ライフサイエンスコーパス: reaction intermediate

1 tion and without the formation of a covalent reaction intermediate.

2 n the active site, thus mimicking an achiral reaction intermediate.

3 2.1.0(2,4)]oct-8-ylidene is a foiled carbene reaction intermediate.

4 gh the identification of ketene (CH2CO) as a reaction intermediate.

5 appearing as a band shoulder) arising from a reaction intermediate.

6 e level, which revealed a long-lived (4.5-s) reaction intermediate.

7 e, generating a vinyl radical as a potential reaction intermediate.

8 (II)alamin rather than cob(I)alamin is a key reaction intermediate.

9 es through differential stabilization of the reaction intermediate.

10 nts that it is not an energetically feasible reaction intermediate.

11 lpha position followed by isomerization of a reaction intermediate.

12 ered nicks invariably at 6-bp spacing as the reaction intermediate.

13 vironment of the [2Fe-2S](+) cluster in this reaction intermediate.

14 tance of protonated carbonic acid (PCA) as a reaction intermediate.

15 6-TG, suggesting that G(SO3) is an important reaction intermediate.

16 lly assigned the hyperfine interactions in a reaction intermediate.

17 site hydrogen bonds donated to the dienolate reaction intermediate.

18 eals the structure of the proposed thioester reaction intermediate.

19 ect scattering dynamics through a long-lived reaction intermediate.

20 similar to the measured pK(a) (10.0) of the reaction intermediate.

21 of a dizinc metallo-beta-lactamase (MbetaL) reaction intermediate.

22 was synthesized as a model compound for the reaction intermediate.

23 formyl-coenzyme A (formyl-CoA) as a central reaction intermediate.

24 presumably generates a key ferryl (Fe(IV)=O) reaction intermediate.

25 carboxyl radical confirm its formation as a reaction intermediate.

26 d substrate to form the enediolate phosphate reaction intermediate.

27 ed tetraiodide radical anion (I4(*)(-)) as a reaction intermediate.

28 m, which entails the characterization of the reaction intermediates.

29 characterized, isolated, or hypothesized as reaction intermediates.

30 active iron-nitrosyl adduct, a surrogate for reaction intermediates.

31 conversion of amino acids includes numerous reaction intermediates.

32 e O2 bond and then will proceed to over-bind reaction intermediates.

33 the dNTP, suggesting its role in stabilizing reaction intermediates.

34 ms that derives from characterization of key reaction intermediates.

35 due to difficulties in identifying distinct reaction intermediates.

36 rves as a template for identification of the reaction intermediates.

37 reactions in real time and identify unstable reaction intermediates.

38 6F5 groups reduces the binding energy of all reaction intermediates.

39 information is not available for any of the reaction intermediates.

40 g carbannulation of in situ generated Blaise reaction intermediates.

41 ves organogold complexes as precatalysts and reaction intermediates.

42 saturated 16- and 17-electron organometallic reaction intermediates.

43 into its reactions with commonly encountered reaction intermediates.

44 s, never isolated but eventually proposed as reaction intermediates.

45 h Lewis acid catalyzed benzene alkylation by reaction intermediates.

46 nment towards optimal adsorption behavior of reaction intermediates.

47 or to elucidate the structures of the labile reaction intermediates.

48 powerful tool for the investigation of ionic reaction intermediates.

49 between D309 and the substrate to stabilize reaction intermediates.

50 fects on the cluster properties and possible reaction intermediates.

51 d on direct evidence of the in-situ-captured reaction intermediates.

52 d and that gold carbenes are not involved as reaction intermediates.

53 ginine and NOHA oxidation reactions and trap reaction intermediates.

54 ce that uses positively charged reagents and reaction intermediates.

55 and facilitates the adsorption/desorption of reaction intermediates.

56 e Rh surface enhances hydrogenation rates of reaction intermediates.

57 e mostly encountered as short-lived reactive reaction intermediates.

58 s with ADP-BeF(x) that capture two potential reaction intermediates.

59 nd formation among weakly adsorbed water and reaction intermediates.

60 with formation of squaramates as detectable reaction intermediates.

61 tathione sulphinic acid, and GSSG are rather reaction intermediates.

62 N-DBPs formation mechanisms and to identify reaction intermediates.

63 The hyperpolarized reaction intermediate 2-hydroperoxy-2-hydroxypropanoate

64 rized as a result of this study, including a reaction intermediate, 2 Schiff bases, and 28 bis- or tr

65 ructure of CYP11A1 in complex with the first reaction intermediate, 22HC.

66 767A PlGoxA revealed a previously undetected reaction intermediate, a carbinolamine product-reduced C

67 the oxidation rate is enhanced and a unique reaction intermediate accumulates.

68 and the cross-aldol condensation between the reaction intermediates acetaldehyde and acetone.

69 ructures of the reaction product and several reaction intermediates agree well with the relevant crys

70 The observation of individual reaction intermediates allows the measurement of an isot

71 For R = MeSO2 and CF3SO2, the corresponding reaction intermediates, amidoaryl Pd(IV) complexes were

72 nsity at the active site appropriate for the reaction intermediate aminoacrylate, which is consistent

73 RNA synthetase is through the aminoacylation reaction intermediate aminoacyl-AMP, thus making Ap4A sy

74 ide the first direct evidence for an elusive reaction intermediate and characterize the most complete

75 Although the first reaction intermediate and its decay are not affected by

76 the closure of the lid domain stabilizes the reaction intermediate and protects the reactive intermed

77 nserved cysteine residue of the protein to a reaction intermediate and the demonstration that THI4p i

78 ing to the unambiguous identification of one reaction intermediate and two reaction products.

79 vide structural evidence of several proposed reaction intermediates and allow for a more complete und

80 hanistic investigations provide insight into reaction intermediates and allow the development of a mi

81 -coupling reactions involving organometallic reaction intermediates and catalysis by Lewis acid sites

82 study clearly demonstrates the migration of reaction intermediates and catalyst material across surf

83 ontrol the timing of interaction between the reaction intermediates and catalytically essential amino

84 (HAMs) and haloacetic acids (HAAs) as major reaction intermediates and end products.

85 nic acid complexes represent a "snapshot" of reaction intermediates and implicate the cysteine-sulfen

86 que insights into the chemical nature of the reaction intermediates and into their role in determinin

87 xtract rate constants for the degradation of reaction intermediates and investigate the effects of va

88 s, as established by preparation of putative reaction intermediates and mass spectrometric analysis.

89 Insight into the nature of transient reaction intermediates and mechanistic pathways involved

90 Computational chemistry research into reaction intermediates and pathways may further aid in u

91 t via a hydrogen network that stabilizes the reaction intermediates and possibly shuttles protons.

92 , which reveal remarkable differences in the reaction intermediates and products expected in sea spra

93 Reaction intermediates and products were subsequently an

94 ted trends in activity and the nature of the reaction intermediates and products.

95 s isomer-specific vibrational spectra of the reaction intermediates and products.

96 inetic modeling is used to identify critical reaction intermediates and rate-determining elementary r

97 its suitable adsorption energies to some key reaction intermediates and reaction kinetics in the HER

98 tification of influential parameters and key reaction intermediates and reactions.

99 reported mechanistic proposal relies on two reaction intermediates and requires further investigatio

100 uted to both the stabilization of protonated reaction intermediates and the effect of constrictive bi

101 and the rate-determining steps based on the reaction intermediates and their binding energies are an

102 , an approach that destabilizes the ethylene reaction intermediates and thereby promotes ethanol prod

103 trosynthesis reaction in order to reveal the reaction intermediates and to shed light into the reacti

104 Furthermore, hypothetical reaction intermediates and transition structures were an

105 hese mechanisms requires characterization of reaction intermediates and, in particular, snapshots of

106 by cations, (3) non-uniform distribution of reaction intermediates, and (4) non-selective chemistry

107 bon-halogen bond cleavage, identification of reaction intermediates, and elucidation of mechanisms).

108 The reaction mechanism, reaction intermediates, and final degradation products w

109 of benzynes and nonclassical carbocations as reaction intermediates, and he was instrumental in estab

110 ites, transition-metal-ion oxidation states, reaction intermediates, and lattice-oxygen-stabilization

111 Reagents, catalysts, reaction intermediates, and products involved in the oxy

112 e and product binding and release, sequester reaction intermediates, and recruit catalytic groups.

113 entary characterization of adsorbed species, reaction intermediates, and structural properties of the

114 uperoxo and ferric hydroperoxide species are reaction intermediates, and the lysine 48 plays a key ro

115 mplex of eIF2B with its substrate, eIF2-GDP, reaction intermediates, apo-eIF2 and eIF2-GTP, and produ

116 poses a major challenge since the essential reaction intermediates are collective, diffusive and of

117 alysts through direct observation of surface reaction intermediates are discussed.

118 These reaction intermediates are easily produced in situ and c

119 enzymatic nucleophile and that the proposed reaction intermediates are not covalently bound to the e

120 the transition state and the binding site of reaction intermediates are often decoupled, which can en

121 The unusual spiroepoxide and vinylether reaction intermediates are precursors to the final bicyc

122 studies showed that K(+)- and Rb(+)-occluded reaction intermediates are similar.

123 We investigate how key CO reduction reaction intermediates are stabilized in different elect

124 ron biosynthetic reaction is determined, and reaction intermediates are structurally characterized.

125 action is also explored; E/Z geometry of the reaction intermediate as well as the presence of catalyt

126 ethod exhibit different oxidation states and reaction intermediates as well as electrocatalytic prope

127 cleft as well as selective stabilization of reaction intermediates at the scissile alkene.

128 ndo mass spectrometry struggles in detecting reaction intermediates because the batch-type electroche

129 time that at certain concentrations of DBU, reaction intermediates become stabilized, an effect that

130 In contrast, the reaction intermediate beta-glucose 1,6-bisphosphate, who

131 onodisperse Au NPs to optimize the available reaction intermediate binding sites for efficient and se

132 ent structures of OOR in which two different reaction intermediate bound states have been trapped: th

133 ant (10(5 +/- 2.5) M(-1) s(-1)), forming the reaction intermediate (BrNO)(SO2)N(CH3)2(-).

134 Engineered DNA substrates that stabilize a reaction intermediate by mimicking a "flipped-out" confo

135 rmed from ionic Cu in solution via catalytic reaction intermediated by reduced Cu(I) species.

136 mited spectrophotometric characterization of reaction intermediates by masking the absorption of the

137 different conditions and identifying several reaction intermediates by NMR spectroscopy, mass spectro

138 eover, on the basis of the identification of reaction intermediates by stoichiometric reactions and N

139 (T)/6-31+G(d) level should be used for these reaction intermediates; CCSD(T)/6-31+G(d) and CCSD(T)/6-

140 es is transiently dephosphorylated while the reaction intermediate completes a 180 degrees reorientat

141 es reported by Rebek et al. in which elusive reaction intermediates could be detected in the inner ca

142 ibility facilitates the reorientation of the reaction intermediate, coupling changes in structural dy

143 e) pathway is shut down, so that instead the reaction intermediate diverts through the alternative (h

144 In situ trapping of the reaction intermediates (DNA-TFAM cross-links) revealed t

145 oexistence of CO(atop) and CO(bridge) as the reaction intermediates during CO(2) reduction and that t

146 n of the DNA can be used to reveal transient reaction intermediates during transcription initiation b

147 m the energetically favourable adsorption of reaction intermediates, endowed by the unique heterophas

148 an important reagent ion as well as the key reaction intermediate for the formation of other reagent

149 reviously anticipated and suggest a possible reaction intermediate for thioether bond formation.

150 within MoFeP and the population of discrete reaction intermediates for structural investigations.

151 SAXS measurements show that the reaction intermediate formed at 100 degrees C presents a

152 of the adjacent framework, and the specific reaction intermediate formed is very sensitive to this f

153 ce stopped-flow spectroscopy to characterize reaction intermediates formed under catalytic turnover c

154 MBPP to an (unreactive) E126A IspH mutant, a reaction intermediate forms that has a very similar EPR

155 Two other plausible reaction intermediates, [Fp(t-BuPA)][BF(4)] and [Fp(1-t-

156 y (DFT) calculations reveal the evolution of reaction intermediates from a methoxy CH(3)-O-Fe, to a b

157 e max) CAS and OASS form alpha-aminoacrylate reaction intermediates from Cys and O-acetylserine, resp

158 PS5, (2Z,6E)-FDP, an analogue of presumptive reaction intermediates from natural reaction cascade, wa

159 transition state is bimodal, leading to two reaction intermediates from one transition state, which

160 of local structure in homogeneous amorphous reaction intermediates from techniques such as PDF can b

161 ider range of process-related impurities and reaction intermediates from the PEG-maleimide polymers t

162 spectroscopy to detect and characterize HydG reaction intermediates generated with a set of (2)H, (13

163 Recently, in crystallo reaction intermediates have elucidated how hExo1 exerts

164 larifying the debate on the nature of such a reaction intermediate in glycoside hydrolases operating

165 It has been proposed to be a reaction intermediate in several chemical reactions and

166 it has been proposed that 5hmC may only be a reaction intermediate in the process of demethylation.

167 e consistent with a structural model for the reaction intermediate in which 9-mercaptodethiobiotin is

168 the mass spectrometric detection of fleeting reaction intermediates in electrochemical reactions util

169 Here, we report on the investigation of the reaction intermediates in high temperature syntheses of

170 , we have characterized and assigned two key reaction intermediates in IspH catalysis.

171 ixation and to spectroscopically capture the reaction intermediates in its catalytic cycle.

172 They have also been proposed as reaction intermediates in numerous catalytic processes (

173 ugh endoperoxides have been suggested as key reaction intermediates in several cases, the only well-c

174 e enzymatic reaction detected no accumulated reaction intermediates in solution, suggesting that rear

175 mutation facilitates the detection of closed reaction intermediates in the activation pathway of glyc

176 nal high-valent metal-oxygen species are key reaction intermediates in the catalytic cycle of both en

177 a result of prolonging the residence time of reaction intermediates in the hydrophilic microenvironme

178 tection to provide structural information on reaction intermediates in the photochemical reduction of

179 (2))(n)(-) ions are trapped entrance channel reaction intermediates in which the charge remains local

180 (DCMTases) catalyze cytosine methylation via reaction intermediates in which the DNA is drastically r

181 Rather, the enhanced presence of reaction intermediates in which Top2 is clamped around D

182 distribution of the free energy cost to form reaction intermediates, in analogy with metal-oxide cata

183 The detection by mass spectroscopy of the reaction intermediates, in conjunction with the results

184 too high, hence rendering the corresponding reaction intermediates inaccessible.

185 ave detected previously proposed short-lived reaction intermediates, including two nitrenoid complexe

186 It is characterized by the channeling of the reaction intermediate indole and the mutual activation o

187 Diffraction simulations indicate that the reaction intermediate involved on picosecond times may n

188 electron source for the reaction and that a reaction intermediate is bound directly to the cluster.

189 The chemically modified reaction intermediate is consistent with currently propo

190 The cleavage reaction intermediate is exploited by cytotoxic agents,

191 e lid, the enzyme's ability to stabilize the reaction intermediate is weakened, resulting in catalyti

192 ow procedure involving minimal processing of reaction intermediates is also reported.

193 d hydrogen peroxide without stabilization of reaction intermediates is consistent with the data prese

194 for this link involves short-lived chemical reaction intermediates known as radical pairs.

195 he sulfide source, we were able to observe a reaction intermediate (lambda(max) = 473 nm), which we a

196 The formation of oxetane, the reaction intermediate leading to (6-4) adducts, occurs v

197 f a fluorescent analog (coumarin 183) of the reaction intermediate mimics the change in charge distri

198 pectrometry is a powerful technique to probe reaction intermediates near the surface of catalyst in e

199 odulating catalysis and implicates three new reaction intermediates; Nia-I, Nia-D, and Nia-SR(-).

200 tional findings suggest the existence of new reaction intermediates not covalently bound to TSase, wh

201 In addition, we proposed that the first reaction intermediate observed by pulse radiolysis is a

202 The two paramagnetic reaction intermediates observed correspond to the two in

203 Furthermore, we provide evidence for the reaction intermediate of PopP2-mediated acetylation, an

204 Thus, the crystal structure emulates a reaction intermediate of the first nucleophilic attack d

205 we determined the crystal structures of two reaction intermediates of a marine bacterial Tmm (RnTmm)

206 conditions were used to identify the initial reaction intermediates of CdS quantum dot (QD):MoFe prot

207 We validate the method by visualising reaction intermediates of early RecA filament growth acr

208 anic-coated mercury sulfide nanoparticles as reaction intermediates of heterogeneous mineral precipit

209 s for the sequestration of potentially toxic reaction intermediates of melanin synthesis and depositi

210 Observation and structural studies of reaction intermediates of proteins are challenging becau

211 t any damage at room temperature, and of the reaction intermediates of PS II during O-O bond formatio

212 15)N HMBC NMR spectroscopy to resolve scarce reaction intermediates of the non-enzymatic discoipyrrol

213 try observed is due to the topologies of the reaction intermediates of the proposed two-step mechanis

214 synthesis and characterization of potential reaction intermediates offered a glimpse of the elementa

215 suggest a potential allosteric influence of reaction intermediates on ACP binding, and vice versa.

216 idene is most likely generated as one of the reaction intermediates on the basis of both mechanistic

217 cause it has not been possible to detect the reaction intermediates on the electrode surface experime

218 ributed to the moderate adsorption energy of reaction intermediates on the mononuclear iridium ion co

219 7-cyclooctatetraenyl radical accesses exotic reaction intermediates on the triplet surface, which can

220 eveloped methodology for studying metastable reaction intermediates prepared with a high-energy molec

221 osqualene synthase (CrtM) complexed with its reaction intermediate, presqualene diphosphate (PSPP), t

222 tivity is also promoted by the fact that the reaction intermediates produced from methanol decomposit

223 EPR/HYSCORE spectra of reaction intermediate, product, and inhibitor ligands bo

224 trate and covalent pre- and post-dehydration reaction intermediates provide snapshots of successive s

225 hrough (18)O labeling and the synthesis of a reaction intermediate provides evidence for an unusual u

226 ron-carbodicarbene complex was isolated as a reaction intermediate, providing mechanistic insight int

227 duct is proposed to correspond to a derailed reaction intermediate, providing unique evidence for the

228 The latter observation suggests that a reaction intermediate reacts with oxygen to initiate the

229 Abeta self-assembly, which involves multiple reaction intermediates related by nonlinear and intercon

230 protection rate can be optimized so that all reaction intermediates remain soluble, allowing cyclodeh

231 tulated many years ago, the structure of the reaction intermediates remained elusive owing to their s

232 However, the identification of the reaction intermediates remains elusive, having negative

233 arbon and binder with discharge products and reaction intermediates, respectively.

234 The reaction intermediates [Ru(DuPHOS)(2)] and [Ru(BPE)(2)]

235 er generated by C-O bond rupture) or both as reaction intermediate(s).

236 It is possible to trap the reaction intermediate selenenic acid when the resolving

237 However, the instability and reactivity of reaction intermediate, semiquinone, might require a cofa

238 ules; this has an important influence on the reaction intermediates' stability and, therefore, in the

239 st these mechanisms via chemical trapping of reaction intermediates, stopped-flow, and substrate hydr

240 besides the expected reaction products, the reaction intermediates such as the monopyrazolylborate i

241 ed geometric factors of the substrate-enzyme reaction intermediates, such that catalysis is limited b

242 on and comprehensive characterization of the reaction intermediates support a catalysis cycle propose

243 These results help clarify the nature of the reaction intermediate, supporting a direct interaction b

244 ton affinity between the active site and the reaction intermediate supports the possibility that a sh

245 till controversy surrounding the identity of reaction intermediate that catalyzes carbon-carbon sciss

246 s at pH 7.0-8.5, and represents a metastable reaction intermediate that is converted into manganite a

247 nt kinetic stabilization of a reductive half-reaction intermediate that is detectable with the mutant

248 e binding of half-protonated semiquinone - a reaction intermediate that is potentially formed during

249 vage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by

250 a variety of small thiols to compete for the reaction intermediate that precedes the hydride transfer

251 ept-1-ylidene is a markedly strained carbene reaction intermediate that was generated by high-vacuum

252 s proposed mechanism includes three discrete reaction intermediates that are covalently bound to CTQ

253 of these reactions have identified numerous reaction intermediates that are on the pathways to final

254 wo most recently proposed mechanisms involve reaction intermediates that are unusual in pyrimidine bi

255 c C-N coupling reaction and giving access to reaction intermediates that reveal details about each st

256 reactions in crystals, we have trapped hExo1 reaction intermediates that reveal structures of these s

257 Our data identify a transient reaction intermediate, the elusive ADP.P(i) nucleotide s

258 outes involving solution chemistry and ionic reaction intermediates, the gas phase synthesis involves

259 a covalent inhibitor that mimics one of the reaction intermediates, there is an overall decrease in

260 strength between the metal ion and adsorbed reaction intermediates thereby maximizing oxygen-reducti

261 valent resolvase-DNA linkages in the natural reaction intermediate thus perform an essential DNA-teth

262 e the high energy barrier by stabilizing the reaction intermediates, thus spontaneously favoring CO(2

263 g the cyclization of the bis-quinone methide reaction intermediate to yield (+)- or (-)-pinoresinol.

264 e active site and react with a deacetylation reaction intermediate to yield an ADP-ribosylated peptid

265 e allowed the determination of structures of reaction intermediates to a resolution of 1.6 angstroms.

266 ared photodissociation spectroscopy of model reaction intermediates to applications of infrared multi

267 nases can proceed through the same principal reaction intermediates to catalyze the O2-dependent clea

268 dependent structures, each associated with a reaction intermediate; to establish the pathways and rat

269 DFT reveals that whereas SrRuO(3) binds reaction intermediates too strongly, Na doping of ~0.125

270 We then followed the reaction intermediate transitions as Holliday junctions

271 The neutral reaction intermediates undergo pinacolic rearrangements

272 tructure energy calculations of the involved reaction intermediates using ab initio theoretical metho

273 Analysis of reaction intermediates using mass spectrometry provides

274 A catalyst functions by stabilizing reaction intermediates, usually through surface adsorpti

275 The main reaction intermediate was found to be CO2(delta-), with

276 ne], which mimics the tightly bound acyl-AMP reaction intermediate, was able to effectively inhibit A

277 ze the accumulation of potentially hazardous reaction intermediates, we have also developed a continu

278 Several possible reaction intermediates were investigated, and the quater

279 Reaction intermediates were isolated, and possible pathw

280 riginate from CS2 and H2O, respectively, and reaction intermediates were observed by gas-phase and el

281 Cationic reaction intermediates were studied by means of NMR and

282 corresponding nitroso oxides, which are the reaction intermediates, were investigated by flash photo

283 n novel autoxidation products, including two reaction intermediates, were isolated and identified usi

284 finity and residue protonation show that, in reaction intermediates where an acid is ionized in BR, a

285 ism involving chloramines and chloramides as reaction intermediates, where the initial chlorination i

286 tic reaction proceeds via the formation of a reaction intermediate, which is subsequently hydrolyzed

287 oxy-1-(pyridin-2-yl)indolin-3-one as the key reaction intermediate, which undergoes a C-C bond cleava

288 a thionitrate adduct to Cys-302 as the first reaction intermediate, which was also found by mass spec

289 istic picture that involves Ni(I) as the key reaction intermediates, which are generated via compropo

290 Based on the reaction intermediates, which can be trapped at low temp

291 aromatic systems and remarkable (polycyclic) reaction intermediates, which cannot be studied via clas

292 enable identification of catalytic sites and reaction intermediates, which facilitates the comprehens

293 s impose pronounced diffusion limitations on reaction intermediates, which leads to secondary crackin

294 uncovered distinct catalytic activities and reaction intermediates, which plausibly rationalized the

295 uctures a citrate anion forms an acyl-enzyme reaction intermediate with the catalytic threonine.

296 k-field imaging, we structurally examine the reaction intermediates with 1 nm resolution.

297 ped a protocol to observe normally invisible reaction intermediates with a surface enhanced spectrosc

298 Trapping of reaction intermediates with ciprofloxacin revealed compl

299 ldehyde due to van der Waals interactions of reaction intermediates with the surface was predicted an

300 sions was studied by independently preparing reaction intermediates within model NCPs.