ライフサイエンスコーパス: release

1 ic reduction in presynaptic neurotransmitter release.

2 itochondrial BAX clustering and cytochrome c release.

3 ions with each cell type, alongside cytokine release.

4 lyte has been used to quantify intracellular release.

5 increases sFlt-1 and soluble endoglin (sEng) release.

6 promotes ATP hydrolysis and rapid phosphate release.

7 of inefficient clearance following synaptic release.

8 the mechanism responsible for conductive ATP release.

9 tin loops by protecting cohesin against loop release.

10 and the SNAREs in membrane fusion to trigger release.

11 rolled chemoattractant and therapeutic agent release.

12 lization inhibitor, that might afford better release.

13 ise spatial and temporal control over the CO release.

14 e uptake, phagolysosomal escape, and epitope release.

15 ction site, as well as the lack of prolonged release.

16 as not been previously investigated in HSV-1 release.

17 ntain SV pool size and thus neurotransmitter release.

18 K(+) (K(ATP) ) channels to increase insulin release.

19 TRPV4 contributed to 50% stretch-induced ATP release.

20 yed growth benefits to at least 1 month post release.

21 Release 2020_01 of UniProtKB contains 6496 UniRule rules

22 R848-TSLs released 80% of R848 within 5 min at 42 degrees C.

23 at only a subset of these are specialized to release acetylcholine.

24 wing antigen receptor stimulation are Ca(2+) release-activated Ca(2+) (CRAC) channels.

25 0.1 N HCl, while the CTX-OCT was completely released after 300 min in phosphate buffer pH 7.4.

26 essfully harnessed this novel radical strain-release amination as part of a multicomponent cascade co

27 sis infers the interaction between astrocyte-released amyloid precursor protein (APP) and death recep

28 eatment inhibited allergen-induced histamine release and airway contraction in guinea pig PCLS.

29 this pathway underscores asynchronous Ca(2+) release and arrhythmia.

30 Swabbing led to a smaller change in cortisol release and behaviour on the first day of analysis compa

31 chael addition, are not specific to O-glycan release and can also eliminate phosphoryl substitutions.

32 stration enhanced neurotrophic growth factor release and decreased the astroglial and microglial acti

33 Ex vivo, mast cell-mediated histamine release and degranulation was augmented upon TPC1 inhibi

34 ances L-DOPA uptake, leading to increased DA release and GSIS reduction in an autocrine/paracrine man

35 en receptor -alpha signaling increased IL-33 release and ILC2-mediated airway inflammation.

36 ired Pitx2 by preventing spontaneous calcium release and increasing wavelength.

37 volve cleavage with cathepsin B or papain to release and measure the antibody-conjugated drug (acDrug

38 However, cytokine release and microgliosis are consistently observed in AD

39 Yet, initial burst release and optimal modulation of the release profiles l

40 ses substantially increased neurotransmitter release and shortened sleep duration, and these effects

41 sing Cdk9 and either PP4 or PP1 govern pause release and the elongation-termination transition, respe

42 CM) to explore the kinetics of allograft sEV release and the extent to which donor sEVs might induce

43 -iron diets or Gpx4 depletion promotes 8-OHG release and thus activates the TMEM173/STING-dependent D

44 s well but also facilitates spontaneous GABA release and triggers an increase in the density of inhib

45 t or vehicle once or twice to evaluate IL-33 release and TSLP expression in the lung.

46 s adverse events were reported with capsular release and two with manipulation.

47 vating cell signaling, SOS autoinhibition is released and is followed by accelerative allosteric feed

48 nsitize cardiomyocytes to spontaneous Ca(2+)-releases and arrhythmogenic afterdepolarizations, partic

49 rable after enzyme opening and pyrophosphate release, and it appears to limit the rate of processive

50 tenuated RSV-induced HMGB1 translocation and release, and lowered viral load.

51 upported more efficient HIV-1 transcription, release, and replication.

52 t drug-loading capacity and inefficient drug release, and require complex modification processes.

53 c-acid rich glycocalyx also induced protease release, and this was partially abrogated by sialidase p

54 y, the reversible pH-responsive and non-drug release antibacterial resin adhesives ingeniously overco

55 alterations in spontaneous neurotransmitter release are a key factor to account for disease heteroge

56 their respective activation during glutamate release are still unclear.

57 orded 10, which was a full agonist in Ca(2+)-release assays; its potency and binding affinity for Ins

58 The degree of vesicle release at the fewer, but larger, individual remaining r

59 A binding, inducing opening of the loader to release autoinhibition.

60 pared with a sibling control in EMV size and release based on Nanosight analysis.

61 ar to be good candidates for controlled drug release based wound dressing applications.

62 de) (PLGA) matrix, thereby altering the drug release behavior.

63 eter crater into a continental glacier could release between 8.7 x 10(13) to 5.0 x 10(15) kg of H(2)O

64 aves high-molecular-weight kininogen (HK) to release bradykinin with a catalytic efficiency ~1500-fol

65 Agonist stimulation enhanced PDEV release, but did not alter the average size of EVs compa

66 cells, we found that inhibition of glutamate release by a submaximal concentration of enkephalin was

67 compound (simvastatin) blocked ATP and IL-33 release by lowering the expression of VDAC-1 in the plas

68 provide a mechanistic link to increased ROS release by neutrophils.

69 lly for prolonged periods through controlled release by specifically designed alginate bandages.

70 substrate overcome this barrier and promote release by stepwise exchange of hydrogen bonds.

71 In an ICD process, energy released by electronic relaxation of an excited atom or

72 ted, but have an expansion block that can be released by impairing regulatory T cell associated signa

73 both of its subunits, and this inhibition is released by interaction with H2A-H2B, allowing FACT-H2A-

74 in vivo from which transcription factors are released by mitogen-activated protein kinase (MAPK)-stim

75 In turn, IFN-gamma released by Vdelta2(+) cells upregulates IL-12 secretion

76 ceptors [Ins(1,4,5)P(3)R] and the ability to release Ca(2+) from intracellular stores via type 1 Ins(

77 usters of type-2 ryanodine receptors (RyR2s) release Ca(2+) from the sarcoplasmic reticulum (SR) via

78 ar imaging measures of dopamine synthesis or release capacities, dopamine D(2/3) receptor (D2/3R) or

79 oxidation on CaM's regulation of the calcium release channel, ryanodine receptor (RyR).

80 is related to the mitochondria's ability to release cytochrome c into the cytosol, which triggers th

81 of T(H) 2 cells in the lung, but those cells release decreased T(H) 2 cytokine levels.

82 the conclusion that polarized cholangiocytes release distinct sEV pools to mediate communication via

83 Pharmacokinetic studies of released drugs after intravenous administration showed t

84 of the memory enhancement on glucocorticoid release during the immediate posttraining period.

85 ials contain various additives, which can be released during the entire lifespan of plastics and pose

86 Hyperphosphorylated RB releases E2F transcription factors, activating a transcr

87 ese Ca(2+)-sensitive fraction of spontaneous release events.

88 All modern standards exhibit rapid growth releases every circa 30 years, most likely caused by reg

89 repeat domains of the spectrin tetramers to release excess mechanical stress.

90 ified cohesin ligands, including the cohesin release factor WAPL(2,3).

91 g the stress-sensitive peptide corticotropin-releasing factor (CRF), which has been identified in cri

92 idal MC stimulation and activation in a slow release fashion in the rat.

93 rom the CyNCh (Cysteamine Bitartrate Delayed-Release for the Treatment of NAFLD in Children) clinical

94 ecreted phospholipase A(2) (sPLA(2)) enzymes release free fatty acids, including arachidonic acid, an

95 This study investigated mechanisms of Cr(VI) release from cast iron corrosion scales.

96 Release from chromatin involves opening of the ring at t

97 phosphorylation event prevents condensin II release from chromatin.

98 ulates gonadotropin-releasing hormone (GnRH) release from GnRH neurons to control the reproductive ax

99 em uses a consistent mechanism involving ATP release from ISCs and activation of P2RY1 autoreceptors

100 s synergize with dicarbonyls to induce iCGRP release from isolated skin.

101 We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blu

102 Ca(2+) transients in ICC-SS occurred by release from stores most probably via inositol trisphosp

103 amined 2013 9-10 year olds in the first data release from the Adolescent Brain Cognitive Development

104 picture of the factors influencing the AITC release from the particles is proposed, which describes

105 nds present as soluble forms were completely released from all breads' matrix already at the oral pha

106 account for the rapid transport of sediment released from behind incinerated vegetation, which can f

107 ediated by Scc1-cohesin, which in mitosis is released from chromosomes by Wapl and separase.

108 dogenous neuropeptide cholecystokinin (CCK), released from dentate CCK interneurons, in regulating ne

109 : each night the symbionts catabolize chitin released from hemocytes (phagocytic immune cells) that t

110 ochrome c, a proapoptotic peroxidase that is released from mitochondria during sustained oxidative st

111 e heat shock response, RNA Pol II is rapidly released from pausing at heat shock-induced genes, while

112 on infectious virions of ZIKV when they are released from specific cell types, and enhances virus at

113 0(14) and 2.5 x 10(15) g of black carbon was released from the target and ejected into the atmosphere

114 icant proportion of the total U (20-57%) was released from these three shales after reaction with fra

115 tionally, scaling the relative abundances of released glycan ligands according to their relative abun

116 VH through spinal PAR-2 activation and CGRP release, goats received an injection of 2,4,6-trinitro-b

117 s a pivotal role in such adaptation, and its release has been causally associated with the activity o

118 During this time the released heads remain close to actin and can quickly reb

119 The polarimeter is released here as open hardware, with technical diagrams,

120 rom COVID-19 patients, and their neutrophils released higher levels of NETs.

121 of kisspeptin, which modulates gonadotropin-releasing hormone (GnRH) release from GnRH neurons to co

122 ctivation, and sarcoplasmic reticulum Ca(2+) release (ie, Ca(2+) alternans).

123 hat microglia, not peripheral myeloid cells, release IL-1alpha ex vivo.

124 n signaling increases allergen-induced IL-33 release, ILC2 cytokine production, and airway inflammati

125 r to further viral maturation, assembly, and release, implying additional steps in IB function.

126 CTX-OCT-Alg had a negligible release in 0.1 N HCl, while the CTX-OCT was completely r

127 study their ability to induce CCK and GLP-1 release in enteroendocrine STC-1 cells.

128 in vitro and autophagosome closure and HIV-1 release in human cells.

129 eld experiments have demonstrated ecological release in living populations.

130 Volatility drove the VOC release in SC, and volatility and polarity for IC.

131 e spatial and temporal profiles of NT and NM release in the brain using genetically encoded sensors f

132 estingly, VAChTcKO mice had reduced dopamine release in the dorsomedial striatum but not in the dorso

133 ernalization into endolysosomes, Tat must be released in order for it to activate the HIV-1 LTR promo

134 to be taken up by the target cells and then released in the appropriate cellular compartment to func

135 es to potential large-scale seafloor methane releases in ways that provide insight for future modelli

136 investigate the effect of intra-uterine slow-release insemination (SRI) on pregnancy rates in women w

137 hared to create collagen destruction and Hyp release into both saliva and plasma.

138 cs become rapidly colonized by microbes when released into marine environments.

139 ario, pro-inflammatory factors are intensely released into the bloodstream, causing the so-called "cy

140 age product from this fragmentation event is released into the conditioned medium of cells expressing

141 s show that both substrate translocation and release involve movements of the bulky transport domain

142 Using 3D cell culture, it is shown that drug release is commensurate with cell density, revealing mor

143 gether our data support the model that TFIIB release is important for Pol II to successfully escape t

144 elease, suggesting that aberrant spontaneous release is sufficient to cause disease in humans.

145 he carotenoid does not act as a spring that, releasing its internal strain, induces the dissociation,

146 At steady-state U release, kinetic and spectroscopic results suggest detac

147 rotein remodeling and degradation can occur, releasing large numbers of endogenous peptides.

148 Compounds known to induce MT release like progesterone, ZnSO(4), quercetin, dexametha

149 T cells expressing Hu19-CD828Z released lower levels of cytokines than T cells expressi

150 Thus, the betaAR-mediated modulation of the release machinery and the subsequent increase in the siz

151 ling is under the tight control of glutamate release machinery mediated through vesicular glutamate t

152 ENT G-protein-coupled receptors modulate the release machinery, causing long-lasting changes in synap

153 This release mainly occurs through wastewater since the treat

154 and undergoes monthly structural changes to release mature oocytes.

155 sulation formulation with a microbiota-based release mechanism and show that it facilitates oral deli

156 Notably, the triggered release mechanism of dendrimer-mediated triptolide deliv

157 light, protective measures against fire, and release mechanisms of explosive dispersers.

158 Subsequently, the bubble collapses and releases metastable He[Formula: see text] at the droplet

159 Moreover, chemical releasing methods, such as beta-elimination/Michael addi

160 Ultimately, the combination of controlled release microspheres with a thermoresponsive hydrogel pr

161 Photoactivatable carbon monoxide-releasing molecules (photoCORMs) are chemical agents tha

162 ites and gene bodies suggests that Pol II is released more efficiently into the bodies of beta genes

163 irically-based estimate of on-board and post-release mortality of bycaught marine turtles that has un

164 ating covalent chemistry-mediated EV capture/release, multimarker antibody cocktails, nanostructured

165 mission, when large amounts of glutamate are released, Na(+) accumulated in the terminals, activated

166 hich calls for the development of controlled-release nanoparticle (NP) technologies to further improv

167 lytic replication, underwent cell lysis, and released new virus.

168 Additionally, sustained-release NP-EFs, administered 24 h prior to infection, pr

169 Released O-glycans were purified by an optimized protoco

170 e protection against alpha-toxin through the release of ADAM10 on exosomes-extracellular vesicles of

171 e skin could be independently tuned to allow release of adjuvants and antigen from days up to two wee

172 rotein, EZH2, results in cleavage of B2 RNA, release of B2 RNA from chromatin, and activation of ther

173 Such non-lytic release of beta-coronaviruses results in lysosome deacid

174 BIK1, which is essential for the subsequent release of BIK1 from the FLS2-BAK1 complex and activatio

175 classic oncogenes in tumor development, the release of bioactive amines, and indolent growth of the

176 ticles (CGPU) displayed a GSH-dose dependent release of cisplatin.

177 at compromise mitochondrial function trigger release of DNA damaging reactive oxygen species.

178 eading to concurrent delivery and sequential release of dual cargos toward combinatorial therapy.

179 Both pathways initially involve the release of free arachidonic acid after activation of the

180 ters with calcium transients stimulating the release of gliotransmitters that regulate synaptic and n

181 Applying SSIF to the October 3, 2018 release of GO suggested 1938 unique potentially missing

182 un fiber (EF) composite to provide sustained-release of GRFT, and to examine its safety and efficacy

183 n immune defence which includes a process of release of histones and DNA as neutrophil extracellular

184 ic glial histological signatures and ensuing release of Iba-1 and GFAP into the circulation.

185 Physiological release of IL-17a by these cells was correlated with anx

186 Also, switchable ON/OFF release of insulin is achieved highlighting an autonomou

187 perating as an "artificial pancreas" for the release of insulin.

188 rature diagrams, which was attributed to the release of internal pressure in bulk samples that disint

189 The inflammasome modulates the release of key proinflammatory cytokines associated with

190 egulatory factors that ultimately affect the release of kisspeptin, which modulates gonadotropin-rele

191 ding the drop in myocardial NADH levels, the release of lipofuscin-like pigments, and the increase in

192 Since the initial release of miRPathDB, tremendous progress has been made

193 ing this approach, we detected a significant release of MNPs after 3.5 minutes incubation using just

194 rbent assay to measure levels of spontaneous release of molecules from mast cells in colonic mucosa f

195 The release of most OPEs reached an apparent steady-state wi

196 Day 4 Th17 cells engrafted, induced release of multiple cytokines including IL6, IL17, MCP-1

197 s been thought to be in part mediated by the release of myokines, skeletal muscle-specific cytokines,

198 ly characterized together with the potential release of Na(+) and Ca(2+) cations, revealing suitable

199 ag polyproteins orchestrate the assembly and release of nascent virus particles from the plasma membr

200 The release of national COVID-19 death data by racial/ethnic

201 (2020) show that stress induces the release of noradrenaline from sympathetic nerves, which

202 generates chromosomal abnormalities and the release of nuclear DNA into the cytoplasm, activating th

203 the gene therapy efficacy by prolonging the release of nucleic acid drug payload for sustained, long

204 Capture and release of peptides is often a critical operation in the

205 e the ultra-high loading and high-efficiency release of pH indicators, the ALISA exhibitssatisfactory

206 The release of PHI-base version 4.8 (September 2019) contain

207 As termination is defined by the release of product RNA from the transcription complex, t

208 IgE to these autoallergens, which provoke a release of proinflammatory mediators from skin mast cell

209 gation inhibitors to purportedly inhibit the release of puromycin-labeled nascent peptides from ribos

210 Human release of reactive nitrogen (N) to the environment has

211 circumstances of the undeclared 2017 nuclear release of ruthenium that led to widespread detections o

212 eins upon flattening of caveolae could allow release of specific lipids into the bulk PM.

213 The sequential dissolution and autonomous release of the chemoattractant and killing agents result

214 in the circulation time of the conjugate and release of the drug for full activity at the target site

215 sphorylating the adaptor ACT1 leading to the release of the essential ubiquitin ligase TRAF6 from the

216 (S2'), cleavage of which is required for the release of the fusion peptide(11,12).

217 ion is followed by subsequent dithiothreitol release of the isolated EVs for downstream functional an

218 BAT (+BAT) improves cardiac function via the release of the lipokine 12,13-diHOME.

219 ntrolled by polymer degradation and involves release of the remaining drug.

220 ylate derivatives, initiating the downstream release of the small molecule drug by a retro DA reactio

221 The release of these granules is dependent on intracellular

222 gastrointestinal passage and controlling the release of these therapeutic cells across the intestinal

223 ine glioblastoma models and thus enhance the release of tumor-specific biomarkers into the bloodstrea

224 lled chemical or electrochemical capture and release of UO(2)(2+) in monophasic (organic) or biphasic

225 levels (which has been linked to nonosmotic release of vasopressin) was assessed.

226 shown that heparanase (HPSE) facilitates the release of viral particles by cleaving HS.

227 l-mediated lung metastasis via the sustained release of Zileuton.

228 s shown to be applicable to other accidental releases of radionuclides.

229 a terminalis AT1aR neurons induced glutamate release onto magnocellular neurons and was sufficient to

230 Our code is released open source and freely available to the scienti

231 Ecological release, originally conceived as niche expansion followi

232 During herbivory, marine diatom species release oxylipins that impair grazer reproduction and se

233 eceptor availability (P = 0.02) and dopamine release (P = 0.05) also predicted improvements in clinic

234 CLM displayed a drug release pattern in response to pH/enzyme dual stimuli an

235 Peptides such as gastrin-releasing peptide receptors targeting radiopharmaceutica

236 We found that both AtPTPN and ZmPTPN release Pi by hydrolyzing GDP/GMP/dGMP/IMP/dIMP, and tha

237 Actin-membrane release plays a similar role in protrusions driven by in

238 2/3 receptor availability and lower dopamine release predicting greater improvements.

239 This is accompanied by an increase in OSN release probability and a reduction in GABA(B) receptor

240 LbL composition and architecture, component release profiles in the skin could be independently tune

241 burst release and optimal modulation of the release profiles limit their clinical use.

242 atum can trigger dopamine signals, but their release properties are not well understood.

243 ons for instant products with improved aroma release properties.

244 on profiles of several commercial controlled-release proton pump inhibitors in simulated stomach and

245 The release rate of (177)Lu (or labeled metabolites) from tu

246 The ATP-triggered half-site release rate of KIF1A was similar to the stepping rate,

247 om this family are able to undergo click-and-release reactions, finding interesting applications in c

248 are responsible for the pathological calcium release, regarding the tissue origin of the arrhythmic b

249 tributes to airway inflammation and cytokine release remain ambiguous.

250 7 does not mediate the residual asynchronous release remaining in the absence of SYT1.

251 apillary cells control pollen germination by releasing resources only to compatible pollen thereby al

252 ement and survivorship immediately following release, retained survivorship benefits during 1 and 6 m

253 P1 directly exploits the tendency of UPF1 to release RNA upon ATP binding and hydrolysis.

254 oading as a function of the level of vesicle release.SIGNIFICANCE STATEMENT Auditory information is e

255 The spatial features of release sites and MVR events are similarly tightened by

256 eurotransmitter receptors facing presynaptic release sites is a fundamental determinant of their coac

257 in coupling presynaptic calcium channels to release sites.

258 ynthetic membranes, while mitogenic cues are released slowly from the microrods.

259 GSH-triggered MnO degradation simultaneously released smaller Au NPs as numerous cavitation nucleatio

260 w that apoptotic lymphocytes and macrophages release specific metabolites, while retaining their memb

261 bound RNApII molecules sometimes binding and releasing Spt4/5 multiple times.

262 d that chicken BST-2 blocks the virus at the release stage.

263 We conclude that, as in model A, the Pi release step is before the first tension-generating step

264 d skin bacterial diversity and stimulated to release stored antimicrobial peptides (AMPs).

265 sufficient to induce intracellular protease release, suggesting altered membrane integrity after the

266 -potential-independent spontaneous glutamate release, suggesting plumes are a consequence of ineffici

267 spontaneous release without altering evoked release, suggesting that aberrant spontaneous release is

268 nto the microbial food web, whereas cleavage releases sulfur into the atmosphere.

269 ase, a recently identified mediator of HSV-1 release, syndecan-1 has not been previously investigated

270 Cytokine release syndrome (CRS) is a life-threatening treatment-r

271 or severe adverse events, including cytokine release syndrome (CRS).

272 rotumor effects and its role in the cytokine release syndrome.

273 is following work in polymer-controlled drug releasing systems.

274 Syt1/Syt7 double mutants displayed more release than Syt1 mutants alone, indicating SYT7 does no

275 ll-cycle transition and profiles of cytokine release that resembled those of normal memory T cells.

276 slocations above a critical strain energy to release the accumulated strain energy as the film thickn

277 n their metastable Z isomer liquid phase and release the energy by optically triggered crystallizatio

278 RARRES1, which is proteolytically cleaved to release the extracellular domain, was endocytosed by pod

279 nge would result in deprotonation of Glu8 to release the hormone peptide from the amyloid.

280 ly photosensitive RGCs (ipRGCs) in mice that release the inhibitory neurotransmitter gamma-aminobutyr

281 The in vitro digestion released the antioxidative compounds, leading to higher

282 ete maturation of VI, and is responsible for releasing the lytic protein from the hexon cavity during

283 structural integrity, and eventually burst, releasing their contents into the extracellular matrix.

284 hrough the primary interface and that Ca(2+) releases this interaction, inducing PIP(2)/membrane bind

285 activation antagonizes CRF-mediated hormone release, this storage/resurfacing mechanism may allow fo

286 t, and this is mediated in part by astrocyte-released thrombospondins (TSPs) and activation of their

287 inery, and facilitating RNA polymerase pause-release to regulate gene expression.

288 ing under acidic conditions in the Golgi and release under conditions of higher pH in the ER.

289 It allows studying VOCs release upon reconstitution and supports the development

290 n for modulators of hypotonicity-induced ATP release using HEK-293 cells and murine cerebellar granul

291 and the cellular process of neurotransmitter release via exocytosis and provide a better physical fra

292 n surface, where the duration of transmitter release was quantified and correlated to the vesicle siz

293 However, with CsChrimson, dopamine release was significantly higher in the heel than the me

294 n bursts has been associated to neuropeptide release, we hypothesized that I(h) would be important fo

295 cancer cell invasion, and vesicular content release, we sought to elucidate the signaling pathway do

296 apid micellar breakdown and concomitant drug release, when in breast cancer cells with increased leve

297 d levels were increased 2 weeks after tendon release, when the levels of high-energy phosphates and g

298 ion diminishes sarcoplasmic reticulum Ca(2+) release, which, in turn, reduces diastolic cytosolic Ca(

299 ough microfluidic channels, trigger contents release with spatial and temporal control.

300 a single mutation that augments spontaneous release without altering evoked release, suggesting that