ライフサイエンスコーパス: regulatory subunit

1 isting of Nem1 (catalytic subunit) and Spo7 (regulatory subunit).

2 nt on phosphorylation of Ser108 in the beta1 regulatory subunit.

3 t chain or of myosin light chain phosphatase regulatory subunit.

4 affold and catalytic subunits and a variable regulatory subunit.

5 egulatory Associated Protein of TOR (RAPTOR) regulatory subunit.

6 catalytic subunit, a scaffold subunit, and a regulatory subunit.

7 complexes targeted to c-Jun by the PR55alpha regulatory subunit.

8 regulated by the phosphorylation of its B'' regulatory subunit.

9 targeting of the holoenzyme via the CK2beta regulatory subunit.

10 (PP1) subunit in complex with a PPP1R15-type regulatory subunit.

11 are obligate heterodimers with catalytic and regulatory subunits.

12 addition to creating rings, kleisins recruit regulatory subunits.

13 aling pathways when associated with specific regulatory subunits.

14 that is decorated with a variable number of regulatory subunits.

15 eraction is specific to the B' family of the regulatory subunits.

16 ing through increased phosphorylation of PKA regulatory subunits.

17 units with four sulphonylurea receptor (SUR) regulatory subunits.

18 lex composed of four core subunits and seven regulatory subunits.

19 the adaptor protein cyclin-dependent kinase regulatory subunit 1 (Cks1), a cofactor of the SCF(Skp2)

20 latelet-activating factor acetylhydrolase 1b regulatory subunit 1 (PAFAH1B1, also known as LIS1).

21 mphoma 10 (BCL10), phosphoinositide-3 kinase regulatory subunit 1 (PIK3R1), IL21, and Jagunal homolog

22 erentially regulated by LCMT-1, with the PP4 regulatory subunit 1 (PP4R1)-containing PP4 complex bein

23 ion (LoF) variants in protein phosphatase 1, regulatory subunit 12a (PPP1R12A), an important developm

24 we show that the 26 S proteasome non-ATPase regulatory subunit 13 (PSMD13), a newly identified negat

25 The 26S proteasome non-ATPase regulatory subunit 13 mediated degradation specifically

26 generated larvae carrying a mutation in cdk5 regulatory subunit 1a (cdk5r1a), an essential activator

27 Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is a potent protein phos

28 ) also known as phosphoprotein phosphatase-1 regulatory subunit 1B and encoded by the PPP1R1B gene is

29 Protein phosphatase 1 regulatory subunit 1B(+) BLA pyramidal neurons to dopami

30 ith decreased expression of protein kinase A regulatory subunit 1beta (PRKAR1beta), activation of pro

31 We now find that the EVH1 domain of the regulatory subunit 3 of Drosophila PP4, Falafel (Flfl),

32 rns were confirmed for protein phosphatase 1 regulatory subunit 36 (PPP1R36) and ataxin 2 like (ATXN2

33 Moreover, we identified PP1 regulatory subunit 3B (PPP1R3B) as a targeting subunit t

34 ry protein (GCKR), and protein phosphatase 1 regulatory subunit 3b (PPP1R3B) that were strongly assoc

35 ant near the gene for protein phosphatase 1, regulatory subunit 3B (PPP1R3B; rs4841132, beta = -0.116

36 apped region, PPP1R3B (protein phosphatase 1 regulatory subunit 3B), encodes a protein (GL) that regu

37 spn; gene name Ppp1r9b protein phosphatase 1 regulatory subunit 9b) and the clathrin adaptors AP-1 an

38 Mechanistically, TAp73 interacts with the regulatory subunit (alpha) of HIF-1 and recruits mouse d

39 is an endothelial cell (EC)-predominant PP1 regulatory subunit and a member of the myosin phosphatas

40 mouse embryos have reduced levels of PP2A B regulatory subunit and PP4R1 relative to control MEFs, i

41 ed cAMP binding to two tandem domains of the regulatory subunit and release of the catalytic subunit.

42 until the kinase domain associates with its regulatory subunits and overcomes the energetic barrier

43 tivation, the interaction of p47(phox) (NOX2 regulatory subunit) and p52Shc was evaluated by proximit

44 catalytic and one of any of four families of regulatory subunits, and the interaction is specific to

45 Ps anchor protein kinase A (PKA) through PKA regulatory subunits, and we show that AKAP8L can anchor

46 nic kidney cells and rat organs reveals that regulatory subunits are always in large molar excess of

47 We conclude that PKA's regulatory subunits are cAMP-dependent signal transducer

48 so explain why most disease mutations in PKA regulatory subunits are dominant negative.

49 catalytic gamma- and epsilon-subunits, with regulatory subunits arranged in asymmetric trimers assoc

50 e-binding domain of protein kinase A's (PKA) regulatory subunit as a prototype signalling unit, we co

51 dria-localized protein phosphatase 2A (PP2A) regulatory subunit, as a neuron-specific Drp1 activator

52 hao and coworkers find that protein kinase A regulatory subunits assemble liquid droplets to further

53 As p85 regulatory subunits associate with and inhibit all class

54 tes interfaces for efficient binding to CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) and c

55 r mutations in protein phosphatase 2A (PP2A) regulatory subunit B family genes protein phosphatase 2,

56 ify Drosophila protein phosphatase 2A (PP2A) regulatory subunit B' [Wrd (Well Rounded)] as a Liprin-a

57 ubunit B family genes protein phosphatase 2, regulatory Subunit B', beta (PPP2R5B); protein phosphata

58 gamma (PPP2R5C); and protein phosphatase 2, regulatory Subunit B', delta (PPP2R5D).

59 t B', beta (PPP2R5B); protein phosphatase 2, regulatory Subunit B', gamma (PPP2R5C); and protein phos

60 itin proteomics, we identified phosphatase 2 regulatory subunit B'e (PPP2R5e) as a KLHL42 substrate.

61 disrupted its holoenzyme formation with the regulatory subunit B55.

62 Proteomics identified the PP2A regulatory subunit B55alpha as the factor recruiting PP2

63 We show that the PP2A regulatory subunit B55alpha is at the crossroad between

64 hat the Dictyostelium protein phosphatase 2A regulatory subunit B56, encoded by psrA, modulates Dicty

65 A mouse model lacking a key regulatory subunit (B56alpha) of the PP (protein phospha

66 rine/threonine protein phosphatase 2A (PP2A) regulatory subunit, B56beta, due to increased steady-sta

67 luciferase reporter, we identified the PP2A regulatory subunit B56gamma as negative regulator of NF-

68 posed of a catalytic subunit (alpha) and two regulatory subunits (beta and gamma), which act as a met

69 KCa1.1, Kcnma1, Slo1) gene, two families of regulatory subunits, beta and gamma, define BK channels

70 r, we find that the L205R mutation abolishes regulatory-subunit binding, leading to constitutive, cAM

71 mitoBK(Ca) functionally associates with its regulatory subunit BK-beta1 in adult rodent cardiomyocyt

72 Interaction of MAT2A with its MAT2B regulatory subunit causes no change in the intrinsic KIE

73 subunits (CK2alpha and/or CK2alpha') and two regulatory subunits (CK2beta).

74 budding yeast, the holoenzyme comprises two regulatory subunits, Ckb1 and Ckb2, and two catalytic su

75 ruitment of Cdk-cyclin in complex with a Cdk regulatory subunit (Cks) to a hyperphosphorylated loop o

76 The structures show how the catalytic and regulatory subunits communicate with each other to provi

77 ive holoenzymes by binding of different PP2A regulatory subunits compared with wild-type Aalpha, sugg

78 the catalytic subunit is promiscuous and the regulatory subunit confers substrate specificity.

79 n FL-HCC, the DnaJ-PKA chimera remains under regulatory subunit control; however, its overexpression

80 mains by CDK1 in complex with p9/Cks2 (a CDK regulatory subunit) controlled loading of coactivator Cd

81 cific DNA-binding protein Cep3 together with regulatory subunits Ctf13 and Skp1.

82 erodimer composed of the Cdc7 kinase and its regulatory subunit Dbf4.

83 lly during late G1/S phase by binding to its regulatory subunit, Dbf4.

84 isrupt AKAP interaction with the PKA RIIbeta regulatory subunit, decreased inhibition of cAMP product

85 vate PP2A holoenzymes containing a different regulatory subunit, do not dephosphorylate MYBL2, and ar

86 at PKA catalytic subunits remain tethered to regulatory subunits during cAMP elevation.

87 nsists of the catalytic Est2 protein and two regulatory subunits (Est1 and Est3) in association with

88 arepsilon with Frizzled-bound PR61varepsilon regulatory subunit, facilitating the access of PP2A cata

89 a catalytic subunit, factor Xa (fXa), and a regulatory subunit, factor Va (fVa), assembled on a memb

90 For each of the three regulatory subunit families, we engineered A/B charge-sw

91 AHAS requires both catalytic and regulatory subunits for maximal activity and functionali

92 ity, and use NAT-type specific auxiliary and regulatory subunits, for their cellular functions.

93 dification, and/or trafficking in any of the regulatory subunits forming cardiac L-type Ca(2+) channe

94 In mammalian cells, the regulatory subunits GADD34 and CReP target PP1 to dephos

95 a hypomorphic allele of the RPT2 proteasome regulatory subunit gene (rpt2(E301K)) suppressed the ubi

96 ressing, knocking down, or knocking out PP2A regulatory subunits have yielded only limited insights i

97 enzymatic analyses with and without the HYPK regulatory subunit, help to explain some of the phenotyp

98 PKA holoenzyme is a tetramer (R2:C2), with a regulatory subunit homodimer (R2) that binds and inhibit

99 talytic (C) subunits; binding of cAMP to the regulatory subunit homodimer causes activation of the ca

100 In WT S49 cells, PKA-regulatory subunit I (RI) and Bim coimmunoprecipitate up

101 d we show that AKAP8L can anchor PKA through regulatory subunit Ialpha.

102 LRRK2 interacted with PKA regulatory subunit IIbeta (PKARIIbeta).

103 hus, haploinsufficiency for either of PKA-II regulatory subunits improved bone phenotype of mice hapl

104 ignaling, we solved the structure of the PKA regulatory subunit in complex with cAMP and a related an

105 y modified by their functional coupling with regulatory subunits in many tissues.

106 ten unpredicted roles for PI3K catalytic and regulatory subunits in normal cell function and in disea

107 catalytic subunit, which is inhibited by the regulatory subunits in the absence of cAMP.

108 (cAMP-dependent protein kinase type I-alpha regulatory subunit) in 58 SCD patients (P = 7.9 x 10 - 7

109 he expression of PR55alpha (PPP2R2A), a PP2A regulatory subunit, in pancreatic cancer cells compared

110 second messengers rely on more than a dozen regulatory subunits (including B/R2, B'/R5, and B"/R3),

111 , TLC1, the reverse transcriptase, Est2, and regulatory subunits, including Est1.

112 thaliana) SnRK1 catalytic alpha-subunit has regulatory subunit-independent activity, which is consis

113 hils from mice lacking both the p101 and p84 regulatory subunits, indicating that RAS binding to p110

114 a, which encodes for the critical type-I PKA regulatory subunit, induced spontaneous breast tumors ch

115 of the core catalytic subunit PP-1c and the regulatory subunit inhibitor 2 (I-2).

116 m-localized protein phosphatase 2A (PP2A) B' regulatory subunits interact with BRI1 to mediate its de

117 n malignant breast cancer cells, the CK2beta regulatory subunit is downregulated and FOXC2 is found i

118 at the KCNE2 potassium channel transmembrane regulatory subunit is expressed in human and mouse pancr

119 ation of mitochondrial BK (mitoBK(Ca) ) with regulatory subunits is unknown.

120 However, it is now reported that one of the regulatory subunit isoforms (PKA-RIalpha) takes on a fun

121 their activation depends on association with regulatory subunits known as cyclins.

122 at the dinucleotide binds to the cytoplasmic regulatory subunit KtrC and to the KdpD sensor kinase of

123 nits, Lac1 and Lag1, as well as an essential regulatory subunit, Lip1.

124 netic inhibition of ribonucleotide reductase regulatory subunit M2 (RRM2), a rate-limiting enzyme in

125 dentified the RRM2 (ribonucleotide reductase regulatory subunit M2) of RNR as a direct target of DHS.

126 A is downregulated in patients with AF, this regulatory subunit may represent a new target for AF the

127 nase 8 (CDK8), is controlled by Cyclin C and regulatory subunit MED12, with its deregulation contribu

128 cation of B56delta, which we identify as the regulatory subunit mediating PP2A-dependent Bcl-2 dephos

129 of the mitochondrial calcium uniporter (MCU) regulatory subunit MICU1 leads to a notable increase in

130 osphorylates the protein phosphatase 1 (PP1) regulatory subunit myosin phosphatase targeting subunit

131 t chain phosphatase (MLCP), which contains a regulatory subunit MYPT1 bound to the phosphatase cataly

132 estigated the physiological role of the MLCP regulatory subunit MYPT1 in bladder smooth muscle contai

133 estigated the physiological role of the MLCP regulatory subunit MYPT1 in ileal smooth muscle in adult

134 it (MYPT) family member, in addition to MLCP regulatory subunit MYPT1.

135 MLCP with its regulatory subunit MYPT2 bound tightly to myofilaments w

136 tor of kappaB (IkappaB) kinase (IKK) complex regulatory subunit NEMO [nuclear factor kappaB (NF-kappa

137 , USP18 targeted the IKK complex through the regulatory subunit NEMO of IKK, and specifically inhibit

138 bunits, IKKalpha and IKKbeta, as well as the regulatory subunit, NEMO-mediates activation of the nucl

139 al structures and biophysical studies of the regulatory subunit, NeqB, the apo-NeqAB, and NeqAB in co

140 Stromalin and the cohesin regulatory subunit Nipped-B are required for neuroblast

141 ASXL1 is the obligate regulatory subunit of a deubiquitinase complex whose cat

142 The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates t

143 k2 as query mutants, the latter encoding the regulatory subunit of AMPK.

144 F2alpha phosphorylation [CReP]) encoding the regulatory subunit of an eIF2alpha-specific phosphatase

145 e sulfonylurea receptor 2B (SUR2B) forms the regulatory subunit of ATP-sensitive potassium (KATP) cha

146 processes, we mutagenized Mcd1p, the kleisin regulatory subunit of budding yeast cohesin.

147 Here, we reveal that the type I regulatory subunit of cAMP-dependent protein kinase (PKA

148 n of cyclin E1 (CCNE1), which functions as a regulatory subunit of CDK2.

149 ations in PIK3R1, which encodes the p85alpha regulatory subunit of class IA PI3Ks, lead to immunodefi

150 and chronic depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin

151 Mice lacking the RIIbeta regulatory subunit of cyclic AMP-dependent protein kinas

152 Upon exit from prophase I, Dbf4, the regulatory subunit of DDK, directly associates with and

153 show here that the mRNA of CReP/Ppp1r15b, a regulatory subunit of eukaryotic translation initiation

154 ssion of the cystine transporter xCT and the regulatory subunit of glutamate-cysteine ligase (GCLM) i

155 pregulated HIF-1 activity by stabilizing the regulatory subunit of HIF-1 (HIF-1alpha) in a murine bre

156 a inducible factor 1 alpha (HIF-1alpha), the regulatory subunit of HIF-1, a master transcriptional re

157 u-mediated ubiquitination of HIF-1alpha, the regulatory subunit of HIF-1, and consequently promotes m

158 of residues of the catalytic domain and the regulatory subunit of human PI3Kalpha in lipid and prote

159 ntrolled by IKKgamma (also called NEMO), the regulatory subunit of IKK complex.

160 eration and found that a mutation in the p80 regulatory subunit of katanin, encoded by the PF15 gene

161 myosin phosphatase-targeting subunit 1, the regulatory subunit of myosin phosphatase that is inhibit

162 otion that PII proteins act as a dissociable regulatory subunit of NadE(Gln), thereby enabling the co

163 Mutation or loss of the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3

164 The canonical action of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase (PI3

165 PIK3R2 encodes the p85beta regulatory subunit of phosphatidylinositol 3-kinase and

166 osis through the recruitment of the p85alpha regulatory subunit of phosphatidylinositol-3-kinase (PI3

167 heterozygous mutations in PIK3R1 encoding a regulatory subunit of phosphoinositide-3-kinase (PI3K).

168 raction with Crk family proteins and the p85 regulatory subunit of PI3-Kinase, respectively.

169 sphatase type II (SHP2) to the Pi3k21B (p60) regulatory subunit of PI3K (p50/p85 human ortholog) but

170 mutations in the gene encoding the p85alpha regulatory subunit of PI3K (PIK3R1) have been identified

171 We have demonstrated that the p85alpha regulatory subunit of PI3K modulates the unfolded protei

172 iated interaction of PRR11 with the p85alpha regulatory subunit of PI3K suppresses p85 homodimerizati

173 We identified a role for the p85alpha regulatory subunit of PI3K to modulate the UPR by promot

174 PIK3R1 (p85alpha regulatory subunit of PI3K) is frequently mutated across

175 K3R1, the gene that encodes for the p85alpha regulatory subunit of PI3K, have been recently identifie

176 nsense mutation in PIK3R1, which encodes the regulatory subunit of PI3K, in a metastatic RCC (mRCC),

177 ing catalytic p110alpha subunit and p85alpha regulatory subunit of PI3K, leading to activation of AKT

178 of Pik3r1 expression, which encodes the p85 regulatory subunit of PI3K.

179 -cyclic phosphodiesterase 4D (PDE4D) and the regulatory subunit of PKA (PRKAR1alpha) content culminat

180 MP-binding domains (CBD-A and -B) within the regulatory subunit of PKA (R), unleashing the activity o

181 y high-affinity association of cAMP with the regulatory subunit of PKA and signal termination is achi

182 Leu206 directly interacts with the regulatory subunit of PKA, PRKAR1A.

183 chieved through direct interactions with the regulatory subunit of PKA, thereby facilitating cAMP dis

184 e length: Prkar1a, which encodes the R1alpha regulatory subunit of PKA.

185 t miR-297c-5p targets cyclin T2 (CCNT2), the regulatory subunit of positive transcription elongation

186 Multisite phosphorylation of the I-2 regulatory subunit of PP-1I leads to activation or inact

187 CKA is a regulatory subunit of PP2A, a component of the STRIPAK c

188 opening, and resulted in the truncation of a regulatory subunit of PP2A, B56alpha.

189 PRKAR1A deficiency; PRKAR1A codes for type-I regulatory subunit of protein kinase A (PKA).

190 ng of two protein-ligand systems: cAMP-bound regulatory subunit of Protein Kinase A (RIalpha) and IBM

191 f eIF2alpha by increased levels of GADD34, a regulatory subunit of protein phosphatase 1 (PP1).

192 GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that

193 cule that safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

194 revealed that tumor suppressor PPP2R2A, a B regulatory subunit of protein phosphatase 2 (PP2A), dete

195 kdown of PPP2R1A, a gene encoding a constant regulatory subunit of protein phosphatase 2, significant

196 rovide data that demonstrate that B55beta, a regulatory subunit of protein phosphatase 2A, represents

197 mage in the brain of mice lacking the Bbeta2 regulatory subunit of protein phosphatase 2A, which we h

198 Gankyrin is a regulatory subunit of the 26kD proteasome complex.

199 PPP3R1 is the regulatory subunit of the calcineurin complex.

200 Cyclin E1 (CcnE1) is the regulatory subunit of the cyclin-dependent kinase 2 (Cdk

201 ctor kinase Rad53 and the BRCT domain of the regulatory subunit of the Dbf4-dependent kinase that is

202 characterized the function of BAF250a, a key regulatory subunit of the ES cell ATP-dependent Brahma-a

203 The cyclin D1 gene product encodes the regulatory subunit of the holoenzyme that phosphorylates

204 B (NF-kappaB) essential modulator (NEMO; the regulatory subunit of the IkappaB kinase [IKK] complex).

205 p47 also binds to Kenny (IKKgamma/NEMO), the regulatory subunit of the inhibitor of nuclear factor (N

206 eleterious mutations in KATNB1, encoding the regulatory subunit of the microtubule-severing enzyme Ka

207 consistently elevated expression of MICU2, a regulatory subunit of the mitochondrial calcium uniporte

208 o identify how the genetic deletion of a key regulatory subunit of the mitochondrial permeability tra

209 KBTBD2 targeted p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K

210 Jak3 interacted with and activated p85, the regulatory subunit of the PI3K, through tyrosine phospho

211 dentified a mosaic mutation (Gly373Arg) in a regulatory subunit of the PI3K-AKT-mTOR pathway, PIK3R2,

212 One of the target genes was Ppp2r2d, a regulatory subunit of the PP2A phosphatase family.

213 to increased phosphorylation of the E1alpha regulatory subunit of the pyruvate dehydrogenase complex

214 counts, along with ANKRD52, the phosphatase regulatory subunit of the recently identified AGO phosph

215 T cells promoted interaction of the p85alpha regulatory subunit of the signaling kinase PI(3)K and in

216 t that conditional knockout of Cdh1, the key regulatory subunit of the ubiquitin ligase Cdh1-anaphase

217 The main target of cAMP is PKA, the main regulatory subunit of which (PRKAR1A) presents mutations

218 Importantly, the beta and gamma regulatory subunits of AMPK are not required to control

219 By systematically testing the regulatory subunits of Drosophila PP2A, we find that the

220 is also able to degrade the PPP2R5 family of regulatory subunits of key cellular phosphatase PP2A (PP

221 on channels, to have both functions or to be regulatory subunits of other channels.

222 Thus, regulatory subunits of phosphatases are drug targets, a

223 Here we report that the regulatory subunits of phosphoinositide-3 kinase (PI3K)-

224 SL and Plin1 and the levels of catalytic and regulatory subunits of PKA were increased by glucocortic

225 MEI-S332 can bind directly to both of the B' regulatory subunits of PP2A, Wdb and Wrd, in yeast two-h

226 Regulatory subunits of protein kinase A (PKA) inhibit it

227 radation of all members of the B56 family of regulatory subunits of the key cellular phosphatase PP2A

228 We propose that MrpL35 and Mrp7 are regulatory subunits of the mitoribosome acting to coordi

229 both Tim44 and Pam17 have been implicated as regulatory subunits of the motor, this positioning is co

230 ure motif F-X-Y-D and act as tissue-specific regulatory subunits of the Na,K-ATPase.

231 The auxiliary and regulatory subunits of the NatA complex are NAA15 and Hu

232 recruitment of PP1 (the Dis2 isoform) to the regulatory subunits of the PP2A-B55 and PP2A-B56 (B55 al

233 We found that the regulatory subunits of these AHAS complexes form a core

234 Increased p25, a proteolytic fragment of the regulatory subunit p35, is known to induce aberrant acti

235 ic subunit (p125), pol delta comprises three regulatory subunits (p50, p68, and p12).

236 plex with the NGF receptor TrkA and the PI3K regulatory subunit p85, with the degree of TrkA:p85 asso

237 Although the PI3-kinase regulatory subunits p85alpha and p85beta are dispensable

238 Expression of the regulatory subunit p85beta of PI3K induces oncogenic tra

239 Interestingly, PfCDPK1 phosphorylates PfPKA regulatory subunit (PfPKA-R) and regulates PfPKA activit

240 etic ablation of the insulin receptor or the regulatory subunits phosphatidylinositol 3-kinase (PI3K)

241 SY protein directly interacted with the PI3K regulatory subunit PI3K-P85alpha, which increased AKT an

242 Palmitoylated EGFR interacted with the PI3K regulatory subunit PIK3R1 (p85) and increased the recrui

243 cular disulfide formation between PKA type I regulatory subunits (PKA-RI) has been described to enhan

244 ytosolic cAMP receptor, the protein kinase A regulatory subunit (PKAR).

245 cAMP binding to the regulatory subunits (PKAR) relieves their inhibition of

246 co-immunoprecipitation of SERCA2, cav3, PKA regulatory subunit (PKARII), PP2A, and AKAP18 with PDE3A

247 veals an unexpected arrangement in which the regulatory subunits (Pol31 and Pol32) lie next to the ex

248 of the catalytic subunit Pol3 along with two regulatory subunits, Pol31 and Pol32.

249 of a catalytic subunit POLD1/p125 and three regulatory subunits POLD2/p50, POLD3/p66 and POLD4/p12.

250 nt stages of plant development, and the PP2A regulatory subunit PP2A-B'gamma is required for negative

251 PP2A associated with the Rts1 regulatory subunit (PP2A(Rts1)) is embedded in a feedbac

252 PP2A associated with the Rts1 regulatory subunit (PP2A(Rts1)) is required for cell siz

253 s and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP.

254 Proteomics identified the PP1-regulatory subunit PPP1R3A as a novel RyR2-binding partn

255 Proteomic analysis uncovered a novel PP1-regulatory subunit (PPP1R3A [PP1 regulatory subunit type

256 omplex: the PPP1CA catalytic subunit and the regulatory subunits PPP1R9B, PPP1R12A and PPP1R18.

257 motifs bind to a conserved pocket in the PP4 regulatory subunit PPP4R3.

258 ), including the catalytic subunit PPP6C and regulatory subunits PPP6R1 and PPP6R3.

259 Mutations of the regulatory subunit (PRKAR1A) of the cyclic adenosine mon

260 p of PCNA in an open configuration while the regulatory subunits project laterally.

261 receptor for protein kinase 1 (RACK1) as the regulatory subunit, protein phosphatase 2A (PP2A) dephos

262 the central receptor for cAMP is the single regulatory subunit (R) of protein kinase A (PKA).

263 KAR1A tumor suppressor gene that encodes the regulatory subunit R1alpha of the cAMP-dependent protein

264 nalysis suggests that the nSH2 domain in the regulatory subunit regulates activation, catalysis and a

265 NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently o

266 n experiments showed that a group of PP2A B' regulatory subunits, represented by B'eta, negatively re

267 In this work, we examined Spo7, a regulatory subunit required for Nem1 catalytic function,

268 ry subunits to Abeta, and knockdown of these regulatory subunits restored colony-forming ability.

269 selective high-affinity AKAP for type I PKA regulatory subunits (RI).

270 cleotide phosphodiesterase (PDE8A) and a PKA regulatory subunit (RIalpha isoform) in mammalian cAMP s

271 We recently reported that type I PKA regulatory subunits (RIalpha) interact with phosphatidyl

272 We also show that the catalytic and regulatory subunits rotate relative to each other and th

273 teasomal ubiquitin receptors, 26S proteasome regulatory subunit RPN10 (RPN10) and Rpn13 homolog (RPN1

274 easome, which is critically dependent on the regulatory subunit Rpn6.

275 from mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiolo

276 instead, depends on PP1 phosphatase and its regulatory subunit Sds22.

277 scription factor TCP8-like (TCP8) and a PP2A regulatory subunit TAP46-like (TAP46) were indeed phosph

278 y the lack of knowledge of how their diverse regulatory subunits target highly conserved catalytic su

279 trols mitosis is associated with a conserved regulatory subunit that is called B55 in vertebrates and

280 d directly phosphorylates PP4R3beta, the PP4 regulatory subunit that recognizes 53BP1.

281 of the lipid kinase subunit VPS34 and three regulatory subunits that altogether function as a protot

282 in diabetes (downregulation of an inhibitory regulatory subunit) that leads to deficits of circulatin

283 to the paradigm of distinct PP1-targeting or regulatory subunits, the unique N terminus of yeast eIF2

284 , during which the two cAMPs unbind from the regulatory subunit to allow association of the catalytic

285 KCNE) subunit 4, acts as a dominant negative regulatory subunit to both enhance inactivation and indu

286 irect binding of the EVH1 domain of the Psy2 regulatory subunit to the polyproline motif of Mth1.

287 revealed increased binding of specific PP2A regulatory subunits to Abeta, and knockdown of these reg

288 nit, allowing TIPRL, but not the overlapping regulatory subunits, to tolerate disease-associated PP2A

289 rising a lipid kinase, PI4KIIIalpha, and two regulatory subunits, TTC7 and FAM126.

290 a novel PP1-regulatory subunit (PPP1R3A [PP1 regulatory subunit type 3A]) in the RyR2 macromolecular

291 ression of beta-adrenergic pathway genes PKA regulatory subunit type I, PKA regulatory subunit type I

292 way genes PKA regulatory subunit type I, PKA regulatory subunit type II, and Ca(2+)/calmodulin-depend

293 ncoding the p85alpha, p55alpha, and p50alpha regulatory subunits (type 2 APDS).

294 the hypothesis that the PRKAR2A and PRKAR2B regulatory subunits were in part responsible for the bon

295 oth PKA catalytic subunit mutants by the PKA regulatory subunit, whereas cells from patients with ger

296 P2R1A increased its binding ability with B56 regulatory subunits, whereas PPP2R1A-mutations lost the

297 cible expression of pairs of scaffolding and regulatory subunits with complementary charge-reversal s

298 cificity through the interaction of distinct regulatory subunits with conserved catalytic subunits in

299 acidic loop of the PPP2R5D-encoded B56delta regulatory subunit, with the same E198K mutation present

300 PPP1R3A is a novel PP1-regulatory subunit within the RyR2 channel complex.