ライフサイエンスコーパス: recombinase

1 n-of-function mutation is dependent upon Cre recombinase.

2 gene requires the presence of exogenous Cre recombinase.

3 ckout mice with expression of Mx1 or Vav Cre-recombinase.

4 homologous recombination by activating RAD51 recombinase.

5 ay using a reporter that is activated by Cre recombinase.

6 light-and-chemical regulated versions of Cre recombinase.

7 d by the DNA damage checkpoint and the Rad51 recombinase.

8 e earliest steps in the evolution of the RAG recombinase.

9 ain (N-DBD) stimulates the function of RAD51 recombinase.

10 MULE, hAT and Transib elements and the V(D)J recombinase.

11 ce transduced with adenovirus expressing Cre recombinase.

12 ation of Abl and bRaf kinases as well as Cre recombinase.

13 as RecA from DNA in its capacity as an anti-recombinase.

14 eflecting properties that are unique to each recombinase.

15 Mice were given tamoxifen to induce Cre recombinase.

16 ta-isoform of BCCIP in relation to the RAD51 recombinase.

17 ion are activated only after exposure to Cre recombinase.

18 tic resistance genes or enzymes, such as Cre recombinase.

19 ical voltage sensor under the control of Cre recombinase.

20 eted to the early DCT using a DCT-driven Cre recombinase.

21 ly, can be conditionally expressed using Cre recombinase.

22 upted in 2 different strains of mice via cre recombinase.

23 bination in bacteria is mediated by the RecA recombinase.

24 stored to wild type by gene editing with Cre recombinase.

25 en intrinsic flexibility and function in Cre recombinase.

26 he transformation of RAG from transposase to recombinase.

27 -Smn) can be conditionally deleted using Cre recombinase.

28 ion of an adjacent base triplet by all three recombinases.

29 tructures and those of other int-superfamily recombinases.

30 tions by combining orthogonal integrases and recombinases.

31 DNA specificities of orthologous Dre and Cre recombinases.

32 he evolutionary progenitors of the RAG1-RAG2 recombinase(2), an essential component of the adaptive i

33 on of human KIR2DS4(+) NK cells in bacterial recombinase A (RecA).

34 On exposure to cre-recombinase a stop codon is generated immediately downst

35 ptive immunity relies on the RAG1/RAG2 (RAG) recombinase, a domesticated transposase, for assembly of

36 aptic circuit, we constructed a panel of Cre recombinase-activated pseudorabies viruses (PRVs) that e

37 melioration of pathology was observed in the recombinase-activating gene 2 KO mice.

38 Mutations in the recombinase-activating genes cause severe immunodeficien

39 These results indicate that the anti-recombinase activity of BLM is of general importance for

40 tometry-based assay, we aimed to measure the recombinase activity of naturally occurring RAG2 mutant

41 ith RAD51, and that BRCA1-BARD1 enhances the recombinase activity of RAD51.

42 of UAF1 is indispensable for enhanced RAD51 recombinase activity within the context of the UAF1-RAD5

43 Mice with albumin promoter-driven Cre recombinase (Alb-Cre)-mediated or AAV8-mediated L-Fabp d

44 O) mouse lines, with viral expression of Cre-recombinase and a light-activated ion channel for optica

45 ts suicide inside host cells by inducing Cre recombinase and deleting essential genes flanked by loxP

46 ne the role of PDGFR-alpha in HSCs, Lrat-Cre recombinase and Pdgfra-floxed mice were bred to generate

47 o-associated virus [AAV]) that expresses Cre recombinase and sgRNAs targeting Rb1, Tp53, and Rbl2 int

48 oncogene (KRAS), achieved by delivering Cre recombinase and sgRNAs, which caused rapid lung tumor de

49 They co-occurred with a strictly conserved recombinase and transposon Tn3 family but with a differe

50 f two unrelated genome editing proteins, Cre recombinase and zinc-finger nucleases, under conditions

51 agents-nucleases, base editors, transposases/recombinases and prime editors-are currently available f

52 conceptually works as an unlimited number of recombinases and will facilitate genetic access to cell

53 o achieve tight inducible control of Cre DNA recombinase, and provides general guidelines for further

54 and functional analyses in a sequential dual-recombinase approach that creates mosaic Pdgfr mutant ce

55 Dmc1 recombinases are essential to homologous recombination i

56 Flp-TAL recombinases are hybrid enzymes that are composed of two

57 Site-specific DNA recombinases are important genome engineering tools.

58 However, inducible recombinases are scarce due to the challenge of engineer

59 Other diagnostic platforms including RT- recombinase assisted amplification (RT-RAA) and SAMBA-II

60 esent the development of chassis-independent recombinase-assisted genome engineering (CRAGE), which e

61 and validate the protective capability of a recombinase-associated AID subtype (rAID-1) that is pres

62 and exchange mechanisms of three RecA-family recombinases, bacterial RecA, and eukaryotic Rad51 and D

63 we created light-inducible site-specific DNA recombinases based on Cre, Dre and Flp (RecVs).

64 re we develop a genetic strategy combining a recombinase-based intersectional labeling method and rab

65 t greatly enhance the capabilities of a Bxb1 recombinase-based landing pad system for conducting diff

66 Using bone marrow transplantation and Cre recombinase-based lineage tracing experiments, we rule o

67 describe the development and validation of a recombinase-based lineage tracing system for the chicken

68 Here, we have taken advantage of Cre/loxP recombinase-based strategy to conditionally delete Cc2d1

69 ed V(D)J recombination that involves the RAG recombinase binding and cutting recombination signal seq

70 f-SNAPf-Halo2) that are activated by the DNA recombinase Bxb1.

71 demonstrate the functionality of the Flp-TAL recombinases by performing integration and deletion expe

72 triphosphate (ATP) the human RAD51 (HsRAD51) recombinase can form a nucleoprotein filament (NPF) on d

73 The broadly conserved Rad51/RecA family of recombinases catalyzes the DNA strand invasion reaction

74 developed Sparse Predictive Activity through Recombinase Competition (SPARC), a generalizable toolkit

75 g cutting, the RSS is released while the ESC-recombinase complex remains intact to potentially trigge

76 d by the recombination-activating gene (RAG) recombinase, consisting of RAG-1 and RAG-2 subunits.

77 recombination-activating gene protein (RAG) recombinase, consisting of RAG-1 and RAG-2 subunits.

78 the lung by nasal delivery of adenoviral Cre recombinase (Cre), here we show that KRAS(G12D) expressi

79 In this study, we used the Cre recombinase (Cre)-loxP system under regulation of the mo

80 y of mice expressing tamoxifen-inducible Cre recombinase (Cre-ERT2) under the Aicda promoter crossed

81 generated mice with tamoxifen-inducible Cre recombinase (CreERT2) in the Anxa10 gene locus.

82 .Foxo1 (L/L) mice with lineage-specific Cre recombinase deletion of floxed FOXO1 and compared the re

83 an insulin receptoropathy in mice, using Cre recombinase delivered by adeno-associated virus to knock

84 ed by off-target, or "leak" expression, from recombinase-dependent AAVs.

85 e or Flp recombinases in defined cell types, recombinase-dependent adeno-associated viruses (AAVs) ha

86 Cre recombinase-dependent Ai9 reporter mice were crossed wit

87 binase-specific recognition sites present in recombinase-dependent designs.

88 gene expression and are extremely useful for recombinase-dependent expression of highly sensitive tra

89 be within a locus designed for efficient Cre recombinase-dependent expression.

90 ne MN-enriched miRNA expression, we used Cre recombinase-dependent miRNA tagging and affinity purific

91 as9 to facilitate use of the dimerisable Cre-recombinase (DiCre) that is frequently used to mediate t

92 Using male mice with Cre-recombinase directed to the oxytocin receptor gene (Oxtr

93 m consists of Rad51 and the meiosis-specific recombinase Dmc1.

94 arker into the VTA of male mice that had Cre-recombinase driven by OTR gene expression.

95 -1alpha floxed mice with mice expressing Cre-recombinase driven by the calcium/calmodulin-dependent p

96 titutive activation of betacatenin using cre recombinase driven by the DEAD (Asp-Glu-Ala-Asp) box pro

97 ic inactivation of the BBSome induced by Cre recombinase driven by the rhodopsin promoter.

98 was deleted using a tamoxifen-inducible Cre recombinase driven by the ubiquitously expressed ROSA26

99 Our design is based on standardized recombinase-driven DNA scaffolds expressing different ge

100 tex at different prenatal ages using two Cre-recombinase driver lines.

101 d two different mature RPE cell-specific Cre recombinase drivers to inactivate either Dicer1 or DiGeo

102 visiae, is well-known for its role with Dmc1 recombinase during meiotic recombination.

103 -associated virus-mediated expression of cre recombinase, eliminated cocaine-induced ERK phosphorylat

104 esistance qacA gene, the cassette chromosome recombinase-encoding genes ccrA and ccrB, and the IS256-

105 3/HDMX complexes in living cells using a new recombinase enhanced bimolecular luciferase complementat

106 other tumor suppressor proteins and with the recombinase enzyme RAD51 to mediate chromosome damage re

107 n of cKOs by local viral delivery of the Cre-recombinase enzyme.

108 because they expressed a high amount of Cre recombinase exclusively in ameloblasts and showed develo

109 The Rad51 (also known as RecA) family of recombinases executes the critical step in homologous re

110 nchored Independent Labeling, to isolate Cre recombinase-expressing (Cre(+)) nuclei from the adult mo

111 rons chemogenetically using a retrograde Cre-recombinase-expressing canine adenovirus-2 in combinatio

112 sts with 2 different tamoxifen-inducible Cre recombinase-expressing gene-targeted mouse lines.

113 Using a Cre recombinase-expressing IAV, we have previously shown tha

114 cuit performance declines with a decrease in recombinase expression and new experimental data was gen

115 tor fate restriction signals to constitutive recombinase expression enables viral targeting of cell t

116 VGLUT2 may be exploited to drive robust Cre recombinase expression in RGCs without any expression ob

117 em largely depends on the specificity of Cre recombinase expression in targeted stem or progenitor ce

118 sectional fate mapping approach in which Flp recombinase expression is both dependent on Cre and rest

119 e new rat strains (Cre drivers) in which Cre recombinase expression is carefully controlled temporall

120 ere crossed with DAT-Cre mice, in which Cre- recombinase expression is under dopamine transporter gen

121 osteocytes, no differences in Mbtps1 or cre recombinase expression were observed in cKO SOL, explain

122 and reversible transgene manipulation, VCre recombinase expression, and transgenesis of human cells.

123 After Cre recombinase expression, GsD is activated temporally by t

124 rom transgenic mice with region-specific Cre recombinase expression.

125 The RAD51 recombinase facilitates DNA joint formation during HR, b

126 modules: a variant of site-specific tyrosine recombinase Flp, which can have either narrow or broad t

127 d glial fibrillary acidic protein (GFAP)-FLP recombinase (FLPo) mice that express FLPo recombinase sp

128 Using a dual recombinase fluorescent reporter strategy, we showed tha

129 We quantitatively characterize the inducible recombinases for benchmarking their performances, includ

130 e acquisition of a monomer of activated RecA recombinase, forming Pol V Mut.

131 last enhancers drive expression of split Cre recombinase fragments.

132 single strand annealing proteins (SSAPs) are recombinases frequently encoded in the genome of many ba

133 chemogenetics in male rats that express Cre recombinase from a Crh promoter.

134 mouse lines that express improved Cre (iCre)-recombinase from the locus of the mouse ameloblast-speci

135 Here, we generated mice expressing Cre recombinase from the Robo3 locus specifically in commiss

136 The RecA recombinase functions to mediate repair via homologous D

137 accessory proteins enhance separation of the recombinases' functions during meiotic HR.

138 ed deletion of gata3 driven by otoferlin-cre recombinase (gata3(fl/fl) otof-cre(+/-) ) in IHCs does n

139 Both recombinases have distinct activities during meiotic HR,

140 ecombination, the synaptic intermediate is a recombinase homotetramer containing a pair of loxP DNA t

141 ce the tumor is induced by activation of Cre-recombinase in a tissue-specific manner, further genetic

142 tamic acid decarboxylase (GAD67-GFP), or Cre-recombinase in cells that contain glutamic acid decarbox

143 active (Y324F) mutant of this engineered Tre recombinase in complex with the loxLTR DNA substrate.

144 The Ntsr1-Cre GN220 mouse expresses Cre-recombinase in corticothalamic (CT) neurons in neocortic

145 le and female transgenic mice expressing Cre recombinase in FSIs allowed us to identify these sparsel

146 ng adeno-associated virus that expressed Cre-recombinase in HIF-1alpha floxed mice.

147 gins by stereotactic viral expression of Cre-recombinase in hippocampal CA1 region pyramidal neurons

148 dated a transgenic mouse line expressing cre recombinase in histidine decarboxylase-expressing neuron

149 buted to its role as a mediator of the RAD51 recombinase in HR repair of programmed DNA double-strand

150 used to specifically and inducibly drive Cre recombinase in ICC as a strategy to study GIST pathogene

151 ines (including both sexes) that express Cre-recombinase in MCs.

152 ice with a knock-in mouse expressing the Cre recombinase in the CD45 locus.

153 We observe a broad expression of Cre recombinase in the Gfi1(Cre) mouse neonatal inner ear, p

154 atous polyposis coli) upon expression of CRE recombinase in the liver and monitored their effects on

155 ession in the NAc of mice transgenic for Cre recombinase in these MSN subtypes.

156 Amhr2-Cre mice express Cre recombinase in tissues that develop into the fallopian t

157 r the Escherichia coli Rep helicase and RecA recombinase in tolerating toxicity induced by G4-stabili

158 equently used to drive expression of the Cre recombinase in tuft cells.

159 transgenic mouse lines expressing Cre or Flp recombinases in defined cell types, recombinase-dependen

160 Chemical- and light-inducible recombinases, in particular, enable spatiotemporal contr

161 edict off-target substrates of Tre and Brec1 recombinases, including endogenous human genomic sequenc

162 lopment of a transgenic mouse line where Cre-recombinase-induced expression of a mutant methionyl-tRN

163 e platform, termed Lm-RIID (L. monocytogenes recombinase-induced intracellular death), that induces t

164 A transgenic mouse containing a CRE-recombinase inducible CAG promoter driven CD9 protein fu

165 constitutively active Eef1a1 locus in a Cre recombinase-inducible manner.

166 adult Mx1-cre(+)Raptor(fl/fl) mice upon cre-recombinase induction.

167 HK022 coliphage site-specific recombinase Integrase (Int) can catalyze integrative sit

168 o-hybrid method, CrY2H-seq, which uses a Cre recombinase interaction reporter to intracellularly fuse

169 used to deliver the biologically active Cre recombinase into a loxP-reporter T cell line.

170 ntroduction of transgenes encoding the DiCre recombinase into genomic loci dispensable for blood stag

171 MAGL via injection of virally-delivered Cre recombinase into the MSDB of Cnr1(loxP/loxP) or Mgll(lox

172 g pad versions, including one where the Bxb1 recombinase is expressed from the landing pad itself, im

173 Cre recombinase is mixed with a fluorophore-tagged polymer c

174 integrase (Int)-a large serine site-specific recombinase-is autonomous for phage integration (attP x

175 e activity and the ability to displace Rad51 recombinase, it was unclear which functions were require

176 Using either a keratin 5-Cre recombinase (K5-Cre) cross or an MMTV-NIC mouse, we inve

177 proach with our library of enhancer trap flp-recombinase lines.

178 These studies combine the use of the Cre-recombinase/loxP system in mice with optogenetics to str

179 e-specific and tamoxifen-inducible MerCreMer recombinase (MCM), 3 mouse lines (MCM/ROCK1(fl/fl)/ROCK2

180 mTERT genes and their neighboring loci, via recombinase-mediated BAC targeting.

181 Here we establish mosaic analysis by dual recombinase-mediated cassette exchange (MADR), which per

182 integrative site-specific recombination and recombinase-mediated cassette exchange (RMCE) reactions

183 We applied the Cre/lox recombinase-mediated cassette exchange (RMCE) system to

184 In addition, we developed a highly efficient recombinase-mediated cassette exchange system to facilit

185 ions tested: excision, integration, and dual recombinase-mediated cassette exchange.

186 Here, we used a Cre recombinase-mediated chromosome loss strategy to individ

187 Here, we show that Cre recombinase-mediated conditional deletion of Atp6ap2 in

188 nts in preclinical mouse models requires Cre recombinase-mediated conditional gene expression in stem

189 Panx1 (Panx1 (-/-) Apoe (-/-) ) or with Cre recombinase-mediated deletion of Panx1 in endothelial ce

190 ble lineage tracing to fate map, through Cre recombinase-mediated fluorescent reporter gene activatio

191 Here, we have used Cre-recombinase-mediated genetic labeling to identify and ma

192 Cre-recombinase-mediated knockdown and overexpression of HDA

193 ructions for setting up SHERLOCK assays with recombinase-mediated polymerase pre-amplification of DNA

194 erlapping inversions rather than transposase/recombinase-mediated processes.

195 Cre-recombinase-mediated Ptch1 ablation in mammary epitheliu

196 Regulated expression of Cre recombinase mediates precise deletion of genetic element

197 be controlled tissue-specifically using Cre recombinase mice.

198 ox-STOP-lox-miR-150 mice with WAP-driven Cre recombinase mice.

199 distinctive activity of Rad52; neither Rad51 recombinase nor the yeast Rad52 paralog Rad59 has this a

200 Upon activation with Cre recombinase ("on-state"), the intron is crippled and the

201 erograde tracing using mice that express Cre recombinase only in neurons producing acetylcholine, glu

202 o initiate recombination by loading the RecA recombinase onto DNA.

203 d in research involve knock-in (reporters or recombinases) or gene replacement (e.g., conditional kno

204 haracterize a previously developed split Cre recombinase (PA-Cre2.0) that is reconstituted upon light

205 enetically encoded photoactivatable (PA) Cre recombinase, PA-Cre 3.0.

206 Pam (0-Cre-cKO/cKO) atrial myocytes (no Cre recombinase, PAM floxed) were transduced with Cre-GFP le

207 During meiosis many eukaryotes utilize a two-recombinase pathway.

208 The Platelet factor 4-Cre recombinase (Pf4-Cre) transgenic mouse is the current mo

209 e Plasmodium falciparum, we investigated its recombinase, PfRad51, as a potential drug target.

210 ance of genome stability, in which the RAD51 recombinase plays a central role.

211 tic test for SARS-CoV-2 based on an enhanced recombinase polymerase amplification (eRPA) reaction.

212 An isothermal heterogeneous asymmetric recombinase polymerase amplification (haRPA) was carried

213 In the DAMR system, recombinase polymerase amplification (RPA) and CRISPR-Ca

214 ed test, two rapid molecular assays based on recombinase polymerase amplification (RPA) for the detec

215 While rapid isothermal strategies such as recombinase polymerase amplification (RPA) have been pro

216 Recombinase polymerase amplification (RPA) is a novel is

217 ion of DNA amplification using an isothermal Recombinase Polymerase Amplification (RPA) method.

218 Solid-phase isothermal recombinase polymerase amplification (RPA) offers many b

219 In a principle study, on-chip recombinase polymerase amplification (RPA) on defined sp

220 isothermal DNA amplification assay based on recombinase polymerase amplification (RPA) was developed

221 Recombinase polymerase amplification (RPA), an isotherma

222 ns produced by standard RT-PCR or isothermal recombinase polymerase amplification (RPA), to allow sen

223 d detection of Salmonella-specific DNA using recombinase polymerase amplification (RPA).

224 methods, an isothermal reverse transcription-recombinase polymerase amplification and lateral flow as

225 lude loop-mediated isothermal amplification, recombinase polymerase amplification, rolling circle amp

226 disrupting ssDNA intermediates bound by the recombinase protein Rad51.

227 or translocate on ssDNA that is bound by the recombinase protein RAD51.

228 ism, which proceeds along nucleofilaments of recombinase proteins of the RecA family.

229 ignal circle (ESC), forms a complex with the recombinase proteins to efficiently catalyze breaks at s

230 hance homologous DNA pairing mediated by the recombinase RAD51 in DNA repair via the homologous recom

231 elieved meiotic inhibition of the ubiquitous recombinase Rad51, suggesting that the mitotic recombina

232 RPA is then replaced by the DNA recombinase Rad51, which forms extended helical filament

233 by either replication protein A (RPA) or the recombinase Rad51.

234 our suppressor complex, BRCA2-PALB2, and the recombinase RAD51.

235 ns and the recruitment and regulation of the recombinase RAD51.

236 d a reduced number of the foci formed by the recombinases RAD51/DMC1, thus leading to a lower frequen

237 RAD51 recombinase (RAD51) is a critical component of HR and fa

238 licase-interacting protein 1 (WRNIP1), RAD51 recombinase (RAD51), and BRCA2 DNA repair associated (BR

239 vast majority of eukaryotes possess two DNA recombinases: Rad51, which is ubiquitously expressed, an

240 amage-induced splicing, in which an archaeal recombinase RadA intein splices dramatically faster and

241 n in a genome) to give rise to the RAG1-RAG2 recombinase (RAG) and V(D)J recombination, which produce

242 The RAG1-RAG2 recombinase (RAG) cleaves DNA to initiate V(D)J recombin

243 The RAG recombinase (RAG1/2) plays an essential role in adaptive

244 of Kras(G12D) (LSL-Kras(G12D)) via Cre(ERTM) recombinase regulated by an acinar cell-specific promote

245 knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional a

246 radely transported AAV vector expressing Cre recombinase (Retro-Cre-GFP) into the BLA (Experiment 1)

247 eloped a recombinant JHMV that expresses Cre recombinase (rJ-Cre) and infected mice that universally

248 neering include that, whenever possible, the recombinase should act independent of cofactors and that

249 mediated by homology across the antiparallel recombinase-specific recognition sites present in recomb

250 LP recombinase (FLPo) mice that express FLPo recombinase specifically in GFAP-positive cells.

251 these findings, we propose a model in which recombinase specificities for meiotic accessory proteins

252 The development of site-specific recombinases (SSRs) as genome editing agents is limited

253 These dual recombinase system (DRS) approaches will enable scientis

254 ng tenocytes using a tamoxifen-inducible Cre-recombinase system and caused tendon growth in adult mic

255 Tamoxifen (TAM) inducible Cre recombinase system is an essential tool to study gene fu

256 The evolutionary origins of this two-recombinase system remain poorly understood.

257 Similar principles apply to other recombinase systems and other genetically targeted organ

258 acing technology, using a combination of two recombinase systems, Dre/RoxP and Cre/LoxP, to independe

259 Replacement of V(D)J recombinase targets at two different mouse Vbeta gene se

260 rced genetically by the low quality of Vbeta recombinase targets that stochastically restrict the pro

261 eered mouse models that employ site-specific recombinase technology are important tools for cancer re

262 sarcomas generated with CRISPR-Cas9 and Cre recombinase technology had similar histology, growth kin

263 Here we used dual recombinase technology in a primary murine lung cancer m

264 compare to tumours generated by conventional recombinase technology remains to be fully explored.

265 he current study we used CRISPR/Cas9 and Cre recombinase technology to produce mice that lack GH rece

266 a library of >20 orthogonal inducible split recombinases that can be activated by small molecules, l

267 describe here the development of the Flp-TAL recombinases that can target genomic FRT-like sequences

268 The site-specific recombinase Tn3 resolvase initiates DNA strand exchange

269 lity was mimicked with viral delivery of Cre recombinase to astrocytes in the LHA and rescued by in v

270 After viral delivery of Cre recombinase to hepatocytes in vivo, GsD is expressed and

271 age analysis has been accomplished using Cre recombinase to indelibly label a defined progenitor popu

272 s with a high efficiency of 60% and used Flp recombinase to restore expression in two null cell lines

273 e used Cre driver lines (mice expressing Cre recombinase) to comprehensively and selectively label br

274 Cell type-specific tamoxifen-inducible Cre recombinase transgenes were used to target glioblastoma-

275 We used SMC- and EC-specific Cre recombinase transgenes with a novel floxed Eln allele to

276 tional knockout [cKO]) when crossed with Cre recombinase transgenic mice.

277 Furthermore, using different Cre-recombinase transgenic mouse strains to specifically tar

278 was conditionally deleted in B cells by Cre recombinase under control of the Mb1 gene in Spib (encod

279 ed mice that express tamoxifen-inducible Cre recombinase under control of the Plp1 promoter and carry

280 ng mice expressing a tamoxifen-dependent Cre recombinase under the control of a fibroblast-specific p

281 The Fsp1-Flpo allele consists in the Flpo recombinase under the control of the Fsp1 (fibroblast-sp

282 crossed with transgenic mice expressing Cre recombinase under the control of the mouse platelet fact

283 s vectors and transgenic mice expressing Cre recombinase under the D1 promoter, we also found that D1

284 of Trim33 by combining floxed Trim33 and Cre recombinase under the Pax7 promoter.

285 ability of BLADE arises from its reliance on recombinases under the control of a single promoter, whi

286 The engineered recombinase variants were found to be active in all reco

287 iated virus 8-thyroxine-binding globulin-Cre-recombinase versus control.

288 on of a BAAV vector encoding a bacterial Cre recombinase via canalostomy in adult mice with floxed co

289 rom cells, Tre, an engineered version of Cre recombinase, was designed to target a 34-bp sequence wit

290 tropism, a canine adenovirus expressing Cre recombinase, was injected into the left intermediolatera

291 Using our orthogonal inducible recombinases, we create a genetic switchboard that can i

292 ous recombination in eukaryotes is the RAD51 recombinase, which forms helical nucleoprotein filaments

293 ific DNA cleavage by the mammalian RAG1-RAG2 recombinase, which initiates V(D)J recombination, we fin

294 ally deleted using progesterone receptor Cre recombinase, which is expressed in both epithelial and m

295 ty of the antigen receptor loci to the V(D)J recombinase, which is required for these rearrangements.

296 med the ancestral RAG transposase into a RAG recombinase with appropriately regulated DNA cleavage an

297 of alleles targeted by Cas9 and traditional recombinase with single-cell specificity.

298 apidly characterizing the DNA specificity of recombinases with single-nucleotide resolution, and for

299 In Escherichia coli, two tyrosine-family recombinases, XerC and XerD, bind to dif and carry out t

300 chromosomal site, dif, by 2 related tyrosine recombinases, XerC and XerD.