ライフサイエンスコーパス: reductive

1 t, applying CuH cascade catalysis to achieve reductive 1,1-difunctionalization of alkynes remains an

2 cylation/[3,3]-rearrangement process and the reductive 1,2-oxazine ring contraction into a pyrrolidin

3 Electrons from FDX2 catalyze the reductive [2Fe-2S] cluster fusion on ISCA1-ISCA2 in an I

4 Here, we report a cobalt-catalyzed reductive [5 + 1]-cycloaddition between a vinylcycloprop

5 metalloradicals bear great potential for the reductive activation of challenging substrates but are o

6 reductase activity (rv3547), indicating that reductive activation of the 3,5-dinitrobenzyl analogues

7 Binding of N(2) by nitrogenase requires a reductive activation of the FeMo-cofactor, but the preci

8 and uncover the photochemical mechanism for reductive activation of the nickel cocatalyst.

9 amin) is synthesized from cob(II)alamin in a reductive adenosylation reaction catalyzed by adenosyltr

10 one to provide a balance of accessibility to reductive agents necessary to ensure stability in transi

11 In this review, direct catalytic reductive aldol and Mannich reactions are exhaustively c

12 can be prepared on multigram scale by double reductive alkylation with melamine acetaldehyde, resulti

13 o complementary one-pot systems in which the reductive aminase (RedAm) from Aspergillus oryzae is com

14 efined polyurethane oligomers via sequential reductive amination and carbamation.

15 s review, we summarize the work published on reductive amination employing hydrogen as the reducing a

16 ries dealing with one or the other aspect of reductive amination have appeared.

17 The reductive amination is impressive with regard to the pro

18 two synthetic pathways: (1) using a titanium-reductive amination reaction affording a 50/50 mixture o

19 placement of reactive side chains during the reductive amination reaction.

20 A sequence of N,O-ketalization and reductive amination secured the chemoselectivity of N-me

21 of chiral Bronsted acid-catalyzed asymmetric reductive amination using a silane as the hydride source

22 ynthesis of tertiary alkylamines is carbonyl reductive amination(3), which comprises two elementary s

23 The reductive amination, the reaction of an aldehyde or a ke

24 attractive and include enzymatic asymmetric reductive amination, which offers an efficient route to

25 imary amino group at C-7 for conjugation via reductive amination.

26 during solid-phase peptide synthesis through reductive amination.

27 N-glycans at their free reducing terminus by reductive amination.

28 ound to chitosan by Schiff base reaction and reductive amination.

29 1 medical substances that are synthesized by reductive amination.

30 protocol uses a robustly diastereoselective reductive amination/aza-Michael reaction sequence to ach

31 In general, reductive aminations are challenging processes, especial

32 Reductive aminations constitute an important class of re

33 In addition, mechanisms of reductive aminations including selective formation of de

34 need for a comprehensive review on catalytic reductive aminations to discuss the potential catalysts

35 quently, in this review we discuss catalytic reductive aminations using molecular hydrogen and their

36 In particular, catalytic reductive aminations using molecular hydrogen are highly

37 viating the need for metal-catalysed abiotic reductive aminations.

38 ed charge carriers and the availability of a reductive and an oxidative quenching pathway.

39 ubsequent coupling (Ni) highlight the unique reductive and base compatibility of the -CF(2)H hydrogen

40 atalysts, respectively, indicating that both reductive and oxidative quenching catalytic cycles can b

41 elopmental biologists to move away from this reductive approach.

42 erizing enzymes for each of the steps in its reductive arm, revealing a strategy in which the A-B rin

43 ever, this led to the production of unwanted reductive aroma compounds in some wines.

44 c strategy expands the scope of Ni-catalyzed reductive asymmetric cross-coupling reactions.

45 he formation of SMSIR upon treatment under a reductive atmosphere.

46 O-Glycans were released by reductive beta-elimination and defined, showing a range

47 negative frequency dependence exists due to reductive Black Queen evolution that has resulted in a p

48 elimination of H(2) from dihydride 3 or via reductive C-H elimination from monohydride 2.

49 mechanistic description of an intermolecular reductive C-N coupling of nitroarenes and arylboronic ac

50 f nitromethane by organophosphorus-catalyzed reductive C-N coupling with arylboronic acid derivatives

51 e a two-stage deoxygenation sequence for the reductive C-N coupling.

52 terocycles through sequential intermolecular reductive C-N cross coupling with boronic acids, followe

53 or the first time, unlike O-O bond cleavage, reductive C-O bond cleavage in peroxides using the Pd ca

54 Model-derived rate coefficients and reductive capacities for the intact core microcosms alig

55 This was presumably due to depletion of reductive capacity (average values of 0.12 +/- 0.10 muee

56 UDP-G decreased the reductive capacity of nondiabetic human islets cultured

57 T2D donor islets displayed a lower reductive capacity when cultured at 5 mm glucose for 72

58 The mechanism of reductive carboxylation of alkyl halides has been propos

59 In cells with defective OXPHOS, reductive carboxylation replaces oxidative metabolism to

60 s by rebalancing redox cofactors, increasing reductive carboxylation, and promoting glycolysis.

61 ed antioxidant metabolic pathways, including reductive carboxylation, proline synthesis, and cystine

62 compensatory metabolic activities including reductive carboxylation.

63 ickel cathodes to probe the various paths of reductive catalytic C-O bond cleavage among functionaliz

64 on lignin-derived products obtained from the reductive catalytic fractionation of corn stover, deplet

65 We here demonstrate distance-dependent reductive charge transfer through RNA duplexes and throu

66 2.2-cryptand ligand (crypt) to explore their reductive chemistry.

67 a series of alpha-ketoacid analogues of the reductive citric acid cycle without the need for metals

68 During the reductive cleavage divisions, the rate of heat dissipati

69 bered P(=O)-CH(2)-B compound, the product of reductive cleavage of carbon monoxide.

70 In nearly all of these reactions, the reductive cleavage of SAM is proposed to produce a react

71 ster that all family members require for the reductive cleavage of SAM to afford the common 5'-deoxya

72 silyl radicals through energetically uphill reductive cleavage of strong Si-Cl bonds.

73 proceeds by Criegee ozonolysis of an alkene, reductive cleavage of the resulting alpha-alkoxy hydrope

74 ical that undergoes regioselective homolytic reductive cleavage of the S-C5' bond to generate the 5'-

75 were released by derivatization followed by reductive cleavage, a chemical degradative method that c

76 -active ligands play a key role in promoting reductive CO dissociation during catalysis.

77 the activation of unsaturated substrates via reductive concerted proton-electron transfer (CPET) must

78 , a broad-spectrum metallophore, through the reductive condensation of a pathway intermediate (xNA) w

79 Reductive condensation of o-nitrobenzaldehydes with amin

80 In the hunt for an organocatalyst, reductive conditions were applied to the Schiff base to

81 -catalyzed benzalkyl C-N bond cleavage under reductive conditions.

82 Cu-based catalyst promotes both the initial reductive coupling and subsequent cyclization steps.

83 rbonyl arylations via transfer hydrogenative reductive coupling are described.

84 thus offering new vistas in the Ni-catalyzed reductive coupling arena while providing an unconvention

85 Titanium alkoxide-based alkyne-alkyne reductive coupling mediated by in situ generated arylami

86 The reductive coupling of a N-heterocyclic carbene (NHC)-sta

87 cal, scalable, and broadly applicable to the reductive coupling of a wide range of aryl, heteroaryl,

88 The dinuclear bis-hydride 2 effects the reductive coupling of acetonitrile by hydride transfer t

89 identification of a single-electron-promoted reductive coupling of acyl azolium species.

90 fied by (t)Bu(2)PMe, sodium formate-mediated reductive coupling of aryl iodides with aldehydes occurs

91 Catalytic reductive coupling of enone, acrylate, or vinyl heteroar

92 The macrocyclic ligand is generated by the reductive coupling of the imino groups of three salophen

93 H Lewis pair reacted with carbon monoxide by reductive coupling of two CO molecules at the template.

94 An amino acid-catalyzed three-component reductive coupling protocol has been developed for the s

95 ormations include iridium-catalyzed carbonyl reductive coupling to form the quaternary C4 stereocente

96 catalytic amount of an Fe(II) salt, to a net reductive coupling.

97 se of simple C(sp(2))-SMe to be engaged in a reductive coupling.

98 carbamate directing effect in metal-mediated reductive coupling.

99 f this ligand allowed expanding the scope of reductive couplings to challenging substrates, such as s

100 outcome in these "asymmetric radical relayed reductive couplings" (ARRRCs).

101 ations, polymerizations, hydrogenations, and reductive couplings, among others.

102 lar mediator for electrochemically triggered reductive CPET through the synthetic integration of a Br

103 Inspired by the advantages of reductive cross-coupling approaches, we present here a h

104 l/organic photoredox co-catalyzed asymmetric reductive cross-coupling between alpha-chloro esters and

105 A photoassisted Ni-catalyzed reductive cross-coupling between tosyl-protected alkyl a

106 This reductive cross-coupling reaction displays a fairly unus

107 nic reductant (Hantzsch ester), whereas most reductive cross-coupling reactions use stoichiometric me

108 -complexes proposed in numerous Ni-catalyzed reductive cross-coupling reactions-has been subject to s

109 alytic cycles can be operative, although the reductive cycle is favored.

110 alladium-catalyzed, carbon monoxide mediated reductive cyclization of 1,4-dialkenyl-2,3-dinitrobenzen

111 ereby, providing an unprecedented example of reductive cycloaddition reactivity in the chemistry of 2

112 More interestingly, after the reductive debonding, the resulting metal surface with fr

113 e been found to generate alkyl radicals upon reductive decarboxylation of redox-active esters without

114 ng Dehalococcoides mccartyi (Dhc) growth and reductive dechlorination in enrichment cultures derived

115 When in situ TCE reductive dechlorination is stimulated by the addition o

116 Biostimulation to promote reductive dechlorination is widely practiced, but the va

117 The reductive dechlorination of other chlorinated compounds

118 activity and selectivity of SNZVI during the reductive dechlorination of trichloroethylene (TCE), a h

119 and green electrode material was studied in reductive dechlorination processes.

120 ction of RDases peptides indicating specific reductive dechlorination steps.

121 C(6) per- and polyfluorinated compounds via reductive defluorination by an organohalide-respiring mi

122 wn for the other organohalides, no microbial reductive defluorination has been documented for perfluo

123 ustness screening experiment shows that this reductive defluorination tolerates a range of functional

124 The reductive defluorination was demonstrated by the release

125 n the community might be responsible for the reductive defluorination.

126 luorinated products that are recalcitrant to reductive defluorination.

127 yi (Dhc) bacterial strains expressing active reductive dehalogenase (RDase) enzymes play key roles in

128 s with vitamin B(12) as a model reactant for reductive dehalogenase activity.

129 The genome of strain GEO12 revealed seven reductive dehalogenase homologous (rdh) genes, including

130 ers, the presence of genes encoding putative reductive dehalogenases throughout the phylum expanded t

131 ides or active expression of Dehalococcoides-reductive dehalogenases was observed.

132 xpand our fundamental knowledge of microbial reductive dehalogenation and warrant further studies on

133 Although microbial reductive dehalogenation is well known for the other org

134 Furthermore, the HE anion induces reductive dehalogenation reaction of aryl halides under

135 recently found that EREDs can also catalyse reductive dehalogenations and cyclizations via single el

136 The synthesis involves reductive deposition of rhodium or platinum and oxidatio

137 quantum dots (QDs) as photocatalysts for the reductive deprotection of aryl sulfonyl-protected phenol

138 TP diastereomers as documented here, but the reductive deprotection step is not compatible with dCTP

139 e [3 + 2] product is also shown to undergo a reductive desymmetrization process to access chiral cycl

140 cient asymmetric intermolecular Ni-catalyzed reductive dicarbofunctionalization of alkenes.

141 Herein we describe the advent of a reductive diselenide-selenoester ligation (rDSL) method

142 indicate that reactive iron minerals undergo reductive dissolution inside anoxic microsites of primar

143 and hence, the contribution of O(2)(*)(-) to reductive dissolution of AFO is dependent on conditions

144 s an electron donor for microbially-mediated reductive dissolution of As-bearing Fe(III) (oxyhydr)oxi

145 -Holocene (>12 kyr-old) aquifer promotes the reductive dissolution of iron oxides and the release of

146 ing of sulfidic conditions and subsequent Fe reductive dissolution.

147 3.2.1]octanes (bridged 1,3-diazepanes) via a reductive diversion of the Minisci reaction.

148 t starts with cleavages, a rapid sequence of reductive divisions that result in an exponential increa

149 Recently, photolytic reductive elimination (re) of the E(4)(4H) hydrides show

150 ia glutathione-dependent alkyltransferase or reductive elimination activities.

151 4)PPh(2))(ZnMe)] (5), that is formed via C-H reductive elimination and features unsaturated Ru and Zn

152 Oxidative addition and reductive elimination are defining reactions of transiti

153 s and fluorine effect-induced regioselective reductive elimination are independently involved to enab

154 l as less electron-rich ligands accelerating reductive elimination as a nitronate-specific mechanism.

155 The energetic span analysis reveals the reductive elimination as the turnover determining step f

156 l analogue underwent C(sp(3))-N bond-forming reductive elimination at 140 degrees C in DMF to afford

157 g oxidative addition, ligand metathesis, and reductive elimination at a C(s)-symmetric phosphorus tri

158 ower barrier for C-CN oxidative addition and reductive elimination at benzylic positions in the absen

159 he steric environment can be used to promote reductive elimination at carbon centers.

160 C-C reductive elimination from [PdL(2)(C(6)F(5))(2)] to form

161 of an unprecedented and fast aryl C(sp(2))-X reductive elimination from a series of isolated Pt(IV) a

162 to undergo a subsequent transmetalation and reductive elimination from either an in situ formed fluo

163 Among the computed mechanisms, the reductive elimination from the C-bound enolate Pd comple

164 the oxidant to promote the desired selective reductive elimination from the Pd(IV) centre, as well as

165 (a) of the Ni-bound amine and the barrier to reductive elimination from the resultant Ni(II)-amido co

166 ion" highlights the ability of Zn to promote reductive elimination in these heterobimetallic systems.

167 ents suggest the mechanism of the subsequent reductive elimination is a unimolecular process occurrin

168 Reductive elimination is an elementary organometallic re

169 s show the oxidative addition/intramolecular reductive elimination likely to be the lowest-energy pat

170 d uptake and deprotonation could not undergo reductive elimination meaning a "dead-end route".

171 hed oxidative addition, transmetalation, and reductive elimination mechanistic paradigm, would potent

172 is presented to support that this dinuclear reductive elimination occurs by tautomerization of the m

173 Turnover-limiting C-C reductive elimination occurs from a spectroscopically ob

174 f the latter suggests that a C(sp(3))-I bond reductive elimination occurs preferentially to any other

175 Heating of 1.[H][Ar(F)] regenerates 1 by C-H reductive elimination of Ar(F)-H, where experimental and

176 late-Ni(III)-H species undergoes bimolecular reductive elimination of H(2).

177 n of the coordinated bond and the subsequent reductive elimination of H(2).

178 Then, the subsequent C-C reductive elimination of the regioselective linear produ

179 e well-suited for catalytic cycles involving reductive elimination or oxidative addition as a limitin

180 supramolecular capsule Ga(4)L(6)(12-) on the reductive elimination reaction from gold complexes and a

181 upports the transition state to complete the reductive elimination reaction with greater catalytic ef

182 idative addition is now well-established but reductive elimination reactions are not yet general in t

183 The C(sp(2))-X reductive elimination reactions of all isolated Pt(IV) c

184 ion state, rather than an oxidative addition/reductive elimination sequence, as we proposed in the ca

185 leads to an overall reduced barrier for the reductive elimination step compared to the formation of

186 cross-coupling products via an outer-sphere reductive elimination step via triplet spin state from t

187 ability of Zn to promote a rate-limiting C-H reductive elimination step, and calculations attribute t

188 iments were consistent with unimolecular C-C reductive elimination that occurred either by a concerte

189 Reductive elimination therefrom provides bis-heteroaryl

190 llographic analysis revealed that a putative reductive elimination to forge C(sp(3))-OC(sp(3)) using

191 , and the rate-limiting step was shown to be reductive elimination to form the C-C bond.

192 C, consistent with irreversible unimolecular reductive elimination to form the cyclobutane product.

193 ansferring hydrogen in the rate-limiting C-H reductive elimination transition states.

194 ws that Fro-DO accelerates turnover limiting reductive elimination via LUMO lowering.

195 echanistic study of the nucleophile-mediated reductive elimination was conducted using an oxime-deriv

196 nt Ni(IV) complexes, aryl-CF(3) bond-forming reductive elimination was reported to occur readily.

197 ither ligand-coupling or S(N)2 displacement (reductive elimination), and this is shown to be substrat

198 e nitroalkane enolates is attributed to slow reductive elimination, a consequence of the hard nature

199 e elusive synthesis of diethyl ether through reductive elimination, a remarkable feature currently be

200 ntermediates by oxidative addition and their reductive elimination, are much better understood.

201 nsformations, such as oxidative addition and reductive elimination, are two-electron processes and es

202 insertion into the M-H bond, followed by P-C reductive elimination, or by insertion into the M-P bond

203 n, or by insertion into the M-P bond and C-H reductive elimination.

204 n and transmetalation, and CCl(3) CN-induced reductive elimination.

205 te transmetallation and the C-C bond-forming reductive elimination.

206 y to bind and facilitate C(sp(3) )-C(sp(3) ) reductive elimination.

207 wed by intramolecular oxidative addition and reductive elimination.

208 eps: radical addition-SET-oxidative addition-reductive elimination.

209 rior to undergoing irreversible inner-sphere reductive elimination.

210 erentially to any other challenging C-O bond reductive elimination.

211 he photocatalyst is only involved to trigger reductive elimination.

212 ate at reducing the barrier to Csp(3)-Csp(3) reductive elimination.

213 K-enolate generated in situ, and subsequent reductive elimination.

214 sing Ir(ppy)(3) supports a turnover-limiting reductive elimination.

215 as a stereochemical reporter for reversible reductive elimination/oxidative addition chemistry invol

216 The reversible H(2) and C-H reductive elimination/oxidative addition equilibrium smo

217 migratory insertion, oxidative addition, and reductive elimination; it accounts for conformational sa

218 They are usually obtained in a reductive environment as molecular O(2) can oxidize Ru(I

219 confer reduction resistance to withstand the reductive environment within cells.

220 at the solid/electrolyte interface to mimic reductive environments, and simultaneously probe the str

221 es is portrayed involving a radical-mediated reductive epoxide opening reaction of N-tethered epoxy-i

222 ing improper disulfide bond formation during reductive ER stress but did not bind to this protein dur

223 NRVMs increased cell death from DTT-mediated reductive ER stress, but not from nonreductive ER stress

224 protein folding and myocyte viability during reductive ER stress.

225 ss in the ER, we examined the effects of the reductive ER stressor DTT.

226 of evolution in the animal kingdom in which reductive evolution at the protein-coding level played a

227 om primordial, precellular genetic elements, reductive evolution from cellular ancestors and escape o

228 The presented structure highlights the reductive evolution in these emerging pathogens and shed

229 e current paradigm and turn attention to the reductive evolution of peroxisomes in anaerobic organism

230 hat the stomata of bryophytes have undergone reductive evolution, including their complete loss from

231 t can be paired with H(2) evolution or other reductive fuel production reactions in electrochemical a

232 expand the scope of electrochemistry to the reductive functionalization of alkenes.

233 or the synthesis of alpha-branched amines by reductive functionalization of tertiary carboxamides and

234 ction techniques, both one- and two-electron reductive functionalization of the uranyl oxo groups has

235 visible-light absorptivity of Eosin Y for a reductive generation of alkyl radicals from N-(acyloxy)p

236 , including activation of AMPK, the PPP, and reductive glutamine and folate metabolism.

237 t D. desulfuricans assimilates CO(2) via the reductive glycine pathway, a seventh CO(2) fixation path

238 DFT calculations show lowers the barrier for reductive H(2) elimination from the bimetallic cleft.

239 I)-H)(2)](-) (3) are prone to intramolecular reductive H(2) elimination, and an equilibrium between 3

240 construction of a detailed mechanism for the reductive half-reaction of glycine oxidation.

241 The reductive half-reaction, requiring the interaction with

242 oped a transient-directing-group approach to reductive Heck hydroarylation of alkenyl benzaldehyde su

243 native RuBisCO-mediated CO(2) reduction (the reductive hexulose-phosphate (RHP) pathway) is transcrip

244 A transition-metal-free reductive hydroxymethylation reaction has been developed

245 vements averts irreversible NO poisoning and reductive inactivation of the enzyme.

246 GD/RNP, which can be readily released in the reductive intracellular milieu as a result of the cleava

247 The reaction proceeds via a reductive iodonium Claisen rearrangement of in situ-gene

248 n a domino mode involving Mo(CO)(6)-mediated reductive isoxazole ring-opening, Mo(CO)(6)-catalyzed ci

249 es via "cyanide Michael addition/methylation/reductive isoxazole-pyrrole transformation" is developed

250 ectrolyte is the key to stabilize the highly reductive lithium (Li) metal anode and the high-voltage

251 of biological reduction compatible with non-reductive materialism.

252 However, reductive metabolism by the mARC enzyme system can play

253 We found that cell viability and reductive metabolism for both cell lines are kept close

254 n of the oxo ligands into siloxy ligands and reductive metalation of the uranyl oxo with Group 1 and

255 ative capacity in situ and routinely undergo reductive mitoses during regenerative responses.

256 hly efficient as recyclable catalysts in the reductive N-alkylation of arylamines under mild conditio

257 The direct reductive N-arylation of nitromethane by organophosphoru

258 e catalyst in both CO(2) hydrosilylation and reductive N-functionalization of amines using CO(2) as t

259 the most abundant reactant of intracellular reductive-oxidative metabolic cycles in cells and can re

260 Therapies targeting reductive/oxidative (redox) metabolism hold potential in

261 This common intermediate could then follow a reductive path toward a dehydropiperidine, as in the thi

262 The reductive potential of the cellulose- and antioxidant-ri

263 s, metal-carbene bonds that are stable under reductive potentials prevent the nanoclustering of nanop

264 ow the compacted plough pan, suggesting that reductive processes mobilize P.

265 reactive organometallic species that mediate reductive proton-coupled electron transfer (PCET) reacti

266 ter have proven to be useful reagents in the reductive protonation of small-molecule substrates, incl

267 Reductive protonation reactions with these compounds con

268 ust target materials that combine both rapid reductive quenching and rapid charge transfer to a metal

269 comparison shows that P10 exhibits efficient reductive quenching but slow electron transfer to residu

270 With the aid of a simple reductive quenching photoredox cycle, we have successful

271 f long-lived electrons due to more efficient reductive quenching.

272 and benzylic C(sp(3))-H oxygenation through reductive quenching.

273 mto-nanosecond time scale, thus outcompeting reductive quenching.

274 e reductant, this process operates through a reductive radical-polar crossover mechanism where aryl h

275 The maximum magnitude of reductive redox work is also material dependent: metalli

276 of nuclear waste temporal evolution and the reductive remediation of uranium contamination.

277 this unusual reactivity centered around the reductive silylation of the uranyl ion which entailed co

278 A remote catalytic reductive sp(2) C-H carboxylation of arenes with CO(2) (

279 rated electrolytes can improve the oxidative/reductive stability, but encounter high viscosity.

280 By one reductive step catalyzed by GalA reductases, GalA is con

281 converted into an electron acceptor for two reductive steps carried out by Fe-S flavoenzymes.

282 pecific carbon sources, functions to counter reductive stress associated with acidic pH.

283 lactate:pyruvate ratio, we hypothesized that reductive stress could be alleviated by oxidizing extrac

284 rmation and such impairment can be caused by reductive stress in the ER, we examined the effects of t

285 Using LbNOX, we demonstrate that NADH reductive stress mediates the effects of GCKR variation

286 The reductive stress response is therefore built around a ub

287 ts substrate FNIP1 as core components of the reductive stress response.

288 levated intracellular NADH:NAD(+) ratio, or 'reductive stress', has been associated with multiple dis

289 larly sensitive to added energy supply (i.e. reductive stress), which exponentially increases the rat

290 Reductive stress, as caused by prolonged antioxidant sig

291 The coupling of reductive stress-induced JH(2)O(2) production to NNT-lin

292 c cytosolic NADH/NAD(+) ratio, also known as reductive stress.

293 on of the [2.2]paracyclophane according to a reductive sulfanylation reaction, which proceeds under t

294 Reductive termination of the photocatalytic cycle genera

295 phenylthiobutenolide via a tandem annulation/reductive thiolation reaction.

296 terminal alkynes is accomplished through the reductive three-component coupling of terminal alkynes,

297 fuel reprocessing activity, specifically the reductive trapping of the volatile and highly reactive R

298 and computer simulations demonstrate initial reductive treatment followed immediately by demographic

299 decouple MmOGOR from its native role in the reductive tricarboxylic acid cycle and drive it directly

300 hrough oxidative diazidation combined with a reductive work-up, without the need to isolate the poten