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1 with chronicity, with FOXK1 acting as immune regulator.
2 ntified agonists of this important metabolic regulator.
3 was demonstrated to be an indole-responsive regulator.
4 ession of miRNA-485, as a PGC1alpha upstream regulator.
5 their post-translational and transcriptional regulators.
6 ns, assess network topology and identify key regulators.
7 incomplete cytokinesis or muscle fusion pore regulators.
8 ated by transcription factors and epigenetic regulators.
9 ased on the input from expert scientists and regulators.
10 an by altered acetylation of other autophagy regulators.
11 rive expression of key viral transcriptional regulators.
12 RNAs also function as global transcriptional regulators.
13 he recruitment and the ejection of chromatin regulators.
14 dentify severe asthma genes and their master regulators.
15 functionally, due to IFN-I-induced negative regulators.
17 of LZTR1 (leucine zipper-like transcription regulator 1), an adaptor for CUL3 (CULLIN3) ubiquitin li
19 a reduction in expression of the autoimmune regulator (Aire), a critical mediator of central immune
23 lts convey the potent role of DR3 as an ILC2 regulator and introduce DR3 agonistic treatment as a nov
24 der-recognized multifactorial role as both a regulator and target of stress hormone signaling within
25 These data were analyzed to predict upstream regulators and affected signaling pathways following ars
26 by combining new targeted agents with immune regulators and chimeric antigen receptor-expressing natu
28 six antimicrobial peptides, two plant immune regulators and eight chemicals which inhibit Candidatus
29 mensions can control local concentrations of regulators and influence the emergent behavior of mitoti
30 Six1 targets a wide range of hair-bundle regulators and late Six1 deletion disrupts hair-bundle p
32 xtraordinary opportunity to pinpoint crucial regulators and target genes responsible for complex dise
34 PTB domains as a scaffold for a range of Rab regulators, and also the VPS13 family of proteins which
38 CFH), a major alternative complement pathway regulator, are associated with the development of age-re
39 Activating mutations of EZH2, an epigenetic regulator, are present in approximately 20% of patients
40 unsaturated PA in foods is a concern to food regulators around the world because these compounds have
42 NA (siRNA)-based down-regulation of an actin regulator, by pharmacological inhibition of actin polyme
45 eased Tnf expression, decreased a cell cycle regulator (Ccnb1), and increased apoptotic factors (Aifm
47 oexpressed with CF transmembrane conductance regulator (CFTR) along with transcription factors that h
48 s, cystic fibrosis transmembrane conductance regulator (CFTR)-rich ionocytes, and immune cells(1,2).
51 ERalpha) is a ligand-dependent transcription regulator, containing two transactivation functional dom
53 e mitochondrial permeability transition pore regulator cyclophilin D (CypD) promotes NGSIS, but not g
54 egulates expression of the key seed dormancy regulator, DELAY OF GERMINATION1, is a typical represent
57 map, and a knockout of a predicted upstream regulator disrupts normal regeneration, validating our p
58 e development in vivo The competence shutoff regulator DprA was highly expressed during pneumonia-der
60 nding to VEGFRs is an important angiogenesis regulator, especially the earliest-known isoform, VEGF-A
62 -induced hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21) was blunte
63 hroughput CRISPR screening using a ubiquitin regulator-focused single-guide RNA library in HL lines c
64 r work reveals TiPARP as a negative-feedback regulator for multiple oncogenic transcription factors,
66 gnalling but also requires inhibition by the regulator fructose 1,6-bisphosphate, which senses the up
68 homeotic mutation in the co-transcriptional regulator gene NODULE ROOT1 (MtNOOT1) converts legume-ty
70 comitant changes in the expression of floral regulator genes suggest that these processes are a prere
71 ation in the sorbitol operon transcriptional regulator gutR was associated with increased bacterial g
72 ding the mode of action of these non-protein regulators has been an intense area of research in recen
73 ylation, and thereby activation, of response regulators has been demonstrated to occur by their cogna
76 matrix modifiers (MMP12 and SPARCL1), immune regulators (IDO1, SOCS3, and IL10), and a proinflammator
78 findings strongly implicate TSPAN-7 as a key regulator in determining the set-point of glucose-stimul
81 a genome-wide annotation of transcriptional regulators in A. fumigatus and construction of a library
82 are the most common type of transcriptional regulators in prokaryotes and function by altering gene
83 Adult-specific manipulation of homeostatic regulators in the fly's auditory neurons accelerated - o
85 of transcriptional and post-transcriptional regulators, including microRNAs (miRNAs), coordinate the
86 ting of selected stress-response and cambium regulators indicated ERF-1 as a potential key checkpoint
87 on the immune receptors and transcriptional regulators involved in T cell quiescence and activation,
88 this context, the expression of the "master regulator" is necessary and sufficient to activate linea
89 e to nutrient stress, including the upstream regulator KLF15, aminoacid catabolizing enzymes, notably
90 ergenic non-coding RNA-Nucleotide Metabolism Regulator (lincNMR) is a long non-coding RNA (lncRNA) wh
92 d to identify enriched pathways and upstream regulators.Measurements and Main Results: Responses to R
95 utive loss or acute inhibition of the Arp2/3 regulator, N-WASP, which is associated with enhanced sig
97 ctile ring formation, we show that the ECT-2 regulator NOP-1, but not centralspindlin, is essential f
99 and thus we identify a role of Ppargamma as regulator of a functionally related class of AF-miRNAs.
101 he activity of heparan sulfate, an important regulator of a wide range of biological cell functions.
102 nding protein annexin A3 (AnxA3), a negative regulator of adipocyte differentiation, is down-regulate
104 ted in the presence or absence of the master regulator of antioxidant defense nuclear factor erythroi
105 ntly examined the role of a newly identified regulator of atherosclerotic burden in miR-144 knockout
106 i CDK-related kinase 5 (CRK5), is a critical regulator of atypical mitosis in the gametogony and is r
107 domain containing 66 (CCDC66) and TOG array regulator of axonemal microtubules 1 (TOGARAM1) as ARMC9
109 X-A and OX-B, is firmly established as a key regulator of behavioral arousal, sleep, and wakefulness
113 TRADD(4-6), an adaptor protein, as a direct regulator of both cellular homeostasis and apoptosis.
114 lcium-dependent protein kinase CPK3 is a key regulator of both pattern-triggered immunity and effecto
115 ntify alphaV-integrin (CD51) as an essential regulator of cardiac PW1(+) cells fibrogenic behavior.
116 demonstrate that the CTK complex is negative regulator of cat-3 expression by affecting its chromatin
119 e blebbing is now recognized as an important regulator of cell migration, cancer cell invasion, and v
120 nt protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism.
121 es initiating chondrogenesis, SOX9 acts as a regulator of cellular metabolism by suppressing oxidatio
123 -related, matrix-associated, actin-dependent regulator of chromatin, subfamily D, member 2) has recen
125 although NTA has gained recognition as a key regulator of crucial processes such as protein turnover,
126 ling pathway has been considered as a master regulator of cytoprotective genes, and exists in many ce
127 he ortholog of the ASD risk gene Taok2, as a regulator of dendritic arborization in sensory neurons.
128 R subdomains defined by seipin (Fld1), and a regulator of diacylglycerol (DAG) production, Nem1.
130 MP-activated protein kinase (AMPK), a master regulator of energy metabolism, in response to ZIKV chal
134 ltogether, these data show that bHLH121 is a regulator of Fe homeostasis that acts upstream of FIT in
135 ing transcription factor 4 (ATF4) as a novel regulator of fetal gamma-globin gene expression in human
136 sor, RbsR, was also defined as a pleiotropic regulator of flotation and virulence factor elaboration
137 cular studies within this region highlighted regulator of G-protein signaling 4 (Rgs4) within laser-c
140 e or nonsense variants in a known epigenetic regulator of gene expression: ten-eleven translocation m
147 -regulated anion channels (VRAC), as a vital regulator of hypotonicity-induced, but not DAMP-induced,
148 Here, we identified c-Maf as an essential regulator of ILC3 homeostasis and plasticity that limits
150 noxide, bilirubin, and iron, is an important regulator of inflammation and epithelial responses in th
152 2 (CITED2) as a critical intrinsic negative regulator of inflammation, which broadly attenuates pro-
154 tly interacts with IR to serve as a feedback regulator of insulin action in control of liver metaboli
157 In this review, we focus on PIP(2) as a regulator of ion channels in smooth muscle cells and end
158 in (HTT) protein has emerged as an important regulator of its localization, structure, aggregation, c
160 antly expressed in hepatocytes as a critical regulator of lipid metabolism, and clinical trials targe
161 hat transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy(4,5), is
163 signal regulatory protein alpha, a negative regulator of macrophage phagocytosis allowing repression
165 how that transcription factor AP2 (Tfap2), a regulator of mammalian germ lines, acts to commit adult
167 They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis sp
170 211 has previously been shown to be a direct regulator of metabolism in BRAF(V600E)-mutant melanoma c
173 abenula complex is appreciated as a critical regulator of motivated and pathological behavioral state
175 f DNA damage responses 1 (REDD1), a negative regulator of mTOR/protein kinase B, is poorly understood
177 xpectedly, one top hit was Traf3, a negative regulator of NF-kappaB signaling that has never previous
178 ous studies suggested that NRARP, a negative regulator of Notch signaling, could have a suppressive r
179 ur identification of EGLN3, a known negative regulator of nuclear factor kappaB (NF-kappaB), as a dir
183 ligase by Egr2, the central transcriptional regulator of peripheral myelination, to its target genes
185 findings suggest that TRIM32 functions as a regulator of PKCzeta that controls the differentiation o
186 Our results establish BIN2 as a central regulator of platelet activation in thrombosis and throm
187 Together our data identify LYN as a key regulator of pMo development and a potential therapeutic
191 n conclusion, we identified FOSL1 as a novel regulator of sepsis-induced deviant angiogenic signaling
193 e alpha (RPTPalpha) is an important positive regulator of SRC kinase activation and a known promoter
194 ults identify mTOR signaling as an important regulator of striatal functions through an intricate mec
195 he E3 ubiquitin ligase Peli1 as an important regulator of T cell metabolism and antitumor immunity.
196 the tumor microenvironment and as a negative regulator of T-cell tumor infiltration and patient survi
197 ific role of PFN2 as a stable interactor and regulator of the actin N-terminal acetyltransferase NAA8
199 o, MCs hindered activation of cMET, a master regulator of the basal program, and simultaneously promo
201 ulum (ER), is a recently identified negative regulator of the ER-associated retinal pigment epitheliu
202 gy and that UBQLN2 functions as an important regulator of the expression and stability of ATP6v1g1.
203 irectional promoter with MAP3K4, an upstream regulator of the MAPK signaling pathway, and regulates i
204 ction of NIN-LIKE PROTEIN 7 (NLP7), a master regulator of the nitrogen signaling pathway in plants.
208 if-containing protein 1 (SARM1) is a central regulator of this neurodegenerative process(5-8), and it
209 indings demonstrate that EphA4 is a negative regulator of Tie2 receptor signaling, which limits pial
216 s in gene expression levels of key enzymatic regulators of biochemical reactions linked to transmethy
217 cytidine residues, are now recognized as key regulators of both cellular and viral mRNA function.
219 ic entry due to overaccumulation of negative regulators of cell cycle such as Wee1-like protein kinas
225 he expression profiles of central epigenetic regulators of DNA methylation, histone modifications and
228 e show that MADS78 and MADS 79 are essential regulators of early seed developmental transition and im
229 Histone deacetylases (HDACs) are important regulators of gene expression that are aberrantly regula
231 iew, we posit that SPs are central chromatin regulators of gene silencing that establish immune cell
232 ple GRNs within a species to detect putative regulators of important plant pathways and provides pote
234 nd tribbles pseudokinase 3 (TRIB3), negative regulators of innate immune signaling, in HT-29 intestin
235 sulinemia through targeting several critical regulators of insulin secretion and beta cell proliferat
237 ormation by trafficking PA and/or PIP, known regulators of membrane trafficking between organellar su
239 molecules (dscam and dscaml1) are essential regulators of neural circuit assembly, but their roles i
241 an important role for two WRKYs as positive regulators of plant immunity against bacterial and poten
242 ptor) alpha and gamma, known transcriptional regulators of postnatal mitochondrial biogenesis and fun
243 tein degradation have emerged as fundamental regulators of proteome complexity that regulate stem cel
244 , we identified PTEN and DNA-PK as essential regulators of replication checkpoint arrest in response
247 AMTA2, and CAMTA3 (CAMTA123) serve as master regulators of salicylic acid (SA)-mediated immunity, rep
250 analyses identify Pbx3 and Meis1 as critical regulators of tail regeneration and axon organization.
252 junctions and connexin hemichannels are key regulators of the biology of neural progenitors during d
253 as a broad transcriptional repressor of key regulators of the cell cycle, in turn influencing contac
256 that were previously identified as negative regulators of the type-II interferon response (for examp
257 rion and its associated proteins are crucial regulators of these responses and related pathways such
258 of circulating miRNAs, which were predicted regulators of transcripts downregulated in the bone marr
259 BC200 and the rodent analog BC1 as negative regulators of translation in both cell-based and in vitr
264 patiotemporal expression of the plasmodesmal regulator PDLP5 in cells overlying LRP, creating a negat
265 unomodulatory and antibiofilm innate defense regulator peptide (IDR)-1018 based on three different sy
266 t activation of the glucose/lipid metabolism regulator peroxisome proliferator-activated receptor gam
268 We identify a quartet of transcriptional regulators promoting hPSC self-renewal including ZNF398,
271 eveal that, in planta, the majority of these regulators repress the transcription of genes encoding c
273 through the up-regulation of the EMT master regulator Slug, a process that is dependent on both MEK/
277 ion and degradation of several transcription regulators, such as LMO2, LMO4, LHX2, LHX3, LDB1, and th
278 use shorter FLS interact with SNX9, an actin regulator that binds phosphoinositides during endocytosi
280 identify TEX15 as a new essential epigenetic regulator that may function as a nuclear effector of MIL
281 Tfap2c and Tead4 induce expression of actin regulators that control the recruitment of apical protei
283 tiotemporal localization dynamics of the key regulators that master the two intertwined and transient
284 st that ringer acts as a hub for microtubule regulators that relays cellular status information, such
285 luding calcium transporters and cytoskeletal regulators, that are associated with the RB and may be i
287 our data reveal that -31CBS acts as critical regulator to define +19-enhancer and the leukemic prone
288 demic researchers, clinicians, patients, and regulators to discuss methods to advance the development
289 evelopment of allosteric HDAC inhibitors and regulators to improve the therapy for several disease st
290 ress, bacteria utilize iron-dependent global regulators to sense the iron status of the cell and regu
291 s study, we found that another key virulence regulator, ToxR, was important for V. cholerae resistanc
292 ridization to identify novel transcriptional regulators, we show that chromatin remodeler Hmga1 is hi
293 c epithelial cells expressing the autoimmune regulator were detected within 10 days of gene transfer,
295 to enhance translation of key morphogenetic regulators, while also destabilizing sentinel mRNAs that
297 4 (BRD4) is a transcriptional and epigenetic regulator with intrinsic kinase and histone acetyltransf