ライフサイエンスコーパス: releasable

1 e to extracellular protease and is detergent releasable.

2 ent led to AbetaO binding that was no longer releasable.

3 th low probability despite being immediately releasable.

4 l of ~1800 SVs with strikingly large readily releasable (~20), recycling (~80) and resting pools (~85

5 ted terminals relies on well-defined readily releasable and cytoplasmic vesicle pools.

6 lay a kinetic defect in refilling of readily releasable and immediately releasable vesicle pools (RRP

7 educed or undetectable, suggesting that both releasable and membrane-bound alpha-granule constituents

8 ially targets the transporter to the readily releasable and recycling pool of vesicles.

9 y area and number of vesicles in the readily releasable and recycling pools, all correlated with incr

10 tion, a Ca(2)(+) sensitive K(+) current, and releasable and reserve pools of vesicles.

11 ptic vesicle recycling, and enlarged readily-releasable and reserved vesicle pools.

12 A model that accounts for the releasable and unreleasable components of MWNTs was used

13 e demonstrate the generation of systemically releasable anti-cancer drugs from multilayer nanofilms.

14 We show that sphingosine, a releasable backbone of sphingolipids, activates synaptob

15 e aging (AR) and analyzed for free and Brine Releasable (BR) VSCs and redox potential.

16 Brine-releasable (BR-) and free fractions of Volatile Sulfur C

17 response to strong stimulation and were also releasable by hypertonic sucrose.

18 terminal by providing both a local source of releasable Ca and by effects on luminal Ca-dependent RyR

19 reticulum (SR) Ca(2+) release and maximal SR-releasable Ca(2+) contributes to decreased specific forc

20 d junctional SR, and 2), the availability of releasable Ca(2+) in the junctional SR.

21 Quantification of caffeine-releasable Ca(2+) pools consistently showed larger centr

22 Importantly, this decrease in releasable Ca(2+) store content observed after exercise

23 y coincident with a modest decrease in total releasable Ca(2+) store content.

24 ochondria that reduces the available pool of releasable Ca(2+) within the ER, thereby inhibiting calc

25 -contraction coupling, but not in maximal SR-releasable Ca(2+), account for the age-dependent decline

26 hat regulates PDG luminal pH and the pool of releasable Ca(2+).

27 lished the effect of thapsigargin on the IP3-releasable Ca2+ pool.

28 The difference suggests that 75% of the releasable calcium is normally bound to calsequestrin.

29 een wild-type and Cmpt fibers, the amount of releasable calcium was significantly reduced in the latt

30 In course of time, the amount of releasable compounds decreased, pointing to altering pro

31 (w,0)) in the pore water and the accessible (releasable) concentration in the sediment (C(as,0)) are

32 The releasable conjugate regenerated Luminespib activity and

33 d toward overcoming such limitations through releasable conjugates in which the drug is covalently li

34 In conclusion, CC could be active, releasable contributors to thrombosis by inducing monocy

35 the production of an NMDA receptor-dependent releasable copper pool within hippocampal neurons, a fin

36 e Lewis Cliff 85311 meteorite shows that its releasable cyanide is primarily in the form of [Fe(II)(C

37 lls were grown on arrays of microfabricated, releasable elements composed of SU-8 polymer termed "cel

38 prior methods for creating cell arrays with releasable elements, no chemical modification of the sub

39 icated that Mn reduced the available pool of releasable ER Ca(2+) at concentrations as low as 1 muM.

40 The releasable factor adenosine blocks the formation of long

41 n=12) annuloplasty rings were implanted in a releasable fashion.

42 n=12) annuloplasty rings were implanted in a releasable fashion.

43 These results demonstrate that releasable FIX can be expressed and stored in platelet a

44 cytoplasmically sequestered 5-HT is readily releasable from both COS-7 cells and the guinea pig ileu

45 eal and bacterial lipids relative to what is releasable from their respective high-pressure catalytic

46 t not thalamic input, enhanced the number of releasable GABAergic synaptic vesicles and morphological

47 ranule exocytosis, facilitating refilling of releasable granule pools while also limiting the rate of

48 ells reduced the Ca(2+) content of ionomycin-releasable intracellular stores and decreased endoplasmi

49 re we describe the synthesis of a chemically releasable, irreversible K(+) channel inhibitor and its

50 te peptide and TAT were conjugated through a releasable linker, either a disulfide or photolabile bon

51 a PEG(40kDa) carrier via a beta-eliminative releasable linker.

52 The releasable linkers provide additional benefits that incl

53 Myocardial heparin-releasable lipoprotein lipase (LPL) activity was moderat

54 the plasma membrane and associates in an ATP-releasable manner to the actin-containing insoluble pell

55 thioglycollate, greater pools of epinephrine-releasable marginated neutrophils, greater sensitivity t

56 e that the RH5Nt-P113 interaction provides a releasable mechanism for anchoring RH5 to the merozoite

57 Arrays of transparent, releasable micrometer-scale structures termed "microcups

58 ibed is the construction of a large array of releasable microstructures (micropallets) along with scr

59 mor cells from whole blood using an array of releasable microstructures termed micropallets.

60 viding an array of approximately 1.3 million releasable microstructures.

61 -based assay with covalently immobilized but releasable misfolded protein to obviate possible chapero

62 For comparable cytoplasmic Ca(2+) loads, the releasable mitochondrial Ca(2+) in SNL L5 neurons was le

63 ased and the release rate coefficient of the releasable MWNTs also increased.

64 ancer cell lines, can be incorporated into a releasable octaarginine conjugate that is effective agai

65 od was stored in platelets, most of which is releasable on activation of platelets.

66 e variety of cargo attachment strategies for releasable or nonreleasable transporter applications.

67 hanges in either the size or mobilization of releasable or reserve pools, and (3) a decrease in rabph

68 vidence of these intracellular DPPs cleaving releasable peptides, such as NPY, in live cells.

69 ch epidermis, using microneedles coated with releasable polyelectrolyte multilayers.

70 st consisting of IL-2 conjugated to multiple releasable polyethylene glycol chains resulting in susta

71 This immediately releasable pool (IRP) of granules, identified both struc

72 endence of the effective size of the readily releasable pool (RRP) also contributes to the calcium de

73 nge applies to the release of both a readily releasable pool (RRP) and a slower secondary pool of ves

74 in release probability (Pr ) and/or readily-releasable pool (RRP) in many synapses, but the role of

75 in release probability (Pr ) and/or readily-releasable pool (RRP) in many synapses, but the role of

76 ted in a significant increase in the readily releasable pool (RRP) of secretory granules, and decreas

77 tion of the rate of refilling of the readily releasable pool (RRP) of secretory granules.

78 ed to a reduction in the size of the readily releasable pool (RRP) of SVs.

79 in release probability (Pr ) and/or readily-releasable pool (RRP) of synaptic vesicles (SVs), but th

80 flux, and diminishes the size of the readily-releasable pool (RRP) of synaptic vesicles, consistent w

81 with an increase in the size of the readily releasable pool (RRP) of synaptic vesicles, consistent w

82 eed the rate of replenishment of the readily releasable pool (RRP) of synaptic vesicles, depression o

83 lutions that measure the size of the readily releasable pool (RRP) of synaptic vesicles.

84 letion of synaptic vesicles from the readily releasable pool (RRP) of transmitter.

85 ggested that complexin maintains the readily releasable pool (RRP) of vesicles and clamps spontaneous

86 but does not change the size of the readily-releasable pool (RRP) of vesicles as measured by stimula

87 The readily releasable pool (RRP) of vesicles is a core concept in s

88 The size of the readily releasable pool (RRP) of vesicles is critically importan

89 uIPSCs in granule cells to evaluate readily releasable pool (RRP) size and resupply rate of recyclin

90 ow that another presynaptic feature, readily releasable pool (RRP) size, is tonotopically distributed

91 l fate of vesicles endocytosed after readily releasable pool (RRP) stimulation in rat hippocampal syn

92 cytosis recycles vesicles within the readily releasable pool (RRP) via a kiss-and-run mechanism that

93 ascent synapses without a functional readily releasable pool (RRP) was unresponsive to PMA applicatio

94 acilitates release efficacy from the Readily Releasable Pool (RRP), and regulates SV distribution to

95 r component) after exocytosis of the readily releasable pool (RRP).

96 comitant increase in the size of the readily releasable pool (RRP).

97 pses by a high-calcium stimulus, the readily releasable pool (RRP).

98 tivated for transmitter release, the readily releasable pool (RRP).

99 ependent increase in the size of the readily releasable pool (RRP).

100 st and slow releasing SVs within the readily releasable pool (RRP).

101 ainly control the fast fusion of the readily releasable pool (RRP); that is, they encode the phasic e

102 , and redirecting them to refill the readily releasable pool after relaxation of the calcium signal.

103 tic vesicles were detected: a small, rapidly releasable pool and a larger and more slowly releasable

104 in Rett syndrome (RTT), but the state of its releasable pool and downstream signaling in mice lacking

105 n (GSIS) resulting from reduction in readily releasable pool and granule pool refilling.

106 aptic vesicle pools, including the immediate releasable pool and the ready releasable pool-key elemen

107 ltaneously released vesicles) in the readily releasable pool and their replenishment time constant ca

108 s associated with a reduction in the readily releasable pool and vesicle recycling which impaired the

109 at Epac2 is required to maintain the readily releasable pool at MF synapses in the hippocampus.

110 n of docked synaptic vesicles into a readily releasable pool by activating SNAREs for efficient membr

111 in this system replenishment of the readily releasable pool by the reserve vesicles was strictly GTP

112 probability, and (2) the size of the readily releasable pool exclusively at excitatory synapses in mi

113 tosis of synaptic vesicles after the readily releasable pool has either been physiologically exhauste

114 e size and replenishment rate of the readily releasable pool in autaptic neurons.

115 f release, and the number of vesicles in the releasable pool is comparable to the number of vesicles

116 availability of an NMDA receptor-dependent, releasable pool of copper in hippocampal neurons and dem

117 ethyl-p-tyrosine, which depletes the readily releasable pool of dopamine, cocaine was still capable o

118 brane-attached vesicles comprise the readily releasable pool of fusion-competent vesicles and that sy

119 ression to endothelial cells may establish a releasable pool of FVIII and normalize plasma FVIII leve

120 Further, the readily releasable pool of GABA vesicles and the release probabi

121 esicles but regulate the size of the readily releasable pool of GABAergic vesicles.

122 ned to test whether there are changes in the releasable pool of GnRH in the hypothalamus in response

123 KO mice due to impaired replenishment of the releasable pool of granules and that the Ide gene is hap

124 sing from an increase in size of the readily releasable pool of insulin SGs and enhanced SG pool refi

125 exo-endocytosis, they populate a reluctantly releasable pool of limited size.

126 ted that estradiol increases the potentially releasable pool of NPY in inhibitory presynaptic boutons

127 l GTPase in reducing the size of the readily releasable pool of SVs and in channeling retrieved SVs t

128 esicle dispersion did not affect the readily releasable pool of SVs, whereas the total number of SVs

129 The segregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools

130 Ca(2+) channels and the size of the readily releasable pool of synaptic vesicles at active zones.

131 s release and limits the size of the readily-releasable pool of synaptic vesicles at the active zone

132 d docking and their loss reduces the readily releasable pool of synaptic vesicles by up to 75%.

133 ng the homeostatic modulation of the readily releasable pool of synaptic vesicles following inhibitio

134 revealed that pregabalin reduces the readily releasable pool of synaptic vesicles in an N-methyl-d-as

135 and acceptor vesicles, mimicking the readily releasable pool of synaptic vesicles prior to an action

136 e size and replenishment rate of the readily releasable pool of synaptic vesicles without changes in

137 al extent of evoked release, size of readily releasable pool of synaptic vesicles, and release probab

138 forms, SV2A and SV2B, have a reduced readily releasable pool of synaptic vesicles, indicating that SV

139 nt of synaptotagmin 1 suppressed the readily releasable pool of synaptic vesicles, whereas wild-type

140 ngth, by stabilizing the size of the readily releasable pool of synaptic vesicles.

141 BK channels, and an increase in the readily releasable pool of synaptic vesicles.

142 tosis efficiency and the size of the readily releasable pool of synaptic vesicles.

143 le replenishment, and increasing the readily releasable pool of synaptic vesicles.

144 leased synchronously with the normal readily releasable pool of synaptic vesicles.

145 nce between the reserve pool and the readily releasable pool of synaptic vesicles.

146 release probability and size of the readily releasable pool of the synapse.

147 ynaptic currents and the size of the readily releasable pool of transmitter.

148 hapsigargin or cyclopiazonic acid primes the releasable pool of vasopressin in the dendrites, so that

149 lease-ready vesicles from an unusually large releasable pool of vesicles (approximately 300 per site)

150 e hearing onset, and by an increased readily releasable pool of vesicles (RRP) thereafter.

151 believed to mobilize sequentially a readily releasable pool of vesicles (RRP) underneath the synapti

152 The readily releasable pool of vesicles (RRP) varies in size during

153 EPSCs and decreased the size of the readily releasable pool of vesicles (RRP).

154 underneath the synaptic ribbons and a slowly releasable pool of vesicles (SRP) at farther distance fr

155 evented decreases in the size of the readily releasable pool of vesicles and in the percentage of act

156 1 which results in a decrease in the readily releasable pool of vesicles at a synapse, suggesting tha

157 size, but not the properties, of the readily-releasable pool of vesicles at inhibitory synapses.

158 r, with adaptation, depletion of the readily releasable pool of vesicles diminishes quantal content a

159 ritical for the proper maturation of readily releasable pool of vesicles during early development but

160 onous release completely empties the readily releasable pool of vesicles during sustained elevations

161 ce PTP by increasing the size of the readily releasable pool of vesicles evoked by high-frequency sti

162 rains of activity suggested that the readily releasable pool of vesicles is reduced in Epac2(-/-) mic

163 After neurotransmission, the readily releasable pool of vesicles must be refilled in less tha

164 lpha causes a large reduction in the readily releasable pool of vesicles, alters short-term plasticit

165 to an alteration of the size of the readily releasable pool of vesicles, but are attributable to red

166 mini frequency, mini amplitude, the readily releasable pool of vesicles, or the apparent Ca(2+) sens

167 I mutations reduced the size of the readily releasable pool of vesicles, whereas the region II mutat

168 ed vesicles did not preferentially enter the releasable pool of vesicles.

169 up to 2-fold, with no effect on the readily releasable pool of vesicles.

170 nts in motor neurons and an enlarged readily releasable pool of vesicles.

171 erve pool first and subsequently the readily releasable pool over a period of several minutes.

172 voked-release amplitudes (indicating readily-releasable pool refilling) occurred within approximately

173 obilization and replenishment of the readily releasable pool require GTP and Ca2+ but do not necessit

174 ion revealed that as P declines, the readily releasable pool size (N) increases so that the net EPSC

175 Consistently, the readily releasable pool size and formation of SNARE complexes ar

176 near active zones (AZs) predict the measured releasable pool size and replenishment rate from the res

177 ponse fitting of Stx1 levels against readily releasable pool size and vesicular release probability s

178 ther recent evidence links alteration of the releasable pool size with changes in p(r), our results s

179 is overshoot, but did not affect the readily releasable pool size, Ca(2+) influx, or exocytosis.

180 paired, as demonstrated by a smaller readily releasable pool size, slower refilling rate of primed ve

181 tic calcium channel localization and readily releasable pool size.

182 eplenishment mechanisms but also by altering releasable pool size.

183 evoked release with no change in the readily releasable pool size.

184 synaptic ribbons participate in the readily releasable pool that is tapped rapidly during depolariza

185 d Tomo1 actions to extend beyond the Readily Releasable Pool to mediate the Total Recycling Pool and

186 Doc2b, release was shifted from the readily releasable pool to the subsequent sustained component.

187 nor the timing of recruitment to the readily releasable pool was affected.

188 nt was largely inhibited whereas the readily releasable pool was augmented.

189 ration train, which interrogates the readily releasable pool, but depleted release elicited by a long

190 ith low release probability, a large readily releasable pool, fast presynaptic calcium clearance and

191 l close to the calcium channels (immediately releasable pool, IRP).

192 ilitated vesicle mobilization to the readily releasable pool, probably by clearing fused vesicle memb

193 ased is regulated by the size of the readily-releasable pool, upstream of vesicle release probability

194 the immediate releasable pool and the ready releasable pool-key elements of short-term plasticity th

195 vert docked synaptic vesicles into a readily releasable pool.

196 ility of release and the size of the readily releasable pool.

197 ng of synaptic vesicles back to the nonready releasable pool.

198 g the reserve pool and enhancing the readily releasable pool.

199 is required for the full size of the readily releasable pool.

200 oot pool approximately 1.8 times the readily releasable pool.

201 release preferentially involves the readily releasable pool.

202 terminals, reducing release from the readily releasable pool.

203 l-known exponential refilling of the readily releasable pool.

204 les, presumably corresponding to the readily releasable pool.

205 dual evoked release and rescuing the readily-releasable pool.

206 utative regulator of the presynaptic Readily Releasable Pool.

207 hibited vesicle replenishment to the readily releasable pool.

208 hibited vesicle replenishment to the readily releasable pool.

209 inhibits vesicle mobilization to the readily releasable pool.

210 releasable pool and a larger and more slowly releasable pool.

211 netics upon intense activity and the readily releasable pool.

212 ficient mutants-restores the size of the the releasable pools in knockout cells, and in WT cells it m

213 ue to a reduction of cytoplasmic and readily releasable pools of vesicles.

214 atter indicating defects in replenishment of releasable pools required to sustain second-phase GSIS.

215 cle pools (comprising the readily and slowly releasable pools), while showing no change in the kineti

216 lting from a decreased number of vesicles in releasable pools.

217 ntact with platelets but is mediated through releasable products, namely IL-1beta.

218 g was mediated through surface components or releasable products, platelets were pretreated with an i

219 alpha-granules constitute the major rapidly releasable reservoir of thrombospondin-1 in higher anima

220 re dominant function in the replenishment of releasable SG pools in human beta-cells than its previou

221 idative stress, which, in turn, increase the releasable soluble pool of cytochrome c within the mitoc

222 ol priming of synaptic vesicles to a readily releasable state, and interact with each other via their

223 potential waveforms, Ca(2+) influx, readily releasable SV pool size, and quantal size were unaltered

224 ed, leading to a progressive loss of readily releasable SVs and abnormal neurotransmission.

225 ic release of neurotransmitters from readily releasable synaptic vesicles (SVs) at the active zone.

226 on of intracellular Ca(2+) and diminution of releasable synaptic vesicles.

227 as only encountered for hydrogels containing releasable, target-specific siRNAs, accompanied by minim

228 The correlation with standard methods for releasable TCA quantification is also discussed.

229 Using releasable tethered Clr4 reveals that an active process

230 ycling, which constitutes the main source of releasable transmitter at glycinergic synapses.

231 tumor responses, we utilized charge-altering releasable transporters (CART) for local intratumoral de

232 tic biodegradable materials: charge-altering releasable transporters (CARTs) for mRNA delivery into c

233 s, oligo(serine ester)-based charge-altering releasable transporters (Ser-CARTs).

234 decreased probability of releasing a readily releasable vesicle during an action potential.

235 largely attributed to depletion of a readily releasable vesicle pool (RRP) and a decreased probabilit

236 Light-evoked depletion of the readily releasable vesicle pool (RRP) at rod bipolar cell ribbon

237 s) and did not alter the size of the readily releasable vesicle pool (RRP), the kinetics of RRP deple

238 nflux, and (3) limited access to the readily releasable vesicle pool (RRP).

239 Surprisingly, despite a smaller readily releasable vesicle pool and fewer docked vesicles, a str

240 UMOylatable mutant decreases the size of the releasable vesicle pool and impairs stimulated SV exocyt

241 his enzyme caused a reduction of the readily releasable vesicle pool and its refilling rate, with a s

242 ing upregulates replenishment of the readily releasable vesicle pool during high-frequency firing.

243 h the rapidly releasing vesicle pool and the releasable vesicle pool of the retinal bipolar cell are

244 ld, without altering the presynaptic readily-releasable vesicle pool or postsynaptic neurotransmitter

245 ticity is mediated by an increase in readily releasable vesicle pool size and is extended in the abse

246 We show that modulations of readily releasable vesicle pool size and release probability nor

247 e probability per vesicle and larger readily releasable vesicle pool size at synapses onto interneuro

248 orms of short-term plasticity of the readily releasable vesicle pool size, release probability per ve

249 aptic transmission by increasing the readily releasable vesicle pool size; these mutants also increas

250 (Open) synapses, and the size of the readily releasable vesicle pool was decreased; however, the rate

251 lso facilitates replenishment of the readily releasable vesicle pool, likely via endocytic clearance

252 te without affecting the size of the readily releasable vesicle pool, linking C1 domain activation to

253 P-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate o

254 ore Munc18-1 after stimulation have a larger releasable vesicle pool.

255 al content but reduces the size of the ready-releasable vesicle pool.

256 of Munc13-3 nor replenishment of the readily releasable vesicle pool.

257 cytosis, but not for the size of the readily releasable vesicle pool.

258 so underlie the developmental control of the releasable vesicle pool.

259 with the comparable reduction of the readily releasable vesicle pool.

260 is accompanied by a partial recovery of the releasable vesicle pool.

261 ase without changing the size of the readily-releasable vesicle pool.

262 ld synapse decreased the size of the readily releasable vesicle pool.

263 is process lead to abnormal depletion of the releasable vesicle pool.

264 II knockout mice exhibit markedly diminished releasable vesicle pools (comprising the readily and slo

265 illing of readily releasable and immediately releasable vesicle pools (RRP and IRP, respectively) in

266 sence of Doc2b, the refilling of the readily releasable vesicle pools is faster, but incomplete.

267 iming of secretory vesicles and the sizes of releasable vesicle pools, but not vesicle fusion propert

268 trength is determined by the pool of readily releasable vesicles (RRP) and the probability of release

269 calcium channels and 1-10 (mean, 5) readily releasable vesicles (RRVs) and released 0-5 vesicles dur

270 In contrast, the readily releasable vesicles after depletion recover normally in

271 These satellite boutons contain releasable vesicles and normal complements of synaptic p

272 itter release is determined by the number of releasable vesicles and their probability of release.

273 The data suggest that readily releasable vesicles are retrieved as noncoated vesicles

274 atory synaptic drive, their pools of readily releasable vesicles are smaller, and transmission failur

275 urons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7

276 king and to enhance release probability, but releasable vesicles can be localized distant from the pr

277 sensory neurons must provide a large pool of releasable vesicles for sustained release, while minimiz

278 obilization of a small population of readily releasable vesicles is a Munc13-4-dependent but Rab27a-i

279 that synaptotagmin 2 helps to align readily releasable vesicles near calcium channels at nerve termi

280 Positioning releasable vesicles near voltage-gated calcium channels

281 mechanisms rapidly increasing the number of releasable vesicles reliably reproduce short-term plasti

282 Exocytosis of readily releasable vesicles remained unchanged, in accordance wi

283 13 and RIM and of docked vesicles, a pool of releasable vesicles remained.

284 of 30 ms depolarizations revealed that most releasable vesicles reside within 300 nm of the ribbon c

285 in receptor (SNARE)-driven fusion of readily releasable vesicles that are docked and primed at the pr

286 ransient insures the availability of readily releasable vesicles to support a second, sustained compo

287 The readily releasable vesicles were not clustered close to the pres

288 identified a highly Ca(2+)-sensitive pool of releasable vesicles with a relatively shallow relationsh

289 ion in the probability of release of readily releasable vesicles with both high and low release proba

290 elease probability and the number of readily releasable vesicles with no effects on the rate of recov

291 t7 mutants also had a larger pool of readily-releasable vesicles, faster recovery following stimulati

292 Neither the number of readily releasable vesicles, nor the timing of recruitment to th

293 e developed a method to assess the number of releasable vesicles, rate constants for vesicle priming,

294 ered the rapid fusion of a subset of readily-releasable vesicles, revealing a rapid role of PI(4,5)P2

295 of active zones and the continuous supply of releasable vesicles.

296 ng the effective size of the pool of readily releasable vesicles.

297 sistent with a smaller population of readily releasable vesicles.

298 inst preferential local reuse of the readily releasable vesicles.

299 d by 50-70%, demonstrating a loss of readily releasable vesicles.

300 The functional role of releasable Zn2+ in the central nervous system remains un