ライフサイエンスコーパス: receptor internalization

1 ement and consequent activation, measured as receptor internalization.

2 cling to the cell surface, with no effect on receptor internalization.

3 athogenesis driven by immunoglobulin-induced receptor internalization.

4 d downstream events: Akt phosphorylation and receptor internalization.

5 igands CCL17 and CCL22, in part by impairing receptor internalization.

6 uired for G protein-independent constitutive receptor internalization.

7 d cognitive deficits and decreased glutamate receptor internalization.

8 ng receptor-G-protein coupling and promoting receptor internalization.

9 in signaling, beta-arrestin recruitment, and receptor internalization.

10 ssay gave no evidence for desensitization or receptor internalization.

11 tein- or beta-arrestin-mediated signaling or receptor internalization.

12 spinal cord by visualizing neurokinin type 1 receptor internalization.

13 cruitment of beta-arrestin-2, and subsequent receptor internalization.

14 signaling in the pIIb cell by driving Notch receptor internalization.

15 osphorylation on S351, a residue crucial for receptor internalization.

16 er, preventing beta-arrestin recruitment and receptor internalization.

17 r recycling but has no effect on transferrin receptor internalization.

18 ole in SDF-1alpha signaling via CXCR4 and/or receptor internalization.

19 tein or second-messenger pathway followed by receptor internalization.

20 marked functional selectivity of cannabinoid receptor internalization.

21 ulation, [(35)S]GTPgammaS binding, and CB(1) receptor internalization.

22 vation is inhibited correlating with reduced receptor internalization.

23 PCR to facilitate effective NHERF1-dependent receptor internalization.

24 agonist-induced receptor phosphorylation or receptor internalization.

25 asurements of beta-arrestin2 association and receptor internalization.

26 regions influence the overall efficiency of receptor internalization.

27 nd negative allosteric modulation of mGlu(5) receptor internalization.

28 n uncover unique ligand efficacies linked to receptor internalization.

29 ed by receptor activation, without affecting receptor internalization.

30 nner and a PKC inhibitor blocked dopamine D2 receptor internalization.

31 341/343 and then on Thr-353/354, followed by receptor internalization.

32 its endocytic adaptor activity to facilitate receptor internalization.

33 density membrane domains and to TNF-induced receptor internalization.

34 membrane, is also thought to be involved in receptor internalization.

35 mulated cell migration and in regulating EGF receptor internalization.

36 valent CCK(2) antagonist 2 did not stimulate receptor internalization.

37 help to sustain TcR/CD3 signaling after the receptor internalization.

38 indicating that the antagonist could induce receptor internalization.

39 ow that full VEGFR3 signalling is coupled to receptor internalization.

40 tures, Abeta treatment failed to induce NMDA receptor internalization.

41 of chemokines did not significantly enhance receptor internalization.

42 the dynamin inhibitory peptide, which blocks receptor internalization.

43 ires sodium influx, proteasomal activity and receptor internalization.

44 ncreased affinity for CXCR4 and to efficient receptor internalization.

45 with increases in cluster size and rates of receptor internalization.

46 utophosphorylation as well as ligand-induced receptor internalization.

47 arrestin 3 without affecting agonist-induced receptor internalization.

48 agonist-activated 7TMRs, thereby regulating receptor internalization.

49 f beta-arrestin2 to the plasma membrane, and receptor internalization.

50 trate underlying receptor desensitization is receptor internalization.

51 avy chain/beta-adaptin, thereby accelerating receptor internalization.

52 ck G protein signaling but enable or promote receptor internalization.

53 uitment of beta-arrestin-2 to the microOR or receptor internalization.

54 wing ligand binding but cap with CCR7 during receptor internalization.

55 itment of beta-arrestin-2 to the microOR and receptor internalization.

56 aling owing to its participation in TGF-beta receptor internalization.

57 synaptic sites, where it regulates glutamate receptor internalization.

58 e of ubiquitination and a complete rescue of receptor internalization.

59 marginally recruiting beta-arrestin, with no receptor internalization.

60 a molecular chaperone for clathrin-mediated receptor internalization.

61 is critical for receptor degradation and not receptor internalization.

62 lly triggers EGFR Thr654 phosphorylation and receptor internalization.

63 ls, yet, ubiquitinylation is dispensable for receptor internalization.

64 and the ability to enhance beta2-adrenergic receptor internalization.

65 he role of receptor oligomerization in CXCL8 receptor internalization.

66 GluR1 serine 845 triggers NMDA-induced AMPA receptor internalization.

67 the EGFR, thus leading to the inhibition of receptor internalization.

68 re necessary for caveolae-dependent TGF-beta receptor internalization.

69 rmation, which triggers MAPK recruitment and receptor internalization.

70 of a muscarinic depolarizing current and M1 receptor internalization.

71 companied chemical induction of LTD and AMPA receptor internalization.

72 be, at least in part, the consequence of M1 receptor internalization.

73 n Arrb2 than females, suggesting greater CRF receptor internalization.

74 vity-dependent versus constitutive glutamate receptor internalization.

75 pine cytoskeleton and facilitating glutamate receptor internalization.

76 has been shown to mediate synaptic glutamate receptor internalization.

77 ET-negative feedback loop, which accompanies receptor internalization.

78 , which then facilitates desensitization and receptor internalization.

79 lar applications of p4, a blocker of GABA(A) receptor internalization.

80 likely resulting from Nef- and Env-mediated receptor internalization.

81 : cAMP generation, MAP kinase activation and receptor internalization.

82 line behavior (i.e., "overshoot") was due to receptor internalization.

83 in and other proteins--eventually leading to receptor internalization.

84 that retains Akt at the membrane, and not by receptor internalization.

85 as analyzed the role of cell morphology and receptor internalization.

86 e activation in parallel with inhibited EGFR receptor internalization.

87 Thus, for rapid and maximal S1P1 receptor internalization a high potency in both G alphai

88 MI alone was found to be sufficient to drive receptor internalization acutely and a robust down-regul

89 ected cell-surface receptors, we discuss how receptor internalization affects signaling specificity a

90 hine and DAMGO display different profiles of receptor internalization and a similar ability to trigge

91 X-C chemokine ligand 12 (CXCL12), results in receptor internalization and activation of several signa

92 nd negative allosteric modulation of mGlu(5) receptor internalization and adds significant new knowle

93 ist D-[Pen(2),Pen(5)]enkephalin could induce receptor internalization and adenylyl cyclase (AC) desen

94 by preventing G-protein coupling, triggering receptor internalization and affecting various downstrea

95 Aggregation caused dysregulated AMPA receptor internalization and also inhibited CME in prima

96 of Akt but instead significantly compromised receptor internalization and arrestin 3 recruitment.

97 S)-remeglurant were biased toward (affinity) receptor internalization and away (cooperativity) from t

98 o residue 381 did not affect agonist-induced receptor internalization and beta-arrestin2 translocatio

99 S295D) of PSD-95 inhibited NMDA-induced AMPA receptor internalization and blocked the induction of LT

100 ), which exhibit opposite profiles on apelin receptor internalization and BP.

101 ncy was assessed by immunofluorescence-based receptor internalization and Ca(2+) mobilization assays.

102 he importance of these domains in regulating receptor internalization and cell activation, we lentivi

103 osphorylation sites on the beta(2)AR blocked receptor internalization and coupling to G(i) proteins,

104 ivity via a mechanism likely reflecting AMPA receptor internalization and creation of silent or immat

105 roligin-3 and AMPA receptors, increases AMPA-receptor internalization and decreases postsynaptic AMPA

106 n 17 (K17F) is crucial for triggering apelin receptor internalization and decreasing blood pressure (

107 with the group C adenovirus protein known as receptor internalization and degradation alpha (RIDalpha

108 tion of matrix adhesion promotes uniform FGF receptor internalization and degradation while enhanced

109 ephrin-A1 does not efficiently induce EphA2 receptor internalization and degradation, and does not a

110 eral receptor tyrosine kinases by triggering receptor internalization and degradation.

111 an antagonist of S1P1, VPC 44116, prevented receptor internalization and degradation.

112 protein coupling, adenylyl cyclase activity, receptor internalization and desensitization, and post-e

113 lation sites, with possible consequences for receptor internalization and desensitization.

114 this study, we investigated parameters of DC receptor internalization and determined how they impact

115 hanisms such as beta-arrestin recruitment or receptor internalization and endocytic trafficking.

116 gnaling was limited to modest ligand-induced receptor internalization and ERK1/2 phosphorylation in r

117 sly unrecognized link between ARF6-regulated receptor internalization and events that drive dramatic

118 ctin polymerization, which resulted in rapid receptor internalization and failure to support downstre

119 eceptor and is required for a rapid phase of receptor internalization and for functional signaling vi

120 ptor sites within cluster 1 had no effect on receptor internalization and had a less extensive effect

121 l change of CXCR4 on Rac1 inhibition blocked receptor internalization and impaired CXCL12-induced Gal

122 mutation of Leu-773 but not Tyr-770 impaired receptor internalization and increased receptor stabilit

123 proportionality between stimulation and both receptor internalization and inhibitor response, reflect

124 owth factor induced the kinase insert domain receptor internalization and interaction through C-termi

125 endogenous ARF6 activation and constitutive receptor internalization and is reversed by ARF6 inhibit

126 Loss of p85beta impaired ligand induced KIT receptor internalization and its overexpression enhanced

127 In particular, prolactin receptor internalization and localization was altered in

128 metabotropic glutamate receptor-induced AMPA receptor internalization and LTD both in wild-type and i

129 K activity was required for initiating micro receptor internalization and maintaining possible micro-

130 Here, we identify the mediators of CB1 receptor internalization and ORG27569-induced G protein-

131 Moreover, excess cholesterol could evoke receptor internalization and protein kinase C-independen

132 changes in G protein localization depend on receptor internalization and receptor-Galpha coupling.

133 The effect of NHERF1 on receptor internalization and recycling was not associate

134 a(2)ARs underwent slow GRK2 phosphorylation, receptor internalization and recycling, and failed to co

135 iquitin, with AMPAR ubiquitination enhancing receptor internalization and reducing AMPAR cell surface

136 ction with arrestins, whose binding promotes receptor internalization and signaling through G protein

137 ate a novel role for Parkin in synaptic AMPA receptor internalization and suggest a Parkin-dependent

138 ortant role of caveolin-1 (CAV1) in TGF-beta receptor internalization and TGF-beta signaling, the par

139 nding does not stimulate natriuretic peptide receptor internalization and that cellular environment d

140 We show that beta-arrestins are required for receptor internalization and that only beta-arrestin2 ca

141 ased with respect to the rate or duration of receptor internalization and that receptor internalizati

142 ctively induces weak chemotaxis and leads to receptor internalization and the beta-arrestin 2 recruit

143 PSD-95-T19A, but not WT-PSD-95, impairs AMPA receptor internalization and the induction of LTD.

144 urther show that KCTD12 reduces constitutive receptor internalization and thereby increases the magni

145 ses KIR3DL1 inhibitory function, and reduces receptor internalization and turnover.

146 BDNF transiently activates TrkB, leading to receptor internalization and ubiquitination/degradation,

147 However, sst2A receptor internalization and uncoupling can occur indepe

148 n at different sites has distinct effects on receptor internalization and uncoupling.

149 e requires transmitter-receptor interaction, receptor internalization, and a protein kinase C-depende

150 By contrast, the recruitment of arrestin 3, receptor internalization, and activation of Akt were reg

151 anslocation to the membrane, agonist-induced receptor internalization, and agonist-induced desensitiz

152 phosphorylation, beta-arrestin recruitment, receptor internalization, and beta-arrestin-dependent ER

153 h CDR formation, including macropinocytosis, receptor internalization, and cell migration.

154 en required to initiate signal transduction, receptor internalization, and cellular activation.

155 ed CXCR4- and G protein-dependent signaling, receptor internalization, and chemotaxis in CXCR4-expres

156 d receptors at the membrane, did not enhance receptor internalization, and decreased the amount of ph

157 ble complex formation, betaarr1 recruitment, receptor internalization, and desensitization of G-prote

158 ated synaptic protein synthesis, excess AMPA receptor internalization, and increased spine density.

159 ts, including ligand binding, ligand-induced receptor internalization, and ligand-stimulated intracel

160 were associated with enhanced CXCR4 binding, receptor internalization, and restored chemotaxis.

161 Treatment with doxazosin triggered EphA2 receptor internalization, and suppressed haptotactic and

162 ions to recruit endocytic machinery for AMPA receptor internalization, and this action, together with

163 esidues that underlie acute desensitization, receptor internalization, and tolerance and examined fou

164 on of beta-arrestin2 to the plasma membrane, receptor internalization, and uncoupling from G proteins

165 ection, including attachment to the cellular receptor, internalization, and virus genome transfer int

166 tment of beta-arrestin to the beta2AR; (iii) receptor internalization; and (iv) activation of extrace

167 LTD and AMPA receptor internalization are blocked by peptide inhibito

168 re we show that drug-specific differences in receptor internalization are determined by a conserved,

169 on on membrane translocation of arrestin and receptor internalization are due, at least in part, to d

170 kinase phosphorylation of beta(2)AR and the receptor internalization are much slower than that induc

171 e now examine the effect of these ligands on receptor internalization as a mechanism of receptor regu

172 heless, activation does increase the rate of receptor internalization as does disruption of rafts wit

173 The antibodies are responsible for receptor internalization, as their depletion from CSF ab

174 A live-cell receptor internalization assay was used to test the abil

175 1/2 (ERK1/2) phosphorylation, and real-time receptor internalization assays on rat mGlu(5) expressed

176 cumulation, beta-arrestin-2 recruitment, and receptor internalization assays.

177 ated endocytosis (CME) is the major route of receptor internalization at the plasma membrane.

178 n cells were stimulated long enough to allow receptor internalization before agonist removal.

179 ggering via antibody binding rapidly induces receptor internalization but does not affect TLR-induced

180 and CC chemokines to undergo ligand-induced receptor internalization, but is not coupled to trimeric

181 immunoreceptor aggregates and a trigger for receptor internalization, but is not required for tyrosi

182 nd that mGluR activation causes LTD and AMPA receptor internalization, but no spine shrinkage in eith

183 intracellular sorting steps that occur after receptor internalization by endocytosis provide a critic

184 Receptor internalization can occur through different rou

185 estin translocation, ERK phosphorylation and receptor internalization confirmed that GPR35 functions

186 at both beta-arrestin recruitment and apelin receptor internalization contribute to the K17F-stimulat

187 igh-throughput flow cytometry measurement of receptor internalization described by Wu et al. in the c

188 proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II

189 ntion of beta1AR-EGFR interaction throughout receptor internalization, direct EGF ligand stimulation

190 Further studies documented that receptor internalization, down-regulation, direct recycl

191 f surface alpha(1a)AR levels indicate modest receptor internalization during the 10 min following sti

192 50]: 0.21 +/- 0.18 vs. 1.38 +/- 0.54 nM) and receptor internalization (EC50: 41.9 +/- 29.8 vs. 455 +/

193 the ability of these new agonists to induce receptor internalization, ERK activation, and chemotaxis

194 inase-interacting protein 2 (GIT2) regulates receptor internalization, focal adhesion dynamics, cell

195 cipates in many cellular functions including receptor internalization, focal adhesion remodeling, and

196 Agonist-induced receptor internalization followed a clathrin- and dynami

197 This study highlights the importance of receptor internalization for full functionality of GLP-1

198 th the receptor during receptor activity and receptor internalization from the cell surface.

199 By comparing stimulus bias factors among receptor internalization, G protein activation, extracel

200 well described components of MOP signaling: receptor internalization, G protein coupling, and activa

201 l NAMs inhibited l-glutamate-induced mGlu(5) receptor internalization, generally with a similar poten

202 is finding is potentially important, because receptor internalization has been associated with develo

203 Receptor internalization has been implicated in VEGFR2 s

204 e actin cytoskeleton to facilitate glutamate receptor internalization has not been demonstrated.

205 ead compound 2 potently inhibits S1P-induced receptor internalization in a cell-based assay (EC50 = 0

206 n p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization in a clathrin/dynamin-dependent

207 th a number of compounds that might regulate receptor internalization in a nontraditional manner.

208 n, but its last eight amino acids facilitate receptor internalization in concert with beta-arrestin2.

209 d EGFRvIII and demonstrate the importance of receptor internalization in distinguishing their specifi

210 r prolonged periods after ligand washout and receptor internalization in endosomes.

211 e 2 (SphK2) in vitro, and did not cause S1P1 receptor internalization in HCC cells or T lymphocyte ho

212 ia mitochondria is required for LTD and AMPA receptor internalization in hippocampal neurons.

213 -hydroxy-5-methyl-4-isoxazolepropionic acid) receptor internalization in hippocampal neurons.

214 o the membrane and decreased agonist-induced receptor internalization in human embryonic kidney 293 c

215 NHERF1 also inhibited PTH-induced receptor internalization in MC4 osteoblast cells.

216 tion, we did not detect any Abeta-evoked NK1 receptor internalization in neurons from laminas I, III,

217 forms, and the same sequence controls opioid receptor internalization in neurons.

218 cellular calcium, ERK1/2 phosphorylation, or receptor internalization in receptor-bearing COS or CHO-

219 a-arrestin-1, suggesting a possible role for receptor internalization in this process.

220 Compound 101 blocked receptor internalization in tissue from both naive and m

221 n occurs through Src-family kinase-dependent receptor internalization in vitro and in vivo, presumabl

222 The D2/D3 agonist quinpirole, which induces receptor internalization in vitro, was administered at g

223 ng G alphai signaling determines the rate of receptor internalization in vitro.

224 gnition in vitro also abolish NPFxD-mediated receptor internalization in vivo.

225 Receptor internalization, in contrast, seems to be essen

226 the dynamics of agonist-induced cell surface receptor internalization, in which lack of phosphorylati

227 Receptor internalization increases the flexibility and s

228 urface expression of CXCR7 without affecting receptor internalization, indicating that receptor recyc

229 and GFP2-K-Ras was robustly diminished after receptor internalization induced by dopamine, with subse

230 imatinib blocked tolerance without altering receptor internalization induced by either morphine or f

231 ly attenuates the DNIC and neurokinin type 1 receptor internalization induced either by heat or mecha

232 Blocking receptor internalization inhibited Akt phosphorylation,

233 Blocking receptor internalization, inhibiting PKA II/interfering

234 PTHR signaling requires receptor internalization into endosomes, which is then t

235 d beta-arrestin-mediated desensitization and receptor internalization into endosomes.

236 alterations are accompanied by growth factor receptor internalization into signaling endosomes and re

237 Receptor internalization is a mechanism by which recepto

238 Receptor internalization is a well-documented method cel

239 These results demonstrate that engineered receptor internalization is an effective strategy for re

240 Receptor internalization is associated with a late cAMP/

241 zation was not as efficient, suggesting that receptor internalization is required but not sufficient

242 First, we show that receptor internalization is required for agonist-induced

243 A variety of events such as receptor internalization, kinase activation, and actin r

244 ir unbiased mode of inhibition that prevents receptor internalization, leading to drug tolerance.

245 , we show that adhesion inhibits mitotic FGF receptor internalization, leading to receptor enrichment

246 or (EGFR) has been implicated in EGF-induced receptor internalization, lysosomal degradation, and dow

247 Therefore, receptor internalization may be a generic requirement fo

248 uration of receptor internalization and that receptor internalization may be independent of activatio

249 Ligand binding and receptor internalization modulated IL-15R occupancy.

250 that deletion of this ligand effects neither receptor internalization nor receptor recycling.

251 Our data indicate a rapid constitutive receptor internalization of the cell surface hCaR, accum

252 of fibrinogen to its alphaIIbbeta3 integrin receptor, internalization of the alphaIIbbeta3 complex,

253 Current methods for screening cell receptor internalization often require complex image ana

254 ns, induced chemotaxis, but failed to induce receptor internalization or beta-arrestin 2 recruitment.

255 mGluR5 availability in the EZ might reflect receptor internalization or conformational changes in re

256 lly restricted arrestin mutant did not cause receptor internalization or desensitization but did prom

257 nce of a QD tag does not interfere with 5-HT receptor internalization or endosomal recycling.

258 pO specifically blocks Rac-dependent Fcgamma receptor internalization pathway but not complement rece

259 agonist, nociceptin, caused robust NOPR-YFP receptor internalization, peaking at 30 min.

260 n-coupled receptor action by enabling faster receptor internalization, possibly through a direct asso

261 inhibition of opioid release and not of the receptor internalization process, because 8-OH-DPAT did

262 trinsically regulated by adaptor protein and receptor internalization processes.

263 the cell surface, as well as tracking of the receptors' internalization processes on the addition of

264 ormation, whereas Bcr prevents Rac1-mediated receptor internalization, promoting spine growth over re

265 diverse functions, including ligand binding, receptor internalization, proper folding, and export, as

266 cognate cell-surface receptor often promotes receptor internalization, protecting cells from prolonge

267 o recruit beta-arrestins, and did not induce receptor internalization, providing the first clear exam

268 differential STAT phosphorylation profiles, receptor internalization rates, and downstream gene expr

269 We also found that constitutive receptor internalization/recycling and ligand uptake are

270 the general concepts of receptor signaling, receptor internalization, regulation of distinct signali

271 mating-induced gene expression and activate receptor internalization, respectively.

272 a-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogen

273 was also observed, as CXCL11 induced faster receptor internalization, slower recycling, and longer i

274 -phosphate (S1P)(1) receptor, induces S1P(1) receptor internalization sufficiently in the presence or

275 , into the cell membrane after CCL2-mediated receptor internalization, suggesting a mechanism of acti

276 tibody was shown to induce a higher level of receptor internalization than the combination of two par

277 790M EGFR competes with acetylation-mediated receptor internalization that correlates with enhanced r

278 on of the MOR at the plasma membrane (before receptor internalization) that facilitates transient act

279 s a gateway for cellular control of synaptic receptor internalization through second messenger signal

280 isrupted later steps of MC4R and transferrin receptor internalization to endosomes as well as traffic

281 sphorylation, beta-arrestin recruitment, and receptor internalization to varying extents.

282 sphorylation of gamma2 Y365 and Y367 reduces receptor internalization, to understand their importance

283 ependence arises from the effects of CXCR1/2 receptor internalization, TyrRS(Mini) does not induce in

284 the critical role of beta-arrestin 2 in CB1 receptor internalization upon treatment with CP55940 (ag

285 the structural determinant(s) that modulate receptor internalization, various chimeric and point mut

286 Receptor internalization was impaired by small interferi

287 re switched from transient to sustained when receptor internalization was inhibited with drugs or mut

288 ion of receptor immunoreactivity, whereas M1 receptor internalization was not affected by loss of GRK

289 f G(s) signaling, arrestin mobilization, and receptor internalization was observed upon alanine subst

290 Receptor internalization was transiently detected in a s

291 beta1 endocytosis was impaired, transferrin receptor internalization was unaffected.

292 d methodologies, including a novel assay for receptor internalization, we show that the majority of k

293 ts with regard to cAMP production and apelin receptor internalization, whereas 21 is a biased agonist

294 r aminoalkylindoles) failed to promote CB(2) receptor internalization, whereas 5-(1,1-dimethylheptyl)

295 ypertonic sucrose or dynasore, which prevent receptor internalization, whereas dephosphorylation of S

296 ary and sufficient for efficient Epo-induced receptor internalization, whereas ubiquitination at Lys(

297 ructural determinants regulating the rate of receptor internalization, which in turn controlled the a

298 Arrestin-dependent receptor internalization, which requires arrestin bindin

299 e desensitization of G-protein signaling and receptor internalization while simultaneously eliciting

300 ist-induced beta-arrestin2 translocation and receptor internalization yet significantly attenuated re