ライフサイエンスコーパス: regulation

1 s in driving the evolution of glucocorticoid regulation.

2 represent maps of potential transcriptional regulation.

3 raneless nuclear organelles involved in gene regulation.

4 n and outlines current models of germination regulation.

5 al molecules and mechanisms involved in cell regulation.

6 a, an index of negative feedback and emotion regulation.

7 key signaling pathways in NFKBIZ/IkappaBzeta regulation.

8 motifs that can be targeted for therapeutic regulation.

9 in contributing to Earth surface temperature regulation.

10 oles include pathogenesis response (PR) gene regulation.

11 discuss the biological significance of such regulation.

12 oglycan N-deacetylation and their respective regulation.

13 of allergen-induced Th2 responses via cross-regulation.

14 nderstanding of PLB-mediated SERCA transport regulation.

15 genomic intervals in terms of transcription regulation.

16 mprehensive understanding of SWI/SNF complex regulation.

17 ion channel implicated in K(+) uptake and pH regulation.

18 is an important focal point in systemic iron regulation.

19 esponsiveness contributing to blood pressure regulation.

20 ysiological function, such as blood pressure regulation.

21 owed dye levels in conformity with Brazilian regulations.

22 Research into hippocampal self-regulation abilities may help determine the clinical sig

23 yme involved in DNA repair and transcription regulation, among other processes.

24 imescales that are similar to canonical gene regulation and can respond to rapid environmental change

25 tabolome, especially lipidome, reflects gene regulation and dietary exposures, heralding the developm

26 istinct differences in intracellular calcium regulation and excitation-contraction (EC) coupling.

27 he current study is aimed to investigate the regulation and function of PDE10A in cardiac cells and i

28 nd discusses several emerging models for the regulation and function of this adhesin.

29 de the cell nucleus plays a key role in gene regulation and genome replication, as well as maintainin

30 regulation, thereby improving cardiovascular regulation and immunity long after SCI.SIGNIFICANCE STAT

31 We argue that regulation and mitigation should always be developed by

32 investigated The present study assessed CBF regulation and neurovascular coupling during submaximal

33 des resources for functional studies of gene regulation and QDR molecular mechanisms across the Penta

34 hey play an important role in blood pressure regulation and reducing the risk of heart failure.

35 ich in turn contributes to perturbed emotion regulation and subsequent risk for depression.

36 ar mechanisms underlying hyaluronan and HAS2 regulation and the role of soluble proteoglycan in affec

37 rst systematic investigation of TF and miRNA regulation and their co-regulation in two major TGCT sub

38 nd has been implicated in both gene-specific regulation and transcription through nucleosomes.

39 However, information of their expression, regulation and transcriptional targets in human PH and t

40 the primary effects of lockdowns, government regulations and patient deferrals, and the secondary eco

41 e the importance of the latter in signaling, regulation, and bias.

42 sses, including cell division, transcription regulation, and cell signaling.

43 provide a rich resource for studying Shank3 regulation, and demonstrate the feasibility of this appr

44 resilience systems implicated in behavioral regulation, and may inform novel strategies for therapeu

45 a direct interference or indirectly via gene regulation, and may suggest evolutionary outcomes of ret

46 ts on social- and affective behavior, stress regulation, and neural activity.

47 e-wide histone modification, transcriptional regulation, and RNA processing, and thereby mediating de

48 with recommendations for research, policies, regulations, and practices needed to ensure optimal wate

49 xtracellular matrix (ECM) and DNA epigenetic regulation are critical for maintaining stem cell phenot

50 eceptor (PRC) membrane organization and gene regulation are critical to understanding sight and retin

51 understood about how such networks of cross-regulation are established and what the functional conse

52 ve monitoring programs and subsequent strict regulations are strongly required.

53 d provide insight into core elements of SINE regulation, as well as disregulation of SINE elements as

54 o analyze transcriptome data, predict causal regulations, assess network topology and identify key re

55 Mechanisms of regulation at each step, from initiation to elongation d

56 the foundation for dissecting photosynthetic regulation at the level of single protein complexes with

57 ic di-GMP, which provides evidence for cross-regulation between different CDN pathways.

58 complexes are necessary for transcriptional regulation but through different mechanisms.

59 o-sensing is achieved in yeast GAL metabolic regulation, but also elucidated design principles for ra

60 FcepsilonRI regulation by 1,25(OH)(2)-D(3) was independent of matura

61 channel state and observation of allosteric regulation by agonist binding with MD remains difficult

62 We analyzed Notch regulation by examining expression profiles (by quantita

63 overs previously unknown mechanisms of Hippo regulation by heat shock, as well as physiological funct

64 In vitro study confirmed that VPS35 up-regulation by reducing total levels of APP and results i

65 metric that accurately predicts mTORC1/LARP1 regulation called a TOPscore.

66 (V-type proton ATPase), and inorganic carbon regulation (carbonic anhydrase).

67 d gene expression across the brain's emotion regulation circuitry may underlie individual differences

68 in cells and that several together can exert regulation comparable to GCAUG in a trichromatic splicin

69 ant but limited effect on histone transcript regulation, consistent with multiple mechanisms acting t

70 biosynthesis of these lipoproteins, and its regulation determines fat mobilization to different tiss

71 ibute to the overall septal PG synthesis and regulation during cell division.

72 the isolated influence of temperature on CBF regulation during exercise has not been investigated The

73 a graphical user interface and can mine gene regulations, either by applying a dynamic Bayesian netwo

74 ultrasensitive form of polymerization-based regulation employed by human CTP synthase 2 (CTPS2).

75 on exceeded the maximum level established by Regulation EU/10/2011 (10 ng g(-1)).

76 o map the relevant lysines on actin for INF2 regulation, focusing on K50, K61, and K328.

77 is known about the development of aggression regulation following social feedback during childhood, w

78 changes in cardiac myocyte Ca(2+) and Na(+) regulation from the formation of compensated hypertrophy

79 Epigenetic regulation has a profound influence on stem cell fate du

80 Such cross-regulation has been proposed to be important to control

81 Insights into pyrin regulation have come from studies of several Yersinia ef

82 tion of different upstream components in its regulation have not been well characterized.

83 h motifs are prone to impact transcriptional regulation if mutated.

84 her and how CRC contributes to transcription regulation in Ewing sarcoma is unknown.

85 ic subsystems are involved in cardiovascular regulation in humans.

86 tions between four key TFs contribute to cis-regulation in mouse ESCs, we assayed two massively paral

87 epression imaging phenotypes track gene down-regulation in postmortem cortical samples of patients wi

88 ese genes largely retained features of their regulation in space and time.

89 ore treatment initiation or dynamic integrin regulation in the early course of treatment seem to be p

90 entify a pathway of estrogen-mediated immune regulation in the intestine, whereby homeostatic express

91 ights into the origin and evolution of redox regulation in the protein kinase superfamily and may ope

92 urthermore, our work illustrates that RanGTP regulation in the spindle is not simply a switch, but ra

93 tion of TF and miRNA regulation and their co-regulation in two major TGCT subtypes.

94 at Vgf nerve growth factor inducible gene up-regulation is a common transcriptional stress response i

95 ation of 2OGDDs in normal cells and how that regulation is corrupted in cancer.

96 Mitochondrial morphology and activity regulation is essential for cell survival, differentiati

97 lysis of class I RNRs suggests that activity regulation is not ancestral but was gained after the fir

98 local and systemic inflammation, its overall regulation is still not fully understood.

99 site (here named EACBE) in dynamic chromatin regulation is unknown.

100 Though LSD1 is implicated in heterochromatin regulation, its function is inconsistent across differen

101 n 2018, JUUL entered the UK market, where EU regulations limit liquid nicotine concentration to 20 mg

102 This supports the hypothesis that efferent regulation may be a biological control parameter for tun

103 ulating MEIS1 expression, and that this down-regulation may contribute to MYC-driven development and

104 its functional site, is a common allosteric regulation mechanism.

105 une responses rely on rapid and precise gene regulation mediated by accessibility of regulatory regio

106 PARP family members and ADPRylation in gene regulation, mRNA processing, and protein abundance.

107 CCCs play roles in cellular volume regulation, neural development and function, audition, r

108 determine whether cell-cycle-dependent gene regulation occurs in mycobacteria, we characterized the

109 This regulation occurs in the context of large genomes conden

110 We propose a model that differential regulation of 12-OPDA and JA in response to T. virens co

111 s placed on analyzing the precise structural regulation of 2D CCFs.

112 Herein, we review the regulation of 2OGDDs in normal cells and how that regula

113 ly, our findings shed important light on the regulation of a novel PRMT5/YBX1/NF-kappaB axis through

114 activity of Lpg2603 reveal a unique mode of regulation of a protein kinase, provide the first exampl

115 in-like peptides have been implicated in the regulation of a wide range of social behaviors across ta

116 up-regulation of nutrient transporters, down-regulation of adhesion molecules and tumor suppressing p

117 Our understanding of the molecular regulation of aging and age-related diseases is still in

118 ts demonstrate an important role of NBCn1 in regulation of alcohol consumption and sensitivity to alc

119 nal Seabed Authority, whose mandates include regulation of all mineral-related activities in internat

120 2 mutants display increased autophagy and up-regulation of an ER stress-responsive chaperone.

121 Aspergillus fumigatus challenge through the regulation of antifungal leukocyte responses in mice.

122 One of the brainstem nuclei involved in the regulation of anxiety is the dorsal raphe, which contain

123 vestigated DDX3-mediated posttranscriptional regulation of AR mRNA (messenger RNA) in CRPC.

124 Both receptors are related to the regulation of arbuscular mycorrhiza (AM) formation and a

125 Further, down-regulation of AtPAM16L affected seed germination, even i

126 Transcriptional regulation of AZ development appears to be extensively r

127 This study provides evidence for FA-mediated regulation of BCAA-catabolizing enzymes and BCKA content

128 GPRC6A's unique regulation of beta-cell, skeletal muscle and hepatic fun

129 , neural development and function, audition, regulation of blood pressure, and renal function.

130 a mechanistic explanation for the acute O(2) regulation of breathing, reveal an unanticipated role of

131 ze both the primary metabolism and metabolic regulation of C. acetobutylicum.

132 ranscription factor Mrr1, best known for its regulation of Candida azole resistance genes such as MDR

133 We demonstrated that negative regulation of CCL2 production by GPBAR1 agonism was prom

134 Balanced regulation of cell death and inflammatory immune respons

135 ystem-the complosome-and its key role in the regulation of cell metabolic pathways that underly norma

136 er of critical cellular functions, including regulation of cell shape and polarity, cytokinesis, cell

137 nd respiratory diseases and were involved in regulation of cellular development, function, growth, an

138 reviously unrecognized mechanism involved in regulation of cellular iron homeostasis.

139 gether, these studies implicate Gal-9 in the regulation of cellular proliferation and epithelial rest

140 n, our results reveal distinct PKC-dependent regulation of CF transdifferentiation and proliferation

141 ell as up-regulation of MHC class I and down-regulation of checkpoint regulator PD-L1 on the cancer c

142 We show that permissive epigenetic regulation of cldn5 expression and low endothelium expre

143 al properties of cells can contribute to the regulation of collective cell migration.

144 lect acute differences in activity-dependent regulation of critical genes is currently unknown.

145 down-regulation of E-cadherin (CDH1) and up-regulation of CXCL12 in endometriosis tissues.

146 system, with emphasis on recent work on the regulation of cytokine production and proliferation.

147 Interestingly, the feedback regulation of DBL-1/BMP signaling by collagens is likely

148 to top-down, bottom-up and density-dependent regulation of demographic rates in an imperilled mesopre

149 Possible mechanisms for such differential regulation of different subsets of p53 target genes may

150 signaling drives a number of cancers through regulation of diverse downstream pathways.

151 equires GRSF1-dependent post-transcriptional regulation of Dux mRNA.

152 IHC confirmed the down-regulation of E-cadherin (CDH1) and up-regulation of CXC

153 results show a novel role for MondoA in the regulation of early vertebrate development, connecting g

154 adipocytes) that play a crucial role in the regulation of energy metabolism and systemic glucose hom

155 This contributes to sex-specific regulation of excitability, [Ca(2+)](i), and myogenic to

156 cific protein unveil key aspects of negative regulation of exocytosis.

157 nal and lipidomic analyses further link AMPK regulation of ferroptosis to AMPK-mediated phosphorylati

158 ry complexity underlying the spationumerical regulation of flagellar biogenesis and implies that flag

159 Moreover, there is a strict physiological regulation of forest transpiration.

160 he alpha2 subunit play a role in the dynamic regulation of GABA(A)R accumulation at inhibitory synaps

161 alpha abrogated the endorepellin-mediated up-regulation of GADD45alpha, the ultimate effector protein

162 associations near genes involved with global regulation of gene expression (SATB1) and the estrogen r

163 HIF1alpha- and HIF2alpha-mediated regulation of gene expression did not explain most of th

164 The regulation of gene expression is a result of a complex i

165 The regulation of gene expression is central to many biologi

166 nuclear space has been extensively linked to regulation of gene expression, but the mechanisms behind

167 vergence of oxygen signaling with epigenetic regulation of gene expression.

168 ngation are primary points of control in the regulation of gene expression.

169 onnected to other cellular processes such as regulation of gene expression.

170 RNAs mediate cellular processes such as the regulation of gene transcription and the enhancement or

171 Epigenetic regulation of gene transcription has been shown to coord

172 r, the endogenous role that PC2 plays in the regulation of general cellular homeostasis remains uncle

173 ctor that reflected the degree of up or down regulation of genes encoding a reaction, identified 102

174 on of SE interactions that underlie hormonal regulation of genes in uterine tissue and optimal develo

175 involved in mitotic cell division but an up-regulation of genes involved in apoptosis and stress res

176 t Bccip deletion caused an overwhelming down-regulation of genes involved in mitotic cell division bu

177 protein, was found to be the transcriptional regulation of genes responsible for cell wall synthesis,

178 (IIS) pathway plays an essential role in the regulation of glucose and lipid homeostasis.

179 or NMD that contributes to the UPF2-mediated regulation of GLUR1 by limiting total GLUR1 levels.

180 HSCs during chronic liver injury in vivo via regulation of HSC survival and migration and affect the

181 last 50 years, most studies have focused on regulation of Hsp70 activities by altered transcription,

182 enes include antimicrobial humoral response, regulation of humoral response and various metabolic pro

183 .5(+/)) and mice in which the cAMP-dependent regulation of hyperpolarization-activated f-(HCN4) chann

184 In this study, we investigated the regulation of IL-3R expression on human Th cells and als

185 resistance to selected pathogens and in the regulation of inflammation(1-3).

186 investigate this matter through the temporal regulation of initiation in a living coordination-insert

187 uidance cues may yield new insights into the regulation of innate immunity.

188 ur results highlighted an enrichment of the "Regulation of Insulin-like Growth Factor (IGF) transport

189 Precise regulation of integrin-mediated adhesion is important fo

190 hages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as

191 We propose that dynamic regulation of ion transport and metabolic plasticity are

192 nce of beta-cell identity through fine-tuned regulation of key transcription factors ensures beta-cel

193 se properties were dependent upon epigenetic regulation of key VSMC differentiation genes; notably, K

194 e our understanding of the role of lipids in regulation of lifespan and healthspan additional studies

195 tors AP-1 and NF-kappaB, leading to the down-regulation of LINE-1 promoter activity.

196 recognized role of host IL-6 response in the regulation of lung inflammation during AA and the contro

197 ytic and signaling functions require precise regulation of lysosomal cholesterol content.

198 genetic mutations that may function through regulation of m7G methylation.

199 tance to reactive oxygen species through the regulation of manganese transport.

200 Circadian regulation of metabolism is largely driven by rhythmic t

201 tion plays a major role in the physiological regulation of metabolism.

202 senting dendritic cells (DCs), as well as up-regulation of MHC class I and down-regulation of checkpo

203 While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the

204 IL-4Ralpha regulation of MMC9s is in part BATF-dependent and occurs

205 ur results reveal a surprising bidirectional regulation of molecular signaling between sensory neuron

206 internode growth, providing insight into the regulation of monocot stem development.

207 These data suggest a broad regulation of motor behavior by DA neurons within multip

208 odate these environmental changes, including regulation of mRNAs that require extensive uridine inser

209 CARP-1 is a part of the NF-kappaB proteome, regulation of NF-kappaB signaling by CARP-1 and the mole

210 provides a mechanism for the activation and regulation of NK cells by Ebola glycoprotein.TRIAL REGIS

211 pplication of synthetic riboswitches for the regulation of nuclear-encoded genes in planta remains to

212 alloproteinases (MMPs) are implicated in the regulation of numerous physiological processes, evidence

213 zed by common biological themes including up-regulation of nutrient transporters, down-regulation of

214 er drugs bortezomib and carfilzomib in their regulation of OAT1 expression and transport activity.

215 s/Raf/MAPK signaling pathway and involved in regulation of organogenesis, differentiation, cell migra

216 ere, we describe a function for NEK10 in the regulation of p53 transcriptional activity through tyros

217 een the reward and circadian pathways in the regulation of pathological calorie consumption.

218 logy and pathology on the microenvironmental regulation of PCa cell behaviour.

219 ric LIN phenomenon but also for the temporal regulation of phage lysis in general.

220 tructure raises intriguing possibilities for regulation of photosynthetic function.

221 have been co-opted during evolution into the regulation of plant growth, development and differentiat

222 role of CCC1 ion transporter activity in the regulation of plant immunity is corroborated by experime

223 mainly physical origin of fragmentation and regulation of platelet size in flow-accelerated platelet

224 ons, will allow a careful examination of the regulation of pLGICs at a molecular level, expanding our

225 g and osteoclast fusion, potentially via its regulation of Pmepa1 expression.

226 t microRNAs might play a significant role in regulation of PRF expression.

227 nd patterning is executed through a balanced regulation of progenitor self-renewal and differentiatio

228 Cellular regulation of protein functions involves differential ge

229 This methodology enables spatial regulation of protein synthesis, and deciphering, recons

230 netic changes, protein aggregation, and down-regulation of quality control mechanisms are all hallmar

231 als unique histone codes for transcriptional regulation of reported CIGs, and utilizes these codes to

232 s of RhoA have been identified, the temporal regulation of RhoA and the coordination of different ups

233 ulation of auxin signaling as well as in the regulation of root morphogenesis under both normal and s

234 rate a requirement for dnmt1 activity in the regulation of RSC proliferation, gene expression and in

235 a(2+) alternans, making Ca(2+)-CaM dependent regulation of RyR2 an important therapeutic target for c

236 histone methylation plays critical roles in regulation of seed dormancy during seed germination and

237 Thus, the dynamic regulation of SFs promotes BB connections and cortical i

238 will help researchers better understand the regulation of shedding and may aid in the development of

239 at SHR-SCR protein complex stoichiometry and regulation of SHR transcription modulate the division ti

240 photosynthesis and leaf and root anatomy, up-regulation of Si channel and transporter genes, ascorbat

241 Moreover, the up-regulation of specific transketolase genes (tktAB) sugge

242 ) T cells as potential mechanisms for LXA(4) regulation of T cell effector function and trafficking.

243 findings indicate that post-transcriptional regulation of tankyrase serves as a ligand-independent d

244 Significant down-regulation of terminal differentiation (FLG and FLG2), l

245 an epigenetic mechanism of action of NONO in regulation of TET1-targeted neuronal genes, offering new

246 ations, we successfully demonstrate that the regulation of the assembly pathways through seeded growt

247 nal effects of methionine oxidation on CaM's regulation of the calcium release channel, ryanodine rec

248 on the CLEAR-CLIP analysis, we found a novel regulation of the circadian rhythm and sleep by the miR-

249 nd interesting questions on the function and regulation of the E/I balance.

250 The EACBE is required for long-distance regulation of the Ealpha on the proximal Valpha genes, a

251 Although regulation of the epigenome plays a key role in shaping

252 The regulation of the expression of these genes is ablated b

253 imetic that activates cell proliferation via regulation of the Hippo pathway, highlighting the potent

254 centration in the colon correlated with down-regulation of the host SLC7A2 transporter.

255 is kinase in macrophages with studies of its regulation of the NLR family, pyrin domain-containing 3

256 perm chemotaxis studies, the composition and regulation of the signalling network underlying the cyto

257 rations in brain circuitry implicated in the regulation of the stress response are associated with re

258 he extracellular domain (ECD) and allosteric regulation of the transmembrane domain (TMD) from synerg

259 the physiological significance for circadian regulation of these processes (ie, the good); (2) the pa

260 the molecular mechanisms associated with the regulation of these traits by Q, especially for the stru

261 hat these neurons play a pivotal role in the regulation of thirst stimulated by NaCl and AngII.

262 This work shows that regulation of tissue-specific splicing can influence FXR

263 expression patterns, functions, and Hox gene regulation of trachealess (trh), ventral veinless (vvl),

264 However, the importance and regulation of TRIM21 during bacterial infection remains

265 r results unveil that the histotype-specific regulation of tumor fibrosis in lung cancer is mediated

266 ance of phospholemman phosphorylation in the regulation of vascular tone and BP and suggest a novel m

267 ic mesenchymal features show simultaneous up-regulation of vimentin and high basal Rac1-GTP levels wh

268 daptive process that has locked together the regulation of water and carbon fluxes in vascular plants

269 l modeling demonstrates that the NAC-induced regulations of SRP activity are essential for the fideli

270 rs of CRMs, TF activities, and corresponding regulation on gene transcription, which it models as a s

271 Molecular regulation, on the other hand, involves tuning an optima

272 ly, very little is known about mechanisms of regulation or signaling of the longer isoform.

273 Coupled with eIF4E translational regulation, our study highlights an important mechanism

274 = 41) and explicit (N studies = 19) emotion regulation processes.

275 This study confirmed that a self-regulation programme could effectively improve self-care

276 Appropriate developmental gene regulation relies on the capacity of gene promoters to i

277 le in memory formation, yet its role in mood regulation remains controversial.

278 nsducing systems are necessary for metabolic regulation, resistance to antibiotics and antimicrobials

279 This regulation results from unique properties of proteins un

280 mic and functional analyses establish SERBP1 regulation role in metabolic routes preferentially used

281 errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and deregu

282 iscuss different levels of pre-mRNA splicing regulation such as post-translational modifications and

283 pression of transgenes, we developed a miRNA regulation system that is activated only when HSPCs are

284 ither on the intervention nor on the emotion regulation task.

285 supportive, physiologic milieu and systemic regulation that resulted in functional and histological

286 Negative feedback regulation, that is the ability of a gene to repress its

287 important roles at almost all levels of gene regulation through interacting with RNAs, and contribute

288 emphasize the importance of gene expression regulation through the dynamic AGO2-RNA association for

289 ng the importance of inflammation and immune regulation through the IL18-IL18RAP axis and antigen pre

290 tion functions as an additional mode of Gle1 regulation to ensure proper mRNA export and translation.

291 stood how plants control light-dependent FAS regulation to meet the cellular demand for acyl chains.

292 and SOX2 during cell-cycle and self-renewal regulation to restrain tumorigenesis.

293 the transcription program through chromatin regulation to rewire cellular metabolism.

294 Changes in gene regulation underlie much of phenotypic evolution(1).

295 subcutaneous adipose tissue transcriptional regulation using omic-scale data from ~3000 geographical

296 t (calmodulin, calcium-binding proteins), pH regulation (V-type proton ATPase), and inorganic carbon

297 Considering work-safety regulations, we will identify immanent noise patterns du

298 that mimics the physical layout of splicing regulation where the chromatin context progressively cha

299 ntrations and considers metabolite-dependent regulation while still retaining many computational adva

300 Linking ex vivo gene down-regulation with in vivo neuroimaging, we find that trans