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1 Sho1p for binding via its N-terminal soluble regulatory domain.
2 only MKK containing three motifs within its regulatory domain.
3 mino acids within the SP-3 motif of the NFAT regulatory domain.
4 havior and interaction mechanism of the MKK7 regulatory domain.
5 idation of tandem methionine residues in its regulatory domain.
6 ctive state by phosphorylating Y(529) in its regulatory domain.
7 f a photosensory core and a carboxy-terminal regulatory domain.
8 l (DAG) through its interactions with the C1 regulatory domain.
9 linked to a protease catalytic domain and a regulatory domain.
10 ily diversity have focused on the C-terminal regulatory domain.
11 tide PapR on a tetratricopeptide repeat-type regulatory domain.
12 1 with truncation of its C-terminal negative-regulatory domain.
13 ed form of the enzyme lacking the N-terminal regulatory domain.
14 en share structural similarities with a bEBP regulatory domain.
15 14-3-3 proteins, to the phosphorylated Adr1 regulatory domain.
16 nding of allosteric effector tyrosine to the regulatory domain.
17 lude the structural switch of the downstream regulatory domain.
18 ic domain by a conserved helix in the kinase regulatory domain.
19 that the C-terminal domain of TREK1 is a key regulatory domain.
20 is regulated by cGMP binding to GAF-A in its regulatory domain.
21 he AAA+ domain that bypass repression by the regulatory domain.
22 -mRNA in beewolf eggs lacks an exon near the regulatory domain.
23 nding of purine nucleotides to an allosteric regulatory domain.
24 ted on opposite sides of the SczA C-terminal regulatory domain.
25 y PARP-1 on three amino acids in a conserved regulatory domain.
26 on and prevents Smo accumulation through Krz regulatory domain.
27 within or adjacent to the protein's negative regulatory domain.
28 in vivo, and we identify a potential second regulatory domain.
29 truncated form of CBS lacking the C-terminal regulatory domain.
30 the polygenic signal across different genome regulatory domains.
31 well as in several of its multiple putative regulatory domains.
32 the carotenoid spanning the effector and the regulatory domains.
33 enomic studies have identified many types of regulatory domains.
34 nhibited by the assembly of similar adjacent regulatory domains.
35 n that revealed sharp boundaries of the BX-C regulatory domains.
36 ects of genetic variation by expanding their regulatory domains.
37 ther housekeeping genes that reside in large regulatory domains.
38 the Btk kinase domain in the absence of the regulatory domains.
39 th the nucleotide-binding and the C-terminal regulatory domains.
40 e between the proximal and distal C-terminal regulatory domains.
41 NA-binding domain/linker to seven additional regulatory domains.
42 architecture of discrete loops and potential regulatory domains.
43 ated with the organization of chromatin into regulatory domains.
44 rs the interaction between the catalytic and regulatory domains.
45 n modular, containing distinct catalytic and regulatory domains.
46 ic activation induces a repositioning of the regulatory domains.
47 se TeMC representatives containing different regulatory domains.
48 Stp2, freeing them from negative N-terminal regulatory domains.
49 ifts in the conformational equilibria of the regulatory domains.
50 which is located between the iab-6 and iab-7 regulatory domains.
51 E3 ligase for SUMOylation of the cell cycle regulatory domain 1 (CRD1) of CBP, which is located adja
53 ects a previously identified transcriptional regulatory domain 3 (TRD3) for which co-regulators remai
55 he majority of them consist of an N-terminal regulatory domain, a central AAA domain and a C-terminal
56 ults indicate that individual regions in the regulatory domain act in a distinct manner to control PK
59 which corresponds to an extension to the TH regulatory domain, also interacts with negatively charge
60 r is controlled by three major transcription regulatory domains: an inducible proximal promoter, an u
61 d by phosphorylation of serine residues in a regulatory domain and by binding of catecholamines to th
63 al truncation mutations lack a transcription regulatory domain and have increased DNA binding through
64 op of the kinase domain is stabilized by the regulatory domain and how the kinase linker region inter
65 regulated via acetylation of p53 C-terminal regulatory domain and phosphorylation of H1.2 C-terminal
66 oy a novel minichromosome model of the hGH-N regulatory domain and show that HSII confers robust POU1
67 ong-distance communication between the iab-6 regulatory domain and the Abd-B gene, while the Pita, Su
68 the effect of mutations that alter the Mcm4 regulatory domain and the Rad53 targets, Sld3 and Dbf4.
69 nosylmethionine (AdoMet), which binds to the regulatory domain and triggers a conformational change t
70 th an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 pepti
71 : they must block crosstalk between adjacent regulatory domains and at the same time facilitate bound
72 ylalanine stabilizes the dimerization of the regulatory domains and exposes the active site for subst
73 sidase gene flanked by two estrogen receptor regulatory domains and intervening Asp-Glu-Val-Glu seque
74 existence of a recombination rate valley at regulatory domains and provide a potential molecular mec
77 sive, non-conserved interfaces between their regulatory domains and the 18 amino acids that serve as
78 nal regions of FH: the N-terminal complement regulatory domains and the C-terminal surface-recognitio
79 on genes have retained or lost functional or regulatory domains and these features impacted tumorigen
80 two nucleotide-binding domains (NBDs), and a regulatory domain, and its channel assembly requires mul
81 ange kinetics of a mutant enzyme lacking the regulatory domain are limited to peptides surrounding th
83 murine leukemia virus, architectures of the regulatory domains are similar and reveal common princip
84 regions, such as first introns of genes and regulatory domains, are associated with important risk f
85 active limb enhancer cluster from the Epha4 regulatory domain at different positions within a neighb
87 )) matches the rate of Ca(2+) binding to the regulatory domain but also dominates the motion of the I
88 -BRAF fusion lacking the BRAF autoinhibitory regulatory domain but retaining an intact kinase domain.
89 hat UBA(Cez) can indeed fulfill this role as regulatory domain by binding various ubiquitin chain typ
92 tal structure detailing how the receptor and regulatory domains communicate in a ligand-dependent fas
93 ulfate proteoglycan that has a cell adhesion regulatory domain contained within its extracellular cor
94 They consist of three domains: an N-terminal regulatory domain containing four calcium-binding EF-han
95 The structure of a truncated version of the regulatory domain containing residues 65-159 has been de
96 a auto-repression also involves a C-terminal regulatory domain (CRD) adjacent to the leucine zipper.
97 ctionally modular, comprised of a C-terminal regulatory domain (CTD), an N-terminal effector domain (
100 minal effector domain (NTD) and a C-terminal regulatory domain (CTD); a carotenoid spans the two doma
102 tionship between recombination rate and gene regulatory domains, defined by a gene and its linked con
103 alytic domain of TDP1 lacking the N-terminal regulatory domain (Delta1-147), suggesting an allosteric
106 ted state of the PheH tetramer depicting the regulatory domains docked against the catalytic domains
107 domain (L188P and G383D), and the C-terminal regulatory domain (E547*, R568Q, and W570*) of human NHE
108 itutively active PKC-zeta mutant lacking all regulatory domain elements and containing "activating" g
109 s the interactions between the catalytic and regulatory domains, enhancing the interaction with calmo
111 domain as a second important transcriptional regulatory domain for Brd4 in addition to the carboxyl-t
112 ind that a RUNX1 domain, termed the negative regulatory domain for DNA binding, can compensate for th
114 Here, we present crystal structures of GAF regulatory domains for Aquifex aeolicus sigma(54) activa
120 sis of IFNL1 promoter revealed that positive-regulatory domain I and IFN-stimulated response element
122 trait, cardiac troponin T, investigation of regulatory domains identified a locus on chromosome 9.
123 artially truncate its C-terminal cytoplasmic regulatory domain impair NHE6 activity and endosomal fun
124 It thus appears that phosphorylation of a regulatory domain in 4.1R results in structural changes
125 teraction with calmodulin, but maintains the regulatory domain in a dynamic unstructured conformation
129 found that CoA directly binds to the CaMKII regulatory domain in the absence of Ca(2+) to activate C
132 ty elements (IE) located in their C-terminal regulatory domains in a process that is sensitive to cyc
134 individual protein kinase Calpha (PKCalpha) regulatory domains in maintaining catalytic autoinhibiti
137 he view that the PASYybT domains function as regulatory domains in the modulation of cellular cyclic
138 tion pathway relies on structurally distinct regulatory domains including one transmembrane voltage-s
140 g proteins (SREBPs) through their C-terminal regulatory domains, inhibiting SREBP processing and acti
141 fusions we show that Bmh binding to the Adr1 regulatory domain inhibits an Adr1 activation domain but
143 at both the 14-3-3 protein Bmh2 and the Snf1 regulatory domain interact with the arrestin-like domain
144 tional equilibrium of PLN, whose cytoplasmic regulatory domain interconverts between three different
147 om autoinhibitory constraints imposed by the regulatory domain is catalytically competent and that Th
150 ction between Mus101 and the Top2 C-terminal regulatory domain is phosphorylation-dependent because t
151 ivate JNK, activator protein-1, and positive regulatory domain IV to transcriptionally regulate the I
152 n of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes
153 athic alpha-helix is bound to a cleft in the regulatory domain, leading to substrate transport by the
156 ctive interplay of the ATPase motor with the regulatory domains may promote dynamic nucleosome struct
157 transgenic reporters using Tet1 and Tet2 cis-regulatory domains may serve to distinguish nuanced chan
162 on involves a conformeric equilibrium of the regulatory domain, modulating substrate and nucleotide a
164 Cdk phosphorylation sites in its N-terminal regulatory domain, most or all of which contribute to in
167 the frequency and relevance to resistance of regulatory domain mutations in CML patients on imatinib,
170 any transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of t
172 ng mutations of the glycine-serine-rich (GS) regulatory domain of ACVR1, encoding bone morphogenetic
174 sensing domain of one HTCS, BT1754, and the regulatory domain of another HTCS, BT0366, to explore th
177 hree amino-acid substitutions in an internal regulatory domain of CEBPB that are responsible for the
179 cTnC, including TNT1, cTnT linker, I-T arm, regulatory domain of cTnI, the D-E linker of cTnC, and s
180 tire mRNA cleft and makes connections to the regulatory domain of eIF2?, eIF1A, and ribosomal element
181 ibits interaction of GBP with the N-terminal regulatory domain of GluTR1, thus making it accessible t
183 he functions executed by Sld3, Dbf4, and the regulatory domain of Mcm4 intersect to control origin fi
187 ted regulatory domain (RDPheH(25-117) is the regulatory domain of PheH lacking residues 1-24) of the
189 an unexpected accessibility of the terminal regulatory domain of plasma membrane H(+)-ATPase to prot
190 centrifugation establishes that the isolated regulatory domain of R68S PheH is predominantly monomeri
192 ntacts, and find they require the structured regulatory domain of Rgt1, but no known interaction part
193 s in a three-residue motif of the C-terminal regulatory domain of RIG-I that physically interacts wit
195 unique hydrophobic pocket in the allosteric regulatory domain of RIPK1 has enabled the development o
197 de of transcription inhibition involving the regulatory domain of sigma subunit, and potentially pinp
198 (ELC), and adjacent heavy chain (HC) in the regulatory domain of smooth muscle heavy meromyosin.
202 ontrast to other Ca2+-regulated kinases, the regulatory domain of TgCDPK1 plays a dual role, inhibiti
203 gene in C. elegans and show that loss of the regulatory domain of the CaMKI enzyme produces thermal a
206 rements of the orientation of the IT arm and regulatory domain of troponin, which together form the t
207 phosphorylation sites within the N-terminal regulatory domain of UNG2 have been identified, although
209 abolish the antiviral activity of C-terminal regulatory domains of both RIG-I and DRH-1 in C. elegans
211 Here, we determined the structures of the regulatory domains of E. coli and B. subtilis MutL bound
212 tion rate valley is most pronounced for gene regulatory domains of early embryonic development genes,
213 olesterol needs, and subsequently from PM to regulatory domains of ER to suppress activation of SREBP
214 s in which Ser(700), located between the two regulatory domains of K(+) conductance (RCK) immediately
215 Buried extensively within the C-terminal regulatory domains of Rv3249c and Rv1816, we found fortu
216 conduit for transmitting the presence of the regulatory domains of Tec kinases to the catalytic domai
217 re revealing that the N-terminal DCB and HUS regulatory domains of the Arf-GEF Sec7 form a single str
218 ting the interface between the catalytic and regulatory domains of the enzyme, shifting the equilibri
219 Here, we show that sequence variation in regulatory domains of the fruit-tissue identity gene, IN
220 f specific genes and should also incorporate regulatory domains of the human genome with critical ram
222 and gene regulation, the ligand-binding and regulatory domains of the S(MK) box riboswitch are coinc
223 that CDK1-cyclin B1 phosphorylates the RNMT regulatory domain on T77 during G2/M phase of the cell c
225 characterization indicates that, within the regulatory domain, only the clamp binding motif is requi
226 domain that binds an effector molecule and a regulatory domain (or expression platform) that instruct
228 talytic domain, a site at the PAH N-terminal regulatory domain (PAH-RD), to activate the enzyme via a
229 captures and subsequently phosphorylates the regulatory domain peptide of a donor kinase forming a ch
230 Using comparative NMR analyses of a key regulatory domain, PfD, in its apo, cGMP-bound, and cGMP
232 homology to phosphotransferase system (PTS) regulatory domains (PRDs) found in sugar operon regulato
233 re transcriptional regulators, named for PTS Regulatory Domains (PRDs) subject to phosphorylation by
235 olishing the catalytic center and C-terminal regulatory domain, produced opaque seeds with depleted s
236 the kinase domain: AMP binding to the gamma-regulatory domain promotes phosphorylation by the upstre
237 eable AXP (AMP/ADP/ATP) binding sites on the regulatory domain protects the enzyme from dephosphoryla
238 igomerisation domains form a core from which regulatory domains protrude, positioning themselves clos
239 he pleckstrin homology domain (P domain) and regulatory domain (R domain) were critical in mediating
242 undergoes trans-autophosphorylation within a regulatory domain, referred to as the activation loop, w
243 known interactions between the C1a and other regulatory domains releases the autoinhibited interactio
245 the transcriptional start site an important regulatory domain resides in intron 1 of the gene itself
246 g this interaction between the catalytic and regulatory domains reveals a direct correlation between
247 The 1.7 A structure of a AdoMet-bound CBS regulatory domain shows one AdoMet molecule per monomer,
249 de the x-ray crystal structure of cone GAFab regulatory domain solved at 3.3 angstrom resolution, in
252 ancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known
254 nding causing a conformational change in the regulatory domain that alters the interaction between th
255 mational change in the Bateman module of the regulatory domain that favors its association with a Bat
256 ukaryotic MCM helicase contains an intrinsic regulatory domain that integrates multiple signals to co
257 nel is activated by PKA phosphorylation of a regulatory domain that interacts dynamically with multip
259 helicase subunit, possesses an unstructured regulatory domain that mediates control from multiple ki
260 ent cytoplasmic precursor with an N-terminal regulatory domain that restricts its nuclear accumulatio
261 uenching, while the C-terminal domain is the regulatory domain that senses light and induces photoact
263 e bithorax complex (BX-C) delimit autonomous regulatory domains that drive parasegment-specific expre
264 plex (BX-C) of Drosophila delimit autonomous regulatory domains that drive parasegment-specific expre
265 ANE territory separates into inner and outer regulatory domains that express the cardinal ANE transcr
266 hus, a single amino acid substitution in the regulatory domain (the tetratricopeptide repeat domain)
267 e high-affinity cGMP binding site within the regulatory domain, the altered PKG-1 is constitutively a
269 passes the sizes of genes, gene clusters and regulatory domains, the three-dimensional (3D) organizat
270 egion contains the following transcriptional regulatory domains: the acidic region, the WUS-box, whic
271 leosome sliding is tightly controlled by two regulatory domains: the DNA-binding domain, which interf
274 ory region are transmitted to the C-terminal regulatory domain to initiate the signalling cascade, is
275 s a new host cofactor that utilizes distinct regulatory domains to bind incoming HIV-1 particles and
276 inases, creating opportunities to target the regulatory domains to control the function of these kina
277 ional cell surface receptor that has several regulatory domains to control various biological process
278 4) activators use several different kinds of regulatory domains to respond to a wide variety of intra
279 domain at the N-terminus and sharing similar regulatory domains to the mammalian neuronal NOS (nNOS).
282 ensity attributable to the troponin-I mobile regulatory domain was positioned where it could hold tro
283 er evidence for the presence of a C-terminal regulatory domain was provided by single-amino-acid subs
284 g a myo1c construct containing the motor and regulatory domains, we found the force dependence of the
285 ARP-1 is over 500 residues and includes four regulatory domains, whereas PARP-2 and PARP-3 have small
286 ion in the absence of the Pax3 transcription regulatory domains, whereas Splotch Pax3 did not stimula
287 re inactive without assembly of the adjacent regulatory domains, whereas the Src kinase domains are a
288 g of S-adenosyl-l-methionine (AdoMet) to its regulatory domain, which activates its catalytic domain.
289 ins, and we propose they constitute a master regulatory domain, which contains overlapping molecular
290 -Thr382-Thr383 cluster within the C-terminal regulatory domain, which stabilizes PTEN, resulting in i
291 gments phosphorylate SPRTN at the C-terminal regulatory domain, which stimulates SPRTN recruitment to
292 d by the intermolecular accessibility of its regulatory domains, which can be allosterically modulate
293 x3 locus forms a CTCF-independent autonomous regulatory domain with multiple combinatorial regulatory
294 structure-function analysis reveals a set of regulatory domains with activities that restrict Gek fun
295 eved in a regulator that contains duplicated regulatory domains with distinct dimerization properties
297 ce and arrangement between the catalytic and regulatory domains within the CBS oligomer, thereby incr
298 chitectures that revealed a diverse array of regulatory domains within Trichodesmium metacaspases-lik
299 at observed in yeast, as well as in positive-regulatory domain zinc finger protein 9-knockout mice, s