1 e and its contributions to neuronal function
remains to be achieved.
2 ge where the field stands currently and what
remains to be achieved.
3 In contrast, several bioinformatic issues
remain to be addressed in processing DIA data and the de
4 ts of best practice, and the challenges that
remain to be addressed.
5 , several questions related to HIV infection
remain to be addressed.
6 have received scant scrutiny and, crucially,
remain to be addressed.
7 what in our view are the biggest challenges
remaining to be addressed.
8 gnaling pathway attenuates colon cancer risk
remains to be addressed.
9 NAs is still on-going, target identification
remains to be an essential and challenging step precedin
10 The questions that
remain to be answered is how early can RS detect and ide
11 obtained, and the theoretical questions that
remain to be answered.
12 nd outline a few of the major questions that
remain to be answered.
13 Lastly, we discuss imperative questions
remaining to be answered.
14 me in patients with chronic plaque psoriasis
remains to be ascertained.
15 enetic background and co-occurring mutations
remains to be assessed when using newly approved antileu
16 s a broad spectrum of neurological disorders
remains to be assessed.
17 nctions distinct from adaptive immunity that
remain to be characterized experimentally.
18 midazole lower ligand diversity in cobamides
remain to be characterized, and the precise role of the
19 ring iron reduction by different methanogens
remain to be characterized.
20 rse set of other putative defense genes that
remain to be characterized.
21 lear-encoded photosynthesis-associated genes
remains to be characterized in detail.
22 er, the signaling pathway downstream of CDK2
remains to be characterized, and it is also unclear whet
23 derlying ASM in normal and neoplastic cells,
remain to be clarified.
24 ons in these striatal-related diseases still
remain to be clarified.
25 ntial alterations in nonpsychotic relatives,
remain to be clarified.
26 ctivity (AHR), inflammation and eosinophilia
remained to be clarified.
27 rder (MDD) patients who exhibit inflammation
remains to be clarified, as the heterogeneity in inflamm
28 sus suppressing actions in aversive contexts
remains to be clarified.
29 utions to instigating or suppressing actions
remains to be clarified.
30 icular compartments in severe COVID-19 lungs
remains to be clarified.
31 f astroglial TDP-43 loss to ALS pathobiology
remains to be clarified.
32 of these lncRNAs to the pathogenesis of T1D
remains to be clarified.
33 role of microglial mTOR in acquired epilepsy
remains to be clarified.
34 molecular regulation of neuropeptide release
remains to be clarified.
35 stasis in the cutaneous manifestations of OS
remains to be clarified.
36 cytoprotection, its functional significance
remains to be completely defined.
37 To date it
remains to be completely elucidated how the altered ener
38 olecular subtypes whose functional relevance
remains to be comprehensively established.
39 Nevertheless, maximum production potential
remains to be confirmed experimentally, and further tech
40 to the binding thermodynamics, this release
remains to be confirmed through a direct observation of
41 However, the molecular mechanism
remained to be deciphered.
42 the survival and function of myogenic cells
remains to be deciphered.
43 edical interventions in the clinical setting
remain to be defined in further studies.
44 Although optimal AA intake amounts
remain to be defined, we strongly recommend that AA shou
45 al underpinnings of diverse disease outcomes
remain to be defined.
46 functional consequences of that association,
remain to be defined.
47 mune cell activation leading to TLOs in COPD
remain to be defined.Objectives: To examine the role of
48 molecular pathogenesis of these alterations
remains to be defined, amyloid-beta is a likely contribu
49 ircuit for the VMH regulation of food intake
remains to be defined.
50 er physiological and pathological conditions
remains to be defined.
51 ays without interruption of genome integrity
remains to be defined.
52 variant on viral spread and vaccine efficacy
remains to be defined.
53 e complications of influenza virus infection
remains to be defined.
54 development and progression of solid tumors
remains to be defined.
55 function of NP ExoN in arenavirus infection
remains to be defined.
56 ns (RBPs) mediated control of stem cell fate
remains to be defined.
57 ion to macrophage functions and host defense
remains to be delineated.
58 beneficial impact of S1R in the ALS context
remain to be demonstrated in vivo.
59 While the specificity of this marker
remains to be demonstrated, it complied with both criter
60 conclusive, and hence reproductive restraint
remains to be demonstrated.
61 process with minimal infrastructure support
remains to be demonstrated.
62 property of cortical networks, although this
remains to be demonstrated.
63 s methanogens which escape routine detection
remains to be described.
64 he mechanisms underlying these relationships
remain to be determined, the patterns of association exh
65 nes (Flcn, Map1lc3b, Me2, Prkd2, and Scarb2)
remain to be determined.
66 liosis [10, 11], other pathogenic mechanisms
remain to be determined.
67 of proviral reservoirs in elite controllers
remain to be determined.
68 he role of differential expression isoforms,
remain to be determined.
69 at bring about these behavioral consequences
remain to be determined.
70 chanistic details underlying these processes
remain to be determined.
71 ss across different cancers for reasons that
remain to be determined.
72 However, the mechanisms for both processes
remain to be determined.
73 yndrome coronavirus 2 (SARS-CoV-2) infection
remain to be determined.
74 his tissue to the glucose-tolerant phenotype
remain to be determined.
75 emic, many features of COVID-19 pathogenesis
remain to be determined.
76 oids; however, the optimal dose and duration
remain to be determined.
77 ys a role in maintenance of genome stability
remain to be determined.
78 and mechanism of PINCH-1 in cancer, however,
remain to be determined.
79 lar mechanisms responsible for this response
remain to be determined.
80 s in the absence of excessive grape ripeness
remained to be determined.
81 ver, the adequacy of its desensitization has
remained to be determined.
82 stimate of the frequency of aortic aneurysms
remains to be determined as the majority of subjects hav
83 It
remains to be determined if the co-morbid concurrence of
84 cross-reactive T cells on clinical outcomes
remains to be determined in larger cohorts.
85 late to the cognitive and affective deficits
remains to be determined with a large cohort of particip
86 of these alterations in the patient outcome
remains to be determined, our findings encourage future
87 ich T. brucei infection causes these changes
remains to be determined, our findings suggest that the
88 mplementing serological testing for COVID-19
remains to be determined, particularly in low-prevalence
89 Although the optimal postremission therapy
remains to be determined, the high remission rate in de
90 the clinical utility of the identified loci
remains to be determined, they can be used as resources
91 gnificance of the different BRCA2 assemblies
remains to be determined.
92 isoforms whose biological relevance largely
remains to be determined.
93 cell fate and mammary tumorigenesis in vivo
remains to be determined.
94 equences of the formation of these complexes
remains to be determined.
95 role in predisposing to hip OA in later life
remains to be determined.
96 the effects of rapid-acting antidepressants
remains to be determined.
97 physiological aging and spatial distribution
remains to be determined.
98 the case of incomplete forms of the disease,
remains to be determined.
99 BTK occupancy on long-term clinical outcomes
remains to be determined.
100 r LTB(4) directly activates the inflammasome
remains to be determined.
101 otically assisted approach is cost-effective
remains to be determined.
102 xplains other gene-environment interactions,
remains to be determined.
103 participate in the palatal expansion process
remains to be determined.
104 ver, its specific role in CRISPR-Cas defense
remains to be determined.
105 an contribute to bNAb-mediated viral control
remains to be determined.
106 the logic underlying their very formulation
remains to be determined.
107 ecular role of hepcidin in COPD pathogenesis
remains to be determined.
108 ontributed to the success of the host shift,
remains to be determined.
109 protection against infection with SARS-CoV-2
remains to be determined.
110 l the pathways are coupled to ATP hydrolysis
remains to be determined.
111 her and how these changes shift fibrinolysis
remains to be determined.
112 of a functional full-length CYP102A1 enzyme
remains to be determined.
113 ursor (App) mRNA, but the detailed mechanism
remains to be determined.
114 CK promoting insulin release in human islets
remains to be determined.
115 be reduced with treatment in intensive care
remains to be determined.
116 but an effect on spine structural plasticity
remains to be determined.
117 d flexible synthetic route to KA and analogs
remains to be developed.
118 One fundamental question that
remains to be directly addressed is whether the structur
119 tening to impede invasion and metastasis, it
remains to be directly demonstrated that tumor cells sof
120 ity that thousands or more bifunctional CRMs
remain to be discovered in Drosophila and 10(4)-10(5) in
121 tive genes for more than half such disorders
remain to be discovered(1).
122 t there are additional functions of MOF that
remain to be discovered.
123 of uncharacterized natural antibiotics that
remain to be discovered.
124 ndoubtedly more pathogenic repeat expansions
remain to be discovered.
125 ) reorganization during rhizobial infections
remain to be discovered.
126 tory signals controlling their proliferation
remain to be discovered.
127 d architecture of their cell walls, but much
remains to be discovered about how the nanoscale assembl
128 t the functioning of these enzymes, but more
remains to be discovered about their cellular roles and
129 Much
remains to be discovered, however, as methodological var
130 Though much
remains to be discovered, the fundamental neurocircuitry
131 structural changes in skeletal muscle tissue
remains to be discovered.
132 genetic susceptibility to cutaneous melanoma
remains to be discovered.
133 otility, while the function of the other two
remains to be discovered.
134 adipose tissue, but the underlying mechanism
remains to be discovered.
135 tance is limited, and its physiological role
remains to be dissected.
136 Much work
remains to be done in the development of easy-to-use pac
137 nt state of play and emphasize the work that
remains to be done over the next few years so that, ulti
138 Although more work
remains to be done to improve and possibly standardize m
139 ASCO acknowledges that much work
remains to be done, by all cancer stakeholders at the sy
140 Although much
remains to be done, considerable preclinical evidence is
141 Although much work
remains to be done, effective strategies targeting telom
142 C; however, a substantial amount of research
remains to be done, including identifying the optimal th
143 on's disease has advanced considerably, much
remains to be done.
144 ines to enhanced immune protection therefore
remain to be elucidated in other experimental scenarios,
145 biological and psychological processes that
remain to be elucidated with more in-depth analyses of t
146 l survival and apoptosis signaling in cancer
remain to be elucidated.
147 mechanistic connection with acid production
remain to be elucidated.
148 n, but their effects on pollen allergenicity
remain to be elucidated.
149 lular mechanisms underpinning their immunity
remain to be elucidated.
150 any aspects of extracellular vesicle biology
remain to be elucidated.
151 d catabolic pathways, whose exact activities
remain to be elucidated.
152 n and how these are affected by normal aging
remain to be elucidated.
153 pathology of heme-induced barrier disruption
remain to be elucidated.
154 by which cytokines modulate pain processing
remain to be elucidated.
155 arly postnatal brain through mechanisms that
remain to be elucidated.
156 al mechanisms underlying tumorigenesis often
remain to be elucidated.
157 ynthesis; however, the underlying mechanisms
remain to be elucidated.
158 ontribute to leukemia pathogenesis, however,
remain to be elucidated.
159 resident mesenchymal stromal cells (LR-MSCs)
remain to be elucidated.
160 The precise pathomechanisms
remain to be elucidated.
161 ying mechanisms inducing these abnormalities
remain to be elucidated.
162 en pathogenic fungi and the human host, much
remains to be elucidated concerning the molecular mechan
163 However, it
remains to be elucidated how much pore fluid pressure de
164 silicon in defense molecular mechanism still
remains to be elucidated in finger millet.
165 Specifically, it
remains to be elucidated whether changes in frequency on
166 gh the mechanism of proton permeation in Hv1
remains to be elucidated, a series of small molecules ha
167 The mechanism of RPE65 protein regulation
remains to be elucidated, but the current work suggests
168 However, its role in CNV
remains to be elucidated.
169 How such compounds act in concert
remains to be elucidated.
170 Whether this effect is scale dependent
remains to be elucidated.
171 state and inflammation in the diabetic heart
remains to be elucidated.
172 lipids in Wolbachia-mediated virus blocking
remains to be elucidated.
173 plication for the elicitation of anaphylaxis
remains to be elucidated.
174 , such as protein-protein interaction (PPI),
remains to be elucidated.
175 h pathway in cardiac progenitor cell biology
remains to be elucidated.
176 epidermal barrier formation and homeostasis
remains to be elucidated.
177 kinase, in the induction of astrocytogenesis
remains to be elucidated.
178 by inhibitors of Type I and Type II priming,
remains to be elucidated.SIGNIFICANCE STATEMENT Commonly
179 mechanisms of action and resistance in vivo
remain to be established, and there is no way of predict
180 larger organisms is challenging, though, and
remains to be established for models of chronic heart fa
181 metabolism to support the dynamic phenotype
remains to be established.
182 FL) transcripts required for normal function
remains to be established.
183 stematic kidney biopsy should become routine
remains to be established.
184 al relationship between these two conditions
remains to be established.
185 ria to function as biological magnetosensors
remains to be established.
186 (CD) who have undergone ileocecal resection
remains to be established.
187 ship between GPe neuron classes and movement
remains to be established.
188 nsfections can be performed in these species
remains to be evaluated.
189 dynamics of CD4(+) T cell memory development
remain to be examined at genome scale.
190 LGE with electrogram fractionation and delay
remains to be examined.
191 cesses underlying this 'molecular diversity'
remain to be explained.
192 sively studied, but their shaping mechanisms
remain to be explored.
193 roaches targeting senescence-associated CSCs
remain to be explored.
194 ulate Ags, the molecular mechanisms of which
remain to be explored.
195 ations to influence cancer stem cells (CSCs)
remain to be explored.
196 The use of food structuring approaches
remains to be explored for sugar reduction in yogurt.
197 egulation of nuclear-encoded genes in planta
remains to be explored.
198 ether this link has any causal aspects to it
remains to be explored.
199 application within a diverse set of circuits
remains to be explored.
200 Many of these proposed mechanisms
remain to be fully characterized or confirmed in vivo, g
201 interactions among various components of DOM
remain to be fully characterized.
202 variable cell-specificity of tauopathy thus
remain to be fully defined.
203 However, cilia in the visual relay center
remain to be fully described.
204 members of the Keroplatinae subfamily still
remain to be fully elucidated.
205 anisms of posttranslational control of RUNX2
remain to be fully elucidated.
206 of HSV-specific human CD4(+) T cell epitopes
remain to be fully elucidated.
207 skeleton; however, the underlying mechanisms
remain to be fully elucidated.
208 neurocircuitry underlying these alterations
remain to be fully elucidated.
209 is and on vascular smooth muscle cells (SMC)
remain to be fully elucidated.
210 e phenotypic consequences of such variation,
remain to be fully explored.
211 at regulate psoriasis-like skin inflammation
remain to be fully understood.
212 cular pathways that regulate OEC development
remains to be fully deciphered.
213 But its function
remains to be fully defined.
214 r basis of this bi-directional communication
remains to be fully determined.
215 ter studies, and the epidemiology of frailty
remains to be fully elucidated in a real-world surgical
216 ) for cancer progression and drug resistance
remains to be fully elucidated in the clinic.
217 While the pathogenic potential of the virus
remains to be fully elucidated, its basal phylogeny and
218 However, the role of autophagy in ILC2s
remains to be fully elucidated.
219 1, iNKT2, and iNKT17 in herpesvirus immunity
remains to be fully elucidated.
220 onal regulation of EC and tumor angiogenesis
remains to be fully elucidated.
221 nal role played by astrocytes in this region
remains to be fully elucidated.
222 s supporting tumor progression, whose origin
remains to be fully elucidated.
223 nd maintenance of the rhizosphere microbiota
remains to be fully elucidated.
224 ational regulation coordinates VRN2 activity
remains to be fully established.
225 However, the underlying mechanism
remains to be fully established.
226 ost immunity against other pathogen families
remains to be fully explored.
227 therapeutic potential of targeting mitophagy
remains to be fully explored.
228 The role of myeloid cells in this setting
remains to be fully investigated.
229 ism of how EF-Tu is involved in proofreading
remains to be fully resolved.
230 er disease, and the peripheral immune system
remains to be fully understood.
231 ycardia (VT) in structurally abnormal hearts
remains to be fully validated.
232 e threshold; however, the precise mechanisms
remain to be further explored.
233 between colorectal cancer stemness and SIRT1
remains to be further clarified.
234 e interactions, the GSL ligands of most GBPs
remain to be identified and the mechanisms controlling r
235 h effort, motifs that promote LLSP secretion
remain to be identified.
236 nsport to the synapse in axons and dendrites
remain to be identified.
237 exact synaptic components targeted by Abetao
remain to be identified.
238 ulations required for this protective effect
remain to be identified.
239 by variants and the target genes of such REs
remain to be identified.
240 s) of the glyceollin gene regulatory network
remain to be identified.
241 factors induced by radiation on tumor cells
remain to be identified.
242 r disease-related common genetic variability
remains to be identified and the work in identifying rar
243 nAChR) subtypes, but the activity of Cca1669
remains to be identified.
244 or adapts to nutrient-poor microenvironments
remain to be investigated.
245 ide exchange on G proteins besides Galpha(i)
remain to be investigated.
246 -signaling cascades, but most OTUs functions
remain to be investigated.
247 structure of XyG has been well studied, much
remains to be learned about its biosynthesis.
248 Thus, much
remains to be learned about the mechanisms describing th
249 Here, we emphasize how much
remains to be learned about the RNA targets of human pse
250 Much
remains to be learned with respect to the relative power
251 However, much
remains to be learnt about how NAD(+) influences human h
252 ubunit vaccine against Plasmodium falciparum
remains to be licensed and deployed.
253 dementia disorders have advanced rapidly but
remain to be more widely implemented in practice.
254 owever, the human TRPV1-associated signaling
remains to be obscure.
255 nmentally friendly, effective seed treatment
remain to be optimized and tested for high-value special
256 , quality control and independent validation
remain to be performed to add prognostic information abo
257 role of the eIF3 complex and of its subunits
remains to be precisely defined.
258 outine pharmacological and medical scenarios
remains to be realized.
259 tions and coupling of H(2), NAD(P)H, and Fdx
remain to be resolved.
260 ying mechanisms that control these processes
remain to be resolved.
261 tions for interrupting parasite transmission
remain to be resolved.
262 ilies, and highlight emerging questions that
remain to be resolved.
263 Despite this, much
remains to be resolved on the mechanism of their activat
264 tribution of H. axyridis towards the equator
remains to be resolved.
265 esponse to ICB in renal cell carcinoma (RCC)
remains to be resolved.
266 ation, but the long-term safety and efficacy
remain to be scientifically established.
267 lved in the bacteria-nanopattern interaction
remain to be seen.
268 ctiveness and sustainability of these pilots
remain to be seen.
269 It
remains to be seen if such an endotype truly exists and
270 mits is a useful strategy for CAD prevention
remains to be seen.
271 But it
remains to be shown that a detail-focused processing bia
272 al challenges for sulfide electrolytes still
remain to be solved, including their narrow electrochemi
273 issues, apparent contradictions, and puzzles
remain to be solved.
274 velled, Egl-10, and pleckstrin domain (DEP1)
remains to be structurally characterized.
275 gress in protein structure prediction, a lot
remains to be studied at this merging superhighway of de
276 owever, the role of IL-17RD in tumor biology
remains to be studied in vivo.
277 atherosclerotic cardiovascular disease, but
remain to be tested further and confirmed in clinical tr
278 role of RPEs in episodic memory acquisition
remain to be tested.
279 This hypothesis
remains to be tested in cellulo Here, we explore the rel
280 The major focus in the field
remains to be the improvement of the overall performance
281 The evolution of influenza viruses
remains to be the main obstacle in the effectiveness of
282 Across different lipid nanocarriers, NLC
remains to be the safest, stable, biocompatible and cost
283 fied the characteristics of participants who
remained to be treated using a modified Poisson regressi
284 to host metabolism, but specific mechanisms
remain to be uncovered.
285 g reasons for this impaired NK cell function
remain to be uncovered.
286 jor genetic basic underlying sex chromosomes
remains to be uncovered.
287 of the hippocampus-dependent memory system,
remain to be understood.
288 ctions of ELAV proteins during LTM formation
remained to be understood.
289 significant proportion of WTs; however, much
remains to be understood about how it contributes to tum
290 f coordinated gene expression; however, much
remains to be understood about how such networks of cros
291 causes of early-onset genetic dystonia, much
remains to be understood about the full spectrum of the
292 k phloem by transporters is complex and much
remains to be understood about this phenomenon in the wa
293 However, much
remains to be understood about what governs which region
294 ease-specific tissues at the molecular level
remains to be understood.
295 ocesses in vivo and development in metazoans
remains to be understood.
296 he detailed architecture of the intact virus
remains to be unveiled.
297 the functional roles of most of these genes
remain to be validated.
298 ogical role of the observed alternative pose
remains to be validated, our structural results hint at
299 Unlike microsaccades, drifts
remain to be viewed as largely random eye movements.
300 mune responses during C. difficile infection
remains to be well described.