ライフサイエンスコーパス: rationally

1 dominate in nature has allowed us to design rationally a well-defined and hyperstable antiparallel c

2 Ms, which is the necessary first step toward rationally achieving higher magnetic blocking temperatur

3 t how they are silenced, and how they may be rationally activated are areas of ongoing investigation.

4 s harboring dirigent-like domains can now be rationally and systematically identified.

5 t beliefs about others' behaviors are formed rationally and therefore, independently from preferences

6 ere formulated around a polymeric shell in a rationally arranged fashion with a surface glycoprotein

7 In the search for rationally assembled functional materials, superatomic c

8 hose active electrode materials can be tuned rationally, at the molecular level.

9 ses lacking NSs is an attractive strategy to rationally attenuate bunyaviruses.

10 assage and the need to develop mechanisms to rationally attenuate IBV for the next generation of effe

11 Using these insights, we rationally change folding and assembly control for this

12 under live cell coculturing conditions with rationally chosen experimental parameters.

13 We find that two rationally chosen point mutations (His447Gln and His447A

14 Two rationally chosen point mutations cause a notable increa

15 campaigns by focusing on a limited number of rationally chosen residues.

16 provide mechanistic preclinical evidence to rationally combine GITR agonism with checkpoint blockade

17 d on functionalization of the oil phase with rationally combined sensing reagents.

18 ithin the tumor microenvironment that may be rationally combined to untangle the web of immune resist

19 ithin a specific expression context could be rationally combined together in silico to create promote

20 t noisy mental simulations of the future are rationally combined with prior beliefs.

21 Herein, we show how by rationally combining robust site-specific phosphine bioc

22 bust predictor of DLBCL outcome, and discuss rationally conceived experimental approaches to treat th

23 of controllable protein units, which can be rationally configured to three tools.

24 the donor/acceptor blend is demonstrated by rationally considering the molecular interaction and ene

25 alement and further employ this knowledge to rationally construct multitier surfaces with robust supe

26 for predicting behaviors of a system and for rationally constructing or modifying the system.

27 domains to DNA nanostructures can be used to rationally control the interface between synthetic nanos

28 ncentrated gels, acts as a stepping stone to rationally control the organization in the solid-state.

29 -morphing materials called "kinomorphs" that rationally control the shape and size of multicellular n

30 s function of silica, we provide support for rationally controlling these reaction pathways.

31 dings shed light on innovative approaches to rationally create environmentally friendly and highly ef

32 work suggests that biological systems using rationally depleted but otherwise natural translation sy

33 We aimed to define whether FMT using a rationally derived stool donor is safe in recurrent HE c

34 Herein, we rationally design a DNA-based artificial molecular signa

35 Herein, we rationally design a new In single-atom catalyst containi

36 This knowledge was subsequently applied to rationally design a second-generation inhibitor scaffold

37 To rationally design and accelerate the search for the high

38 We can now also rationally design and develop drug molecules that can ei

39 ticular coupling; (iii) suggest mutations to rationally design artificial GPCRs with new coupling pro

40 The developed model will make it possible to rationally design capillary electrophoresis-based select

41 distribution, hereby providing a strategy to rationally design carbon-supported catalysts.Control ove

42 of conductive pores with active material to rationally design composites based on local charge densi

43 nces within the epitope, and our attempts to rationally design cross-reactive trimers resulted in onl

44 Despite intense efforts to rationally design degrader molecules that co-opt CRL4s,

45 ify organisms utilizing key nutrients and to rationally design effective probiotic mixtures.

46 ic differences will allow us to identify and rationally design efficient ligases with application in

47 ization represents an attractive strategy to rationally design functional chemical probes.

48 e L protein can serve as a novel approach to rationally design genetically stable, highly attenuated,

49 ngiotensin receptor that can be exploited to rationally design GPCR-targeting drugs with greater spec

50 We used a multitarget strategy to rationally design inhibitors capable of potent inhibitio

51 and how we can advance our understanding to rationally design microbial-based therapeutics to transf

52 d structural level, with the ultimate aim to rationally design molecules to maximise the efficiency o

53 f water transport in GOAL and can be used to rationally design more effective and efficient GO membra

54 However, it is currently impossible to rationally design nanoparticles that selectively target

55 facet/morphology-property relationships and rationally design nanostructures with desired properties

56 rgy, and to use the mechanistic knowledge to rationally design new combinations that bypass drug resi

57 To rationally design new variants optimized for specific ap

58 Here, we rationally design non-canonical amino acid analogs with

59 d natural proteins' properties as well as to rationally design novel biomaterials of required mechani

60 In conclusion, a method that can rationally design peptides using knob-socket model is pr

61 pe-labeling in N-alkylated amines, we herein rationally design photocatalytic water-splitting to furn

62 there is strong interest in learning how to rationally design proteins that adopt user-defined struc

63 functions within the host environment and to rationally design selective inhibitors.

64 Herein, a practical strategy was reported to rationally design single copper atoms coordinated with b

65 cted to drive and benefit future research to rationally design surface strategies with multi-paramete

66 Any attempt to rationally design the effector to be an allosteric activ

67 We now report efforts to rationally design this construct toward either green or

68 We leveraged these strong relationships to rationally design THQ-Rosol, wherein DFT calculations in

69 infection and will inform future efforts to rationally design vaccines.

70 the structure of protein excited states and rationally design validating experiments.

71 ion in their nanopores is still desirable to rationally design zeolite-based materials with tailored

72 Finally, we rationally designed a capsid that exhibits improved spec

73 hly expressed on glioma-associated TAMCs, we rationally designed a lipid nanoparticle (LNP) formulati

74 In this work, we rationally designed a new series of 4-methylquinazoline

75 We have semi-rationally designed a series of seven-residue peptides t

76 R-loop assay was used to screen a series of rationally designed A3Bctd-BE3 variants for improved spe

77 Here we report a rationally designed adeno-associated virus (AAV) 6 capsi

78 ntagonists, which are supported by a pair of rationally designed agonist and antagonist.

79 Herein, we report a rationally designed amide-based electrolyte based on the

80 an atoxic derivative (ad) of BoNT/C1 through rationally designed amino acid substitutions in the meta

81 e chemicals, and nanoparticle coating with a rationally designed and conserved guiding peptide target

82 ning cationic polyelectrolyte (PE1) has been rationally designed and developed via a facile click-che

83 mposition (MAPb0.5 Sn0.5 (I0.8 Br0.2 )3 ) is rationally designed and developed, which possesses lower

84 n PDMS by dispersing ferrofluid droplets and rationally designed and printed a rudimentary magnetical

85 (N,N'-diphenyl-p-phenyelendiamine) has been rationally designed and successfully synthesized.

86 quinazolin-4-one based hydroxamic acids was rationally designed and synthesized as novel dual PI3K/H

87 emistry and aggregation-induced emission was rationally designed and tested.

88 tal structure of human CB2 in complex with a rationally designed antagonist, AM10257, at 2.8 angstrom

89 sms of (auto-/allo-)immune diseases and more rationally designed antibody-based drugs.

90 Herein, we demonstrate that rationally designed aqueous electrolytes with high salt

91 ing excellent antifouling properties using a rationally designed artificial channel-array in a natura

92 within a flexible polymer binder matrix, the rationally designed artificial SEI not only mechanically

93 y, and adjuvanticity of an antigen have been rationally designed at the atomic level and incorporated

94 Rationally designed AuNPs could greatly benefit their an

95 targeting beta2c or beta2i could not yet be rationally designed because of the high structural simil

96 Here, we report a rationally designed bifunctional molecule, piperazinium

97 r work reveals a very effective way of using rationally designed bifunctional molecules to simultaneo

98 e potential to unlock a combinatorial set of rationally designed biological responses.

99 -coated SnO2 were crafted by capitalizing on rationally designed bottlebrush-like hydroxypropyl cellu

100 rogen peroxide and that their motions can be rationally designed by controlling particle shape.

101 k demonstrates that novel RNA modules can be rationally designed by taking advantage of the modular s

102 Here, rationally designed capping peptides control the length

103 Here, we rationally designed chitosan-complexed single-walled car

104 Patterning of photonic crystals to generate rationally designed color-responsive materials has drawn

105 e insights could be useful in developing new rationally designed combination therapies with sorafenib

106 single agent; therefore, there is a need for rationally designed combination therapies.

107 raphene-based functional nanocomposites with rationally designed compositions and architectures for p

108 of free alpha-l-arabinofuranose and several rationally designed covalent alpha-l-arabinofuranosidase

109 state of affairs on naturally occurring and rationally designed cyclic tetrapeptides, including stra

110 fficacy of the D-enantiomeric peptide RD2, a rationally designed derivative of the previously describ

111 ntally through a luminescent nanosystem with rationally designed dielectric claddings.

112 Biochemical circuits made of rationally designed DNA molecules are proofs of concept

113 ASFV-G-Delta9GL/DeltaUK is the first rationally designed experimental ASFV vaccine that prote

114 in 2D perovskite films and paves the way for rationally designed film fabrication techniques.

115 ntained variable linker length while one was rationally designed for optimizing protein-protein inter

116 hemical space, a universal NMR experiment, a rationally designed fragment library, and a sample compo

117 4-, and 6-fold rotational symmetries can be rationally designed from certain systems by tuning the m

118 HA polymers are rationally designed from relatively low-molecular-weight

119 Such rationally designed heterostructures exhibit interesting

120 thod described here could form the basis for rationally designed immunotherapy strategies to combat A

121 Vaccines need to be rationally designed in order be delivered to the immune

122 This common mechanism open avenues for rationally designed inhibitors of all MbetaLs, notwithst

123 et al., 2019) and CB2 in complex with a new rationally designed inverse agonist (Li et al., 2019) pr

124 and unactivated aryl boronic esters using a rationally designed iron-based catalyst supported by bet

125 overed by screening a chemically diverse and rationally designed library of anti-miR-17 oligonucleoti

126 tal synthesis and biological evaluation of a rationally designed library of simplified analogs that u

127 Methods: Five rationally designed low-molecular-weight ligands (L1-L5)

128 h yield ( 75%) via efficient ring closing of rationally designed metallosupramolecular polymers.

129 s, defect-free separation membrane through a rationally designed method.

130 The rationally designed MgB2/SN2 cooling system was first co

131 The rationally designed mimic engages vFLIP directly causing

132 Herein, we report on a family of rationally designed Mn-doped cobalt ferrite (MCF) spinel

133 In summary, AggFluor is the first set of rationally designed molecular rotor fluorophores that ev

134 Rationally designed N, S co-doped graphitic sheets with

135 In conclusion, we show that rationally designed nanobiologics can promote trained im

136 troy tumors through photothermal therapy and rationally designed nanostructures to circumvent cancer

137 Here, we present a suite of rationally designed NCT systems, where multiple types of

138 ginal supramolecular architecture based on a rationally designed new nanohybrid with enhanced peroxid

139 t electrons and holes from Ni to TiO(2) in a rationally designed Ni-TiO(2) heterostructure.

140 Potential applications of rationally designed oligo- and polyphosphodiesters resid

141 A rationally designed pH-activatable fluorescent probe (pH

142 Pursuit of improved, rationally designed pharmacological treatments for BD, a

143 e STING-activating nanoparticles (STING-NPs)-rationally designed polymersomes for enhanced cytosolic

144 In the present study, we develop a panel of rationally designed PPARdelta agonists.

145 Although many rationally designed proteins end up being thermostable,

146 Three rationally designed pyrrolobenzodiazepine (PBD) drug-lin

147 atalyst turnover numbers were analyzed using rationally designed reaction environments compatible wit

148 alkyl carboxylic acids respectively with two rationally designed reaction pathways.

149 Here, we report a rationally designed redox-active Au(I) bis-N-heterocycli

150 ceptors and further demonstrate the power of rationally designed selection strategies for isolating c

151 the tetrahydrofolate (THF) riboswitch using rationally designed self-assembling tectoRNAs.

152 nome-editing strategy is reported based on a rationally designed semiconducting polymer brush (SPPF).

153 In this study, we rationally designed several vaccine immunogens based on

154 Using rationally designed short peptide sequences, we determin

155 ribe the characterization and discovery of a rationally designed small molecule ZCM-I-1 as a selectiv

156 Using this method, we synthesized rationally designed stereopure components of mipomersen,

157 substantially changed TrmA* specificity, the rationally designed substrate mutants we developed still

158 In light of this, there is much interest in rationally designed subunit vaccines that direct the ant

159 th highlights including the application of a rationally designed sulfinamide chiral auxiliary, an eff

160 e accomplished through the controlled and/or rationally designed synthesis of materials with higher a

161 ble access to natural product CTPs and their rationally designed synthetic analogues having novel mol

162 investigate the mode-of-action of the small, rationally designed synthetic antifungal peptide PAF26 u

163 ate the safety and efficiency of Anc80L65, a rationally designed synthetic vector, for transgene deli

164 enetic etiology of the disease and proposing rationally designed therapeutic interventions.

165 erogeneity in patient outcome and a need for rationally designed therapeutic strategies that target d

166 tory state alterations drives discovery of a rationally designed therapeutic strategy.

167 Trastuzumab is a successful, rationally designed therapy that provides significant cl

168 ion can serve as a powerful strategy towards rationally designed thermoelectric polymers with state-o

169 ature, artificial composite materials can be rationally designed to achieve this anisotropic behavior

170 only at low pH; and MelP5_Delta6, which was rationally designed to be active at low pH but formed on

171 3, and dihydro-4-thiopyranone 13, which were rationally designed to boost the rate of enzyme inactiva

172 r discuss how such DNA nanostructures can be rationally designed to efficiently enter plant cells and

173 Unnatural sugars can be either rationally designed to enable preferential labelling of

174 ful tool to create therapeutics which can be rationally designed to enable unique and combinatorial f

175 and illustrate how drug combinations can be rationally designed to limit the resistance evolution of

176 uirements, where ionomer chemistry should be rationally designed to match the local transport require

177 t a mitochondrial chemical probe, named RCN, rationally designed to monitor osmotic effects during tr

178 y for the examination of synthetic analogues rationally designed to not only overcome vancomycin resi

179 Collections of DNA sequences can be rationally designed to self-assemble into predictable th

180 (3) Sn) intermetallic coating layer (ICL) is rationally designed to stabilize Sn through a structural

181 s in cells and in vitro, and expression of a rationally designed tubulin mutant with a mutation in th

182 Here we show that they can be rationally designed using familiar cis-3WJ examples as a

183 t high anti-stalk titres can be induced by a rationally designed vaccine in humans and opens up avenu

184 We describe the first rationally designed viroporin inhibitor with a comprehen

185 hexylcarbazole derivative named BoCz-Lip was rationally designed while achieving specific LDs live-ce

186 ssion luminogen (AIEgen), namely DPA-SCP, is rationally designed with alpha-cyanostilbene as a simple

187 ion dependence of the ligand response of the rationally designed, artificial theophylline riboswitch

188 Herein, we describe a series of rationally designed, conformationally constrained, benza

189 gical and behavioral analyses confirmed that rationally designed, genetically targeted assembly of fu

190 intensity and resonant line shape can all be rationally designed, providing a foundation for efficien

191 e- and QSAR-based drug design strategies, we rationally designed, synthesized, and biologically evalu

192 tane-1-carboxylic acid (1), in this work, we rationally designed, synthesized, and evaluated a novel

193 Here we rationally designed, synthesized, and tested a series of

194 response will help inform the development of rationally-designed live-attenuated vaccines and antivir

195 cardiac myocyte viability using SAMbetaA, a rationally-designed peptide that selectively antagonizes

196 ementary AAV-based gene therapies constitute rationally-designed strategies for a new translational m

197 Rationally designing and engineering the coordination en

198 This work is anticipated to spur rationally designing efficient earth-abundant transition

199 Rationally designing morphologic features of M-N-C catal

200 o the creation of novel ordered materials by rationally designing particle shape based on anticipated

201 scern fundamental molecular requirements for rationally designing porous molecular solids.

202 er mechanisms, (2) new design principles for rationally designing PTM systems for a variety of behavi

203 res" have implications for understanding and rationally designing pumps for the generation of proton-

204 for comprehensive transcriptome profiling by rationally designing RNA-seq adapters that minimize adap

205 nsport in superlattices and the prospects of rationally designing thermal systems with tailored phono

206 ification of these networks is important for rationally designing vaccines which can effectively bloc

207 To address these challenges, we rationally developed a drug-free human serum albumin (HS

208 We anticipate that XL413 and other such rationally developed inhibitors will be useful tools for

209 MDs, which can be identified by screening or rationally developed on the basis of the structure or se

210 The effective deployment of rationally developed therapies for diffuse large B cell

211 or understanding tolerance induction and for rationally developing novel strategies to improve patien

212 activity of GS-6207 and provide a means for rationally developing second-generation therapies.

213 of enantiopure synthetic molecular systems, rationally dictating the assembly of mixtures of enantio

214 intense interest, since such a mapping could rationally direct experiments to optimize antibiotic eff

215 theme is exploiting biomaterial features to rationally direct how specific immune cells or organs en

216 tion and treatment of obesity should be more rationally directed to the complex and often redundant m

217 ind to our knowledge, which was developed by rationally dissecting the structural requirements for TL

218 nvironmental dependencies hinders efforts to rationally engineer beneficial consortia.

219 Herein we describe a general methodology to rationally engineer cysteine-less proteins.

220 Our findings can be used to rationally engineer iRFP variants with enhanced FQYs.

221 further show that structures can be used to rationally engineer receptors with novel specificities o

222 central metabolism is extremely difficult to rationally engineer.

223 To address this, here, we rationally engineered a next-generation quadricolor GECI

224 Particularly, for AAV serotype 9 and a rationally engineered AAV variant, we demonstrate that i

225 DET) type lactate sensor was developed using rationally engineered Aerococcus viridans LOx (AvLOx) mo

226 Rationally engineered insect DHPAAS produces (R,S)-THP i

227 Here, we report rationally engineered peptide-targeted liposomal doxorub

228 To test this possibility, we rationally engineered QUAD opsin by tryptophan substitut

229 Here, to address this issue, we rationally engineered the amino acid sequence of the hig

230 ary, whose affinity and cooperativity can be rationally engineered.

231 providing a robust microfluidic platform for rationally engineering 2D autonomous flows.

232 rts and insights gained should be useful for rationally engineering gene-regulatory networks and for

233 interactions point to specific clues toward rationally engineering new generations of Cas9 systems a

234 Here, we rationally engraft a new paratope, i.e., the extended he

235 By rationally exploiting reaction conditions, the alkene st

236 of ENAH EVH1 in complex with inhibitors and rationally extended our library of conformationally defi

237 tion energies offer a non-empirical route to rationally extract reduced reaction networks for detaile

238 carboxyl functionalizations (CSD-PLNPs) were rationally fabricated.

239 onstrating that cluster architectures can be rationally formed using components with programmable val

240 nts the first steps toward the evaluation of rationally formulated drug-adjuvant combinations for in

241 The quinoline oligoamides were rationally functionalized by electron-donating and elect

242 ample, we establish that twin defects can be rationally generated by equilibrating nanoparticles of d

243 ce and structure motifs that may be used for rationally guided design.

244 etinopathy that will further guide us toward rationally-guided new therapies: synergistic combination

245 Our MCT analysis allows us to rationally identify the microstructural origin of the fr

246 ctural genomics data sets can be employed to rationally identify therapeutic vulnerabilities in self-

247 ical functionalities have been carefully and rationally implanted into the coordination nanospace of

248 rtunities for utilizing these connections to rationally improve catalytic processes involving hydride

249 Here, we rationally improve the photophysical characteristics of

250 xylates, the first reported RGGT inhibitors, rationally improve understanding of their structure-acti

251 ansition series and how these structures can rationally inform reactivity studies.

252 variants and test an unprecedented number of rationally integrated bacterial chromosomal protein expr

253 and construction of different modules into a rationally integrated system that mimics the cascade of

254 replaceable ligands, inherently provide for rationally introducing finely tuned and quantitatively p

255 compared against logic, often turn out to be rationally justified when seen in the richer rational fr

256 Overall, application of TG can rationally modify the functionality and digestibility of

257 he binding reaction coordinate are needed to rationally modulate the lifetime of the drug-target comp

258 oach represents a very versatile strategy to rationally modulate the pK(a) of synthetic devices in a

259 changes in nanoscale geometry can be used to rationally modulate the thermodynamics of individual mol

260 ar mechanism at DAT that may be leveraged to rationally optimize leads for the treatment of cocaine u

261 Their performance can be rationally optimized by tailoring the metal atoms, adjac

262 designed direct-current TENG (MDC-TENG) with rationally patterned electrode structure is presented to

263 he site-selectivity for lactonization can be rationally predicted on the basis of simple C-H activati

264 trimers can be limited by the difficulty of rationally predicting beneficial mutations, here we used

265 We present a strategy to rationally prepare CF3(-) transfer reagents at ambient t

266 The ability to rationally program molecular multivalency via a systems-

267 ra of advances have provided a framework for rationally purifying, describing, and manipulating macro

268 d to complement the others substantively and rationally, rather than modestly and empirically.

269 erstanding of the mechanism paves the way to rationally re-designed 8-aminoquinolines with improved p

270 quantitative phase diagram is constructed to rationally select parameters for the new strategy.

271 By introducing rationally selected combinations of folding-enhancing mu

272 These viral protein antigens (Ags) were rationally selected for their ability to recall strong C

273 By examining cell signaling on this map, we rationally selected ibrutinib, a BTK and ITK inhibitor,

274 ulation with an oncolytic virus expressing a rationally selected ligand can be an effective strategy

275 Attaching two pdDronpa domains at rationally selected locations in the kinase domain, we c

276 hes by insertion of a calmodulin domain into rationally selected sites.

277 pies to those that are now more targeted and rationally selected.

278 le cyanobacterial Sfp-type PPTases that were rationally selected.

279 ming, we demonstrate that a single dose of a rationally-selected dual inhibitor combination consistin

280 The system is then rebuilt by rationally selecting parts that implement the optimal ex

281 method for metal-compound guest synthesis by rationally selecting reaction agents and conditions.

282 By rationally selecting representative biological and chemi

283 a consequence, many studies have focused on rationally shaping these materials to influence and enha

284 Here, we developed CIT by rationally splitting FRB and FKBP.

285 y an important role regarding our ability to rationally synthesize atomically precise low-dimensional

286 block-poly(3,4-ethylenedioxythiophene)] were rationally synthesized and exploited as nanoreactors for

287 he recombination processes could allow us to rationally tailor the properties of these fascinating se

288 By rationally tailoring the molecular structure of azobenze

289 acid as an optimal amino acid derivative to rationally target the proline-dependency of tumour growt

290 accelerate therapeutic research, leading to rationally targeted approaches that may ultimately impro

291 on compartments is fundamental to developing rationally targeted repair strategies.

292 behavioral data by assuming an agent behaves rationally-that is, it takes actions that optimize its s

293 ion binding ability of which can be modified rationally through selective post-assembly functionaliza

294 The space was created rationally through templated polymerization within cross

295 In this work, we have rationally truncated an aptamer capable of recognizing g

296 so show that the S(1)-T(1) energy gap can be rationally tuned by introducing N atoms into the aromati

297 of coarse-grained simulations as a tool for rationally tuning and optimizing RNA folding and functio

298 ng, identifying simple design principles for rationally tuning the dose response.

299 nt because they provide a starting point for rationally tuning the thermodynamics of catalytic interm

300 state and their molecular packing models are rationally understood.