ライフサイエンスコーパス: refine

1 many of which are still to be discovered or refined.

2 Comparison of refined 3D geologic models of the lobes with triaxial el

3 plexed FISH imaging offers possibilities for refined 3D reconstruction accuracy evaluation, availabil

4 y 1, 2018, and June 25, 2018, we iteratively refined a culturally targeted video for AAs with input f

5 In this study, we refined a previously identified 111-gene outcome predict

6 ssing includes a melanging step, a chocolate refining (a process involving time and temperature to re

7 atty acids are not interdependent after mild refining activities.

8 ed in this study should be investigated in a refined algorithm combining the quantitative FIT result.

9 The refined algorithm generates proteins that remain folded

10 This work will aid development of refined AMPAR epilepsy therapeutics and facilitate to un

11 Here we refine an enrichment culture that exhibits exponential g

12 alth of information that can be learned from refined analysis of medical image segmentations.

13 oved reconstruction of plasmid sequences and refined analysis of metagenomic data to read error corre

14 Our findings refine and add nuance to our genomic definitions of epid

15 presents an evolving construct that has been refined and developed over the past several decades in r

16 This result indicates that oleogels made by refined and EP corn germ oil together with RBX have the

17 Overall, RBX could form oleogels in both refined and EP corn germ oils at a concentration >=3 wt%

18 Finally, we refined and functionally validated the sorting strategy

19 ich may fast-forward the development of more-refined and less-toxic treatments.

20 nogenicity and protective efficacy (PE) of a refined and more stable chimera comprised of a pentameri

21 bioprinting technology that have become more refined and specialized over the years, and stem cells a

22 pasta products have been developed based on refined and wholegrain wheat and spelt flours.

23 Mechanotransduction refines and maintains row identity, thus instructing the

24 titutional efforts should be directed toward refining and personalizing prescribing recommendations.

25 Nature evolves materials discovery by refining and transmitting the blueprints using DNA mutat

26 Here, we present DRAM (Distilled and Refined Annotation of Metabolism), a framework to transl

27 These findings can refine Arabidopsis genome annotation.

28 ng our torsion angles refinement method OPUS-Refine as the post-processing procedure for OPUS-TASS, t

29 wall metabolism, which will only become more refined as emerging technology allows us to tackle the r

30 cknowledging that the classification will be refined as new data are generated.

31 We demonstrate that CNN-based analyses can refine association signals at T2D-associated loci and pr

32 esents a promising non-invasive approach for refined atherosclerotic risk prediction.

33 urgent need for robust methods to create and refine atomic-level structural models using low-resoluti

34 The guidance document will thus be refined based on iterative and comprehensive monitoring

35 ) databases and displays results that can be refined based on user interactions.

36 isease, offering convergent evidence to help refine Bastin et al.'s integrative memory model.

37 efore, we sought to test the hypothesis that refined blood transcriptional biomarkers of active tuber

38 still needs to be accomplished, not only to refine but also to build support for the application and

39 Finally, the network is further refined by being trained with the experimental data.

40 Unique to this work, the far-field model is refined by contrasting the experimental dispersion and d

41 Saqunda was short-lived and was subsequently refined by introducing additional fluxing agents.

42 ge fields, whose spatial representations are refined by sensory experience to signal areas of behavio

43 s of reliance on inflammatory signals, and a refined capacity of NK cells to target malaria parasites

44 cement of SFAs with unsaturated fat, but not refined carbohydrate and added sugars, is associated wit

45 ch cohort taking into account consumption of refined carbohydrates (starches and sugars).

46 g myopia (defined as < 0 D) and frequency of refined carbohydrates consumption adjusted for risk fact

47 Refined carbohydrates consumption could be associated wi

48 The consumption of refined carbohydrates significantly increased the probab

49 ence to diets consisting of a high intake of refined carbohydrates, sugars, and salty foods in the fr

50 time, physical activity, and consumption of refined carbohydrates.

51 viously reported kinetics data, we propose a refined catalytic mechanism for Chd-mediated TPN dehalog

52 and nuts and decreasing their consumption of refined cereals, added sugars, and sugar-sweetened bever

53 The refined chimera, dsc(14)CfaE-sCTA2/LTB, was highly immun

54 This specific pattern could help to refine clinical and electrophysiological ALS diagnostic

55 ed homogeneity assumption limits progress in refining clinical diagnosis, understanding mechanisms, a

56 Our study demonstrates that refined computational docking and simulation studies com

57 Refined corn oil produced a stronger gel than crude corn

58 utionarily acquired miRNA in eutherians that refines cortical projection neuron subtype development.

59 These findings can contribute to refining cost-effective mitigation strategies based on f

60 ilance, longitudinal local surveillance, and refined criteria to identify patients requiring therapy

61 Further research should focus on refining criteria for the use of extracorporeal membrane

62 The crystallographically refined crystal structures using single-crystal X-ray di

63 onal activity may play a cooperative role in refining CS axonal projections.

64 hronic angle closure and may be relevant for refining current definitions and management of PACD.

65 d cluster of PIM with exceeding BTMs, a more refined definition of peri-implant conditions according

66 We present Avant-garde as a tool to refine DIA (and parallel reaction monitoring) data.

67 We recorded all patient refined diagnostic related groups codes, blood pressure,

68 More refined disorder-specific analyses suggested that these

69 l type-specific treatment strategies require refined dissection of the entire progression at the cell

70 behaviours, or which aspects take longer to refine during the maturation process.

71 e generated at candidate nomination and then refined during clinical development.

72 t in a goal-directed manner is progressively refined during development, but this refinement can be i

73 We refined each QTL by combining information inferred from

74 nition, perhaps providing another target for refining early identification and intervention strategie

75 Future research should refine estimates of the effects of coverage expansion on

76 artly calcified braincase, which potentially refines estimates of its prenatal stage.

77 indings further highlight the need of a more refined, ethnic-specific normative database for GCIPL th

78 ining genes of other blow flies will allow a refined evolutionary understanding of how flies with a t

79 We advocate refining existing measures and developing new metrics th

80 m sensing inhibition effects of "430D-F5", a refined extract derived from the fruits of Schinus tereb

81 nd increased adhesiveness when compared with refined flours.

82 is susceptible to over-detection and must be refined for robust, reproducible detection in a wide ran

83 The output can be further refined for the measurement of cluster area, shape, and

84 It is a refined framework of comparing two toehold exchange reac

85 this barrier, we demonstrate a strategy for refined genetic manipulation of vitamin status based on

86 ubstantial disease heritability and can help refine genome-wide association signals.

87 y play essential role in gene regulation and refine global polymeric folding of the chromatin fiber.

88 association was observed for intake of total refined grain.

89 higher modified DQIS subcomponent scores for refined grains and protein, indicating higher age-approp

90 f dietary added sugars, starch, and nonwhole/refined grains were each associated with higher odds of

91 ns with BC risk for intakes of whole grains, refined grains, and dietary fiber.

92 : meats and high-fats; prudent diets; sugar, refined grains, and processed foods; and traditional veg

93 ate-containing foods (whole grains, nonwhole/refined grains, nonjuice fruits, vegetables, dairy produ

94 wer consumption of less-healthy plant foods (refined grains, potatoes, sugar-sweetened beverages, swe

95 cts, fish and nuts, and lower consumption of refined grains, red and processed meat, sugar-sweetened

96 =4 servings/wk of green leafy vegetables and refined grains.

97 nucleotide polymorphisms (SNPs) enabling the refined grouping of the sampled tea accessions into five

98 er period in which the behavior becomes more refined, habitual, and automatized.

99 are perceptual experts and we are constantly refining how we detect and discriminate objects in the w

100 ances in genetic analyses have significantly refined human type 1 diabetes (T1D) associated loci.

101 prkdc(-/-), il2rgalpha(-/-) model, including refined husbandry protocols for optimal growth and reari

102 rotein structure modeling, we have assembled refined I-band and H-zone models with unparalleled scope

103 >=7 cM IBD segments at quality comparable to Refined IBD and GERMLINE.

104 gle 5 takes 4.3 CPU days, followed by either Refined IBD or GERMLINE segment detection in 2.9 or 1.1

105 ve sweeps can consequently help identify and refine important loci linked to domestication.

106 lity of high-throughput experimental data to refine in silico hiPSC-CM populations and to predict and

107 on achieved at the first step can be further refined in a second step, if necessary.

108 the AL is initially pre-patterned and later refined in an OSN-dependent manner.

109 We test its performance using: structures refined in explicit solvent, which are much better than

110 stream segregation that emerges in A1 and is refined in PEG.SIGNIFICANCE STATEMENT To interact with t

111 cess, present in primary auditory cortex and refined in secondary auditory cortex, in which sound rep

112 and feedback as key adaptive mechanisms for refining individual and collective judgments.

113 n cell fate decision will likely rely on the refined integration of experiments, large-scale omics da

114 In addition, the use of i-OCT refines intraoperative steps, thereby optimizing the pos

115 Using MapBiomas 3.1 and recently refined IPCC carbon sequestration estimates, we mapped t

116 padding and raises awareness of the need to refine it for better performance.

117 s a real challenge: how does one distill and refine it into images while retaining its significant co

118 urobiology of ASD and sleep each become more refined, it is conceivable that sleep-derived metrics ma

119 ral practice, cold storage, puree mechanical refining level) and (ii) establish the link between qual

120 As examining the human genome at more refined levels increases, so is the likelihood of encoun

121 We discuss how advancing technologies have refined lineage-tracing studies, and how clonal analysis

122 on of twilights, calibration, estimating and refining locations, and extraction of movement patterns

123 A refined locus for adRP on Chr17q22 (RP17) was delineated

124 The process does not form the typical refining markers, e.g. stigmastadienes, and 2.

125 spholipids (PL) in tissue sections by use of refined matrix-assisted laser desorption ionization mass

126 ese results collectively provide a unifying, refined mechanism of RDV-mediated RNA synthesis inhibiti

127 rror approach to treatment, moving to a more refined method that augurs a new era for patients and cl

128 rates are low or extremely low and recommend refining methods to include potential holds for accurate

129 ition research emerged from the workshop: 1) refining methods to measure chemosensation in large coho

130 ds (SCFAs) was tested as a more targeted and refined microbiome therapy.

131 s, we extend previous findings and propose a refined model in which RIM and Munc13-1 act in overlappi

132 ve human neutrophil progenitor and propose a refined model of the neutrophil developmental lineage in

133 A refined model using Monte Carlo parameter sampling was u

134 ntal observations, suggesting the need for a refined model.

135 ters within routine surveillance could allow refined monitoring of local subepidemics.

136 tegration in the cerebellum is essential for refining motor output, and the first stage of this proce

137 dy pitch and roll, may enable researchers to refine movement-based metabolic costs, particularly in a

138 e signals of shared ancestry to identify and refine multiple putative regulatory elements in Heliconi

139 uronal activity regulate axon elimination to refine neuronal circuits during development.

140 ers host and pathogen proteins to perform or refine new functions have been explored only recently.

141 patterns that are crucial for the wiring and refining of developing sensory circuits.

142 non-targeted approach will contribute to the refining of food safety risk assessments.

143 ying the activity of thousands of guides, we refine on-target design rules and develop a comprehensiv

144 ression and, if prospectively validated, may refine OPSCC patient selection for risk-adaptive therapy

145 ts diagnosed with invasive breast cancer and refined OS estimates.

146 s to deconvolute our experimental CD data to refine our computational model of the peptide secondary

147 Collectively, these findings refine our current understanding of continental migratio

148 To revise and refine our estimation of future flood risk, this work hi

149 mour biology and immunology that continue to refine our understanding of cancer, therapies are now be

150 e of haplotype-aware variant annotation, and refine our understanding of genome-wide mutational mecha

151 Our results refine our understanding of Neanderthal ancestry in Afri

152 netic patterns of defense production and can refine our understanding of plant-herbivore interactions

153 l model can be used to further challenge and refine our understanding of the system's activity and gu

154 ography and electron microscopy studies have refined our model of herpesvirus entry into cells, clari

155 This work refines our understanding of the role of iron sulfide mi

156 Emerging techniques are refining our ability to decipher otherwise cryptic human

157 ew tools and discoveries are challenging and refining our definitions of a cell type.

158 Refining our knowledge of the direct and indirect impact

159 Reconstitution enabled genetic experiments refining our understanding of the CCM, thereby laying th

160 We refined ovarian stimulation and in vitro fertilization (

161 oviding rigorous confidence intervals on the refined parameters.

162 ly associated with inducible VT and may help refine patient selection for programmed VT-stimulation w

163 thermore, provides an alternative pathway to refine PC output.SIGNIFICANCE STATEMENT The brain can ad

164 Larger samples sizes, refined phenotypes and higher-resolution genome-screens

165 d transcriptome, and new approaches to study refined phenotypes for a greater appreciation of the dev

166 addition, the proposed scheme incorporates a refined physics model that considers the Coulomb-laser c

167 closely related to animals will allow a more refined picture of how the last common ancestor of anima

168 Our results suggest a refined picture of the platelet signal transduction netw

169 ropose an actor-critic learning algorithm to refine policy parameters and obtain a policy that can be

170 riety of possible poses, and then scores the refined poses.

171 art, and lung patients helped to develop and refine potential displays of center outcomes and underst

172 Besides, refined PPMO contains remarkably greater concentrations

173 Results showed that refined PPMO has comparable physicochemical properties a

174 ester and trace metals) analyses proven that refined PPMO is safe to be consumed.

175 The overall quality assessment of refined PPMO showed that it is suitable for human consum

176 ions, providing an opportunity to assess and refine prediction methods.

177 ve responded to past climate change may help refine projections of how species and biotic communities

178 Our results suggest the need to refine PSB and crack-initiation models in metals to acco

179 etics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances

180 re held in June, 2019, and January, 2020, to refine recommendations.

181 re limited, therefore, quality assessment of refined red palm-pressed mesocarp olein (PPMO) is deemed

182 ng offers a perspective for a future of more refined redox medicine.

183 reporting of clinical research data and for refining reimbursement guidelines.

184 en target sequence and licking rather than a refined representation of sensory features.

185 ent a feature representation approach termed REFINED (REpresentation of Features as Images with NEigh

186 Interactive steps were implemented to refine results.

187 ice deficient in C1q, which fail to properly refine retinogeniculate connections, have elevated presy

188 monitoring of treatment response, capable of refining retrospective, tissue-based analysis, are still

189 SA estimated by this model could be used to refine risk estimation and optimize the use of imaging f

190 tion, multiple biomarkers have been shown to refine risk stratification and can be considered for sel

191 programs, guiding therapeutic interventions, refining risk for families at high risk, and facilitatin

192 owing several rounds of debate; and third, a refined search to target debated or rapidly updating iss

193 tients with early-stage colorectal cancer to refine selection of adjuvant therapy.

194 DK inhibitors in living cells, and present a refined set of tool molecules to study CDK function.

195 Two refined signatures of four and two antibodies were capab

196 Two refined signatures were identified using stepwise logist

197 Two refined signatures with either four (LF2 and BGLF2 IgG,

198 to assess the ability of Meltos to correctly refine SNV trees with SV information, we tested Meltos o

199 The subsequent refining steps recover the clovamide concentration.

200 reater mechanistic understanding in order to refine strategies for therapeutic discovery and developm

201 Further research is needed to refine strategies that may perhaps improve survival if m

202 , and to improve long-term patient outcomes, refined strategies for the monitoring of patients after

203 The refined strategy resulting from iterative improvements t

204 The refined structure revealed unmodeled densities between p

205 the top solutions are outputted as the final refined structures.

206 r pregnant women enrolled in the SUSTAIN and REFINE studies between Jan 1 and May 30, 2020, from nine

207 state of the tissue are urgently needed for refined studies of the underlying mechanisms.

208 bility across cells and species, possibly by refining sub-TAD-scale loop contacts responsible for cel

209 -human comparative findings that should help refine such analyses.

210 n should be paid to sustained investments in refined supply of Co and secondary recovery.

211 Increasingly refined syn-BNP-based explorations of biosynthetic gene

212 stimulation parameter selection, as well as refine targets for neuromodulation therapies for Tourett

213 It is therefore a more refined technique for DNA collection with the potential

214 (a process involving time and temperature to refine texture and flavor) process that occurs in a ston

215 ty of a genetic predictor that might further refine the assessment and management of atherosclerotic

216 by employing novel methodological tools that refine the biological systems we target.

217 We refine the boundaries of an area of ~0.35 km(2) below th

218 esults uncover important health disparities, refine the concept of the allergic march, and represent

219 at were graded independently by attendees to refine the consensus definitions and descriptions furthe

220 of GATAs is modulated by their cofactors to refine the differentiation of neuronal subtypes.SIGNIFIC

221 ween aneuploidy, autophagy, and apoptosis to refine the embryonic cell population and ensure only chr

222 G cross-protection from severe COVID-19, and refine the epidemiological analysis to mitigate effects

223 These patterns should help to refine the establishment of the homology of DA nuclei be

224 fying newly discovered TA systems as well as refine the framework for recognizing the diverse biochem

225 as WT, as a control, we were able to further refine the HDX analysis, highlighting the regions of mAD

226 of peptides binding in HLA-DP may be used to refine the HLA-DP group classification.

227 trajectories of alphabeta T cell subsets and refine the kinetic selection model of CD4(+) and CD8(+)

228 rds for palliative care interventions and to refine the models to further improve access to quality p

229 shows that artificial intelligence can help refine the prediction of HCC prognosis.

230 molecular-based diagnosis, allowed to better refine the prescription of SLIT, based on specific sensi

231 History can help refine the resource-rational model by uncovering how cul

232 Some data needed to refine the selection of eyes for the cohort were not ava

233 Reported herein is our first attempt to refine the stereoselectivity of the cooperatively cataly

234 Network analysis techniques were employed to refine the thousands of potential outputs and elucidate

235 a Strategic and unique Method to Advance and Refine the Treatment (SMART) of CRC through hot and cold

236 across the many different models in order to refine the vast literature on self-regulation.

237 e have recently developed new components and refined the existing ones to keep up with the computatio

238 he structure at 1.6 angstrom resolution, and refined the model to R (work) and R (free) values of 17.

239 xtended peptide libraries, we identified and refined the peptide binding motifs for each of the four

240 We also refined the reconstruction of tumor evolution, timing al

241 We refined the structure of DDM and evaluated the activity

242 Then we refined the tE/I ratio to cell-type signatures in the mo

243 del B) the first tension-generating step and refined the two models by downhill simplex runs against

244 This new human enteroid culture methodology refines the ability to study microbiome:human intestinal

245 Next, a filtering step refines the data from all identified cell phenotypes to

246 The PRS also refines the risk assessment of women with first-degree r

247 This study refines the understanding of the integrated immune respo

248 vant settings, thereby further expanding and refining the clinical application of CDK4/6 inhibitors f

249 th common and rare genetic variants, thereby refining the epigenomic architecture of psychiatric diso

250 By refining the experimental culture medium and creating an

251 ence-based methods to apply new knowledge in refining the international harmonized recommendations de

252 in layer 2/3 by cellular exchange and not by refining the original circuit.

253 ations of the avoidance strategy and further refining the process of managing reactive metabolite iss

254 ome in patients with HFpEF; its use may help refining the routine risk stratification of these patien

255 ard that now allows designers to inspect and refine their designs with base-pair level interventions.

256 or the non-breeding season and progressively refine their migration route as they age.

257 e we describe a class of IspH inhibitors and refine their potency to nanomolar levels through structu

258 cy of 3-hydroxyflavone-based derivatives and refine their potential medical applications as photoCORM

259 ovement sequences and the effort required to refine them.

260 These findings indicate the necessity to refine therapeutic approaches that stimulate immune resp

261 schema for more precise prognostication and refined therapeutic approaches.

262 n be regulated may present an opportunity to refine therapeutics for the treatment of pain.

263 Future research should seek to refine these diagnostic frameworks and identify targeted

264 To extend and refine these findings, we examined changes in human CD4(

265 e COTS group members met in November 2018 to refine these statements by a 2-step modified Delphi proc

266 As we refine these tools and approaches, we will continue to p

267 Experiment 2a/b refined these observations by showing how isolated manip

268 Refining these models further, we show that the magnitud

269 Bioinformatics analysis was used to refine this list and the top seven microRNAs were valida

270 assessment of ~30% of these participants, we refined this set of markers from 343 to 28, based on the

271 aining every peptide in a proteome, and then refines those libraries with empirical data.

272 -day consensus meeting (31 stakeholders) and refined through a checklist pilot (34 participants).

273 in a consensus meeting (31 stakeholders) and refined through a checklist pilot (34 participants).

274 The enumerative algorithm was tested and refined through feedback from two rounds of large-scale

275 emission as a treatment target and should be refined through future research, patient input, and clin

276 Before this processing, olfactory input is refined through the feedback provided by amygdala cortic

277 using single-wavelength anomalous dispersion refined to 1.96 angstrom resolution.

278 if the contextual image of the tracks can be refined to a level comparable to that of the target, man

279 sm on FXR and PPARdelta and was structurally refined to a potent and balanced FXR/PPARdelta activator

280 provides a solid basis which can be further refined to concur with higher-throughput single cell gen

281 entify aspects of the protocol that could be refined to enhance accuracy.

282 on, gastric variceal classification has been refined to include inflow and outflow based hemodynamic

283 flexible nature means that our model can be refined to simulate specific systems and could have appl

284 ve olivocochlear efferent innervation, which refines tonotopic mapping, improves sound discrimination

285 -handed assessment of the potential value of refined tools of this sort cannot currently be made beca

286 , greater than expected homeostatic fitness, refined transcription factor dependencies, and a distinc

287 c biopsies of HT-resistant patients can help refine treatment approaches.

288 are, improve diagnostic acumen worldwide and refine treatment strategies, including with anti-VEGF ag

289 lace high confidence validated SV calls on a refined tumor phylogeny tree.

290 tribution in the cell, they cannot provide a refined understanding of signaling at distinct subcellul

291 ed as computational models, which can now be refined using recently available data from transgenic ma

292 magnetic resonance images may be helpful in refining VA risk in patients with ischemic cardiomyopath

293 Using a refined version of a previously described WDD-binding am

294 Here we present an updated and refined version of this approach, mCSM-AB2, capable of a

295 This new understanding has led to a refined view of how NF-kappaB and cell death signaling a

296 ronal subpopulations that promise to offer a refined view of the circuit mechanisms surrounding depre

297 By refining where and when these genes are required using d

298 as a first-line approach, followed by a more refined whole genome sequencing analysis.

299 tional topography of association networks is refined with age, allowing accurate prediction of unseen

300 e nuclear pore complex (NPC) continues to be refined with cryo-EM and x-ray crystallography, in vivo