ライフサイエンスコーパス: reference compound

1 d approved drugs) with background compounds (reference compounds).

2 l space sampled by ligands with respect to a reference compound.

3 th cyclopropane to produce a six-member ring reference compound.

4 the SE of the corresponding six-member ring reference compound.

5 ith cyclopropane to form a six-membered ring reference compound.

6 using relative peak areas with cannabinol as reference compound.

7 relative retention times with cannabinol as reference compound.

8 high-affinity GABAA antagonist was used as a reference compound.

9 lective AR antagonist caffeine, taken as the reference compound.

10 lectivity for ALK2 over ALK5, surpassing the reference compound.

11 lines applied in two doses, with KIO(3) as a reference compound.

12 -yl)methyl)phenol (compound 1) was used as a reference compound.

13 pared with butylated hydroxytoluene (BHT) as reference compound.

14 -carboxamide) and the S = 0 [Fe(PaPy3)CO](+) reference compound.

15 that required for CA-4P, which was used as a reference compound.

16 in vivo in comparison to a (all amide bond) reference compound.

17 X, XII, and XIV using acetazolamide (AAZ) as reference compound.

18 -(AHX-DTPA-111In)NH2]exendin-4 was used as a reference compound.

19 mpound was confirmed by analysis of the pure reference compound.

20 to be at least 10-fold more potent than the reference compound.

21 comparable to that of letrozole chosen as a reference compound.

22 ty were calculated using alpha-tocopherol as reference compound.

23 he relative rate technique, with methanol as reference compound.

24 citrin (quercetin-3-O-rhamnoside), used as a reference compound.

25 alues of desirable low molecular weight (MW) reference compounds.

26 on cycloalkanes, cycloalkenes, and selected reference compounds.

27 ns the same characteristics as those the two reference compounds.

28 ms, and delivered expected IC(50) values for reference compounds.

29 orders of magnitude lower than the relevant reference compounds.

30 ations and experimental data for appropriate reference compounds.

31 yl chloroformate (FLEC), avoiding the use of reference compounds.

32 l shifts and by direct addition of authentic reference compounds.

33 chemical space compared to selected diverse reference compounds.

34 ed using (177)Lu-RM2 and (177)Lu-NeoBOMB1 as reference compounds.

35 ecause of the isomers and lack of sufficient reference compounds.

36 al barriers within the range of those of the reference compounds.

37 mixtures, which does not require the use of reference compounds.

38 morphologies similar to those induced by the reference compounds.

39 asymmetry factors (g(abs)) compared to their reference compounds.

40 rget activity as compared to three prominent reference compounds.

41 le nanohoops together with their single hoop reference compounds.

42 ely used alkenylboronates alongside relevant reference compounds.

43 nd their spectra were compared with those of reference compounds.

44 ely to be found in post-2008 clinical versus reference compounds.

45 theory (DFT) calculations and comparison to reference compounds.

46 clinical compound NP character versus their reference compounds.

47 uperconductor discovery with conditioning on reference compounds.

48 higher D(3)R binding selectivities than the reference compounds.

49 d linear combination analysis of known XANES reference compounds.

50 sed to monitor the concentrations of CPA and reference compounds.

51 polation of the loss kinetics of performance reference compounds.

52 using, e.g., the chlorinated derivatives as reference compounds.

53 mentally measured mass spectra from chemical reference compounds.

54 fects of ethanol extract of DP (EDP) and its reference compounds.

55 der spectrum of activity than numerous other reference compounds.

56 ng HRGC-O, in comparison with the respective reference compounds.

57 and IR analysis of the isolated cofactor and reference compounds.

58 igh delta selectivity, H-Dmt-Tic--Lys(Z)-OH (reference compound 1) is a useful starting point for the

59 to the conformationally constrained 4-7 and reference compounds 1-3 catalyzed by alpha-2,6- and alph

60 exhibited comparable binding affinity to the reference compound, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydr

61 re stable (DeltaE = -20.2 kcal/mol) isomeric reference compound 2,2-difluoropropane.

62 nformationally constrained 6 and 7 and their reference compounds 2 and 3 further supports the fact th

63 The reference compounds 2 and 6 showed nanomolar affinity to

64 tion conditions have been optimized using as reference compounds 2-, 3-, 4-, or 6-monosubstituted man

65 sitivity of (68)Ga-OPS202, compared with the reference compound, (68)Ga-DOTATOC (an sst receptor agon

66 Results: Reference compounds 6R-1 and 6S-1 were obtained after ac

67 e mere addition of a key moiety found in the reference compound 7 (ABT-239) elevated the series to hi

68 porfiromycin C(8) cyclized imine (6) and its reference compound, 7-N-(1'-aminocyclohex-2'-yl)porfirom

69 ve are ca. 10 000 times more potent than the reference compound acyclovir and ca. 100 times more pote

70 ld enhancement in anti-VZV activity over the reference compound acyclovir, with no detectable in vitr

71 times and IR spectra with those of suitable reference compounds allows us to identify their specific

72 mutants analogous to those achieved with the reference compound ambroxol were attained with a more fa

73 t can be calculated after integration of the reference compound, analyte, and HDO signals using the g

74 comparable to what could be achieved by the reference compound and current clinical candidate TPCS(2

75 -Gly(11)-His(12)-Sta(13)-Leu(14)-NH(2)) as a reference compound and investigated [(68)Ga]Ga-AMTG in a

76 cterized in biological data sets to those of reference compounds and (ii) putative identification fro

77 ved from 42 Deltam features from 14 in-house reference compounds and a global set of 11 477 Deltam fe

78 by Pb L3-edge XANES measurements using solid reference compounds and also aqueous solutions of differ

79 ignatures is often hampered by a shortage of reference compounds and corresponding reference spectra.

80 tical comparison with chemically synthesized reference compounds and electrospray ionization-mass spe

81 Maximal recoveries of reference compounds and minimal interference from the ma

82 Reference compounds and precursors were synthesized foll

83 NMR-active nuclei, using both user-selected reference compounds and/or linear regression methods.

84 equilibrium conditions and using performance reference compounds) and calculating.

85 switches between the analyte and a standard reference compound, and leads to gaps in the analyte dat

86 d 24 demonstrated a greater potency than the reference compound, and molecular docking revealed stron

87 10 AR transactivation assays, 72 ER-binding reference compounds, and the in vivo uterotrophic assay.

88 57 strong activators (greater activity than reference compound apigenin), most of which were unrelat

89 spectroscopy, chemical shift assignments of reference compounds are required.

90 l ligands--one of the analyte and two of the reference compound) are collisionally activated, and the

91 c and antiaromatic (rather than nonaromatic) reference compounds, as calculated with a high-level met

92 exhibit higher antioxidant activity than the reference compounds ascorbic acid and TROLOX.

93 ) values (0.20-0.22 mg/mL) comparable to the reference compound; ascorbic acid (0.20 mg/mL).

94 oAs, phenomic profiles accurately ranked the reference compounds (AUC-ROC >= 0.9).

95 these compounds and, by comparison with the reference compound BaMn2Bi2, we show that the Dirac carr

96 termined in vitro intrinsic clearance of six reference compounds (benzo[a]pyrene, 4-nonylphenol, di-t

97 nists compared with their methyl-substituted reference compounds both in vitro and in plants.

98 g), FG 2 DMSO/saline (0.4 and 8 mg/kg) and a reference compound, BTZ043, DMSO/saline (0.4 and 8 mg/kg

99 re comparable to the ones determined for the reference compound butylhydroxytoluene.

100 been estimated relative to six-membered ring reference compounds by dimerization of dioxirane and or

101 l diffusivities of the two chemically stable reference compounds, caffeine and testosterone, were (1-

102 ntal MS/MS spectra for over a half a million reference compounds, chemical structures still cannot be

103 establish a spectral library of molecular Ti reference compounds, comprising various coordination env

104 fragment ions and neutral losses to related reference compounds contained in METLIN, even if the pre

105 d uptake one- to eight-fold greater than the reference compound CP04 at 1, 24, and 48 h.

106 ification of fibrosis demonstrated that both reference compounds decreased the deposition of fibrilla

107 environmentally relevant mineral and organic reference compounds demonstrated similar spectral qualit

108 s analog may be chosen as NMR chemical shift reference compounds depending on the nature of the biomo

109 Peak identification with reference compounds did not reveal specific marker compo

110 ectra of soil samples, along with a range of reference compounds differing in V-oxidation state and c

111 xidine, dinapsoline, and dinoxyline) and the reference compounds dopamine and quinpirole.

112 f the caffeinyl core and substituents of the reference compound (E)-8-(3-chlorostyryl)caffeine led to

113 Despite the lack of reference compounds, ECD of five oligomers ranging from

114 idation at doses 10-100 times lower than the reference compounds (either alone or in combination).

115 ing study was carried out on the analogs and reference compound (Erlotinib) into the ATP binding site

116 Since the emission from the reference compound Fluor-Et (the ethyl ester of fluoresc

117 The relative potency of C47 to the reference compound flutamide was over 5.2, whereas the d

118 Acetic acid (AA) was selected as a reference compound for complete oxidation and compared o

119 It is well studied as reference compound for H3R in rodent models for neurolog

120 Using the second emitter to introduce a reference compound for internal calibration, accurate ma

121 tinib, an FDA-approved anticancer drug, as a reference compound for molecular docking with MAPK14.

122 Spectral resolution allows the use of reference compounds for accurate quantification of conce

123 roteolytic fragments provide a useful set of reference compounds for analysis of the LPO(N) and LPO(C

124 (III) and Ru(III) analogues were prepared as reference compounds for assessing the effect of the 5d v

125 ing benzhydrylium ions, which can be used as reference compounds for characterizing a wide variety of

126 e developed as a new group of nonradioactive reference compounds for future radiotracers.

127 Even if reference compounds for the active drugs are readily obt

128 diaminoquinazoline analog) was the only non-reference compound found to inhibit the growth of all fo

129 gonist activity in the T47D assay, while the reference compounds from other related nonsteroidal hPR

130 e (37) show improved potency compared to the reference compound FUT-175.

131 displaying a lower potency in vitro than the reference compound GS39783, the new compounds 6, 10, and

132 For comparison, the reference compound GYKI 52466 (2) had an IC50 of 6.9 mic

133 of the mass difference (DeltaM) from a known reference compound has been greatly successful in the re

134 ilane was recommended for use as an internal reference compound in proton NMR spectroscopy over 60 ye

135 Competition kinetics with phenylalanine as a reference compound in pulse radiolysis experiments yield

136 Transformation products of the reference compounds in activated sludge samples were con

137 ladders have been constructed of appropriate reference compounds in dichloromethane and in acetonitri

138 of five caged crown ethers and two polyether reference compounds in methanol solution.

139 A total of 560 reference compounds, including 8 odd n-alkanes, were ana

140 s-glutathione conjugate and a monofunctional reference compound indicates that the bivalent inhibitor

141 the retention index (I) calculation without reference compound injection was established.

142 Infusion of a reference compound into one inlet provides a single-poin

143 The choice of the reference compound is especially important for geminal e

144 The concept of mass difference from a reference compound is introduced to simplify the approac

145 igands-2 mol of the analyte and 1 mol of the reference compound) is collisionally activated and under

146 simultaneously and separately in relation to reference compounds it is possible to make quantitative

147 On the basis of the availability of these reference compounds, it was shown that the metabolic hyd

148 ol, norepinephrine, propranolol) with chiral reference compounds (L-amino acids) are generated by ele

149 spectively, relative to a similar silicon pc reference compound lacking the TTF moieties.

150 Compounds were identified based on reference compounds, linear retention indices, odor desc

151 parable or superior to the clinically tested reference compound [Lys40-(AHX-DTPA-111In)NH2]exendin-4

152 Methods: Reference compound Me-NB1 (inhibition constant for hGluN

153 cting mu opioid receptor antagonist, and the reference compound methylnaltrexone, upon POI were inves

154 urements confirmed the results obtained from reference compounds, model samples, and real-world speci

155 of one or more of the three BisPEBs and the reference compound MPEP.

156 tumor uptake in comparison to the all-amide reference compound [Nle(15)]MG11.

157 tion and identification by using enantiopure reference compounds of eleven racemic TAGs with C12-C22

158 Our approach does not require reference compounds or large databases of experimental d

159 The performance and reference compound (PRC) approach would be then applicab

160 The release of performance reference compounds (PRC) dosed to passive samplers prio

161 sed the dissipation rate of four performance reference compounds (PRCs) from passive samplers.

162 r dissolution and dissipation of performance reference compounds (PRCs) from silicone.

163 diffusive retardation factors as performance reference compounds (PRCs) that are diffusing out of the

164 strips that were preloaded with performance reference compounds (PRCs) were codeployed for 32 d alon

165 Performance reference compounds (PRCs) were used with PE and POM to

166 ers of the amino groups compared to those of reference compounds presenting a single pai-system (11-1

167 The nonradioactive reference compound PSMA-1007 and the precursor were prod

168 Methods: The nonradioactive reference compound PSMA-1007 and the precursor were prod

169 man cardiomyocytes with validation utilizing reference compounds recommended for the evolving Compreh

170 e in which a chiral analyte (A) and a chiral reference compound (ref*) are simultaneously coordinated

171 n branching ratios measured when pure chiral reference compounds (ref*D and ref*L) are employed in se

172 re triglycerides than those treated with the reference compound rosiglitazone.

173 al HIF1 stable bioassay toward detecting the reference compound roxadustat was 100 nM, increasing to

174 Such findings were absent with the added reference compound sitostanol.

175 an, rat, and mouse, which were "spiked" with reference compound solutions at known concentrations.

176 best-fit transformations between signals in reference compound spectra and the corresponding signals

177 lecular engineering at terminal acceptors of reference compound (SPFR).

178 nce is typically calibrated by addition of a reference compound such as 3-(trimethylsilyl)-propionic

179 rposeful inclusion of cytotoxic and nuisance reference compounds such as those profiled in this resou

180 chemical and biological properties of these reference compounds suggest many could be used to interr

181 minutes) was >7-fold slower than the slowest reference compound tested, AZD-1981.

182 This is made possible by the use of a reference compound that ionizes to a similar extent in b

183 demonstrated through direct comparison with reference compounds that the presence of a fluorine atom

184 Compared to Trolox, a commonly used reference compound, their radical scavenging capacities

185 pure sample of yuzunone, which was used as a reference compound to check its presence by GC-MS and GC

186 Bromocriptine was used as a reference compound to compare the results obtained with

187 -phenyl-3H-isoindol-1-one, was included as a reference compound to confirm the impact of the selenium

188 rate constants relative to diclofenac, as a reference compound, to account for the difference in the

189 ral databases as well as a lack of available reference compounds, two common analytical limitations r

190 RIEs were normalized against one reference compound used across all methods to ensure com

191 The data clearly demonstrate that the reference compounds used to estimate the SE for highly s

192 rolyte compositions, comparable to a neutral reference compound, (v) the protonated weak base was str

193 cine and otonecine-type PAs by comparison to reference compounds via a spectral library.

194 For each series, a monofunctional reference compound was also prepared to determine the re

195 The precursor for radiolabeling and reference compounds was synthesized in up to five steps

196 LRI for all 552 reference compounds were also calculated based upon comp

197 aid in the identification, while a set of 51 reference compounds were analyzed simultaneously for tar

198 polyethylene (LDPE) loaded with performance reference compounds were applied independently to measur

199 These reference compounds were randomly split into training (n

200 onotropic as well as QT-prolongation causing reference compounds were used for validating the cardio

201 of pyrene and deuterated pyrene (performance reference compound) were within 0.1 log unit for all exp

202 known experimental log Ko/w values served as reference compounds, whereas the PCB compounds without k

203 taDeltalogR) were calculated relative to the reference compound WIN55,212-2 for Galphai/o, Galphas, G

204 ASH hLiMTs was validated using anti-fibrotic reference compounds with different therapeutic modalitie

205 antagonists was evaluated using a set of 39 reference compounds with known ERalpha activity.

206 The combined method characterized 7 reference compounds with previously reported anticancer/

207 he correlation of the log Kp/s values of the reference compounds with their log Ko/w values.

208 (R)-2 was more efficient than (R)-1 and the reference compounds, with some exceptions.

209 structures to be solved in complex with the reference compound ZM241385 and four related ligands at