ライフサイエンスコーパス: regulatory enzyme

1 ATHIONINE gamma-SYNTHASE (AtCGS), Met's main regulatory enzyme.

2 the molecular architecture of this important regulatory enzyme.

3 of structure-function relationships of this regulatory enzyme.

4 ct binding of a kinesin-related protein to a regulatory enzyme.

5 of acetyl-CoA carboxylase, a major upstream regulatory enzyme.

6 n of potent and selective inhibitors of this regulatory enzyme.

7 nit interactions, resulting in an allosteric regulatory enzyme.

8 operties and effector sensitivities of these regulatory enzymes.

9 biopterin (BH4) is a cofactor of a number of regulatory enzymes.

10 eomic approach, we identified the glycolytic regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6

11 However, with the exception of a few key regulatory enzymes, a comprehensive and quantitative ass

12 y functional human E2 that mediated enhanced regulatory enzyme activities but, lacking E3BP, supporte

13 '-AMP, is a potent activator of an important regulatory enzyme, AMP-activated protein kinase (AMPK).

14 that HDAC3 represses the synthesis of a key regulatory enzyme and reveal a novel mechanism by which

15 tion and cooperative properties of bacterial regulatory enzymes and hemoglobin.

16 ugh genetic analyses, we uncovered roles for regulatory enzymes and mitochondrial localization in the

17 ssociated with hyperlipidemia, altered lipid regulatory enzymes and receptors, and increased risk of

18 his issue, we examined the expression of S1P regulatory enzymes and S1P receptors during cardiac deve

19 sed to describe the allosteric properties of regulatory enzymes and subsequently extended to receptor

20 However, its regulatory enzymes and substrate proteins remain unknown

21 Renal expression of vitamin D regulatory enzymes and vitamin D receptor was higher in

22 e self-association and activity of important regulatory enzymes, and examined conformational properti

23 Other critical regulatory enzymes are also associated with NCX1, includ

24 e macromolecular complex suggests that these regulatory enzymes are coordinately positioned to regula

25 The functions of regulatory enzymes are essential to modulating cellular

26 The activities of both regulatory enzymes are regulated in vivo as described in

27 tone lactylation is installed and removed by regulatory enzymes as opposed to spontaneous chemical re

28 l, even though brain neurons express the key regulatory enzymes associated with building or burning g

29 ,4-trisphosphate 5/6-kinase (ITPK1) is a key regulatory enzyme at the branch point for the synthesis

30 moserine dehydrogenase (HSD) function as key regulatory enzymes at branch points in the aspartate ami

31 ntiation anti-cancer agents target chromatin regulatory enzymes buoyed early interest in developing d

32 encodes a member of the Pak family of actin-regulatory enzymes, but whose in vivo function is unknow

33 ing as both protein quality surveillance and regulatory enzymes by performing highly regulated proteo

34 ulations of MASS models explicitly show that regulatory enzymes can control dynamic states of network

35 Rare variants (RVs) in the gene encoding the regulatory enzyme complement factor I (CFI; FI) that red

36 dvances in our understanding of how PTMs and regulatory enzymes control the signaling activity of RLR

37 suggest the EGAP NAT complex is an essential regulatory enzyme controlling the function of a subset o

38 we demonstrate that prostaglandin E2 and its regulatory enzyme, COX-2, are also targets of Tpl2-trans

39 nthesis by increasing phosphorylation of the regulatory enzyme CTP:phosphocholine cytidylyltransferas

40 ectively inhibiting the activity of the rate-regulatory enzyme, CTP:phosphocholine cytdylyltransferas

41 ctivity in plants, and identified a critical regulatory enzyme, cytosolic phosphoribosyl pyrophosphat

42 -Brucella interactions, we utilized c-di-GMP regulatory enzyme deletion mutants.

43 is frequently considered vested in classical regulatory enzymes, each strongly displaced from equilib

44 Protein kinases constitute a large family of regulatory enzymes, each with a distinct specificity to

45 to the coupling cation Na(+) and also to the regulatory enzyme EIIA(Glc) of the glucose-specific phos

46 enerated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide gl

47 hat S. mutans ADP-Glc PPase is an allosteric regulatory enzyme exhibiting sensitivity to modulation b

48 ine cytidylyltransferase (Pcyt2) is the main regulatory enzyme for de novo biosynthesis of phosphatid

49 he expression of ent-kaurene synthase, a key regulatory enzyme for gibberellin synthesis, the followi

50 ee-fold increase in the activity of the rate-regulatory enzyme for PC synthesis, cytidylyltransferase

51 spects of ADP-glucose pyrophosphorylase, the regulatory enzyme for starch biosynthesis.

52 '-phosphate hydrolase has been proposed as a regulatory enzyme for vitamin B-6, but we found B-6 vita

53 l histidine kinases (HKs) are quintessential regulatory enzymes found ubiquitously in bacteria.

54 r structural principles operate in bacterial regulatory enzymes, gene repressors (and the related nuc

55 a mechanism through which a single chromatin regulatory enzyme has the ability to sense chemical micr

56 il now the identity or the function of these regulatory enzymes has not been defined in any crop plan

57 At reduced activities, the classic regulatory enzymes, hexokinase and glycogen phosphorylas

58 atory T cells and was mediated by the immune-regulatory enzyme IDO and TGF-beta.

59 ndritic cells (DCs) competent to express the regulatory enzyme IDO in mice are a small but distinctiv

60 inactivate GS kinase-3beta (GSK-3beta), the regulatory enzyme immediately upstream of GS, by serine

61 de strong evidence that NCED is indeed a key regulatory enzyme in ABA biosynthesis in leaves, and dem

62 Although it has never been reported as a regulatory enzyme in any system studied to date, kinetic

63 ene determining the activity of an important regulatory enzyme in catecholamine inactivation is assoc

64 of phosphoglucomutase 1 (PGM), an important regulatory enzyme in cellular glucose utilization and en

65 antothenate kinase 2 (PANK2) is an essential regulatory enzyme in coenzyme A biosynthesis.

66 ivates acetyl-CoA carboxylase (ACC), the key regulatory enzyme in fatty acid biosynthesis, in the arc

67 er fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by

68 a PSTK for M. xanthus PFK (Mx-PFK), the key regulatory enzyme in glycolysis.

69 ession of fatty acid synthase (FAS), the key regulatory enzyme in lipid biosynthesis.

70 n lipin 1 phosphatidate phosphatase is a key regulatory enzyme in lipid metabolism.

71 The key regulatory enzyme in melatonin synthesis is arylalkylami

72 Glycine N-methyltransferase (GNMT) is a key regulatory enzyme in methyl group metabolism.

73 oding putrescine N-methyl transferase, a key regulatory enzyme in nicotine formation.

74 cceptor) oxidoreductase, EC 1.7.99.5), a key regulatory enzyme in one-carbon metabolism, results in a

75 holine cytidylyltransferase (CCT) is the key regulatory enzyme in phosphatidylcholine (PC) synthesis

76 idermal ornithine decarboxylase (ODC), a key regulatory enzyme in polyamine biosynthesis, may suppres

77 hosphate dehydrogenase (IMPDH) is a critical regulatory enzyme in purine nucleotide biosynthesis that

78 cose (Glc) pyrophosphorylase (AGPase), a key regulatory enzyme in starch biosynthesis, is highly regu

79 -glucose pyrophosphorylase (AGPase) is a key regulatory enzyme in starch biosynthesis.

80 ADP-glucose pyrophosphorylase is a key regulatory enzyme in starch synthesis in most plant tiss

81 Ornithine decarboxylase is a key regulatory enzyme in the biosynthesis of polyamines, and

82 ADP-Glc pyrophosphorylase (PPase), a key regulatory enzyme in the biosynthetic pathway of starch

83 Pantothenate kinase (PanK) is the key regulatory enzyme in the CoA biosynthetic pathway in bac

84 Pantothenate kinase (PanK) is the key regulatory enzyme in the CoA biosynthetic pathway.

85 Pantothenate kinase (PanK) is a key regulatory enzyme in the coenzyme A (CoA) biosynthetic p

86 latter group as purF, which encodes the key regulatory enzyme in the de novo purine synthetic pathwa

87 monophosphate dehydrogenase (IMPDH) is a key regulatory enzyme in the de novo synthesis of the purine

88 ic acid (ACC) synthase which is an important regulatory enzyme in the ethylene biosynthetic pathway.

89 Chalcone synthase, a key regulatory enzyme in the flavonoid pathway, constitutes

90 The key regulatory enzyme in the gluconeogenesis pathway, fructo

91 a polypeptide revealed its identity as a key regulatory enzyme in the glycolytic pathway, namely phos

92 endent isocitrate dehydrogenase (IDH), a key regulatory enzyme in the Krebs cycle, is a multi-tetrame

93 ansferase (AANAT) is the penultimate and key regulatory enzyme in the melatonin biosynthetic pathway.

94 e to acetyl-CoA in mitochondria and is a key regulatory enzyme in the metabolism of glucose to acetyl

95 rnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme in the mevalonate pathway, catalyzes t

96 tors of IkappaB kinase-beta (IKKbeta), a key regulatory enzyme in the nuclear factor-kappaB (NF-kappa

97 CPT-Ialpha is a key regulatory enzyme in the oxidation of fatty acids in the

98 e to acetyl-CoA in mitochondria and is a key regulatory enzyme in the oxidation of glucose to acetyl-

99 Heme oxygenase-1 (HO-1) is the chief regulatory enzyme in the oxidative degradation of heme t

100 Glucokinase (GCK) is a key regulatory enzyme in the pancreatic beta-cell and cataly

101 lutaryl coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in the pathway for endogenous choleste

102 lutaryl-coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in the pathway for endogenous choleste

103 din-endoperoxide synthase 2 (PTGS2) is a key regulatory enzyme in the synthesis of the antifibrotic a

104 (PDE) of retinal photoreceptors is a central regulatory enzyme in the visual transduction pathway of

105 e cytidylyltransferase (CCT) is an important regulatory enzyme in this pathway and that its activity

106 bifunctional substrate preference of the key regulatory enzyme in tocopherol (vitamin E) biosynthesis

107 the trafficking and life span of a critical regulatory enzyme in vivo.

108 Three key regulatory enzymes in ganglioside biosynthesis, sialyltr

109 stinct compartmentalization of PP2A and PP2A regulatory enzymes in plasma membrane microdomains and i

110 Two key regulatory enzymes in the bile acid biosynthesis pathway

111 use the total amount of one of the principle regulatory enzymes in the extract (ACP, the enzyme compl

112 minant negative and dominant active forms of regulatory enzymes in the Ras/MAPK and PKB pathways and

113 apeutic potential of inhibiting two critical regulatory enzymes in this pathway-kynurenine-3-monooxyg

114 nfection stimulated expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in l

115 is uniquely competent to express the T-cell regulatory enzyme indoleamine 2,3-dioxygenase (IDO) in m

116 brain, AKAP79/150 incorporates PKA and other regulatory enzymes into signal transduction networks tha

117 Acid ceramidase (AC) is a key regulatory enzyme involved in ceramide metabolism, and m

118 Stearoyl-CoA desaturase (SCD) is a regulatory enzyme involved in the synthesis of the monou

119 alterations in protein expression levels of regulatory enzymes involved in glucose and choline metab

120 erations in the protein expression levels of regulatory enzymes involved in lipid metabolism, includi

121 A fundamental issue in allosteric regulatory enzymes is the identification of pathways of

122 e previously shown declining activity of the regulatory enzyme lactosylceramide N-acetylglucosaminylt

123 This key regulatory enzyme may modulate susceptibility to severe

124 affinity of receptors or in the activity of regulatory enzymes may alter the susceptibility of certa

125 -glucose pyrophosphorylase (AGPase) is a key regulatory enzyme of bacterial glycogen and plant starch

126 clopropane-1-carboxylic acid synthase, a key regulatory enzyme of ethylene biosynthesis) and LeIAA (A

127 encoding acetyl-CoA carboxylase-alpha, a key regulatory enzyme of fatty acid synthesis, is transcribe

128 e triphosphate citrate lyase (ACLY) is a key regulatory enzyme of glucose metabolism, cholesterol and

129 /fructose-2,6-bisphosphatase is an important regulatory enzyme of glucose metabolism.

130 Phosphorylase kinase, a regulatory enzyme of glycogenolysis in skeletal muscle,

131 equences of elevated levels of Pfkfb3, a key regulatory enzyme of glycolysis, and found that pharmaco

132 As a regulatory enzyme of glycolysis, inducible 6-phosphofruc

133 m of 6-phosphofructo-2-kinase (iPFK2), a key regulatory enzyme of glycolysis.

134 of JH acid methyltransferase (jhamt), a key regulatory enzyme of JH biosynthesis.

135 oadenylate phosphodiesterase (2'-PDE), a key regulatory enzyme of the interferon pathway.

136 oadenylate phosphodiesterase (2'-PDE), a key regulatory enzyme of the interferon pathway.

137 ose-5-phosphate synthase (DXS), an important regulatory enzyme of the mevalonate-independent pathway

138 onine decarboxylase (AdoMetDC) is a critical regulatory enzyme of the polyamine biosynthetic pathway

139 ACE2 is a regulatory enzyme of the renin-angiotensin system and ha

140 eved by AMP, an allosteric activator of this regulatory enzyme of the tricarboxylic acid cycle.

141 In the yeast Saccharomyces cerevisiae, key regulatory enzymes of gluconeogenesis such as fructose-1

142 (PCK1) and glucose-6-phosphatase (G6PC), key regulatory enzymes of hepatic gluconeogenesis.

143 nd neutral sphingomyelinase (NSMase) are key regulatory enzymes of sphingolipid metabolism, promoting

144 oA reductase and acetyl-CoA carboxylase (key regulatory enzymes of sterol synthesis and fatty acid sy

145 Regulatory enzymes often have different roles in distinc

146 ave demonstrated that flavonoids can inhibit regulatory enzymes or transcription factors important fo

147 rylation was attributed to inhibition of the regulatory enzyme pyruvate dehydrogenase.

148 Sirtuin enzymes and a substrate for multiple regulatory enzyme reactions within and outside the cell.

149 expression of the myofibrils and the calcium-regulatory enzyme SERCA2, and reduced the magnitude and

150 y showed that androgen induces the first and regulatory enzyme spermidine/spermine N1-acetyltransfera

151 es, which phosphorylate and thereby activate regulatory enzymes such as phospholipase C-gamma 1 and p

152 are reflected in the fractional states of a regulatory enzyme, such as the fraction of the total enz

153 teraction between these acylations and their regulatory enzymes, such as histone acetyltransferases,

154 rofiling to identify candidate substrates of regulatory enzymes, such as kinases and ubiquitin ligase

155 ne demethylase 5 (KDM5) family of epigenetic regulatory enzymes suppresses R-loop formation in genomi

156 nsferase (plsB) of Escherichia coli is a key regulatory enzyme that catalyzes the first committed ste

157 Pantothenate kinase (PanK) is a regulatory enzyme that controls coenzyme A (CoA) biosynt

158 on in catechol-O-methyltransferase (COMT), a regulatory enzyme that controls dopamine availability.

159 HMG1 is a key regulatory enzyme that controls the amounts of isoprenoi

160 RNase E is a key regulatory enzyme that controls the principal pathway fo

161 RNase E is an important regulatory enzyme that governs the principal pathway for

162 merous functional aspects of a key metabolic regulatory enzyme that is important for high-titer viral

163 RNase E is an important regulatory enzyme that plays a key role in RNA processin

164 cible 6-phosphofructo-2-kinase, a glycolysis-regulatory enzyme that protects against diet-induced int

165 tosolic phospholipase A(2) (cPLA(2)alpha), a regulatory enzyme that releases arachidonic acid (AA) fo

166 ndoleamine 2,3-dioxygenase 1 (IDO1) is a key regulatory enzyme that supports Treg function and periph

167 clear accumulation of Nrf1 proteins, but the regulatory enzymes that act on Nrf1 are not fully define

168 The regulatory enzymes that act to sustain centromeric cohes

169 Phosphatases are regulatory enzymes that antagonize the action of kinases

170 ansferase subunit is a member of a family of regulatory enzymes that are known to control a range of

171 Among the many regulatory enzymes that contribute to these processes is

172 is a complex process involving a variety of regulatory enzymes that control the intracellular respon

173 and logic of the cell cycle, identified key regulatory enzymes that drive the cell cycle, elucidated

174 ons along with the transcription factors and regulatory enzymes that have been previously identified

175 re that is specifically reduced by the redox-regulatory enzyme thioredoxin-f.

176 Hexokinase, the first regulatory enzyme to initiate glycolysis by converting g

177 increased by 40%) and the involvement of key regulatory enzymes, using isolated working rat hearts ex

178 hanism of tissue-specific expression of this regulatory enzyme, we characterized the major (type 2) C

179 1%; beta-HAD, 32%) and glycolytic (PFK, 18%) regulatory enzymes were also increased in mVEGF-/- mice.

180 redoxin reductases (TRs) are important redox regulatory enzymes, which control the redox state of thi

181 Cyclin-dependent kinases (Cdks) are regulatory enzymes with temporal and spatial selectivity

182 mic, effector-modified interactions of these regulatory enzymes with the flexibly held outer domains

183 (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance.

184 choline cytidylyltransferase (CCT), the rate-regulatory enzyme within the CDP-choline pathway, by 40%

185 taneous measurement of the activation of key regulatory enzymes within single cells.