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1 actors), and transcribed distal genes (trans-regulatory factors).
2 pting interactions of the enhancer with gene-regulatory factors.
3 gulatory elements targeted by a multitude of regulatory factors.
4 ence, but also on the local concentration of regulatory factors.
5 ostasis, 14 of which expressed hematopoietic regulatory factors.
6 ch further correlates with the expression of regulatory factors.
7 ources of data to improve predictions for AS regulatory factors.
8 me regulation by harboring binding sites for regulatory factors.
9 iled understanding of relevant developmental regulatory factors.
10 x that allow for interactions with different regulatory factors.
11 s consisting of local high concentrations of regulatory factors.
12 rigenesis and cell growth mediated by growth regulatory factors.
13 and also control half-lives of key cellular regulatory factors.
14 ractions with epigenetic machinery and other regulatory factors.
15 ecreased nuclear translocation of interferon regulatory factors.
16 hat represent enzymes, structural units, and regulatory factors.
17 I interferon (IFN) signaling and interferon regulatory factor 1 (IRF-1) expression is required to en
19 nt-associated swelling.IMPORTANCE Interferon regulatory factor 1 (IRF-1) is a transcription factor th
21 cy of antiviral tumor-suppressive interferon regulatory factor 1 (IRF-1) selectively promotes the mur
22 pha/IL-13Ralpha1 heteroreceptor to endow IFN regulatory factor 1 (IRF-1) with apoptotic functions, wh
23 uble-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcription factor
24 cells are defective in inducible interferon regulatory factor 1 (IRF1) expression by occluding RelA
26 enes, which occurs through antagonism of IFN regulatory factor 1 (IRF1)-mediated transcriptional acti
28 Tumor necrosis factor (TNF) and interferon regulatory factor 1 (IRFN1) were identified as key upstr
29 caffolding protein sodium-hydrogen exchanger regulatory factor 1 (NHERF1) interacts with the calcium
30 y demonstrated that the Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) promotes C3aR functions in
32 ctors of 53BP1, including replication timing regulatory factor 1 (RIF1) and Pax transactivation domai
33 we show that HHV-8-encoded viral interferon regulatory factor 1 (vIRF-1) promotes mitochondrial clea
34 dietary antigen was dependent on interferon regulatory factor 1 and dissociated from suppression of
35 -->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IF
36 IFN signaling pathway, such as IFN-beta, IFN regulatory factor 1, and guanylate-binding proteins.
37 ptor (CCR) 2, CCR5, the Na(+)/H(+) exchanger regulatory factor 1, CXCR3, alpha (1)-AR, and the opioid
38 h together with the transcription factor IFN regulatory factor 1, promoted maximum VCAM-1 expression.
41 induced nuclear translocation of interferon-regulatory factor-1 (IRF1) in hepatocytes in vivo, and C
42 NS5A, leading to activation of an interferon regulatory factor-1 (IRF1)-driven cell intrinsic antivir
45 ZR) to tether rPhe508del-Na(+)/H(+)-exchange regulatory factor-1 complexes to the actin cytoskeleton,
47 nd a cytosolic protein (Na(+)/H(+) exchanger regulatory factor-1; NHERF1) as examples, we demonstrate
48 AS(*) represses the expression of interferon regulatory factor 2 (IRF2), which in turn directly repre
49 on factor C3 (RFC3), FAM111A, and interferon regulatory factor 2 (IRF2)-were confirmed by custom assa
50 We also reported that SMAD ubiquitination regulatory factor 2 (SMURF2) ligase activity is importan
52 erferon genes-TANK-binding kinase-interferon regulatory factor 3 (cGAS-STING-TBK1-IRF3) signaling pat
53 ear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3), classically inducing IFNbet
54 racts with the host transcription factor IFN regulatory factor 3 (IRF-3), inhibiting its phosphorylat
55 ), TRIF-related adaptor molecule, interferon regulatory factor 3 (IRF-3), receptor-interacting protei
56 ding of IFI44L to FKBP5 decreased interferon regulatory factor 3 (IRF-3)-mediated and nuclear factor
57 t that exogenous IL-1beta induces interferon regulatory factor 3 (IRF3) activation in human myeloid,
58 r hand, DeltaN146 activates interferon (IFN) regulatory factor 3 (IRF3) and IFN expression, known to
59 via TANK binding kinase 1 (TBK1)/interferon regulatory factor 3 (IRF3) and inhibitor of nuclear fact
62 tivates the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor kappa-ligh
66 form a signaling complex that activates IFN regulatory factor 3 (IRF3) for transcriptional induction
68 86D) in ANDV N robustly inhibited interferon regulatory factor 3 (IRF3) phosphorylation and IFNbeta i
69 rmed that these miRNAs potentiate interferon regulatory factor 3 (IRF3) phosphorylation and transloca
71 orylates the transcription factor interferon regulatory factor 3 (IRF3) to promote interferon express
72 nding kinase 1 (TBK1) to activate interferon regulatory factor 3 (IRF3), resulting in production of t
73 e of inoculation independently of interferon regulatory factor 3 (IRF3)-, IRF7-, and IFNAR1-mediated
74 ERON GENES (STING), activating an INTERFERON REGULATORY FACTOR 3 (IRF3)-mediated immune response.
77 romoter when it was stimulated by interferon regulatory factor 3 (IRF3)/5D or its upstream molecules
78 s the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative effic
82 , and mice with disruption of the interferon regulatory factor 3 gene (Irf3(-/-)), with or without di
85 terleukin (IL)-6, IL-1beta, interferon (IFN) regulatory factor 3, and IFN-beta levels than BCG-wild t
86 appaB, but not TANK-binding kinase 1 and IFN regulatory factor 3, thereby inducing the expression of
87 it activated STING and its target interferon regulatory factor 3, which directly induced matrix metal
89 ampening the activation of NF-kappaB and IFN regulatory factor 3-mediated production of proinflammato
93 PV16 integrated into the promoter of the IFN regulatory factor 4 (IRF4) gene, which plays an importan
95 production, lung histopathology, interferon regulatory factor 4 (IRF4) mRNA expression, and nuclear
96 roducts, the transcription factor interferon regulatory factor 4 (IRF4) promotes regulatory T cell (T
98 demonstrated the importance of a GM-CSF->IFN regulatory factor 4 (IRF4)->CCL17 pathway, first identif
100 iated by the transcription factor interferon regulatory factor 4 and the chemokine receptor C-X-C mot
101 f the transcription factors IRF4 (interferon regulatory factor 4) and Bcl6, driving both early extraf
102 of the transcription factor IRF4 (interferon regulatory factor 4) in Tcl-1 transgenic mice developing
103 ent resulted in downregulation of interferon regulatory factor 4, a transcription factor for M2 macro
105 rentiation is associated with defects in IFN regulatory factor 4, B cell-activating transcription fac
106 und to be driven by 2 variants of interferon regulatory factor 4-dependent dermal type 2 conventional
109 dy found microglial expression of interferon regulatory factor 5 (IRF5) and IRF4 was related to pro-
114 g infection, transcription factor interferon regulatory factor 5 (IRF5) is essential for the control
117 ted LMP1 expression, we find that interferon regulatory factor 5 (IRF5), a direct target of p53, is a
118 tivity controls the activation of interferon regulatory factor 5 (IRF5), a transcription factor impli
120 es formulated with mRNAs encoding interferon regulatory factor 5 in combination with its activating k
121 or-alpha, the chemokine CCL2, and interferon regulatory factor-5 (IRF5), a marker of inflammatory mac
123 tions and common polymorphisms in interferon regulatory factor 6 ( IRF6) are associated with both syn
127 ignaling leading to NF-kappaB and interferon regulatory factor 7 (IRF7) activation has not been inves
128 ers showed increased basal expression of IFN regulatory factor 7 (IRF7) and IFN-beta, as well as incr
129 resist STAT1 phosphorylation and interferon regulatory factor 7 (IRF7) induction in response to exog
132 cluding the key ISG transcription factor IFN regulatory factor 7 (Irf7), were more highly induced aft
133 Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (
134 FN-beta-blocking antibody) or IFN-alpha (IFN regulatory factor 7 knockout [IRF7-KO] mice or mice trea
137 regs showed reduced expression of interferon regulatory factor 8 (IRF-8)/aldehyde dehydrogenase 1 fam
138 The homozygous K108E mutation of interferon regulatory factor 8 (IRF8) is reported to cause dendriti
140 ROCK2 directly phosphorylated interferon regulatory factor 8 (IRF8), a crucial mediator of GC res
141 the IFN-gamma response and repressed the IFN regulatory factor 8-regulated network that controls cent
144 In vitro, increased expression of interferon regulatory factor-9 and IRG1 and itaconic acid treatment
146 1 is not an miR93 target but that interferon regulatory factor-9, which can regulate IRG1 expression,
147 cted to examine the role of miR93-interferon regulatory factor-9-immunoresponsive gene-1 (IRG1)-itaco
148 he mechanisms through which lineage-specific regulatory factors achieve divergent functions over deve
149 q will enable the unbiased discovery of gene regulatory factors across diverse biological systems.
154 electively concentrates multiple microtubule regulatory factors and allows them to diffuse rapidly wi
155 nal cell types and characterized the driving regulatory factors and differentially accessible loci th
157 tor of gene expression is well known, the co-regulatory factors and local sequences acting at p53-bou
158 etic elements are probabilistic, interactive regulatory factors and not deterministic 'epialleles' wi
159 elective recruitment of cis-proline-specific regulatory factors and region-specific modulation of the
160 sured along with markers of RNA polymerase I regulatory factors and regulators of protein synthesis.
161 s are orchestrated and regulated by myogenic regulatory factors and various downstream cellular signa
162 y genetic variants proximal to the gene (cis-regulatory factors), and transcribed distal genes (trans
163 imentally validated cancer genes, chromosome regulatory factors, and DNA damage repair genes, as comp
166 tations in IRF8, which encodes an interferon regulatory factor, as a cause of familial NK cell defici
167 and rs3902920 in GSDMB colocalized with IFN regulatory factor binding sites and associated with GSDM
168 d populations of these states changed as the regulatory factors complexin and Munc13 were added.
169 n cord versus peripheral blood and to define regulatory factors controlling this proliferation, we co
172 cture and DNA modifications [i.e., chromatin regulatory factors (CRF)] and genes encoding histone pro
175 tein 1 (ZBP1)/DNA-dependent activator of IFN-regulatory factors (DAI) that contain receptor-interacti
176 eptors stimulates, in most cases, interferon regulatory factor-dependent type I IFN synthesis followe
177 erentiation and altered expression of muscle regulatory factors, embryonic myogenesis and formation o
179 T cell phenotype, for example expression of regulatory factors, especially when the virions were ops
181 In this study, we characterized hHB as a regulatory factor for the replication of RNA viruses by
185 RC2, and TrxG complexes, which are essential regulatory factors for the maintenance of transcriptiona
187 mportant physiological function for a Pol II regulatory factor (Gdown1) in the maintenance of normal
189 ontain binding sites for one or more General Regulatory Factors (GRFs), most frequently Abf1 and Reb1
190 Small molecule-based targeting of chromatin regulatory factors has emerged as a promising therapeuti
191 receptor (MOR) gene two decades ago, various regulatory factors have been shown to interact with the
192 globin scavenging of nitric oxide; these two regulatory factors have not been assessed simultaneously
193 eins, including viral protein R and negative regulatory factor, have effects on adipogenic pathways a
195 ontaminant compromises the function of a key regulatory factor in erythropoiesis, producing effects f
199 ecent evidence of DEL-1 as an exemplar local regulatory factor in the context of tissue immune plasti
202 permidine revealed the interplay of multiple regulatory factors in B. burgdorferi gene expression.
203 ession and association of T-bet, GATA-3, and regulatory factors in CD8(+) T cells isolated from the b
204 ation for understanding the role of multiple regulatory factors in modulating Fshb gene activity.
206 ir that sequesters and mobilizes microtubule regulatory factors in proximity to spindle microtubules.
208 t transcripts for innate and adaptive immune regulatory factors, including IDO-1, arginase-1, Foxp3,
212 O gene, a CDK inhibitor, as a key cell cycle regulatory factor influencing ploidy and cell-size depen
213 tivator of transcription (STAT)-1, IL-6, IFN regulatory factor (IRF) 5, and TLR4 and suppressed c-Jun
215 showed that IRF2, a member of the interferon regulatory factor (IRF) family of transcription factors,
216 clear factor kappa B (NF-kappaB), interferon regulatory factor (IRF), and the signal transducer and a
219 Further experiments identified interferon regulatory factor (IRF)7, a driver of type I IFN, as a p
223 ation of the transcription factor interferon regulatory factor (IRF4), which, along with the environm
224 tive effects of IFN-I require the interferon regulatory factor IRF5, which upregulates genes encoding
225 hway and subsequent activation of interferon regulatory factors (IRFs) 3 and 7, type I interferon, an
226 ignalling, including upregulating interferon regulatory factors (IRFs) and downregulating an inhibito
227 ough host sensory pathways that activate IFN regulatory factors (IRFs) and nuclear factor kappaB.
230 ns, and signal downstream through interferon regulatory factors (IRFs), transcription factors that in
232 that the plasticity accommodated by certain regulatory factors is conserved, despite substantial cha
235 irement for RNAPII pausing and suggest pause regulatory factors may function directly or indirectly t
236 be a novel role for the post-transcriptional regulatory factor Mkt1 in establishment of heterochromat
237 ression thus indicating a role for different regulatory factors modulating expression of the gene.
243 esent study we show that the master myogenic regulatory factor, MYOD1, is a positive modulator of mol
247 enocarcinomas (PDACs) overexpress the myelin regulatory factor (MYRF), an ER membrane-associated tran
248 HFE), fatty acid desaturase 2 (FADS2)/myelin regulatory factor (MYRF), transmembrane protease, serine
249 me3 is erased from the gene loci of myogenic regulatory factors namely MYOD1, MYOG, and MYF5 in diffe
251 NHE3 directly binds Na(+)/H(+) exchanger regulatory factor (NHERF) family scaffolding proteins th
252 moglobin scavenging of nitric oxide as a key regulatory factor of brachial flow-mediated dilatation a
253 datasets: mRNA expression and the associated regulatory factors of miRNA and lncRNA, and ALV gene exp
257 200-nm-sized clusters of enhancer-associated regulatory factors (RFs) at important developmental gene
258 nterplay between RNA polymerase II (Pol II), regulatory factors (RFs), and chromatin, but visualizing
261 robust activation of both NF-kappaB and IFN regulatory factor signaling pathways and the NLRP3 infla
262 hat the ubiquitin ligase Smad ubiquitination regulatory factor (Smurf)1 is a master negative regulato
263 erts mucoprotective effects and that counter-regulatory factors such as dietary iron and luminal lipo
264 LIS1 concentration and the presence of other regulatory factors such as dynactin and may provide new
265 h vessel patterning might involve modulatory regulatory factors such as R-spondin 1 (Rspo1), an extra
267 n factor occupancy data are used to annotate regulatory factors, such as combinatorial transcription
268 system, including recruitment of complement regulatory factors, such as factor H, C4b-binding protei
269 se results indicate that posttranscriptional regulatory factors, such as microRNAs, influence the ass
270 re unique for encoding viral homologs of IFN regulatory factors (termed vIRFs) that can manipulate th
271 ode a unique set of homologs of cellular IFN regulatory factors, termed vIRFs, which are hypothesized
273 ephaly-1 (LIS1) is a highly conserved dynein-regulatory factor that binds directly to the dynein moto
274 -Kinase Anchor Protein (AKAP8) as a splicing regulatory factor that impedes EMT and breast cancer met
275 oint to CGRP as a context-dependent negative regulatory factor that shapes innate lymphocyte response
276 ochondrial fission, Mff and Drp1 also act as regulatory factors that control mitochondrial fission an
279 g the basal level of plasma tPA and identify regulatory factors that control tPA expression by hepato
280 racterization of several recently identified regulatory factors that govern these processes, which ar
282 a conserved 'secondary channel' which binds regulatory factors that modulate transcription initiatio
283 However, the DNA-binding specificity of the regulatory factors that orchestrate specific histone mod
284 MS and AIDP-Wb, we rapidly identify multiple regulatory factors that specifically bind in an allele-i
285 These neurons are subjected to a plethora of regulatory factors that ultimately affect the release of
286 ironmental variation have been observed, the regulatory factors that underlie such mismatches are poo
288 that allows for efficient activation of IFN regulatory factors to drive the antiviral transcriptome.
290 nisms responsible for the targeting of these regulatory factors to specific PM domains requires quant
292 most members of the nine-member GRF (GROWTH REGULATORY FACTOR) transcription factor family are DELLA
293 irus 8 (HHV-8) encodes four viral interferon regulatory factors (vIRFs 1 to 4), all of which are expr
299 MRS) is caused by recessive mutations in the regulatory factor X6 gene (RFX6) and is characterised by
300 d that DNA-dependent activator of interferon regulatory factors/Z-DNA binding protein 1 (DAI/ZBP1) bo