ライフサイエンスコーパス: recombination repair

1 evere DNA damage is corrected via homologous recombination repair.

2 primarily dependent on ERCC1 and homologous recombination repair.

3 with a direct or indirect role in homologous recombination repair.

4 n the choice of templates used in homologous recombination repair.

5 ive G2/M checkpoint, and impaired homologous recombination repair.

6 which is critically important for homologous recombination repair.

7 processing associated with failed homologous recombination repair.

8 equently recruit Rad51 to promote homologous recombination repair.

9 cd2 foci assembly and a defect in homologous recombination repair.

10 A1 and PALB2 is important for the homologous recombination repair.

11 lication stress, suggesting a direct role in recombination repair.

12 te a direct role of RPA in homology directed recombination repair.

13 reinitiation of DNA synthesis by homologous recombination repair.

14 SSBs collapse replication forks, triggering recombination repair.

15 in EM9 causes more collapsed forks and more recombination repair.

16 ANCD2 and 10 proteins involved in homologous recombination repair.

17 pecifically involves homology-dependent (HR) recombination repair.

18 RCA2 pathways as they function in homologous recombination repair.

19 n shown to be required for homology-directed recombination repair.

20 can be overcome partially by recA-dependent recombination repair.

21 nslesion DNA synthesis, excision repair, and recombination repair.

22 family, thought to be central to homologous recombination repair.

23 complement a yeast rad51 mutant deficient in recombination repair.

24 ted break-induced replication and homologous recombination repair.

25 ction, RAD51 binding and accurate Homologous Recombination repair.

26 bitors, suggestive of a defect in homologous recombination repair.

27 RPi), despite being proficient in homologous recombination repair.

28 inase foci formation and augments homologous recombination repair.

29 amage repair signaling, impairing homologous recombination repair.

30 ubsequent removal of Rad51 during homologous recombination repair.

31 e that requires BRCA1/2-dependent homologous recombination repair.

32 end resection, the first step of homologous recombination repair.

33 on-homologous end joining but not homologous recombination repair.

34 arly ATM checkpoint responses and homologous recombination repair.

35 rocessing that is a requisite for homologous recombination repair.

36 on studies) and together, promote homologous recombination repair.

37 CTIP)-dependent end resection and homologous recombination repair.

38 in human cells causes defects in homologous recombination repair.

39 lutionarily conserved function in homologous recombination repair.

40 e strain MS11 recB mutants were assessed for recombination/repair.

41 ernative to BRCA2/RAD51-dependent homologous recombination repair(10).

42 DNA replication, a sub-pathway of homologous recombination repair activated at broken or collapsed re

43 tions trigger genomic rearrangements through recombination-repair activities.

44 ced DNA damage by attenuating DNA homologous recombination repair activity and RAD51 foci formation.

45 onstrated that TAK-931 suppressed homologous recombination repair activity, delayed recovery from dou

46 d51-dependent and BRCA2-dependent homologous recombination repair activity.

47 ival is not due to restoration of homologous recombination repair although decreased DNA damage signa

48 D51 protein (hRAD51), facilitates eukaryotic recombination/repair, although its ability to hydrolyze

49 ot SA1 decreased sister chromatid homologous recombination repair and affected repair pathway choice,

50 ctivation of this pathway rescued homologous recombination repair and allowed BRCA1-deficient cells t

51 BRCA1 promotes homologous recombination repair and antagonizes 53BP1-dependent non

52 and links BRCA1 and BRCA2 in DNA homologous recombination repair and breast cancer suppression.

53 icipation of H3K79 methylation in UV-induced recombination repair and checkpoint activation, and furt

54 R-155 decreased the efficiency of homologous recombination repair and enhanced sensitivity to IR in v

55 -helicase complex participates in homologous recombination repair and is essential for cellular prote

56 PDAC deficient in homologous recombination repair and mismatch repair is a subgroup t

57 A helicase proposed to operate in homologous recombination repair and replicational stress response.

58 functions in genome maintenance via roles in recombination repair and resolution of recombination str

59 d processing that is required for subsequent recombination repair and restart of replication forks.

60 bility and, consequently, require homologous recombination repair and the DNA damage checkpoint for v

61 f BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive to PARP inh

62 and WRN, play important roles in homologous recombination repair and they have been implicated in te

63 mination required to regulate transcription, recombination, repair and chromosome replication and seg

64 ses like transcription, DNA replication, DNA recombination, repair and modification.

65 molecular biological processes that mediate recombination, repair and replication of DNA have come f

66 iophage T4 UvsW protein is involved in phage recombination, repair and the regulation of replication

67 e active in many aspects of DNA replication, recombination, repair and transcription.

68 cellular survival and viability, homologous recombination repair, and genome instability.

69 Nucleotide excision repair, recombination repair, and highly accurate translesion sy

70 ntral role in DNA replication and homologous recombination repair, and is known to be involved in can

71 51 focus formation, inhibition of homologous recombination repair, and persistent gamma-H2AX expressi

72 including clonogenic growth, DNA homologous recombination repair, and poly-ADP ribosylase inhibitor

73 break repair, XRCC3 and RAD51 in homologous recombination repair, and XRCC7 in nonhomologous end joi

74 he DNA metabolic processes of transcription, recombination, repair, and chromatin remodeling.

75 DNA helix during replication, transcription, recombination, repair, and chromatin remodeling.

76 ny other proteins important for replication, recombination, repair, and chromosome segregation contai

77 Elucidation of DNA recombination, repair, and diversification programs in t

78 in the machinery controlling cell cycle, DNA recombination, repair, and gene expression.

79 se activities are likely to be important for recombination, repair, and genomic stability.

80 and play essential roles in DNA replication, recombination, repair, and maintenance of genomic integr

81 erase activity is essential for replication, recombination, repair, and mutagenesis.

82 d to function in the genetic pathways of DNA recombination, repair, and replication which are importa

83 iological processes including transcription, recombination, repair, and replication.

84 involved in DNA homologous and site-specific recombination, repair, and replication.

85 DNA (ssDNA) binding protein required for DNA recombination, repair, and replication.

86 junctions are critical intermediates in DNA recombination, repair, and restart of blocked replicatio

87 biological functions during DNA replication, recombination, repair, and transcription.

88 rder, displaying defects in DNA replication, recombination, repair, and transcription.

89 the primary proteins involved in homologous recombination repair are RAD51 and the five RAD51 paralo

90 involved in DNA repair, including homologous recombination repair, are associated with response to po

91 All assays, except the homologous recombination repair assay, showed statistically signifi

92 length at DSBs to the capability for global recombination repair between sister chromatids.

93 ing a sequence that could support homologous recombination repair between the two plasmids.

94 of Rad51 expression, required for homologous recombination repair, blocked the ability of mutant p53

95 s reparation of DNA lesions (e.g. homologous recombination repair), but also prolongs activation of c

96 double-strand break (DSB) during homologous recombination repair, but a role in DSB repair by nonhom

97 human Mus81-Eme1 endonuclease is involved in recombination repair, but the exact structures it acts o

98 In addition, INT3 is involved in homologous recombination repair by regulating Rad51 foci formation

99 prototypical bacterial RecA protein promotes recombination/repair by catalyzing strand exchange betwe

100 When the recombination/repair capacity of strain MS11 was compare

101 cases were enriched with RDVs in homologous recombination repair [carrier frequency (CF) = 22.9% ver

102 se that not all components of the homologous recombination repair complex can act as cancer susceptib

103 Homologous recombination repairs damage-induced DNA double-strand b

104 ped for treating tumors harboring homologous recombination repair defects that lead to a dependency o

105 reatment options for cancers with homologous recombination repair defects, especially those carrying

106 and P9 rec(+) bacteria presenting pronounced recombination/repair defects.

107 One involves homologous recombination repair deficiency (HRD) while the other is

108 d compound algorithmic scores for homologous recombination repair deficiency (HRD), mismatch repair d

109 ures in breast cancer and predict homologous recombination repair deficiency in held-out tumors.

110 lus erlotinib (MET), talazoparib (homologous recombination repair deficiency), and telisotuzumab vedo

111 umors, 59% were predicted to have homologous-recombination-repair deficiency (HRDetect-high): 67% exp

112 ational signature associated with homologous-recombination-repair deficiency.

113 non-germline BRCA1/2 mutated and homologous recombination repair deficient (HRD) tumors are likely a

114 depletion of BRCA1 and subsequent homologous recombination repair deficit was induced with either tru

115 Homologous recombination repairs DNA breaks and sequence gaps via t

116 Homologous recombination repairs DNA double strand breaks and prote

117 Homologous recombination repairs DNA double-strand breaks and must

118 Homologous recombination repairs DNA double-strand breaks by search

119 cting stressed replication forks: homologous recombination repair, DNA inter-strand cross-link repair

120 rived growth factor and the Rad51 homologous recombination repair factor at DNA breaks.

121 ed by concomitant deletion of the homologous recombination repair factor, Rhp51 (Rad51).

122 litate the functional dissection of this DNA recombination/repair factor.

123 on the XPF-ERCC1 heterodimer, and homologous recombination repair factors XRCC2 and XRCC3.

124 vage, lesser focal recruitment of homologous recombination repair factors, impaired DNA double-strand

125 pathway; radC, which encodes a RecG-like DNA recombination/repair function; malE, which is the first

126 To investigate the importance of the recombination repair functions of Ercc1 we studied sperm

127 MAGNITUDE found patients with homologous recombination repair gene alterations (HRR+), particular

128 ion-resistant prostate cancer and homologous recombination repair gene alterations who had disease pr

129 y conserved novel member of the recA / RAD51 recombination repair gene family.

130 six with stratification based on homologous recombination repair gene mutation status, progression-f

131 (block size of six, stratified by homologous recombination repair gene mutation status, progression-f

132 volved cell death/survival, DNA replication, recombination/repair, gene expression, organismal develo

133 who had qualifying alterations in homologous recombination repair genes and whose disease had progres

134 A downregulation), alterations of homologous recombination repair genes, and expression of oncogenic

135 own pathogenic alterations within homologous recombination repair genes, we find 10 patients (19.6%)

136 ining does not involve all of the homologous recombination repair genes.

137 ws dynamic epistatic interactions with other recombination-repair genes.

138 Several isogenic strains with defects in recombination/repair genes (RAD1, RAD50, RAD51, RAD52, R

139 nalyses reveal that expression levels of the recombination/repair genes RAD51, RAD52 and RAD54 can af

140 xtracts from cells carrying mutations in the recombination/repair genes RAD51C or XRCC3 have reduced

141 moter methylation, or non-BRCA1/2 homologous recombination repair germline mutations.

142 an important role in nucleotide excision and recombination repairs, has a novel role to produce GCRs.

143 n a PCa cell line impaired homology-directed recombination repair (HDR) and caused androgen-induced g

144 ed to process DNA ends for homology-directed recombination repair (HDR) and to counteract replication

145 recombinase-mediated unfaithful homeologous recombination repair (HomeoRR) in a dosage-dependent man

146 t Ape1 facilitates BRCA1-mediated homologous recombination repair (HR), while counteracting error-pro

147 me are preferentially repaired by homologous recombination repair (HR).

148 ignancy that harbors mutations in homologous recombination-repair (HR-repair) proteins in 20%-25% of

149 static prostate cancer who harbor homologous recombination repair (HRR) alterations.

150 -mediated degradation to regulate homologous recombination repair (HRR) and anti-tumor immunity.

151 dominant-negative mutant inhibits homologous recombination repair (HRR) and increases sensitivity to

152 BRCA2-RAD51 axis is essential for homologous recombination repair (HRR) and is frequently disrupted i

153 athways exist in mammalian cells: homologous recombination repair (HRR) and nonhomologous end joining

154 re repaired by BCR/ABL-stimulated homologous recombination repair (HRR) and nonhomologous end-joining

155 te, allowing for the detection of homologous recombination repair (HRR) by GFP expression.

156 stant prostate cancer (CRPC) with homologous recombination repair (HRR) defects.

157 Homologous recombination repair (HRR) enables fault-free repair of

158 atients with prostate cancer with homologous recombination repair (HRR) gene alterations, but resista

159 hibitor, suppresses expression of homologous recombination repair (HRR) genes and increases sensitivi

160 BRCA1/2 and damaging mutations in homologous recombination repair (HRR) genes.

161 ients characterized by defects in homologous recombination repair (HRR) genes.

162 cell lines are also defective in homologous recombination repair (HRR) induced by DNA double-strand

163 peculate that the contribution of homologous recombination repair (HRR) is at a stage after the initi

164 ng of DNA double-strand breaks by homologous recombination repair (HRR) is critical to the long-term

165 Homologous recombination repair (HRR) is functional during the S- a

166 Homologous recombination repair (HRR) is required for both the repa

167 A role for D1-D2-G-X3 in homologous recombination repair (HRR) is supported by our finding t

168 Homologous recombination repair (HRR) maintains chromosomal stabili

169 lvement of BRCA1 and BRCA2 in the homologous recombination repair (HRR) of double-strand breaks in DN

170 itors with drugs that inhibit the homologous recombination repair (HRR) pathway (such as PI3K inhibit

171 The homologous recombination repair (HRR) pathway repairs DNA double-st

172 ortant factor in the ATM-mediated homologous recombination repair (HRR) pathway.

173 Flp recombinase and the cellular homologous recombination repair (HRR) pathway.

174 exploiting vulnerabilities in the homologous recombination repair (HRR) pathway.

175 Homologous recombination repair (HRR) protects cells from the letha

176 dependent DNA damage response and homologous recombination repair (HRR) via decreasing DICER-generate

177 homologous end-joining (NHEJ) and homologous recombination repair (HRR), contribute to repair ionizin

178 51 homolog XRCC2 and defective in homologous recombination repair (HRR), displays significantly dimin

179 romoting RAD51 foci formation and homologous recombination repair (HRR), EGFR-mutant cells also exhib

180 e unfaithful DSB repair pathways, homologous recombination repair (HRR), nonhomologous end-joining (N

181 of BRCA1, an important factor of homologous recombination repair (HRR), preferentially sensitized st

182 SHU genes have been implicated in homologous recombination repair (HRR), their precise role(s) within

183 Hus1 decreases the efficiency of homologous recombination repair (HRR), which is associated with the

184 selective efficacy in tumors with homologous recombination repair (HRR)-defects but the activation me

185 ficant efficacy as monotherapy in homologous recombination repair (HRR)-deficient cancers.

186 pse replication forks and trigger homologous recombination repair (HRR).

187 rotein) filament is essential for homologous recombination repair (HRR).

188 ed viability and failed to induce homologous recombination repair (HRR).

189 homologous end-joining (NHEJ) and homologous recombination repair (HRR).

190 homologous end joining (NHEJ) and homologous recombination repair (HRR).

191 A damage repair genes involved in homologous recombination repair (HRR).

192 alterations in genes involved in homologous recombination repair (HRR).

193 nvolved directly or indirectly in homologous recombination repair (HRR).

194 ing genetic alterations impairing homologous recombination repair (HRR).

195 damage response genes involved in homologous recombination repair (HRR).

196 nvolved directly or indirectly in homologous recombination repair (HRR).

197 uced OFD1 impaired DSB repair via homologous recombination repair (HRR).

198 d its loss or inhibition disrupts homologous recombination repair (HRR).

199 ndent on Exo1- and Shu1-dependent homologous recombination repair (HRR).

200 ays-nonhomologous end-joining and homologous recombination repair (HRR).

201 y that is disabled as a result is homologous recombination repair (HRR).

202 gle-strand break (SSB) repair and homologous recombination repair (HRR).

203 ated spliceosome complex controls homologous recombination repair in a PAR-independent manner.

204 previously unidentified role for homologous recombination repair in correct neuronal development.

205 air of DSBs by not only promoting homologous recombination repair in G2/M phase but also facilitating

206 ether these data support a role for Mus81 in recombination repair in higher eukaryotes.

207 helicases BLM and WRN that are required for recombination repair in human cells colocalize with Mus8

208 th non-homologous end joining and homologous recombination repair in human cells, reduced micronuclei

209 with etoposide), up-regulation of homologous recombination repair in response to p53 disruption becom

210 consistent with a role for the XRCC2 gene in recombination repair in somatic cells, suggesting that i

211 Both recombination and recombination repair in T4 rely on UvsX, a RecA-like rec

212 To elucidate the role of recombination repair in the cellular response to UV, we

213 DNA double-strand breaks through homologous recombination repair, increasing the involvement of erro

214 at G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensi

215 Homologous recombination repair is likely to be intact as basal and

216 BRCA1, a key player of homologous recombination repair, is also involved in stalled DNA re

217 e structural conservation of DNA replication/recombination/repair machineries among microorganisms, t

218 f the CCTG*CAGG repeats may be mediated by a recombination-repair mechanism that is influenced by DNA

219 pport is presented for the suggestion that a recombination/repair mechanism was used by the intron fo

220 osis, with proposed roles in DNA pairing and recombination/repair mechanisms.

221 nition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss.

222 While all DSB recombination repair models include 5'-3' resection, the

223 Owing to their function in homologous recombination repair, much research has focused on the u

224 many processes in mammalian cells, including recombination, repair, mutagenesis and apoptosis.

225 these factors prevents oocyte elimination in recombination-repair mutants, even when the abundance of

226 tate cancer (mCRPC) unselected by homologous recombination repair mutation (HRRm) status, with benefi

227 BRCA2 is necessary for homologous recombination repair of DNA and the prevention of diseas

228 ce of BRCA2 substantially reduced homologous recombination repair of DNA breaks, whereas the absence

229 protein complex is essential for homologous recombination repair of DNA damage and maintaining genom

230 num agents owing to deficiency in homologous recombination repair of DNA damage.

231 has no effect on BRCA2-dependent homologous recombination repair of DNA damage.

232 nction together with Rhp51 in the homologous recombination repair of DNA double strand breaks.

233 on-induced cell death and reduced homologous recombination repair of DNA double-strand breaks and pro

234 away from the eukaryotic model of homologous recombination repair of DNA double-strand breaks.

235 he latter of which is involved in homologous recombination repair of DNA double-strand breaks.

236 The fact that this pathway mediates recombination repair of DNA DSBs suggests that DNA DSBs

237 4, plays an important role in the homologous recombination repair of double strand breaks.

238 sibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as

239 find that SETD2 is necessary for homologous recombination repair of DSBs by promoting the formation

240 and TRIP13, proteins normally essential for recombination repair of meiotic DSBs, is substantially b

241 essing of other types of DNA damage, such as recombination repair of replication forks stalled at DNA

242 toproducts, the FA/BRCA pathway mediates the recombination repair of replication forks stalled at DNA

243 interstrand cross-links, involvement in VDJ recombination, repair of DNA double-strand breaks, and p

244 ons are structures present during homologous recombination, repair of double stranded DNA breaks, and

245 nctional phospho-protein with roles in V(D)J recombination, repair of double-strand breaks by nonhomo

246 , TOP3, SRS2 and CTF4, which are involved in recombination, repair of replication forks and the estab

247 During V(D)J recombination, repair of these RAG-generated double-stra

248 SOS response and are defective in homologous recombination, repair of UV damaged DNA, double-strand b

249 terations in genes with a role in homologous recombination repair, olaparib was associated with longe

250 ty to nucleotide excision repair, homologous recombination repair, or postreplication repair when com

251 sal of damage, excision repair, conventional recombination repair, or translesion synthesis.

252 in gene regulation, chromosome organization, recombination, repair, or replication, and mutation of t

253 RCA1-mediated DDR events: (i) the homologous recombination repair pathway and (ii) the arrest of cell

254 hereby impaired the high-fidelity homologous recombination repair pathway and sensitized cells to sma

255 We therefore studied activation of the recombination repair pathway by solar available doses of

256 host polymerases, proteins of the homologous recombination repair pathway may be considered essential

257 r, especially the RAD51-dependent homologous recombination repair pathway, is executed in vivo.

258 f DNA double-strand breaks in the homologous recombination repair pathway.

259 erase RAD51 is a component of the homologous recombination repair pathway.

260 ons or those without a functional homologous recombination repair pathway.

261 itotic cells preferentially use a homologous recombination repair pathway.

262 refore directly competes with the homologous recombination repair pathway.

263 epair and the double-strand break/homologous recombination repair pathways.

264 proteins, Ercc1 and Xpf are also involved in recombination repair pathways.

265 s (TLS), Fanconi anemia (FA), and homologous recombination repair pathways.

266 RAD51 family may also function in homologous recombination-repair pathways.

267 he spindle assembly checkpoint, numerous DNA recombination/repair pathways, and the initiation of aut

268 the helicases Rqh1 and Srs2 but not on other recombination/repair pathways.

269 Recombination repair plays an important role in the proc

270 ught to affect genomic stability through DNA recombination/repair processes.

271 use of competition between DNA synthesis and recombination/repair processes?

272 to function in vivo to stimulate homologous recombination repair proficiency.

273 Recombination repair protein 1 (Rrp1) includes a C-termi

274 Drosophila Rrp1 (recombination repair protein 1) is a DNA repair enzyme w

275 ces a distinct set of foci of the homologous recombination repair protein Rad51 that are colocalized

276 a small-molecule inhibitor of DNA homologous recombination repair protein RAD51, significantly enhanc

277 d DNA binding protein RPA and the homologous recombination repair protein Rad52.

278 ructural homolog of Saccharomyces cerevisiae recombination/repair protein Rad54, was cloned and expre

279 This response specifically requires the DNA recombination repair proteins BLM and BRCA2 as well as a

280 We show, in normal human cells, that the recombination/repair proteins hRAD51 and replication pro

281 address the diverse contributions of several recombination/repair proteins to telomere maintenance in

282 omplexes formed by the human Rad51 and Rad52 recombination/repair proteins.

283 camptothecin-induced DSBs and the resulting recombination repair require replication, showing that a

284 Successful recombination/repair requires the formation of a presyna

285 nts of the nucleotide excision repair (NER), recombination repair (RR), and translesion synthesis (TL

286 PARPi-induced PARP1 retention at homologous-recombination repair sites.

287 A binding and help direct DrRecQ to specific recombination/repair sites.

288 eduction in MRN/ATM signaling and homologous recombination repair, suggesting that Thr622 phosphoryla

289 How this long-tract homologous recombination repair synthesis responds to complex secon

290 Although components of the homologous recombination repair system are also involved in NHEJ, t

291 stalled replication forks by the homologous recombination repair system in humans.

292 mologue Swi5-Sfr1 is critical for homologous recombination repair, the budding yeast counterpart Sae3

293 nents have been implicated in DNA homologous recombination repair, the exact function of hMSH2/6 in t

294 t function in a common pathway in homologous recombination repair to ensure accurate nuclear division

295 H1 acts independently of 53BP1 in homologous recombination repair to promote RAD51 loading.

296 uggesting a local or time-dependent need for recombination repair to survive high rates of SHM and es

297 estrating basic cellular processes (e.g. DNA recombination, repair, transcription, RNA processing, si

298 xygen species as well as impaired homologous recombination repair underlie this DNA damage.

299 at 4 h after IR, as a measure for homologous recombination repair, was significantly reduced in ARID1

300 onsistent with the involvement of homologous recombination repair, we observed extensive sister chrom