ライフサイエンスコーパス: reductive amination

1 epsilon-amino group of Lys in a peptide via reductive amination.

2 yl pyrroles that cannot be made via standard reductive amination.

3 imary amino group at C-7 for conjugation via reductive amination.

4 during solid-phase peptide synthesis through reductive amination.

5 tion reaction with N-Boc-ethylenediamine via reductive amination.

6 g the conjugation of the antigens to KLH via reductive amination.

7 oup manipulations followed by ozonolysis and reductive amination.

8 reptococcal type III polysaccharide (III) by reductive amination.

9 direct, covalent coupling of II CPS to TT by reductive amination.

10 N-glycans at their free reducing terminus by reductive amination.

11 sulting in III-alpha2r conjugate vaccine) by reductive amination.

12 re coupled with 2-(dansylamido)ethylamine by reductive amination.

13 e modified with 2-(dansylamido)ethylamine by reductive amination.

14 isulfonate (APTS) at the reducing termini by reductive amination.

15 ound to chitosan by Schiff base reaction and reductive amination.

16 dy of using NaH(2)PO(2) in the catalyst-free reductive amination.

17 nitrogen precursor through iridium-catalyzed reductive amination.

18 where olivine is partly hydrated, to mediate reductive amination.

19 1 medical substances that are synthesized by reductive amination.

20 or C-H bond oxyfunctionalization and 70% for reductive amination.

21 he most widely used C-N coupling reaction is reductive amination.

22 alysis to include nucleobase N-alkylation by reductive amination.

23 vated conjugate alkene reduction followed by reductive amination.

24 he pharmaceutical industry are performed via reductive amination.

25 ethylation beyond classical hydroformylation/reductive amination.

26 nd subsequent one-pot catalytic deprotection-reductive amination.

27 trolled copper-catalyzed 1,4-addition, and a reductive amination.

28 label the amine groups on the monoamines via reductive amination.

29 ng agents that are typically associated with reductive aminations.

30 f this alternative to conventional synthetic reductive aminations.

31 viating the need for metal-catalysed abiotic reductive aminations.

32 plings, benzimidazole-forming reactions, and reductive aminations.

33 of [4 + 2] cycloadditions, N-acylations, and reductive aminations.

34 ynthesis of tertiary alkylamines is carbonyl reductive amination(3), which comprises two elementary s

35 Reductive amination afforded the desired N-methylated [2

36 Further elaboration by ozonolysis and reductive amination affords 2b in an overall yield of 28

37 which are characteristic of the Leuckart and reductive amination (Al/Hg) methods of preparation.

38 be efficient reagents for a one-pot, tandem reductive amination/alkylation-cycloamidation of keto or

39 Three different bioconjugation techniques, reductive amination, amidation, and Huisgen cycloadditio

40 ) to allow for further functionalization via reductive amination, amidation, or other chemistry.

41 Final reductive amination and acetonide deprotection provided

42 efined polyurethane oligomers via sequential reductive amination and carbamation.

43 GSK852A (1) was obtained after reductive amination and mesylation with conditions amena

44 t the development of formal anti-Markovnikov reductive amination and oxidative hydration reactions to

45 nonradioactive standards were synthesized by reductive amination and subsequent alkylation of protect

46 nder modified conditions lead to an apparent reductive amination and the formation of o-hydroxybenzyl

47 tivity parameters of ICL formation by double reductive amination and yield a set of diverse ICLs that

48 oxy-Cope rearrangement, a one-pot ozonolysis-reductive amination, and a Lewis acid promoted cyclizati

49 ep protocol involving a Staudinger reaction, reductive amination, and benzyloxy carbonyl protection y

50 ibrary of ionizable, degradable lipids using reductive amination, and evaluate their delivery potenti

51 rate that thiophosphate allows photochemical reductive aminations, and that thiophosphate chemistry a

52 The reactions of reductive amination are of paramount importance as tools

53 In general, reductive aminations are challenging processes, especial

54 atowicz rearrangement, Michael addition, and reductive amination as key steps.

55 lizing a syn-selective Grignard addition and reductive amination as the key reactions.

56 rtwig, Ullmann, and classical amine-carbonyl reductive aminations, as it tolerates aryl halides and c

57 This protocol achieves selective reductive amination at 25 degrees C and 1 atm, providing

58 coccus capsular polysaccharide was linked by reductive amination at multiple sites to tetanus toxoid

59 and of reactions (nucleophilic substitution, reductive amination, aza-Michael addition, addition to e

60 protocol uses a robustly diastereoselective reductive amination/aza-Michael reaction sequence to ach

61 ormaldehyde and sodium cyanoborohydride, the reductive amination-based method can be utilized to gene

62 (2)ZrHCl (Schwartz's reagent), followed by a reductive amination between the resulting hemiaminal and

63 ion: Purely ferrous hydroxides did not drive reductive amination but instead promoted pyruvate reduct

64 for a high yield library of compounds via a reductive amination by flow hydrogenation.

65 oligosaccharides by conjugation to ADHP, by reductive amination, can be detected and quantified by s

66 cells primarily assimilated ammonia through reductive amination catalyzed by glutamate dehydrogenase

67 Reductive amination chemistry was used to synthesize all

68 We also describe optimized reductive amination conditions for linking 5'-aldehyde-D

69 Subsequently, when subjected to reductive amination conditions, each of these tetralones

70 ting unprotected lysine to the host-mediated reductive amination conditions, we observed excellent e-

71 Reductive aminations constitute an important class of re

72 Importantly, we showed that Ir-catalyzed reductive amination could be applied inside living cells

73 fied vancomycin ABCD ring system featuring a reductive amination coupling of residues 4 and 5 for ins

74 While carbonyl reductive amination (CRA) between ketones and alkylamine

75 ns, ketone reduction, sulfide oxidation, and reductive amination, culminating in the direct asymmetri

76 d isolated metal sites that allow for tandem reductive amination-deuteration sequences.

77 Complementary to known reductive aminations, effective C-N bond construction pr

78 The asymmetric ruthenium-catalyzed reductive amination employing ammonia and hydrogen to pr

79 s review, we summarize the work published on reductive amination employing hydrogen as the reducing a

80 d by using a two-step sequence consisting of reductive amination followed by urea coupling from comme

81 Glycans are usually fluorescently tagged by reductive amination for analytic tools.

82 Reductive amination forms products without modifying the

83 ries dealing with one or the other aspect of reductive amination have appeared.

84 A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparati

85 ation on an aldehyde-active solid support by reductive amination; (ii) stabilization of fragile siali

86 th 2-aminoacridone (2-AMAC), using classical reductive amination in a nonaqueous solvent, led to the

87 odium periodate, and conjugated to CRM197 by reductive amination in dimethyl sulfoxide.

88 residues and aliphatic chains to mannose via reductive amination in order to increase both the affini

89 an form in hydrothermal systems, can undergo reductive amination in the presence of mixed-valence iro

90 -OH, hydrogenolysis of the C(B) -O bond and reductive amination in the presence of Pd/C catalyst.

91 MSCN, CO(2) fixation by epoxides, and direct reductive amination in the presence of syngas.

92 In addition, mechanisms of reductive aminations including selective formation of de

93 by chiral auxiliary removal, ozonolysis, and reductive amination/intramolecular nucleophilic displace

94 The reductive amination is impressive with regard to the pro

95 Asymmetric reductive amination is one of the most efficient and ato

96 Reductive amination is one of the most important methods

97 Given its relevance across numerous fields, reductive amination is one of the oldest and most widely

98 Sequential enzymatic aldol reaction and bis-reductive amination leads to the total syntheses of tetr

99 thod and one route specific impurity for the reductive amination method are reported.

100 hloride were synthesized by the Leuckart and reductive amination methods (20 batches per method).

101 e, we immobilized glycoproteins on resin via reductive amination, modified alpha2,6-linked sialic aci

102 central 5'-CAp sequence under conditions of reductive amination (NaCNBH(3), pH 5.2) generated much h

103 e irreversibly converted under conditions of reductive amination (NaCNBH(3)/pH 5.2) to a stable amine

104 -alkyne, tetrazine-trans-cyclooctene, oxime, reductive amination, native chemical ligation, Suzuki, S

105 bio-based aliphatic amines via the catalytic reductive amination of (hemi)cellulose-derived substrate

106 Reductive amination of 15 with the appropriate benzaldeh

107 Reductive amination of 19 with 3,4,5-trimethoxyaniline a

108 synthesis of analogues 2-4 was achieved via reductive amination of 2,4-diamino-5-methyl 6-carboxalde

109 Reductive amination of 2-formylphenylmethane sulfonamide

110 Herein, we report the highly selective reductive amination of a broad range of aldehydes and ke

111 nthetic route to compounds 5-12 involved the reductive amination of a common intermediate, 2,4-diamin

112 irst example of an intramolecular asymmetric reductive amination of a dialkyl ketone with an aliphati

113 Stannous chloride catalyzed chemoselective reductive amination of a variety of carbonyl compounds w

114 Direct reductive amination of a wide range of ketones has been

115 wines, dry table wines, and wine spirits by reductive amination of aldehyde 2,4-dinitrophenylhydrazo

116 The key step involved rapid reductive amination of aldehyde 8 with aniline 5 by sodi

117 Solvent-free reductive amination of aldehydes and ketones with alipha

118 structing the diazepanone ring system: (a) a reductive amination of an epoxy aldehyde with N-methylam

119 p to 96% ee) were achieved in the asymmetric reductive amination of aryl ketones in the presence of T

120 The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an irid

121 e revealed here to be good catalysts for the reductive amination of benzaldehydes using formate salts

122 Asymmetric reductive amination of beta-keto amides catalyzed by the

123 The synthesis of organic amines via reductive amination of biomass-derived carbonyl compound

124 The aminotransferase OxyQ catalyzes the reductive amination of C4-keto of 2, yielding 4-amino-AT

125 of Mycobacterium tuberculosis catalyzes the reductive amination of glyoxylate to glycine but not the

126 responsible for the physiologically relevant reductive amination of glyoxylate.

127 The direct asymmetric reductive amination of heteroaryl ketones has been a lon

128 ogues 14 and the phenols 15 were obtained by reductive amination of ketones 13 and 6, respectively.

129 They are often prepared by the classical reductive amination of ketones and aldehydes, a staple r

130 n both neutral and oxidizing atmospheres, so reductive amination of nitrate and glyoxylate on a ferro

131 Reductive amination of oligosaccharides with fluorophore

132 The reductive amination of polymer-bound linkers by amines a

133 The asymmetric direct reductive amination of prochiral ketones with aryl amine

134 tri(picolyl) derivative was synthesized via reductive amination of pyridine carboxaldehyde.

135 activity at about 82 degrees C (203 U/mg for reductive amination of pyruvate) yet still retained 30%

136 e oxidative deamination of L-alanine and the reductive amination of pyruvate.

137 Reductive amination of repromicin with polyfunctional am

138 Double reductive amination of the 1,4-dicarbonyl (from the gamm

139 Double reductive amination of the 1,5-dicarbonyl (from the delt

140 ation with glycolaldehyde followed by tandem reductive amination of the 2-oxoethyl intermediate 4.

141 respectively, the combination of a chemical reductive amination of the 4-carboxyindanone followed by

142 fin and then the production of amine through reductive amination of the aldehyde.

143 The key steps in the synthesis are the reductive amination of the alpha,beta-unsaturated aldehy

144 theses of the analogues were accomplished by reductive amination of the appropriate anilines with 2-a

145 Compounds 3-5 were prepared by reductive amination of the appropriate anilines with 8-o

146 -H analogues were obtained via regiospecific reductive amination of the appropriate benzaldehydes wit

147 Reductive amination of the common intermediate 2,4-diami

148 s capable of producing d-amino acids via the reductive amination of the corresponding 2-keto acid wit

149 by employing a simultaneous Zn reduction and reductive amination of the resulting aldehyde.

150 the resulting nitrogen intermediate, and (4) reductive amination of the tetrahydroquinoline with form

151 Double reductive amination of two molecules of aldehyde 29 with

152 o a symmetrical diketone precursor, a double reductive amination of which forges its central piperidi

153 Using either reductive amination or amine acylation chemistries, we o

154 lylacetone followed by hydride reductions or reductive amination, or by Curtius degradations of alpha

155 o undergo homologation to a terminal alkyne, reductive amination, oxidation and olefination.

156 Reductive amination plays a paramount role in pharmaceut

157 ed propylamines in a one-pot hydrosilylation/reductive amination process.

158 20R,25R or 20R,25S products while the direct reductive amination produced the 20S,25R compound (25-ep

159 We developed a sustainable three-component reductive amination protocol for the chemoselective coup

160 oborates to the corresponding amines through reductive amination protocols.

161 into the target compounds via reduction and reductive amination protocols.

162 ldehyde 7 is subjected to a ring closure via reductive amination, providing 1b in an overall yield of

163 two synthetic pathways: (1) using a titanium-reductive amination reaction affording a 50/50 mixture o

164 The feasibility of the triple-reductive amination reaction for the synthesis of comple

165 An intramolecular reductive amination reaction has been used to prepare mo

166 k, we develop an alternative electrochemical reductive amination reaction that can proceed in neutral

167 placement of reactive side chains during the reductive amination reaction.

168 thout hydroxyl group protection via a simple reductive amination reaction.

169 e, trisaccharide, or heptasaccharide) in the reductive amination reaction.

170 e featuring an iterative double ring-closing reductive amination reaction.

171 N7-guanine-conjugated DPCs were generated by reductive amination reactions between the Lys and Arg si

172 The reductive amination reactions were essentially complete

173 ncies in bioconjugations, as demonstrated in reductive amination reactions with Streptavidin.

174 The amines are useful for acylation and reductive amination reactions, and the thiols participat

175 The kinetics of the reductive amination reactions, performed at 37 degrees C

176 two protecting groups and two intramolecular reductive amination reactions.

177 he tricarbonyl precursors for the key triple reductive amination reactions.

178 A sequence of oxidative cleavage/reductive amination/reductive cleavage enables the prepa

179 nts support the reaction occurring through a reductive amination/reductive Stieglitz cascade, via a k

180 n batches synthesized using the Leuckart and reductive amination routes.

181 A sequence of N,O-ketalization and reductive amination secured the chemoselectivity of N-me

182 ers, and a one-pot oxidative olefin cleavage/reductive amination sequence that closes the piperidine

183 monstrated through a deprotection and double-reductive amination sequence to give 4,5,6,7-tetrahydrop

184 motif and was further extended to a one-pot reductive amination sequence.

185 ed by a rhodium diphosphine complex, and the reductive amination step, which is conducted as a transf

186 nt alcohol oxidation and bioelectrocatalytic reductive amination steps based on an engineered choline

187 ocatalytic C-H bond oxyfunctionalization and reductive amination steps with neutral red (NR) as elect

188 compound, and the description is focused on reductive amination steps.

189 ion of epimerization in the O-alkylation and reductive amination steps.

190 The synthetic sequence included reductive amination, stereoselective epoxidation, intram

191 formations including nucleophilic additions, reductive aminations, Stille couplings, and polymer-assi

192 Two complementary reductive amination strategies employing either aldehyde

193 otected phenylalanine, and an intramolecular reductive amination strategy used to convert the coupled

194 A similar intramolecular reductive amination strategy was used to synthesize a su

195 ethod and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequen

196 reaction conditions relating to the Pt/H(2) reductive amination synthesis were, for the first time,

197 nctionalization, intermediate oxidation, and reductive amination, the bioelectrocatalytic hydrocarbon

198 e bond formation, Suzuki cross-coupling, and reductive amination, the Buchwald-Hartwig-Ullmann-type a

199 The reductive amination, the reaction of an aldehyde or a ke

200 for a Curtis/acylation sequence and a novel reductive amination/thermal lactamization to circumvent

201 s from Kme(2) were then functionalized using reductive amination, thiolamine, and oxime chemistry.

202 The visible dye was coupled by a reductive amination to different sugars.

203 We also observed reductive amination to form alanine and reduction to for

204 f 3-pyrroline to perform the equivalent of a reductive amination to form alkyl pyrroles.

205 A diformylbacteriochlorin was subjected to reductive amination to give aminomethyl derivatives.

206 a coli K1 polysaccharide capsule, coupled by reductive amination to tetanus toxoid and purified recom

207 de to convert ketone-containing compounds by reductive amination to their corresponding primary amine

208 need for a comprehensive review on catalytic reductive aminations to discuss the potential catalysts

209 atization, including periodate oxidation and reductive amination, took only ~3 h and achieved high la

210 A reduction and intramolecular reductive amination transformed the intermediate disacch

211 e nitro group in 13 to an amine, followed by reductive amination under acidic conditions, arrives at

212 This work describes the combination of reductive amination using 3-amino-9-ethylcarbazole, with

213 ubstituted diazatrithiacrown ethers 17-19 by reductive amination using 8-hydroxyquinoline-2-carboxald

214 , G and A) nucleotides in DNA substrates, by reductive amination using a 5'-benzaldehyde oligonucleot

215 of chiral Bronsted acid-catalyzed asymmetric reductive amination using a silane as the hydride source

216 been synthesized by periodate oxidation and reductive amination using a variety of R-NH2 substituent

217 quently, in this review we discuss catalytic reductive aminations using molecular hydrogen and their

218 In particular, catalytic reductive aminations using molecular hydrogen are highly

219 some of the desired aminoimidazoles, a novel reductive amination utilizing a trityl-protected aminoim

220 isplayed scalability issues, and competitive reductive amination was a problem for certain substrate

221 Reductive amination was employed to attach each strand o

222 urthermore, the efficiency of this migrative reductive amination was highlighted in a one-step synthe

223 The amines formed via intracellular reductive amination were quantified by high performance

224 attractive and include enzymatic asymmetric reductive amination, which offers an efficient route to

225 four garlic organosulfur compounds (OSCs) by reductive amination with (13)C, D2-formaldehyde, and dev

226 y, two glycan samples to be compared undergo reductive amination with 2-aminobenzoic acid and 2-(13)[

227 ary strands and ICL formation using a double reductive amination with a variety of amines.

228 diate is converted to the final products via reductive amination with an appropriately functionalized

229 Initial N-alkylation via reductive amination with anthracene-9-carbaldehyde provi

230 folate analogues on a slightly larger scale, reductive amination with either N2-acetyl or N2-pivaloyl

231 side to the four-carbon aldehyde followed by reductive amination with ethylenediamine.

232 Reduction and a second reductive amination with formaldehyde yielded the corres

233 e treatment with aldehyde silane followed by reductive amination with heterobifunctional amine-poly(e

234 ndards (ISs) for absolute quantification via reductive amination with isotopic formaldehydes.

235 minopyrido[2,3-d]pyrimidine (8), followed by reductive amination with the appropriate benzaldehydes o

236 GRIL), where free glycans are derivatized by reductive amination with the differentially coded stable

237 scuss the active species in electrocatalytic reductive amination with the transformation of acetone a

238 NaIO4 oxidation of the third digitoxose and reductive amination with various R-NH2 substituents and

239 ction conditions were also applied to facile reductive aminations with anilines known to have little

240 We also demonstrate preparative scale reductive aminations with wild-type and Q240A variant bi