ライフサイエンスコーパス: readily accessible

1 g the diversity of target molecules that are readily accessible.

2 ut functionally relevant) side chains is not readily accessible.

3 major objective where antenatal care is not readily accessible.

4 d (FFPE) tissues with clinical diagnosis are readily accessible.

5 s about their use of animals in research are readily accessible.

6 shell tetrapod ZnS@CdS heterostructures were readily accessible.

7 basis and disease-relevant tissue (skin) is readily accessible.

8 to signaling network responses has not been readily accessible.

9 sufficient reference population data become readily accessible.

10 s of the 3DNA suite of command-line programs readily accessible.

11 ry electron-poor products, making these more readily accessible.

12 iopsy (TJLB), a procedure that is not always readily accessible.

13 atives of lysine, arginine and glutamine are readily accessible.

14 le one-pot synthesis of protoberberines from readily accessible 1,2,3,4-tetrahydroisoquinoline-1-carb

15 formation of the adamantanone core from the readily accessible 1,5-dimethyl-3,7-dimethylenebicyclo[3

16 ization of oxetane alcohol 17, prepared from readily accessible 2-methyleneoxetane 12, yielded epoxyt

17 Readily accessible 3-(2-aminophenyl)-5-hexenyn-3-ols und

18 addition across the exocyclic double bond of readily accessible 3-alkylidene-1,2-diazetidines.

19 Readily accessible 3-aryl-2-carboxypropenones (by Knoeve

20 d whole blood aggregometry assay, based on a readily accessible 96-well plate format coupled with qua

21 Here, we describe a readily accessible AAAA-DDDD quadruple hydrogen-bonding

22 This site is located where it is readily accessible above the VSG layer.

23 mine antioxidants enables the preparation of readily accessible, air-stable analogues, several of whi

24 tion of heteroaryl nucleophiles to a simple, readily-accessible alkyl sulfinyl (IV) chloride allows f

25 ch are prepared through click chemistry from readily accessible alkynes and sulfonyl azides.

26 that allow for additions of alkenyl units to readily accessible allylic electrophiles is disclosed.

27 amino esters via nucleophilic allylation of readily accessible alpha-chloro glycinates.

28 of a catalyst that is derived in situ from a readily accessible aminophenol compound at ambient tempe

29 dative homocoupling of benzophenone imine, a readily accessible ammonia surrogate.

30 A membrane based on 30 m(2) of graphene, a readily accessible amount, could provide a heavy-water o

31 2.1.1.67) as model enzymes, this robust and readily accessible analogue displays kinetic parameters

32 eb site to make these global expression data readily accessible and amenable to complex search strate

33 ally active carboxylic acid derivatives from readily accessible and commercially available starting m

34 tive tissue target for vaccination, as it is readily accessible and contains a dense population of an

35 Readily accessible and easy-to-handle Ru complexes capab

36 This readily accessible and inexpensive "real-time" profiling

37 The "ate" complex (L(Li))ScR(3) is readily accessible and is best described as a Li carbene

38 of cyclopropanes and epoxides by combining a readily accessible and isolable N,N'-diamidocarbene with

39 ction, it was often used because it was more readily accessible and much less expensive than prescrip

40 Fully loaded: Readily accessible and shelf-stable 1-bismuth(III) acety

41 ive addition because of their ability to use readily accessible and stable olefins as surrogates for

42 ent-directed hospital-level metrics that are readily accessible and understood by all.

43 perimental protocols, our assembly method is readily accessible and will facilitate the construction

44 to detect vacuolated lymphocytes is a rapid, readily accessible, and sensitive screening test for JNC

45 As a mobile app, it is intuitive to use, readily accessible, and sensitive to the severity of mac

46 substituted olefin containing oxindoles from readily accessible anilides has been developed.

47 can be synthesized from copolymerization of readily accessible aryl dibromides and norbornadiene or

48 (CCRs) of aryl and heteroaryl chlorides with readily accessible aryl lithium reagents.

49 The means to utilize readily accessible aryl or vinyl ethers as counterparts

50 he presence of an air-stable Ni(II) complex, readily accessible aryl pivalates participate in the Suz

51 d circulating plasma exosomal miR-125a-3p is readily accessible as diagnosis biomarker for early-stag

52 This work provides a simple and readily accessible assay to engineer stabilized GP varia

53 We now describe an unbiased, sensitive, and readily accessible assay, referred to as high-throughput

54 calculated free energy surface, and both are readily accessible at 300 K.

55 The reaction is readily accessible at room temperature, and a computed a

56 de)-N-acetylglucosamine (lipid II), which is readily accessible at the outside of the cell and which

57 At room temperature a readily accessible bench-stable Ni(II) precatalyst is hi

58 emonstrate that synthetically unexplored but readily accessible benzothiophene S-oxides serve as nove

59 +/-)-xylopinine from two closely related and readily accessible bicyclic alpha-aminonitriles.

60 e increasingly recognized as noninvasive and readily accessible biomarker for risk stratification, di

61 ets, which has led to its extensive use as a readily accessible biomarker, under the assumption that

62 d, potentially, functional complexity within readily accessible biomimetic materials.

63 In this study, we demonstrate that the readily accessible (biphenyl-4-yl)methylammonium chlorid

64 ur results establish circulating miRNAs as a readily accessible blood biomarker to monitor disease in

65 mance of the Xpert assay as applied to other readily accessible body fluids such as exhaled breath co

66 concise and stereocontrolled manner from the readily accessible building blocks 4-6.

67 he Ugi multicomponent reaction in which four readily accessible building blocks are mixed together to

68 hosphorylated lipid A molecules that are not readily accessible by chemical methods.

69 y linked into complex molecules that are not readily accessible by classical synthetic methods.

70 N-(Aryloxy)imines, readily accessible by condensation/tautomerization of (p

71 They provide a planar geometry readily accessible by confocal fluorescence microscopy,

72 tiopure homoallylic boronates, which are not readily accessible by current methods.

73 ]pyridines, compounds that are currently not readily accessible by existing synthetic methods.

74 structurally simpler analogues that are not readily accessible by isolation.

75 opsin II intermediate (>1 ms) is beyond that readily accessible by molecular dynamics, we use NMR dis

76 irways and alveoli is highly complex; it not readily accessible by non-mathematicians.

77 -hydroxy/aryl)imino-beta-oxodithioesters are readily accessible by the reaction of beta-oxodithioeste

78 with a broad range of substrates, which are readily accessible by the Ugi reaction.

79 omoted in the presence of 2.5-7.5 mol % of a readily accessible C(1)-symmetric chiral imidazolinium s

80 the broad diversification of previously not readily accessible C4 and C5 ring positions of the 1,2-a

81 The readily accessible carboxylate groups on the material su

82 The method employs a readily accessible catalyst (NiBr(2).diglyme/4,4'-di-ter

83 S in S. aureus known, and constitute new and readily accessible chemical tools for the study of the A

84 rformed in the presence of 1.0-5.0 mol% of a readily accessible chiral accessible N-heterocyclic carb

85 A new class of readily accessible chiral amino-phosphine precatalysts d

86 We report that a readily accessible chiral carboxylic acid catalyst exert

87 The use of readily accessible chiral starting materials and lactone

88 have been prepared by the direct addition of readily accessible chlorotetrafluorosulfanyl arenes to p

89 machinery, have been hampered by the lack of readily accessible chromosomal deletions of the correspo

90 ferrocenylsilanes (PFS), a well-established, readily accessible class of main chain organosilicon met

91 thogonal chemistries in that it makes use of readily accessible, commercially available reagents and

92 phosphino)ferrocene) catalyst system and the readily accessible coupling reagent (Me4N)SCF3.

93 Overall, this paper reports readily accessible, cyanine-based through-bond ET casset

94 rapidly assembles the tetracyclic core from readily accessible cyclopentyl building blocks.

95 abeled) side chains to be added to a common, readily accessible dehydroalanine precursor in a range o

96 ta reveal that B cells represent a novel and readily accessible delivery system that can effectively

97 se spatial arrangements and patterns using a readily accessible design strategy.

98 incubation at 37 degrees C, suggesting that readily accessible divalent cation binding sites in the

99 n donor solvents, or with substrates bearing readily accessible donor sites.

100 for highly stereoselective syntheses of non-readily accessible E isomers, which normally require the

101 based on the utilization of naphthalene as a readily accessible, economically attractive, and thus fa

102 resented here makes salient features of DSSR readily accessible, either via the Java-based Jmol appli

103 ixed PCE-vegetable oil NAPL which provided a readily accessible electron donor, resulting in rapid PC

104 substituents via the functionalization of a readily accessible enantiopure lithium phosphinoamide wi

105 A base-mediated 6-endo-trig cyclization of readily accessible enone-derived alpha-amino acids has b

106 The readily accessible enones 8, 17, and 18 undergo 2-fold r

107 Human serum is a rich source of readily accessible EVs; however, the separation of EVs f

108 ynamics of magnetic solitons and establish a readily accessible experimental framework to study relat

109 s directly applicable to data acquired using readily accessible experimental methods such as Fluoresc

110 lasma ctDNA is more convenient to test, more readily accessible, faster to obtain and less invasive,

111 t by controlled reductive elimination from a readily accessible Fe precatalyst.

112 atives, synthesized through the reactions of readily accessible feedstock olefins with beta-nitrostyr

113 lex materials from commercially available or readily accessible feedstocks.

114 forward semantics and clean syntax make it a readily accessible first language; (ii) it is expressive

115 Compatible with readily accessible fluorescence microscopes, these easy-

116 precursor cells as a source of NSCs are not readily accessible for clinical application.

117 ed from the peptide-Fc fusion proteins, were readily accessible for complete separation by RP-HPLC an

118 Because extravascular fragments are not readily accessible for removal, many patients are not re

119 s are kinetically and thermodynamically more readily accessible for the Gly41Ser variant than for the

120 rsons, ongoing vision-screening programs and readily accessible free eye clinics may help address thi

121 3-Aminovinylquinoxalines are readily accessible from (hetero)aryl glyoxylic acids or

122 e projects with curated annotation, which is readily accessible from a web based resource.

123 pha-Oxy- o-xylylene, a highly reactive diene readily accessible from benzocyclobutenol, undergoes Die

124 tion for therapeutic development that is not readily accessible from currently available technology.

125 Whereas six-membered rings are readily accessible from Diels-Alder reactions, cycloaddi

126 new class of chiral 1,2-amino ether ligands, readily accessible from naturally occurring alpha-amino-

127 d compounds, and that the range of scaffolds readily accessible from nature is limited.

128 iciently synthesized from ketone 9 (which is readily accessible from the Inhoffen-Lythgoe diol) with

129 he required alkali metal salts M(2)[DBA] are readily accessible from the respective neutral DBAs and

130 Access to more readily accessible functional mimics would be highly des

131 lefin with commercially available HB(pin) or readily accessible HB(trip)(2) (pin=pinacolato, trip=2,4

132 ly selective oxidative dearomatizations of a readily accessible helicene provided a divergent route t

133 ave been limited to the highly sensitive and readily accessible hematopoietic tumors.

134 mprovements in genomics methods coupled with readily accessible high-throughput sequencing have contr

135 Readily accessible histidine-containing peptides mediate

136 oup at C3 in glucose, circumventing the more readily accessible hydroxyl at C6 and the more reactive

137 ted system that makes phylogenetic knowledge readily accessible in computable form.

138 obile camera phone--devices that have become readily accessible in developing countries--into a highl

139 ccess elusive phase transitions that are not readily accessible in equilibrium.

140 the binding constant of soluble proteins is readily accessible in experiments, our results provide a

141 e level of disorder, a parameter that is not readily accessible in mesoscopic systems.

142 These complexes are readily accessible in one step from commercially availab

143 From clinical factors readily accessible in primary care, our risk score could

144 enewable and sustainable wastewater which is readily accessible in the local environment.

145 sampling of multiple anatomical locations is readily accessible in the SIV-infected macaque models of

146 t that is derived from a simple, robust, and readily accessible (in multigram quantities) chiral amin

147 Thus, EPCs could become readily accessible informers of vascular status and enab

148 These readily accessible intermediates are converted to transi

149 For biological fluids, the most readily accessible is blood, and metabolomic analyses ca

150 rationally simple approach that makes use of readily accessible isoxazolinones.

151 pared in a one step, gram-scale fashion from readily accessible KATs.

152 Transformations are promoted by a readily accessible l-threonine-derived aminophenol-based

153 ing only picomole quantities of material and readily accessible laboratory equipment.

154 e starting alkene configurations, and uses a readily accessible ligand.

155 a non-invasive means to obtain abundant and readily accessible "liquid biopsies".

156 TCs), which are prevalent in SCLC, present a readily accessible 'liquid biopsy'.

157 cally labile protecting groups or for use in readily accessible materials that respond to mechanical

158 rotein conformational changes, and provide a readily accessible means of studying protein structure i

159 experimental guidelines for observation in a readily accessible measurement regime.

160 en]) through postsynthetic modification of a readily accessible meso-(2-aminophenyl) tris-substituted

161 ities should emphasize the identification of readily accessible metabolic biomarkers of responsivenes

162 These findings offer a powerful, readily accessible method for the rational design of can

163 that CEST provides an accurate, precise, and readily accessible method to noninvasively measure liver

164 sms encode carbohydrate esterases that strip readily accessible methyl and acetyl groups from polymer

165 Since the system is so easily assembled from readily accessible modules, various functional groups ca

166 ed, size-tunable nucleic acid particles from readily accessible molecular building blocks.

167 mmercially available and inexpensive CuCl, a readily accessible monodentate imidazolinium salt, and c

168 ally being sought which can be produced from readily accessible monomers, which can be tuned for drug

169 docyclopropenes by combining an isolable and readily accessible N,N'-diamidocarbene (DAC) with a rang

170 ives containing two stereogenic centers from readily accessible N,N-disubstituted glycine aryl esters

171 ant of the Smiles rearrangement that employs readily accessible N-aryl anthranilamides as precursors

172 Herein, we report a readily accessible N-mercaptoethoxyglycinamide (MEGA) so

173 A readily accessible new class of near infrared (NIR) mole

174 Reactions may be catalyzed by 5.0 mol % of a readily accessible NHC-Cu complex at ambient temperature

175 We demonstrate hydrazonyl chlorides serve as readily accessible nitrileimine precursors, whose reacti

176 report a paired electrochemical coupling of readily accessible nitro-compounds with benzyl alcohols

177 xperimental quantity the rest potential is a readily accessible, nonperturbing metric of the equilibr

178 Here a readily accessible, novel method for quantitatively mapp

179 able information from biomedical research is readily accessible on the Internet, providing a powerful

180 and shape supramolecular structures are now readily accessible, only a few are known to accelerate c

181 The formation of boron enolates from readily accessible ortho-alkynylbenzeneboronic acids pro

182 ular information (delta and J), which is not readily accessible otherwise.

183 intermediates undergo in situ trapping with readily accessible oxadiazinones.

184 Conversion of readily accessible oxazole-5-trifluoroacetamides into th

185 22,25-octaethoxy-Pc), as well as its stable, readily accessible oxidized (2(+) and 2(2+)) and reduced

186 the far-reaching privacy concerns raised by readily accessible pathogen genomic data.

187 ndings represent a potentially effective and readily accessible pharmacologic approach to fertility p

188 Suzuki-Miyaura coupling reactions involving readily accessible phenolic derivatives such as aryl sul

189 Such reactions will be readily accessible photochemically and thermally, e.g.,

190 (DABCO) derivatives are synthesized from the readily accessible piperazines in 50-64% yield by cycliz

191 oach for the light-mediated epimerization of readily accessible piperidines to provide the more stabl

192 atic molecular cage COP-5 in one step from a readily accessible porphyrin-based precursor.

193 pyran is easily prepared in three steps from readily accessible precursors and is amenable to structu

194 esence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with amm

195 PCDCs can be easily prepared from readily accessible precursors by a variety of different

196 mellarins G (6) and D (7) were achieved from readily accessible precursors in the highest overall yie

197 an be achieved by ring closing metathesis of readily accessible precursors.

198 ic, diverse, spiroannulated pyrazolones from readily accessible precursors.

199 er natural product griffipavixanthone from a readily accessible prenylated xanthone monomer.

200 e most promising scaffold identified was the readily accessible proline derivative (e.g., 79).

201 The reaction between readily accessible propargyl acetates and sulfonyl azide

202 F formation are in linear correlation to the readily accessible properties of the linker substituent,

203 The reaction between readily accessible pyrazole and propargyl acetates in th

204 Thus, we establish ced as a readily accessible, quantitative descriptor of solvophob

205 oxide (TATP) can be easily manufactured from readily accessible reagents and is extremely difficult t

206 The respiratory system, although readily accessible, remains a challenging target, as eff

207 est that even highly homologous LHEs offer a readily accessible resource of related scaffolds that di

208 available Z-butene together with robust and readily accessible Ru-based dithiolate catalysts develop

209 gh computational and experimental studies, a readily accessible ruthenium catechothiolate complex was

210 ort a facile in situ synthesis that utilizes readily accessible SiCl4 cross-linking chemistry to crea

211 erate the parent 3,4-oxacyclic allene from a readily accessible silyl triflate precursor, and then tr

212 developing a polymeric ectopic scaffold in a readily accessible site under the skin.

213 -1H-1,2,3-triazol-4-yl)methyl)arylamide is a readily accessible small molecule scaffold for compounds

214 these findings support an important role for readily accessible small steps in protein evolution that

215 ydroboration of allenes 8 and 14a-d with the readily accessible Soderquist borane 7, which is generat

216 nversion devices due to their utilization of readily accessible solar energy; however, the output of

217 resources, providing a manually-curated and readily accessible source of age-related changes.

218 ost species, which by their abundance form a readily accessible source of blood.

219 iring iron as a cofactor demands that such a readily accessible source of iron exist, but overaccumul

220 oxol in 9 steps and 20% overall yield from a readily accessible starting material.

221 asymmetric [4+3] annulation reaction of two readily accessible starting materials has been developed

222 oxindole and (E)-3-allylidenebenzofuran from readily accessible starting materials using palladium bi

223 Easy operation, readily accessible starting materials, and short synthes

224 [4 + 2]-annulation lies in the employment of readily accessible starting materials, Morita-Baylis-Hil

225 approach to this class of heterocycles from readily accessible starting materials.

226 ters with improved properties, produced from readily accessible starting materials.

227 f 1,2,4-triazines under mild conditions from readily accessible starting materials.

228 ct route to alpha-oxidized thioimidates from readily accessible starting materials.

229 e to good yields from different low-cost and readily accessible starting materials.

230 r follicle represents a miniature organ with readily accessible stem cells, multiple cell lineages, a

231 a assets into digital biobanks-ecosystems of readily accessible, structured, and annotated datasets t

232 and interstitium making the immobilized Fg a readily accessible substrate for binding Abeta and cellu

233 d thiopyrano[3,4-c]pyridine derivatives from readily accessible substrates.

234 dihydroquinoline derivatives from simple and readily accessible substrates.

235 lasses for which reference standards are not readily accessible such as TPs of household chemicals.

236 Here we show that a readily-accessible sugar-polyolefin conjugate quantitati

237 ted at the base of a narrow cleft and is not readily accessible, suggesting a highly regulated cleava

238 LSF of drugs and drug candidates, useful and readily accessible synoptic tables of such transformatio

239 We hypothesized that the most readily accessible target in the versican-TLR2/6 pathway

240 ensite is also formed in situ, starting at a readily accessible temperature of 200 degrees Celsius.

241 y acquired at three magnetic fields that are readily accessible, the IMPACT analysis gives a satisfac

242 sIgG1/sIgE balance might represent a readily accessible therapeutic target for asthma/rhiniti

243 d in good to excellent yields, starting from readily accessible thiosemicarbazides, bis-diarylthioure

244 etones to generate ethers are catalyzed by a readily accessible thiourea organocatalyst that operates

245 The oxalyl unit, readily accessible through commercially available starti

246 d pore surfaces have been demonstrated to be readily accessible, thus providing more opportunities fo

247 However, the ability to reprogram readily accessible tissue from patients into pluripotent

248 Furthermore, muscle may provide a readily accessible tissue in which to monitor therapeuti

249 In contrast, the C terminus was readily accessible to antibodies at the cell surface and

250 In general, host apolipoproteins were more readily accessible to antibody labeling than HCV glycopr

251 , and partially disordered structure, is not readily accessible to any of the typical structure deter

252 e copper site of SOD5 is not recessed and is readily accessible to bulk solvent.

253 olecules at the surface of blood vessels are readily accessible to circulating compounds.

254 eaction mechanisms and pathways, but are not readily accessible to conventional optical spectroscopic

255 However, these approaches are not readily accessible to every researcher.

256 y wall of Drosophila melanogaster larvae are readily accessible to experimental manipulation.

257 his intriguing regime, however, has not been readily accessible to experimentalists because of the la

258 y to other exothermic reactions that are not readily accessible to investigation by more conventional

259 a in Mouse Genome Informatics (MGI) and made readily accessible to many types of database searches.

260 ose multiple broadly cross-reactive epitopes readily accessible to NAbs.

261 on is ligand-dependent, the P2204L mutant is readily accessible to PKA, promoting ligand-independent

262 undant, not considered high quality, and not readily accessible to researchers in a systematic fashio

263 even with highly abundant cytosolic proteins readily accessible to the bud neck (including molecular

264 Institute (EBI) is committed to making data readily accessible to the community in ways that meet ex

265 d to the ER membrane with their protein bulk readily accessible to the cytosolic proteasome.

266 bled the development of a web server that is readily accessible to the practising biologist while pro

267 nt tool to make biobank's valuable data more readily accessible to the research community and facilit

268 Published time estimates are now readily accessible to the scientific community, K-12 and

269 atiotemporal expression patterns in a format readily accessible to the scientific community.

270 response to exogenous stimuli and makes them readily accessible to topical drugs.

271 search findings need to be compiled and made readily accessible to users for policy making, programmi

272 These probes therefore represent a readily accessible toolkit to monitor cellular signaling

273 eneous cell populations creates the need for readily accessible tools for the analysis of single-cell

274 ic cages via one-step alkyne metathesis from readily accessible triyne precursors is presented.

275 Readily accessible unsaturated organoboron compounds ser

276 virus 6 to correct the DeltaF508 mutation in readily accessible upper-airway basal stem cells (UABCs)

277 hard to synthesize or require multisteps are readily accessible using a common set of reaction condit

278 -H activation, these transformations are not readily accessible using modern synthetic organic techni

279 Previously, these were not readily accessible using palladium catalysis.

280 ron-based catalyst, generated in situ from a readily accessible valine-derived aminophenol and a Z- o

281 As the eye is a readily accessible VEGF laboratory, features expressed t

282 intimate contact with the solution phase and readily accessible via "liquid-like" diffusion.

283 a highly fluorescent small molecule which is readily accessible via a two-step synthesis.

284 selected as starting compound because it is readily accessible via acid-mediated Grob fragmentation-

285 detection and comparative analysis tools are readily accessible via SecReT6, which may aid identifica

286 pothesized that the imidazo[1,2-a]pyrazines, readily accessible via the Groebke-Blackburn-Bienayme mu

287 ntaining dual sp(3)-hybridized C centers are readily accessible via this platform, and the herein dem

288 applied to features manually extracted from readily accessible videos (e.g., from smartphones) has t

289 f the Fermi velocity in Dirac materials in a readily accessible way for experiments.

290 creen analysis more reliable as well as more readily accessible, we have developed a new algorithm, c

291 e potential of iPSCs is the establishment of readily accessible well-characterized panels of lines fo

292 strands, and chain-end biotin groups become readily accessible, while at lower temperatures these ac

293 des, dinitriles, etc., many of which are not readily accessible with alternative methods.

294 Given that functionalized cyclohexanones are readily accessible with complete regiocontrol using the

295 ulation information about face viewpoint was readily accessible with fMRI MVPA from all face patches,

296 structures to engage biological pathways not readily accessible with linear oligonucleotides.

297 n information for defined lipids that is not readily accessible with nonmass spectrometric methods.

298 um for photocatalysis of water splitting, is readily accessible with these systems.

299 te that human ability to keep information in readily accessible working memory is limited to four ite

300 ynthesis of highly substituted oxazoles from readily accessible ynamides in the presence of ytterbium