ライフサイエンスコーパス: recurrent

1 s of clinically suspected MK were classed as recurrent.

2 ls reflect clonal haematopoiesis and are non-recurrent.

3 clinical features of 172 adults with AML and recurrent 11q23/KMT2A rearrangements, 141 of whom had ou

4 quences using nanopore sequencing identified recurrent aberrant behavior characterized by low confide

5 trostomy placement (HR 2.012, p = 0.016) and recurrent accumulation of airway secretions (HR 2.614, p

6 n that fMRI reflects predominantly input and recurrent activity, the results can be explained by an a

7 Pouch phenotype was defined as recurrent-acute pouchitis (n = 6), chronic pouchitis and

8 However, a tool to assess control of recurrent AE is not yet available.

9 eakening group, and required correction of a recurrent AHP (P = .06).

10 In addition, we identify recurrent alterations in KEAP1/NFE2L2 and WNT pathway in

11 Recurrent amplification could be solely due to positive

12 thesis that normalization in V1 operates via recurrent amplification, i.e., amplifying weak inputs mo

13 It is unknown how normalization arises from recurrent amplification.

14 ough effective instruction and prevention of recurrent anaphylaxis.

15 ings provide evidence for a circuit of local recurrent and feedback interactions that mediate rapid b

16 fier for predictively discriminating between recurrent and rare variants in the human cancer genome.

17 ells have shown encouraging activity against recurrent and refractory diffuse large B cell lymphomas

18 2 bipolar disorder correlates strongly with recurrent and single-episode major depressive disorder.

19 ophageal reflux disease (GERD) is defined by recurrent and troublesome heartburn and regurgitation or

20 Hereditary angioedema is characterized by recurrent and unpredictable episodes of subcutaneous and

21 defined based on increased susceptibility to recurrent and/or severe infections.

22 f 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 1

23 had diabetes, 13.9% were smokers, 68.7% were recurrent, and 23.6% incarcerated.

24 We report widespread, recurrent, and functionally relevant 3'-UTR alterations

25 er, all except two show clear signs of being recurrent, and we could better define the factors affect

26 A family with recurrent anencephalic fetuses was investigated to under

27 Recurrent angioedema (AE) is an important clinical probl

28 for PFAPA distinct from Behcet's disease and recurrent aphthous stomatitis.

29 In a sub-study, children with recurrent asthma-like symptoms were randomized to either

30 ectiveness in PV isolation, and freedom from recurrent atrial arrhythmias.

31 2 reported sporadic attacks; and 1 reported recurrent attacks (>4 attacks/year).

32 st, other changes, such as an increase in PC recurrent axonal collateral formation and hypertrophy of

33 MDS patients have recurrent bacterial infections and abnormal expression o

34 ions in C3 gene: c.1811delT (Val604Glyfs*2), recurrent bacterial infections, crescentic glomeruloneph

35 gests the need for new treatments to prevent recurrent bacterial vaginosis.

36 Thus, persistent gut antigens select recurrent BCR clonotypes to seed chronic PP GC responses

37 Columbia population-based registry uncovered recurrent biallelic TMEM30A loss-of-function mutations,

38 y regions that are significantly affected by recurrent breakpoints and recurrent somatic juxtapositio

39 In contrast, p190A forms harboring recurrent cancer mutations exhibit loss of function in m

40 e treatment as a strategy to reduce risk for recurrent cardiovascular events in patients who have had

41 syndrome and have also been shown to reduce recurrent cardiovascular events in patients with stable

42 i-inflammatory effects and a reduced risk of recurrent cardiovascular events in stable patients with

43 OSA is associated with an increased risk of recurrent cardiovascular events.

44 21 consecutive and 6 recurrent cases of stretched scar -induced strabismus we

45 Approximately 3.4% of new and 18% of recurrent cases of TB are multidrug-resistant (MDR) or r

46 t depressive symptoms (total of incident and recurrent cases) and the mean difference in mood scores

47 ospitalization and/or further treatments for recurrent CDI.

48 n and men were followed up for recurrent MI, recurrent CHD events (ie, recurrent MI or coronary revas

49 dy assessed sex differences in recurrent MI, recurrent CHD events, and mortality among patients with

50 ctious processes, and detect residual and/or recurrent cholesteatoma.

51 = 15; 73% metastasized) was characterized by recurrent chromosomal gains, CN-LOH, DAXX mutations, and

52 Intractable or recurrent chronic itch greatly reduces the patients' QOL

53 d circuit mechanisms, embedded in a dynamic, recurrent circuit architecture.

54 apping of synaptic connections reveals three recurrent circuit modules engaged sequentially to increa

55 Recurrent Clostridioides difficile infections (rCDI) are

56 confer maribavir resistance in patients with recurrent CMV infection while on therapy, or no response

57 e these inputs are not as strong as piriform recurrent collaterals, they are less constrained by disy

58 The risk of recurrent colonic adenoma associated with high-grade dys

59 These results suggest that recurrent connectivity, a hallmark of biological visual

60 Here we show: (1) Recurrent convolutional neural network models outperform

61 Carriers of large recurrent copy number variants (CNVs) have a higher risk

62 anked by segmental duplications overlap with recurrent copy number variants associated with neurocogn

63 Rates for recurrent coronary heart disease (CHD) events have decli

64 and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops.

65 arity is obtained in the limit of very large recurrent coupling strength.

66 the proportion of patients (20% vs 25%) with recurrent cystitis or pyelonephritis with the same ESBL-

67 ed, sham-controlled trial, 105 patients with recurrent depression who exhibited no responses to at le

68 onotherapy is effective for the treatment of recurrent depression, and the MRI-guided method of coil

69 nificant adverse events, and 4 patients with recurrent disease (n = 4) had a median overall survival

70 ts: Of 41 eligible patients, 24 patients had recurrent disease at a median of 6.5 mo after nCRT and 1

71 showed some improvement in the detection of recurrent disease at low serum prostate specific antigen

72 sue sarcoma, yet patients with metastatic or recurrent disease continue to do poorly, indicating a ne

73 or breast cancer, 25% of patients experience recurrent disease.

74 in vaccine design to reduce reactivation and recurrent disease.

75 e from which reactivation may occur to cause recurrent diseases, such as blinding herpetic stromal ke

76 and one patient underwent repeat surgery for recurrent disk herniation.

77 atment to maintain visual acuity in residual/recurrent DME after FAc.

78 n accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid d

79 The recurrent dominant BAG3-P209L mutation results in a seve

80 s been shown to accurately distinguish acute recurrent DVT from chronic thrombotic remains.

81 The baseline prevalence of recurrent DVT was 38%; superficial thrombophlebitis was

82 Recurrent endophthalmitis is rare and seen most commonly

83 p of neurological disorders characterised by recurrent epileptic seizures.

84 r 82 of 123 patients (67%), it was the first recurrent episode, 31 patients had 2-5 previous episodes

85 n 2006 and 2018, 143 (6%) were identified as recurrent episodes in 123 patients.

86 equently progresses to chronicity, marked by recurrent episodes interspersed with asymptomatic period

87 major burden of rehospitalization caused by recurrent episodes of infection.

88 haemodynamic responses to different types of recurrent episodes of intermittent hypoxia and/or bradyc

89 anical ventilation in 3 patients, as well as recurrent episodes of rhabdomyolysis triggered by infect

90 Of the recurrent episodes, 27 had known CSF leakage (71%) of wh

91 can occur in early childhood and following a recurrent episodes, it progresses to scarring and visual

92 for treatment interactions; the analysis of recurrent events was based on rate ratios derived from t

93 present molecular and functional evidence of recurrent evolution of chlorosis, describe a biliverdin-

94 ema, and chronic bronchitis, or to alleviate recurrent exacerbations.

95 ral circuit model of layer 2/3 revealed that recurrent excitation enhances sensory signals by amplifi

96 imulus and surround, primarily by modulating recurrent excitation.

97 he paradoxical effect implies not too strong recurrent excitation.

98 urons had greater intrinsic excitability and recurrent excitatory synaptic strength, while E/I ratio,

99 , waitlist mortality, and transplant rate by recurrent falls (>=2 falls) before evaluation using adju

100 Candidates with recurrent falls (6.5%) had a lower chance of listing (ad

101 the 14th and 15th centuries associated with recurrent famines, the Black Death pandemic, and politic

102 The recurrent feedback loop effectively carried frequencies

103 ly 40's-year-old man had been suffering from recurrent fever attack once in 1-2 months during childho

104 , muscular hypotonia, feeding abnormalities, recurrent fever episodes, and infantile spasms .

105 nosis when we meet with the adult patient of recurrent fever.

106 Importantly, chromothripsis generated recurrent fusions that drove tumor development.

107 However, second surgeries for recurrent GBM are not routinely performed, and therefore

108 umor progression in patients with primary or recurrent GBM.

109 Recurrent gene modules and cell types are affected acros

110 hology practice has led to identification of recurrent gene rearrangements and fusions in a variety o

111 mutant histone variant, H3.3-G34W, as a sole recurrent genetic alteration.

112 right." Hyperactivated Wnt signaling due to recurrent genetic alterations drives several human cance

113 matic analysis provides new insight into the recurrent genomic alterations associated with telomere m

114 With the advent of genomic technologies, recurrent genomic amplification has been mapped througho

115 ress enhances appearance of dozens of robust recurrent genomic break clusters, termed RDCs, in cultur

116 Patients with recurrent HCC after LT from 2002 to 2016 were reviewed f

117 Interviews and assessments of recurrent HCV viremia occurred at 6-month intervals for

118 apy is modest in patients with metastatic or recurrent head and neck squamous cell carcinoma (HNSCC).

119 A recurrent hernia (any size) was identified in 39.3% afte

120 e predictors of wound complications, whereas recurrent hernia repair (2.69, 1.14-6.35), biologic mesh

121 o, despite being infected, never develop any recurrent herpetic disease).

122 dersen-Gill modeling to analyze total (first+recurrent) HHF and total HHF/CV death events.

123 sterior fossa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and ex

124 y did not support HPV vaccination to prevent recurrent HSIL after LEEP in women living with HIV.

125 Background In cystic fibrosis (CF), recurrent imaging and pulmonary function tests (PFTs) ar

126 Cutaneous inflammation is recurrent in systemic lupus erythematosus (SLE), yet mec

127 a virulent Escherichia coli strain, whereas recurrent infections and asymptomatic bacteriuria common

128 Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-threatenin

129 S gene, leading to thrombocytopenia, eczema, recurrent infections, autoimmune disease, and malignancy

130 ion, specific hair shaft defects, atopy, and recurrent infections.

131 able treatment strategy for children without recurrent infections.

132 Renshaw cells mediate recurrent inhibition between motoneurons within the spin

133 Recurrent inhibition was strongest to motoneurons innerv

134 assigned patients 2:1 with untreated locally recurrent inoperable or metastatic triple-negative breas

135 These results demonstrate how recurrent interactions in a simple and modular neural ci

136 e acute lymphoblastic leukemias identified a recurrent intronic variant predicted to cis-activate the

137 ing patients with clinically suspected acute recurrent ipsilateral DVT.

138 hetized female macaque monkeys, and recorded recurrent IPSPs in response to antidromic stimulation of

139 The coprimary outcomes were recurrent ischaemic event (stroke/TIA/systemic arterial

140 patients qualified; 104 patients (6.8%) had recurrent ischaemic events and 23 patients (1.5%) had d-

141 models, factors associated with a trend for recurrent ischaemic events were prior stroke or transien

142 ictors of d-sICH are different than those of recurrent ischaemic events; therefore, recognising these

143 posite of death, myocardial infarction (MI), recurrent ischemia, or thrombotic bailout at 96 h (4-way

144 .50-4.43), nor did they have a lower rate of recurrent ischemic events (vs >14 days; OR = 0.76, 95% C

145 c compression of the posterior branch of the recurrent laryngeal nerve following the progressive open

146 h eyes following 3 months of PTX therapy for recurrent liver metastases.

147 pe-specific and thalamic subnucleus-specific recurrent loops, with both CT and PT neurons providing t

148 for CAD is associated with elevated risk for recurrent MACE after acute coronary syndrome and a large

149 ly associated with the risk of mortality and recurrent MACEs.

150 ovascular Risk Reduction Study [Reduction in Recurrent Major CV Disease Events] (CANTOS); NCT01327846

151 h those from meta-GWASs of self-reported and recurrent major depressive disorder (MDD), bipolar disor

152 ay for the acute treatment and prevention of recurrent mania/hypomania and depression that characteri

153 n two MAS mouse models and in a patient with recurrent MAS.Conclusions: Our data indicate that IL-18

154 We identified novel recurrent MCL drivers, including CDKN1B, SAMHD1, BCOR, S

155 of broad depression with self-reported MDD, recurrent MDD, bipolar disorder and schizophrenia.

156 Nearly all recurrent medulloblastomas and posterior fossa group A (

157 20-week regimen developed culture-confirmed recurrent melioidosis (HR 2.66; 95% confidence interval

158 condary composite endpoint combining overall recurrent melioidosis and mortality was assessed post-ho

159 enomic and molecular targets for a subset of recurrent/metastatic SDC.

160 e blood count in 28 patients was lower after recurrent MI compared with their first MI.

161 for recurrent MI, recurrent CHD events (ie, recurrent MI or coronary revascularization), heart failu

162 Recurrent MI was induced by ligating the left circumflex

163 Women and men were followed up for recurrent MI, recurrent CHD events (ie, recurrent MI or

164 This study assessed sex differences in recurrent MI, recurrent CHD events, and mortality among

165 this unmet need through establishing a deep recurrent model to predict and eliminate the PHT compone

166 ifocally as multilobulated or ovoid lesions, recurrent MPNSTs purely occur multifocally as mostly nod

167 Primary and recurrent MPNSTs were examined for configuration, contra

168 Chronic recurrent multifocal osteomyelitis (CRMO) in humans can

169 pediatric autoinflammatory disease, chronic recurrent multifocal osteomyelitis (CRMO).

170 Functional analysis of recurrent mutants E98K and D140A revealed enhanced bindi

171 We find that each ASD gene with recurrent mutations can be characterized by a parameter,

172 We apply this index to a curated set of recurrent mutations identified within a dataset of 46,72

173 ealed that the identified genes overlap with recurrent mutations in human cancers.

174 transmissible lineages of SARS-CoV-2 due to recurrent mutations.

175 Using a recurrent network model, we explore whether this could b

176 The prefrontal cortex and striatum form a recurrent network whose spiking activity encodes multipl

177 modifications of synaptic weights within its recurrent network.

178 p-learning model: the long-short-term memory recurrent neural network (LSTM-RNN).

179 or the convolutional neural network with the recurrent neural network based deep learning structure t

180 ine learning algorithms, Random Forest and a Recurrent Neural Network model, for gaze event classific

181 advances in machine translation, we train a recurrent neural network to encode each sentence-length

182 so-called CLPred, which uses a bidirectional recurrent neural network with long short-term memory (BL

183 references are learned using a bidirectional recurrent neural network.

184 ing scholars, by modeling the language using recurrent neural networks and automatically completing t

185 We address an investigation with Recurrent Neural Networks in the task of forecasting bee

186 ctions, most studies integrate bidirectional recurrent neural networks into their models.

187 datasets, laboratory measurements, and deep recurrent neural networks.

188 We used a recurrent-neural-network architecture to predict the inc

189 low IQ and after removing de novo and known recurrent neuropsychiatric CNVs.

190 We identify 127,727 recurrent non-reference unique insertions spanning 18,04

191 ctomy was done for three eyes (17.6%) due to recurrent non-resolving VH in group I. late recurrent VH

192 We describe a functional role for these recurrent noncoding mutations in disrupting an autoregul

193 Our sequencing revealed novel recurrent noncoding mutations surrounding a single exon

194 way for T-cell-based immunotherapy to combat recurrent ocular herpes.

195 ay to targeting immune checkpoints to combat recurrent ocular herpes.

196 disease in immunocompromised individuals and recurrent ocular lesions in the immunocompetent.

197 vaccine plus pembrolizumab for patients with recurrent or advanced cervical cancer was safe and treat

198 rolizumab showed antitumour activity against recurrent or advanced cervical cancer.

199 Recurrent or refractory disease can be effectively treat

200 pment or function can present with atypical, recurrent, or severe herpesviral infections.

201 Recent recurrent outbreaks of Gram-negative bacteria show the c

202 State-of-the art therapy for recurrent ovarian cancer suitable for platinum-based re-

203 event in a group of ~30 cancer cells from a recurrent ovarian carcinoma.

204 reditary angioedema (HAE) is associated with recurrent, painful, and potentially lifethreatening atta

205 ca landrace, and NSIC Rc222, a high-yielding recurrent parent.

206 udy included 102 patients with biochemically recurrent PC after radical prostatectomy undergoing (18)

207 Then, lesions suspected of being recurrent PC were differentiated from lesions attributed

208 68)Ga-PSMA11 PET/CT because of biochemically recurrent PC.

209 Six patients with recurrent PDGFRalpha-driven glioma were treated with das

210 ilonacept in patients with acute symptoms of recurrent pericarditis (as assessed on a patient-reporte

211 arize the up-to-date management of acute and recurrent pericarditis.

212 eukin-1 has been implicated as a mediator of recurrent pericarditis.

213 y to be made misunderstanding for infectious recurrent pharyngitis, it is important to note that we s

214 middle or deeper V1 layers, consistent with recurrent plasticity mechanisms via horizontal connectio

215 nt failure was independently associated with recurrent pneumonia or death among patients with bacteri

216 ctions may be an independent risk factor for recurrent postinjection endophthalmitis.

217 esearch must investigate the pathogenesis of recurrent pregnancy loss and evaluate novel diagnostic t

218 though progress in predicting and preventing recurrent pregnancy loss has been hampered by a lack of

219 Recurrent pregnancy loss is a distressing pregnancy diso

220 The prognosis for couples with recurrent pregnancy loss is generally good, although the

221 We also show that a subset of unexplained recurrent pregnancy losses (idiopathic RPLs) is associat

222 This suggests the necessity of recurrent processing in these computations.

223 ith prior work, these results implicate fast recurrent processing through vlPFC as critical to produc

224 ult in modulating representations in EVC via recurrent processing.SIGNIFICANCE STATEMENT How we perce

225 Biochemically recurrent prostate cancer (BCR) is the main indication t

226 is an attractive treatment for biochemically recurrent prostate cancer (PCa), whereby cycling treatme

227 offers high detection rates in biochemically recurrent prostate cancer patients and is positive in ab

228 SMA-11 PET/MRI has a high detection rate for recurrent prostate cancer, even at low PSA levels no hig

229 ultiparametric MRI in men with biochemically recurrent prostate cancer.

230 ymmetric Hebbian rules in sparsely connected recurrent rate networks and develop a theory of the tran

231 e inhibited, HSV-1 can reactivate, and these recurrent reactivation events can lead to blinding scarr

232 ant mucositis with a reduced support, and 3) recurrent/refractory peri-implantitis.

233 own promising results in a phase II study in recurrent/refractory pericarditis.

234 e as second-line treatment for patients with recurrent/refractory pericarditis.

235 Recurrent reports of suboptimal influenza vaccine effect

236 hy children and 40 children with unexplained recurrent respiratory infections, revealing age-dependen

237 es examined all coronary revascularizations, recurrent revascularizations, and revascularization subt

238 reoretinopathy in turn increases the risk of recurrent RRD and may lead to blindness.

239 with MDROs, and 13 cases (16.9%) of de novo/recurrent SBP.

240 duced muscle tone, and one of them developed recurrent seizure.On physical examination, the child sho

241 elevant autoantibody target in patients with recurrent seizures and suspected encephalitis as leading

242 PDE is characterized by recurrent seizures that are resistant to conventional an

243 Recurrent sex chromosome drive can have profound ecologi

244 Recurrent skin infections were common, particularly in c

245 e (OSAS) represents a substantial disease of recurrent sleep fragmentation, leading to intermittent h

246 roved diagnostic performance in detection of recurrent soft-tissue sarcoma.

247 s within these three groups contained either recurrent soft-tissue sarcomas or positive postoperative

248 We identify significantly recurrent somatic alterations in these gliomas including

249 cantly affected by recurrent breakpoints and recurrent somatic juxtapositions.

250 deadly pediatric solid tumor with infrequent recurrent somatic mutations.

251 These variants include a recurrent splicing variant that was initially overlooked

252 es, which can then be quarantined to prevent recurrent spread of the disease worldwide.

253 us epilepticus, and a wean failure as either recurrent status epilepticus or the resumption of anaest

254 f intravenous anaesthesia without developing recurrent status epilepticus, and a wean failure as eith

255 driven by specific clinical characteristics (recurrent status, remission status, antidepressant medic

256 alcium oxalate stones (OS) and patients with recurrent stones (RS).

257 assess the short-term and long-term risk of recurrent stroke and mortality after a first stroke for

258 ge (ICH) are at increased long-term risks of recurrent stroke and other comorbidities.

259 as associated with an increased incidence of recurrent stroke or TIA: 2.32 versus 0.75 events per 100

260 nosis was perceived to convey a high risk of recurrent stroke, but two previous trials (SAMMPRIS and

261 H, the substantially higher 10-year risks of recurrent stroke, dementia and lower QALYs after lobar I

262 years, we determined the long-term risks of recurrent stroke, disability, quality of life, dementia

263 After a first ischaemic stroke, 91% of recurrent strokes were also ischaemic stroke; after an i

264 ; after an intracerebral haemorrhage, 56% of recurrent strokes were intracerebral haemorrhage, and 41

265 s were intracerebral haemorrhage, and 41% of recurrent strokes were ischaemic stroke.

266 tool that analyzes SV candidates to identify recurrent SVs and their targeted sites (hotspot regions)

267 Experts agreed on initiating ATT in recurrent TAU, TIU, TPU, and active TRV depending on the

268 ealed potential immune evasion mechanisms in recurrent tumor cells that dampen DC antigen presentatio

269 A second group of recurrent tumors comprises thousands of subclones, has a

270 Remarkably, CD8(+) T cells in recurrent tumors overexpressed KLRB1 (CD161) and display

271 Recurrent tumors were generally less proliferative than

272 w-grade, 34 high-grade; 9 primary tumors, 34 recurrent tumors) who had preoperative (time before surg

273 st diverse forms of anticancer therapy, seed recurrent tumours, and disseminate to and colonize dista

274 suspected in a young patient presenting with recurrent unihemispheric strokes particularly when conve

275 is a common neurological disorder defined by recurrent, unprovoked seizures.

276 trogen, associates with an increased risk of recurrent urinary tract infections (rUTIs) linked to uro

277 All mutations, including the recurrent variant p.Arg1295* observed in 8/21 probands,

278 patients who become resistant to LEN harbour recurrent variants of TP53 or RUNX1.

279 The primary efficacy outcome, symptomatic recurrent venous thromboembolism (assessed by intention-

280 recurrent non-resolving VH in group I. late recurrent VH occurred in two eyes (11.8%) in group II, I

281 Recurrent visual axis opacification (VAO) occurred in 7.

282 oided during AM, but is often of benefit for recurrent VT after the acute phase of myocarditis.

283 The risk of the composite of recurrent VTE or major bleeding was nonsignificantly low

284 alysis comprising 2607 patients, the risk of recurrent VTE was nonsignificantly lower with DOACs than

285 eatment duration in patients at high risk of recurrent VTE.

286 Recurrent wheeze and asthma in childhood are commons cau

287 n to intensive care unit) and development of recurrent wheeze by age 3 years.

288 primary outcome was offspring with asthma or recurrent wheeze by age 3 years.

289 th and without asthma on childhood asthma or recurrent wheeze development.

290 ed by maternal asthma on childhood asthma or recurrent wheeze development.

291 the effect of serum sRAGE on development of recurrent wheeze is mediated through acute severity.

292 protective trend was reiterated in asthma or recurrent wheeze progression to active asthma from age 3

293 18 years) with physician-diagnosed asthma or recurrent wheeze were recruited, including 208 (44%) pre

294 evere asthma, and in preschool children with recurrent wheeze.

295 th respect to time to the onset of asthma or recurrent wheeze.

296 f life was associated with increased risk of recurrent wheezing by age 3 years and asthma that persis

297 hiolitis hospitalization was associated with recurrent wheezing by age 3 years, possibly providing ne

298 talization and 3 later points to the risk of recurrent wheezing by age 3 years.

299 re was 88% follow-up at 3 years, and 31% had recurrent wheezing.

300 We projected that recurrent wintertime outbreaks of SARS-CoV-2 will probab