ライフサイエンスコーパス: regulation of apoptosis

1 nd Rybp can encode opposing functions in the regulation of apoptosis.

2 ing energy production, calcium buffering and regulation of apoptosis.

3 tory protein-1 (CARP-1), may function in the regulation of apoptosis.

4 ies unveiled novel functions of TIMPs in the regulation of apoptosis.

5 t and that ppGaNTases may play a role in the regulation of apoptosis.

6 constitute a critical control point for the regulation of apoptosis.

7 s that has been implicated previously in the regulation of apoptosis.

8 nonhomotypic death-fold interactions in the regulation of apoptosis.

9 in (IAP) family, plays a crucial role in the regulation of apoptosis.

10 eviously unappreciated role for IRF-2 in the regulation of apoptosis.

11 Bax play central and redundant roles in the regulation of apoptosis.

12 kes these proteins exquisitely suited to the regulation of apoptosis.

13 thway by MEKK1 is independent of its role in regulation of apoptosis.

14 ransduction pathway similar to that used for regulation of apoptosis.

15 uggesting multiple roles for Bcl-X(L) in the regulation of apoptosis.

16 ic product of osteoblasts with a role in the regulation of apoptosis.

17 for the nuclear c-Abl tyrosine kinase in the regulation of apoptosis.

18 dhesion, induction of pre-mRNA splicing, and regulation of apoptosis.

19 suggesting a possible role for MALT1 in the regulation of apoptosis.

20 Heretofore, all known DEDs functioned in the regulation of apoptosis.

21 se C (PKC) family has been implicated in the regulation of apoptosis.

22 activity is mechanistically involved in the regulation of apoptosis.

23 x-sensitive signaling pathway coupled to the regulation of apoptosis.

24 2 family of proteins plays a key role in the regulation of apoptosis.

25 apoptosis and that STAT5 participates in the regulation of apoptosis.

26 of the Bcl-2 family may be required for the regulation of apoptosis.

27 mily of proteins plays a significant role in regulation of apoptosis.

28 the Bcl-2 family that play key roles in the regulation of apoptosis.

29 des a unique model for studying the hormonal regulation of apoptosis.

30 cl-2, Bcl-XL, and Bax) play key roles in the regulation of apoptosis.

31 BRCA1 genes may play a critical role in the regulation of apoptosis.

32 eath suggests a role for this protein in the regulation of apoptosis.

33 play an evolutionarily conserved role in the regulation of apoptosis.

34 oligomeric forms, play a central role in the regulation of apoptosis.

35 with other Bcl-2 proteins necessary for the regulation of apoptosis.

36 d TAp73 in the induction of Noxa and Bim and regulation of apoptosis.

37 CS3) genes, which have opposing roles in the regulation of apoptosis.

38 lism and nutrient uptake, antioxidation, and regulation of apoptosis.

39 to neuronal stress responses, including the regulation of apoptosis.

40 -2 protein family play a central role in the regulation of apoptosis.

41 of acetylated p53 transcription-independent regulation of apoptosis.

42 ane-integrated forms that are central to the regulation of apoptosis.

43 as long been postulated to contribute to the regulation of apoptosis.

44 ting this balance through cell-type-specific regulation of apoptosis.

45 ion and division play important roles in the regulation of apoptosis.

46 nd IFN-gamma-activated IRF8 were involved in regulation of apoptosis.

47 and E2F-like proteins in apoptosis, and the regulation of apoptosis.

48 y members, including BAD, are not limited to regulation of apoptosis.

49 h is inactivated by AKT, for its role in the regulation of apoptosis.

50 hypothesized that MAGE-A4 is involved in the regulation of apoptosis.

51 way in Xenopus and, in other systems, in the regulation of apoptosis.

52 ding, insertion, and permeabilization to the regulation of apoptosis.

53 , which have been implicated in the negative regulation of apoptosis.

54 factor receptor signaling and is key for the regulation of apoptosis.

55 ks are integrated at the mitochondria in the regulation of apoptosis.

56 NF-kappaB has been implicated in the regulation of apoptosis, a key mechanism of normal and m

57 The Akt signaling pathway contributes to regulation of apoptosis after a variety of cell death st

58 The Bad signaling pathway contributes to the regulation of apoptosis after a variety of cell death st

59 also show increased growth inhibition and up-regulation of apoptosis after exposure to MK886 alone, o

60 re regulated by both treatments suggest down-regulation of apoptosis, altered signal transduction, an

61 of the Bcl-2 family that are involved in the regulation of apoptosis and analyzed DNA fragmentation a

62 equired for hormone-mediated transcriptional regulation of apoptosis and autophagy genes during ecdys

63 However, PGC1beta overexpression triggers up-regulation of apoptosis and autophagy genes, resulting i

64 f BIRC6 in stimulated monocytes, implicating regulation of apoptosis and autophagy in the pathogenesi

65 ovel link between HMGB1 and p53 in the cross-regulation of apoptosis and autophagy in the setting of

66 uggest that SHP-1 plays an important role in regulation of apoptosis and cell cycle arrest after a ga

67 s not well characterized but may involve the regulation of apoptosis and cell cycle progression.

68 ce of epithelia, immunity, and fertility and regulation of apoptosis and cell differentiation.

69 odulation of DAPK activities is critical for regulation of apoptosis and cellular homeostasis.

70 Thus, our data demonstrate CD154-dependent regulation of apoptosis and DC homeostasis in mice with

71 We used BH3 profiling to query mitochondrial regulation of apoptosis and defined a transition from un

72 rent aspects of tumor biology, including (i) regulation of apoptosis and differentiation, (ii) promot

73 he interaction between genes involved in the regulation of apoptosis and environmental factors such a

74 receptor domains and protein kinases in the regulation of apoptosis and hematopoietic precursor cell

75 transcription factors play a key role in the regulation of apoptosis and in tumorigenesis by controll

76 a CARD (ASC) and NLRP3 play key roles in the regulation of apoptosis and inflammation through self-as

77 Various roles, including the regulation of apoptosis and innate immune responses to v

78 rm labor in mice and its relationship to the regulation of apoptosis and innate immune responses.

79 TMS1 functions in the regulation of apoptosis and is frequently methylated and

80 Btk-mediated regulation of apoptosis and JNK activity was confirmed b

81 een FADD and RIP1, which is critical for the regulation of apoptosis and necrosis during embryogenesi

82 Several studies have implicated RIP3 in the regulation of apoptosis and NF-kappa B signaling, but wh

83 sses, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuclear transcription.

84 onounced defects in organogenesis and in the regulation of apoptosis and proliferation during mammali

85 Mir21 knockout abolished circadian regulation of apoptosis and reduced necrotic core size b

86 GSK-3 thus plays a critical role in regulation of apoptosis and represents a key downstream

87 for further elucidating the role of XIAP in regulation of apoptosis and represents a promising lead

88 ion of mutant protein, protein activity, and regulation of apoptosis and senescence in lymphoblasts d

89 propose that N5 protein plays a role in the regulation of apoptosis and that Rb directly coordinates

90 tative transcriptional activator involved in regulation of apoptosis and the cell cycle.

91 e insights into the function of HtrA2 in the regulation of apoptosis and the oncogenic activities of

92 ling an unexpected role for integrins in the regulation of apoptosis and tissue remodeling.

93 es involved in cell cycle-arrested, negative regulation of apoptosis, and DNA damage response were up

94 tegies, including decoy chemokine receptors, regulation of apoptosis, and evasion of complement-media

95 tic pathways converge on the transcriptional regulation of apoptosis, and genes such as Cdkn1a, sugge

96 enriched for protein trafficking, splicing, regulation of apoptosis, and prevention of amyloid cleav

97 or-like activity in acute leukemia cells via regulation of apoptosis, and that miR-27a and 14-3-3thet

98 cl-2 and mdm2 genes that are involved in the regulation of apoptosis, and the mitogen-activated prote

99 2 and mdm-2 genes, which are involved in the regulation of apoptosis, and the mitogen-activated prote

100 Protein Metabolic Process, Protein Folding, Regulation of Apoptosis, and Transporter Activity.

101 se in self-renewal and tumorigenicty, and up-regulation of apoptosis- and differentiation-related gen

102 tion of genes strongly enriched for negative regulation of apoptosis, angiogenesis, and metastasis.

103 Because NF-kappa B plays a major role in regulation of apoptosis, angiogenesis, carcinogenesis, a

104 not known, although the role of NF-kappaB in regulation of apoptosis, angiogenesis, carcinogenesis, a

105 es were downregulated, suggesting a biphasic regulation of apoptosis: antiapoptotic state early and m

106 equently, balanced energy metabolism and the regulation of apoptosis are critical for the development

107 Because defects in regulation of apoptosis are involved in the development

108 er, the molecular mechanisms underlying IRF8 regulation of apoptosis are still not fully understood.

109 cell signaling lipid that is involved in the regulation of apoptosis as well as cell polarity.

110 Many oncogenes are implicated in the regulation of apoptosis as well as in control of the cel

111 targeting of the NAF-1-Bcl-2 complex in the regulation of apoptosis/autophagy in cancer biology.

112 uring catagen, as well as differences in the regulation of apoptosis between distinct HF cell populat

113 Multiple other pathways, involving regulation of apoptosis, bone and cartilage formation, a

114 IRP, is probably not involved in the general regulation of apoptosis but is required for embryonic cy

115 Nitric oxide (NO) plays a key role in the regulation of apoptosis, but its role in Fas-induced cel

116 lian proteins are intimately involved in the regulation of apoptosis, but, their precise mechanism of

117 Regulation of apoptosis by A1-a may be an important proi

118 e contributory mechanism in this role is the regulation of apoptosis by butyrate.

119 This study provides new insights into the regulation of apoptosis by cross-tissue communication, a

120 s a novel, simple approach for investigating regulation of apoptosis by cytochrome c and provides a m

121 atial explanation of the previously reported regulation of apoptosis by Gene 33 via the c-Abl/p73 pat

122 y by GSK-3 is an important mechanism for the regulation of apoptosis by growth factors, PI3K, and AKT

123 he mechanism of action for Smac mimetics and regulation of apoptosis by inhibitor of apoptosis protei

124 Regulation of apoptosis by mitochondrial release of cyto

125 We suggest that the regulation of apoptosis by Six and Eya family members is

126 y, we examined the involvement of p21 in the regulation of apoptosis by suppressing its induction in

127 Thus, the data indicate that the regulation of apoptosis by T is one mechanism involved i

128 nse to TRAIL sheds new light on the negative regulation of apoptosis by the autophagic process and by

129 that might explain these differences in the regulation of apoptosis, Ca2+ homeostasis was analyzed a

130 umor suppressor genes, and genes involved in regulation of apoptosis, cell cycle, and cell differenti

131 hat both p73 and p63 play important roles in regulation of apoptosis, cell differentiation, and thera

132 Caspases play a critical role in regulation of apoptosis, cell differentiation, inflammat

133 ral mechanisms, but are also involved in the regulation of apoptosis, cell growth and differentiation

134 HAX1 protein is involved in the regulation of apoptosis, cell motility and calcium homeo

135 ized roles for TNF in macrophage activation; regulation of apoptosis; chemokine and cytokine producti

136 s, suggesting different mechanisms of TIMP-1 regulation of apoptosis depending on cell types.

137 mor protein(TCTP) has been implicated in the regulation of apoptosis, DNA repair and drug resistance.

138 TAK1/MKK/p38 signaling mediated opposing regulation of apoptosis during infection versus normal t

139 s, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and

140 paf1, demonstrating a role for miRNAs in the regulation of apoptosis during normal development.

141 rences in the control of anchorage-dependent regulation of apoptosis exist in melanocytes and melanom

142 cesses, including transcriptional silencing, regulation of apoptosis, fat mobilization, and lifespan

143 regulation of keratinocyte homeostasis, and regulation of apoptosis following UV radiation.

144 Mitochondrial regulation of apoptosis further downstream of Bax was in

145 of insulin-like growth factors (IGFs) in the regulation of apoptosis has been suggested, yet their im

146 not fully understood, a role of SFRP1 in the regulation of apoptosis has been suggested.

147 the specific role of each MMR protein in the regulation of apoptosis has not been determined.

148 ensively studied, the role of survivin-2B in regulation of apoptosis has not been well defined.

149 Recently, mitochondrial roles in regulation of apoptosis have been discovered in many cel

150 mbinant cytokine therapy, gene delivery, and regulation of apoptosis, have been explored and offer cl

151 Transcriptional regulation of apoptosis, however, is incompletely unders

152 g the importance of cell partitioning in the regulation of apoptosis, immunofluorescence, and subcell

153 signaling cascade has been implicated in the regulation of apoptosis in a variety of mammalian cell t

154 We show that SGK is involved in the regulation of apoptosis in breast cancer cells by modula

155 ical mitochondrial protein implicated in the regulation of apoptosis in cancer cells.

156 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia

157 Our results reveal a novel regulation of apoptosis in development and new insights

158 (et) and showed that it is required for the regulation of apoptosis in Drosophila.

159 Here we examine the role of integrins in the regulation of apoptosis in gastrointestinal epithelial c

160 ulation may not be a prerequisite for TIMP-1 regulation of apoptosis in general.

161 ell line can be used as a model to study the regulation of apoptosis in human pituitary cells.

162 of GSH and ionic homeostasis converge in the regulation of apoptosis in lymphoid cells.

163 gene expression of mediators involved in the regulation of apoptosis in neural tissues of both WKY an

164 poptotic activity and may participate in the regulation of apoptosis in normal lymphocytes.

165 fects of IL-11 are mediated via differential regulation of apoptosis in oligodendrocytes versus Ag-pr

166 es and point to a striking similarity in the regulation of apoptosis in postmitotic cells.

167 nositide-3-kinase (PI3K)/Akt pathway, in the regulation of apoptosis in primary human erythroid proge

168 size the central role of mitochondria in the regulation of apoptosis in prostate cancer cells.

169 Regulation of apoptosis in response to viral infection i

170 re activated by stress and are implicated in regulation of apoptosis in several tissues.

171 ng protein of HIV-1, Tat, has a dual role in regulation of apoptosis in T cells.

172 ously unrecognized function of villin in the regulation of apoptosis in the gastrointestinal epitheli

173 umor necrosis factor alpha (TNFalpha) and up-regulation of apoptosis in the marrow.

174 an important role in cell viability and the regulation of apoptosis in vitro.

175 of Cdk5 activator p35-binding protein C53 in regulation of apoptosis induced by genotoxic stress thro

176 level and that BAP31 may be involved in the regulation of apoptosis induced by the ER overload respo

177 ha) and epidermal growth factor (EGF) in the regulation of apoptosis induced by transforming growth f

178 The regulation of apoptosis is a complex process and involve

179 The regulation of apoptosis is critical for controlling tiss

180 Tight regulation of apoptosis is essential for metazoan develo

181 PK kinase activation that is involved in the regulation of apoptosis is less well understood.

182 This regulation of apoptosis is linked to Vpr suppression of

183 Regulation of apoptosis is not affected by Smad3 levels.

184 ins, but the role of this interaction in the regulation of apoptosis is not known.

185 Regulation of apoptosis is tightly linked with the targe

186 y tumor suppressor genes are involved in the regulation of apoptosis, it is unclear whether menin fac

187 The modulated genes are mainly involved in regulation of apoptosis leading to exaggerated DNA-damag

188 ted in breast and lung cancers, and splicing regulation of apoptosis-linked pre-mRNAs by SPF45 was sh

189 Alterations in the regulation of apoptosis may contribute to the pathogenes

190 Recent discoveries reveal that dynamic regulation of apoptosis may heighten the vulnerability o

191 Our experiments implicate FAC in the regulation of apoptosis mediated by the Fas death recept

192 is a multifunctional protein involved in the regulation of apoptosis, mitochondrial morphology, and a

193 Beyond regulation of apoptosis, multiple BCL-2 proteins have re

194 ignaling molecule with proposed roles in the regulation of apoptosis, nuclear factor-kappaB activatio

195 ve activation of the MAPK-signaling pathway, regulation of apoptosis, or glycolysis.

196 Down-regulation of apoptosis pathways is one of the key deter

197 Regulation of apoptosis (programmed cell death) is criti

198 Protein kinase B (PKB) is involved in the regulation of apoptosis, protein synthesis and glycogen

199 tem has previously been shown to rely on the regulation of apoptosis rather than proliferation; howev

200 of caspases have been studied extensively in regulation of apoptosis, recent discoveries have highlig

201 of these interactions, implicated Ruk in the regulation of apoptosis, receptor endocytosis and cytosk

202 d gene expression profiling to determine the regulation of apoptosis-related genes by ATO in 4 MM cel

203 t whole cell lysates revealed Act-induced up-regulation of apoptosis-related proteins, including the

204 and the role of oxygen free radicals in the regulation of apoptosis remain unknown.

205 we conclude that endogenous hSPRY2-mediated regulation of apoptosis requires c-Cbl and is manifested

206 During animal development, the proper regulation of apoptosis requires the precise spatial and

207 be cleaved, identifying a novel mechanism of regulation of apoptosis sensitivity by mitochondrial Bcl

208 This model system allows pharmacological regulation of apoptosis sensitivity in the same cells in

209 AX and BCL2, two other genes associated with regulation of apoptosis, showed no overall correlation w

210 s possible mechanisms for AGP activation and regulation of apoptosis-signaling pathways in tumor cell

211 ther investigate the role of p21(ras) in the regulation of apoptosis, the cellular mechanisms employe

212 amined the interplay between Akt activation, regulation of apoptosis, the unfolded protein response,

213 Regulation of apoptosis, therefore, is linked intrinsica

214 ical role of Bcl-2 cysteine oxidation in the regulation of apoptosis through ERK signaling.

215 ed with the cellular localization of MDM2 in regulation of apoptosis through inhibiting PI3k/Akt sign

216 line of evidence for STRA13 involvement into regulation of apoptosis via the STAT pathways.

217 Autocrine regulation of apoptosis was demonstrated by increased Fa

218 Paracrine regulation of apoptosis was suggested by the induction o

219 nase whose activity has been correlated with regulation of apoptosis, was roughly twofold higher in F

220 tify potential mechanisms of transcriptional regulation of apoptosis, we assessed FOXO1 and caspase 3

221 lpains, and Bcl-2 have a pivotal role in the regulation of apoptosis, we hypothesized that ischemic p

222 investigate the role of Myb proteins in the regulation of apoptosis, we studied the apoptotic respon

223 reviously reported studies that analyzed HBx regulation of apoptosis were conducted in immortalized o

224 Several genes involved in the regulation of apoptosis were expressed normally with the

225 these molecules suggest that pharmaceutical regulation of apoptosis will have broad implications tha

226 uggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system