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1 ine of platinum-based chemotherapy (platinum-refractory).
2 ), and 128 (87%) of 148 patients were double refractory.
3 or an immunomodulatory drug, or were double refractory.
4 ypes, including glioblastoma, remain largely refractory.
8 but the development of severe and/or steroid-refractory acute graft-versus-host disease (aGVHD) remai
10 ic stem cell transplantation without steroid-refractory acute graft-versus-host disease and without e
12 approved for the treatment of corticosteroid-refractory acute GVHD in adult and pediatric patients 12
15 aediatric patients with heavily relapsed and refractory acute myeloid leukaemia suggests that this co
22 atients had disease that had relapsed or was refractory after the receipt of up to five previous ther
23 he effect of three neuroleptic strategies on refractory agitation in patients with cancer with termin
24 erson Cancer Center (Houston, TX, USA), with refractory agitation, despite low-dose haloperidol, were
25 least 12 years with grades II to IV steroid-refractory aGVHD were eligible to receive ruxolitinib or
26 ith historical data in patients with steroid-refractory aGVHD who otherwise have dismal outcomes.
27 re used to manage complications of medically refractory AKI and CRS and may restore normal electrolyt
37 ck an initial response to therapy (i.e., are refractory), and although the mean survival of MM patien
40 port (exposed) were matched with patients in refractory arrest (at risk of intra-arrest transport) at
41 ective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis
42 The results demonstrate that children with refractory asthma and neutrophilic inflammation had a BA
49 and histone deacetylase inhibitor abrogated refractory B-1b cell immune responses against Gal-glycan
50 TLR inhibitor together with CNI abrogated refractory B-1b cell immune responses against the ABO-bl
52 therapy has proven effective in relapsed and refractory B-cell malignancies, but resistance and relap
54 notherapeutic strategy for treating multiple refractory blood cancers, but further advances are requi
58 ide a paradigm for imaging latent, treatment-refractory cancer cells, suggesting that DNP-MRSI provid
61 own survival benefit in select patients with refractory cardiac arrest but there is insufficient data
64 namics and microcirculation in patients with refractory cardiogenic shock and compared the evolutions
67 m cord blood to 11 patients with relapsed or refractory CD19-positive cancers (non-Hodgkin's lymphoma
68 n indication for SBCE) to newer ones such as refractory celiac disease, hereditary polyposis syndrome
73 rs of age diagnosed with H(1) -antihistamine-refractory chronic spontaneous urticaria (without induci
74 g of the cohort of patients with relapsed or refractory classical Hodgkin lymphoma was a post-hoc dec
75 phase 1b/2 study, 134 patients with relapsed/refractory CLL or SLL (median age, 66 years [range, 42-8
76 and June 2016, 42 patients with relapsed or refractory CLL were enrolled in this study and 38 were i
78 demonstrate mixed efficacy in patients with refractory CMV infection suggesting that letermovir may
79 el therapeutic options for drug-resistant or refractory CMV infection, including maribavir, letermovi
81 single infusion cohort, 3 of 6 patients with refractory CRS concurrent with culture-positive sepsis d
83 n = 2; chronic lymphoid leukemia, n = 1; and refractory cytopenia with multilineage dysplasia, n = 1)
87 high proportion of patients with relapsed or refractory diffuse large B-cell lymphoma ineligible for
89 NA-seq on skin and blood from a patient with refractory DiHS/DRESS, identifying the JAK-STAT signalin
90 e large B-cell lymphoma, who relapsed or had refractory disease after previous treatment with one to
92 patient underwent to colectomy for a medical refractory disease and the histological examination of t
94 chemotherapy group (hazard ratio for primary refractory disease or first occurrence of progression, r
95 5 years or older, 181 (67%) had chemotherapy-refractory disease, and seven (3%) had secondary CNS inv
103 leukin-33 (IL-33) plays an important role in refractory disorders such as asthma, allergic rhinitis a
104 ifier to pretreatment biopsies from relapsed/refractory DLBCL patients receiving avadomide (NCT014215
105 , demonstrated clinical activity in relapsed/refractory DLBCL patients, independent of COO subtypes.
106 nuclear export, in patients with relapsed or refractory DLBCL who had no therapeutic options of poten
107 events profile in patients with relapsed or refractory DLBCL who received at least two lines of prev
108 We describe two patients who presented with refractory dysphagia due to malignant proximal oesophage
109 n patients with COPD who experience advanced refractory dyspnea despite otherwise optimal therapy.Con
110 otential therapy for patients with rituximab-refractory EBV-associated lymphoma after transplantation
111 ering event, rare patients develop treatment-refractory electrical storm and their hemodynamic instab
112 orporeal membrane oxygenation-supported drug-refractory electrical storm patients, 42% survived 6 mon
113 from the sensorimotor cortex of people with refractory epilepsy and classified five facial expressio
114 dividuals had neurodegenerative disease with refractory epilepsy, developmental regression, and reduc
115 surgical planning in patients with medically refractory epilepsy; however, their spatial and temporal
116 eye movement (REM) sleep, in six medication-refractory focal epilepsy patients during epilepsy monit
118 patients with previously treated relapsed or refractory follicular lymphoma (grade 1, 2, or 3a) were
120 )) that have higher vapor pressures than the refractory form (i.e., UO(2)) depending on the oxygen ab
121 could be used to enhance immune clearance of refractory fungal, mycobacterial, and viral infections.
126 A single-phase body-centered-cubic (BCC) refractory HEA, NbTaTiVZr, using thermodynamic modeling
127 In total, 61 other patients (52%) developed refractory heart failure to disabling New York Heart Ass
128 centers involving patients with relapsed or refractory HL and administered CD30.CAR-Ts after lymphod
130 vity in paediatric patients with relapsed or refractory Hodgkin lymphoma, consistent with experience
133 zygous familial hypercholesterolemia who had refractory hypercholesterolemia, with a screening LDL ch
135 randomized trial of patients with treatment-refractory IBS with predominant bloating, FMT relieved s
137 y off-label use of Tpo-RAs for severe and/or refractory ITP during pregnancy seems safe for both moth
138 ological events in patients with relapsed or refractory large B-cell lymphomas, including those with
140 rospectively from all patients with relapsed/refractory LBCL who underwent leukapheresis as of Septem
141 ical responses in patients with relapsed and refractory LCH treated with BRAF or MEK inhibitors, alth
142 or biopsy specimens from 5,954 patients with refractory malignancies at 1,117 accrual sites were anal
143 f CAR T cells for patients with relapsed and refractory mantle cell lymphoma following prior failed B
145 hat the main constituent is a mix of ice and refractory materials characterized by high porosity (70-
146 table and pre-existing NGFR(hi) multitherapy-refractory melanoma subpopulation, which ought to be eli
147 ed a total of 111 patients who had treatment-refractory meningioma and received SSTR-targeted PRRT.
150 f)(x) are high strength and damage resistant refractory metals that also exhibit superconductivity wi
152 n patients with heavily pretreated, platinum-refractory metastatic urothelial carcinoma with measurab
154 years or older with relapsed or relapsed and refractory multiple myeloma (as per International Myelom
155 melflufen plus dexamethasone in relapsed and refractory multiple myeloma (RRMM), a population with an
156 =18 years) if they had confirmed relapsed or refractory multiple myeloma according to International M
157 vival versus Kd in patients with relapsed or refractory multiple myeloma and was associated with a fa
159 Europe, Australia, and Asia with relapsed or refractory multiple myeloma were randomly assigned 2:1 t
166 findings provide further explanation of the refractory nature of respiratory illnesses in smokers an
170 antibodies in heavily pretreated relapsed or refractory non-Hodgkin lymphoma warrants further investi
171 ogically confirmed CD20-positive relapsed or refractory non-Hodgkin lymphoma, had an Eastern Cooperat
173 r deep brain stimulation (DBS) for treatment-refractory obsessive-compulsive disorder (OCD) can be co
176 nificant improvement in severe cases (HDIVig refractory or cases with central nervous system or cardi
178 s shown remarkable activity in patients with refractory or relapsed acute lymphocytic leukaemia.
179 s of apoptosis, especially in the context of refractory or relapsed BRAF(V600E)-driven melanoma.
181 All received letermovir in the context of a refractory or resistant CMV infection including asymptom
184 aive patients and 23 (25%) of 92 relapsed or refractory patients discontinued treatment on study.
185 atment-naive patients and 50% of relapsed or refractory patients had undetectable minimal residual di
186 ponse and 86 (93% [86-98]) of 92 relapsed or refractory patients per both the modified 3rd and 6th IW
188 loma cells from newly diagnosed and relapsed/refractory patients, including plasma cells bearing the
189 aive patients and 21.5 months in relapsed or refractory patients, the median progression-free and ove
197 vention was prolongation of atrial effective refractory periods, at least in part attributable to the
201 challenges of using CAR-T therapy to manage refractory PTLD in SOT recipients and its possible compl
202 e drastically improved outcomes for relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (AL
203 ly reported durable responses in relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) pati
206 hich we designate as persistent inflammatory refractory RA (PIRRA); and those with supposed refractor
207 Future approaches towards the definition of refractory RA and the application of single-cell and int
210 fractory RA (PIRRA); and those with supposed refractory RA who have continued disease activity that i
214 tients with aggressive metastatic disease or refractory/relapsed neuroblastoma currently face a disma
216 a history of developmental delay and medical refractory seizures since birth most recently presented
218 rally confirmed, PD-L1-positive, relapsed or refractory solid tumour or lymphoma, and a Lansky Play/K
220 anaesthetic agents are typically titrated in refractory status epilepticus to achieve either seizure
223 istent increase in vagal tone that may cause refractory symptoms even in a normal heart patient.
225 netic and cellular) that cause anticoagulant-refractory thrombotic antiphospholipid syndrome are now
228 rmation Processing Battery in 145 unilateral refractory TLE patients undergoing epilepsy surgery, a v
229 y surgery, a validation set of 55 unilateral refractory TLE patients, and 39 age- and sex-matched hea
232 ad multiple myeloma and had relapsed or were refractory to 2 or more previous lines of treatment that
234 tcomes of clinical trials of cancer patients refractory to all other treatments provide support for t
236 ts with cardiogenic shock and concomitant VT refractory to antiarrhythmic drugs on mechanical support
237 characterized by severe, symptomatic ascites refractory to attempts at medical and surgical managemen
238 lator, in patients with rheumatoid arthritis refractory to biologic disease-modifying antirheumatic d
240 or and immunomodulatory drug, or were double refractory to both a proteasome inhibitor and immunomodu
244 ged 18 years or older, had cancers that were refractory to conventional treatment or for which no con
246 f pharmacologic interventions for inpatients refractory to corticosteroids, in reducing risk of colec
250 eukaemia (defined as blasts >=20% but <=30%) refractory to hypomethylating agents and with an Eastern
251 nts with high-risk myelodysplastic syndromes refractory to hypomethylating agents is less than 6 mont
254 ma IFNalpha2 levels, implying that pDCs were refractory to in vitro stimulation after IFNalpha produc
255 y, neonatal mice (Day 14 and 21) were highly refractory to induction of cell shedding after intraperi
256 found that a strain of Aedes aegypti that is refractory to infection by Dirofilaria immitis, the agen
257 mase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced.
258 arteriovenous malformations in zebrafish are refractory to inhibition of the downstream effector PI3K
259 o mometasone furoate in patients with CRSwNP refractory to intranasal corticosteroids (INCS) signific
260 t of microglia with ZL0580 renders them more refractory to latent HIV reactivation, indicating an epi
261 tion of patients, for example, those who are refractory to medical treatment or those who develop col
262 as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphoryla
265 2, which render pDCs and late DC progenitors refractory to physiological stimuli controlling pDC func
266 oT(R155Q,R271Q,R284Q) (ProT(QQQ)), a variant refractory to prothrombinase- or thrombin-mediated cleav
268 t population that would now be considered as refractory to ruxolitinib vs ruxolitinib dependent.
270 rthermore, LSCs from both AML and CML can be refractory to standard-of-care therapies and persist in
273 In contrast, we show that infected HPCs are refractory to TGF-beta signaling as another HCMV miRNA,
276 ge, one to nine therapies), of whom 40% were refractory to their previous therapy, received ibrutinib
279 t patients with COVID-19 respiratory failure refractory to traditional critical care management and o
282 ctivity." CONCLUSIONS: In adults with CRSwNP refractory to treatment with INCS alone, the addition of
284 us score of 2 or lower, and were relapsed or refractory to, or ineligible for, standard treatments.
285 herapy for select cases of severe, treatment-refractory Tourette syndrome; however, patient responses
286 ajority of intracellular protein targets are refractory toward small-molecule therapeutic engagement,
288 T) cell therapies can eliminate relapsed and refractory tumors, but the durability of antitumor activ
290 ients with cardiogenic shock and concomitant refractory ventricular arrhythmia undergoing bailout abl
291 ted resuscitation for patients with OHCA and refractory ventricular fibrillation significantly improv
292 ar fibrillation, more than half present with refractory ventricular fibrillation unresponsive to init
294 er out-of-hospital cardiac arrest from shock-refractory ventricular fibrillation/pulseless ventricula
295 ated survival in 160 consecutive adults with refractory ventricular fibrillation/ventricular tachycar
296 gastroparesis) with chronic (>12 months) of refractory vomiting (idiopathic, associated with a type
297 lectrical stimulation (GES) for treatment of refractory vomiting, associated or not with gastroparesi
300 re typically highly aggressive and treatment-refractory, yet RAS mutation itself is insufficient for