ライフサイエンスコーパス: recognition site

1 location (25-27 bp downstream of one of the recognition sites).

2 ictated by the rate of dissociation from the recognition site.

3 DNA where both Myb-like domains bind to the recognition site.

4 le for a conserved tyrosine and distinct S1' recognition site.

5 d to DNA containing a consensus (5')GGAA(3') recognition site.

6 cific overall structure and potential ligand recognition site.

7 bond as a binding element at the fibrinogen recognition site.

8 neously flips its binding orientation at the recognition site.

9 head region that are clustered about the RGD recognition site.

10 s a transient, stretched conformation of its recognition site.

11 +) binding and probably represents a protein recognition site.

12 ys and by the identification of a beta-TrCP1 recognition site.

13 for a cytosine base upstream of the core RNA recognition site.

14 ved from this compound bear an amidopyridine recognition site.

15 acts to the B-B' loop of CYP3A4, a substrate recognition site.

16 nuclease homodimer bound to its specific DNA recognition site.

17 he alpha(M)-I domain represents a major LRP1 recognition site.

18 the alpha(M)-I domain represent a major LRP1 recognition site.

19 t was abrogated by mutation of the consensus recognition site.

20 s phosphorylated at Ser-383, a consensus WNK recognition site.

21 nstream on the complementary strand of the J-recognition site.

22 ealed a greater flexibility in its substrate recognition site.

23 s to show that FANCJ possesses a G4-specific recognition site.

24 y cleavage-resistant as they lack a complete recognition site.

25 of the five base pairs of the (5'-GANTC-3') recognition site.

26 previously untargeted areas of the substrate recognition site.

27 observable when DNA ends are proximal to the recognition site.

28 ity interactions of antibodies and different recognition sites.

29 adruplex structure flanked by nicking enzyme recognition sites.

30 h and without target RNAs representing miRNA recognition sites.

31 F mucins revealed mucin cleavage at antibody recognition sites.

32 recognition of DNA sequences resembling RAG recognition sites.

33 small insertion/deletions produced at CRISPR recognition sites.

34 histories, and identification of allergenic recognition sites.

35 multaneously specify both amino acids and TF recognition sites.

36 o previously identified cholesterol and drug recognition sites.

37 onal changes that lead to exposure of active recognition sites.

38 d may have altered aminoacyl-tRNA synthetase recognition sites.

39 rmitted the identification of putative dsRNA recognition sites.

40 precursors at related but distinct S/A/G-X-E recognition sites.

41 ompeted with mAbs, suggesting broadly shared recognition sites.

42 ed to include fifteen new restriction enzyme recognition sites.

43 of eight specificity proteins with distinct recognition sites.

44 coli cells (E. coli UTI89) using artificial recognition sites.

45 iR-430 seeds, AU-rich sequences, and Pumilio recognition sites.

46 can selectively target specific cell-surface recognition sites.

47 on of differential RNA binding protein (RBP) recognition sites.

48 ave substrates containing nicks within their recognition sites.

49 hould allow rapid methylation of host genome recognition sites.

50 1441C/G/H, which are part of a consensus PKA recognition site ((1441)RASpS(1444)).

51 ngement of residues forming the acetyllysine recognition site, affecting plasticity of the protein in

52 is expressed inside cells, it cleaves at the recognition site, allowing the DNAzyme to adopt its acti

53 Structural optimization of the chaperone recognition site allows it to bypass quality control che

54 The presence of both a PUM recognition site and a recognition site for preferential

55 en designed to bind at the amyloid-beta self-recognition site and prevent amyloid-beta from misfoldin

56 conserved hydrophobic wedge next to the PI4P recognition site and ringed by a network of complementar

57 iations in the length and composition of the recognition site and the cluster template indicate that

58 re shows a scattered pattern, but the origin recognition site and the nuclease active site are invari

59 case domain located > 45 A from both the Chi-recognition site and the nuclease active site.

60 lecular axle comprised of a dibenzylammonium recognition site and two azobenzene end groups and a dib

61 iments for seven systems featuring different recognition sites and backbones.

62 eric signaling between promiscuous molecular recognition sites and can inform the rational design of

63 isfolded proteins through distinct substrate recognition sites and conjugates these proteins with the

64 Type IIB nucleases require two recognition sites and cut both strands on both sides of

65 ognition can mimic key aspects of biological recognition sites and drug targets, opening up possibili

66 R372A/R1689A fVIII lacks proteolytic recognition sites and is not released from VWF.

67 hile also allowing for the generation of new recognition sites and specialized cellular functions.

68 he DNA, either downstream or upstream of the recognition site, and an acceptor placed on the catalyti

69 mination of the ligand mechanical footprint, recognition site, and binding orientation.Mapping the se

70 HEs) are compact endonucleases with 20-22 bp recognition sites, and thus are ideal scaffolds for engi

71 the N-terminal domain, and all carbohydrate recognition sites are available for binding glycans.

72 ion channels with single-file multiple anion-recognition sites are rare.

73 In the R series, the -NH(2)(+)- recognition sites are separated by trismethylene bridges

74 Although their recognition sites are separated by up to 90 bp, Fis repr

75 idea here is that in the former series, the recognition sites are strategically positioned 3.5 A apa

76 Tailor-made selective artificial recognition sites are thus introduced into the tubular m

77 two unusual "half-crown/two carbonyl" cation recognition sites as revealed by the combination of sing

78 The 3' recognition site associates with a complementary target

79 ically mutating the putative miR-275/miR-306 recognition site at the bam 3'UTR.

80 ologous templates, for insertion of an EcoRI recognition site at the RIF1 locus and introduction of a

81 Additional recognition sites at loci distant from oriC modulate Dna

82 d NIX expression vectors lacking the miR-137 recognition sites at their 3' UTR.

83 that Tye7p often binds promoters without its recognition site because it is recruited by other collec

84 The tetramer bridges two recognition sites before eventually cutting the DNA in b

85 tions brought about by both pi-electron-rich recognition sites being part of a macrocyclic polyether.

86 l-defined mechanical states by incorporating recognition sites between the different components.

87 th a model where ATP hydrolysis activated by recognition site binding leads to release of the enzyme

88 3 associates with itself by the carbohydrate recognition site binding to another galectin-3 molecule,

89 An intrasubunit site is adjacent to the GABA-recognition site but faces the channel vestibule.

90 assembly is then guided by low-affinity DnaA recognition sites, but is also regulated by a switch-lik

91 cturally transforming a loop adjacent to the recognition site by duplicating the volume of the preQ(1

92 t opens a transient subpocket in the preQ(1)-recognition site by pushing back an aspartate residue.

93 e upstream cytosine relative to the core PUF recognition site can differ, which in the case of FBF-2

94 k, nitrone N bearing a 6-methylamidopyridine recognition site can participate in 1,3-dipolar cycloadd

95 The rates of the transitions between the recognition sites can be controlled by introducing steri

96 ency, strain specificity, restriction enzyme recognition site changes and flanking primers for all SN

97 or that uses mutant "cross-over insensitive" recognition sites combined with an "ATG-out" design.

98 inal half) and only one functional anticodon recognition site (contributed by the C-terminal half).

99 The complementarity between recognition sites creates a key conformational equilibri

100 We identified a LonA-recognition site critical for oxidation-controlled PerR

101 ls of both cellular copy numbers and genomic recognition site densities.

102 oriC, closely spaced high- and low-affinity recognition sites direct DnaA-DnaA interactions and coup

103 events require binding of at least a second recognition site either in cis or in trans.

104 e relative position of their carboxylic acid recognition site: either para (M(p)) or meta (M(m)) rela

105 The metal recognition site exhibits small motions in the apo state

106 res long-range protein communication between recognition sites facilitated by thermally-driven 1D dif

107 he stable integration of endonuclease I-SceI recognition sites flanked by bacterial LacO/TetO operato

108 entified a common structure that serves as a recognition site for AP-1 binding and governs Golgi expo

109 activity, and those bases form an asymmetric recognition site for FlhD(4)C(2).

110 This signal patch forms a recognition site for interaction with the AP1 adaptor co

111 ein homology models that predict a plausible recognition site for lysophosphatidylcholine only in EcN

112 resence of both a PUM recognition site and a recognition site for preferentially co-occurring miRNAs

113 The cyclin groove is an important recognition site for substrates of the cell cycle cyclin

114 vious biochemical studies suggested that the recognition site for TBZ and monoamines is different.

115 ted that the C terminus of PspC might be the recognition site for the FtsH protease and an interactio

116 dulated by changing the affinity of a remote recognition site for the interlocked crown ether ring th

117 ary and tertiary structure can also act as a recognition site for the transcription factor in a proce

118 methylome analysis was used to identify the recognition site for three key N. meningitidis methyltra

119 This strategy allowed us to map the recognition site for twin arginine signal peptides to th

120 This motif contains the consensus recognition sites for CK2 (SXXE), glycogen synthase kina

121 luster domain CCCCAACTCCTT with different 3' recognition sites for complementary oligonucleotides.

122 p accurate models of variation affecting the recognition sites for diverse transcription factors and

123 al fraction of regulatory DNA bases encoding recognition sites for each TF has been strictly conserve

124 IP) nanoparticles including highly selective recognition sites for fluoxetine were synthesized, utili

125 tes were enriched within 50 nts from the RBP recognition sites for PUM and UAUUUAU.

126 d two unmethylated CpG sites, which are also recognition sites for Sau96I and SacII, and is attached

127 Recognition sites for some of these RBPs tended to local

128 ates for chromophoric silver clusters and as recognition sites for target DNA strands, and communicat

129 eucine motifs, NPXY) that serve as universal recognition sites for the AP-2 adaptor complex or other

130 17 precede a proline, making them potential recognition sites for the peptidyl-prolyl isomerase Pin1

131 rich tetrathiafulvalene and dioxynaphthalene recognition sites for the ring component (namely, a tetr

132 The structures reveal two novel recognition sites for the small-molecule modulators corr

133 with tetrathiafulvalene and dioxynaphthalene recognition sites for the tetracationic cyclophane, and

134 g of two nucleic acid scaffolds that include recognition sites for the two genes and replication trac

135 of two different circular DNAs that include recognition sites for two different target genes, comple

136 mains in the plasma membrane that constitute recognition sites for vesicle docking.

137 been engineered to carry an array of unique recognition sites for ZFNs and homing endonucleases and

138 sites was predicted to release nearby miRNA recognition sites from RNA secondary structures.

139 integrases (and their cognate attB and attP recognition sites), from which we build 11 memory switch

140 Upstream activating sequence (UAS) Gal4 recognition sites harbored on recipient plasmids were pr

141 genes in the hemiascomycetes because its DNA recognition site has evolved with it, preserving the pro

142 usands of transgenic insertions carrying SSR recognition sites have been distributed throughout the g

143 ns harbor multiple transcription factor (TF) recognition sites; however, the contribution of individu

144 The recognition site hybridizes with complementary oligonucl

145 fied the Ii adjuvant by insertion of a furin recognition site (Ii-fur) to obtain a secreted version o

146 ication and characterization of an n-alkanol recognition site in a member of the voltage-gated TM6 ch

147 ture allows identification of a putative Chi-recognition site in an inactivated helicase domain of th

148 stent with studies suggesting that the MMP-1 recognition site in heterotrimeric collagen I is partial

149 Disrupting the NAD+ recognition site in the BRCT domain impairs non-homologo

150 nces flanking the I-SceI homing endonuclease recognition site in the center of an intron artificially

151 ed on the evolutionary conservation of their recognition sites in 3'UTRs as the binding motifs for Pu

152 ic modulators are among the strongest ligand recognition sites in a large fraction of GPCRs and sugge

153 C) and a requirement for DNA cleavage of two recognition sites in an inverted head-to-head repeat.

154 the occurrence of both classes of Fkh domain recognition sites in association with binding sites for

155 ependent unbinding kinetics from chromosomal recognition sites in both their apo and holo forms.

156 ycle-regulated genes, and shares hundreds of recognition sites in common with known master regulators

157 ajor conformational change exposing receptor recognition sites in each of its four subunits.

158 (TFs) control gene expression by binding DNA recognition sites in genomic regulatory regions.

159 om three widely separated high-affinity DnaA recognition sites in oriC.

160 A microfragments released from individual TF recognition sites in regulatory DNA, to the surrounding

161 leotides residing between adjacent POT1-TPP1 recognition sites in single-stranded telomere DNA that a

162 concentration of free galectin carbohydrate recognition sites in solution.

163 We identified recognition sites in the 3' untranslated region of Twist

164 first and given sufficient time to methylate recognition sites in the bacterial genome before the tox

165 ng provided a very well defined locations of recognition sites in the MIP molecular cavities.

166 requires the presence of both Smad and AP-1 recognition sites in the promoter.

167 al that Sox9 protein dimers bind to multiple recognition sites in the SOM sequence and are thereby bo

168 emplate, (3) selection of restriction-enzyme recognition sites in the spacer between the TAL monomer

169 s R and R' that contain -CH(2)NH(2)(+)CH(2)- recognition sites in their dumbbell components have been

170 re known, recent evidence suggests that DnaA recognition sites, in multiple genomic locations, also p

171 arginine residues that compose the protease recognition site increases on cleavage of F protein.

172 ge genomic segment that lies between two SSR recognition-site insertions can be "captured" as a targe

173 Given the high density of SSR recognition-site insertions in Drosophila, our method af

174 cal cation as three very different potential recognition sites, interlocked mechanically with the tet

175 We propose that these substrate-recognition sites, interspersed among flexible, disorder

176 e variations flanking an I-SceI endonuclease recognition site into I-SceI expressing Drosophila embry

177 Introduction of two specific recognition sites into the primary sequence of the polyp

178 (five or more rotatable bonds separating the recognition sites), intramolecular H-bonding is favored,

179 Instead the TCR recognition site involved the neck region phosphate that

180 e of uracils either within or outside of the recognition site is detrimental for binding with SRSF1.

181 ggest that an alpha helix containing the ATM recognition site is disrupted in the serine isoform of R

182 he N domain of Escherichia coli Lon, and the recognition site is identified by cross-linking and scan

183 As LacI binds tightly to its recognition site (LacO) in vitro with a Kd about 10 pico

184 TF) function by binding to short 6-10 bp DNA recognition sites located near their target genes, which

185 is over-represented in many protein-protein recognition sites, making the methyl group of this resid

186 the tree of life, suggesting that this heme recognition site may be employed by many different group

187 ds into a naive host with unmodified genomic recognition sites, methyltransferase should be synthesiz

188 chemical sensors with specifically patterned recognition sites might be realized across a single grap

189 arget analytes to their fragments' cavities (recognition sites) modulated the selective aggregation o

190 tively, we find that Dam travels between its recognition sites most efficiently when those sites are

191 the CT-alpha-syn that lacked the 118-126 aa recognition site needed for antibody binding.

192 ne substitutions (Mt-YAP5SA) in LATS1 kinase recognition sites not only resists degradation but also

193 luorescent sensor containing an 18-base pair recognition site of a homing endonuclease (I-SceI), whic

194 platelet inhibitors act by occupying the RGD recognition site of alpha(IIb)/beta(3) integrin (GPIIb/I

195 occupy additional sites within the substrate recognition site of BRD4(1).

196 no acid (AA) mismatches (MMs) at the antigen recognition site of HLA molecules represent independent

197 The principle recognition site of MAP kinases, the common docking (CD)

198 The recognition site of partial complex 1 can be completed b

199 The substrate recognition site of Pin1 performs specific and nonspecif

200 ins contained the lipoprotein signal peptide recognition site of signal peptidase II (SpII).

201 oves the formation of a proficient substrate recognition site of TatC.

202 at positions 33 to 45, corresponding to the recognition site of the beta-catenin destruction complex

203 ate and nitrite complexation at the triamide recognition site of the receptor.

204 f capsids from AAV serotypes and homology of recognition sites of AAV Nab located on different capsid

205 However, due to the similarity between recognition sites of enantiomers and common conformation

206 tein from this region, we identified the R-M recognition sites of four of these S-proteins using SMRT

207 haracterized immune-dominant IgE- and T-cell-recognition sites of Phl p 5.

208 determine the overall structure and specific recognition sites of small molecules or proteins.

209 dues, notably Arg15 and Arg16, which are the recognition sites of the kinases phosphorylating at Ser1

210 e exclusion chromatography shows that the 3' recognition sites of the single-stranded conjugates hybr

211 The recognition sites of these enzymes generally require two

212 red to the kidney obstructs the carbohydrate recognition site on CL-11 thereby reducing complement-me

213 Identification of a specific recognition site on PrP(C) that traps Abeta in an oligom

214 d that the alkyl side chains of the viologen recognition site on the molecular axle act as strict kin

215 We defined the recognition site on VP6 as a quaternary epitope containi

216 MCC inhibits the APC/C by obstructing degron recognition sites on Cdc20 (the substrate recruitment su

217 uences of the MCC subunit BubR1 block degron recognition sites on Cdc20, the APC/C coactivator subuni

218 e bimodal configuration to mask key cellular recognition sites on dsRNA.

219 aneous utilization of two distinct substrate recognition sites on Lon, an HspQ binding site and an Hs

220 t specifically bind acetyl-lysine containing recognition sites on proteins.

221 ule biophysical methods that FokI aligns two recognition sites on separate DNA molecules in parallel

222 NA triplex and a repressor protein to distal recognition sites on supercoiled DNA minicircles using M

223 unctions by either forming or masking glycan recognition sites on the cell surface or secreted glycoc

224 t occurs when Type I enzymes bind unmodified recognition sites on the host genome.

225 in terms of their ability to bind to the BH3-recognition sites on two partner proteins, Bcl-x(L) and

226 igh degree of sequence variability, antibody recognition sites or antigenic hotspots on AAVs and othe

227 ctive, catalytically active, or redox-active recognition sites, or even charges and dipoles.

228 rtion of mutations, insertion of recombinase recognition sites, or large DNA elements.

229 dimeric IRF-3 bound to the PRDII-PRDI tandem recognition sites placed at the middle of a 300 bp DNA p

230 lso not known whether all high-affinity DnaA recognition sites play an equivalent role in oligomer fo

231 t that binding of such a dimer to its tandem recognition sites PRDIII and PRDI, which are located on

232 across the antiparallel recombinase-specific recognition sites present in recombinase-dependent desig

233 The simultaneous presence of two recognition sites produces a small-amplitude macrocycle

234 se of fluorescence-tagged CBMs with specific recognition sites provided a quantitative way to elucida

235 p to 4+ and simultaneously generated two new recognition sites (pyridinium motifs) that are in compet

236 reassociate with it, and diffuse back to the recognition site rather than bind to an oligonucleotide

237 However, their recognition site remains active upon complexation with t

238 ite, which contain long tracts of degenerate recognition-site repeats.

239 a LSD1 expression vector lacking the miR-137 recognition site rescued miR-137-induced precocious diff

240 f the receptor at Arg-46 and Arg-41 protease recognition sites, respectively.

241 Placement of Pyrrolo-dC within the DNA recognition site results in a fluorescence increase when

242 The DNA contacts at the 5-base pair recognition site results in dramatic DNA distortions inc

243 d M(m), each equipped with a carboxylic acid recognition site, results in the formation of a series o

244 ne resolvase CinH recombinase (CinH) and its recognition sites RS2 were constructed and transformed i

245 equence conservation that serve as substrate-recognition sites San1 uses to target its different subs

246 ces is a recognized important feature of the recognition site search process.

247 A pair of TALENs binds to two DNA recognition sites separated by a spacer sequence, and th

248 rries tandem copies of exon 2, with an ISceI recognition site situated between them.

249 ils and monomers, HSA targets key Abeta self-recognition sites spanning the beta strands found in cro

250 ected by a decapeptide containing a protease recognition site specific for factor Xa, thrombin, or ca

251 TCC blocking activity and the existence of a recognition site specific for this scaffold.

252 hr498 --> Ser498 substitution in a substrate recognition site (SRS).

253 Identification and mapping of critical recognition sites suggest that ATR1 detection by the RPP

254 s, whereas these other members require their recognition sites, suggesting a hierarchy where these fa

255 to a merocyanine species activating a second recognition site, suitable for the formation of a pseudo

256 ts in the product pool that incorporate both recognition sites, T(p) and T(m), are self-replicators t

257 he long-distance interaction between the two recognition sites takes place.

258 main that complexes silver clusters and a 3'-recognition site that hybridizes with a target oligonucl

259 tains a unique KpnI restriction endonuclease recognition site that is not present in otherwise wild-t

260 hat the A1 domain of VWF contains a receptor-recognition site that plays a key role in regulating the

261 ains the tag of interest flanked by two gRNA recognition sites that allow excision of the tag from th

262 stems in part from mutations to restriction recognition sites that disrupt data generation, an addit

263 uman erythroid enhancer, revealing single TF recognition sites that gate the majority of downstream r

264 short or long and each bearing complementary recognition sites-that react pairwise through 1,3-dipola

265 Upon association of the target with its recognition site, the sensor strand opens to expose the

266 the other, tetrathiafulvalene and butadiyne recognition sites--the values for K are orders (one and

267 alectin-3 entail binding of its carbohydrate recognition site to glycans of a glycoprotein, resulting

268 ns span a path about 185 A long from the Chi recognition site to the nuclease active site.

269 d U1 small nuclear ribonucleoprotein (snRNP) recognition sites to be the most depleted and enriched s

270 alogen bonding iodo-triazolium station anion recognition sites to form a unique 1:1 stoichiometric ni

271 by using proteases with mutually orthogonal recognition sites to modulate brush height in situ to pr

272 quinolines by overlapping and nonoverlapping recognition sites to which murine loss-of-function mutat

273 by a clipping strategy around each and every recognition site using equimolar amounts of 2,6-pyridine

274 t transcript decay, with the rescue of miRNA recognition sites via RBP binding as one possible mechan

275 d molecular beacon (MB) with an endonuclease recognition site was designed for strand cycle amplifica

276 To address this issue, a furin recognition site was located between the ODD domain and

277 -occurring miRNAs, binding of the RBP to its recognition sites was predicted to release nearby miRNA

278 A specific group of miRNA recognition sites were enriched within 50 nts from the R

279 IP-QDs) with customized selective artificial recognition sites were fabricated in this study by optim

280 d substituted with both neutral and cationic recognition sites, were shown to be effective receptors

281 ear plasmid DNA containing two terminal loxP recognition sites when packaged in vitro.

282 e of a handful molecules that can expose new recognition sites when undergoing force-induced mechanic

283 uctures, and we propose a putative phosphate recognition site where a chloride ion is coordinated nea

284 challenged to digest DNA duplexes containing recognition sites where individual Cs and Gs were replac

285 ly amplified by the DNA regions flanking the recognition site, which contain long tracts of degenerat

286 nhibits CN by occupying a critical substrate recognition site, while leaving the catalytic center ful

287 y by recoding the gene sequence to eliminate recognition sites, while preserving the amino acid seque

288 recombining donor plasmids bearing the attB recognition site with introduced genomic attP sites or e

289 rs the advantage of large number of specific recognition sites with tailored geometry, as the resulta

290 This host combines two isophthalamide anion recognition sites with two unusual "half-crown/two carbo

291 ies can be trapped in a DNA domain without a recognition site, with a non-specific DNA association li

292 hus involve two A(2)B units, each bound to a recognition site, with two more A(2)B units bridging the

293 ent redox states among these three potential recognition sites, with corresponding color changes, is

294 e essential exoribonuclease RNase D, and its recognition site within RNase E is identified.

295 The importance of the location of the recognition site within the DNA sequence is discussed.

296 t correlation between the number of cleavage recognition sites within a given transcript and its susc

297 l activation of PKA as it occludes C-subunit recognition sites within CBD-A.

298 er these data located novel differential RNA recognition sites within neighboring domains of herpesvi

299 d from rebinding due to incorporation of its recognition sites within nucleosomes.

300 aA, bound to specific high- and low-affinity recognition sites within the unique oriC locus, comprise