ライフサイエンスコーパス: regulatory sequence

1 gh a canonical DSX-binding site in the Fmo-2 regulatory sequence.

2 ct regions along approximately 600 bp of the regulatory sequence.

3 ression in mammalian organisms directly from regulatory sequence.

4 the formation of an activating or repressive regulatory sequence.

5 the number and type of binding sites in its regulatory sequence.

6 to calculate gene expression levels from DNA regulatory sequence.

7 ations of single-nucleotide polymorphisms at regulatory sequences.

8 A activity in vivo and also identifies novel regulatory sequences.

9 ence of polycomb at a subset of CG-dense cis-regulatory sequences.

10 ly to be the outcome of neutral variation in regulatory sequences.

11 e-scale libraries of systematically designed regulatory sequences.

12 ts ability to confer this property to linked regulatory sequences.

13 hed by transcription factor (TFs) binding to regulatory sequences.

14 actions and the specific genomic position of regulatory sequences.

15 the binding of transcription factors to gene regulatory sequences.

16 ing regions, splicing junctions and splicing regulatory sequences.

17 neocortex may involve the evolution of novel regulatory sequences.

18 utations in splice factors, splice sites, or regulatory sequences.

19 with beta-catenin displaced TCF4 from MMP13 regulatory sequences.

20 vertebrate genomes and the function of human regulatory sequences.

21 pecificity of several of these human-derived regulatory sequences.

22 e binding and functionality of the predicted regulatory sequences.

23 the coordinates of core promoters and other regulatory sequences.

24 nteractions may serve as a marker for active regulatory sequences.

25 NAs with retrotransposons and pseudogenes as regulatory sequences.

26 fications, particularly methylation of their regulatory sequences.

27 rexpress Dyrk1a under the control of its own regulatory sequences.

28 ion in other neurons is mediated by separate regulatory sequences.

29 te TFL1 mimic, even when expressed from TFL1 regulatory sequences.

30 ssion by direct and specific binding to gene regulatory sequences.

31 cilitates interactions between transcription regulatory sequences.

32 nvolve protein-coding genes, as well as gene regulatory sequences.

33 oters, suggesting an overlap with endogenous regulatory sequences.

34 ing SOC1 heterodimers, are able to bind SOC1 regulatory sequences.

35 e H3K9acS10ph and H3K27acS28ph marks at both regulatory sequences.

36 o produce a map of nearly 300,000 murine cis-regulatory sequences.

37 extreme instances of a broader continuum of regulatory sequences.

38 equence conservation and genomic function of regulatory sequences.

39 ent epigenomic marks can be used to discover regulatory sequences.

40 neering cell-type-specific promoters or gene regulatory sequences.

41 nown cases could be caused by alterations in regulatory sequences.

42 modulation exerted by Hox13 paralogs on Gli3 regulatory sequences.

43 degeneration involves evolutionary change in regulatory sequences.

44 recise interactions between genes and distal regulatory sequences.

45 ranscription by blocking access to necessary regulatory sequences.

46 to identify candidate cell type-specific DNA regulatory sequences.

47 ockout contained common features of flanking regulatory sequences.

48 are an abundant and rich genetic resource of regulatory sequences(1-3).

49 sed of Swi4 and Swi6) in the 700-bp upstream regulatory sequence 2 (URS2) promoter region.

50 (TEs) are uniquely equipped to deposit their regulatory sequences across a genome, which could also c

51 t manner and relies on gain/loss of splicing regulatory sequences across the exons.

52 ransposon transcripts, suggesting a class of regulatory sequences acting in trans.

53 this TAD as a functional unit, with several regulatory sequences acting together to elicit a transcr

54 asts within anterior fin rays, whereas hand2 regulatory sequences activated expression in these same

55 RSAT (Regulatory Sequence Analysis Tools) is a modular softwar

56 Using cis-regulatory sequence analysis, STAT5 was identified as a

57 Although developed for regulatory sequence analysis, these methods can be appli

58 tory elements including a stem-cell specific regulatory sequence and an element that drives reporter

59 ral network architectures that integrate cis-regulatory sequence and context-specific expression of t

60 knee injury that is dependent on downstream regulatory sequence and in progenitors is associated wit

61 , the analysis of the role of a specific DNA regulatory sequence and the interacting proteins in the

62 comprehensive understanding of TF binding to regulatory sequences and allows the characterization of

63 Hypomethylation of ZNF423 regulatory sequences and BMP2 signaling result in transa

64 ining 30% of all genes that are enriched for regulatory sequences and depleted for genes involved in

65 se of epigenome maps to delineate human gene regulatory sequences and developmental programs.

66 ually all known experimentally validated cis-regulatory sequences and expose a vast trove of novel el

67 Identify regulatory sequences and gene expression networks that a

68 volutionarily conserved and species-specific regulatory sequences and networks.

69 es that have been played by many plant-viral regulatory sequences and proteins in the creation of pla

70 harbors essential noncoding RNAs, promoters, regulatory sequences and replication origins.

71 We examine changes in constraints on known regulatory sequences and show that for the Rck1/Rck2, Fk

72 as well as the overlaps with exons, putative regulatory sequences and single-nucleotide polymorphisms

73 gene regulation that restrict access to both regulatory sequences and the underlying template.

74 ng of interactions between individual distal regulatory sequences and their target genes.

75 Transcription regulators bind to cis-regulatory sequences and thereby control the expression

76 expression led us to identify SCC25 enriched regulatory sequences and transcription factors (TF) moti

77 Diversifying regulatory sequences and using native microalgal coding

78 The ProxTom transgene contained all Prox1 regulatory sequences and was faithfully expressed in LVs

79 tated open reading frame (Percc1) flanks the regulatory sequence, and the expression of this gene was

80 matin, which harbors potentially active gene regulatory sequences; and bisulfite sequencing (BS-seq)

81 types to identify which particular genes and regulatory sequences are causal.

82 ets and the binding motifs in associated cis-regulatory sequences are dispersed throughout the hierar

83 de-repressing foreign genes-even those whose regulatory sequences are not bound by PhoP.

84 rlap is not coincidental; retrovirus-derived regulatory sequences are often used to control cellular

85 non-coding region, indicating that proximal regulatory sequences are sufficient for HPRT1 expression

86 provide evidence that rearrangements in the regulatory sequences around egr4 and mafb genes may acco

87 work broadens our understanding of splicing regulatory sequences around exons.

88 ll exlBA+ genomes revealed a wide variety of regulatory sequences, as ErfA- and Vfr-binding sites wer

89 ection correlate better with the presence of regulatory sequences, as predicted by the ENCODE Project

90 Our results demonstrate changes in a regulatory sequence associated with a major body plan tr

91 RAs) to test the activity of 2,464 candidate regulatory sequences at all seven time points, we show t

92 ations located in cis-acting transcriptional regulatory sequences at the gene junctions of the genome

93 d, a flexible SVM workflow that predicts new regulatory sequences based on the annotation of known CR

94 Can a single regulatory sequence be shared by two genes undergoing fu

95 , or 'unintelligibility', of orthologous cis-regulatory sequences between Molgula and Ciona.

96 mputational RNA-folding landscape as well as regulatory sequence binding data treated with the same f

97 tations identified create cryptic cis-acting regulatory sequence binding sites that drive aberrant OV

98 ion are associated with the evolution of cis-regulatory sequences, but it is not known how temporal r

99 sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenoty

100 We show that the regulatory sequences, but not other regions of genes exp

101 thought to be tightly coupled to changes in regulatory sequences, but specific molecular events asso

102 hundreds of thousands of tissue-specific cis-regulatory sequences, but the determinants critical to t

103 e-of-the-art performance in identifying gene regulatory sequences, but they have provided limited ins

104 coupled with SpDamID reveals co-targeting of regulatory sequences by Notch and Runx1.

105 etween protein-coding gene promoters and cis-regulatory sequences called enhancers.

106 prinkled throughout the genome are a million regulatory sequences called transcriptional enhancers th

107 ivergence between the X and Y Chromosomes in regulatory sequence can therefore lead to tissue-specifi

108 Our data indicates that ancient conserved regulatory sequences can be tested effectively in transg

109 all at once or extensive engineering of gene regulatory sequences can be used to conditionally activa

110 on variants and rare sequence alterations in regulatory sequences can result in birth defects or pred

111 Specific DNA demethylation of regulatory sequences can result in upregulation of genes

112 tor, followed millions of years later by cis-regulatory sequence changes in the genes of its future r

113 in the methods for discovery of putative cis-regulatory sequences, characterisation of their spatio-t

114 od and combines these with allele frequency, regulatory sequences, chromosomal topological domains, a

115 sed approach to identify frequently used cis-regulatory sequence combinations in the promoter sequenc

116 In addition, with known cis-regulatory sequence combinations, gene function annotati

117 ure of MPRA data to quantify the function of regulatory sequences, compare sequences' activity across

118 developed an algorithm for the detection of regulatory sequence conservation and applied it to phyto

119 guate the mechanisms underlying differential regulatory sequence content across a broad range of phyl

120 to imprinting control regions, the two major regulatory sequences controlled by DNA methylation.

121 and selection have shaped variation in a cis-regulatory sequence controlling gene expression by empir

122 Together, our results identify new regulatory sequences controlling IE1 and IE2 expression

123 The majority of known TE-derived regulatory sequences correspond to relatively ancient in

124 asure the function of thousands of candidate regulatory sequences (CRSs) in a quantitative manner.

125 ional support that AI-TAC is a generalizable regulatory sequence decoder.

126 rthermore, several uncharacterized genes and regulatory sequences demonstrated convergence and thus c

127 HSV-1 contains no such regulatory sequences, demonstrating different mechanisms

128 ion alteration in cancer cells of the distal regulatory sequences described as super-enhancers.

129 inversion of a CTCF site located near these regulatory sequences did not affect transcription of the

130 let us use comparative genomics to identify regulatory sequences directing expression in the DVA int

131 e1, H3K27ac, H3K4me3 and H3K9ac), active cis-regulatory sequences (DNA hypersensitivity sites (DHS)),

132 ression in both mouse injury models required regulatory sequence downstream of Gdf5 coding exons.

133 In BAC transgenic zebrafish, cav1 regulatory sequences drove strong expression in ostensib

134 We identified several potential flanking regulatory sequences, each associated with a subset of d

135 tion at this site is inhibited by a negative regulatory sequence element, and potentially by the H-NS

136 e caused by mutations in splicing signals or regulatory sequence elements, recent studies have noted

137 omoters and enhancers, it is unclear how cis-regulatory sequences encode transcriptional burst kineti

138 s in gene expression due to mutations in cis-regulatory sequences (enhancers).

139 protein (GFP)-KOR1 expressed from its native regulatory sequences established that all eight N-glycos

140 We saw evidence of protein-coding and regulatory sequence evolution as well as the origin of n

141 iversity have revealed the importance of cis-regulatory sequence evolution, few examples exist where

142 ods to infer the evolutionary history of cis-regulatory sequence features, which contribute strongly

143 distantly related ERVs have been exapted as regulatory sequences for many host genes in a wide range

144 sa and nearly each species carries different regulatory sequences for this operon.

145 Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate

146 We further demonstrate how different regulatory sequences give rise to nucleosome-mediated TF

147 duced (Scr) is directed by an unusually long regulatory sequence harboring diverse cis elements and a

148 novel transgenic rodent model in which Zeb2 regulatory sequence has been disrupted, resulting in a p

149 Removing nucleosomes from regulatory sequences has been proposed to play a signifi

150 A large number of cis-regulatory sequences have been annotated in the human ge

151 A large number of putative cis-regulatory sequences have been annotated in the human ge

152 Two cis-regulatory sequences have been identified upstream of th

153 Millions of regulatory sequences have been predicted in the human ge

154 A cis-regulatory sequence here corresponds to a DNA motif boun

155 ty arises from the coordinated action of two regulatory sequences: (i) a WASP homology 2 (WH2) domain

156 therefore identified GARRPR as a novel BF-3 regulatory sequence important for fine-tuning the activi

157 Purified Bil1 bound to the regulatory sequence in Bud6 and triggered NPF effects on

158 t rs2237895 influenced methylation levels of regulatory sequence in fetal pancreas but without demons

159 omission of the transmembrane domain and the regulatory sequence in the canonical 3' untranslated reg

160 nd characterize natural variation in the cis-regulatory sequence in the transcription factor CONSTANS

161 immunoprecipitation, STAT1 bound a putative regulatory sequence in the ULK1 5'-flanking region, the

162 oximately 6.9 kb MIR137/MIR2682 and upstream regulatory sequences in 2,610 SZ cases and 2,611 control

163 ever, comprehensive identification of causal regulatory sequences in brute-force association testing

164 chloroplast genomes, the number of known DNA regulatory sequences in chloroplast genomes are limited.

165 gration, LedPred excels at the prediction of regulatory sequences in Drosophila and mouse datasets co

166 o assess the spatiotemporal activity of Gdf5 regulatory sequences in experimental OA following destab

167 methods to systematically study putative DNA regulatory sequences in intergenic regions near chloropl

168 ap between islet cis-eQTL signals and active regulatory sequences in islets, with reduced eQTL effect

169 d comprehensive identification of functional regulatory sequences in mammalian genomes remains a majo

170 CNS, elucidating the function of non-coding regulatory sequences in neurobiology and linking sequenc

171 sed on the instability and divergence of cis-regulatory sequences in non-recombining genome regions,

172 use genome have yet to be found, and the cis-regulatory sequences in particular are still poorly anno

173 program, as evidenced by induction of gata4 regulatory sequences in regenerating cardiomyocytes.

174 y parallel reporter assay, we identified cis-regulatory sequences in the 3' UTR, including U-rich mot

175 IKE1 (PHL1) were identified to bind to P5CS1 regulatory sequences in the first intron, which carries

176 d discovery and functional assessment of cis-regulatory sequences in the genome.

177 rial ribosomal protein S12 (MRPS12), contain regulatory sequences in their 3'-untranslated region (UT

178 ential of MYC stems from its ability to bind regulatory sequences in thousands of target genes, which

179 We emphasize the use of gene regulatory sequences in viral vectors to target specific

180 ive/repressive function of SMARCA4 at distal regulatory sequences in vivo and support its role in tis

181 show that Hnf1b occupies novel Ngn3 putative regulatory sequences in vivo.

182 e Hamp promoter activity primarily via three regulatory sequences, including an E-box.

183 , revealed MEF2C motif enrichment within cis-regulatory sequences, including neuron-specific promoter

184 e widespread loss of cytosine methylation at regulatory sequences, including promoter regions of prot

185 ion and contains at least three required cis-regulatory sequences, including the 10-bp motif (5'-GAAA

186 ge part, on the activation and repression of regulatory sequences, including transcriptional enhancer

187 ne the positions from which certain intronic regulatory sequences increase mRNA accumulation, the eff

188 Understanding how regulatory sequences interact in the context of chromoso

189 ons, and the other subset subdivides the Scr regulatory sequences into independent enhancer access do

190 n FGF19 (ortholog to mouse Fgf15), including regulatory sequences, into the FRGN mice to create FRGN1

191 ng-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and

192 fic single CpG dinucleotide in the ZAP-70 5' regulatory sequence is a highly predictive and reproduci

193 gene by a fusion-mediated repositioning of a regulatory sequence is much more common than previously

194 Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control of

195 Elucidating the function of highly conserved regulatory sequences is a significant challenge in genom

196 Activation of gata4 regulatory sequences is also prevented by NF-kappaB sign

197 Evolution of gene-regulatory sequences is considered the primary driver of

198 Prediction of gene expression levels from regulatory sequences is one of the major challenges of g

199 ediction of gene expression levels driven by regulatory sequences is pivotal in genomic biology.

200 antitatively predict TF binding to different regulatory sequences is still limited.

201 Although these regulatory sequences likely arose in ancient viruses, th

202 H20 or SLC28A3, suggesting that variation in regulatory sequences may affect expression.

203 Characterization of these five PPARgamma regulatory sequences may enable isolation of the transcr

204 However, these context-specific regulatory sequence models cannot generalize predictions

205 A conserved regulatory sequence module attached to the AAA+ helicase

206 gly appreciated that coding sequences harbor regulatory sequence motifs in addition to encoding for p

207 that distinct epigenetic signatures and cis-regulatory sequence motifs predicted to bind putative co

208 These experiments validated new non-coding regulatory sequences near induced and/or essential genes

209 ke; NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes.

210 represses excitatory cell fate by binding to regulatory sequences near the Tlx1 and Tlx3 genes to sil

211 Finally, we observe that regulatory sequences occur at genomic locations correspo

212 translocate into adjacent cells, bind to the regulatory sequence of Nkx3.1 target genes and impact th

213 Therefore, the 5' regulatory sequence of O. mossambicus glutamine syntheta

214 rent DNA methylation patterns within the cis-regulatory sequence of the agn43 gene turn on or off a f

215 ator-1, and RNA polymerase II binding at the regulatory sequence of the SCNN1A gene and also remarkab

216 atures are likely a result of changes at the regulatory sequence of the target genes.

217 tire coding region and flanking intronic and regulatory sequences of 88 genes and 40 microRNAs associ

218 sed genes are preferentially found in the 5' regulatory sequences of cis-NAT-encoding genes.

219 clude that FCGR3B deletion juxtaposes the 5'-regulatory sequences of FCGR2C with the coding sequence

220 ecific cis-regulatory elements correspond to regulatory sequences of human ENGRAILED-2, PAX-2, and DA

221 Under these conditions, the regulatory sequences of late gene loci were not in close

222 chii, due in part to multiple changes in cis-regulatory sequences of mFAS.

223 line, where eGFP expression is driven by the regulatory sequences of the embryonic betaH1 hemoglobin

224 through hypermethylation of CpG sites in the regulatory sequences of the gene.

225 A heritable polymorphism within regulatory sequences of the LMO1 gene is associated with

226 cate a dynamic association of Prmt5 with the regulatory sequences of the PPARgamma2 gene that facilit

227 BACH2 peaks overlap with BCL6, including cis-regulatory sequences of the PRDM1 gene.

228 ranscription factors for binding to communal regulatory sequences of the target genes, or a combinati

229 Transgenic reporter strains revealed that regulatory sequences of the transcription factor gene al

230 Here, we find that regulatory sequences of tph1b, which encodes an enzyme t

231 targeting of transcription factors (TFs) to regulatory sequences often occluded within nucleosomes.

232 Because regulatory sequences often reside in open chromatin, we

233 The ability to predict the impact of cis-regulatory sequences on gene expression would facilitate

234 Furthermore, by altering the gene regulatory sequences on the Rubisco transgenes, cyanobac

235 wo genes in a DGP potentially share the same regulatory sequence, one might expect that they should b

236 s - for example, through the modification of regulatory sequences or chromatin architecture - can lea

237 beta-glucan content, and suggests that other regulatory sequences or proteins are likely to be involv

238 ent have been identified, the distant-acting regulatory sequences orchestrating their in vivo express

239 Monoallelic expression not due to cis-regulatory sequence polymorphism poses an intriguing pro

240 ) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs).

241 cenarios that reflect real-world multi-label regulatory sequence prediction tasks.

242 on does not involve the IDRS (iron-dependent regulatory sequence) present in the AtFer1 promoter and

243 ed matching of methylation status of the key regulatory sequences (promoters and CpG islands) to expr

244 that amino acid region 1000-1008 of fV is a regulatory sequence protecting the organisms from sponta

245 Genetic lineage tracing systems based on Wt1 regulatory sequences provided evidence that epicardium-d

246 and in the hypertrophic ventricle, involving regulatory sequences proximal to Nppa.

247 's expression pattern through changes at its regulatory sequence, rather than changes at the coding s

248 varphiC31 att site positioned adjacent to a regulatory sequence recognized by Tn3 resolvase.

249 of transcriptional regulators and in the cis-regulatory sequences recognized by these regulators have

250 cific manner, and we identify the set of cis-regulatory sequences recognized by Wor3.

251 III (FNIII)-like domains along with a unique regulatory sequence referred to as the MyBP-C motif or M

252 minants of differences in cis-regulation for regulatory sequences residing in episomes versus chromos

253 Analysis of Id3 regulatory sequences revealed a novel enhancer, located

254 tion by examining the evolution of important regulatory sequences (short linear motifs) in retained d

255 pregnancy; this might be due to variation in regulatory sequences-some of which are progesterone and

256 -NTR tadpoles the myelin basic protein (MBP) regulatory sequences, specific to mature oligodendrocyte

257 is a chromatin feature enriched at gene cis-regulatory sequences such as promoters and enhancers.

258 We show that regulatory sequences sufficient for the epidermal infect

259 , but its NPF effects were masked by a short regulatory sequence, suggesting that additional factors

260 er are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, addit

261 transgenic mice show that the ICR contains a regulatory sequence that activates transcription during

262 hosphoserines in an intrinsically disordered regulatory sequence that integrates cellular signaling a

263 ncers and reveals that they are bifunctional regulatory sequences that also act as gene expression-pr

264 CTCF-binding locations represent regulatory sequences that are highly constrained over th

265 a powerful approach to the investigation of regulatory sequences that can be applied to other cell t

266 Here, we characterize the cis-regulatory sequences that control dsx expression in the

267 of these noncoding regions contain important regulatory sequences that control gene expression.

268 The regulatory sequences that control the expression of such

269 Enhancer elements are genomic regulatory sequences that direct the selective expressio

270 zation elements identified several candidate regulatory sequences that may be responsible for PB-ER t

271 expression is dictated by cell-type specific regulatory sequences that physically organize the struct

272 identify Shh-dependent genes and associated regulatory sequences that promote cochlear duct morphoge

273 cartilage development, SoxE, gained new cis-regulatory sequences that subsequently directed its nove

274 anized genome maintains essential coding and regulatory sequences, the boundaries of IESs must be acc

275 ry protein modularity, conversion of one cis-regulatory sequence to another, distribution of binding

276 sed V. carteri nitrate reductase gene (nitA) regulatory sequences to conditionally express Streptococ

277 us pyogenes Cas9, and V. carteri U6 RNA gene regulatory sequences to constitutively express single-gu

278 ast, modular cloning and accommodate diverse regulatory sequences to drive reagent expression.

279 control of the glycine transporter 2 (GLYT2) regulatory sequences to study for the first time the gly

280 f these ORFs, a single genomic transcription regulatory sequence (TRS) was identified.

281 inuous transcription involving transcription regulatory sequences (TRSs) located in the 5' leader seq

282 creasing our understanding of the process of regulatory sequence turnover.

283 hanism, and maps of hap-ASM and mQTLs reveal regulatory sequences underlying supra- and sub-threshold

284 nt a strategy for dissecting transcriptional regulatory sequences using in vivo methods (massively pa

285 Such maps can nominate regulatory sequence variants that underlie GWAS signals

286 er (gkm-SVM) that encodes cell type-specific regulatory sequence vocabularies.

287 he search of somatosensory specific genes or regulatory sequences, we mapped the H-2Z1 transgene inse

288 CONSTANS-like cis-regulatory sequences were identified proximal to the qE

289 ey murine leukemia virus contains inhibitory/regulatory sequences, which prevent export and mediate n

290 NAs, transcribed bidirectionally from active regulatory sequences, whose expression levels correlate

291 ut the selection of modified transcriptional regulatory sequences with passage facilitated the restor

292 compensation, provided that autosomal trans-regulatory sequences with sex-limited effects are availa

293 lowing us to identify thousands of genes and regulatory sequences with signatures of adaptive evoluti

294 seudoknots that integrate ligand-binding and regulatory sequences within a single folded domain, the

295 nsight into the complexity of Drosophila cis-regulatory sequences within exon-poor regions, we have u

296 ween DNMT3s and TETs at thousands of somatic regulatory sequences within pluripotent cells.

297 egy and used it to interrogate 174 candidate regulatory sequences within the 1-Mbp POU5F1 locus in hu

298 iated from the TAD(cPcdh) fringes toward cis-regulatory sequences within the cPcdh locus, counterbala

299 further demonstrated to bind directly to cis-regulatory sequences within the first intron of CSE to a

300 Regulatory sequences within the gene, which are subject