ライフサイエンスコーパス: rational

1 beliefs and desires that would have made it rational.

2 forming available methods currently used for rational Ab engineering.

3 lves wrestling with the urge to commit a non-rational action.

4 psychosocial nature of the devoted actor and rational actor frameworks, focusing on how sacred values

5 ve language use, an environment where social rational agents routinely deal with resource constraints

6 ld be considered for clinical trials testing rational agents to overcome de novo enzalutamide resista

7 develop a model of social information use by rational agents with differing preferences, and demonstr

8 the best course of action calculated through rational algorithms.

9 itive constraints, and the scope or resource rational analysis (RRA).

10 Lieder and Griffiths advocate for resource-rational analysis as a methodological device employed by

11 Lieder and Griffiths introduce resource-rational analysis as a methodological device for the emp

12 We agree that combining rational analysis with cognitive bounds, what we previou

13 Resource-rational analysis would profit from being integrated mor

14 resent the computational framework "resource-rational analysis" to address the reverse-engineering pr

15 previously introduced as Cognitively Bounded Rational Analysis, is a promising and under-used methodo

16 overcome some of the challenges of resource-rational analysis.

17 ties through the use of aprotic solvents for rational analysis/design in electrosynthesis, microfabri

18 Here, we present a rational and dynamic virus nomenclature that uses a phyl

19 This thereby extracts rational and interpretable thoughts of the agent from it

20 cal analyses are presented together with the rational and parameters employed to study MET devices an

21 n may complement clinical judgement, support rational and shared treatment decisions, and establish s

22 r oxide hybrids with tunable dimensions in a rational and well-reproducible fashion, is reported.

23 orts to develop computational tools to guide rational antibody engineering, most approaches are of li

24 ion of these CoV interferon antagonists is a rational approach for generating candidate vaccines to p

25 Here, we report on a rational approach for the identification of alpha-2,8-PS

26 Here, we present a rational approach that enhances the membrane selectivity

27 ssociation of RAS has long been considered a rational approach to anticancer therapy, which led to th

28 reciated transmission dynamics and support a rational approach to reactive case detection strategies

29 sfies many of the desiderata of the resource-rational approach, but in a more disciplined manner.

30 The "resource-rational" approach is ambitious and worthwhile.

31 )(2+)) remains a challenging problem, as few rational approaches are available for modulating the rea

32 Resource-rational approaches offer much promise for understanding

33 This review discusses rational approaches to stability and crystallinity engin

34 estigation as immunotherapies, and show that rational ASO selection can be used to prevent unintended

35 Herein, we report the rational assembly of a series of transition metal hydrox

36 ereological probes are efficient and allow a rational assessment if the numbers that have been genera

37 Comprehensive accounts of resource-rational attempts to maximise utility shouldn't ignore t

38 e tendon ECM microenvironment will provide a rational basis for an ECM-based approach for tendon repa

39 de insight into the etiology of cancer and a rational basis for targeted combination therapy.

40 ructural details of this mechanism provide a rational basis for therapeutic strategies to inhibit alp

41 These results provide a rational basis to address the heretofore unknown mechani

42 The key to a rational catalyst design is understanding the descriptor

43 le, its consideration in the early phases of rational chemical design is therefore challenging.

44 sibility of modifying their activity through rational chemical or genetic approaches.

45 ivities constitute a better electrophile for rational chemical probe and therapeutic molecule design.

46 d to be inconsistent with the assumptions of rational choice theory.

47 d how they change in disease states to allow rational choices of drugs targeting the specific peptida

48 ell death induced by CX-5461 is critical for rational clinical development in these patients.

49 A model of resource-rational cognition that accounts for these benefits may

50 Future studies of ivosidenib monotherapy or rational combination approaches should be considered in

51 e future of immunotherapy in AML lies in the rational combination of complementary immunotherapeutic

52 fortification through gene stacking, using a rational combination of conventional breeding and metabo

53 colytic and immunostimulatory activities and rational combination of PVs with other therapies.

54 l-like triple-negative breast cancer through rational combination of STAT3 and GR inhibitors.

55 predictors of response to immunotherapy and rational combination therapies that can enhance efficacy

56 in fibroblast-rich tumors and the design of rational combination therapies to restore drug sensitivi

57 targeting CD39, including their inclusion in rational combination therapies.

58 o-stimulatory blockade approaches, including rational combinations of immune inhibitory agents, and d

59 However, rational comparisons of multiple batches of experiments

60 h imposed limitations on availability may be rational considering the fiduciary responsibilities of p

61 We apply a method, inverse rational control (IRC), to learn an agent's internal mod

62 Rational control of the self-organization of beta-peptid

63 We describe the theoretical rationales, current states of the science, field-wide ch

64 In making the case that "rationalization is rational," Cushman downplays its signature liability: Ra

65 es of information in working memory (WM) for rational decision making that leads to social-distancing

66 ive' or 'irrational', or our supposedly more rational deliberative one.

67 ation of the S-protein can be controlled via rational design and can provide a framework for the deve

68 To assist the rational design and clinical translation of the therapeu

69 Herein, we report the rational design and development of the first potent pept

70 Developing algorithmic approaches for the rational design and discovery of materials can enable us

71 ic improvement of carboxysomes have inspired rational design and engineering of new nanomaterials to

72 Rational design and fabrication of graphene nanoarchitec

73 ing and demonstrated capabilities enable the rational design and holistic engineering of novel materi

74 ent has been elusive but is critical for the rational design and improvement of antituberculosis (ant

75 n and tropism, can be coevolved by combining rational design and library-based evolution for clinical

76 Here, we combine rational design and library-based evolution to coevolve

77 results demonstrate that the combination of rational design and modular chemical synthesis can revit

78 r-induced interfacial effect and will enable rational design and molecular engineering of the filler-

79 of human diseases, robust platforms for the rational design and optimization of small molecules inte

80 Here, we report the rational design and optimized synthesis of electronicall

81 This is demonstrated through the rational design and preparation of layered electrode mat

82 We report the rational design and synthesis of a water-stable metal-or

83 Here we address this problem using a rational design approach to target TfR1-tropic arenaviru

84 asymmetric Diels-Alder reactions following a rational design approach.

85 d demonstrates the value of mechanism-driven rational design as a strategy for improving the catalyti

86 Here we present a rational design as well as functional and structural cha

87 largely enabled through the understanding of rational design concepts for more efficient polarizing a

88 cities, which in the long term may provide a rational design for novel inhibitors of MUC1-lectin inte

89 (Semi-) rational design has emerged as a powerful means to engin

90 Rational design involved incorporation of key amino acid

91 address this problem, we develop a two-step rational design method for the discovery of oligomer-spe

92 The rational design of 3D structures (MOFs, COFs, etc.) is p

93 In this manuscript, we report the rational design of a highly stable fluorogenic peptide (

94 ffers new insights and opportunities for the rational design of a new generation of electrocatalysts.

95 ctive responses develop is essential for the rational design of a subunit-based vaccine that would be

96 survey the main strategies explored for the rational design of a wide variety of different metal cat

97 This study provides fundamental insights for rational design of air-stable, electronically conductive

98 A rational design of an electrocatalyst presents a promisi

99 refore, complete escape-mutation maps enable rational design of antibody therapeutics and assessment

100 property relationships that would enable the rational design of better materials.

101 standing of the "intimacy criterion" for the rational design of bifunctional catalysts for the conver

102 Voltair can potentially guide the rational design of biocompatible electronics and enhance

103 hanisms is of fundamental importance for the rational design of catalysts and is also extremely chall

104 To advance the rational design of CF therapies, it is important to eluc

105 wing radiation that may be leveraged for the rational design of combinatorial strategies.

106 ion of BigDyn on ASICs could thus enable the rational design of compounds potentially useful in the t

107 The methods of DNA nanotechnology enable the rational design of custom shapes that self-assemble in s

108 The rational design of dengue virus (DENV) vaccines requires

109 ar principles, advance our understanding and rational design of dynamic polymer networks, improving o

110 on that can potentially be exploited for the rational design of effective SARS-CoV-2 therapeutics.

111 COVID-19 is vital for the identification and rational design of effective therapies.

112 ave been made in electrocatalysis due to the rational design of electrocatalysts at the nanoscale lev

113 uctures, and will expand the toolbox for the rational design of functional hierarchical nanostructure

114 ields spanning from biomineralization to the rational design of functional nanocomposites.

115 wisting and bridge-H bending motions enables rational design of functional proteins.

116 have a positive translational impact on the rational design of general microbiota-based therapeutics

117 ing observed in our study will assist in the rational design of guide RNAs for ADAR-mediated RNA base

118 1-S2 coupling mechanism that will facilitate rational design of high-affinity SERT allosteric inhibit

119 This work provides a methodology for the rational design of high-performance EIS muPADs and has t

120 nfections on human health and to improve the rational design of immune approaches to treatment of can

121 lopment of novel antituberculars through the rational design of improved MbtI inhibitors.

122 nA vaccines and provide a foundation for the rational design of improved therapies.

123 nd glucagon receptor has helped to drive the rational design of innovative peptide molecules that hol

124 Moreover, the NMR structure can guide rational design of ligands that target the PDGFR-beta vG

125 sis and provide critical information for the rational design of live attenuated vaccine candidates fo

126 at CoV G-N-7 MTase may be a novel target for rational design of live attenuated vaccines and antivira

127 methodology offers promise for revolutionary rational design of molecular magnets.

128 Next, advances involving the rational design of molecules composed of both metal-cont

129 s to how these might be closed such that the rational design of more effective and efficient material

130 This observation might assist with rational design of new catalysts.

131 t sizes and represents a key step toward the rational design of new heterogeneous catalysts.

132 These results provide the framework for the rational design of new therapeutic agents for treatment

133 emical stability is a novel approach for the rational design of next-generation batteries.

134 o provided that may pave the way towards the rational design of next-generation melanin-based functio

135 nanoclusters and a general strategy for the rational design of next-generation nano-probes, sensors

136 ), providing critical details to support the rational design of next-generation sorbents.

137 Structural studies can help advance the rational design of novel specific pharmaceuticals that t

138 novel plague vaccine candidate and that the rational design of OMVs could serve as a robust approach

139 Our observations encourage the rational design of optimized ThyX inhibitors that ultima

140 closing important structural information for rational design of PAICS inhibitors as potential antican

141 tial structural and functional knowledge for rational design of panserotype DENV capsid inhibitors.

142 Rational design of parent zeolites with concentrated and

143 er, it offers an efficient algorithm for the rational design of personalized probiotic cocktails to d

144 hage insensitivity must be characterized for rational design of phage cocktails.

145 Rational design of pharmaceutical drugs targeting integr

146 illuminating field of science rooted in the rational design of photochromic molecules for task-speci

147 ture elucidated by this study may enable the rational design of photoswitchable systems whose reactiv

148 these results will provide insight into the rational design of polymeric inhibitors and improve our

149 RE/rev association with implications for the rational design of potential drugs against HIV-1 infecti

150 ew-type model material system to explore the rational design of redox-active molecules in nonaqueous

151 These findings can guide the rational design of robust SNZVI with properties tailored

152 btleties will benefit future attempts in the rational design of salient therapeutic agents, including

153 pes, which also provides a framework for the rational design of selective and potent ligands for the

154 se findings may provide a foundation for the rational design of small molecule modulators of LLPS wit

155 its E3 ligase, increasing the potential for rational design of small molecule RGS2 protein stabilize

156 eristics in a predictable way, aiding in the rational design of small molecule semiconducting materia

157 model should provide a helpful tool for the rational design of strand-displacement reaction networks

158 These protocols may motivate the rational design of strategies for promoting longevity in

159 n of interactivity become inseparable in the rational design of such materials.

160 rovides a robust modelling framework for the rational design of synthetic communities with optimized

161 Through rational design of the polymer on the molecular level we

162 inone methide derivatives, aiding the future rational design of the reaction condition, structural mo

163 rs at the CDK7 active site and to aid in the rational design of therapeutic compounds.

164 orphology-function models that allow for the rational design of these devices, and in delivering insi

165 facilitated the discovery, optimization, and rational design of three major categories of oxide catho

166 Here, we demonstrate a rational design of triple combination regimen, including

167 gently being developed for SARS-CoV-2 to aid rational design of vaccines and therapeutics.

168 all, this study is paving the way toward the rational design or directed evolution of artificial ComR

169 or gene therapy applications have focused on rational design or library-based approaches that can add

170 m, presenting a comprehensive theory of five rational design principles for achieving giant intrinsic

171 ovel cross-linked proteins and enable a more rational design process.

172 We demonstrate a rational design strategy for repurposing venoms into pro

173 Here we apply a recently developed in silico rational design strategy to produce a bicyclic peptide t

174 Here we apply rational design to engineer a complete set of monomeric

175 Here, recent progress in the rational design, morphology, dynamics, and multi-functio

176 ry screening hit followed by structure-based rational design, we have identified a potent, reversible

177 he progress that is possible through careful rational design.

178 and NEMO using small molecule screening and rational design.

179 the second bromodomain of Brd4 validated the rational design.

180 s of SNZVI materials are unknown, preventing rational design.

181 e will have the foundation necessary for the rational development of an HIV-1 vaccine.

182 t understanding these effects can inform the rational development of fibrillation-resistant hCT analo

183 and brain pericytes, and are a resource for rational development of new brain-penetrant therapeutics

184 s that influence the reaction and aiding the rational development of new caging groups/catalysts for

185 transfer in these processes and impedes the rational development of new stereospecific cross-couplin

186 nowledge gained from these studies may guide rational development of novel antimalarial therapies and

187 derstanding the pathogenesis of TMUV and the rational development of novel TMUV vaccines.

188 on oxides are major stepping-stones toward a rational development of single-atom catalysts (SACs).

189 known inhibitor activity data and can inform rational drug design for this important antibiotic targe

190 dimers, and have important implications for rational drug design that targets these receptors.

191 s from distant proteins is a major hurdle to rational drug design.

192 e the dominant effector mechanism in driving rational drug designs for next-generation immunotherapie

193 e catalytic details of the enzyme and inform rational drug development against this pernicious virus.

194 88 and CXCR4 mutations in WM has facilitated rational drug development, including the development of

195 Rational drug discovery has greatly accelerated the deve

196 development of drug molecules: the rise of 'rational drug discovery' methodology in the 1970s, follo

197 These findings are critical for rational drug discovery, as limiting a virtual screen to

198 AS mutations pose substantial challenges for rational drug discovery.

199 Based on this information, we follow a semi-rational engineering approach using a FACS-based screeni

200 sigma factors in bacterial metabolism, their rational engineering for commercial metabolite productio

201 ults raise the intriguing possibility of the rational engineering of allosterically modulated DNA ori

202 Affinity to EGFR was finely tuned by rational engineering of aptamer sequences to define rece

203 To inform the rational engineering of collagen-like peptides and prote

204 erential adsorption study sheds light on the rational engineering of molecular interaction(s) with ac

205 These findings open up opportunities for rational engineering of pharmacologically enhanced sKlot

206 the host-range defect of MVA may allow more rational engineering of vaccines for efficacy, safety, a

207 a need for science-guided rational (or semi-rational) engineering to identify variants that replicat

208 These approaches may provide means for rational escalation and de-escalation treatment strategi

209 nclusions about transmission that can inform rational, evidence-based policies and reduce misinformat

210 We step back from presuming rational expectations and entertain potential belief dis

211 This study provides a rational explanation for the autoimmunity of patients wi

212 Altogether, our findings may underline a rational for targeting the actomyosin system in MPM.

213 ted HOMO -> LUMO configurations, providing a rational for the simultaneous tuning of E(T(1)) and E(S(

214 ptive anti-tumor immunity and provide strong rationales for combining telomere-targeting therapy with

215 To illuminate the rationales for sharing data, the technical challenges an

216 lationship of smNBEs in these reactions, and rationales for using smNBEs in many cases have also been

217 ediated beta-arrestin biased signaling and a rational framework for further optimization of fentanyl-

218 rationally justified when seen in the richer rational framework of the new paradigm.

219 r aim was to make progress toward developing rational frameworks for selecting electrode materials us

220 insight gained in this study will facilitate rational genetic engineering of NRPS to generate unnatur

221 cal systems, this methodology should provide rational guidelines for the development of viable electr

222 The present study has evidently provided a rational heterostructure strategy for improving various

223 , which impedes our understanding and limits rational improvements to reprogramming protocols.

224 ated by task demands, based on principles of rational inattention.

225 We investigated whether infants can make rational inferences about when and how to try on a novel

226 The resulting fentanyl-bound pose provides rational insight into a wealth of historical structure-a

227 erventions against these major pathogens are rational investments.

228 The proposed rational is based on current evidence, including real-li

229 Understanding these differences provides a rational management strategy for deciding when to contin

230 gether with our perspective on the future of rational materials design and discovery.

231 s of these methods and their applications in rational materials design, followed by a discussion on s

232 y solve some of our challenges on the way to rational materials design.

233 but also their biological targets provides a rational means for evaluating the merits and selectivity

234 In addition, a rational mechanism was presented for describing the reac

235 pports future TBI development by providing a rational method to compare different candidates.

236 Various rational methods have been devised to incorporate these

237 hanisms of fibrillation is key to developing rational mitigation strategies.

238 History can help refine the resource-rational model by uncovering how cultural and cognitive

239 Bioisosterism is widely employed in the rational modification of lead compounds, being used to i

240 Rational modifications in the deoxysugar functionality a

241 A rational modulation of the local configurations is essen

242 used as a medicinal chemistry tool to assist rational molecular design.

243 Macromolecular design in conjunction with rational monomer composition can direct architecture, se

244 ngle-component supramolecular polymer by the rational monomer design and paves the way toward the use

245 o extract more accurate beliefs from our non-rational motivations for behavior.

246 rse amino acids, thus laying the grounds for rational mutagenesis.

247 Rational new strategies are needed to treat tumors resis

248 e been developed as independent guide design rationales, no library has yet combined these into a sin

249 rrent immunotherapies via the development of rational novel combination treatments.

250 own with a finite precision and described by rational numbers.

251 This creates a need for science-guided rational (or semi-rational) engineering to identify vari

252 encoded or decoded may open new avenues for rational pharmacological targeting of PI3K-associated di

253 "boxology" belief-desire model depicting the rational planner, and it seems to us he fails to accommo

254 However, the rational preparation of heterostructures with highly act

255 t Lieder and Griffiths' method for analyzing rational process models cannot capture an important cons

256 These findings have implications for rational protein design and synthetic biology.

257 ase ion chemistry as a means of facilitating rational repurposing of the existing medicines for treat

258 ratios for each CO-RADS score were used for rational selection of diagnostic thresholds.

259 The classifier genes enable rational selection of patients who benefit best from a g

260 llectively, the results demonstrate that the rational selection of pulsing conditions and buffer comp

261 We hope to offer rational solutions to overcome some major fundamental ob

262 cting resurgence, and show the importance of rational spatial sampling schemes for several neglected

263 ations for both horizontal gene transfer and rational strain design.

264 These findings might also inspire rational strategies for developing liquid-repellent surf

265 xistence in chalcogenophosphates may lead to rational strategies for incorporation of ferroic functio

266 19 disease but also for the development of a rational strategy aimed at lifting confinement restricti

267 While a rational strategy for initiation of an economic reboot w

268 -taste relationships remains one of the most rational strategy to expand the chemical space associate

269 tial products are energetically similar, but rational structural perturbations can be employed to bre

270 These findings are expected to facilitate rational structure-based discovery of drugs targeting th

271 Our data enable the development of rational synergistic RLT-combination therapies to improv

272 crystal structure relations, that enable the rational synthesis of a heterostructured nanorod megalib

273 uit performance, paving the way towards more rational synthetic construct design in mammalian cells.

274 ve question will prove helpful to devising a rational system of SLK allocation and is applicable to o

275 of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes.

276 tailoring surveillance, whilst it may offer rational targets for the development of new prevention a

277 Dubey and Griffiths propose a rational theory of curiosity that unifies previously con

278 Rational therapeutic combinations, especially with immun

279 insights have informed potential avenues for rational therapeutic interventions.

280 at mouse models can identify mechanistically rational therapies for the clinic.

281 PLV-LMCs during murine development, towards rational therapies that target their proliferation, recr

282 o leverage this mechanistic knowledge toward rational therapies, a principal challenge will be the de

283 epigenome presents a unique opportunity for rational therapy for infants with PFA ependymoma.

284 There is a strong rational to accelerate the detection process of H. pylor

285 say combined with Cdk5-targeted therapy is a rational treatment approach for neuroendocrine malignanc

286 left palate will be an important step toward rational treatment of these complex anomalies.

287 ins, proposing CDK4/CDK6 inhibitors as a new rational treatment option for AML patients with NUP98-fu

288 of CO(2) to C(2) oxygenates, demonstrated by rational tuning of an assembly of nitrogen-doped nanodia

289 and provide a structure-based framework for rational vaccine design and the selection of robust immu

290 ent the continued spread of SARS-CoV-2; yet, rational vaccine design efforts are currently hampered b

291 hogenesis of malaria and will facilitate the rational vaccine design for malaria.

292 Reverse vaccinology (RV) is a milestone in rational vaccine design, and machine learning (ML) has b

293 Our studies provide new insights for rational vaccine design, indicating the importance of pr

294 ntions, in addition to providing insight for rational vaccine design.

295 fine protective epitopes that can be used in rational vaccine design.

296 mmunological memory and provide insights for rational vaccine design.

297 key aim which would significantly accelerate rational vaccine development.

298 his perspective review is to illustrate in a rational way the current state-of-the-art in the field o

299 Cushman argues that "rationalization is rational." We show that there is reasonable empirical cl

300 stance to heat-related illness amongst their rationales when advising owners on breed selection.