ライフサイエンスコーパス: regulatory signal

1 ces in order to identify transcriptional DNA regulatory 'signals'.

2 ronmental control and molecular and physical regulatory signals).

3 emaker anterior burster cell for producing a regulatory signal.

4 d driving force or whether it functions as a regulatory signal.

5 o channels as an important posttranslational regulatory signal.

6 eam element, polyadenylation signal and DICE regulatory signal.

7 sion and that limiting glucose in urine is a regulatory signal.

8 highly conserved N terminus of PilA was the regulatory signal.

9 motif of RAG1 functions as a self-initiated regulatory signal.

10 ntly regulate multiple targets and integrate regulatory signals.

11 o developmental, mechanical, and homeostatic regulatory signals.

12 sufficient time for complete degeneration of regulatory signals.

13 sensitivity of the enzyme to other negative regulatory signals.

14 in response to metabolic stress and to other regulatory signals.

15 ing to tryptophan and uncharged tRNA(Trp) as regulatory signals.

16 g for the possibility of a rapid response to regulatory signals.

17 roteins, and are themselves carriers of such regulatory signals.

18 but only CXCR1 mediates cytotoxic and cross-regulatory signals.

19 f complex networked systems driven by hidden regulatory signals.

20 hts are not recognized by the cytochromes as regulatory signals.

21 l regulators important in transducing growth-regulatory signals.

22 rinsically tied to inflammatory and hormonal regulatory signals.

23 l circadian E-Boxes in response to competing regulatory signals.

24 ions, which are thought to typically contain regulatory signals.

25 ology with important applications in finding regulatory signals.

26 function to transmit calcium-dependent cell regulatory signals.

27 subject to regulation by both cis- and trans-regulatory signals.

28 various diversification mechanisms and some regulatory signals.

29 lity of RNA polymerase to respond to various regulatory signals.

30 predict contact counts from one-dimensional regulatory signals.

31 s tumor development by integrating different regulatory signals.

32 tes in response to a diverse range of growth-regulatory signals.

33 otential for responsiveness to physiological regulatory signals.

34 bcellular location and distinct responses to regulatory signals.

35 in the absence of additional cis-acting RNA regulatory signals.

36 patterns of histone modifications and other regulatory signals.

37 , and also serve to integrate diverse growth-regulatory signals.

38 step in a putative cascade of developmental regulatory signals.

39 nt pathway is a source of specialized growth regulatory signals.

40 transcription in response to two cell cycle regulatory signals.

41 rphology changes associated with switches in regulatory signals.

42 ome and the DNA conformation can provide key regulatory signals.

43 apacity of the complex to integrate multiple regulatory signals.

44 odes, indicating the existence of additional regulatory signals.

45 niche, which provides a vital source of HSC regulatory signals.

46 (BRC1) has been proposed to integrate these regulatory signals.

47 Ag-specific T cell responses is governed by regulatory signals.

48 tinguish primary from secondary responses to regulatory signals.

49 lcrum for transmitting mechanical forces and regulatory signals.

50 often change their operation in response to regulatory signals.

51 thesis of several phytohormones and proposed regulatory signals.

52 new antiviral drugs targeting cis-acting RNA regulatory signals.

53 areful balance of both positive and negative regulatory signals.

54 systems have required proteins to propagate regulatory signals.

55 o reduced, suggesting abrogation of negative regulatory signaling.

56 in dynamic state are believed to facilitate regulatory signaling.

57 he data indicate that inhibition of negative regulatory signaling accounts for the amplification of c

58 eans to disseminate captured transcriptional regulatory signals across the genome.

59 ain that is indispensable for LMP-1's growth-regulatory signaling activities.

60 or initiating and temporally maintaining the regulatory signaling activity of a phosphatase.

61 linked chains, which act as a nonproteolytic regulatory signal, adopt an extended conformation that l

62 sented coincidence of this posttranslational regulatory signal and local conformational bias within u

63 developing an elevated set-point of myeloid regulatory signalling and sugar-lipid metabolism with co

64 ability enables it to integrate and transmit regulatory signals and act as a functional, rather than

65 rative genomic approaches: identification of regulatory signals and analysis of the genomic positions

66 parts that serve as the ultimate acceptor of regulatory signals and as the target of inhibitory drugs

67 mmatory stimuli can bypass CD154-CD40 immune regulatory signals and cause activation of autoreactive

68 es, we have used these data to uncover novel regulatory signals and cell type-specific isoforms.

69 e complex RNA structural elements to monitor regulatory signals and control expression of downstream

70 transduction pathways involving NO-mediated regulatory signals and NOSIII activity in human endothel

71 nce they contain a statistical enrichment of regulatory signals and pairs of signals that enable the

72 nts can be configured in tandem to integrate regulatory signals and perform genetic logic.

73 ular function will require interactions with regulatory signals and substrate availability, which bea

74 The transcriptional regulatory signals and the genes that orchestrate this s

75 ent component analysis (ICA), to first infer regulatory signals and then identify biologically releva

76 The goal is to infer knowledge-relevant regulatory signals and then identify corresponding bioma

77 at CI proteins were enriched with essential, regulatory, signaling and disease genes as well as drug

78 i) the phase II response integrates multiple regulatory signals, and (iii), by inhibiting this respon

79 The control of nodes in gene regulatory, signaling, and metabolic networks is governe

80 However, many of the actual regulatory signals are composite patterns that are group

81 Determining how transcriptional regulatory signals are encoded in vertebrate genomes is

82 nges can affect how specific combinations of regulatory signals are mapped to particular gene express

83 The two regulatory signals are nonredundant: changes in iNTP con

84 During cytokinesis, regulatory signals are presumed to emanate from the mito

85 ement, highlighting checkpoints across which regulatory signals are rewired paralleling changes in ce

86 orms with varying boundaries and alternative regulatory signals are transcribed from the genome, even

87 d in our understanding of how these positive regulatory signals are transmitted to the kinase domain.

88 n by batimastat (BB94) showed that different regulatory signals are used by different stimuli and EGF

89 form the rationale for targeting its related regulatory signaling as an anticancer strategy.

90 AS proteins might mediate situation-specific regulatory signaling at the TBP interface and that previ

91 nd cerebellum suggest the presence of unique regulatory signals at these locations that may reflect c

92 We show that activation of the vascular regulatory signalling axis mediated by Norrin (an atypic

93 onal development of bone cells requires that regulatory signals be temporally and spatially ordered.

94 ns, is apparently defective in responding to regulatory signals, because it induces hyperactive initi

95 -functional DNA, while maintaining essential regulatory signals, because of which the content of non-

96 es that emerging research shows can transmit regulatory signals between cells in health and disease.

97 results reinforce the idea that mediation of regulatory signals between cytoplasmic- and membrane-int

98 -activated signaling endosomes that transmit regulatory signals between soma and growth cones.

99 es which help transmit mechanical forces and regulatory signals between the extracellular matrix and

100 provided evidence that this complex mediates regulatory signals between the radial spokes and dynein

101 e CaM- and spoke-associated complex mediates regulatory signals between the radial spokes and dynein

102 induced in this model by B7-driven negative regulatory signaling, but tolerance is maintained by a l

103 reases receptor-induced exocytosis and cross-regulatory signals, but not phosphoinositide hydrolysis

104 positively charged methyl-lysine or create a regulatory signal by allowing or inhibiting binding of o

105 can be configured to directly propagate RNA regulatory signals by constructing an RNA-meditated tran

106 IPH2101 prevents negative regulatory signals by inhibitory KIR, whereas lenalidomi

107 revealed an unexpected utilization of immuno-regulatory signals by pancreatic cancer epithelial cells

108 a identify an orthogonal co-option of immuno-regulatory signals by pancreatic cancer stem cells, sugg

109 romoter platform upon which complex upstream regulatory signals can be integrated, targeting multiple

110 lt of specific protein mutations or aberrant regulatory signals, can be both a cause and an effect of

111 this study, we examined aspects of the Igf1r regulatory signaling cascade in beta cells.

112 Our data define a complex regulatory signaling cascade initiated by LPP and sugges

113 is- and trans-acting elements comprising the regulatory signalling cascade that governs the photobiol

114 HDACs and DUSP5 as integral components of a regulatory signaling circuit that controls cardiac hyper

115 Our results define a regulatory signaling circuit within the innate immune sy

116 dictions about physiological function(s) and regulatory signaling circuits.

117 unit LAMTOR4, revealed the known core mTORC1 regulatory signaling complexes and the intimate interpla

118 Thus, O-GlcNAc is a novel regulatory signaling component of excitatory synapses, w

119 patterns, they often fail to find composite regulatory signals consisting of weak monad parts.

120 imately involved in the transmission of cell regulatory signals controlling proliferation and differe

121 site (TSS), is a major integration-point for regulatory-signals controlling gene-transcription.

122 d may offer a means by which general nuclear regulatory signals could be transmitted to Pol I.

123 Eukaryotic transcriptional regulatory signals, defined as core and activator promot

124 The results of these studies suggest that regulatory signals delivered by the 4-1BB receptor play

125 n exerting both positive and negative growth-regulatory signals, depending on the timing, pathway, or

126 found in 3'-untranslated regions (UTRs) are regulatory signals determining mRNA stability and transl

127 n kinases C (PKC) and may thereby serve as a regulatory signal during cell stimulation.

128 that L-arginine availability functions as a regulatory signal during Legionella intracellular growth

129 fected cells are impaired by higher negative regulatory signals during modified avian influenza virus

130 Our data suggest that BAFF may be providing regulatory signals during specific T cell-independent ev

131 usly known as the ultimate recipients of cdk regulatory signals, E2F4/5 and p107 act here as transduc

132 Regulatory signals feed into the system through post-tra

133 Here, we identify the target and the regulatory signal for a c-di-GMP-responsive Escherichia

134 lasma membrane or serves as an intracellular regulatory signal for differentiation of immature hair c

135 ycle of Cool-1 at Tyr-442 can serve as a key regulatory signal for focal complex assembly-disassembly

136 on in the genome also serves as an important regulatory signal for many biological processes and its

137 e that ligation of CD137 receptor delivers a regulatory signal for T-cell anergy and implicate manipu

138 ement for almost every organism, serves as a regulatory signal for the expression of virulence determ

139 interaction with self-antigen and resultant regulatory signaling for its maintenance.

140 This environment provides key regulatory signals for and tightly controls cardinal fea

141 key sensing mechanism to generate downstream regulatory signals for cell growth and differentiation.

142 Hematopoietic stem cells receive the regulatory signals for cell production in adult mammals

143 nning tyrosine kinase receptors that mediate regulatory signals for cell proliferation and differenti

144 essenger, cAMP, is one of the most important regulatory signals for control of steroidogenesis.

145 elp develop strategies targeting CAP1 or its regulatory signals for controlling the invasive cycle of

146 hese sequences that may serve as controls or regulatory signals for gene expression.

147 CXCR1-, CCR5-, and DeltaCXCR2-mediated cross-regulatory signals for GTPase activity, Ca(2+) mobilizat

148 ole of SepJ in the intercellular transfer of regulatory signals for heterocyst differentiation.

149 evolved to integrate several protein kinase regulatory signals for progression through S phase.

150 with B7 expressed by APCs generates critical regulatory signals for T cell activation.

151 rate of CoA biosynthesis to be controlled by regulatory signals from CoA thioesters involved in diffe

152 to deduce bipartite network connectivity and regulatory signals from data without any need for prior

153 However, how distinct positive and negative regulatory signals from immune receptors are integrated

154 rk component analysis, for uncovering hidden regulatory signals from outputs of networked systems, wh

155 proteins in the nodes, and receives negative regulatory signals from Pom1.

156 AGI-1 may participate in the transmission of regulatory signals from the cell surface to the nucleus.

157 Intestinal immune regulatory signals govern gut homeostasis.

158 tion approaches that aim to estimate missing regulatory signals have been applied before genome segme

159 odel of neural development, in which several regulatory signals have been identified.

160 d G1/S/G2/M phases and respond adaptively to regulatory signals; however the nature of the robustness

161 Monoubiquitination serves as a regulatory signal in a variety of cellular processes.

162 e results suggest that Notch1 provides a key regulatory signal in determining T lymphoid versus B lym

163 the risk for candidiasis, and MG serves as a regulatory signal in diverse organisms.

164 odification of histones has emerged as a key regulatory signal in eukaryotic gene expression.

165 downstream coding sequence in response to a regulatory signal in the absence of a trans-acting prote

166 Moreover, data suggest NO pathway as a key regulatory signaling in AMPA-induced Src activation in n

167 onfiguration with altered NF-kappaB and TATA regulatory signals in contradistinction with HIV-1B.

168 nd/or the presence of mechanisms to separate regulatory signals in different tissues.

169 cturally altered DNA elements might serve as regulatory signals in gene expression or in telomere dyn

170 actor binding sites (TFBSs) encoding complex regulatory signals in metazoan genomes remains a challen

171 method will be useful for the extraction of regulatory signals in multiple genomes.

172 o define, at the molecular level, the growth-regulatory signals in neoplastic cells that are associat

173 isoprenyl phosphates (PIPPs) as natural down-regulatory signals in neutrophils.

174 apoptosis might result from aberrant growth regulatory signals in non-aggregated, cycling cells.

175 diverse array of conformations to respond to regulatory signals in signaling pathways.

176 ine-threonine kinases that mediate important regulatory signals in the cell.

177 tion with DNA, VP16 is able to interpret cis-regulatory signals in the DNA to direct the assembly of

178 y comes under the influence of extracellular regulatory signals in the form of hematopoietic cytokine

179 0 by CKII and PKC are determined by distinct regulatory signals in vivo.

180 Disorders that disturb ubiquitin regulatory signaling include at least two subtypes of Fa

181 s and aligned them with developmentally cued regulatory signaling including IL-7/STAT5 and cellular e

182 GATA FACTOR1 is controlled by several growth regulatory signals including light and the phytohormones

183 to the abrogation of various negative growth regulatory signals, including a p53-mediated G1 growth a

184 that can involve multiple mechanisms and cis-regulatory signals, including a role for RNA splice site

185 (NG2 cells) are exposed to various extrinsic regulatory signals, including the neurotransmitter GABA.

186 hese results suggest that distinct extrinsic regulatory signals influence the expression of synapse-r

187 evidence that endogenous RA acts as a major regulatory signal integrating Wnt and Tgfbeta pathways i

188 translates both maternal and early embryonic regulatory signals into spatial distribution of transcri

189 mechanism whereby plants incorporate diverse regulatory signals into the developmental programme of L

190 Little is known about the regulatory signals involved in tendon and ligament forma

191 tg1p.Rtg3p complex, yet the precise upstream regulatory signals involved remain unclear.

192 This indicates that evolution of cis-regulatory signals is a major contributor to the emergen

193 AAVs), delivery of genes encoding microglial regulatory signals led to the identification of AAV sero

194 Monoubiquitylation is a regulatory signal, like phosphorylation, that can alter

195 Though it is a target for multiple regulatory signals, little is known about the dynamics/t

196 rovide mechanistic insight into an autocrine regulatory signaling loop that regulates beige adipocyte

197 Thus, transcription regulatory signals may serve as "punctuation marks" for

198 Furthermore, our study identifies a self-regulatory signaling mechanism from CARM1's catalytic do

199 gnaling as a novel thin filament contractile regulatory signaling mechanism.

200 nation of cis- and transacting secretory and regulatory signals, micromolar secretion levels of the a

201 h as WNT-beta-catenin signalling, cell cycle regulatory signalling, mitogen-activated protein kinase

202 ation in the expression and translocation of regulatory signaling molecules in membrane domains of B

203 le checkpoint, the production of conflicting regulatory signaling molecules induces apoptosis in canc

204 nchoring protein, suggesting that additional regulatory signals must be required to release active en

205 r receptors (TNFRs) and their ligands form a regulatory signaling network that controls immune respon

206 tween genes within this signature revealed a regulatory signalling network consistent with a model of

207 Further integration of multiple regulatory signaling networks, involving regulators such

208 ages, we construct cellular interactomes and regulatory signaling networks.

209 Mucosal immunity depends on regulatory signals; nutritional elements, including fats

210 ting cellular responses only when convergent regulatory signals occur close in time.

211 For differentially regulated DGPs, the regulatory signal of one gene can stochastically 'leak'

212 rboxylate fuel, and that cellular sources of regulatory signaling of lactate utilization exist within

213 glucose substrate imbalance are initiated by regulatory signals of periventricular origin.

214 ) exclusively mediates chemotactic and cross-regulatory signals of the PAFR, but both G(i) and G(q) a

215 e a foundation for investigating the role of regulatory signals on the stability of this interface.

216 ar checkpoint for DNA loading in response to regulatory signals or antibiotics.

217 ons that encode protein interaction domains, regulatory signals, or translation initiation or termina

218 ma cells remain sensitive to negative growth regulatory signals originating from fibrillar collagen,

219 interacts with RTA at the protein abundance regulatory signal (PARS) motifs, and the association pre

220 econd regulatory region, a protein abundance regulatory signal (PARS), consists of two components.

221 uliar structural features and uncovers a new regulatory signaling path distinct from the MAPK signali

222 Therefore, we define a regulatory signaling pathway mediated by Barkor that pos

223 r coordinating protein synthesis and diverse regulatory signal pathways.

224 nt Cl(-) secretion through multiple negative regulatory signaling pathways and inhibition of specific

225 proliferation by interacting with key growth regulatory signaling pathways and the translation proces

226 However, little is known about the regulatory signaling pathways in brain pericytes.

227 p7a1 proximal promoter and the expression of regulatory signaling pathways in postpartum rats at day

228 Additionally, the activation of counter-regulatory signaling pathways leads to chronic metabolic

229 ial raft redistribution and whether negative regulatory signaling pathways target this phase of cellu

230 As two major regulatory signaling pathways that regulate epidermal ho

231 Mutants fail to activate two important regulatory signaling pathways, mediated by phosphatidyli

232 rmal growth factor receptor and other growth regulatory signaling pathways.

233 By better understanding these immune-regulatory signalling pathways, new therapeutic strategi

234 Here we show that the pocket integrates two regulatory signals, phosphorylation and ligand binding,

235 We identify two cell cycle regulatory signals, ppGpp and polyphosphate (polyP), tha

236 f these genes increases our understanding of regulatory signals present in human urine, blood, and as

237 nd is dynamic enough to serve as a nitrative regulatory signaling process that likely affects cellula

238 We propose that miR-9 links regulatory signaling processes with dynamic translation

239 e expressions of GPCRs, and their downstream regulatory signaling proteins (regulator of G-protein si

240 Regulatory signals provide negative input to immunologic

241 ns and leukotrienes, are balanced by counter-regulatory signals provided by a class of molecules call

242 ly determined by intrinsic properties and by regulatory signals provided by the microenvironment.

243 regulated by inherent programs and extrinsic regulatory signals received from their microenvironmenta

244 troyed by the ablation and that unidentified regulatory signals released in response to localized dam

245 nse has been largely attributed to providing regulatory signals required for the priming of major his

246 ereby cellular loading could activate growth regulatory signals responsible for cardiac hypertrophy.

247 s may be controlled at some level by similar regulatory signal(s).

248 ion of the LCV and the identification of the regulatory signals sensed during intracellular replicati

249 ly affects synonymous sites, suggesting that regulatory signals significantly constrain synonymous su

250 which viral inhibition is activated by viral regulatory signals such as defective-interfering particl

251 dent sites are not predicted by pre-existing regulatory signals, suggesting that Cdx2 can bind to a s

252 We have used these mutants to determine the regulatory signal that allows ATP to bind to the forward

253 h an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-

254 pha-chain signal peptide contains a negative regulatory signal that prevents expression of an immunor

255 nely tuned by multiple positive and negative regulatory signals that appropriately scale the magnitud

256 However, typical graph metrics ignore regulatory signals that are crucially important for opti

257 mRNA 3'-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mR

258 a platform for multiple DNA damage-dependent regulatory signals that control DNA replication.

259 amic structures that are apparent targets of regulatory signals that control the function of focal ad

260 unctional actin cytoskeleton and transducing regulatory signals that control the paracellular barrier

261 on as a sensor, integrator, and processor of regulatory signals that converge on protein-coding gene

262 The models account for known regulatory signals that exert control over the pathway.

263 y heterogeneous and provide multiple complex regulatory signals that have the potential to enhance or

264 , perhaps through the endocytosis of unknown regulatory signals that organize morphogenesis at synapt

265 3-kinase (PI3K)-Akt pathway transmits growth-regulatory signals that play a central role in promoting

266 interaction between extrinsic and intrinsic regulatory signals that regulate the myogenic process.

267 Here, we have dissected the regulatory signals that repress the expression of the st

268 t melanoma cells remain responsive to growth regulatory signals that result from contact with type I

269 pA bind to the C-type lectin SIGNR3 to exert regulatory signals that result in mitigation of colitis,

270 ring transposons to carry reporter genes and regulatory signals, the expression of target genes can b

271 ps of Hoxd genes respond first to a proximal regulatory signal, then to a distal signal that organize

272 in a genome in which they are surrounded by regulatory signals they must ignore.

273 ed inhibitory motifs that transduce negative regulatory signals through the cell membrane are found i

274 example, the interferon receptors transduce regulatory signals through the JAK/STAT pathway, resulti

275 Glutamine synthetase transmits the nitrogen regulatory signal to GlnR.

276 ass of regulators, a protein that transduces regulatory signals to a separable core motor machinery.

277 APCs provide costimulatory and down-regulatory signals to Ag-activated T cells through inter

278 l conditions and allow DNA sequence-mediated regulatory signals to be communicated to the active site

279 mmune cells to bacterial components provides regulatory signals to cognate immune cells.

280 uginosa, the GacS/GacA system transduces the regulatory signals to downstream genes exclusively by di

281 l protein kinase C isoforms (aPKCs) transmit regulatory signals to effector proteins located in the c

282 rces of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virul

283 re than simple tethering devices and mediate regulatory signals to the host protein.

284 Thus, SE could potentially deliver regulatory signals to the recipient mucosa via transfer

285 al role of the Mediator complex in conveying regulatory signals to the transcriptional apparatus.

286 the intracellular domain, including the key regulatory signal transduction elements and all of the c

287 suggested that they may be activating growth-regulatory signal transduction pathways.

288 ty of PPs is epigenetic modulation of growth-regulatory signal transduction pathways.

289 However, the regulatory signal transduction processes that control sC

290 quently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a

291 le for activation of the MtrAB two-component regulatory signal transduction system, which includes se

292 is and Escherichia coli respond to identical regulatory signals, tryptophan and uncharged tRNA(Trp),

293 different cellular events, but that distinct regulatory signals ultimately control when and where unl

294 Ss, which have highlighted the importance of regulatory signals versus coding variation.

295 ytes by providing both positive and negative regulatory signals via multiple signaling pathways invol

296 e circumstances might be to provide negative regulatory signals via the CD28 homologue CTLA-4.

297 sponse of ectomesenchyme cells to epithelial regulatory signals was found to be different in the mand

298 e first exon of BTK contains transcriptional regulatory signals, we tested various portions of the se

299 icipate in previously unanticipated roles as regulatory signals with hormone-like functions.

300 atory RNA elements to specifically sense the regulatory signal, without accessory components, and con