates for lipid peroxidation, by acti

289 upregulating the sps gene, which encodes the rate-limiting sucrose-phosphate synthase enzyme.

290 Consistently, overexpression of VTC2, the rate-limiting synthetic enzyme in AsA biosynthesis, prom

291 ticular, GRU102 showed reduced activity of a rate-limiting TCA cycle enzyme, alpha-ketoglutarate dehy

292 tial MCOs where T1 reduction by substrate is rate limiting, the rate limiting step in turnover of hig

293 ich multiple T cell responses share a common rate-limiting threshold and a conceptually simple model

294 to the cytoplasmic side of the membrane, is rate limiting to transport.

295 These coupled steps are the rate-limiting transition for the ATPase cycle suggesting

296 that attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle.

297 tify significant C-H bond elongation in both rate-limiting transition states and suggest that the lar

298 cts our kinetic measurements and reveals the rate-limiting transition where laterally associated alph

299 re fast, eliminating these steps as possible rate-limiting transitions.

300 HD5 is an essential coactivator of ATGL, the rate-limiting triglyceride (TG) lipase in many cell type