ライフサイエンスコーパス: regenerative capacity

1 that impact stem cell plasticity and impair regenerative capacity.

2 is is paralleled by a progressive decline of regenerative capacity.

3 uctal epithelium and loss of epithelial cell regenerative capacity.

4 in cells with a high proliferation rate and regenerative capacity.

5 Mammalian organs vary widely in regenerative capacity.

6 volving multiple pathways was central to PNS regenerative capacity.

7 are mechanistically linked to loss of muscle regenerative capacity.

8 entual restoration of tissue homeostasis and regenerative capacity.

9 culating PC levels, which reflect endogenous regenerative capacity.

10 romised muscle regrowth, suggesting impaired regenerative capacity.

11 he adjacent satellite cells to enhance their regenerative capacity.

12 sis, chronic inflammation and reduced muscle regenerative capacity.

13 otherapy is often associated with diminished regenerative capacity.

14 trol of the adult nervous system's intrinsic regenerative capacity.

15 implicating the thymus as having functional regenerative capacity.

16 pressor repertoires could influence species' regenerative capacity.

17 -related pathologies, including a decline in regenerative capacity.

18 tworm, Macrostomum lignano has an impressive regenerative capacity.

19 al tract (CST) neurons, display a much lower regenerative capacity.

20 ae, finding that larval tendons display high regenerative capacity.

21 apid pigment cell renewal and maintenance of regenerative capacity.

22 abolic syndrome features increased cutaneous regenerative capacity.

23 knockout mice demonstrate similar increased regenerative capacity.

24 ion was associated with impaired endothelial regenerative capacity.

25 cation and delivery of stem cells to promote regenerative capacity.

26 spinal cord regeneration because of its high regenerative capacity.

27 The liver has a strong regenerative capacity.

28 and provided a fundamental readout of their regenerative capacity.

29 otent cell population and compromising their regenerative capacity.

30 M) undergoes remodeling, and the heart loses regenerative capacity.

31 nal back to stem cells to maintain long-term regenerative capacity.

32 uminal epithelial progenitors with extensive regenerative capacity.

33 ly mechanical loading despite having minimal regenerative capacity.

34 hereas the aged rats were deficient in their regenerative capacity.

35 ily contributes to postnatal loss of cardiac regenerative capacity.

36 ns that tumor suppression is a trade-off for regenerative capacity.

37 aintaining the robustness of skeletal muscle regenerative capacity.

38 results from axonal degeneration and reduced regenerative capacity.

39 nce, satellite cell depletion and diminished regenerative capacity.

40 ics such as enhanced clonal growth and tumor regenerative capacity.

41 of the multipotent cell population and their regenerative capacity.

42 nhance resistance to cell death and increase regenerative capacity.

43 ittle is known about mechanisms that control regenerative capacity.

44 echanisms responsible for this difference in regenerative capacity.

45 nflammatory injury were compromised in their regenerative capacity.

46 have mild skeletal muscle defects and potent regenerative capacity.

47 Mature neurons have diminished intrinsic regenerative capacity.

48 ggest a role for neurogenesis in maintaining regenerative capacity.

49 The adult mammalian heart has a limited regenerative capacity.

50 l muscle, the heart possesses only a minimal regenerative capacity.

51 inimal turnover, liver cells possess immense regenerative capacity.

52 small-diameter vascular graft with tailored regenerative capacity.

53 cue of stathmin-2 expression restores axonal regenerative capacity.

54 ain might contribute to differences in their regenerative capacity.

55 and knockdown of D4ST1/Chst-14 did not alter regenerative capacity.

56 liferation of these cells and affect cardiac regenerative capacity.

57 ion of Thbs1 as a novel gene conferring high regenerative capacity.

58 f an infarcted human heart might improve its regenerative capacity.

59 f myogenic progenitors endowed with enhanced regenerative capacity.

60 s and underlying supporting cells, and lacks regenerative capacity.

61 Articular cartilage has little regenerative capacity.

62 aintained beyond embryogenesis in limbs with regenerative capacity.

63 changes in ways that broadly inhibit tissue regenerative capacity.

64 venate aged/diseased cells and improve their regenerative capacities.

65 leading to decreases in tissue function and regenerative capacity(1-3).

66 tral nervous system (CNS) loses function and regenerative capacity(5-7).

67 ostnatal skeletal muscle growth and impaired regenerative capacity after cardiotoxin-induced injury.

68 The heart has little regenerative capacity after damage, leading to much inte

69 d responses prevent the premature decline of regenerative capacity after injury.

70 adult zebrafish hearts, which have a unique regenerative capacity after injury.

71 This transient regenerative capacity, alongside their close evolutionar

72 nerate models for the uneven distribution of regenerative capacities among vertebrates.

73 reduction in cross-sectional area, impaired regenerative capacity and a significant decrease in forc

74 , that SIRT3 deficiency has no impact on the regenerative capacity and architecture of bone and soft

75 ing, whereas neonatal hearts maintained full regenerative capacity and cardiomyocyte proliferation an

76 quiescent HSC subpopulation with the highest regenerative capacity and cellular polarity, reside pred

77 dystrophy contributes substantially to lost regenerative capacity and increased fibrosis of dystroph

78 disease involving progressive loss of muscle regenerative capacity and increased fibrosis.

79 ngs identify a natural sex bias in appendage regenerative capacity and indicate an underlying regulat

80 wasting severity parallels a decline in MuSC regenerative capacity and is ameliorated histologically

81 The human heart has limited endogenous regenerative capacity and is thus an important target fo

82 rch, based on powerful genetics, high tissue regenerative capacity and low maintenance costs.

83 nohistochemistry analyses revealed increased regenerative capacity and proliferation in IGF-1 transge

84 Depending on the tissue's regenerative capacity and the quality of the inflammator

85 anipulating endogenous stem cells to enhance regenerative capacity and utilizing stem cells for drug

86 g, well-characterized development and a high regenerative capacity, and are thus an excellent model s

87 with that in P14 mice, which have lost their regenerative capacity, and identified a population of ma

88 unction, diminished pulmonary remodeling and regenerative capacity, and increased susceptibility to a

89 The improvements in I/R injury, regenerative capacity, and oncological outcomes await co

90 In mammals, hair cells lack regenerative capacity, and their death leads to permanen

91 are the only modern tetrapods that retained regenerative capacities as well as preaxial polarity in

92 Endogenous regenerative capacity, assessed as circulating progenito

93 Endogenous cardiomyocytes have regenerative capacity at birth but this capacity is lost

94 Impaired regenerative capacity, attenuated ability to respond to

95 epithelial injury and diminishing epithelial regenerative capacity because of increased cellular sene

96 characterize its biophysical properties and regenerative capacity both in vitro and in vivo.

97 ugh shorter LTL is associated with decreased regenerative capacity, both LTL and circulating progenit

98 Most adult mammalian tissues have limited regenerative capacities, but in lower vertebrates, the m

99 the muscles were of normal size, despite low regenerative capacity, but did have increased fibrosis.

100 Bone has remarkable regenerative capacity, but this ability diminishes durin

101 own of CELF or MBNL factors lead to abnormal regenerative capacities by affecting self-renewal and di

102 valves (TEHVs) with repair, remodelling and regenerative capacity can address these limitations, and

103 ity of CNS axons to regenerate, an increased regenerative capacity can be elicited following conditio

104 rganisms replace lost or damaged tissue, and regenerative capacity can vary greatly among species, ti

105 adult zebrafish is endowed with a remarkable regenerative capacity, capable of de novo cardiomyocyte

106 of cellular senescence can promote impaired regenerative capacity, chronic inflammation, and tumorig

107 This loss of regenerative capacity coincides with reduced damage-resp

108 ggest that both biological aging and reduced regenerative capacity contribute to cardiovascular event

109 s in animal species with substantial cardiac regenerative capacity dominantly comprise diploid cardio

110 e peripheral nervous system has retained its regenerative capacity, enabling severed axons to reconne

111 wever, the intestine is able to maintain the regenerative capacity even in spite of an ischemic injur

112 Using models with different regenerative capacities, followed by gain- and loss-of-f

113 The adult myocardium has a limited regenerative capacity following heart injury, and the lo

114 ifferentiation, and apoptosis and by reduced regenerative capacity following methimazole-induced neur

115 The mammalian heart has a remarkable regenerative capacity for a short period of time after b

116 lanarian flatworms with apparently limitless regenerative capacity fueled by a population of highly p

117 Reduced regenerative capacity has been proposed as a mechanism.

118 enous muscle stem cells, and impaired muscle regenerative capacity has led to the hypothesis that the

119 The source of this regenerative capacity has long been a hotly debated topi

120 llular and molecular events controlling this regenerative capacity, however, are unknown.

121 This regenerative capacity, however, is diminished as early a

122 The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cu

123 RREs are likely a crucial source of loss of regenerative capacities in vertebrates.

124 hanosensitive Hippo pathway, correlates with regenerative capacity in acceleration-sensing utricles o

125 Notably, we found that regenerative capacity in Acomys was extended to ear hole

126 onatal period, commensurate with the loss of regenerative capacity in adult mammalian hearts.

127 hus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by i

128 ith chemical modulators indicated autonomous regenerative capacity in both leader and follower cells,

129 ession in SCs and potentiate skeletal muscle regenerative capacity in chronic diseases.

130 ifferentiation are hallmarks of tissue/organ regenerative capacity in diverse species.

131 as a potential mechanism underlying loss of regenerative capacity in dystrophic muscle.

132 nous stem cell therapies designed to improve regenerative capacity in HF, especially, in HF with pres

133 cardiac failure, can be reversed by natural regenerative capacity in lower vertebrates such as zebra

134 sful axon regeneration is the poor intrinsic regenerative capacity in mature neurons in the adult mam

135 -responsive enhancers can therefore restrict regenerative capacity in maturing organisms without comp

136 vity may have potential utilities to enhance regenerative capacity in muscle diseases.

137 is involved in the onset of the loss of axon regenerative capacity in PCs.

138 Cardiac muscle cells lack regenerative capacity in postnatal mammals.

139 ak in T(3) is involved in the loss of axonal regenerative capacity in Purkinje cells (PCs).

140 5 is required in hepatocytes to enable their regenerative capacity in response to injury.

141 Retinoic acid (RA) has strong regenerative capacity in several organs, but its role in

142 de that polyploid hepatocytes have extensive regenerative capacity in situ and routinely undergo redu

143 boptimal Sox11 expression contributes to low regenerative capacity in the adult mammalian CNS.

144 s neuronal growth, contribute to the limited regenerative capacity in the central nervous system foll

145 tion, mice lacking RIP140 exhibited improved regenerative capacity in the intestine, while mice overe

146 efining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a c

147 examine the effects of exercise on cutaneous regenerative capacity in the setting of metabolic syndro

148 as muscle stem cells (MuSCs), exhibit robust regenerative capacity in vivo that is rapidly lost in cu

149 sence of ECFCs modulates MSC engraftment and regenerative capacity in vivo.

150 subclonal patterns, and vary in competitive regenerative capacity in vivo.

151 roperties of the stem cells, including their regenerative capacity in vivo.

152 ncreased expression of stem cell markers and regenerative capacity in vivo.

153 disease, suggesting that impaired endogenous regenerative capacity is associated with increased morta

154 ents a default tissue program activated when regenerative capacity is limited.

155 without scarring following MI; however, this regenerative capacity is lost by P7.

156 However, this regenerative capacity is lost by postnatal day 7 and the

157 ity and mortality worldwide, but why cardiac regenerative capacity is lost in adult humans remains an

158 on during a short postnatal period, but this regenerative capacity is lost in the adult cochlea.

159 e during the neonatal stage, this endogenous regenerative capacity is lost with age.

160 egeneration of dorsal root (DR) axons, whose regenerative capacity is particularly weak.

161 newt and axolotl) species, but notably such regenerative capacity is rare in mammals.

162 However, this regenerative capacity is reduced in muscular dystrophies

163 Regenerative capacity is robust in the neonatal mouse he

164 How to make full use of the body's innate regenerative capacity is thus a key issue.

165 g after retinal damage may unlock the latent regenerative capacity long speculated to reside in mamma

166 However, evidence suggests that their regenerative capacity may be limited in conditions of se

167 PNS axons have a better regenerative capacity, mediated in part by integrins (ex

168 This loss of regenerative capacity might be part of the general progr

169 l survival and axon regeneration in the high regenerative capacity model, further supporting a key ro

170 The adult mammalian heart has limited regenerative capacity, mostly attributable to postnatal

171 However, the endogenous regenerative capacities of different tissues are difficu

172 Aging reduces the regenerative capacities of many tissues.

173 s mitophagy, and reduces the replicative and regenerative capacities of the CPCs.

174 tion of GSK3beta with age causes the loss of regenerative capacities of the liver.

175 liver resection, overburdening metabolic and regenerative capacities of the remnant organ.

176 We developed a mouse model to assess the regenerative capacity of a critically small liver remnan

177 mportant role of the microcirculation in the regenerative capacity of a muscle even when satellite ce

178 and interstitial fibrosis, and increased the regenerative capacity of actively cycling renal tubular

179 The low regenerative capacity of adult human hearts has thus far

180 hermore, Eed regulates the proliferative and regenerative capacity of adult urothelial progenitors an

181 d HSCs, and SIRT7 up-regulation improved the regenerative capacity of aged HSCs.

182 ppressor pathways that combine to reduce the regenerative capacity of aged HSCs.

183 in can reverse these changes and restore the regenerative capacity of aged OPCs, improving remyelinat

184 cal inhibition of Notum in mice enhanced the regenerative capacity of aged stem cells and promoted re

185 Chronic infections strain the regenerative capacity of antiviral T lymphocyte populati

186 The regenerative capacity of beta-cells declines rapidly wit

187 Young rodents may not faithfully model the regenerative capacity of beta-cells in mature adult mice

188 cking IL-1 or IL-6 receptors may improve the regenerative capacity of BM cells after AMI.

189 Therefore, we analyzed the regenerative capacity of BM from CVB3-infected mice.

190 l mammals have convincingly demonstrated the regenerative capacity of cardiomyocytes.

191 icity, osteogenic potential and in vivo bone regenerative capacity of chemically modified ribonucleic

192 ed activities of different KLFs regulate the regenerative capacity of CNS neurons.

193 The regenerative capacity of CSCs in very young patients wit

194 s, it is possible that the lack of sustained regenerative capacity of cTEC progenitor cells underlies

195 ly challenging to substantially increase the regenerative capacity of damaged nerves without deleteri

196 Topical siKeap1 therapy resulted in improved regenerative capacity of diabetic wounds and accelerated

197 ut the mTOR-dependent proteins enhancing the regenerative capacity of DRG neurons remain unknown.

198 ression and differentiation can restrict the regenerative capacity of Drosophila tissues.

199 The regenerative capacity of Ercc1(-/Delta) liver after part

200 Full limb regenerative capacity of failed stumps was restored by r

201 edly enhanced the ischemic tolerance and the regenerative capacity of fatty liver.

202 nsplantation therapy relies on the life-long regenerative capacity of haematopoietic stem cells (HSCs

203 The regenerative capacity of hCPCs in young patients with no

204 e constrain the proliferation, survival, and regenerative capacity of hCPCs.

205 in folding stress (PFS(mt)), and compromised regenerative capacity of hematopoietic stem cells (HSCs)

206 th progressive bone marrow loss and impaired regenerative capacity of HSCs in competitive bone marrow

207 The regenerative capacity of human ALDH(hi) cells was assess

208 chick femur defect model to examine the bone regenerative capacity of implanted 3-dimensional (3D) sk

209 cisor stem cell niches in the embryo and the regenerative capacity of incisors in the adult.

210 a requirement for the intrinsic clock in the regenerative capacity of insulin-producing cells followi

211 In mammals, the regenerative capacity of most of the adult nervous syste

212 t PTEN/mTOR are critical for controlling the regenerative capacity of mouse corticospinal neurons.

213 The reparative and regenerative capacity of multiple mammalian tissues depe

214 ts highlight concerns on the homeostasis and regenerative capacity of muscles in these patients who o

215 Pax7 responds to NF-kappaB by impairing the regenerative capacity of myogenic cells in the muscle mi

216 tracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts.

217 The poor regenerative capacity of neural tissue highlights the ne

218 Since the regenerative capacity of normal haematopoietic stem cell

219 reasingly necessary with age to preserve the regenerative capacity of old haematopoietic stem cells.

220 ng via syndecan binding may also enhance the regenerative capacity of other growth factors.

221 However, the repair capacity of SCs and the regenerative capacity of peripheral axons are limited.

222 Cellular plasticity contributes to the regenerative capacity of plants, invertebrates, teleost

223 In this experiment, the regenerative capacity of potential tissue engineered tra

224 ir, muscle function, histopathology, and the regenerative capacity of primary muscle cells.

225 Although much is known about the regenerative capacity of retinal ganglion cells, very si

226 The regenerative capacity of skeletal muscle declines with a

227 in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhan

228 e diseases by 'seeding' injured tissues, the regenerative capacity of stem cells is influenced by reg

229 t the molecular pathways responsible for the regenerative capacity of teleosts, amphibians, and repti

230 The stability of this complex influences the regenerative capacity of the active 3+ oxidation state o

231 The regenerative capacity of the adult mammalian heart is li

232 Therefore, the regenerative capacity of the alveolar epithelium is crit

233 contribute to an age-related decline in the regenerative capacity of the bladder.

234 a barrier to axonal regrowth and limits the regenerative capacity of the CNS.

235 their differentiating descendants to ensure regenerative capacity of the flatworm via transposon sil

236 The regenerative capacity of the heart has long fascinated s

237 The regenerative capacity of the heart is markedly diminishe

238 ar matrix proteins substantially dampens the regenerative capacity of the hepatocytes, resulting in p

239 d decline in the levels of neurogenesis, the regenerative capacity of the hippocampus also subsided w

240 Enhancing the intrinsic regenerative capacity of the host by altering its enviro

241 The regenerative capacity of the injured CNS in adult mammal

242 stinal stem cells in vitro recapitulates the regenerative capacity of the intestinal epithelium(1,2).

243 Intestinal stem cells (ISCs) maintain regenerative capacity of the intestinal epithelium.

244 Given the continued regenerative capacity of the lateral line, support cells

245 The regenerative capacity of the liver is essential for reco

246 K3beta)-cyclin D3 pathway in the loss of the regenerative capacity of the liver.

247 ty in the Western world owing to the limited regenerative capacity of the mammalian cardiovascular sy

248 ) has provided an explanation for the unique regenerative capacity of the mammary gland throughout ad

249 These findings demonstrate a striking regenerative capacity of the mature CNS to support long-

250 ytes after infarction overwhelms the limited regenerative capacity of the myocardium, resulting in th

251 ged skeletal-muscle tissue is limited by the regenerative capacity of the native tissue.

252 These findings demonstrate that the profound regenerative capacity of the neonatal mammalian heart re

253 The regenerative capacity of the peripheral nervous system d

254 ies have also provided new insights into the regenerative capacity of the respiratory system.

255 essing cells are essential for the efficient regenerative capacity of the testis, and also display fa

256 One example is the deterioration of the regenerative capacity of the widespread and abundant pop

257 Moreover, the regenerative capacity of the Xenopus retina makes these

258 Here, we harnessed the endogenous regenerative capacity of the zebrafish retina to reconst

259 the twins at an early age and harnessed the regenerative capacity of their young brains.

260 The current study investigated the regenerative capacity of this cell population by compari

261 The regenerative capacity of tissues to recover from injury

262 ty to infiltrate vital brain structures, the regenerative capacity of treatment-resistant cancer stem

263 Taking advantage of the regenerative capacity of zebrafish retina, we show here

264 onishing plasticity may contribute to a high regenerative capacity on severe damage, but how plants c

265 e polyploidy was not associated with altered regenerative capacity or tissue fitness, changes in gene

266 state, accelerate regeneration, and maintain regenerative capacity over several injury-induced regene

267 However, for reasons unknown, such regenerative capacity (plasticity) is lost once supporti

268 HF patients in the attempts to augment their regenerative capacity prior to use in the clinical setti

269 This persistent regenerative capacity provides hope for neuronal replace

270 s, the ventricular epicardium has pronounced regenerative capacity, regulated by the neighbouring car

271 The molecular events underlying this regenerative capacity remain elusive.

272 echanisms that determine the tissue's cyclic regenerative capacity remain elusive.

273 reasons for this interspecies difference in regenerative capacity remain unclear.

274 ion programme that leads to the differential regenerative capacity remains elusive.

275 and whether they have stem cells and tissue-regenerative capacity remains largely unexplored.

276 ouse corticospinal neurons reactivates their regenerative capacity, resulting in significant regenera

277 nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent co

278 ng cells (SCs) in their ears retain lifelong regenerative capacities that depend on proliferation and

279 The progressive loss of endogenous regenerative capacity that accompanies mammalian aging h

280 ult zebrafish brain show vast differences in regenerative capacity that correlate with constitutive a

281 restore itself after injury yet has a modest regenerative capacity that could be enhanced by innovati

282 The liver has a high regenerative capacity that involves stem/progenitor cell

283 ransferase in hepatocytes exhibited impaired regenerative capacity that was completely rescued by adm

284 ontal basal stem cells (HBCs) and remarkable regenerative capacity, the function of human olfactory n

285 enting advanced age, infirmity, and impaired regenerative capacity, the use of Pim-1 modification sho

286 on factor that can confer an elevated innate regenerative capacity to CNS neurons.

287 Furthermore, the robust regenerative capacity to respond to both acute and susta

288 Satellite cells provide regenerative capacity to the skeletal muscle after injur

289 It possesses unique regenerative capacity upon injury.

290 lar disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that ar

291 ypic culture, we found that the loss of axon regenerative capacity was triggered prematurely by early

292 ral crest cells from other axial levels have regenerative capacity, we asked whether the cardiac neur

293 gnaling in CAST/Ei mice diminishes their CNS regenerative capacity, whereas its activation in C57BL/6

294 nce a progressive decline in homeostatic and regenerative capacities, which has been attributed to de

295 al muscle mass, skeletal muscle function and regenerative capacity, which can lead to sarcopenia and

296 Cardiac regenerative capacity widely varies across vertebrates.

297 The progressive loss of muscle regenerative capacity with age or disease results in par

298 We demonstrate that in a vertebrate of high regenerative capacity, Wnt/beta-catenin signaling contro

299 The liver is an organ with strong regenerative capacity, yet primary hepatocytes have a lo

300 gans, such as the heart and brain, with poor regenerative capacity, yet the role of TLR9 in such noni