ライフサイエンスコーパス: relevant

1 on of SARS-CoV-2 RdRp by RDV is biologically relevant.

2 ologist, while in the expert its use is less relevant.

3 er toxic purine intermediates, could be more relevant.

4 humans select predictors that might be most relevant.

5 pic acid esters, while concentration was not relevant.

6 haracterize the effects of a physiologically relevant (2 mM) Ca(2+) concentration on zwitterionic pho

7 three experiments using word stimuli, domain-relevant and atypical conceptual access for the categori

8 al response of 131 A. oculatus males towards relevant and controlled conspecific versus heterospecifi

9 to train striatal projection neurons to gate relevant and suppress distracting cortical inputs.

10 Thus, timely, rigorous, relevant, and ethical clinical research is needed to imp

11 efficacy data, due primarily to a paucity of relevant animal models of penile HIV infection.

12 Here, we show that clinically relevant antagonists used for treating autoimmune condit

13 We reasoned that clinically relevant antifungal resistance could derive from transcr

14 were revealed as a source of compounds with relevant antioxidant and anticancer activity.

15 Aromatic amines are relevant aquatic organic contaminants whose photochemica

16 ect investigations into neuropsychologically-relevant architectural modifications across systematic r

17 CDK4/6 activity is clinically relevant as mutations, deletions, and amplifications tha

18 This was functionally relevant, as deletion of RUNX1 in ccRCC cell lines reduc

19 Another relevant aspect in intratumor heterogeneity is cell plas

20 our indeed constrains models to behaviorally relevant aspects of the environment, but that this appro

21 st function in biomedically and industrially relevant bacteria and achieved target- and species-speci

22 suggest that these subtypes are biologically relevant because they appear to have distinct genetic ar

23 oduced alterations in a constellation of ASD-relevant behaviors.

24 umber of combinations demonstrate clinically relevant benefits, which remain concentrated in patients

25 must be applied with an understanding of the relevant biological and computational theories.

26 ed as a brain region that integrates feeding-relevant biological signals with learning and memory pro

27 s tear MUC5AC mucin can be used as a disease-relevant biomarker for conjunctiva GC health.

28 t only revealed correlated expression of the relevant biosynthetic genes with carotenoid accumulation

29 seen between high aFXa and 90-day clinically relevant bleeding (4.8% vs. 2.9%, p = 0.34) or major ble

30 able compounds against a panel of clinically relevant BLs: class A CTX-M-15 and KPC-2, subclass B1 ND

31 Herein, we used the biologically relevant calcium ion to investigate the conformation of

32 ir protein-level responses to two clinically relevant cancer drugs.

33 pathology-proven data to guide treatment in relevant cases.

34 to flexibly assign sounds into behaviorally relevant categories.

35 ing to its understanding of the task and its relevant causal variables.

36 Two relevant CB7 effects are proposed, a base-catalyst media

37 y mapping framework to more diverse, disease-relevant cell types and states.

38 designed to selectively edit therapeutically relevant cell types including epithelial cells, endothel

39 kers and features as well as therapeutically relevant cell types, cell states, and cellular interacti

40 s us to identify causative genetic variants, relevant cell types/states, target genes, and mechanisms

41 therefore went on to test if therapeutically relevant changes in temperature could influence micellar

42 served to deform at binding to HTR: while no relevant changes were observed in the hydrodynamic sizes

43 However, the relevant characteristics of such an effort have been unc

44 Expert-level models for detecting clinically relevant chest radiograph findings were developed for th

45 ght the importance of genetic testing in the relevant clinical context of electrophysiological findin

46 After adjusting for disease severity and relevant clinical factors, even small amounts of myocard

47 inear range of this device did not match the relevant clinical range for glucose in blood.

48 neal puncture injuries as seen in a military relevant clinical setting and a realistic approach for a

49 ted to be capable of preserving biologically relevant complexes into the gas phase as multiply charge

50 scovery in flow to generate pharmaceutically relevant compound libraries.

51 l building blocks on the way to biologically-relevant compounds.

52 This inhibition occurs at clinically relevant concentrations and may contribute to bupropion'

53 enzymatic transformation of environmentally relevant concentrations of a diverse range of chemical c

54 Exposure to environmentally relevant concentrations of oil could impact survival of

55 L) and over a broad range of physiologically relevant concentrations.

56 n tissue injury induced under pathologically relevant conditions is poorly understood.

57 Under physiologically relevant conditions of lower force (0.3 pN) and lower sa

58 is were dysregulated more in physiologically relevant conditions treated with AZM, likely due to gene

59 g of adsorbed PS films under physiologically relevant conditions using a novel, to our knowledge, exp

60 virus-glycan interactions in physiologically relevant conditions.

61 e of testing compounds under physiologically relevant conditions.

62 al ensembles from simulations, even when the relevant conformations are rarely observed.

63 ystem dynamically recalls memories to detect relevant cues in complex sensory scenes.

64 of macrophages with upregulation of immunity relevant cytokine and co-stimulatory markers.

65 Galactomannan and relevant cytokine levels were assessed in serum, plasma

66 during acute infection, including additional relevant data from non-human primate (NHP) studies.

67 ST solution for rapidly providing clinically relevant data to manage complex DR-TB cases.

68 Relevant data was extracted and synthesized for narrativ

69 aunal populations to recover to functionally relevant densities.

70 es were the risk of depression or clinically relevant depressive symptoms (total of incident and recu

71 icity over Time analyses provided clinically relevant descriptions of neutropenia and fatigue traject

72 a and provided an optimized, physiologically relevant detection limit of 1.0 nM.

73 the diversity and distribution of clinically relevant determinants of pathogenicity and antimicrobial

74 bility 99.4% vs 78.8%), whereas there was no relevant difference between the beginning and end of 8 h

75 In nurses, a relevant difference was found between the beginning and

76 These behaviorally relevant differences in local and between-region synchro

77 s often related to the breakdown of the last relevant directed catalytic cycle within a dynamical sys

78 epigenetic alterations in schizophrenia and relevant disease models and discuss their putative origi

79 , short-duration treatment with a clinically relevant dose of GS-9688 is well tolerated and can induc

80 plant models after treatment with clinically relevant doses of cisplatin.

81 induced by intravenous heroin at low, human-relevant doses.

82 endent temperate dynamics at environmentally relevant E. huxleyi host densities rather than virulent

83 American guidelines have introduced certain relevant elements of flexibility, which were not intrins

84 hips between proteins and other biologically relevant entities: chemicals, phenotypes, complexes, etc

85 However, the relevant EP2-expressing cell types remain unclear.

86 These three biologically relevant examples emphasize the diversity in how the pro

87 ction in breeding numbers at environmentally relevant exposures.

88 In humans and macaque monkeys, socially relevant face processing is accomplished via a distribut

89 ion strategies should target a wide range of relevant factors, including ACEs, socioeconomic deprivat

90 s and used a two-step strategy to select the relevant features.

91 the key physicochemical properties that are relevant for application in (photo)catalysis, bioinorgan

92 udy investigates whether this interaction is relevant for beta cell signaling and plays a role for ne

93 s 58% overall, and in the clinical processes relevant for BP control.

94 hanisms of large cargo secretion that may be relevant for COPII-related diseases.

95 n of SHB to the southern climate, and may be relevant for future population-scale genome-wide analyse

96 hown that gamma oscillations (30-100 Hz) are relevant for neurocircuit function, behavior, and memory

97 elated lineage plasticity, which may also be relevant for other solid tumors.

98 Evaluation of tolerability is increasingly relevant for patients with haematological malignancies t

99 spent, and ensure collection of quality data relevant for policy and practice.

100 if attention modulates the information most relevant for the goal of the decision-maker.

101 e substantially more clustered at the scales relevant for the implemented models, leading to a higher

102 gen signaling strength, a conclusion broadly relevant for the many human diseases in which oligogenic

103 ion of CoA esters of different organic acids relevant for the N-substitution of the 3-phenylisoserine

104 We know little about the spatial scales relevant for the outcomes of such interactions and littl

105 domain cross-talk mechanisms of Pin1 may be relevant for their mechanisms as well.

106 ing and metastatic cancer, these studies are relevant for tissue engineering, biological effects of m

107 chanism of action, which may be particularly relevant for understanding ketamine-induced shifts in mo

108 alances in human brain diseases, is a highly relevant functional measurement poorly investigated due

109 scovery and characterization of biologically relevant GBP-GSL interactions.

110 g and concomitant dysregulated expression of relevant genes.

111 rapid and portable detection of the two most relevant genetic markers linked to azole resistance, the

112 It is challenging to conduct ecologically relevant global change experiments over the long times c

113 ature stimulator that operates at clinically relevant high frequencies.

114 the next generation of more physiologically relevant high-throughput screens (HTS).

115 A 37-year-old male with no relevant history presented to the Emergency Room with ac

116 evant transmission networks of the five most relevant HIV-1 types (B and circulating recombinant form

117 Thus, hPSC-CMs provide an auspicious, relevant human platform to investigate extracellular sig

118 These findings suggest a clinically relevant impact of IVIg on monoclonal antibody clearance

119 migration in 2D unconfined environments are relevant in 1D confined environments.

120 an avenue for environmental risk assessment relevant in a variety of contexts.

121 This is relevant in aging and age-related neurological diseases,

122 erin-15's structural and adhesive properties relevant in disease.

123 rally complex, e.g., layered solids that are relevant in diverse areas of chemistry, physics, and mat

124 on/differentiation functions, and when it is relevant in pathology.

125 vivo tissues, though many considerations are relevant in vivo as well.

126 nfluence of host.guest complexation on other relevant in vivo properties of drugs (e.g. distribution,

127 effective therapeutic treatments of multiple relevant influenza types (H1N1, H3N2, and B) can be achi

128 ion selectively routes the most behaviorally relevant information from the stream of sensory inputs t

129 ronment with saccadic eye movements to bring relevant information into high-acuity foveal vision.

130 ecover DNA from samples with physiologically relevant ionic concentrations without any external elect

131 ructural characterization of atmospherically relevant isoprene-derived organosulfates (OSs) with a mo

132 we quantify cavitation rates on biologically relevant length scales and timescales.

133 revealed a greater number of patients with a relevant lesion (56.1% vs. 39.0%; P = 0.023), resulting

134 ds to be measured, and so, it may not detect relevant, lesser known, exposures.

135 threshold of hypomethylation sufficient for relevant LINE-1 activation and consequential harmful ret

136 Here, we summarize the relevant literature on the persistence and environmental

137 rane potential responses at the behaviorally relevant location.

138 amine mutations as acetylmimetics to map the relevant lysines on actin for INF2 regulation, focusing

139 tumour phenotypic heterogeneity in a disease-relevant manner, with the potential to inform patient-sp

140 reviously applied to other polymers, and the relevant mathematical parameters for their characterizat

141 to assess an individual's level of fear, as relevant measures may not be the same for all individual

142 by mitochondrial activity as a biologically relevant mechanism and demonstrate its contribution to s

143 She had no relevant medical or surgical history; no evidence of rec

144 d to use cellularly derived and biologically relevant membranes for biophysical characterization.

145 uton's tyrosine kinase (BTK) as a clinically relevant model system, we show efficient degradation by

146 cted graft system (CGS) as a physiologically relevant model that consists of three combined regions w

147 This provides a technologically relevant molecular route for simultaneous realization of

148 achieve the targeted synthesis of clinically-relevant molecules in the presence of specific IgG bioma

149 accelerate the search for pharmacologically relevant molecules.

150 easurements on a large class of biologically relevant molecules.

151 e present a method for predicting clinically relevant motion parameters from an ordinary video of a p

152 tion against cashew-induced anaphylaxis in a relevant mouse model.

153 L oxidation in plasma by the physiologically relevant MPO-H(2)O(2)-NO(2) (-) system.

154 This was achieved at biologically relevant, nanomolar concentrations, allowing determinati

155 ircuits interact to mediate an ethologically relevant neural function.

156 rincipal safety outcome, major or clinically relevant non-major bleeding (assessed in participants wh

157 ion, guiding the observer's attention to the relevant object, has remained elusive.

158 ns of a perturbative field theory, we derive relevant observables in closed form.

159 ease, complemented by a systematic review of relevant observational studies.

160 tion techniques, we reveal that contextually-relevant odour engrams are stored within the AON and tha

161 of the dispersed-settled cells can be tissue-relevant only if the cells maintain their 3D tissue stat

162 Rather than consider stress biology to be relevant only under unusual and threatening conditions,

163 king depends on identification of clinically relevant organisms present in a sample.

164 zed approach for establishing benchmarks for relevant outcome measures in surgery.

165 ve that subclassification using these highly relevant parameters could provide a framework for person

166 rocesses and enables experiments with lower, relevant particle concentrations.

167 acteristics (sensitivity and specificity) of relevant pathogen-specific RDTs, we used a mathematical

168 ent of sites positive for select, clinically relevant pathogens.

169 ial crosstalk between these two functionally relevant pathways to coordinate their growth-control fun

170 ut the intervention, taking into account all relevant patient attributes simultaneously, to support m

171 reviously established and novel biologically relevant patterns, demonstrating the potential of our da

172 sease-contributing effects of low SMN in one relevant peripheral organ - skeletal muscle - by selecti

173 Agonist potency, binding affinity, and relevant pharmacological parameters of 15 candidates wer

174 We quantified 12 atherosclerosis-relevant phenotypes related to calcification, proliferat

175 ncluding the ability of affecting clinically relevant phenotypes such as virulence, host colonization

176 in aged mice, and exhibited more clinically relevant phenotypes than those seen in Hfh4-ACE2 transge

177 l drive research progress of physiologically relevant phenotypes.

178 described from 2007 to the end of 2019, yet relevant pioneering transformations are eventually inclu

179 increase survival are observed in clinically relevant platinum and acquired PARPi-resistant patient-d

180 erved feature of the metazoan SAC, since the relevant PLK1 and PP2A-B56 binding motifs have coevolved

181 Here, we tested their role in the clinically relevant polysaccharide conjugate vaccine against Strept

182 en study (Australia, 2013-2014) and obtained relevant population data from the 2011 Australian Census

183 Clinically relevant precursors and early cancers were too small to

184 recession successfully incorporated the most relevant previous classifications into a treatment-orien

185 zing the PaO(2)/FiO(2)-ratio as a clinically relevant primary outcome criterion.

186 A PRO hypothesis and relevant PRO domains were specified in 36 (51%) RCTs.

187 DGF is a relevant problem after kidney transplantation; sufficien

188 study not only identifies a novel psoriasis-relevant proinflammatory pathway, but also proposes the

189 mpact of this approach in regulating disease-relevant protein levels in a light-dependent manner is h

190 er, several major classes of therapeutically relevant proteins have unknown or inaccessible activity

191 odification to alter the functions of immune-relevant proteins; however, our understanding of electro

192 We choose here the biologically relevant protoporphyrin molecule as the electron mediato

193 Here we review the most relevant proximate drivers of masting and outline a rese

194 sh-language databases and a manual review of relevant publications.

195 itative data and using parameter values from relevant published models, and we have tested the model

196 With biologically relevant rates, we find that the genetic circuitry contr

197 nvestigated the co-occurrence of four health-relevant redox-sensitive elements (U, As, V, and Cr) in

198 This is especially relevant regarding the role of genetic and environmental

199 erlying GWAS association signals and reports relevant regulatory elements, tissue contexts and plausi

200 In this review, we summarize recent relevant research contributing to efforts for developing

201 lexes, their biological functions in cancer, relevant research tools and models, as well as the limit

202 To determine the relevant role of AMPK, the effect of SF-PreCon was deter

203 in E. coli-induced myositis and a clinically relevant S. aureus wound infection murine model.

204 ose in measurements of weak but functionally relevant self-generated fields and to those produced by

205 points to inform behavioral choice, but the relevant sensory comparisons and the underlying neural c

206 illations in the alpha to beta range in task-relevant sensory regions have been suggested to play an

207 with an alternative definition of clinically relevant serrated polyps (12.3%; 95% CI, 9.3-15.4; P < .

208 nd drug metabolism in a more physiologically relevant setting.

209 vities of mammalian cells in physiologically relevant settings.

210 There are clinically relevant sex differences in acute and chronic pain mecha

211 ENT The ability to focus on the behaviorally relevant signals is essential for the brain to cope with

212 e timescales depended on selectivity to task-relevant signals.

213 t-source capture and geographic proximity to relevant sinks, specifically enhanced oil recovery (EOR)

214 particularly abundant in neuropathologically relevant sites, such as the motor neuron and the growth

215 describe herein the investigation of disease-relevant small amyloid-beta oligomers by mass spectromet

216 RS2) diets were computed using statistically relevant SNPs.

217 apid diet screener tools in primary care and relevant specialty care prevention settings, discuss the

218 ntly used to calculate time evolution of the relevant spin density matrix and thus predict the ESR sp

219 down target profiling, and to rescue disease-relevant splicing of tau pre-mRNA in a variety of cellul

220 n stimulated cECs can elicit physiologically relevant spread of vasodilatory signals within the highl

221 anding the context and analyzing the role of relevant stakeholders prior to conducting the research,

222 ffer diagnostic and validation tools for all relevant steps.

223 of AgRP neurons to an array of nutritionally-relevant stimuli including food cues, intragastric nutri

224 ows antibacterial activity toward clinically relevant strains.

225 th the exception of a few well-known disease-relevant STRs, normal ranges of repeat counts for most S

226 obility spectrometry, revealing functionally relevant structural attributes.

227 We searched relevant studies in electronic databases and present the

228 ations associated with 10 PICO questions, 20 relevant studies were identified.

229 randomly assigned patients with HFrEF and in relevant subgroups from DAPA-HF and EMPEROR-Reduced tria

230 ically competent assays with physiologically relevant substrates and the previously unappreciated con

231 n individuals, but little is known about the relevant synaptic changes associated with social transmi

232 showed no evidence for a severe, clinically relevant systemic immunodeficiency.

233 at are not sensitive to the diverse range of relevant target species.

234 echanisms.SIGNIFICANCE STATEMENT Associating relevant target stimuli with reward value can enhance th

235 miR-125a-5p and L-plastin may be relevant targets for increasing in vitro platelet manufa

236 drugs inhibiting a broad spectrum of cancer-relevant targets.

237 mic therapy (PDT) is an important clinically relevant therapeutic modality that has proven to compens

238 trials using L-AZM as a novel and clinically relevant therapeutic target to improve cardiac recovery

239 dynamic biological systems at experimentally relevant time resolutions, such as those afforded by sin

240 The detected features were reduced to 130 relevant time trends related to TrOCs for identification

241 However, specific and physiologically relevant tissue actions of TRPV4, stretch-independent re

242 ng functional validation studies to the most relevant tissues and can gain power as fine-mapping reso

243 transdifferentiation or vasculature in human-relevant TMJ OA large animal models or in human TMJ tiss

244 We demonstrate soft devices relevant to a broad range of disciplines: models that si

245 of 22q11.2 CNVs on neurobehavioral measures relevant to ASD and psychosis in 106 22q11.2 deletion ca

246 as measures of health and development highly relevant to ASD.

247 Peritumoral-rim radiomic features were most relevant to both classifications (p <= 0.044).

248 ed, COU, assessment of biomarker performance relevant to both the need and COU, assessment of biomark

249 as a molecular scaffold; these insights are relevant to CD81's varied roles in both health and disea

250 diated memory responses to SARS-CoV-2, it is relevant to consider their impact both on COVID-19 disea

251 ways into biological processes that are more relevant to ecotoxicology based on the input from expert

252 es and electrodeposition to create materials relevant to energy challenges including photoconductors

253 regulating fundamental tendon cell functions relevant to exercise-induced adaptation and mechanothera

254 Transcript length (relevant to gene delivery strategies) correlated signifi

255 pair, mutations, and cytotoxicity is broadly relevant to health.

256 in type of a hiatal hernia may be clinically relevant to help understand changing or worsening sympto

257 te increases cellular infection with viruses relevant to human and animal health, including influenza

258 This paper reviews (1) programs most relevant to infectious diseases in the 2018 SUPPORT Act;

259 verning the mammalian 'deactive transition' (relevant to ischemia-reperfusion injury) and their effec

260 nd late-stage functionalization of scaffolds relevant to medicinal chemistry.

261 uctural and functional mutational signatures relevant to Mendelian disorders and the prioritization o

262 , and double Akt1/3 mutant mice in behaviors relevant to neuropsychiatric disorders.

263 LDs with cellular metabolism are unclear but relevant to obesity-related diseases.

264 ns in supporting conscious cognition that is relevant to our understanding of clinical disorders of c

265 y focused on coronavirus disease 2019 remain relevant to patients with coronavirus disease 2019.

266 e-and expressed HB surface antigen at levels relevant to patients.

267 te catalysis and toxin function which may be relevant to specific TA-mediated responses in diverse ge

268 ize across tasks, particularly where stimuli relevant to the associative memory task appeared.

269 active site suggests that Ca(2+) binding is relevant to the catalytic activity.

270 nd the evidentiary criteria of the biomarker relevant to the COU compared with the current standard o

271 , assessment of biomarker benefits and risks relevant to the COU, and the evidentiary criteria of the

272 ing spectrum of its clinical applications is relevant to the current emphasis on precision medicine a

273 ntain the protective functions of astrocytes relevant to the development of motor deficits in mice.

274 ter than previously considered at conditions relevant to the Earth's upper mantle, with important imp

275 We propose a set of five key principles relevant to the European Medicines Agency, European medi

276 l roles in metalloid transformations and are relevant to the geomicrobiology of environmental metallo

277 growth of M. intracellulare under conditions relevant to the host environment.

278 he activation of Gene Ontology (GO) pathways relevant to the human disease, such as type I and II int

279 ibosome recycling, and could be particularly relevant to the synthesis and cotranslational behavior o

280 vity in primary sensory regions not directly relevant to the task (e.g., neural activity in visual co

281 s voicing periodicity, that are not directly relevant to the word recognition task.

282 tor, are TRIAD1 substrates that are possibly relevant to these activities.

283 symptomatic toxicities that are particularly relevant to treatment tolerability for patients living w

284 hypomorphic loss of BCCIP functions is more relevant to tumorigenesis.

285 Metabolic flux analysis (MFA) is highly relevant to understanding metabolic mechanisms of variou

286 tructural (i.e., network-based) features are relevant to understanding the functional (i.e., fitness-

287 alf-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cance

288 at are associated with numerous ecologically relevant traits, as well as soil and climate characteris

289 s sampled across China were used to identify relevant transmission networks of the five most relevant

290 There were no clinically relevant treatment-related serious adverse events.

291 ls using in silico deletion to find the most relevant TRs.

292 are being pursued for predicting clinically relevant tumour behaviours, such as treatment response a

293 results also indicate that feedback is more relevant under uncertainty, and its effectiveness can be

294 storation initiatives by providing a locally relevant understanding of the causes of mangrove loss.

295 ted to any of the psychological life history-relevant variables measured (including short- vs. long-t

296 nts might be based on point estimates of the relevant variables, rather than on their full probabilit

297 y of potent and selective antibodies against relevant viral epitopes.

298 When relevant, we provide information based on sex and common

299 Reusability of sensors is relevant when aiming to decrease variation between measu

300 edicines displaying liver autoimmune disease-relevant yet ubiquitously expressed antigens can blunt v