ライフサイエンスコーパス: reductase

1 nal reductase PTGR1 and methionine sulfoxide reductase.

2 -binding protein, and a methionine sulfoxide reductase.

3 highly regio- and enantioselective carbonyl reductase.

4 resembles the structure of class II chromate reductase.

5 coding a highly efficient gonococcal nitrite reductase.

6 al of identifying the respiratory antimonate reductase.

7 GSSG accumulation in an organism lacking GSH reductase.

8 sents a new subclass of cytochrome c nitrite reductase.

9 ia a putative novel type of heme copper O(2) reductase.

10 either protein resulted in decreased sulfite reductase.

11 des an NADPH-dependent flavin mononucleotide reductase.

12 ply of NADPH, the preferred cofactor of GalA reductases.

13 1-regulated genes are putative methylglyoxal reductases.

14 LmbY and GriH unusual, if not unique, among reductases.

15 related to beta-lactamases and nitric oxide reductases.

16 chromes, many of which function as anaerobic reductases.

17 olefins catalyzed by flavin-dependent 'ene'-reductases.

18 e (HCT) or loss of function of cinnamoyl CoA reductase 1 (CCR1) express a suite of pathogenesis-relat

19 Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reac

20 a and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis.

21 and interaction with pyrroline-5-carboxylate reductase 1 (PYCR1), resulting in inhibition of proline

22 directly regulates the expression of nitrite reductase 1.1 (ZmNIR1.1) by binding to the nitrate-respo

23 Thioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and

24 or A (TFAM) and p53-inducible ribonucleotide reductase 2 (p53R2), which are involved in mtDNA transcr

25 owing novel information acquisition, quinone reductase 2 (QR2) is suppressed by miRNA-182 (miR-182) i

26 Human steroid 5alpha-reductase 2 (SRD5A2) is an integral membrane enzyme in s

27 ime a dopamine D1 receptor-dependent quinone reductase 2 pathway in interneurons.

28 Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thiore

29 ydrotestosterone (DHT) via the enzyme 5alpha-reductase (5alpha-R) or to the active estrogen 17beta-es

30 educed preoperative expression of biliverdin reductase A (BVRA), the enzyme that converts biliverdin

31 f glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest r

32 estigated whether uric acid regulates aldose reductase, a key enzyme in the polyol pathway.

33 nzymes, acyl-acyl carrier protein (acyl-ACP) reductase (AAR) and aldehyde-deformylating oxygenase (AD

34 mes homologous to MCR named alkyl-coenzyme M reductase (ACR).

35 citation of flavin hydroquinone within "ene"-reductase active sites enables new substrates to partici

36 ificantly increases copper-catalyzed nitrite reductase activity (CuNiR).

37 ude those with carbonic anhydrase or nitrite reductase activity by incorporating a ZnHis(3) or CuHis(

38 Attenuation reductase activity in C163S can be partially restored to

39 R14 and LBR uniquely share the same Delta-14 reductase activity in cholesterol biosynthesis, yet litt

40 (1, dppa=mu(2) -(Ph(2) P)(2) NH) has N(2) O reductase activity in methanol solvent, mediating 2 H(+)

41 ory mechanism in which the protein disulfide reductase activity of thioredoxins (TRXs) plays a centra

42 BPSS2242 exhibited NADPH-dependent reductase activity toward diacetyl and methylglyoxal, to

43 upredoxin models, and enhancement of nitrite reductase activity up to 1000-fold.

44 ibits reduced NADH-dependent hydroxypyruvate reductase activity while showing improved NADPH-dependen

45 We also report that CblC exhibits nitrite reductase activity, converting cob(I)alamin and nitrite

46 domain and does not exhibit cellular ferric reductase activity.

47 covery of proteins associated with oxidative reductase activity.

48 ha-ESA or PunA precursors through a Delta-13 reductase activity.

49 rsenate than phosphate; PvGSTF1 has arsenate reductase activity; and PvOCT4 localizes as puncta in th

50 of the Cu(Z) catalytic site of nitrous oxide reductase: activity in the 4Cu(I) :1S redox state, use o

51 We identify the aldo-keto reductase AKR1B10 as a metastasis enhancer that has litt

52 Two c-type cytochrome reductases also possess atypical heme-binding sites, the

53 d the electron acceptor methionine sulfoxide reductase, also from E. coli, strongly hinted that thior

54 Thus, CcoG is a bacterial cupric reductase and a founding member of a widespread class of

55 re cycled rapidly between ferredoxin-NADP(+) reductase and a second enzyme-the pairs being juxtaposed

56 bonyl detoxifying enzymes, such as aldo-keto reductase and carbonyl reductase, were detected after H(

57 The newly described nitrite reductase and denitration activities of CblC extend its

58 ing strains that are able to express nitrite reductase and grow in anaerobic environments, such as th

59 i_3974 and Cbei_3904, which encode aldo-keto reductase and previously annotated short chain dehydroge

60 Both 3-Hydroxy-3-Methylglutaryl-CoA Reductase and Proprotein Convertase Subtilisin/Kexin typ

61 as genetically proxied inhibition of HMG-CoA reductase and secondary exposures were genetically proxi

62 ting enzymes: 3-hydroxy-3-methylglutaryl CoA reductase and squalene monooxygenase.

63 he Grx reaction was reduced by NADPH and GSH reductase and this enzyme was essential because reaction

64 from the folate cycle (mainly dihydrofolate reductase and thymidylate synthase, respectively).

65 to the function of integral membrane steroid reductases and may facilitate drug development.

66 from known nitrogenases and nitrogenase-like reductases and specifically functions in C-S bond breaka

67 e report the discovery of over 300 new imine reductases and the production of a large (384 enzymes) a

68 necessary for a functional methyl-coenzyme M reductase, and all subunits were detected in protein ext

69 In anthocyanidin reductase (ANR) assays, an (-)-epicatechin conjugate was

70 Inhibition of aldose reductase (AR), the first enzyme of the polyol pathway,

71 enous), its metabolite uric acid, and aldose reductase (AR, the only endogenous enzyme that produces

72 oxidase AioA and the dissimilatory arsenate reductase ArrA in the Eastern Tropical North Pacific (ET

73 catalytic subunits of a respiratory arsenate reductase (arrA), periplasmic nitrate reductase (napA) a

74 The enzyme uses NADPH-cytochrome P450 reductase as a donor of electrons and hydroxylates cinna

75 enzymes) and sequence-diverse panel of imine reductases available for screening.

76 composed of NADH (or NADPH), cytochrome b(5) reductase (b(5)R), and cytochrome b(5) (cyt b(5)).

77 cytosolic pool of human methionine sulfoxide reductase B2 (MsrB2) is strongly recruited at the midbod

78 ng systems, cytochrome b5 (B5)/cytochrome b5 reductase (B5R) and cytochrome P450 reductase (CPR) were

79 pound for the B. bacteriovorus dihydrofolate reductase (Bd DHFR).

80 Through this approach we identified imine reductase biocatalysts capable of accepting structurally

81 oding a beta-keto acyl carrier protein (ACP) reductase (BKR) putatively associated with polyketide fa

82 restingly, the AHA2 proton pump and the FRO2 reductase, both of which work in concert with IRT1 in th

83 -32 requires functional arsenate respiratory reductase but does not depend on its metal-reducing-like

84 Biliverdin reductase (BVR)-A is a pleotropic enzyme converting bili

85 ed an unexpected inhibition of glutamyl-tRNA reductase by immature tRNA(Glu) We further demonstrate t

86 a sinensis ANRa (CsANRa), leucoanthocyanidin reductase c (CsLARc), and CsMYB5b (a transcription facto

87 Flavin-dependent "ene"-reductases can generate stabilized alkyl radicals when i

88 by mitochondrial adrenodoxin and adrenodoxin reductase, can efficiently catalyze the conversion of MP

89 (AO) or (ii) carboxylic acid/carboxylic acid reductase (CAR) to affect N-alkylation reactions.

90 on of AA to 6-ACA and HMD by carboxylic acid reductases (CARs) and transaminases (TAs), which involve

91 ic arsenite oxidase and respiratory arsenate reductase catalytic subunits represent a more ancient li

92 nt subgroup is the cytochrome c dependent NO reductases (cNOR), which reduce nitric oxide to nitrous

93 Individual redox states of the reductase CntB and the catalytic component CntA were inv

94 Acinetobacter baumannii (Ab) oxygenase CntA/reductase CntB is implicated in the onset of human cardi

95 gly hinted that thioredoxins and thioredoxin reductases co-evolved and that the promiscuity of thiore

96 its its effect to the motor via the fumarate reductase complex (FrdABCD), shown to bind to FliG-one o

97 agenomes for homologues of methyl-coenzyme M reductase complex (MCR), we have obtained ten metagenome

98 nsignaling receptor called vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2), calnex

99 APDs, catalyzed by F(420)H(2)-dependent Apd6 reductases, contributes to the structural diversity of A

100 in the mitochondrial ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) gene, which co-segrega

101 catalytic domain and a NADPH-cytochrome P450 reductase (CPR) domain containing FAD and FMN cofactors

102 hrome b5 reductase (B5R) and cytochrome P450 reductase (CPR) were measured in aortic SMCs.

103 een the copper centers in the copper nitrite reductase (CuNiR) family of enzymes.

104 trite reductase (CXXCK) and the SirA sulfite reductase (CX(12)NKGCH).

105 typical heme-binding sites, the NrfA nitrite reductase (CXXCK) and the SirA sulfite reductase (CX(12)

106 obin (MetHb) concentrations, cytochrome b(5) reductase (CYB5R) enzyme activities, genotypes, and clin

107 and highlight mitochondrial 2,4-dienoyl-CoA reductase (DECR1), an auxiliary enzyme of beta-oxidation

108 n the SRD5A2 gene have been linked to 5alpha-reductase deficiency and prostate cancer.

109 ein (GFP) under the control of dihydrofolate reductase degradation domain (DDD) with a hemagglutinin

110 ubiquitin ligase Hrd1 (hydroxymethylglutaryl reductase degradation protein 1), and is necessary for t

111 atalytic subunit of a respiratory antimonate reductase, designated anrA.

112 nces in the reaction specificity of the Apd6 reductases determine the formation of the fully saturate

113 rol reductase (DHCR7), 14-dehydrocholesterol reductase (DHCR14), and lamin-B receptor (LBR), share ev

114 s to be the constitutively active C14-sterol reductase, DHCR14 levels are tunable, responding to the

115 e controls activity of 24-dehydrocholesterol reductase (DHCR24), the enzyme that catalyzes conversion

116 on, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression.

117 cholesterol production, 7-dehydrocholesterol reductase (DHCR7), 14-dehydrocholesterol reductase (DHCR

118 SD risk can be affected by the dihydrofolate reductase (DHFR) genotype and cord plasma creatinine.

119 Our work resolves distinct dihydrofolate reductase (DHFR) ligand-protein conformations, allows in

120 ted region of Escherichia coli dihydrofolate reductase (DHFR), using only unsigned chemical shift cha

121 orted to competitively inhibit dihydrofolate reductase (DHFR).

122 dscape of the metabolic enzyme dihydrofolate reductase (DHFR).

123 r of eNOS) biosynthesis enzyme dihydrofolate reductase (DHFR, salvage pathway) mRNA levels showed a s

124 Enzymes of the dimethyl sulfoxide reductase (DMSOR) family catalyse two-electron redox rea

125 ear molybdoenzymes of the dimethyl sulfoxide reductase (DMSOR) family catalyze a number of reactions

126 d a large deletion of the non-catalytic P450 reductase domain, which chemoselectively C(3)-alkylates

127 nnecting the catalytic heme and the diflavin reductase domains, further highlighted the importance of

128 lts from higher expression of ribonucleotide reductase driven by increased CcrM.

129 e-cysteine peroxiredoxin alkyl hydroperoxide reductase E from Mycobacterium tuberculosis (MtAhpE-SH)

130 cterium tuberculosis is catalysed by mycolyl reductase encoded by the Rv2509 gene.

131 A single enzyme (benzyl ether reductase, encoded by the gene ber) was sufficient for t

132 The enoyl-acyl carrier protein reductase enzyme FabI is essential for fatty acid biosyn

133 in a manner reversed by methionine sulfoxide reductase enzymes.

134 The BiP co-chaperone and reductase ERdj5 (DNAJC10) is part of the endoplasmic ret

135 Flavin-dependent 'ene'-reductases (EREDs) are exquisite catalysts for effecting

136 Flavin-dependent 'ene'-reductases (EREDs) are highly selective catalysts for th

137 Moreover, the Apd6 reductases establish the first F(420)H(2)-dependent enzy

138 Uric acid dose-dependently stimulated aldose reductase expression in the HepG2 cells, and this stimul

139 cemic rats exhibited elevated hepatic aldose reductase expression, endogenous fructose accumulation,

140 Klotho deficiency suppressed GR (glutathione reductase) expression and activity in the heart via inhi

141 inhibition of the enoyl-acyl carrier protein reductase FabI, as validated by in vitro enzyme assays a

142 Enoyl-acyl carrier protein reductase (FabI) catalyzes a rate-controlling step in ba

143 f the glutaredoxin GRXS17, a member of thiol reductase families in the model plant Arabidopsis (Arabi

144 e belonging to the short-chain dehydrogenase/reductase family.

145 ent action of two ferredoxin-dependent bilin reductases (FDBRs).

146 ndrial ferredoxin FDX2 and its NADPH-coupled reductase FDXR.

147 ated transfer of multiple electrons from the reductase, Fe-protein, to the catalytic component, MoFe-

148 n of NO to N(2)O by flavodiiron nitric oxide reductases (FNORs) is related to the disruption of the d

149 nt and can be mediated by ferredoxin-NADP(+) reductase (FNR) in vitro.

150 olybdenum (Mo), which is required by nitrate reductase for denitrification and dissimilatory nitrate

151 We examined YpdA, a putative bacillithiol reductase, for its role in maintaining intracellular red

152 ural characterization of Bsp5, an imino acid reductase from the d-2-hydroxyacid dehydrogenase family

153 ith the participation of a FDX-dependent TRX reductase (FTR).

154 ptide synthetase (NRPS)-like carboxylic acid reductase (Fub8) in making an aliphatic alpha,beta-unsat

155 uction from medications that inhibit HMG-CoA reductase; further research is needed to understand whet

156 By one reductive step catalyzed by GalA reductases, GalA is converted to the polyhydroxy acid L-

157 romatin deformation, and DHFR (dihydrofolate reductase) gene transcription.

158 Homologues of 5alpha-reductase genes have been identified in molluscs.

159 al APCs, gamma-IFN-inducible lysosomal thiol reductase (GILT) is critical for MHC class II-restricted

160 eukaryotes and many bacteria, glutamyl-tRNA reductase (GluTR) is the most tightly controlled enzyme

161 it serves as the substrate of glutamyl-tRNA reductase (GluTR), the enzyme catalyzing the committed s

162 Guanosine 5'-monophosphate reductase (GMPR) is involved in the purine salvage pathw

163 , superoxide dismutase (SOD) and glutathione reductase (GR) activities, which led to a marked reducti

164 and high sequence similarity to glutathione reductase (GR) was implicated in this process.

165 In line with this, inhibition of GSH reductase (GR), the enzyme responsible for GSH recycling

166 t by the denitrosylase, S-nitrosoglutathione reductase (GSNOR).

167 tically, AMPKalpha1 regulate the glutathione reductase (GSR) phosphorylation possibly through residue

168 hioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and Nrf2 transcription factor-driven a

169 posed metalloreductases, but specific cupric reductases have not been identified in bacteria.

170 produced by hydroxymethylbutenyl diphosphate reductase (HDR/IspH), the final step of the plastidic is

171 Ubiquinol-cytochrome c reductase hinge protein (UQCRH) is the hinge protein for

172 abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-

173 eakens the ability of ectopic HMG Coenzyme A reductase (Hmgcr) to induce germ cell migration defects.

174 1 (Srebp1c), 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), and cytochrome P450 family 7 subfamil

175 degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the meval

176 ion of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR).

177 HMG-CoA reductase (HMGR) undergoes feedback-regulated degradatio

178 Thioredoxin (Trx) is a conserved, cytosolic reductase in all known organisms.

179 omplex, illuminating the role of nitrogenase reductase in altering the potential landscape in the act

180 suggesting that STEAP1 functions as a ferric reductase in STEAP heterotrimers.

181 Three of the four sterol reductases in cholesterol production, 7-dehydrocholester

182 nthine oxidoreductase, a nitrate and nitrite reductase, in cornea and sclera.

183 we conclude that the NO(2)-dependent nitrate reductase-independent pathway is crucial for NO producti

184 rimary analysis, genetically proxied HMG-CoA reductase inhibition equivalent to a 1-mmol/L (38.7-mg/d

185 tation carriers, genetically proxied HMG-CoA reductase inhibition was associated with lower ovarian c

186 -cell viability independently of thioredoxin reductase inhibition.

187 anged 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin) eligibility criteria for pr

188 s for 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin) therapy than middle-aged an

189 droxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin) treatment for dyslipidemia,

190 Dutasteride (5alpha-reductase inhibitor) is approximately 10-times more pote

191 GF1R) inhibitor, and fluvastatin, an HMG-CoA reductase inhibitor, as potential chemopreventive agents

192 rties, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have broad anti-inflammat

193 g the polyol influx by treatment with aldose reductase inhibitors normalized intracellular sorbitol l

194 However, only the pharmaceutical 5alpha-reductase inhibitors provoked the response.

195 Ribonucleotide reductase inhibitors such as gemcitabine also arrest cel

196 Statins are HMG-CoA reductase inhibitors that are known to inhibit cellular

197 (amphenicols, cephalosporins, dihydrofolate reductase inhibitors, fluroquinolones, macrolides, nitro

198 alpha-amylase, alpha-glucosidase and aldose reductase inhibitory activity were assessed.

199 sis indicates this NRPS-like glycine betaine reductase is highly conserved and widespread in kingdom

200 -glucosidase (K(i) = 166.9 ug/mL) and aldose reductase (K(i) = 127.5 ug/mL) through non-competitive m

201 The structure revealed that STEAP1 adopts a reductase-like conformation and interacts with the Fabs

202 Isoflavone reductase-like protein, S-adenosyl methionine synthase,

203 which evolved from the assimilatory nitrate reductase lineage.

204 ol 1,2-dioxygenase (CatA) and a muconic acid reductase (MAR) in Escherichia coli.

205 plex I, the elemental sulfur (S(0))-reducing reductase MBS.

206 Methyl-coenzyme M reductase (MCR) has been originally identified to cataly

207 e well-accepted mechanism, methyl-coenzyme M reductase (MCR) involves Ni-mediated thiolate-to-disulfi

208 The enzyme methyl-coenzyme M reductase (MCR) plays an important role in mediating glo

209 , a hypothetical protein (hp) and a mercuric reductase (MerA).

210 r1 regulates expression of two paralogous MG reductases, MGD1 and MGD2, and that both participate in

211 nzymes, among which are methionine sulfoxide reductase (Msr) enzymes, which are critical for bacteria

212 ic molybdenum-dependent methionine sulfoxide reductase (MsrP).

213 fertility status, methylenetetrahydrofolate reductase (MTHFR) genotype, and exposures.

214 Methylenetetrahydrofolate reductase (MTHFR) links the folate cycle to the methioni

215 vity of the enzyme methylenetetrahydrofolate reductase (MTHFR), and epigenetic regulation of the geno

216 ablation of 5,10-methylene tetrahydrofolate reductase (Mthfr), which results in retention of 1-carbo

217 ated by the cytoplasmic methionine sulfoxide reductase Mxr1 (MsrA) and a previously unidentified cyto

218 viously unidentified cytoplasmic pool of the reductase Mxr2 (MsrB).

219 Copper-containing nitrous oxide reductase (N(2)OR) is the only known enzyme to catalyze

220 senate reductase (arrA), periplasmic nitrate reductase (napA) and membrane-bound selenate reductase (

221 The specific activity of chromate reductase, NfoR, from Staphylococcus aureus sp. LZ-01 wa

222 selected the Escherichia coli nitro/quinone reductase NfsA for chloramphenicol detoxification by sim

223 d to proxy therapeutic inhibition of HMG-CoA reductase, Niemann-Pick C1-Like 1 (NPC1L1) and proprotei

224 syNOS retains the oxygenase (NOS(ox)) and reductase (NOS(red)) domains present in mammalian NOS en

225 in primary N assimilation, including nitrate reductase (NR) and alanine aminotransferase (AlaAT), wer

226 required for specific binding to the nitrate reductase (NR) promoter, NO production, and virulence in

227 Cytochrome c nitrite reductase (NrfA) catalyzes the reduction of nitrite to a

228 re controlled by the NADPH/NADPH thioredoxin reductase (NTR)/thioredoxin (TRX) and reduced GSH/GRX sy

229 The class Ia ribonucleotide reductase of Escherichia coli requires strict regulation

230 of parasites' survival enzyme trypanothione reductase of replicating amastigotes in hosts' reticuloe

231 negative relationship between the C14-sterol reductases; one enzyme or the other tends to be predomin

232 t tryptophan chlorinase Tar14 and its flavin reductase partner Tar15.

233 lyprenol to dolichol by an active polyprenol reductase (PfPPRD) in the malaria parasite.

234 mber 1, peroxisomal trans-2-enoyl-coenzyme A reductase, phospholipase A2 receptor, protein kinase C z

235 y on the same protein, NADPH-cytochrome P450 reductase (POR), to provide the electrons necessary for

236 ed protective factors, in particular alkenal reductase PTGR1 and methionine sulfoxide reductase.

237 -module NRPS, PpzA-1, which has a C-terminal reductase (R) domain that is required for reductive rele

238 The multicopper enzyme nitrous oxide reductase reduces the greenhouse gas N(2)O to uncritical

239 d other eukaryotic integral membrane steroid reductases remain elusive due to a lack of structural in

240 SNO-CoA reductases require NADPH, whereas enzymatic reduction of

241 eviously annotated short chain dehydrogenase/reductase, respectively, in Clostridium beijerinckii NCI

242 intermediate of the two best chloramphenicol reductases revealed complex epistatic interactions.

243 h when coexpressed with a P. marinus sulfite reductase, revealing that pssm2-Fd can transfer electron

244 and newly synthesized ubiquinol-cytochrome c reductase Rieske iron-sulfur polypeptide 1 (UQCRFS1), th

245 Ribonucleotide reductase (RNR) catalyzes the rate-limiting step of de n

246 Ribonucleotide reductase (RNR) is a central enzyme for the synthesis of

247 his reduction is catalyzed by ribonucleotide reductase (RNR), a heterodimeric tetramer enzyme in mamm

248 eletal muscle by inactivating ribonucleotide reductase (RNR), a key enzyme for the de novo production

249 Ribonucleotide reductase (RNR), which is a heterodimeric tetramer compo

250 Ribonucleotide reductases (RNRs) are a diverse family of enzymes that a

251 Ribonucleotide reductases (RNRs) catalyze the conversion of all four ri

252 Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nuc

253 Ribonucleotide reductases (RNRs) use a conserved radical-based mechanis

254 es demonstrate novel features of the mycolyl reductase Rv2509 and outline its role in mycobacterial g

255 verned by its cognate denitrosylase, SNO-CoA reductase (SCoR)(5).

256 to the short-chain fatty acid dehydrogenase/reductase (SDR) family, but with some distinct features

257 de a member of the short-chain dehydrogenase/reductase (SDR) superfamily, but its potential role in P

258 n or siRNA-mediated depletion of thioredoxin reductase sensitized beta-cells to continuously generate

259 n type 9, and 3-Hydroxy-3-Methylglutaryl-CoA Reductase single nucleotide polymorphisms known to be as

260 However, when the quinone reductase site is inhibited or the quinone pool is highl

261 gene that encodes for a putative superoxide reductase (SOR) enzyme.

262 anus ambivalens, including sulphur oxygenase reductase (SOR) that disproportionates S degrees into H(

263 ical trials, as well as succinate ubiquinone reductase (SQR) activity of Complex II, using thenoyltri

264 reductase (napA) and membrane-bound selenate reductase (srdA) respectively.

265 at flavinylation of a member of the fumarate reductase subfamily allows this enzyme to receive electr

266 s of hypoxia and in the presence of "nitrite reductases" such as heme- and molybdenum-containing enzy

267 erial Fds and reactivity with a host sulfite reductase suggest that phage Fds evolved to transfer ele

268 coded for enzymes belonging to the Nitro-FMN-reductase superfamily.

269 e antagonized by the thioredoxin/thioredoxin reductase system (Trx/TrxR).

270 bb (3)-Cox) assembly factor CcoG as a cupric reductase that binds Cu via conserved cysteine motifs an

271 ings indicate that AKR1A1 is a multi-LMW-SNO reductase that can distinguish between and metabolize th

272 econd enzyme CndE is a stereoselective imine reductase that gives 1.

273 in numerous species, uses a nitrogenase-like reductase that is distinct from known nitrogenases and n

274 in a conserved class of sulfite and nitrite reductases that catalyze the six-electron reduction of s

275 e depends on one-electron reduction, yet the reductases that catalyze this process in tumors are unkn

276 Interestingly, HMG-CoA reductase, the rate-limiting enzyme in cholesterol synth

277 ion of 3-hydroxy-3-methylglutaryl-coenzyme A reductase therapy in patients with cirrhosis despite dat

278 O(2) and during enzymatic (NADPH/thioredoxin reductase/thioredoxin) and chemical (DTT) turnover.

279 rther reduced in D. desulfuricans by glycine reductase to acetyl-P, and then to acetyl-CoA, which is

280 nt lines lacking peroxisomal hydroxypyruvate reductase to determine if there are connections between

281 hanging its oligomeric state and acting as a reductase to refill ER calcium stores.

282 rformed structure-guided mutagenesis of GalA reductases to change their cofactor preference from NADP

283 g the substrate scope of the carboxylic acid reductase toward noncognate omega-hydroxylic acids.

284 alpha-halo carbonyl compounds) and the 'ene' reductase triggers the enantioselective photoinduced rad

285 ves two electrons from NADPH via thioredoxin reductase (TrxR) and passes them on to multiple cellular

286 xidative phosphorylation via the thioredoxin reductase (TrxR) inhibitor, D9, and the Akt inhibitor, M

287 e for the selective detection of thioredoxin reductase (TrxR), an enzyme commonly overexpressed in me

288 s not occur naturally, catalysed by an 'ene' reductase using readily available alpha-halo carbonyl co

289 rxR) and passes them on to multiple cellular reductases via disulfide exchange.

290 Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating

291 Human vitamin K epoxide reductase (VKOR) is the target of warfarin.

292 anticoagulants that target vitamin K epoxide reductases (VKOR), a family of integral membrane enzymes

293 elative to the structurally related aldehyde reductase was recorded.

294 Genetically proxied inhibition of HMG-CoA reductase was significantly associated with lower odds o

295 nvironment; moreover, P. stutzeri dinitrogen reductase was transcribed in JGTA-S1 even under adequate

296 ycling to an array of C=O, C=N, and C=C bond reductases, we demonstrate asymmetric deuteration across

297 es, such as aldo-keto reductase and carbonyl reductase, were detected after H(2)O(2) exposure.

298 f Senescence (GVS1), with high similarity to reductase, where a single nonsynonymous nucleotide subst

299 ng Rnr1, the major subunit of ribonucleotide reductase, which converts ribonucleotides to deoxyribonu

300 olve direct cross-modular interaction of the reductase with the longer acyl chain, rather than back t