ライフサイエンスコーパス: relapsing fever

1 lia species associated with Lyme disease and relapsing fever.

2 , another spirochete pathogen and a cause of relapsing fever.

3 ered species is a causal agent of tick-borne relapsing fever.

4 rrelia recurrentis, the agent of louse-borne relapsing fever.

5 of several spirochete species that can cause relapsing fever.

6 s of pathogenesis and immunity of tick-borne relapsing fever.

7 ess that can include meningoencephalitis and relapsing fever.

8 widespread human diseases, Lyme disease and relapsing fever.

9 sis, and B. hermsii, the agent of tick-borne relapsing fever.

10 ase, syphilis, leptospirosis, and tick-borne relapsing fever.

11 rsistence of Lyme borreliosis and tick-borne relapsing fever.

12 mission and pathogenesis of Lyme disease and relapsing fever.

13 a miyamotoi has recently been shown to cause relapsing fever.

14 of mammalian hosts, causing Lyme disease and relapsing fever.

15 oles in the pathogenesis of Lyme disease and relapsing fever.

16 Unlike Borrelia burgdorferi, the relapsing fever agent Borrelia hermsii and the related B

17 The antigenic variation of the relapsing fever agent Borrelia hermsii is associated wit

18 The relapsing fever agent Borrelia hermsii is transmitted by

19 The relapsing fever agent Borrelia hermsii undergoes multiph

20 proteins: VspB of B. turicatae, Vsp26 of the relapsing fever agent Borrelia hermsii, and OspC of the

21 deficiency (scid mice) and infected with the relapsing fever agent Borrelia turicatae develop manifes

22 The relapsing fever agent Borrelia turicatae has two antigen

23 ntly infected with isogenic serotypes of the relapsing fever agent Borrelia turicatae.

24 enic variation is similar to that of another relapsing fever agent, B. hermsii.

25 ent mice infected with Borrelia turicatae, a relapsing fever agent, have a disorder that resembles di

26 e vector-borne bacterium Borrelia hermsii, a relapsing fever agent, switches gene expression of a sur

27 smids 180 and 170 kb in size, present in the relapsing fever agents B. hermsii and B. turicatae but n

28 llow serological confirmation of louse-borne relapsing fever and determination of disease prevalence.

29 anism previously isolated from patients with relapsing fever and from ticks in Spain that is designat

30 The spirochaetes that cause tick-borne relapsing fever and Lyme disease are closely related hum

31 ochetes and help clarify the distribution of relapsing fever and Lyme disease in situations in which

32 n products serve functions essential to both relapsing fever and Lyme disease spirochetes.

33 ologic disease manifestations develop during relapsing fever and that T cells play a critical role in

34 ological agents known to cause Lyme disease, relapsing fever, and Borrelia miyamotoi disease.

35 persistent infections, such as anaplasmosis, relapsing fever, and sleeping sickness, remains untested

36 should be considered a hard-tick-transmitted relapsing fever, and thus, the main mode of confirming a

37 r human diseases, including epidemic typhus, relapsing fever, and trench fever.

38 Between 1996 and 1998, 12 cases of relapsing fever associated with two exposure sites in no

39 n B. miyamotoi, and the agent of louse-borne relapsing fever (B. recurrentis).

40 IL-10-deficient mice infected with the relapsing fever bacterium Borrelia turicatae rapidly suc

41 Analysis of another relapsing fever bacterium, B. parkeri, indicated that it

42 ividual episodes of bacteremia caused by the relapsing fever bacterium, Borrelia hermsii.

43 ch pathogens, we studied Borrelia hermsii, a relapsing fever bacterium.

44 e that some Borrelia species associated with relapsing fever bind fH, but not those associated with a

45 Bacteria were the most common, with relapsing fever Borrelia and spotted fever Rickettsia fo

46 burgdorferi, the agent of Lyme disease, and relapsing fever Borrelia in the absence of complement.

47 udies have shown that antigenic variation in relapsing fever Borrelia not only permits the evasion of

48 stigated during the course of infection of a relapsing fever Borrelia species in plasminogen-deficien

49 l Spanish isolates of SRF Borrelia and other relapsing fever Borrelia species.

50 estations in humans depends on the infecting relapsing fever Borrelia species.

51 ular and linear plasmids of Lyme disease and relapsing fever Borrelia spirochetes carry genes for mem

52 Relapsing fever Borrelia spp. undergo antigenic variatio

53 e for the PAS in heart and brain invasion by relapsing fever Borrelia, resulting in organ injury.

54 endent bactericidal monoclonal IgM against a relapsing fever Borrelia, was constructed to investigate

55 served in the plasma of mice infected with a relapsing fever borrelia.

56 th during the cell cycle is also observed in relapsing fever Borrelia.

57 role for MyD88 signaling in host defense to relapsing fever Borrelia.

58 fect of nonantibody, innate host defenses to relapsing fever Borrelia.

59 e B. burgdorferi sensu lato isolates and the relapsing-fever Borrelia species.

60 c similarity and include agents of soft-tick relapsing fever (Borrelia hermsii and others), the emerg

61 The Lyme disease (Borrelia burgdorferi) and relapsing-fever (Borrelia hispanica) agents have distinc

62 Relapsing fever borreliae replicate to high levels in th

63 To evade the human host's immune response, relapsing fever borreliae, including B. miyamotoi, produ

64 cytopenia is common in persons infected with relapsing fever Borreliae.

65 tem that closely resembles the VMP system of relapsing fever borreliae.

66 5-like antigen genes and are conserved among relapsing fever borreliae.

67 We conclude that persistent infection with relapsing fever borrelias causes significant loss of car

68 Relapsing fever borreliosis is a multisystemic infection

69 nificant injury during experimental Lyme and relapsing fever borreliosis when the immune response is

70 During relapsing fever borreliosis, a high pathogen load in the

71 pathogen load, as during peak bacteremia in relapsing fever borreliosis, IL-10 protects innate immun

72 M required for the control and resolution of relapsing fever borreliosis.

73 (JHR) observed after antibiotic treatment of relapsing fever caused by Borrelia recurrentis is associ

74 Tick-borne relapsing fever caused by the spirochaete Borrelia dutto

75 Tick-borne relapsing fever, caused by pathogenic Borrelia such as B

76 Relapsing fever, caused by the spirochete Borrelia herms

77 on, whereas the role of adaptive immunity to relapsing fever-causing spirochetes is well documented,

78 g termed FbpC, which is found exclusively in relapsing fever-causing spirochetes, remains unknown.

79 ecurrentis genomes, the agent of louse-borne relapsing fever, dating from 2300 to 600 years ago.

80 of the Borrelia genus, which cause Lyme and relapsing fever diseases.

81 k of disease caused by tick- and louse-borne relapsing fever due to Borrelia infection is cyclic febr

82 continuous monitoring in an animal model of relapsing fever due to Borrelia infection.

83 To evaluate the pathogenesis of relapsing fever due to spirochetes in an animal model cl

84 s, pentoxifylline treatment of patients with relapsing fever fails to prevent or diminish JHR or the

85 l test antigen for discriminating tick-borne relapsing fever from Lyme disease.

86 The recent discovery of emerging relapsing fever group Borrelia (RFGB) species, such as B

87 confirmed the presence of these genes in the relapsing fever group of spirochetes but not in B. burgd

88 Relapsing fever group species are found worldwide, excep

89 B. lonestari is more closely related to the relapsing fever group spirochetes than to borreliae that

90 , a spirochete that is classified within the relapsing-fever group of spirochetes.

91 the Western Front reported on a soldier with relapsing fever, headache, dizziness, lumbago, and shin

92 as a human pathogen causing hard tick-borne relapsing fever (HTBRF) across the Northern Hemisphere.

93 Abs are protective against Lyme disease and relapsing fever, illnesses caused by Borrelia spirochete

94 Therefore, the potential for tick-borne relapsing fever in humans and other animals exists in Fl

95 relia hermsii, a spirochaete responsible for relapsing fever in humans, grows to high density in the

96 The spirochetemia of relapsing fever in mice is cleared by a complement-indep

97 ations for understanding the epidemiology of relapsing fever in North America and can be applied to t

98 The primary causative agent of tick-borne relapsing fever in North America is Borrelia hermsii.

99 hermsii, an etiological agent of tick-borne relapsing fever in North America, binds host-derived ser

100 the primary etiological agent of tick-borne relapsing fever in North America, binds the complement r

101 a hermsii is the primary cause of tick-borne relapsing fever in North America.

102 Relapsing fever is a common clinical phenotype.

103 Relapsing fever is also associated with the infection of

104 Relapsing fever is an acute febrile illness with promine

105 Relapsing fever is an infection characterized by peaks o

106 Relapsing fever is associated with high-level bacteremia

107 Tick-borne relapsing fever is caused by numerous Borrelia species m

108 se findings suggest that thrombocytopenia of relapsing fever is the result of platelet clearance afte

109 Agents that cause Lyme disease, relapsing fever, leptospirosis, and syphilis belong to t

110 strong contrast to the diagnosis of typical relapsing fever, microscopy of blood smears is not sensi

111 era from individuals with syphilis (n = 43), relapsing fever (n = 8), Lyme disease (n = 8), and lepto

112 Human louse-borne relapsing fever occurs in sporadic outbreaks in central

113 ng sera of patients suspected to have either relapsing fever or Lyme disease.

114 tein (vmp) system for antigenic variation of relapsing fever organisms.

115 e propose to use strain SP1, isolated from a relapsing fever patient in 1994 in southern Spain, as th

116 Immunoblot analyses demonstrated that relapsing fever patients produced antibodies to Mlp prot

117 Serum samples from relapsing fever patients reacted with recombinant PBH-51

118 ic cross-reactivity (98% if the samples from relapsing fever patients were excluded).

119 Relapsing fever pattern was reported in 52% of patients,

120 Relapsing fever pattern was reported in 52%, weight loss

121 that Borrelia hermsii, a causative agent of relapsing fever, produces a factor H (FH) and FH-like pr

122 nship with borreliae causing Lyme disease or relapsing fever remains undescribed.

123 aracterize surface proteins expressed by the relapsing fever (RF) agent Borrelia hermsii in the blood

124 orthologous thymidylate synthase gene in the relapsing fever (RF) agent Borrelia hermsii, located it

125 Surface-exposed lipoproteins of relapsing fever (RF) and Lyme borreliosis Borrelia spiro

126 Borrelia species of relapsing fever (RF) and Lyme disease (LD) lineages have

127 The relapsing fever (RF) borreliae encompass both establishe

128 Tick-borne relapsing fever (RF) borreliosis is a neglected disease

129 ement is common in the spirochetal infection relapsing fever (RF) in both humans and experimental ani

130 a variety of species of Borrelia that cause relapsing fever (RF) in humans.

131 Relapsing fever (RF) is a multisystemic spirochetal infe

132 Relapsing fever (RF) is a spirochetal infection characte

133 Relapsing fever (RF) is a spirochetal infection characte

134 Relapsing fever (RF) is caused by tick- and louse-borne

135 Borrelia hermsii and other relapsing fever (RF) species are noted for their highly

136 The global public health impact of relapsing fever (RF) spirochetosis is significant, since

137 ausative agents of Lyme borreliosis (LB) and relapsing fever (RF).

138 orreliosis (LB) group Borrelia species and 7 Relapsing-fever (RF) group Borrelia species.

139 previously described BBK32-like proteins in relapsing fever species, indicates that BHA007 is a memb

140 arly after infection, Borrelia crocidurae, a relapsing fever species, induced a striking loss of marg

141 he vlp/vsp antigenic variation system of the relapsing fever spirochaete, Borrelia hermsii.

142 icatae directly promoted GAG binding by this relapsing fever spirochaete.

143 Thus, relapsing fever spirochaetes have the potential to expre

144 esponse and contribute to the ability of the relapsing fever spirochaetes to achieve high cell densit

145 minoglycans (GAGs) mediate the attachment of relapsing fever spirochaetes to mammalian cells.

146 GAGs mediated the attachment of relapsing fever spirochaetes to potentially relevant tar

147 Genome sequencing of two species of relapsing fever spirochaetes, Borrelia hermsii and Borre

148 ein and enzymatic activity were found in all relapsing fever spirochaetes, but not in Lyme disease or

149 s a unique and functional serine protease in relapsing fever spirochaetes.

150 rtant contributor to the pathogenesis of the relapsing fever spirochete B. hermsii.

151 cA of B. burgdorferi, as well as RecA of the relapsing fever spirochete Borrelia hermsii and the free

152 We previously showed that the relapsing fever spirochete Borrelia hermsii binds to and

153 The tick-borne relapsing fever spirochete Borrelia hermsii evades the m

154 Serotypes A and B of the relapsing fever spirochete Borrelia turicatae produce di

155 ed with serotype A but not serotype B of the relapsing fever spirochete Borrelia turicatae, early inv

156 the Borrelia parkeri-B. turicatae tick-borne relapsing fever spirochete group with a late-term aborti

157 Borrelia miyamotoi is a relapsing fever spirochete in Ixodes ticks that has been

158 Some Lyme disease and relapsing fever spirochete species bind factor H to thei

159 Borrelia miyamotoi is a relapsing fever spirochete that relatively recently has

160 ted the polyclonal IgM Ab response against a relapsing fever spirochete to determine the specificity

161 Borrelia miyamotoi, a relapsing fever spirochete transmitted by Ixodid ticks c

162 Lyme disease spirochete) and B. turicatae (a relapsing fever spirochete).

163 The relapsing fever spirochete, Borrelia hermsii, alternates

164 The relapsing fever spirochete, Borrelia hermsii, escapes im

165 B. turicatae, confirming this bacterium as a relapsing fever spirochete.

166 urgdorferi sensu stricto strain CA4, and the relapsing-fever spirochete B. parkeri (undesignated).

167 ed characterization of the Bdr proteins in a relapsing-fever spirochete species, enhancing our unders

168 Borrelia hermsii, a tick-borne relapsing-fever spirochete, contains orthologs to glpQ a

169 the bdr gene family of Borrelia turicatae, a relapsing-fever spirochete.

170 n will identify people exposed previously to relapsing fever spirochetes and help clarify the distrib

171 standing of the pathogenic mechanisms of the relapsing fever spirochetes and of the molecular nature

172 ay be involved in the pathogenicity of these relapsing fever spirochetes and provide a mechanism for

173 , and Borrelia afzelii strains as well as in relapsing fever spirochetes Borrelia hermsii and Borreli

174 Genome sequencing of the relapsing fever spirochetes Borrelia hermsii and Borreli

175 infected with B. hermsii or other species of relapsing fever spirochetes contained antibodies recogni

176 The relapsing fever spirochetes contained six open reading f

177 s complete pathway for purine salvage in the relapsing fever spirochetes may contribute, in part, to

178 poproteins are serotype-defining antigens of relapsing fever spirochetes that undergo multiphasic ant

179 poproteins are serotype-defining antigens of relapsing fever spirochetes that undergo multiphasic ant

180 Genome sequencing projects on two relapsing fever spirochetes, Borrelia hermsii and Borrel

181 rrelia miyamotoi, a member of the tick-borne relapsing fever spirochetes, shows a serum-resistant phe

182 disease, B. miyamotoi is closely related to relapsing fever spirochetes, such as Borrelia hermsi i S

183 molecular mechanisms of pathogenesis of the relapsing fever spirochetes.

184 from but most closely related to that of the relapsing fever spirochetes.

185 systems for the genetic manipulation of the relapsing fever spirochetes.

186 icipate in long-lasting immunity to Lyme and relapsing fever spirochetes.

187 discernible ortholog to the hpt gene in the relapsing fever spirochetes.

188 tion and pathogen load during infection with relapsing fever spirochetes.

189 Relapsing-fever spirochetes achieve high cell densities

190 losely related sequence) is multicopy in the relapsing-fever spirochetes and is carried on variably s

191 s of borreliae demonstrated GlpQ activity in relapsing-fever spirochetes but not in Lyme disease spir

192 hern blots demonstrated glpQ and glpT in all relapsing-fever spirochetes but not in the Lyme disease

193 zation of a gene from B. turicatae and other relapsing-fever spirochetes that exhibits homology with

194 The unique ability of relapsing-fever spirochetes to hydrolyze phospholipids m

195 The complexity of disease caused by relapsing-fever spirochetes was demonstrated in the nonh

196 ssible importance in the pathogenesis of the relapsing-fever spirochetes.

197 with the glpQ sequences obtained from other relapsing-fever spirochetes.

198 icks in Spain that is designated the Spanish relapsing fever (SRF) Borrelia.

199 texposure prophylaxis regimen for tick-borne relapsing fever (TBRF) consists of 5 days' doxycycline.

200 Tick-borne relapsing fever (TBRF) is a neglected zoonotic bacterial

201 Tick-borne relapsing fever (TBRF) is a spirochetal disease caused b

202 Tick-borne relapsing fever (TBRF) is caused by several Borrelia spp

203 In North America, tick-borne relapsing fever (TBRF) is caused by the spirochete speci

204 ); and Borrelia recurrentis, responsible for relapsing fever transmitted by body lice.(8) We were not

205 a relapse followed febrile illness caused by relapsing fever, trench fever, epidemic typhus, and Malt

206 Borrelia hermsii, an agent of relapsing fever, undergoes antigenic variation of seroty

207 chaetes, although similar in sequence to the relapsing fever vlp genes, has evolved a completely diff

208 The structures confirm that relapsing fever Vsp proteins share a common helical fold

209 Borrelia hermsii, an agent of tick-borne relapsing fever, was found to contain multiple circular

210 To develop a specific serological test for relapsing fever, we created a genomic DNA library of B.

211 Fifteen patients with confirmed relapsing fever were infused intravenously with pentoxif

212 s obtained from 42 patients with louse-borne relapsing fever were tested with an indirect immunofluor

213 Borrelia hermsii, agents of Lyme disease and relapsing fever, were examined by epifluorescence micros

214 ination of spirochetemia in murine models of relapsing fever, without the assistance of complement.