ライフサイエンスコーパス: reinitiation

1 -1.20) during follow-up were associated with reinitiation.

2 lease and thereby repressing transcriptional reinitiation.

3 n and also contributes to metastatic lesions reinitiation.

4 ntify miR-335 as a robust inhibitor of tumor reinitiation.

5 eEF3 action promotes ribosome recycling, not reinitiation.

6 ggesting CDK8 involvement in transcriptional reinitiation.

7 es (PICs), but permits few rounds of RNAP II reinitiation.

8 and duration of expression through frequent reinitiation.

9 by a mechanism involving delayed translation reinitiation.

10 t matter of upstream E6*I ORF by translation reinitiation.

11 formation of a pre-RC is not sufficient for reinitiation.

12 evels of active DnaA are reduced, preventing reinitiation.

13 rty of the synthase is chain termination and reinitiation.

14 e Scaffold complex involved in transcription reinitiation.

15 verlapping mechanisms efficiently preventing reinitiation.

16 cation, oriC, from methylation and premature reinitiation.

17 TFIIF complex is competent for transcription reinitiation.

18 embly of a follow-on PIC at the promoter for reinitiation.

19 n complex activates replication and prevents reinitiation.

20 re of TBP interactions during initiation and reinitiation.

21 A and appeared to involve either shunting or reinitiation.

22 damage-induced activation through efficient reinitiation.

23 mulation of multiple cycles of transcription reinitiation.

24 mplex and leads to a defect in transcription reinitiation.

25 pendent loss of protein factors required for reinitiation.

26 initiation, without affecting transcription reinitiation.

27 ation for subsequent rounds of transcription reinitiation.

28 pressor specifically targets transcriptional reinitiation.

29 the occurrence of leaky scanning along with reinitiation.

30 ulate transcription preinitiation as well as reinitiation.

31 nthesis is resumed, resulting in cell growth reinitiation.

32 y of productive transcription initiation and reinitiation.

33 roughout the cell cycle but does not promote reinitiation.

34 nteracts directly with proteins required for reinitiation.

35 ing scanning ribosomes, and not by affecting reinitiation.

36 effect on the efficiency of termination and reinitiation.

37 n high rates of transcription initiation and reinitiation.

38 ome but not all nonviral sequences inhibited reinitiation.

39 intergenic region also influenced polymerase reinitiation.

40 considerably faster than product release or reinitiation.

41 regulate replication by preventing premature reinitiation.

42 ciated with high persistence after treatment reinitiation.

43 ith >/=1 day of statin supply 182 days after reinitiation.

44 bsequent activator-independent transcription reinitiation.

45 ption elongation and maintains transcription reinitiation.

46 e engagement was associated with greater ART reinitiation.

47 ation complexes and the activity persists at reinitiation.

48 sid protein VP2 is expressed via termination/reinitiation.

49 contains three sequence motifs essential for reinitiation.

50 otein, and resets the polymerase complex for reinitiation.

51 ncluding the facilitation of transcriptional reinitiation.

52 tion, which enhances the rate of translation reinitiation.

53 On reinitiation, 27.1% changed statin type, 6.9% up-titrate

54 In the 182 days after reinitiation, 45.8% had high persistence.

55 ion of eIF2 during stress delays translation reinitiation, allowing scanning ribosomes to bypass uORF

56 This delayed reinitiation allows for ribosomes to scan through the in

57 nuation, reinitiation, and persistence after reinitiation among Medicare beneficiaries after hospital

58 mechanisms for escaping the first-AUG rule--reinitiation and context-dependent leaky scanning--enabl

59 proteins not only by polyprotein processing, reinitiation and frameshifting but also by using multipl

60 persistently open state to facilitate rapid reinitiation and perhaps also to bypass TFIIH-dependent

61 ciated factors have been shown to facilitate reinitiation and regulate transcription in some species.

62 Then, we observed the reinitiation and reorientation of protein synthesis, acc

63 role for ABCE1 in translation recycling and reinitiation and revisits the interpretation of Simonett

64 uch as scanning, start codon recognition, or reinitiation and suggest that poor translation initiatio

65 ning the patterns of statin discontinuation, reinitiation, and persistence after reinitiation among M

66 chanisms - context-dependent leaky scanning, reinitiation, and possibly direct internal initiation -

67 es in unconventional translation initiation, reinitiation, and recycling.

68 in AAV DNA replication: terminal resolution, reinitiation, and strand displacement.

69 combination of leaky ribosomal scanning and reinitiation, and that the sequences surrounding the PB1

70 yploid macronucleus, mechanisms that prevent reinitiation appear intact.

71 hat properties of uORFs that permit ribosome reinitiation are critical for directing gene-specific tr

72 Signals for termination-reinitiation are found within a 32-nucleotide stretch of

73 The consequences of reinitiation are unknown.

74 The gradual decrease in reinitiation as an upORF is lengthened, confirmed here u

75 ve initiation, and promoter clearance and/or reinitiation, as measured by multiple rounds of transcri

76 G codon, suggesting downstream translational reinitiation at a putative TTG start.

77 ontaining scaffold facilitates transcription reinitiation at active promoters.

78 tion delays ribosome capacitation and favors reinitiation at ATF4 over the inhibitory uORF2.

79 ement that facilitates ribosome scanning and reinitiation at downstream coding regions in the ATF4 mR

80 sed reinitiation at uORFs 3 or 4 and reduced reinitiation at Gcn4p.

81 de novo initiation at upstream genes versus reinitiation at overlapping gene pairs.

82 on control switch that specifically prevents reinitiation at replicated origins.

83 etween R-loops and Sgs1-mediated replication reinitiation at stalled forks and identifies R-loops uni

84 ha-P via an uORF that allows for translation reinitiation at the CReP coding region independent of st

85 ll elongating ribosomes and prevent ribosome reinitiation at the downstream CHOP coding sequence.

86 RF in GADD34 acts as a barrier that prevents reinitiation at the GADD34 coding region.

87 of F protein by interfering with termination/reinitiation at the M-F gene junction, thus promoting th

88 Although reinitiation at the original start site is independent o

89 nd removed from the nascent plus-strand DNA, reinitiation at the resulting plus-strand primer terminu

90 Adding purified eIF2 increased reinitiation at uORFs 3 or 4 and reduced reinitiation at

91 Target of rapamycin (TOR) promotes reinitiation at upstream ORFs (uORFs) in genes that play

92 ased replication blockage and thus increased reinitiation away from oriC, also exacerbates DnaB-induc

93 on, possibly at the level of transcriptional reinitiation/bursting.

94 resulted in longer wait times for treatment reinitiation, but no adverse visual outcomes were identi

95 ion abolishes ROP2 regulation of translation reinitiation, but not its effects on cytoskeleton or int

96 of isomerization, promoter clearance, and/or reinitiation by phosphorylated KID to enhance target gen

97 ribosomal tethering of mRNA by TURBS allows reinitiation by post-termination 80S ribosomes and dimin

98 on eukaryotic initiation factor 3 (eIF3) of reinitiation by recycled 40S subunits, which can be medi

99 itro, a subset of Pol II factors facilitates reinitiation by remaining very stably bound to the promo

100 scription is achieved through many rounds of reinitiation by RNA polymerase (pol) III on stable DNA-b

101 e for chain extension of the zwitterions and reinitiation by the N-heterocyclic carbenes liberated up

102 esulting gene loops facilitate transcription reinitiation by the same molecule of RNAP II in a manner

103 To determine the advantages conferred on reinitiation by TURBS, we reconstituted this process in

104 Interestingly, we were able to show that reinitiation can occur at AUG codons downstream of the c

105 hat the uORF length-dependence of changes in reinitiation competence is affected by peptide elongatio

106 ore linked to the kinetics of acquisition of reinitiation-competence by post-termination ribosomes in

107 complex (ITC), elongation complex (EC), and reinitiation complex (EC+ITC).

108 as a scaffold for formation of a functional reinitiation complex.

109 The inhibition of F gene reinitiation correlated with foreign sequences having a

110 Reinitiation, defined by a statin fill, was identified i

111 ed mRNAs are sorted and processed for either reinitiation, degradation, or packaging into stable nonp

112 tion-initiation, elongation, and termination/reinitiation-determine protein synthesis rates even at l

113 to be translated is progressively truncated, reinitiation downstream of an uORF of 105nt is found to

114 int signaling and triggering DNA replication reinitiation during the S-phase checkpoint recovery.

115 a result of a novel translation termination/reinitiation event between the nonstructural-protein and

116 2 undergoes multiple consecutive replication reinitiation events at the genomic termini.

117 posttermination ribosomes suggests that some reinitiation events could involve 80S ribosomes rather t

118 placement replication strategy, the multiple reinitiation events from one parental template yield hig

119 , the CDK8 submodule strongly represses even reinitiation events, suggesting a means to fine tune tra

120 o help regulate transcription initiation and reinitiation events.

121 igins, some of which are capable of multiple reinitiation events.

122 ropose a new model in which TAFs function as reinitiation factors, accounting for the differential re

123 p), has been proposed to depend on ribosomal reinitiation following termination of the upstream ORF,

124 ucose sensitivity is a function of ribosomal reinitiation following translation of an upstream open r

125 This indicates that eIF2 affects the site of reinitiation following translation of GCN4 uORF1 in vitr

126 The probability of wean from PN without reinitiation for at least 1 year, as determined by logis

127 lude leaky scanning, shows barely detectable reinitiation from an AUG codon positioned 4 nt upstream

128 from the terminator codon and no detectable reinitiation from an AUG codon positioned farther upstre

129 mark of activated transcription is efficient reinitiation from promoter-bound scaffold complexes that

130 ot essential for but regulates transcription reinitiation in a length-dependent but sequence-independ

131 ly need eIF4G and eIF4A: There was efficient reinitiation in a standard reticulocyte lysate, when ini

132 ion would be largely driven by eIF4F, but no reinitiation in an eIF4G-depleted lysate.

133 ts, suggesting involvement of uORF usage and reinitiation in clock regulation.

134 This genome-wide analysis suggests that reinitiation in G2/M phase primarily occurs at a subset

135 The efficiency of reinitiation in mammalian translation systems depends in

136 associated with antiretroviral therapy (ART) reinitiation in Medicaid enrollees.

137 ERK was not sufficient to promote cell cycle reinitiation in MMC-treated KSR1(-/-) cells.

138 ed visualization of packaging initiation and reinitiation in real time and quantification of motor as

139 xamine the underlying mechanism, we examined reinitiation in vitro using a series of mRNAs that diffe

140 TERMINI repeat unit enables the quantitative reinitiation, in the presence or absence of a catalyst,

141 Features required for this reinitiation include an upstream translation start and a

142 The efficiency of this event, termed here as reinitiation, increases with supplement of a sigma facto

143 d elongation assays using heparin to prevent reinitiation indicated that LEF-5 was active only in the

144 d not influence M gene termination or F gene reinitiation, indicating that M-F intergenic length per

145 Here we describe the isolation of a reinitiation intermediate that includes transcription fa

146 al mechanisms involving either translational reinitiation, internal ribosomal entry, or leaky ribosom

147 to be in the range of 60 to 75 nt/s, with a reinitiation interval of approximately 1.2 s.

148 Another aspect of reinitiation investigated here is whether post-terminati

149 ts suggest that the mechanism of translation reinitiation involving uORFs is conserved from yeast to

150 Transcriptional reinitiation is a distinct phase of the RNA polymerase I

151 Reinitiation is a strategy used by viruses to express se

152 Prior work has shown that reinitiation is deficient in nuclear extracts from Chine

153 Studies in yeast have shown that the rate of reinitiation is increased by facilitated recycling, a pr

154 stress suggest that modulating recycling and reinitiation is involved in responding to environmental

155 These data indicate that cell cycle reinitiation is not actively signaled in the absence of

156 detailed analyses revealed that the site of reinitiation is not fixed to a single codon and does not

157 show that pulsatile mRNA production, through reinitiation, is crucial for the dependence of noise on

158 dentified two causal mechanisms, translation reinitiation leading to N-terminally truncated target pr

159 in how ribosomes bypass the uORFs, including reinitiation, leaky scanning, and internal initiation of

160 help to define the circumstances under which reinitiation may be expected to occur in the growing num

161 uORFs facilitates ORF35 expression, while a reinitiation mechanism after translation of the uORFs en

162 s of the process, disrupts the gene-specific reinitiation mechanism for translation of GCN4 mRNA and

163 gulates PB1-N40 expression, most likely by a reinitiation mechanism that permits skipping of AUG4.

164 A coupled termination-reinitiation mechanism that requires host or eukaryotic

165 translated by an unconventional termination/reinitiation mechanism.

166 ) expression is regulated by a translational reinitiation mechanism.

167 fect of slowing elongation is limited to the reinitiation mode.

168 ycling RNAP diffuses on the DNA template for reinitiation most of the time.

169 iate structure, initiation, termination, and reinitiation must be accurate and efficient.

170 Our data show that recycling and reinitiation must be distinct processes in Saccharomyces

171 pen reading frames (ORFs) on cellular mRNAs, reinitiation occurs efficiently on subgenomic bicistroni

172 Reinitiation occurs in either of two reading frames in t

173 rnation) states with additional recovery for reinitiation of a new active state by observing the meta

174 Reinitiation of active therapy led to viral decay and re

175 9.3%) patients maintained sinus rhythm after reinitiation of antiarrhythmic drugs, and an additional

176 patients who had a relapse had a response to reinitiation of antibiotic therapy.

177 y tract infection, without a higher rate for reinitiation of antibiotics after discontinuation.

178 l failure, a composite of rehospitalization, reinitiation of antibiotics, or all-cause mortality with

179 ent developed new efavirenz resistance after reinitiation of antiretroviral therapy.

180 sponded to discontinuation of tacrolimus and reinitiation of antiviral therapy.

181 spiked but rapidly returned to baseline with reinitiation of ART.

182 oirs nor immunologic abnormalities following reinitiation of ART.

183 ,640 HIV-1 copies/ml 5 days later, prompting reinitiation of ART.

184 Recurrent ONJ followed reinitiation of bisphosphonates in six of 12 patients.

185 delayed maturation of palisade, and ectopic reinitiation of blade primordia along the midrib.

186 In addition, our findings suggest that reinitiation of cambial activity and transdifferentiatio

187 ion of protein synthesis, accompanied by the reinitiation of cell division and de novo cell wall synt

188 and polarized mammary acini initially led to reinitiation of cell proliferation, increased survival o

189 r 402 phosphorylation also ensures efficient reinitiation of cell tip growth and cell division during

190 erious condition, as it implies the need for reinitiation of dialysis with associated morbidity and m

191 ring each cell cycle in these cells to allow reinitiation of DNA replication in the next cell cycle.

192 in A-Cdk2-dependent process, suggesting that reinitiation of DNA replication is prevented by removal

193 l, an early event in recombination-dependent reinitiation of DNA replication.

194 8 and Cdt1, contributes to the prevention of reinitiation of DNA replication.

195 Cdc2 kinase activity is required to prevent reinitiation of DNA replication.

196 microM, a range similar to that reported for reinitiation of DNA synthesis and activation of the seru

197 et-derived growth factor (PDGF), promote the reinitiation of DNA synthesis and cell growth through mu

198 e promotion of translesion synthesis and the reinitiation of DNA synthesis by homologous recombinatio

199 phase and failure of cytokinesis; subsequent reinitiation of DNA synthesis results in polyploidy.

200 , as indicated by derepression of cyclin D1, reinitiation of DNA synthesis, and acquisition of basal

201 f EGFR tyrosine kinase activity, blocked the reinitiation of DNA synthesis, demonstrating that growth

202 utrient replenishment and growth factors for reinitiation of DNA synthesis, whereas HCT116 cells requ

203 posure to proximal tubular cells resulted in reinitiation of DNA synthesis, whereas no such effect wa

204 dant with regulation of Cdc18 for preventing reinitiation of DNA synthesis.

205 oid, presumably as a result of inappropriate reinitiation of DNA synthesis.

206 whereas lymphocyte turnover decreased after reinitiation of drug treatment.

207 ppeared at points of cell contact during the reinitiation of epithelial continuity.

208 Reinitiation of epoetin therapy among individuals could

209 To maintain genomic stability, reinitiation of eukaryotic DNA replication within a sing

210 a mechanism for loss of tissue polarity and reinitiation of growth associated with MMP9 activity.

211 cell-mediated allograft rejection requiring reinitiation of hemodialysis.

212 ormalization of RA levels is associated with reinitiation of hf development.

213 e showed that these motifs are essential for reinitiation of huNV VP2 translation.

214 even patients were treated with increased or reinitiation of immunosuppression therapy; all returned

215 This GTP hydrolysis was required for reinitiation of import of a nuclear localization sequenc

216 terioration in glycemic control, followed by reinitiation of insulin therapy.

217 In conclusion, these results suggest that reinitiation of kidney development from a population of

218 ng-term respiratory outcomes associated with reinitiation of mechanical ventilation prevents assessme

219 hronic respiratory morbidity associated with reinitiation of mechanical ventilation.

220 ication was sufficient and necessary for the reinitiation of meiosis.

221 th interphase chromosomes is involved in the reinitiation of mitotic chromosome condensation in conju

222 ing acute phase, systolic BP at 4 hours, and reinitiation of OAC for long-term treatment.

223 to PhaC was approximately 60, which required reinitiation of polymer formation on PhaC.

224 Moreover, temporal control over reinitiation of polymer growth was achieved during on/of

225 ferentiation but did inhibit Ca(2+)-mediated reinitiation of proliferation and reversion in different

226 When the shock strength was low, immediate reinitiation of reentry and ventricular fibrillation mig

227 ression of RNF4, AURKA, or PLK1 returned the reinitiation of replication in Atr-deleted cells to near

228 CtrA approximately P then blocks the reinitiation of replication while regulating the transcr

229 ant deposition is a crucial event during the reinitiation of replicative DNA synthesis.

230 e expression of the nuclear isoform requires reinitiation of ribosomes at the M27 AUG after terminati

231 es downstream translation due to inefficient reinitiation of ribosomes that translate uORF, the hairp

232 We conclude that CDK inhibits reinitiation of S phase during G(2), and if G(2)/M CDK i

233 ation of the genome once in each cell cycle, reinitiation of S phase is prevented in G(2) and origins

234 The reinitiation of smallpox vaccination has renewed interes

235 ror agent has heightened the interest in the reinitiation of smallpox vaccination.

236 cision repair, homologous recombination, and reinitiation of stalled replication forks [3, 4].

237 s role in lagging-strand DNA replication and reinitiation of stalled replication forks, we propose th

238 e further demonstrate a role for KSR1 in the reinitiation of the cell cycle and proliferation followi

239 tary global inhibitory mechanism followed by reinitiation of the continuing actions; or (2) a balance

240 The altered morphology is not a result of reinitiation of the myonuclei cell cycle nor is it due t

241 p dual-deallylation reaction thus allows the reinitiation of the polymerase reaction and increases th

242 Reinitiation of therapy at the prior effective dose led

243 these populations again contracted following reinitiation of therapy.

244 o pre-HAART-termination levels 8 weeks after reinitiation of therapy.

245 To obtain insights into the mechanism of reinitiation of this proliferative response in different

246 Reinitiation of tocilizumab therapy led to good uveitis

247 ns to affect both termination and initiation/reinitiation of transcription by human RNA polymerase II

248 APII from the terminator to the promoter for reinitiation of transcription through TFIIB-Ssu72 mediat

249 tively affects multiple-round transcription (reinitiation of transcription) and termination.

250 e case for Set2 in yeast, MET-1 prevents the reinitiation of transcription.

251 Curiously, the N184X mutation triggers the reinitiation of translation at a third start codon in SP

252 sharply under osmotic stress, the subsequent reinitiation of translation is retarded, and "processing

253 bundant N-terminus truncated proteins due to reinitiation of translation were detected in E60X-CFTR.

254 ranslation, including premature cessation or reinitiation of translation, and read-through, resulting

255 ent during interruption of therapy and after reinitiation of treatment.

256 duplex DNA followed by rapid reannealing and reinitiation of unwinding in several successions.

257 otes activation of TOR, and thus translation reinitiation of uORF-containing mRNAs.

258 formation, thereby preventing the post-shock reinitiation of ventricular fibrillation.

259 of actin) was used as an intervention after reinitiation of vesicular transport.

260 Reactivation from latency requires reinitiation of viral gene expression and culminates in

261 NA replication, thereby preventing premature reinitiations of chromosome replication.

262 translation initiation, promote translation reinitiation on a specific set of mRNAs with short upstr

263 initiator moieties are deactivated to avoid reinitiation on existing brushes.

264 nit joining to influence AUG recognition and reinitiation on GCN4 mRNA.

265 ype BLM and hRPA was necessary for unwinding reinitiation on hRPA-coated DNA.

266 initiation factor DENR promotes translation reinitiation on mRNAs harbouring upstream open reading f

267 ects are caused by aberrant viral polymerase reinitiation on the same viral RNA template (deletion DI

268 Here we model the effect of ribosome reinitiation on translation and show that, at high level

269 ypes of polymerase at either the initiation, reinitiation or both stages of the transcription cycle.

270 ROP2 coordinates TOR function in translation reinitiation pathways in response to auxin.

271 Reinitiation probably occurs through a different pathway

272 The multiple reinitiation process ensures rapid copying of the parent

273 (negative RNA2) hampers the reattachment and reinitiation processes.

274 to form a complex with PriA, the primosomal reinitiation protein.

275 translation and show that, at high levels of reinitiation, protein synthesis rates are dominated by t

276 ately 60 nucleotides/s for yeast Pol I and a reinitiation rate of less than 1 s on the most heavily t

277 polymerase could be a primary determinant of reinitiation rate, allowing diversity in promoter streng

278 no direct correlation between IR length and reinitiation rates but demonstrated that specific IR len

279 lear extract system was established in which reinitiation rates were observed to be kinetically facil

280 With resolution of stress, translation reinitiation reverses this process and SGs disassemble.

281 respond to an authentic VSV termination and reinitiation signal present at each gene junction, we re

282 dividual DI-RNAs, identified breakpoints and reinitiation sites, and predicted their structural featu

283 with an unintended translational termination-reinitiation (split) near the finger tip, dramatically i

284 and demonstrated that a coupled termination-reinitiation (stop-restart) strategy is indeed used.

285 les (SGs), wherein mRNAs undergo sorting for reinitiation, storage, or decay.

286 ity of a soluble factor that is limiting for reinitiation, that the factor increases the number of el

287 llowed by global impairment of transcription reinitiation through MTI.

288 progression, mortality, ART dropout, and ART reinitiation using a continuous-time multistate Markov m

289 We recapitulated reinitiation using a reconstituted mammalian translation

290 Efficient reinitiation was found to occur only if the eIF4F comple

291 II complexes in transcription initiation and reinitiation was investigated by supplementing extracts

292 initiate treatment, statin persistence after reinitiation was low.

293 the duration of elongation is what matters, reinitiation was nearly abolished when a pseudoknot that

294 g a purified system to examine transcription reinitiation, we found that Pol II-TFIIF was active in p

295 nt for observed rapid rates of transcription reinitiation were explored.

296 c region had a differential effect on F gene reinitiation, where some but not all nonviral sequences

297 the specific chemical probe does not affect reinitiation, which requires the re-entry of Pol II, thu

298 on, elongation and in termination-associated reinitiation with subunit C11.

299 e from ART discontinuation to the subsequent reinitiation within 18 months.

300 why nuclear permeabilization is required for reinitiation within one cell cycle.