ライフサイエンスコーパス: regulatory

1 e learning algorithms trained to predict the regulatory activity of nucleic acid sequences have revea

2 ntributed to the functional deficits in gene regulatory activity of the mutant ERalpha proteins.

3 ating information relating to transcription, regulatory activity, chromatin accessibility, chromatin

4 of lineage-specific TE insertions to recent regulatory adaptations remain poorly understood.

5 representatives from academia, industry, and regulatory agencies convened to consider the guidance in

6 In the absence of drugs approved by regulatory agencies, the current standard of care remain

7 an Medicines Agency, European medical device regulatory agencies, US Food and Drug Administration, as

8 lished among the pharmaceutical industry and regulatory agencies.

9 While their regulatory and diagnostic potential has gained a substan

10 onist antibodies reduces the proportion of T-regulatory and exhausted T cells in pancreatic tumors an

11 anding the dual function of mitoproteases as regulatory and quality control enzymes will help unravel

12 )2, T(H)9, T follicular helper, T follicular regulatory, and regulatory T cells.

13 ning on a broad set of coding, conserved and regulatory annotations.

14 has led to the development of scientific and regulatory approaches for evaluating bioactivity.

15 tics, ammonia uptake, and toxicology to seek regulatory approval for a first-in-human study.

16 Although regulatory approval of this approach is still pending, p

17 ried reasons why vaccines fail to advance to regulatory approval.

18 vailable in oncology, especially with recent regulatory approvals of rituximab, trastuzumab, and beva

19 cuss whether unique GRN organization and cis-regulatory architecture underlies this special class of

20 s data from the Connecticut Public Utilities Regulatory Authority to describe trends in medical exemp

21 ion to the HY5/PIF-dependent shoot module, a regulatory axis composed of auxin biosynthesis and auxin

22 rtunities to effectively target endocan-EGFR regulatory axis in patients with TKI-resistant NSCLC.

23 levels of microRNA-155 and PU.1 (as upstream regulatory axis of FcepsilonRI) and transcription factor

24 e model of MS, adoptive transfer of IL-10(+) regulatory B cells (B(regs)) has been shown to reverse E

25 optimal functioning of human IL-10 producing regulatory B cells.

26 eatment or every 8 weeks pending approval by regulatory bodies and availability.

27 ent fragmentation of the standardization and regulatory body landscape.

28 ergent properties that provide the cell with regulatory capabilities beyond canonical molecular regul

29 cific CD8 T cells unexpectedly harbor immune regulatory capacity in both mouse and human.

30 alamic kisspeptin neurons serve as the nodal regulatory centre of reproductive function.

31 Diverse traits have evolved through cis-regulatory changes in genome sequence that influence the

32 entiate direct miRNA targets from downstream regulatory changes.

33 atory loops constitutes core transcriptional regulatory circuitry (CRC).

34 ational change that allows gD to bind to the regulatory complex gH/gL, which then activates the fusog

35 ew, we address how a broadly operational RNA regulatory complex interfaces with cell type-specific ma

36 Our study demonstrates another level of regulatory complexity underlying the spationumerical reg

37 Our work reveals important regulatory components of the neuronal circuitry that und

38 Consistent with these regulatory connections, Yap/Taz accumulated upon Myc/bet

39 ple approach for functionally annotating the regulatory consequences of CNVs.

40 Regulatory constraints to which this industry is bound w

41 ng methods and technologies aimed at tighter regulatory control through bioengineering approaches, al

42 o another protein in response to appropriate regulatory cues.

43 mostly in food and beverage groups in which regulatory cutoffs were below the 75th percentile of the

44 nOVAmax induced a regulatory DC phenotype evidenced by a decrease of the a

45 archical model, called Bayesian Inference of Regulatory Differences, which integrates prior informati

46 transporters, we propose that exaptation by regulatory divergence contributed to the evolution of QD

47 effects are available to compensate for cis-regulatory divergence.

48 e coordinate system and vocabulary for human regulatory DNA marked by DHSs, and provide a new global

49 specific chromatin accessibility solely from regulatory DNA sequences.

50 minal effector domain (NTD) and a C-terminal regulatory domain (CTD); a carotenoid spans the two doma

51 hat UBA(Cez) can indeed fulfill this role as regulatory domain by binding various ubiquitin chain typ

52 artially truncate its C-terminal cytoplasmic regulatory domain impair NHE6 activity and endosomal fun

53 de of transcription inhibition involving the regulatory domain of sigma subunit, and potentially pinp

54 The regulatory dynamics and functional significance of putat

55 o determine how 14-3-3 relieves the negative regulatory effect of ATP through a 2.5- angstrom-resolut

56 While the regulatory effect of RUNX3 in beta-catenin is already kn

57 re, we characterized the dynamics of genetic regulatory effects at eight time points during memory CD

58 genetic variation on neuronal function, the regulatory effects of MORs on synaptic transmission were

59 The present study focuses on delineating the regulatory effects of the SUMO-SIM interaction on ICP0 E

60 ions and characterizing their cis- and trans-regulatory effects on gene expression (particularly, tra

61 g-based methods allows for the prediction of regulatory effects per variant on several cell type-spec

62 t-mortem brains to quantify their dosage and regulatory effects.

63 H10 are target genes repressed by the HOTAIR regulatory element and that both function in regulating

64 strate that the disulfide bond is a critical regulatory element of SrrB function during S. aureus inf

65 asis in animal cells is maintained by sterol regulatory element-binding proteins (SREBPs), membrane-b

66 We mapped candidate cis-regulatory elements (cCREs) and linked them to putative

67 d the dynamic activities of a variety of cis-regulatory elements (CREs) in ER stress-responsive gene

68 These frequently mutated regulatory elements (FMREs) were ubiquitously active in

69 Those iMs appear to be genomic regulatory elements and might modulate transcription in

70 PRDM16 binds to cis-regulatory elements and represses the expression of regi

71 ovide the tissue specificity afforded by cis-regulatory elements and the conditionality of optogeneti

72 he RNA m(6)A modification, including the cis-regulatory elements and trans-acting factors that determ

73 ges, we observed that the majority of distal regulatory elements are constitutively unmethylated thro

74 Regulatory elements drive the cortical expression of SCR

75 provided limited insight into the biology of regulatory elements due to the difficulty of interpretin

76 y and single-cell expression data shows that regulatory elements gradually become accessible within p

77 riptional outputs of thousands of individual regulatory elements in embryonic stem cells and measure

78 as a widely used tool for identifying active regulatory elements in eukaryotes.

79 analysis to validate cell-type-specific cis-regulatory elements in heterogeneous populations of prim

80 ughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission.

81 ication, we identify neuron-subtype-specific regulatory elements that previously went undetected in b

82 en proposed to spatially sequester genes and regulatory elements through chromatin looping.

83 As, lncRNAs, chromatin accessibility and cis-regulatory elements uncover a core mRNA-ncRNA transcript

84 ignals, insulators prevent the cross-talk of regulatory elements within adjacent loci and safeguard t

85 are over-represented in memory CD4(+) T cell regulatory elements(1-3).

86 (P<0.01), applied a Markov model to classify regulatory elements, and annotated this model with match

87 asma cells showed an extensive activation of regulatory elements, in part affecting coregulated adjac

88 WAS association signals and reports relevant regulatory elements, tissue contexts and plausible targe

89 ne promoters to integrate inputs from distal regulatory elements, yet how this is achieved remains po

90 loops as well as loops linking promoters to regulatory elements.

91 tion to promote increased occupancy of their regulatory elements.

92 is a powerful approach to identify potential regulatory elements.

93 e-specific TEs in studying evolution of gene regulatory elements.

94 and logic of the cell cycle, identified key regulatory enzymes that drive the cell cycle, elucidated

95 We previously described the regulatory events that control the timely synthesis of N

96 We have recently demonstrated that IFN regulatory factor (IRF) 8 was dispensable for caspase-11

97 y demonstrated that the Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) promotes C3aR functions in

98 Interferon regulatory factor 3 (IRF3) and IRF7 are closely related

99 and rs3902920 in GSDMB colocalized with IFN regulatory factor binding sites and associated with GSDM

100 tive effects of IFN-I require the interferon regulatory factor IRF5, which upregulates genes encoding

101 o multiple components rather than any single regulatory factor or promoter sequence motif.

102 -Kinase Anchor Protein (AKAP8) as a splicing regulatory factor that impedes EMT and breast cancer met

103 ferentiation is controlled by diverse master regulatory factors across the animal kingdom.

104 s are orchestrated and regulated by myogenic regulatory factors and various downstream cellular signa

105 MS and AIDP-Wb, we rapidly identify multiple regulatory factors that specifically bind in an allele-i

106 These neurons are subjected to a plethora of regulatory factors that ultimately affect the release of

107 Alternative pathway (AP) regulatory factors were quantified by ELISA (n = 181) an

108 elated with decreased phosphorylation of IFN regulatory factory 7 (IRF7) and NF-kappaB.

109 athway, where the oxidation of metabolic and regulatory Fe-S centers of proteins by LCO disrupts meta

110 1 (AP-1) and investigated the JNK-AP-1-RUNX1 regulatory feedback loop, which can be modulated by VEGF

111 the bulk nuclear nanoenvironment as a novel regulatory framework for gene expression.

112 c health will benefit if proper policies and regulatory frameworks are implemented before the complet

113 ndings uncover that the H4 basic patch has a regulatory function in SAGA-mediated histone modificatio

114 ng anti-FH Ab is able to restore the surface regulatory function of most of the tested FH mutants to

115 ific MMP14 overexpression model to study its regulatory function.

116 domain of RPTPs is believed to mostly play a regulatory function; however, no regulatory model has be

117 The GTEx data set revealed regulatory functions of rs6008845 on PPARA expression in

118 led studies regarding isoform-specific early regulatory functions of the dynamins are lacking.

119 id-targeted proteins for all biochemical and regulatory functions.

120 nge in expression of the cardiac contractile regulatory gene cmlc2 was also seen in ventricles from 2

121 mental defects after knockdown of a critical regulatory gene, and permit modeling of viral infection.

122 dentical in sequence across all effector and regulatory genes but differ in duplication of the pcbAB-

123 ueled by variation in expression patterns of regulatory genes causing changes in anisotropic cell exp

124 d mice and examined the roles of upregulated regulatory genes in bacterial virulence.

125 9 screen against NRF2 target and other redox regulatory genes in both 2D- and 3D-culture systems, unc

126 Thus, the study of regulatory genes in these species during inflorescence a

127 erived macrophages, heme induced HO-1, lipid regulatory genes including LXR (lipid X receptor), the g

128 plex and partial duplication of fragments of regulatory genes.

129 In humans and rodents, the iron-regulatory hormone hepcidin is profoundly decreased in p

130 ula-ventral striatal circuitry and metabolic regulatory hormones that warrant further study.

131 up oil spills is rapidly advancing but faces regulatory hurdles and environmental concerns.

132 However, its regulatory implications have not been examined.

133 riptional co-activator Yorkie with its major regulatory input provided by the Hippo-Warts kinase casc

134 igm describing how differential responses to regulatory inputs generate complex patterns of binary an

135 orks (TRNs) is an effective way to study the regulatory interactions between the transcription factor

136 cumulation is of considerable scientific and regulatory interest.

137 ysteine thiols to modulate the activities of regulatory kinases and phosphatases.

138 This review summarizes the regulatory landscape, applications to clinical practice,

139 layer interaction network composed of a gene regulatory layer, a protein-protein interaction layer, a

140 ediated enhancer blocking establish a direct regulatory link between this enhancer and lncRNAs PCAT1,

141 boundaries enables deconvolution of complex regulatory loci into modular units.

142 e we report the localization of the melanoma regulatory locus to a single gene, rab3d, which shows al

143 A consensus regulatory loop (miR17/miR20a-FOXE1-PDGFRA) and eight mi

144 program; the ensemble of core TFs and their regulatory loops constitutes core transcriptional regula

145 ew technologies that can extend the standard regulatory mapping framework to more diverse, disease-re

146 an active conformation reveals an additional regulatory mechanism for AAA+ ATPases.

147 Our results reveal prolyl isomerization as a regulatory mechanism for SthK, and potentially eukaryoti

148 e innate immune response with the same basic regulatory mechanism for the human and mouse genes.

149 gh-throughput iCLIP approaches to identify a regulatory mechanism for U2AF2 RNA recognition.

150 We propose a new regulatory mechanism governing glioma cell TMZ sensitivi

151 lture studies to identify a highly conserved regulatory mechanism linking anxiety and alcohol intake

152 We characterized a regulatory mechanism of endodermal differentiation drive

153 The regulatory mechanism of FgMsb3 has been further investig

154 Allostery is a fundamental regulatory mechanism of protein function.

155 y lineage decision and on a yet unidentified regulatory mechanism, which can provide spatiotemporal c

156 Many other regulatory mechanisms can influence RNA metabolism and t

157 turb and observe" genetic screens to uncover regulatory mechanisms driving complex mammalian signalin

158 utoff, suggesting the presence of additional regulatory mechanisms enabling expression of the self-de

159 our study helps understand the comprehensive regulatory mechanisms for craniofacial development.

160 c Ocean points to the need for international regulatory mechanisms for persistent and mobile organic

161 Multiple regulatory mechanisms have been identified employing con

162 work and report the involvement of different regulatory mechanisms in PML II recognition by ICP0 in H

163 cent studies have unveiled a wide variety of regulatory mechanisms including autoregulation, post-tra

164 cuses on recent progress in illuminating the regulatory mechanisms of ABA signal transduction, and th

165 To gain a better understanding of the regulatory mechanisms of HIV-1 replication, we adapted a

166 their target genes, affected cell types and regulatory mechanisms remain unknown.

167 r cardiomyocyte maturation and summarize key regulatory mechanisms that promote and coordinate these

168 an integral part of the complex landscape of regulatory mechanisms underlying cell differentiation.

169 tory capabilities beyond canonical molecular regulatory mechanisms.

170 y effective treatment, suggesting additional regulatory mechanisms.

171 stly play a regulatory function; however, no regulatory model has been established for RPTPalpha-D2 o

172 e-cell RNA-seq data, we showed that the core regulatory modules can reflect the properties of differe

173 brotic mechanisms are controlled by multiple regulatory molecules, including MAPKs, in turn regulated

174 quality sensors are promising supplements to regulatory monitors for PM(2.5) exposure assessment.

175 ress its own synthesis, is the most abundant regulatory motif known to biology.

176 f networked activities in the brain-the gene regulatory network (GRN)-that orchestrates expression le

177 rative analysis that combines proteomics and regulatory network analysis infers the interaction betwe

178 Key components of the photosynthesis gene regulatory network differentially accumulated between me

179 e of use, even by non-specialists, make gene regulatory network inference available to any researcher

180 specific traits require integration into the regulatory network of the cell and are often controlled

181 changes in gene expression(1), but the gene regulatory network that controls oocyte growth remains u

182 that MpaR function is integrated into the QS regulatory network.

183 ween SHR's availability and the state of the regulatory network.

184 NA profiles provides insight into their gene regulatory network.

185 s made it difficult to decipher the p63 gene regulatory network.

186 Gene regulatory networks (GRNs) link transcription factors (T

187 Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity o

188 Analysis of the topology of transcriptional regulatory networks (TRNs) is an effective way to study

189 The complexity and principles of these regulatory networks are only beginning to be understood.

190 Gene regulatory networks are typically constructed from gene

191 developmental stage-specific transcriptional regulatory networks by linking enhancers and predicted b

192 Mapping the gene-regulatory networks dysregulated in human disease would

193 Regulatory networks important for regeneration are const

194 e particularly suitable for dissecting miRNA regulatory networks in vivo.

195 Based on these promoters, regulatory networks of higher complexity are assembled,

196 studies pertaining to the metabolic and gene regulatory networks operating in the glandular trichomes

197 g their essential role in the maintenance of regulatory networks that affect the intricacy of the org

198 he emergent outcomes of vast, interconnected regulatory networks that influence cell fates and lineag

199 d at DARs during differentiation, indicating regulatory networks that likely drive GIN development.

200 due to the dense and noisy nature of current regulatory networks, directly comparing the gains and lo

201 ity of biological systems is encoded in gene regulatory networks.

202 ntify AHR signalling in enteric neurons as a regulatory node that integrates the luminal environment

203 rate an enrichment of potentially disruptive regulatory noncoding DNVs in a fraction of CHD at least

204 ted to the ability of lncRNAs to function as regulatory noncoding transcripts, there is growing evide

205 er of T cells poised to quickly develop into regulatory or effector cells, depending on the needs of

206 eatures indicative of proteomic, structural, regulatory or evolutionary relevance and integrate them

207 rization can be adapted to achieve different regulatory outcomes.

208 Therefore, we have identified a gene regulatory pathway involving CsCLV3, CsWUS, CsFUL1(A) an

209 Conservation of this regulatory pathway was confirmed in human psoriasis usin

210 NBCn2 and the IRBITs are at the nexus of the regulatory pathways for multiple renal transport process

211 o provide insight into manipulation of these regulatory pathways to improve stomatal behavior and ide

212 ins (DRMs) within the ER, also called the ER regulatory pool of cholesterol.

213 tal nitrogen supply, affecting multiple gene regulatory processes including genome-wide histone modif

214 rovides knowledge potentially applicable for regulatory product approval.

215 e United States' first regional market-based regulatory program designed to reduce greenhouse gas emi

216 nable the robust and precise changes in gene-regulatory programs during signaling and development.

217 I) that fundamentally alters the thermal and regulatory properties of Rca in bread wheat (Triticum ae

218 and show how it can rigorously quantify gene regulatory properties suggested by experiment.

219 2+) influx pathway in endothelial cells, and regulatory protein AKAP150 (A-kinase anchoring protein 1

220 ficiency with the expression of human signal regulatory protein alpha, a negative regulator of macrop

221 cient Rat Rag-/- Gamma chain-/- human signal regulatory protein alpha-positive (RRGS) rats combining

222 F-kappaB essential modulator (NEMO) is a key regulatory protein that functions during NF-kappaB- and

223 TrkH assembles with its regulatory protein, TrkA, which closes the channel when

224 Understanding how oncogenic mutations rewire regulatory-protein networks is important for rationalizi

225 Cell-cycle regulatory proteins (p21(Cip1) /p27(Kip1) ) inhibit cycl

226 d active states differ by small changes in a regulatory region that extends up to 28 angstrom from th

227 ignificantly over-represented in active gene regulatory regions and transcription factor binding site

228 -guanines (CpGs) in gene promoters and other regulatory regions by specific demethylase(s) generates

229 BRD4 direct association to chromatin regulatory regions of the NADPH oxidase subunits increas

230 the noncoding genome, and found deletions in regulatory regions that contribute to disease causation.

231 imuli to chromatin, acting at super-enhancer regulatory regions to direct gene expression.

232 gene regulation mediated by accessibility of regulatory regions to transcription factors (TFs).

233 ptor (GR) and STAT3 bind to the same genomic regulatory regions, which were specifically open and unm

234 stence of an underlying adaptive codon-based regulatory response inherent to the genetic code.

235 Comparisons among the transcriptional regulatory responses of these six ERalpha genotypes to a

236 o which CodY exerts its effect through small regulatory RNAs (sRNAs).

237 anscription or RNA processing factors, these regulatory RNAs perform critical roles in gene expressio

238 ies have suggested that dynamin also plays a regulatory role during the early stages of CME; however,

239 The findings reveal a regulatory role for a GABAergic signaling machinery in t

240 tral role of NAD in plant metabolism and its regulatory role have been investigated extensively at th

241 t dynamic RNA methylation plays an important regulatory role in oligodendrocyte development and CNS m

242 To provide insights into the regulatory role of enhancer-associated non-coding varian

243 Gene silencing approaches confirmed the regulatory role of HIF-1alpha in BACE1-AS/BACE1 in Tat-m

244 The primary regulatory role of Hot216, and specifically the gene enc

245 The core nucleosome performs a fundamental regulatory role, apart from the histone "tails," which m

246 Consistent with a repressive regulatory role, DDX3 localized to cytoplasmic puncta wi

247 These results support the regulatory roles for inherited noncoding variants in the

248 hat plays key structural, developmental, and regulatory roles in skeletal and cardiac muscle.

249 ibrosis suggests they may have unanticipated regulatory roles.

250 r-induced nuclear translocation of Raptor, a regulatory scaffolding component in mTORC1, and localiza

251 gene by a fusion-mediated repositioning of a regulatory sequence is much more common than previously

252 the formation of an activating or repressive regulatory sequence.

253 o assess the spatiotemporal activity of Gdf5 regulatory sequences in experimental OA following destab

254 and in the hypertrophic ventricle, involving regulatory sequences proximal to Nppa.

255 expression is dictated by cell-type specific regulatory sequences that physically organize the struct

256 compensation, provided that autosomal trans-regulatory sequences with sex-limited effects are availa

257 e-of-the-art performance in identifying gene regulatory sequences, but they have provided limited ins

258 NAs, transcribed bidirectionally from active regulatory sequences, whose expression levels correlate

259 observed a DNV burden in RNA-binding-protein regulatory sites (OR = 1.13, 95% CI 1.1-1.2, P = 8.8 x 1

260 ell imaging data measuring distances between regulatory sites during time is also discussed.

261 ed by the alpha2 helix dividing two distinct regulatory sites: Na(+) and the inhibitory peptide.

262 es with linear polyubiquitin chains is a key regulatory step in signal transduction that impacts cell

263 Theoretical modeling revealed that these regulatory strategies (bursting and the time window) res

264 regulatory system and propose an integrated regulatory structure.

265 n pharyngeal and rectal specimens to support regulatory submission.

266 Mutations of the regulatory subunit (PRKAR1A) of the cyclic adenosine mon

267 ion (LoF) variants in protein phosphatase 1, regulatory subunit 12a (PPP1R12A), an important developm

268 In this work, we examined Spo7, a regulatory subunit required for Nem1 catalytic function,

269 We found that the regulatory subunits of these AHAS complexes form a core

270 cificity through the interaction of distinct regulatory subunits with conserved catalytic subunits in

271 This work shows the deleteriousness of regulatory SVs, particularly those altering CTCF sites a

272 Thus, deep learning can reveal the regulatory syntax predictive of the full differentiative

273 ive strategy is achieved via a two-component regulatory system (BceRS) working in a sensory complex w

274 ption factor that is part of a developmental regulatory system and a ureteric bud marker.

275 signaling network and the histone-based gene regulatory system and propose an integrated regulatory s

276 entations of rhythms of multiple homeostatic regulatory systems.

277 PI3Kdelta is a key regulator of regulatory T (Treg) cell function.

278 critical for the function of thymus-derived regulatory T (Treg) cells (ie, FOXP3), resulting in impa

279 ncies of CXCR5(-) memory Th cells as well as regulatory T and B cells were increased.

280 sion block that can be released by impairing regulatory T cell associated signaling pathways.

281 and proliferative states and no evidence of regulatory T cell depletion.

282 This was associated with promoting the regulatory T cell-inducing molecule retinoic acid, inhib

283 expression by cDC is not required for CD4(+) regulatory T cell-mediated control of colitis.

284 Regulatory T cells (T(reg) cells) restrict immune system

285 une cells including activated CD4(+)Foxp3(+) regulatory T cells (Tregs) and CD4(+)Foxp3(-) convention

286 FOXP3+CD4+ regulatory T cells (Tregs) are critical for immune homeo

287 immune response by inducing infiltration of regulatory T cells and expression of immune-suppressive

288 We showed that depletion of regulatory T cells prior to infection with B. burgdorfer

289 ge-dependent expansion of ovalbumin-specific regulatory T cells was only observed in infants who (a)

290 atients received one of six CBMPs containing regulatory T cells, dendritic cells, or macrophages; pat

291 licular helper, T follicular regulatory, and regulatory T cells.

292 tates, including multiple distinct states of regulatory T cells.

293 ed the precursors of M2 macrophages, DCs and regulatory T cells.

294 with the presence of functional effector and regulatory T-cell subsets with diverse T-cell receptor c

295 bset, it accounted for more than 25% of CD4+ regulatory T-cell variation and over 50% of CD8+ central

296 shifts in the phosphorylation states of its regulatory targets.

297 f T follicular helper cells and T follicular regulatory (Tfr) cells that regulate germinal center res

298 In summary, we have found a common PPARA regulatory variant that influences the cardiovascular ef

299 er, the identification of individual, causal regulatory variants is challenging.

300 how different molecular mechanisms generate regulatory variation, and studies comparing these mutati