ライフサイエンスコーパス: refined

1 over the past decade and will continue to be refined.

2 many of which are still to be discovered or refined.

3 Comparison of refined 3D geologic models of the lobes with triaxial el

4 plexed FISH imaging offers possibilities for refined 3D reconstruction accuracy evaluation, availabil

5 y 1, 2018, and June 25, 2018, we iteratively refined a culturally targeted video for AAs with input f

6 In this study, we refined a previously identified 111-gene outcome predict

7 view of positional information being slowly refined across successive layers of the patterning netwo

8 ed in this study should be investigated in a refined algorithm combining the quantitative FIT result.

9 The refined algorithm generates proteins that remain folded

10 This work will aid development of refined AMPAR epilepsy therapeutics and facilitate to un

11 was prognostic for overall survival (OS) and refined an established 17-gene stemness score.

12 cell quiescence and techniques enabling more refined analyses of quiescence in vivo.

13 alth of information that can be learned from refined analysis of medical image segmentations.

14 oved reconstruction of plasmid sequences and refined analysis of metagenomic data to read error corre

15 presents an evolving construct that has been refined and developed over the past several decades in r

16 This result indicates that oleogels made by refined and EP corn germ oil together with RBX have the

17 Overall, RBX could form oleogels in both refined and EP corn germ oils at a concentration >=3 wt%

18 Finally, we refined and functionally validated the sorting strategy

19 lecular interactions consideration have been refined and implications for rational drug design with h

20 erforming models, sMtb2018 and iEK1011, were refined and improved for use in future studies by the TB

21 ich may fast-forward the development of more-refined and less-toxic treatments.

22 nogenicity and protective efficacy (PE) of a refined and more stable chimera comprised of a pentameri

23 bioprinting technology that have become more refined and specialized over the years, and stem cells a

24 pasta products have been developed based on refined and wholegrain wheat and spelt flours.

25 Disease associations have been refined, and interactions of HLA genotype with other gen

26 Here, we present DRAM (Distilled and Refined Annotation of Metabolism), a framework to transl

27 Importantly, a more refined appreciation of the intramolecular mechanisms re

28 The construction of refined architectures plays a crucial role in performanc

29 wall metabolism, which will only become more refined as emerging technology allows us to tackle the r

30 lable experimental data, and is continuously refined as more data is gathered.

31 cknowledging that the classification will be refined as new data are generated.

32 esents a promising non-invasive approach for refined atherosclerotic risk prediction.

33 ), and SrTiO(3) were well modelled using the refined average structural models: trigonal R[Formula: s

34 The guidance document will thus be refined based on iterative and comprehensive monitoring

35 recommendations, however, need to be further refined based on more systematic data.

36 ) databases and displays results that can be refined based on user interactions.

37 efore, we sought to test the hypothesis that refined blood transcriptional biomarkers of active tuber

38 ffraction data using simulated annealing and refined by a least-squares Rietveld refinement procedure

39 lian grape pomace distillate grappa is often refined by ageing in wooden barrels.

40 Finally, the network is further refined by being trained with the experimental data.

41 Unique to this work, the far-field model is refined by contrasting the experimental dispersion and d

42 opment is instructed by genetic programs and refined by distinct mechanisms that couple neural activi

43 The model iSR929 was refined by integrating RNAseq data of S. marcescens grow

44 Saqunda was short-lived and was subsequently refined by introducing additional fluxing agents.

45 el data-driven scoring strategy: signals are refined by learning from the dataset itself, using all m

46 on are inferred by genetic algorithm and are refined by local search.

47 ge fields, whose spatial representations are refined by sensory experience to signal areas of behavio

48 Antibodies are created and refined by somatic evolution in B cell populations, whic

49 capabilities of in silico prediction tools, refined by the use of RT and CCS prediction, to prioriti

50 s of reliance on inflammatory signals, and a refined capacity of NK cells to target malaria parasites

51 cement of SFAs with unsaturated fat, but not refined carbohydrate and added sugars, is associated wit

52 gy); 0.86 (0.82-0.91; P<0.001) for replacing refined carbohydrates (5% energy); 0.91 (0.85-0.97; P<0.

53 ch cohort taking into account consumption of refined carbohydrates (starches and sugars).

54 g myopia (defined as < 0 D) and frequency of refined carbohydrates consumption adjusted for risk fact

55 Refined carbohydrates consumption could be associated wi

56 However, any influence that refined carbohydrates have on risk of insomnia is likely

57 The consumption of refined carbohydrates significantly increased the probab

58 Replacement with other animal fats or refined carbohydrates was associated with higher risk.

59 unhealthy foods (saturated fats, trans fats, refined carbohydrates, excessive salt, and alcohol), pro

60 isk was observed when saturated fatty acids, refined carbohydrates, or trans fats were replaced by MU

61 ence to diets consisting of a high intake of refined carbohydrates, sugars, and salty foods in the fr

62 time, physical activity, and consumption of refined carbohydrates.

63 and lower their intakes of both calories and refined carbohydrates.

64 viously reported kinetics data, we propose a refined catalytic mechanism for Chd-mediated TPN dehalog

65 n benefits from precise visual orienting and refined categorisation criteria.

66 and nuts and decreasing their consumption of refined cereals, added sugars, and sugar-sweetened bever

67 disulfide bonds and interactions via ions, a refined characterization of entanglement in terms of kno

68 We propose a refined 'Chemokine Cloud' model, arguing that chemokines

69 The refined chimera, dsc(14)CfaE-sCTA2/LTB, was highly immun

70 uire multiple lines of evidence along with a refined chronology.

71 In analogy we refined CMAP and MUNE methods for assessing spinal MU in

72 Increased refined coal use, which may be treated with bromide, con

73 Our study demonstrates that refined computational docking and simulation studies com

74 Refined corn oil produced a stronger gel than crude corn

75 omes from environmental samples have further refined, corrected and revolutionized understanding of t

76 ples that would require Gsp sensing, such as refined cottonseed oil, palmitic acid, linoleic acid, an

77 ilance, longitudinal local surveillance, and refined criteria to identify patients requiring therapy

78 The crystallographically refined crystal structures using single-crystal X-ray di

79 We have refined crystallization conditions for KRAS(169) (Q61H)-

80 Taken together, the approaches and refined datasets in this work will greatly enable future

81 The 2016 ISGPS refined definition of B-POPF is predicated on various po

82 d cluster of PIM with exceeding BTMs, a more refined definition of peri-implant conditions according

83 gene expression datasets have allowed for a refined definition of the gene signatures that character

84 essed how the methylation profile altered or refined diagnosis in routine clinical practice and estim

85 We recorded all patient refined diagnostic related groups codes, blood pressure,

86 ate on different time scales and allow for a refined differentiation of the timing and mechanism of f

87 More refined disorder-specific analyses suggested that these

88 l type-specific treatment strategies require refined dissection of the entire progression at the cell

89 hydrolase-1, offers a new approach to a more refined dopaminergic therapy where l-DOPA is delivered c

90 Using a refined Drosophila model of mechanical nociception, we d

91 e generated at candidate nomination and then refined during clinical development.

92 t in a goal-directed manner is progressively refined during development, but this refinement can be i

93 gesting that topographic representations are refined during early development.

94 As training labels are refined during the process, the method is well suited to

95 We refined each QTL by combining information inferred from

96 se two parts was performed in humans using a refined electrophysiological method involving transcrani

97 indings further highlight the need of a more refined, ethnic-specific normative database for GCIPL th

98 ining genes of other blow flies will allow a refined evolutionary understanding of how flies with a t

99 e used in situations in which obtaining more refined experimental data is impractical.

100 m sensing inhibition effects of "430D-F5", a refined extract derived from the fruits of Schinus tereb

101 rdeum interesting also for the production of refined flours rich in bioactive compounds.

102 nd increased adhesiveness when compared with refined flours.

103 is susceptible to over-detection and must be refined for robust, reproducible detection in a wide ran

104 The output can be further refined for the measurement of cluster area, shape, and

105 It is a refined framework of comparing two toehold exchange reac

106 We find more refined frequency tuning in blind subjects, providing so

107 nanoparticles, the grains were significantly refined from coarse dendrites of hundreds of micrometers

108 this barrier, we demonstrate a strategy for refined genetic manipulation of vitamin status based on

109 We present a model, based on increasingly refined geometric parameters, that accurately predicts t

110 association was observed for intake of total refined grain.

111 and vegetables, compared with a diet high in refined grains and added sugars on inflammation and ener

112 higher modified DQIS subcomponent scores for refined grains and protein, indicating higher age-approp

113 sh, and vegetable oils and lower in meat and refined grains are associated with reduced risk of HDP,

114 r sources of animal fat or carbohydrate from refined grains was associated with a 17% (HR: 1.17; 95%

115 f dietary added sugars, starch, and nonwhole/refined grains were each associated with higher odds of

116 oultry, plant protein foods, oils, whole and refined grains, and added sugars.

117 ns with BC risk for intakes of whole grains, refined grains, and dietary fiber.

118 : meats and high-fats; prudent diets; sugar, refined grains, and processed foods; and traditional veg

119 ate-containing foods (whole grains, nonwhole/refined grains, nonjuice fruits, vegetables, dairy produ

120 ion of a plant-based diet index (emphasizing refined grains, potato/fries, sweets, sweetened drinks/j

121 wer consumption of less-healthy plant foods (refined grains, potatoes, sugar-sweetened beverages, swe

122 cts, fish and nuts, and lower consumption of refined grains, red and processed meat, sugar-sweetened

123 =4 servings/wk of green leafy vegetables and refined grains.

124 Our novel algorithm allows refined grouping of beta-cell autoantibody-positive chil

125 nucleotide polymorphisms (SNPs) enabling the refined grouping of the sampled tea accessions into five

126 he objective was to compute a novel and more refined GRS using fine mapping to include a large number

127 er period in which the behavior becomes more refined, habitual, and automatized.

128 The proposed method, refineD, has been found to produce consistent and substa

129 ultichamber carbon (MCC) microspheres with a refined hierarchical structure are realized here via a s

130 The synthesis of carbon microspheres with a refined hierarchical structure is still a problem in syn

131 graft survival probabilities conditional on refined HLA typing are achievable by combining SRTR and

132 ances in genetic analyses have significantly refined human type 1 diabetes (T1D) associated loci.

133 prkdc(-/-), il2rgalpha(-/-) model, including refined husbandry protocols for optimal growth and reari

134 rotein structure modeling, we have assembled refined I-band and H-zone models with unparalleled scope

135 >=7 cM IBD segments at quality comparable to Refined IBD and GERMLINE.

136 gle 5 takes 4.3 CPU days, followed by either Refined IBD or GERMLINE segment detection in 2.9 or 1.1

137 nphased individuals, and benchmarked it with Refined IBD, GERMLINE, and TRUFFLE on 3,000 simulated in

138 ns demonstrate how hydrogen positions can be refined in a crystalline system.

139 on achieved at the first step can be further refined in a second step, if necessary.

140 erges when exuberant contralateral axons are refined in an area- and layer-specific manner during pos

141 the AL is initially pre-patterned and later refined in an OSN-dependent manner.

142 to erythroid response assessment, which are refined in an overall more stringent manner.

143 Such oscillators have been refined in bacteria in vitro, however, these systems hav

144 We test its performance using: structures refined in explicit solvent, which are much better than

145 stream segregation that emerges in A1 and is refined in PEG.SIGNIFICANCE STATEMENT To interact with t

146 cess, present in primary auditory cortex and refined in secondary auditory cortex, in which sound rep

147 Furthermore, the carbon budget model refined in this study can be used to prioritize wetlands

148 of adult females (N = 116) and then further refined in two additional independent cohorts (male Vete

149 This type of synthesis allows more refined inferences to be made at small-area levels than

150 n cell fate decision will likely rely on the refined integration of experiments, large-scale omics da

151 Using MapBiomas 3.1 and recently refined IPCC carbon sequestration estimates, we mapped t

152 rboxyl group footprinter, benzhydrazide, and refined it with isotope encoding.

153 urobiology of ASD and sleep each become more refined, it is conceivable that sleep-derived metrics ma

154 identified and used to optimize WPRT through refined knowledge of the likely location of subclinical

155 As examining the human genome at more refined levels increases, so is the likelihood of encoun

156 We further refined life-history phenotypes using an unsupervised al

157 We discuss how advancing technologies have refined lineage-tracing studies, and how clonal analysis

158 A refined locus for adRP on Chr17q22 (RP17) was delineated

159 nthetic materials, Nature has evolutionarily refined macromolecular synthesis with perfect atomic res

160 We have refined many protein family boundaries, and have aligned

161 Using refined mass spectrometry methods, we map m7G to a singl

162 spholipids (PL) in tissue sections by use of refined matrix-assisted laser desorption ionization mass

163 ese results collectively provide a unifying, refined mechanism of RDV-mediated RNA synthesis inhibiti

164 ath toward better treatment personalization, refined mechanistic insights and improved outcomes.

165 A refined mesoscopic model for the cumulative effect of re

166 rror approach to treatment, moving to a more refined method that augurs a new era for patients and cl

167 We also present a refined method to determine cfDNA extraction efficiency

168 ds (SCFAs) was tested as a more targeted and refined microbiome therapy.

169 In summary, our refined model for P450 11B2 catalysis indicates isomeriz

170 s, we extend previous findings and propose a refined model in which RIM and Munc13-1 act in overlappi

171 on in human T cells, forming the basis for a refined model of CD8(+) T cell differentiation during CM

172 These results provide a refined model of DR organization and support a comparati

173 studies on the IA and ECL were guided by our refined model of the ectodomain/TMD interface and indica

174 ve human neutrophil progenitor and propose a refined model of the neutrophil developmental lineage in

175 A refined model using Monte Carlo parameter sampling was u

176 In a refined model, we added spatial regulation of microtubul

177 ntal observations, suggesting the need for a refined model.

178 , the inclusion of an additional entry type, refined modelling of discontinuous domains, and the deve

179 s and clonal growth assays are enabling more refined models of human hematopoietic lineage restrictio

180 will be important factors in developing more refined models of the S. pneumoniae-host interaction.

181 from predictions but additional data led to refined models.

182 ters within routine surveillance could allow refined monitoring of local subepidemics.

183 art of the 20th century (Brodmann, 1909) and refined more recently (Paxinos et al., 2012), the broad

184 . brucei are non-equivalent and enables more refined morphological analysis of mutant phenotypes.

185 his memory systems perspective offers a more refined, neurally plausible model of social cognition an

186 Here, we introduce a method for refined neuronal targeting that can be applied iterative

187 ive mill waste water on the stabilization of refined olive oil and on French fry quality during the f

188 oes were fried at 180 degrees C for 8 min in refined olive oil enriched by different concentrations o

189 ple of extra virgin olive oil, olive oil and refined olive pomace oil with the proposed method showed

190 retrained network was comparable to networks refined or trained from scratch using additional manuall

191 ts diagnosed with invasive breast cancer and refined OS estimates.

192 effectiveness of cerebral autoregulation, we refined oscillatory lower body pressure (LBP) to augment

193 Recent discoveries have refined our knowledge of Env conformational states, allo

194 ography and electron microscopy studies have refined our model of herpesvirus entry into cells, clari

195 Typhoid Fever in Africa (SETA) program have refined our understanding of age and geographic distribu

196 Advances in real-time imaging have refined our understanding of the intimate anatomic struc

197 refineD outperforms unrestrained relaxation strategy or

198 We refined ovarian stimulation and in vitro fertilization (

199 oviding rigorous confidence intervals on the refined parameters.

200 desirable properties and illustrate how more refined permutation schemes can be appropriate to obtain

201 Larger samples sizes, refined phenotypes and higher-resolution genome-screens

202 d transcriptome, and new approaches to study refined phenotypes for a greater appreciation of the dev

203 Refined phenotyping of allergic diseases may unravel nov

204 addition, the proposed scheme incorporates a refined physics model that considers the Coulomb-laser c

205 closely related to animals will allow a more refined picture of how the last common ancestor of anima

206 Our results suggest a refined picture of the platelet signal transduction netw

207 Our study presents a refined picture of the UV signature and underscores that

208 riety of possible poses, and then scores the refined poses.

209 Besides, refined PPMO contains remarkably greater concentrations

210 Results showed that refined PPMO has comparable physicochemical properties a

211 ester and trace metals) analyses proven that refined PPMO is safe to be consumed.

212 The overall quality assessment of refined PPMO showed that it is suitable for human consum

213 Based on our data, we propose a refined practical guideline for MRD assessment in RUNX1-

214 >97 %), mimicking the traditionally produced refined products.

215 Notably, a refined prognostic risk model that reconciles the level

216 patients (total, 1272 patients), and further refined prognostication based on the European Leukemia N

217 we present 25 synthetic capsid variants with refined properties, such as retrograde axonal transport

218 do not record these variables, however here, refined protocols allow us to test the hypothesis that p

219 re limited, therefore, quality assessment of refined red palm-pressed mesocarp olein (PPMO) is deemed

220 ng offers a perspective for a future of more refined redox medicine.

221 en target sequence and licking rather than a refined representation of sensory features.

222 ent a feature representation approach termed REFINED (REpresentation of Features as Images with NEigh

223 0) in dark reared subjects produced normally refined RFs, and blocking TrkB receptors in light-expose

224 the microbiological analysis, comparing the refined rye and wheat flours, the counting in the analys

225 owing several rounds of debate; and third, a refined search to target debated or rapidly updating iss

226 information encoded across PPC layers during refined sensorimotor behavior remains largely unknown.

227 DK inhibitors in living cells, and present a refined set of tool molecules to study CDK function.

228 Two refined signatures of four and two antibodies were capab

229 Two refined signatures were identified using stepwise logist

230 Two refined signatures with either four (LF2 and BGLF2 IgG,

231 Increasingly refined single-cell analytics have revealed diversity am

232 Although refined single-cell transcriptomic analyses of human pos

233 ac disease should lead to the development of refined, species-specific models for protein function an

234 Then we applied refined statistical methods, including some based on exo

235 , and to improve long-term patient outcomes, refined strategies for the monitoring of patients after

236 The refined strategy resulting from iterative improvements t

237 The refined structure revealed unmodeled densities between p

238 y map made from these sites aligned with the refined structure.

239 the top solutions are outputted as the final refined structures.

240 der and accompanying solvent, affording well-refined structures.

241 state of the tissue are urgently needed for refined studies of the underlying mechanisms.

242 ph and Xshift are more robust when detecting refined sub-clusters, whereas DEPECHE and FlowSOM tend t

243 n should be paid to sustained investments in refined supply of Co and secondary recovery.

244 Increasingly refined syn-BNP-based explorations of biosynthetic gene

245 It is therefore a more refined technique for DNA collection with the potential

246 e have recently developed new components and refined the existing ones to keep up with the computatio

247 their biological and immunological features, refined the lead candidate for further clinical developm

248 he structure at 1.6 angstrom resolution, and refined the model to R (work) and R (free) values of 17.

249 xtended peptide libraries, we identified and refined the peptide binding motifs for each of the four

250 We refined the position of a previously reported major locu

251 We also refined the reconstruction of tumor evolution, timing al

252 We refined the regions of 11q imbalance and identified the

253 ystal structure by molecular replacement and refined the resulting model against diffraction data to

254 We refined the structure of DDM and evaluated the activity

255 Then we refined the tE/I ratio to cell-type signatures in the mo

256 del B) the first tension-generating step and refined the two models by downhill simplex runs against

257 schema for more precise prognostication and refined therapeutic approaches.

258 Experiment 2a/b refined these observations by showing how isolated manip

259 Randomised trials have not further refined this choice.

260 assessment of ~30% of these participants, we refined this set of markers from 343 to 28, based on the

261 -day consensus meeting (31 stakeholders) and refined through a checklist pilot (34 participants).

262 in a consensus meeting (31 stakeholders) and refined through a checklist pilot (34 participants).

263 l devices or systems, which are successively refined through a cycle of designing, building, and test

264 The enumerative algorithm was tested and refined through feedback from two rounds of large-scale

265 emission as a treatment target and should be refined through future research, patient input, and clin

266 elphi procedure involving 38 experts and was refined through piloting.

267 Before this processing, olfactory input is refined through the feedback provided by amygdala cortic

268 using single-wavelength anomalous dispersion refined to 1.96 angstrom resolution.

269 if the contextual image of the tracks can be refined to a level comparable to that of the target, man

270 sm on FXR and PPARdelta and was structurally refined to a potent and balanced FXR/PPARdelta activator

271 our current range of blunt tools need to be refined to bring about long-term success in treating arr

272 provides a solid basis which can be further refined to concur with higher-throughput single cell gen

273 entify aspects of the protocol that could be refined to enhance accuracy.

274 y, gross and fine movements may be modularly refined to function together.

275 research to illustrate how FC methods can be refined to improve inferences about neural mechanisms, w

276 ground selection and selective sweeps, to be refined to include harmful recessive mutations creating

277 on, gastric variceal classification has been refined to include inflow and outflow based hemodynamic

278 active materials and EES devices need to be refined to realize the true promise as well as the limit

279 Reference genomes are refined to reflect error corrections and other improveme

280 flexible nature means that our model can be refined to simulate specific systems and could have appl

281 esults suggest that curvilinear features are refined to the same order of precision as that of the ta

282 -handed assessment of the potential value of refined tools of this sort cannot currently be made beca

283 , greater than expected homeostatic fitness, refined transcription factor dependencies, and a distinc

284 lace high confidence validated SV calls on a refined tumor phylogeny tree.

285 tribution in the cell, they cannot provide a refined understanding of signaling at distinct subcellul

286 Collectively, our findings provide a refined understanding of the interplay between the struc

287 s a foundation for further developing a more refined understanding of the molecular biology of fruit

288 The refined unit-cell parameters reflected a decrease in the

289 ed as computational models, which can now be refined using recently available data from transgenic ma

290 Using a refined version of a previously described WDD-binding am

291 Here we present an updated and refined version of this approach, mCSM-AB2, capable of a

292 This new understanding has led to a refined view of how NF-kappaB and cell death signaling a

293 ronal subpopulations that promise to offer a refined view of the circuit mechanisms surrounding depre

294 Herein, we use a series of refined virus mutants to define the active isoform of MH

295 rotonin in healthy adults when compared with refined wheat.

296 There was studied dough made from refined white and brown wheat flours of different granul

297 Obtained data confirmed that fine refined white flour dough had high ability to elongate a

298 as a first-line approach, followed by a more refined whole genome sequencing analysis.

299 tional topography of association networks is refined with age, allowing accurate prediction of unseen

300 e nuclear pore complex (NPC) continues to be refined with cryo-EM and x-ray crystallography, in vivo