ライフサイエンスコーパス: refractoriness

1 stricted by a natural resistance phenomenon (refractoriness).

2 ected waves, all-or-none responsiveness, and refractoriness.

3 ndothelial vulnerability contributes to GVHD refractoriness.

4 nt of the number of prior lines and level of refractoriness.

5 ts is closely associated with corticosteroid refractoriness.

6 alities, because all spiking neurons exhibit refractoriness.

7 th a 10-ms decrement until AT termination or refractoriness.

8 ding assays are not associated with platelet refractoriness.

9 cer initiation, progression, and therapeutic refractoriness.

10 t ventricular extrastimuli were delivered to refractoriness.

11 regionally to result in large dispersion of refractoriness.

12 of them target the VEGF pathway and lead to refractoriness.

13 n responsiveness in a mouse model of insulin refractoriness.

14 sponse) and considerable post-repolarization refractoriness.

15 on potential amplitudes, latency and in axon refractoriness.

16 pment of atrial-specific post-repolarization refractoriness.

17 odel predicted maximal spatial dispersion of refractoriness.

18 y conduction by promoting postrepolarization refractoriness.

19 re initiated immediately after recovery from refractoriness.

20 e myeloid cells is also sufficient to confer refractoriness.

21 between platelet transfusions, and platelet refractoriness.

22 echanism contribute to spark termination and refractoriness.

23 ) whose coupling interval just exceeded RSPV refractoriness.

24 suggest a common mechanism underlying G-CSF refractoriness.

25 ssociated with both elevated P2' and reduced refractoriness.

26 nistered for up to 8 weeks or until platelet refractoriness.

27 2 drive trains with 6 extra-stimuli down to refractoriness.

28 the period of illumination and does not show refractoriness.

29 hly immunogenic stimulus), or until platelet refractoriness.

30 al information on the mechanisms of surgical refractoriness.

31 onor platelets prevented alloimmune platelet refractoriness.

32 ts by delaying repolarization and prolonging refractoriness.

33 account for the immune mechanism in platelet refractoriness.

34 elated with improved callosal conduction and refractoriness.

35 trial voltage, conduction velocity (CV), and refractoriness (7 sites, 2 cycle lengths), vulnerability

36 osure to short winter day lengths results in refractoriness, a spontaneous reversion to long-day phys

37 A universal property of spiking neurons is refractoriness, a transient decrease in discharge probab

38 fixed heterogeneity; namely, the gradient of refractoriness across the ischemic border zone (BZ).

39 ing preferences and the cost and efficacy of refractoriness affects the long-term prevalence of malar

40 evels of HLA antibodies were associated with refractoriness among LCA(+) recipients.

41 els of HLA or HPA antibodies did not predict refractoriness among LCA(-) recipients, although higher

42 TNF-alpha expression might contribute to HCQ refractoriness and a better response to QC.

43 RA refractoriness and aberrant histone acetylation were att

44 etoclax or higher (>/=400 mg/d), fludarabine refractoriness and complex karyotype were associated wit

45 history of AF or risk factors for AF, atrial refractoriness and conduction were measured, followed by

46 er methods of preventing alloimmune platelet refractoriness and demonstrated that successful methods

47 causes accelerated conduction with prolonged refractoriness and electric instability.

48 ly relevant environments to predict clinical refractoriness and enabling platforms for screening drug

49 erimental observations we present, including refractoriness and increase of puff frequency during the

50 his resulted in enhanced post-repolarization refractoriness and more effective Na-channel inhibition.

51 properties of cells such as restitutions of refractoriness and of conduction velocity are given via

52 Ca(2+) release and uptake, and the other on refractoriness and other properties of Ca(2+) sparks.

53 lated with some clinical characters, such as refractoriness and pleural effusion.

54 ed dynamically induced spatial dispersion of refractoriness and predisposed the heart to the developm

55 t and AP14145 significantly prolonged atrial refractoriness and reduced AF duration without affecting

56 tive incidence of failure (including primary refractoriness and relapse), event-free survival, and ov

57 light-induced response in that both exhibit refractoriness and repriming depends upon endothelium-de

58 lcholine delivery into the AVN increased AVN refractoriness and significantly decreased ventricular r

59 promoting cardiac substrates (e.g. prolonged refractoriness and spatiotemporal dispersion of action p

60 t on ejaculate evolution whereby high female refractoriness and sperm competitiveness are mutually ex

61 om mechanical compression, is independent of refractoriness and spike-rate adaptation, and is apparen

62 al utility in the early identification of CS refractoriness and subclinical inflammation in patients

63 physiological has effects on the threshold, refractoriness and superexcitability of the shortest lat

64 Whether refractoriness and the associated serial ballistic hypot

65 on of abbreviated ryanodine receptor channel refractoriness and the preceding synchronous stimulated

66 voltage changes; and the ability to control refractoriness and the shape of the cardiac action poten

67 ary to the development of postrepolarization refractoriness, and an increase in diastolic threshold o

68 conduction, lower activation threshold, less refractoriness, and improved response to high-frequency

69 n and Na(+)-channel dysfunction), electrical refractoriness, and impulse generation.

70 ink mismatch, spatiotemporal distribution of refractoriness, and rate-sensitive electric instability,

71 with 3 basic properties (random activation, refractoriness, and recruitment) produces the classic ph

72 bbreviation of action potential duration and refractoriness, and reduce the affinity of the channels

73 allenged by insufficient efficacy, intrinsic refractoriness, and resistance.

74 with severe gout, allopurinol intolerance or refractoriness, and serum uric acid concentration of 8.0

75 achycardia cycle: when a PAC is timed to His refractoriness, any perturbation of the subsequent His i

76 period nor the link between excitability and refractoriness are properly understood.

77 human monocytes we detected two forms of TNF refractoriness, as follows: absolute tolerance was selec

78 ed effector CD8 T cells probably acquire TCR refractoriness at the time the patient is experiencing f

79 wn to cause both a rapid reduction in atrial refractoriness (atrial electrical remodeling) and a more

80 such as action potential duration gradients, refractoriness barriers, conduction velocity restitution

81 Dispersion of refractoriness between apex and base was markedly reduce

82 bbreviation of action potential duration and refractoriness by acetylcholine combine to produce rapid

83 Reducing spatial dispersion of refractoriness by modulating restitution parameters can

84 Verapamil decreased spatial dispersion of refractoriness by reducing action potential duration and

85 adolescents, and young adults; (2) platelet refractoriness can be defined as a corrected count incre

86 y, that the temporal correlations imposed by refractoriness can play a significant role in shaping sp

87 ation that I(Ks)-mediated postrepolarization refractoriness can promote wavebreak formation and fibri

88 of changing: C-signal strength, sensitivity/refractoriness, cell density, and noise upon the formati

89 days of sinus rhythm was just sufficient for refractoriness changes to reverse fully in all goats.

90 and high-risk features, such as fludarabine refractoriness, complex karyotype, or abnormalities of c

91 e click stimulation, suggesting that spindle refractoriness contributes to this protective mechanism.

92 and numerically how preexisting gradients in refractoriness control the vulnerable window for unidire

93 fection, and that NK cell responsiveness and refractoriness correlate to the antiviral effectiveness

94 yet to be determined whether codeine-induced refractoriness could be exploited to desensitize MRGPRX2

95 The equivalent dispersion of refractoriness created dynamically in homogeneous tissue

96 Postrelease Ca(2+) signaling refractoriness critically influences the occurrence of D

97 Some will exhibit platelet transfusion refractoriness, defined as inappropriately low platelet

98 n either reduce or enhance the dispersion of refractoriness depending on its propagation direction wi

99 , number of prior therapies, and fludarabine refractoriness did not influence the response rate.

100 Shortened Ca(2+) signaling refractoriness due to RyR2 phosphorylation and oxidation

101 nistered acetylcholine on AVN conduction and refractoriness during sinus rhythm and AF.

102 maps were constructed to assess gradients of refractoriness during VF.

103 For ratios less than approximately 0.9, refractoriness enhanced entrainment and this enhancement

104 y and behaviorally relevant factors: spiking refractoriness, event-locked firing rate non-stationarit

105 in Anopheles gambiae mosquitoes that confer refractoriness (failure of oocyst development in mosquit

106 premature beat (APB) given during His bundle refractoriness followed by resetting of an antidromic ta

107 ent angiogenic programs that induce the drug refractoriness found in cancers resistant to anti-angiog

108 Fludarabine refractoriness (FR) represents an unsolved clinical prob

109 n-mediated dissociation of drive and disease refractoriness functions.

110 Introducing refractoriness genes in areas of the genome void of inve

111 ity (P1', P2', fecundity, remating rate, and refractoriness), genotyped at 70 polymorphic markers in

112 parasites and that the frequency of natural refractoriness genotypes may be higher in the basin regi

113 Seizure refractoriness implies that extramedial regions are capa

114 Here we investigated mechanisms of RA refractoriness in 14 lung cancer cell lines.

115 gy to overcome stromal-mediated chemotherapy refractoriness in aggressive MCL.

116 f excitation, and induced postrepolarization refractoriness in atria but not in ventricles.

117 rapy, and prognostication of time to hormone refractoriness in castrate disease and overall survival.

118 erebral endothelial cells displayed a marked refractoriness in chemokine production and secretion, wh

119 s are strong predictors of poor survival and refractoriness in chronic lymphocytic leukemia (CLL) and

120 the role of dispersion of repolarization and refractoriness in facilitating re-entry arrhythmias.

121 dopted the double stimulus paradigm to study refractoriness in human neuromotor control.

122 ent (I(Ks)) contribute to postrepolarization refractoriness in isolated cardiomyocytes.

123 e whether low-level antibodies could predict refractoriness in longitudinal panels from 170 lymphocyt

124 ocardial (M) cells formed zones of increased refractoriness in LQT2, producing steep spatial gradient

125 acetylation consistently correlated with RA refractoriness in lung cancer cell lines.

126 beta-adrenergic regulation of Ca(2+) release refractoriness in mouse myocytes.

127 o beta-adrenergic regulation of Ca2+ release refractoriness in mouse myocytes.

128 Here we studied regulation of Ca(2+) spark refractoriness in mouse ventricular myocytes by examinin

129 Here we studied regulation of Ca2+ spark refractoriness in mouse ventricular myocytes by examinin

130 nt effects are attributed to the build-up of refractoriness in representations with shared neural cir

131 n velocity restitution promote dispersion of refractoriness in response to multiple extrasystoles, an

132 ndependent predictor of survival and disease refractoriness in several ALL patient cohorts.

133 analysis has been presented that quantifies refractoriness in sustained control tasks and discrimina

134 istant HER2(+) clones exhibiting stable drug refractoriness in vitro and in vivo Genomic comparisons

135 AD presence do not cause large dispersion of refractoriness in well-coupled tissue.

136 or conduction block is spatial dispersion of refractoriness, in this study we investigate how the fir

137 us and AGAP001476 failed to reverse the near refractoriness induced by the knockdown of cactus, sugge

138 latelets per L, aged at least 18 years, with refractoriness, ineligibility to receive treatment with

139 en 0 and 22 +/- 6 ms following recovery from refractoriness initiated arrhythmic activity specificall

140 In intact hearts, RyR refractoriness initiates SR Ca(2+) release alternans tha

141 sustained manual tracking involves repeated refractoriness (insensitivity to sensory information for

142 manual tracking incurs substantial, serial, refractoriness (insensitivity to sensory information of

143 ems and constraints, we propose that central refractoriness is an appropriate control mechanism for a

144 Inherent anti-VEGF refractoriness is associated with infiltration of the tu

145 We posit that spindle refractoriness is crucial for protecting memory reproces

146 Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accu

147 xtrasystole can create a large dispersion of refractoriness leading to conduction block of a subseque

148 duration, depolarization of E(K1) increased refractoriness, leading to a slowing of VF, which effect

149 hanced dispersion of repolarization (DR) and refractoriness may be a unifying mechanism central to ar

150 d, dose, and administration site, nociceptor refractoriness may last from minutes up to months, sugge

151 These forms of refractoriness may provide a cellular paradigm for resol

152 ate or which have prematurely recovered from refractoriness might release Ca(2+) later during the act

153 We find that neither refractoriness nor spike-rate adaptation is responsible

154 lack of peak clipping is due neither to ANF refractoriness nor to spike-rate adaptation on time scal

155 Finally, MDP stimulation induced refractoriness not only to MDP, but also to iE-DAP stimu

156 usceptible model to overcome the paradoxical refractoriness of B cell lines to experimental KSHV infe

157 The refractoriness of bacterial infections to antibiotic the

158 ned coupling intervals, suggesting a reduced refractoriness of Ca(2)(+) release events; (3) have a re

159 erogeneity of Ca(2+) cycling attributable to refractoriness of Ca(2+) release from corbular sarcoplas

160 hyperactivity of RyRs and thereby shortened refractoriness of Ca(2+) release in cardiomyocytes from

161 content and ICa-L, another factor, possibly refractoriness of Ca2+ release from the SR contributes.

162 Time-dependent refractoriness of calcium (Ca(2+)) release in cardiac my

163 Time-dependent refractoriness of calcium (Ca2+) release in cardiac myoc

164 Refractoriness of calcium release in heart cells is alte

165 We examined refractoriness of calcium release in mouse ventricular m

166 We found that refractoriness of calcium release is abbreviated by stim

167 nues to be associated both with presence and refractoriness of cutaneous lupus erythematosus to thera

168 equency at the network level by reducing the refractoriness of excitatory transmission.

169 servation may provide an explanation for the refractoriness of human beta-cells to proliferation.

170 n rise, together with the relative treatment refractoriness of IBM, to a competing view that IBM is n

171 pture depends critically upon the stochastic refractoriness of its 30,000 sampling units (microvilli)

172 nzoic acid) porphyrin (MnTBAP) decreased the refractoriness of LEW rat peritoneal cells to T. gondii

173 fatty acid-derived CyPGs and the well-known refractoriness of LSCs to currently used clinical agents

174 The intrinsic refractoriness of naive T cells for cytokine production

175 ells and whether it affects the response and refractoriness of NK cells to IFN-alpha-based therapy of

176 sychiatric neurosurgery, ensuring documented refractoriness of patients, proper consent procedures th

177 The refractoriness of PBMCs to DM was examined after precond

178 al motor thalamic nuclei nicely explains the refractoriness of PRS rats to haloperidol-induced catale

179 ostsynaptic currents: vesicle heterogeneity, refractoriness of release sites, and superpriming.

180 their association with Ca(2+) channels, and refractoriness of release sites, while accounting for da

181 lation, medical complications, etiology, and refractoriness of seizures were not.

182 tilation, Status Epilepticus Severity Score, refractoriness of seizures, etiology of seizures, or med

183 Refractoriness of solid tumors, including colorectal can

184 arcoplasmic reticulum (SR) refilling whereas refractoriness of spark triggering depends on both refil

185 arcoplasmic reticulum (SR) refilling whereas refractoriness of spark triggering depends on both refil

186 ck interface) is unnecessary, we ask whether refractoriness of substantial duration (~200 ms) is evid

187 ptor mechanism is required for the prolonged refractoriness of the MEK/ERK and phosphatidylinositol 3

188 Refractoriness of the memory T cells to TCR activation w

189 d cellular and molecular events that mediate refractoriness of tumors to anti-angiogenic therapy.

190 urthermore, for a set [Ca(2+)](SR) level the refractoriness of wave occurrence (Ca(2+) wave latency)

191 ise: "randomness" (of Ca spark activation), "refractoriness" (of a CRU after a Ca spark), and "recrui

192 stimulus and spike history dependence (e.g., refractoriness) of the spike trains.

193 the stimulus period predicted the impact of refractoriness on entrainment and synchronization.

194 us activity can be modeled as resulting from refractoriness operating on a non-Poisson stochastic poi

195 representations, and that localized spindle refractoriness optimizes oscillatory interactions that s

196 F duration without affecting the ventricular refractoriness or blood pressure in pigs subjected to 7

197 nts are deprived of treatment due to primary refractoriness or development of resistance during thera

198 Several patients, however, display treatment refractoriness or relapse soon after obtaining a respons

199 ent findings on the role of myeloid cells in refractoriness or/and acquired resistance to such therap

200 s or no EADs with a very small dispersion of refractoriness, or synchronize regionally to result in l

201 In the recovery cycle, refractoriness (P < 0.0002) and superexcitability (P < 0

202 ected for all phenotypes except male-induced refractoriness (P = 0.053).

203 Ryanodine receptor (RyR) refractoriness played a key role in the onset of SR Ca(2

204 delayed myocardial activation and dispersed refractoriness predispose to reentrant excitation that m

205 ntractility, left atrial dilation, fibrosis, refractoriness prolongation, and AF promotion occurred i

206 nd improved postinjury strength-duration and refractoriness properties only in N2 CAPs.

207 sed intranodal fibrosis and heterogeneity of refractoriness, provides substrates for SAN reentry.

208 refractory period (ERP), post repolarization refractoriness (PRR), maximum rate of rise of the action

209 Identification of P. falciparum-refractoriness QTL in natural An. gambiae mosquitoes is

210 The only factors that reduced platelet refractoriness rates were increasing the dose of platele

211 py, chemotherapeutic resistance, and hormone refractoriness remains essential in the rational design

212 ical role in the timing of seasonal rhythms, refractoriness remains poorly understood.

213 f puff generation and the recovery rate from refractoriness, respectively.

214 In daylight, refractoriness sacrifices sensitivity to enhance intensi

215 the heart, markedly enhancing dispersion of refractoriness so that ectopic beats have a high probabi

216 terized by a high and rapid development of a refractoriness state and known for their poor prognosis.

217 emale postmating responses to the ejaculate: refractoriness stimulation is impaired, but offspring pr

218 ical and laboratory measures predict steroid refractoriness (such as stool frequency 3-8/day and C-re

219 Currently, refractoriness, such as the Psychological Refractory Per

220 t-threshold relationship and recovery cycle (refractoriness, superexcitability and late subexcitabili

221 t-threshold relationship and recovery cycle (refractoriness, superexcitability and late subexcitabili

222 ggering an LCS also depends on recovery from refractoriness that appears after prior activation.

223 s functional substrates dependent on altered refractoriness that cause abnormalities in activation an

224 The uterine refractoriness that follows the receptive state at high

225 ne thrombocytopenia and platelet transfusion refractoriness) the causative idiotypic platelet-reactiv

226 rength of Ca(2+) release, ryanodine receptor refractoriness, the magnitude of initiating stimulus, or

227 c acid level, and allopurinol intolerance or refractoriness, the use of pegloticase 8 mg either every

228 Among those diagnosed with immune refractoriness, there is no standard method for identify

229 rld intensity changes that reduce microvilli refractoriness, these performance gains are submaximal a

230 apid spread of transgenes conferring disease refractoriness throughout wild populations.

231 ion induced heterogeneous changes in the SAN refractoriness; thus, competing atrial or SAN pacemaker

232 These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by t

233 y tumor or stromal cells is a determinant of refractoriness to anti-VEGF-A treatment.

234 d CD11b(+)Gr1(+) myeloid cells contribute to refractoriness to antiangiogenic therapy with an anti-VE

235 analyses, bulky lymphadenopathy (>=5 cm) and refractoriness to B-cell receptor inhibitor (BCRi) thera

236 reates a negative feedback loop that induces refractoriness to chronic stimulation of the cAMP pathwa

237 clinical course and poor outcome due to its refractoriness to conventional chemotherapy regimens.

238 nchyme contributes to disease chronicity and refractoriness to corticosteroids.

239 th advanced multi-drug resistant disease and refractoriness to currently available combination regime

240 myeloma (MM) cells in vitro irrespective of refractoriness to dexamethasone and chemotherapy.

241 kemia cells to proliferate and explain their refractoriness to differentiation-inducing agents.

242 ted to the weakened angiogenic response, and refractoriness to diminished endoglin signaling was acco

243 Refractoriness to DM was achieved by means of repeated e

244 s preconditioning of PBMCs with MSCs, caused refractoriness to DM.

245 bition by c-Myc shRNA established that their refractoriness to DNTCF was because of their independenc

246 Refractoriness to epinephrine could be corrected by nitr

247 Atrial Protease 1 (MatRAP1), reduces female refractoriness to further copulation, so that a signific

248 lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin toler

249 ting switch in females, inducing a permanent refractoriness to further mating and triggering egg-layi

250 f its biosynthesis in males, oviposition and refractoriness to further mating in the female are stron

251 C3a or FcepsilonRI aggregation) resulted in refractoriness to further stimulation by the same or ano

252 strong and sustained induction of SOCS1 and refractoriness to further stimulation with IFN-lambda3.

253 ed Shh activity is also required to maintain refractoriness to Gremlin expression in response to Bmp

254 nt features-such as sustained proliferation, refractoriness to growth suppressors, resistance to cell

255 ate nonlytic effector phenotypes from target refractoriness to immune lysis.

256 sorder, perhaps contributing to its relative refractoriness to immune-directed therapies previously r

257 bution of refractory periods, the ability of refractoriness to improve temporal coding is restricted

258 in seasonally breeding mammals by triggering refractoriness to inhibitory short photoperiods during m

259 s are associated with an aggressive onset, a refractoriness to intravenous immunoglobulin, and tremor

260 ng to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion

261 nd 2 genes, PTGFR and MMP-1, were related to refractoriness to latanoprost.

262 Refractoriness to LEN, or resistance to both LEN and BOR

263 A unique feature of Pincher-Trk endosomes is refractoriness to lysosomal degradation, which ensures p

264 ize that new QTL may be involved in mosquito refractoriness to malaria parasites and that the frequen

265 id carcinoma (ATC) characterized by complete refractoriness to multimodal therapeutic approaches.

266 onferring insecticide resistance or possibly refractoriness to parasites and (2) to reveal novel insi

267 which would provide cattle with a degree of refractoriness to perchlorate.

268 d be used to spread desirable genes, such as refractoriness to Plasmodium infection, through target p

269 Refractoriness to platelet transfusions developed in 27%

270 metinib (AZD6244, ARRY-142886) could reverse refractoriness to radioiodine in patients with metastati

271 Nevertheless, a high rate of refractoriness to recombinant human interleukin-12 occur

272 he overall response rate and to overcome the refractoriness to recombinant human interleukin-12 thera

273 0A with the male's influence on the female's refractoriness to remating (refractory), Esterase-6 with

274 amous populations in their ability to induce refractoriness to remating in females, but they were inf

275 as of the stones themselves, associated with refractoriness to shockwave lithotripsy are fairly well

276 e expression is associated with reproductive refractoriness to short day lengths.

277 Vernal refractoriness to short photoperiods reestablished summe

278 Successful mating induces lifetime refractoriness to subsequent insemination by other males

279 ure to LPS induces a transient state of cell refractoriness to subsequent LPS restimulation, known as

280 nary LPS exposure does not induce whole-body refractoriness to systemic LPS, because i.t. administrat

281 with the wAlbB strain of Wolbachia, inducing refractoriness to the human malaria parasite Plasmodium

282 y in their Myc levels, which correlates with refractoriness to therapy and poor prognosis.

283 mia (CML) whose disease manifests relapse or refractoriness to therapy.

284 s of naturally occurring alleles that confer refractoriness to transmission can reduce transmission b

285 eous cell populations demonstrate short-term refractoriness to up-front dose delivery, but "resensiti

286 e contributions of seizure etiology, seizure refractoriness, use of mechanical ventilation, anestheti

287 Short PR/AH with increased refractoriness was additionally found in 3 patients with

288 This refractoriness was associated with decreased D1 receptor

289 Platelet refractoriness was associated with lymphocytotoxic antib

290 CS refractoriness was defined as an ocular reactivation of

291 oreduction in preventing alloimmune platelet refractoriness was evaluated in a canine model.

292 s progesterone, which confirmed that uterine refractoriness was fully attributable to the underlying

293 In sustained control refractoriness was only found when the target reverses d

294 Ventricular refractoriness was prolonged, along with both QRS and QT

295 ng interval decremented by 20 to 30 ms until refractoriness was reached.

296 d, but no increases in atrial or ventricular refractoriness were detected, despite achieving plasma c

297 blocking was consistent with a collision or refractoriness when one motoneuron tried to excite the f

298 Spatial dispersion of refractoriness, which is amplified by genetic diseases,

299 Optical mapping revealed cardiac refractoriness with loss of 1:1 capture above 3 Hz, and

300 one demonstrated that prolongation of atrial refractoriness with MK-0448 was markedly attenuated in t