ライフサイエンスコーパス: regulatory site

1 at vMIA contacts Bax at a previously unknown regulatory site.

2 a coli PabB, binds tryptophan in a vestigial regulatory site.

3 nding domain and the absence of metal in the regulatory site.

4 identify the basic patch on CP as a crucial regulatory site.

5 -Gly-NH2 at the dopamine receptor allosteric regulatory site.

6 ression was correlated with oxidation of the regulatory site.

7 states, it is unexpectedly different at the regulatory site.

8 bioactive lipids from a critical allosteric regulatory site.

9 ence of a previously unidentified allosteric regulatory site.

10 de repeat domain at a special class of Notch-regulatory sites.

11 (Mcidas, Rfx2, and Myb) with distinct Grhl2 regulatory sites.

12 ontrol of alternative splicing at cis-acting regulatory sites.

13 e previously identified dGTP-binding primary regulatory sites.

14 d with inflammatory changes in thalamic pain regulatory sites.

15 assign priority to a list of candidate MAPK regulatory sites.

16 that these sites were not the physiological regulatory sites.

17 opening at male-biased but not female-biased regulatory sites.

18 GTP/GDP and the absence of known allosteric regulatory sites.

19 ion of genes containing activation protein-1 regulatory sites.

20 w opportunities for gene control by TE-based regulatory sites.

21 e activities to ERG/FLI1 bound hematopoietic regulatory sites.

22 eved by at least two strategies for exposing regulatory sites.

23 that comprehensively mark cell-type-specific regulatory sites.

24 ic S129 site and the canonical S473 and T308 regulatory sites.

25 ated intestine and its ability to bind these regulatory sites.

26 moters, regardless of the arrangement of cis-regulatory sites.

27 protein expression due to the loss of miRNA regulatory sites.

28 ly de rigeur for the identification of novel regulatory sites.

29 netic memory and gene regulation from distal regulatory sites.

30 ted to elongating RNA polymerase at specific regulatory sites.

31 h transcription factors (TFs) bind their DNA regulatory sites.

32 s human FOXO3 at six previously unidentified regulatory sites.

33 specific binding of REX1 to these chromatin regulatory sites.

34 chromatin remodeling at distal and proximal regulatory sites.

35 mapping robustly predicted functional miR-17 regulatory sites.

36 ) allows transcriptome-wide discovery of RNA regulatory sites.

37 ngs between transcriptional factors and gene regulatory sites.

38 cription start site (TSS) regions and remote regulatory sites.

39 t mediates kinase dimerization, as potential regulatory sites.

40 nd migration, regains phosphorylation at its regulatory sites.

41 identifies transcription-coupled accessible regulatory sites.

42 tionary losses/gains and massive rewiring of regulatory sites.

43 r clusters, allowing robust contacts between regulatory sites.

44 evealed a previously unrecognized allosteric regulatory site 25 A from the active site.

45 th increased phosphorylation of the negative regulatory site 292 on Zap70 and a decrease in granzyme

46 (well below the concentration of TNC Ca(2+) regulatory sites, 67.6 mumol kg(-1)).

47 igenetic signature of thousands of potential regulatory sites across the genome.

48 tide polymorphism rs8050136 (located in this regulatory site) affects binding affinities of P200 and

49 aptamer most likely binds to the receptor's regulatory site and inhibits it noncompetitively.

50 (3) Propionylphosphinate also binds at the regulatory site and its binding is reflected by catalyti

51 R interact with the clathrin light chain EED regulatory site and stimulate clathrin lattice assembly.

52 G4s play key roles as DNA regulatory sites and as kinetic traps that can inhibit b

53 and +6 mL/mol for the calcium binding to the regulatory sites and closed to open protein isomerizatio

54 olve fluctuations both in occupancies of DNA regulatory sites and copy numbers of protein products.

55 They are among the first factors to bind key regulatory sites and facilitate chromatin opening.

56 ramer contains four dGTP specific allosteric regulatory sites and four active sites.

57 HMGN proteins localize to chromatin regulatory sites and modulate the cell-type specific tra

58 tor specificity, improving identification of regulatory sites and reconstructing regulatory interacti

59 Here, we review the importance of these regulatory sites and what role they may play in the disr

60 is controlled by the presence of iron in the regulatory site, and iron-catalyzed oxidation of PerR by

61 e importance of its effects on gluconeogenic regulatory sites, and 3) to correlate those changes with

62 egrity in cognition, anxiety, and depression regulatory sites, and their associations with these func

63 oxide could specifically oxidize APSK at its regulatory site, APSK was irradiated in the presence of

64 ipate in each other's regulation and distant regulatory sites are in communication with each other.

65 termine the organization of chromatin around regulatory sites are not fully known.

66 ve to Ca(2+) regulation, suggesting that the regulatory sites are not intrinsic to the channel protei

67 e genome background, amino acid and putative regulatory sites are not significantly enriched in allel

68 The identified regulatory sites are present in mammalian Musashi protei

69 DNaseI-seq identified putative regulatory sites around genes enriched in Sertoli and pr

70 Our results suggest the creation of miRNA regulatory sites as a novel function for ADAR activity.

71 rinsic to the mobilized vesicles and a novel regulatory site at the fusion pore itself.

72 tus in normal cells points to locally active regulatory sites at super-enhancers, which are targeted

73 h which nucleosomes form in regions flanking regulatory sites before induction, and the extent of the

74 Pausing at these regulatory sites blocks the formation of alternate struc

75 Super-enhancers are clusters of gene-regulatory sites bound by multiple transcription factors

76 ting autophosphorylation of the tyrosine-831 regulatory site by site-directed mutagenesis enhances sh

77 alities in variant burden on tissue-specific regulatory sites by calculating the enrichment of allerg

78 To test this, we determined the number of regulatory sites by measuring the concentration of tropo

79 ryo-EM) showed that engagement of both eIF2B regulatory sites by two eIF2(alphaP) molecules remodels

80 Regulatory site Ca(2+) binding altered dynamic propertie

81 To investigate this process, regulatory site Ca(2+) binding in the NH(2)-lobe of subu

82 ings demonstrate highly selective effects of regulatory site Ca(2+), including opposite changes in pr

83 Vice versa, the presence of regulatory sites can promote the phase-separation proces

84 metalloprotease 9) via its redox-responsive regulatory sites, causing a cascade of molecular events

85 e in response to 1,25D revealed a cluster of regulatory sites (cis-regulatory module; CRM) at -28 kb

86 motrypsins and elastases are inactive on the regulatory sites cleaved by CTRC, suggesting that CTRC r

87 How these regulatory sites communicate with catalytic residues is

88 This regulation occurs via a single AATAAATA regulatory site (conserved in the mouse) within the FTO

89 strongest transcriptional effects are on cis-regulatory sites containing the RORalpha binding motif.

90 Notably, some regulatory sites control the kinetic rather than the ove

91 Unexpectedly, rearranging sparkling's regulatory sites converts it into a robust photoreceptor

92 Using BBLS, we predict 1.5 million regulatory sites, corresponding to 380 known regulatory

93 While substitutions at the different Ca(2+)-regulatory sites could either slightly enhance or marked

94 The 'Regulatory sites' dataset includes curated information a

95 The environment at the regulatory site dictates the charge and the structural c

96 inding to a previously unidentified specific regulatory site distal to the Ifnb1 promoter.

97 These dynamic changes in functional regulatory sites, distal to the imatinib binding pocket,

98 To identify regulatory sites during sex determination, we subjected

99 ell imaging data measuring distances between regulatory sites during time is also discussed.

100 stem AIKYATAN, we annotate distal epigenomic regulatory sites, e.g., enhancers.

101 Because binding to regulatory sites enables activators to stimulate transcr

102 d NF-kappaB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosi

103 ities, and serum assays demonstrate that the regulatory site extends domains 1-4 and includes domains

104 ; abdominal fat emerged as an important gene-regulatory site for blood lipids, such as for the low-de

105 ancies, indicating this site as an important regulatory site for hematopoiesis.

106 The presence of a regulatory site for monovalent cations that affects the

107 ays, and also reveals a potential functional regulatory site for RPTPgamma.

108 membrane conductance regulator as a critical regulatory site for S1P signaling; its tumor necrosis fa

109 ively, our results identify Y1494 as a major regulatory site for signaling from the alpha6beta4 integ

110 onserved steroid binding site could reveal a regulatory site for steroids or structurally related mol

111 ated in the VRN1 promoter is the most likely regulatory site for the interaction with this second rep

112 ot used as a substrate, Na(+)-NQR contains a regulatory site for this ion, which acts as a nonessenti

113 enetic data implicating this domain as a key regulatory site for tuning stimulus sensitivity.

114 However, critical regulatory sites for Afp activation, overlapping Foxa1/p

115 ve not been considered because no allosteric regulatory sites for PINK1 are known.

116 gly phases flanking nucleosomes and presents regulatory sites for ready access.

117 located in intergenic regions that comprise regulatory sites for TFs or miRNA.

118 ch intriguingly also accommodate binding and regulatory sites for the key complement activation-speci

119 re mRNA allelic imbalances associated with a regulatory site found in mRNA transcribed from one allel

120 re, variants that affect chromatin at distal regulatory sites frequently also direct changes in chrom

121 Nonetheless, distinguishing regulatory sites from among the thousands identified by

122 structural transitions and could distinguish regulatory sites from nonfunctional conserved residues.

123 e cerebellum increases accessibility of gene regulatory sites genome-wide in vivo.

124 Phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both

125 ruitment in mammals remain unclear since few regulatory sites have been identified.

126 quent to removal of the calcium ion from the regulatory sites I and II.

127 ilitating genome-wide chromatin dynamics and regulatory site identification in C. elegans.

128 stimulate eNOS phosphorylation at a critical regulatory site, (ii) increase eNOS activity, and (iii)

129 urrence of surface pockets at the active and regulatory sites; ii) a simulated ensemble of unliganded

130 actors (TFs) assemble at tissue-specific cis-regulatory sites, implying that different TF combination

131 ong the first detailed analyses of a complex regulatory site in a GPCR, and provides insight into GPC

132 FHL-1 is the observation that the complement regulatory site in FH exceeds the established first four

133 lates VDAC and that VDAC may be an important regulatory site in ischemia/reperfusion injury.

134 horylation at serine residue 536, a critical regulatory site in its transactivating domain.

135 An apparently equivalent PKC regulatory site in metabotropic glutamate receptor 5 (Se

136 ts 5-coordinate NO-binding capability to the regulatory site in soluble guanylate cyclase.

137 P response element (CRE) is a major positive regulatory site in the bcl-2 promoter.

138 tation (ChIP) confirmed binding of ATF4 to a regulatory site in the VEGF gene.

139 t-transcriptionally repress mRNA through cis-regulatory sites in 3' UTRs.

140 eferentially targets female-biased genes and regulatory sites in a sex-independent chromatin state.

141 en receptor alpha binding to transcriptional regulatory sites in breast cancer cells.

142 ovides insight into mechanisms that maintain regulatory sites in chromatin and into functional compen

143 to form part of NF-kappaB bound to specific regulatory sites in chromatin.

144 operate differently through the same 3' cis-regulatory sites in distinct populations of retinal prog

145 iments identified Ser-413 and Ser-424 as key regulatory sites in IRF6.

146 encing to produce condition-specific maps of regulatory sites in male and female mouse livers and in

147 ed by FOXO3 when phosphorylated at these six regulatory sites in mammalian cells.

148 ily be applied to mapping condition-specific regulatory sites in mammalian tissues under a wide varie

149 ural analysis indicates that, binding to the regulatory sites in proximity of the antenna region, NAD

150 ls access to ribosome binding sites or other regulatory sites in RNA.

151 ) transport through the channel, feeding the regulatory sites in the cytoplasmic domain.

152 m Tcf3 without inhibiting its binding to cis-regulatory sites in the DNA.

153 Little is known about the nature of AR cis-regulatory sites in the human genome.

154 etics to study an entire layer of short, cis-regulatory sites in the human genome.

155 To identify regulatory sites in the murine c-myb upstream region, we

156 s, we show that Nek2 phosphorylates the same regulatory sites in the N-terminus of beta-catenin as gl

157 Evi1 binds with C/EBPbeta to regulatory sites in the Ppargamma locus at early stages

158 Variants at regulatory sites in the promoter and intronic regions le

159 while cellulases are controlled by different regulatory sites in three organisms.

160 identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular

161 transcription factors to promoters and other regulatory sites in vivo.

162 high affinity site in two conserved Sostdc1 regulatory sites in vivo.

163 CLAM recovered a large number of novel RNA regulatory sites inaccessible by uniquely mapped reads.

164 Mutated regulatory sites include known sites in the TERT promote

165 s GC-rich, and harbored several putative cis-regulatory sites including KLFs, AP-2, EGRF and Sp-1.

166 The accessible regions contain functional regulatory sites, including promoters, insulators and en

167 -1903 of IP3R1) that is adjacent to numerous regulatory sites, including sites for proteolysis.

168 Furthermore, EBF1 binding to Gata3 regulatory sites induced repressive histone modification

169 development of specific substrate active- or regulatory-site inhibitors with therapeutic potential.

170 quilibrium dissociation constant of a single regulatory site is 8 mM for K(+).

171 ability of miR-155 to interact with the cis-regulatory site is decreased.

172 This regulatory site is homologous to the serine 298 in perch

173 The novel upstream regulatory site is important for the maturation of sever

174 c factor Srf (serum response factor) to Egr1 regulatory sites is dependent on Bptf function.

175 e information encoded by combinations of cis-regulatory sites is interpreted primarily through simple

176 Metal binding to regulatory sites is through a reversible metal exchange

177 t subsequently binds to UAS2 (a critical cis-regulatory site located approximately 600 base pairs dow

178 transcriptional activators, which work from regulatory sites located between the divergently transcr

179 tream of the TSS, as well as at a cluster of regulatory sites located even further upstream between -

180 pamine-stimulated phosphorylation of Cx36 at regulatory sites, mediated by protein kinase A.

181 and nuclear factor kappaB (NFkappaB) as key regulatory sites mediating the induction of sPLA(2).

182 tion by binding to partial complementary cis-regulatory sites (miRNA binding sites) in their target m

183 ed by the alpha2 helix dividing two distinct regulatory sites: Na(+) and the inhibitory peptide.

184 BF-3 is a previously unrecognized allosteric regulatory site needed for AR activity in vivo and a pos

185 ranscriptional level but neither the AP1/Ets regulatory sites nor the redox sensitive (-1607/2G) site

186 et genes in both species, occurred at distal regulatory sites not promoters, and were strongly enrich

187 stimate that a typical gene harbors 7-15 cis-regulatory sites (nucleotides) at which a selectively ne

188 Mutations in the upstream regulatory site of ADAM17, ADAM10, and ADAM9 do not prev

189 roid pregnenolone sulfate, or the allosteric regulatory site of benzodiazepines/beta-carbolines.

190 free Cu ion and the BCB may serve as a main regulatory site of Cu in the CSF.

191 To address this, we targeted the regulatory site of ERAP1 using a high-throughput screen

192 y an RNA-binding patch within the allosteric regulatory site of human and mouse PRC2, adjacent to the

193 tagenesis showed that serine 1935 is a major regulatory site of NMII-B function.

194 gree, by dephosphorylation of Tyr(P)(346), a regulatory site of Syk, which becomes phosphorylated soo

195 ysis confirmed that the compound targets the regulatory site of the enzyme that normally binds the C-

196 ate requires the binding of a coagonist to a regulatory site of the receptor.

197 Pathogen-mediated selection often targeted regulatory sites of genes belonging to the same biologic

198 We found FXR to bind to regulatory sites of genes encoding these proteins in con

199 Whereas PTF1-L bound regulatory sites of genes in normal adult pancreatic cel

200 pecific expression, and to identify putative regulatory sites of membrane transport proteins.

201 To identify the regulatory sites of phosphorylation under physiologicall

202 lower change requires Ca(2+) binding to both regulatory sites of sTnC.

203 ccupy both overlapping and exclusive genomic regulatory sites of target genes and also control the tr

204 t, blocking catalysis without disrupting the regulatory sites of the enzyme does not affect filament

205 is less efficient in dephosphorylating other regulatory sites of this kinase.

206 However, occupancy of the transcriptional regulatory site on DNA by BirA is exquisitely tuned by t

207 ructure-based validation of a new allosteric regulatory site on Ras that is targetable in a mutant-sp

208 efects despite phosphorylation of a negative regulatory site on SLP-76 by HPK1, a function that is lo

209 escaped attention, including a potential new regulatory site on the opposite face to that involved in

210 tyrosine kinase whose target is the Src-SH2 regulatory site on the phospholipase C [PLC] complex.

211 PDGFA, by inhibiting its occupancy at a key regulatory site on the proximal PDGFA promoter.

212 phosphorylate the essential activation loop regulatory site on these kinases.

213 ivity, which prevents the phosphorylation of regulatory sites on C/EBPbeta.

214 Mechanistically, Evx1as RNA binds to regulatory sites on chromatin, promotes an active chroma

215 Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as

216 inations of splicing factors interact at cis regulatory sites on pre-mRNA transcripts.

217 modes, suggesting the presence of allosteric regulatory sites on the enzyme.

218 Sleep deprivation affects phosphorylation of regulatory sites on the kinase, suggesting a role for SI

219 ed to target a nitro group to redox-mediated regulatory sites on the receptor.

220 tants of the reaction between Ca(2+) and the regulatory sites on troponin; values of 0.4 x 10(8) m(-1

221 e allows users to search the database with a regulatory site or matrix to identify the TFs most likel

222 th residue 159 contributing to an anesthetic regulatory site or sites, and they suggest that volatile

223 pression include somatic mutations in splice regulatory sites or altered splicing factors.

224 observed a DNV burden in RNA-binding-protein regulatory sites (OR = 1.13, 95% CI 1.1-1.2, P = 8.8 x 1

225 Knowledge of regulatory sites outside the active and effector sites a

226 ng among the three sites, and (3) complement regulatory sites overlap with each of the three heparin

227 ich binds with negative cooperativity to two regulatory sites per dimer to form, sequentially, Zur2:Z

228 the structural transitions occurring at this regulatory site, potentially altering transcription fact

229 r signaling pathway, possesses an allosteric regulatory site previously validated both in vitro and i

230 DNA-binding transcription factor and its cis-regulatory site, reminiscent of the coevolution of prote

231 ontains mitogen-activated kinase (MAPK)-like regulatory sites, responsible for MAPK inhibitor-sensiti

232 te-binding domain and that abolishing either regulatory site results in loss of Ssa1 interaction.

233 The interaction between calcium and the regulatory site(s) of striated muscle regulatory protein

234 stimulation also provoked phosphorylation of regulatory site Ser(916) on PKD.

235 e JNK can phosphorylate IRS1 on the negative regulatory site Ser-307.

236 ntially regulated Akt phosphorylation of the regulatory sites Ser-473 and Thr-450 and the catalytic T

237 This study reports how phosphorylation of a regulatory site (Ser-500) integrates with Ca(2+) and CaM

238 quires the phosphorylation of p53 at the key regulatory site, Ser15.

239 nteraction of NsrR with an A+T-rich class II regulatory site showed relaxed sequence specificity.

240 Mutational analysis of the regulatory site showed that the PerR metal ligands are i

241 Here we report identification of an Na(+) regulatory site, similar to an Na(+) coordination motif

242 nded by overlaps between the labels; e.g. if regulatory sites specific to a given cell type are also

243 these parental features and the depletion of regulatory sites such as post-translational modification

244 Putative intergenic regulatory sites, such as the conserved combox sequence

245 e at an artificial, multi-copy array of gene regulatory sites, supporting the use of multi-copy array

246 g) B cells enhanced c-Myc phosphorylation at regulatory sites, sustained higher c-Myc protein levels,

247 mplexes, we have solved the structure of the regulatory site synapse in the Sin resolvase system.

248 rotein interactions of splicing factors with regulatory sites termed silencers or enhancers, RNA-RNA

249 . melanogaster and D. simulans is greater at regulatory sites than expected from levels of intraspeci

250 e show that this cytosolic loop is part of a regulatory site that also includes residues in the G-loo

251 In summary, we have identified a new regulatory site that controls Bax's subcellular distribu

252 ence of FKBP12, and identify a potential new regulatory site that may be exploited in the design of n

253 amino acid Tyr (Y) 155 of the RLC as a novel regulatory site that spatially controls NMII function.

254 on Thr-686, a highly conserved intracellular regulatory site that was required for the PKA-mediated s

255 domain, and the gamma subunits containing 2 regulatory sites that bind the activating and inhibitory

256 Together our results argue that the regulatory sites that control CTP synthase function, but

257 This locus contains multiple regulatory sites that could potentially affect expressio

258 ARVA highlights several novel highly mutated regulatory sites that could potentially be noncoding dri

259 lly dephosphorylating these kinases at a key regulatory site, the hydrophobic motif (Ser-473 in Akt1)

260 strates and products and the proteolytic and regulatory sites; the locations of these sites and the i

261 se risk-susceptibility regions encompass cis-regulatory sites, their transcriptional potential has ne

262 At some regulatory sites, this specificity confers distinct sile

263 for the first time information flux between regulatory sites through a conserved kinase infrastructu

264 ved irritants target the same key allosteric regulatory site to differentially modulate channel activ

265 ar insight into how lncRNAs are recruited to regulatory sites to carry out chromatin-associated funct

266 scription factors then occupy shared genomic regulatory sites to promote chromatin accessibility and

267 pled amino acids in Src kinase that connects regulatory sites to the ATP- and substrate-binding sites

268 We propose that distinct regulatory sites uniquely characteristic of individual A

269 w experimentally that genome editing of some regulatory sites upregulates the expression of GSTM1 and

270 eposits histone H2A.Z at promoters and other regulatory sites via an ATP-driven histone exchange reac

271 sphorylation of CAP1 at the S308/S310 tandem regulatory site was elevated in cancer cells, consistent

272 Although NsrR binding to the class II regulatory sites was NO insensitive in vitro, transcript

273 omoters regardless of the arrangement of cis-regulatory sites we studied.

274 t CaV1.2 channels harboring mutations at key regulatory sites, we show that adrenergic regulation of

275 acquired the coding changes but not the cis-regulatory sites, we show that the coding changes became

276 al recruitment of NF-kappaB to specific gene regulatory sites, we used NF-kappaB p65 in a tandem affi

277 Potential miR-200 (b and c) and miR-217 regulatory sites were identified in mortalin mRNA.

278 analysis implied a second upstream positive regulatory site, which corresponded to a site of weak co

279 the +1166 A/C polymorphism occurred in a cis-regulatory site, which is recognized by a specific micro

280 BAFF-R-expressing cells suggested potential regulatory sites, which allowed the generation of EMSA p

281 In cleaving these regulatory sites, which are characterized by multiple fl

282 ance acetylated residues are proximal to the regulatory sites while the lower abundance phosphorylati

283 regulation, substitutions of individual Chk1 regulatory sites with alanine (A) residues have differen

284 data to optimize thresholds for identifying regulatory sites with each matrix.

285 tion and desaturation of the troponin Ca(2+) regulatory sites with each twitch during calling.

286 We develop a procedure for identifying regulatory sites, with high levels of conservation acros

287 WD40 domain and a previously uncharacterized regulatory site within COP1.

288 y revealed is the existence of an additional regulatory site within GPSM3 directed toward monomeric G

289 at SATB proteins physically associate with a regulatory site within the Eomes promoter.

290 in-capping site, there appears to be another regulatory site within the tropomodulin C-terminal domai

291 teraction of the vitamin D receptor (VDR) at regulatory sites within both the Cyp24a1 and the Trpv6 g

292 Ikaros directly associates with regulatory sites within Cebpa and Hes1 and regulates the

293 ent, the PtREV gene contains three potential regulatory sites within noncoding regions at the gene's

294 asis of allosteric coupling between two Ca2+ regulatory sites within the domain.

295 ng and colleagues identify a large number of regulatory sites within the genomes of non-small cell lu

296 port that Egr-1 binds and activates multiple regulatory sites within the pdx-1 promoter.

297 he Il4, Il5, and Il13 genes as well as other regulatory sites within the Th2 locus.

298 to form nucleosomes--such that, for example, regulatory sites would be 'nucleosome-free'.

299 P-1 dephosphorylates TonEBP/OREBP at a known regulatory site, Y143, both in vivo and in vitro.

300 eruginosa study these were designated as the regulatory site (Zn1) and structural site (Zn2).