ライフサイエンスコーパス: release of

1 3-hydroxyisobutyryl-CoA hydrolase decreases release of 3-HIB and lipid accumulation in both cell typ

2 d release between 24-120 h with a cumulative release of 40.6 % and a 670-fold increase in photoacoust

3 s a positive DeltaV( ) of activation and the release of 78 +/- 4 water molecules.

4 e transcription factor NRF2, facilitates the release of a nuclear cytokine, interleukin-33 (IL-33).

5 (PPO)-PEO poloxamers, capable of controlled release of a therapeutic recombinant adeno-associated vi

6 that following APP processing, extracellular release of Abetaos mediates the propagation of the synap

7 across density surfaces, thus enhancing the release of accumulated CO(2) to the atmosphere.

8 the C4 position, which improved delta(u) for release of acetate up to 7-fold, while retaining all the

9 acetylcholine receptors (nAChRs) by quantal release of acetylcholine (ACh) from motoneurons is suffi

10 asal forebrain neurons may trigger increased release of ACh onto auditory neurons in primary auditory

11 ood industry, enabling a controlled and slow release of active antimicrobial agents, such as essentia

12 in is protected from proteolysis, preventing release of active toxin.

13 e protection against alpha-toxin through the release of ADAM10 on exosomes-extracellular vesicles of

14 de and PVA showed a sustained and controlled release of Ade and facilitated the osteogenic differenti

15 e skin could be independently tuned to allow release of adjuvants and antigen from days up to two wee

16 The prion model predicts the release of aggregates from a first-order cell and subseq

17 and this process is further triggered by the release of angiogenic factors.

18 bearing large established tumours, the burst release of annexin A5 owing to diselenide-bond cleavage

19 for the lack of action in the mitigation of release of antibiotics into the aquatic environment.

20 -covalent methods of binding, retention, and release of antibody-based therapeutics in the vitreous.

21 ytokines and histamine did not stimulate the release of any cytokines.

22 The OSA-based system offered the fastest release of AP and, consequently, had the best initial an

23 is initiated by phospholipase A(2)-mediated release of arachidonic acid, followed by its enzymatic o

24 Remarkably, zero-order release of atenolol was achieved from FAU (SiO(2):Al(2)O

25 hat Abeta40 bound to GPVI, which induced the release of ATP and fibrinogen, resulting in platelet agg

26 nal tail is cleaved by caspase, allowing the release of ATP through the main pore.

27 Release of ATP to the extracellular compartment and subs

28 and modulate baroreflex sensitivity via the release of ATP.

29 Here, we report that the release of autophagosome precursors from recycling endos

30 We propose that the release of axial respiratory constraints, combined with

31 rotein, EZH2, results in cleavage of B2 RNA, release of B2 RNA from chromatin, and activation of ther

32 of cholecystokinin to mice resulted in acute release of BAs into the intestinal lumen and increased p

33 Elemental budgets indicate substantial release of base cations important for inorganic carbon r

34 Such non-lytic release of beta-coronaviruses results in lysosome deacid

35 nduced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and ac

36 BIK1, which is essential for the subsequent release of BIK1 from the FLS2-BAK1 complex and activatio

37 n United States and northern Mexico included releases of billions of sterile pink bollworm moths from

38 ctene (TCO) is a powerful way to control the release of bioactive agents and imaging probes.

39 classic oncogenes in tumor development, the release of bioactive amines, and indolent growth of the

40 intestinal fluid (fed state) facilitated the release of bioactive compounds to gastrointestinal fluid

41 cause of adverse effects associated with the release of bioactive compounds, including toxic cyanopep

42 ion, and PEAD-base Coa exhibited a sustained release of bioactive IGF-1 over 3 weeks.

43 of erosion as a key driving force behind the release of bioactive molecules from supramolecular gels,

44 to favor osteoclast differentiation and the release of bioactive osteocalcin in the general circulat

45 nctionality was also examined in loading and releasing of biotinylated peptides from streptavidin bea

46 Both phenomena could be attributed to the release of bounded phenolic compounds after applying HPP

47 , mechanisms of HSA nanoparticle loading and release of BTZ compounds were demonstrated, enhanced ant

48 (2+) signals, which are sustained by diffuse release of Ca(2+) through a functionally distinct proces

49 nuclear calcium responses were amplified by release of calcium from ryanodine-sensitive intracellula

50 Controlled release of CAR from PLA nanoparticles (NPs) could improv

51 the efficient intracellular delivery and the release of Cas9 RNP into 293T cells and colorectal cance

52 BB CAR-T cells or SHP1 to tune down cytokine release of CD28 CAR-T cells.

53 The untimely release of Cdc14 from the nucleolus upon activation of H

54 the progression of mitosis and ensures that release of Cdc14 phosphatase occurs only after completio

55 on and ebullition and 2.6-3.3 Tg from spring release of CH(4) stored in bubbles in winter lake ice.

56 chelation of extracellular calcium leads to release of chelation-induced exosomes (CI-exosomes) from

57 regulates cholesterol: Dispatched1 controls release of cholesterylated SHH, and Patched1 antagonizes

58 ticles (CGPU) displayed a GSH-dose dependent release of cisplatin.

59 lighting a role for the non-photorespiratory release of CO(2) in heat tolerance.

60 obilizes Mn and P and that this leads to the release of colloidal P and iron (Fe).

61 The release of complement C1q from macrophages in the inflam

62 monitoring of the electrochemical uptake and release of copper ions from natural seawater.

63 We investigated the release of cTns and copeptin in the first hours after ex

64 ance of gastric digestion in influencing the release of curcumin during gastrointestinal digestion.

65 eroxidase activity ultimately results in the release of cyt c into the cytosol for the engagement of

66 azole exhibited diminished degranulation and release of cytokines and histamine in response to allerg

67 3SS and effectors induced the production and release of cytotoxic amyloids from lung endothelium, inc

68 , the molecular hallmark of ICD features the release of damage-associated molecular patterns (DAMPs)

69 onRI complex activates these cells, inducing release of disease-causing mediators, cytokines, and enz

70 at compromise mitochondrial function trigger release of DNA damaging reactive oxygen species.

71 as synchronous firing of ChINs induces local release of dopamine.

72 r Pgp inhibitor, effect of the inhibitors on release of Dox from implants in PBS, in vivo Dox distrib

73 )-responsive diselenide bonds for controlled release of doxorubicin (DOX) at tumor sites are develope

74 further exploited to trigger the controlled release of droplet components.

75 lly, successful treatments require sustained release of drug payloads to maintain the effective thera

76 model with thermodynamically non-spontaneous release of drug.

77 cess and can be used for the time-controlled release of drugs in postoperative therapy.

78 eading to concurrent delivery and sequential release of dual cargos toward combinatorial therapy.

79 For example, the release of elemental silicon, phosphorus (P(4)), and sul

80 transition also enables thermally triggered release of embedded drugs for anti-inflammatory treatmen

81 d properties on its deformation and possible release of emboli under different hemodynamic conditions

82 diotherapy used prior to alloSCT induces the release of endogenous alarmins (eg, HMGB-1, ATP, IL-1alp

83 ST-2 is an antiviral protein that blocks the release of enveloped viral particles by linking them to

84 Both PLGA and PPS MPs enabled sustained release of EPO-R76E, providing therapeutic benefits incl

85 nsient electrical stimulus that promotes the release of exosomes carrying transcribed mRNAs and targe

86 e in response to infection, facilitating the release of exosomes that serve as decoys for bacterially

87 Release of extracellular vesicles (EVs) is a common feat

88 ctive defluorination was demonstrated by the release of F(-) and the formation of the corresponding p

89 ered that ssRNA phage infection triggers the release of F-pili from host cells, and that higher multi

90 emethylation by ALKBH5 versus FTO results in release of FA, an endogenous one-carbon unit but potenti

91 digestibility was observed through increased release of FAAs and appearance of small protein fragment

92 Conversely, impaired release of FFAs and other lipid mediators can also disru

93 derly as well as their individual retronasal release of five aroma compounds (2-pentanone, 2-nonanone

94 d in the degradation of storage proteins and release of flavour precursors.

95 Both pathways initially involve the release of free arachidonic acid after activation of the

96 which astrocytes modulate homeostasis is the release of functional mitochondria (Mt) that are taken u

97 d further highlight the importance of the co-release of GABA and glutamate from immature glycinergic

98 lamic population that may signal through the release of GABA and/or dopamine.

99 We have investigated the release of gases and volatile organic compounds (VOCs) f

100 ithin 6 to 10 generations following a single release of gene-drive males.

101 Small cage trials show that single releases of gene-drive males robustly result in efficien

102 For the latest release of Genome3D (v2.1), the underlying dataset of se

103 ters with calcium transients stimulating the release of gliotransmitters that regulate synaptic and n

104 Release of glutamate from nanoclusters in vivo caused en

105 Applying SSIF to the October 3, 2018 release of GO suggested 1938 unique potentially missing

106 ed high GRFT loading, and provided sustained-release of GRFT for up to 90 d.

107 un fiber (EF) composite to provide sustained-release of GRFT, and to examine its safety and efficacy

108 In conchocelis, the release of HCO(3)(-) from shell promoted by carbonic anh

109 filed at different time points following the release of HeLa cells from G1/S phase.

110 ned the effect of ZIKV NS1 on expression and release of heparan sulfate (HS), hyaluronic acid (HA), a

111 n immune defence which includes a process of release of histones and DNA as neutrophil extracellular

112 XE and MXE action, we assayed the sequential release of HTG products from cell walls pre-labeled with

113 Micronization increased the release of hydroxytyrosol, oleuropein, caffeic acid, and

114 ic glial histological signatures and ensuing release of Iba-1 and GFAP into the circulation.

115 cleotide alleviated human monocyte-dependent release of IL-1 and IL-6 in a xenotransplanted B-cell ly

116 Physiological release of IL-17a by these cells was correlated with anx

117 disease severity, implicating GSDMD-mediated release of IL-1beta sEVs in the pathogenesis of intestin

118 While GSDMD-dependent release of IL-1beta-containing sEVs is detected in cultu

119 nt of the innate immune system that leads to release of IL-1beta.

120 ed by activated caspases associated with the release of IL-1beta.

121 eoxyglucose and metformin, also promoted the release of IL-6 and IL-8.

122 resulted in improved loading, targeting, and release of immunomodulatory agents.

123 d macrophages (TAM) that inhibit T cells via release of immunosuppressive cytokines and engagement of

124 gnalling through effects on gene expression, release of immunosuppressive cytokines and epithelial pl

125 The cooking methods differently affected the release of individual phenolic compounds.

126 hin films facilitated sustained and temporal release of individual vaccine components from polymer mu

127 VAMP3 is essential for viral trafficking and release of infectious progeny, in various HCMV strains a

128 The release of infectious virions requires the production of

129 a suggest that CTB EVs enhance decidual cell release of inflammatory cytokines, which we theorize is

130 practically prohibited, the dose-controlled release of insulin in the entire diabetic range is demon

131 Also, switchable ON/OFF release of insulin is achieved highlighting an autonomou

132 While at normal glucose levels, the release of insulin is practically prohibited, the dose-c

133 ter, pH-responsive hydrogel layer and to the release of insulin.

134 ed insulin and polymers, promoting the rapid release of insulin.

135 perating as an "artificial pancreas" for the release of insulin.

136 rature diagrams, which was attributed to the release of internal pressure in bulk samples that disint

137 This platform enables the controlled release of intra-lymph-mobile small-molecular cargo, whi

138 expression resulted in the accumulation and release of intracellular TRIM21 (one component of SSA),

139 The results were compared with the cytokine release of isolated peripheral T cells in a subset of th

140 The inflammasome modulates the release of key proinflammatory cytokines associated with

141 egulatory factors that ultimately affect the release of kisspeptin, which modulates gonadotropin-rele

142 es to coordinate subunit joining through the release of late-stage mtLSU assembly factors.

143 ding the drop in myocardial NADH levels, the release of lipofuscin-like pigments, and the increase in

144 Furthermore, the triggered release of loaded liposomes and reuptake by target macro

145 chronic myeloid leukemia (CML) triggers the release of LSCs from the BM into the circulation and imp

146 agellin initiates pyroptosis and concomitant release of lysophospholipids which in turn enhance expre

147 Here, we present a new release of MatrisomeDB, a searchable collection of curat

148 Caspase-1 activation mediated release of mature IL-1beta and IL-18 in response to cano

149 e activation of Caspase-1 and the subsequent release of mature interleukin-1beta and interleukin-18.

150 Increased storage and release of mechanical energy may explain the enhanced ba

151 In this study the thermal release of metals from three nanomaterials, namely CuO,

152 and genetic tools indicates that the optimal release of microvesicles is dependent upon the PAF recep

153 Since the initial release of miRPathDB, tremendous progress has been made

154 Recent studies showed that the release of misfolded alphaSN from human and rodent neuro

155 ntrinsic apoptosis pathway, triggered by the release of mitochondrial intermembrane space proteins in

156 ing this approach, we detected a significant release of MNPs after 3.5 minutes incubation using just

157 Release of molecular danger signals from injured cell mi

158 rbent assay to measure levels of spontaneous release of molecules from mast cells in colonic mucosa f

159 The release of most OPEs reached an apparent steady-state wi

160 IF2alpha), the SG assembly G3BP paralogs, or release of mRNAs from ribosomes via translation elongati

161 Day 4 Th17 cells engrafted, induced release of multiple cytokines including IL6, IL17, MCP-1

162 s been thought to be in part mediated by the release of myokines, skeletal muscle-specific cytokines,

163 ly characterized together with the potential release of Na(+) and Ca(2+) cations, revealing suitable

164 Microparticle delivery and release of NAMPT inhibitor at the tumor site offers a sa

165 ag polyproteins orchestrate the assembly and release of nascent virus particles from the plasma membr

166 The release of national COVID-19 death data by racial/ethnic

167 NET-mediated bacterial capture, reduces the release of NDPs, and improves outcome in murine models o

168 at viable SARS-CoV-2 can directly induce the release of NETs by healthy neutrophils.

169 Airway fluid was analyzed for the release of NETs by myeloperoxidase-DNA complexes using a

170 uce larger swarms against Candida, but their release of NETs is delayed, resulting in impaired contro

171 Release of neuropeptides requires long-lasting, high lev

172 Calcium (Ca(2+))-evoked release of neurotransmitters from synaptic vesicles requ

173 We verified the sustained release of neurotrophin-3 from peptide-conjugated PEG hy

174 through Toll-like receptor 9 (TLR9)-mediated release of neutrophil elastase and proteinase 3 and subs

175 ginally described in humans, that blocks the release of newly formed virus particles from infected ce

176 (2020) show that stress induces the release of noradrenaline from sympathetic nerves, which

177 gy-transfer (FRET) method to investigate the release of novel high-drug-loading (50 wt %) nanoparticl

178 generates chromosomal abnormalities and the release of nuclear DNA into the cytoplasm, activating th

179 the gene therapy efficacy by prolonging the release of nucleic acid drug payload for sustained, long

180 ycin could improve persistent function after release of obstruction (de-obstruction or REL).

181 One day prior to release of obstruction (preREL), voiding parameters and

182 stent tissue pathology and dysfunction after release of obstruction is often deemed irreversible with

183 urced from melting of glacial ice and direct release of occluded CO(2) gases into the water column.

184 The controlled release of odontogenic exosomes resulted in a reparative

185 le catalytic framework to achieve controlled release of one of the most important chemotherapy drugs

186 um showed that mucosal hydration reduced the release of only two compounds, pentan-2-one and linalool

187 d delivery of stem cells with the controlled release of osteogenic factors, within a mechanically-str

188 id not significantly impact the net cerebral release of oxidative and inflammatory markers.

189 ance antibacterial activities, including the release of oxygen radicals.

190 tal cycle that culminates in the synchronous release of parasites from red blood cells, which trigger

191 ium column of glass beads to assess: (i) the release of particulate plastic from the sludge, and (ii)

192 sulate nucleic acid cargo, exhibit sustained release of payload, and can stably transfect cells.

193 hydrogen bonds are cleaved, resulting in the release of pemetrexed.

194 Capture and release of peptides is often a critical operation in the

195 Historical releases of PFOA and related epidemiological work in thi

196 e the ultra-high loading and high-efficiency release of pH indicators, the ALISA exhibitssatisfactory

197 involved in the replication, packaging, and release of phage particles have been preferentially lost

198 At the optimum point, the in-vitro release of phenolic compounds in simulated gastric and i

199 The release of PHI-base version 4.8 (September 2019) contain

200 ppress decomposition of new litter C inputs, release of physicochemically protected C due to iron (Fe

201 A massive release of platelet-derived MVs occurs during HIV infect

202 at membrane budding results in the sustained release of platelets directly into the peripheral circul

203 to require several rounds of binding to and release of polypeptide substrates at the substrate-bindi

204 Optional extensions, including the release of primary human cells or the design of the pape

205 inflammatory M1-like microglia and increased release of pro-inflammatory cytokines.

206 on of NF-kappaB to promote the extracellular release of pro-inflammatory mediators.

207 As termination is defined by the release of product RNA from the transcription complex, t

208 t/phage ratio becomes more favorable for the release of progeny.

209 epair that contain stem cells and controlled-release of programming factors is innovative, and will f

210 inds to murine immune cells and inhibits the release of proinflammatory cytokines that cause the neur

211 IgE to these autoallergens, which provoke a release of proinflammatory mediators from skin mast cell

212 Efficient release of promoter-proximally paused RNA Pol II into pr

213 gation inhibitors to purportedly inhibit the release of puromycin-labeled nascent peptides from ribos

214 Release of Rad-mediated inhibition of Ca(2+) channel act

215 s shown to be applicable to other accidental releases of radionuclides.

216 Human release of reactive nitrogen (N) to the environment has

217 This is ascribed to the well-known release of reactive oxygen at higher states-of-charge, i

218 of the prevalence of infection following the release of restrictions could inform post-lockdown pande

219 circumstances of the undeclared 2017 nuclear release of ruthenium that led to widespread detections o

220 Rab family of GTPases that allows controlled release of secretory granules.

221 the uroepithelium, where it may regulate the release of sensory mediators such as ATP, which in turn

222 were quantitatively analyzed to estimate the release of seven common plastics.

223 F-actin at the plasma membrane and increased release of sEVs, with altered content.

224 hypothesis of connexin hemichannel-mediated release of signaling molecules by astrocytes having an e

225 A general platform for selective release of small-molecule cargoes in beta-cells over oth

226 evidence that hyperinsulinemia promotes the release of soluble pro-inflammatory mediators from macro

227 eins upon flattening of caveolae could allow release of specific lipids into the bulk PM.

228 pontaneous Ca(2+) signals resulting from the release of SR Ca(2+) through RyR2s ("Ca(2+) sparks") and

229 BODIPY photocages allow the release of substrates using visible light irradiation.

230 is perspective, the localization and gradual release of such a potent immunotherapeutic agent in the

231 d on LRA prodrugs, designed for controllable release of the active LRA after a single injection.

232 pyroptosis, inflammasomes can also drive the release of the alarmin IL-1alpha.

233 The release of the American Heart Association's 2030 Impact

234 Release of the anterior and peroneal compartments was su

235 than with chaperones alone, in line with the release of the chaperones in the bacterial cytoplasm aft

236 The sequential dissolution and autonomous release of the chemoattractant and killing agents result

237 ial intratumoral concentration and sustained release of the chemotherapeutic.

238 mopolymer depots showed that degradation and release of the depot coincided with the sustained TAF re

239 This leads to a mechanism in which the release of the disordered NTR from a binding groove on t

240 in the circulation time of the conjugate and release of the drug for full activity at the target site

241 nges depends on enhanced autocrine/paracrine release of the EGFR ligand transforming growth factor al

242 sphorylating the adaptor ACT1 leading to the release of the essential ubiquitin ligase TRAF6 from the

243 s specific conformational changes leading to release of the flexible N-terminus from the docking inte

244 (S2'), cleavage of which is required for the release of the fusion peptide(11,12).

245 One step in disassembly is the release of the general transcription factor TFIIB, altho

246 persists through the transition state until release of the hydrolysis product, despite changes in ri

247 ) inflammasome to trigger the maturation and release of the inflammatory cytokine interleukin-1beta (

248 ion is followed by subsequent dithiothreitol release of the isolated EVs for downstream functional an

249 BAT (+BAT) improves cardiac function via the release of the lipokine 12,13-diHOME.

250 It has been just over a decade since the release of the maize (Zea mays) Nested Association Mappi

251 activated caspase-1 resulted in the cellular release of the mature cytokines IL-1beta and IL-18 and i

252 se abnormalities were attributed to aberrant release of the microtubule organizing center (MTOC) link

253 complexes to the inclusions is suggested by release of the mRNA by puromycin, a peptide chain termin

254 lowing confirmation of nanocluster delivery, release of the nanocluster payload into brain tissue can

255 e issues are thought to arise from increased release of the neurotransmitter GABA.

256 We also report a new release of the PRIDE database with an improved technical

257 in a dose-dependent manner and decrease the release of the proinflammatory cytokine, IFN-gamma.

258 rigger conformational changes for the timely release of the promoter DNA to commence the transition i

259 ntrolled by polymer degradation and involves release of the remaining drug.

260 ylate derivatives, initiating the downstream release of the small molecule drug by a retro DA reactio

261 s correct plug processing and slows down the release of the steroid hormone 20E from the mating plug.

262 y transfer into the protein by impairing the release of the strain energy.

263 e, increase storage duration and control the release of the therapeutic ranges of free radicals requi

264 Ca(2+)-ATPase pump inhibitors, and only the release of the Thg-sensitive Ca(2+) store induces Ca(2+)

265 Thus, PKA binding promotes release of the unphosphorylated R domain from its inhibi

266 e amounts of polyP, and upon cell lysis, the release of the vacuolar polyP could nonphysiologically c

267 ssory protein viral protein U (Vpu) enhances release of the virus from host cells by down-regulating

268 f polymer-DNA complexes (polyplexes) and the release of their cargo.

269 telets can directly kill C. albicans through release of their granular contents.

270 The interaction induced platelet spreading, release of their granule content, and the generation of

271 The release of their less toxic decomposition products into

272 The release of these granules is dependent on intracellular

273 gastrointestinal passage and controlling the release of these therapeutic cells across the intestinal

274 only important for better understanding the release of this specific drug from vesicular phospholipi

275 ts, induced expression of TNF-alpha mRNA and release of TNF-alpha protein in ovarian cancer cells.

276 ontinuous AC(50) data from the February 2019 release of ToxCast/Tox21.

277 exposed persons is a priority following the release of toxic chemicals.

278 chondrial damage is often accompanied by the release of toxic proteins such as cytochrome c.

279 Higher release of trans-cinnamaldehyde enhanced bread crystalli

280 The release of trans-Res from GSP was ~ 45% during gastric d

281 e recommend that reserves designated for the release of translocated pandas receive priority consider

282 of the blood-brain barrier (BBB) hinders the release of tumor biomarkers.

283 ine glioblastoma models and thus enhance the release of tumor-specific biomarkers into the bloodstrea

284 ates (muPLs) were realized for the sustained release of two anti-inflammatory molecules, the natural

285 Endogenous release of type I IFNs with the double-stranded RNA mime

286 ansfer reactions that are accompanied by the release of undecaprenyl pyrophosphate, solanesyl pyropho

287 AFFF use leads to environmental releases of unknown per- and polyfluoroalkyl substances

288 lled chemical or electrochemical capture and release of UO(2)(2+) in monophasic (organic) or biphasic

289 Among recent updates are the release of variation calls from 1000 Genomes Project dat

290 levels (which has been linked to nonosmotic release of vasopressin) was assessed.

291 eventual rupture of mast cells, resulting in release of viable S aureus into the extracellular space.

292 shown that heparanase (HPSE) facilitates the release of viral particles by cleaving HS.

293 and glial activation that, together with the release of viral proteins, trigger a pathogenic cascade

294 es, and that TFEB activation facilitates the release of virions in extracellular vesicles via secreto

295 loping a delivery vehicle for the controlled release of vitamin B6 over a prolonged period of observa

296 noid accumulation pattern, but also with the release of volatile apocarotenoids that presumably serve

297 es essential for energy-efficient uptake and release of water.

298 that peripheral Wnt3a signaling triggers the release of Wnt5a in the spinal cord, and inhibition of s

299 mercial endoxylanase on wheat bran; a steady release of xylose monosaccharide was observed.

300 l-mediated lung metastasis via the sustained release of Zileuton.