1 pproached modern levels ( approximately
21%)
remains unresolved.
2 acy, many details of the mechanism of
action remain unresolved, despite the importance in translating
3 ails of its assembly and mechanism of
action remain unresolved.
4 cular drug for which the mechanism of
action remains unresolved.
5 racellular environment for long-range
action remains unresolved.
6 vance of this to pharmacotherapeutic
actions remains unresolved.
7 ating that how PLK1 controls RhoA
activation remains unresolved.
8 these mutations confer constitutive
activity remain unresolved.
9 g, the mechanisms that control Hsf1
activity remain unresolved.
10 hanisms of this specific P stress
adaptation remain unresolved, we reveal a detailed phospholipid-rec
11 ificant reductions in AI, but IDA and IDA+
AI remain unresolved.
12 nsgene silencing and epigenetic
alternations remains unresolved for most transgenic plants.
13 plasticity in small mammals at high
altitude remains unresolved.
14 low) or through environmental selection,
and remains unresolved due to lack of empirical data.
15 te interphase and Li trapping at the
anodes,
remains unresolved.
16 cardiac contractility and
arrhythmogenicity remain unresolved.
17 h site density and under reducing
atmosphere remains unresolved.
18 uished in response to microtubule
attachment remains unresolved.
19 hwann cells that myelinate Ia-afferent
axons remains unresolved.
20 gnaling functions, but their molecular
basis remains unresolved.
21 and the complete picture for their
behavior remains unresolved.
22 ity of Purkinje cells during motor
behaviour remains unresolved.
23 ich 17alpha-estradiol elicits these
benefits remain unresolved.
24 GF19, FGF21, and FGF1 in the mammalian
brain remains unresolved.
25 has been the subject of numerous studies
but remained unresolved due to difficulties in identifying d
26 iac disease in survivors of childhood
cancer remain unresolved.
27 50% of cases, the underlying molecular
cause remains unresolved.
28 Its
causes remain unresolved, with tectonic restrictions to the Atl
29 he mechanism of mtDNA movement between
cells remains unresolved.
30 that despite some characteristic
challenges remaining unresolved, designed polypharmacology holds en
31 these successional forests to climate
change remains unresolved.
32 hanism(s) driving this conformational
change remains unresolved and in most cases high-resolution str
33 or closing of the pore domain's ion
channel remains unresolved.
34 s producing these behavioral
characteristics remain unresolved.
35 , many mechanistic aspects of this
chemistry remain unresolved including the full ligand set of the s
36 igenome in regulating early cell-fate
choice remains unresolved, and the coordination between differe
37 mber of families mapping to the X-
chromosome remained unresolved suggesting that more XLID genes or l
38 urons that lie at the core of these
circuits remain unresolved.
39 nderlying selective nerve pathology in
CMT2D remain unresolved, as does the cause of the mild-to-mode
40 between plant and soil microbial
communities remain unresolved.
41 ylase (HDAC) cooperate within NuRD
complexes remains unresolved.
42 rspective on why the utility of this
concept remains unresolved.
43 ternmost frontier of the European
continent,
remains unresolved.
44 s, but the exact nature of its
contributions remains unresolved.
45 ch vocalizations are produced and
controlled remain unresolved because of the extreme difficulty in o
46 y, and geographical footprint of YDS
cooling remain unresolved and pose a challenge to our understand
47 for decades, yet their behavioral
correlates remain unresolved.
48 tect themselves from the toxicity of
cyanide remained unresolved.
49 ht trigger the polymerizing arm of the
cycle remains unresolved.
50 (100 m to tens of kilometers, hours to
days)
remain unresolved due to a lack of synoptic measurements
51 inhibition (HDACi) induces tumor cell
death remain unresolved.
52 changes, and long-term risk of sudden
death remain unresolved and need further research.
53 ed subjects, the underlying molecular
defect remains unresolved.
54 ions of the nervous system in Cbl
deficiency remain unresolved, the Cd320(-/-) mouse provides a uniqu
55 but how it drives motor neuron
degeneration remains unresolved.
56 tabolisms of bacterial hydrocarbon
degraders remain unresolved.
57 NisB uses glutamate to catalyse
dehydration remains unresolved.
58 cuprate superconductors at low hole
density remains unresolved.
59 usative agent, Pseudogymnoascus
destructans,
remains unresolved [2,4].
60 vement in homeostasis and cancer
development remain unresolved issues.
61 lls to respond to glucose in type-2
diabetes remain unresolved.
62 macrophage polarization and
differentiation remain unresolved.
63 temperature; however, regional
discrepancies remain unresolved.
64 dual VSMCs, which underlie vascular
disease,
remain unresolved.
65 he origins and spread of treponemal
diseases remain unresolved, including syphilis' potential introdu
66 of water in hominin evolution and
dispersal remains unresolved.
67 However, the specific sources of glacier
DOC remain unresolved.
68 to determine efficacy of remyelinating
drugs remains unresolved.
69 hus, the question of their temporal
dynamics remains unresolved.
70 ecise mechanism of this immune
dysregulation remains unresolved.
71 infection, but the generality of this
effect remains unresolved.
72 al relationships and tissue-specific
effects remain unresolved.
73 the mechanism associated with these
effects remains unresolved.
74 ormation and function of the native
envelope remain unresolved.
75 rial plasticity in cold hypoxic
environments remains unresolved.
76 ause of intellectual disability and
epilepsy remain unresolved.
77 responsible for its formation and
evolution remain unresolved.
78 lution, many questions about penis
evolution remain unresolved.
79 wever, the role of coding sequence
evolution remains unresolved.
80 es muscle activity during movement
execution remains unresolved.
81 cell populations appear and stably co-
exist remains unresolved.
82 however, the origins of salmon
exploitation remain unresolved.
83 related to environmental asbestos
exposures remain unresolved.
84 er, the role of Lyn in mucin gene
expression remains unresolved.
85 the evolutionary significance of
Facivermis remains unresolved.
86 or shared or nonshared environmental
factors remains unresolved.
87 tionships among major lineages in the
family remain unresolved, hampering comparative research.
88 ing or aerobic capacity, and its
feasibility remains unresolved in patients with heart failure.
89 than 150 years, yet many essential
features remain unresolved.
90 The mechanism of tau
fibrillogenesis remains unresolved, particularly early events that trigg
91 on sensitivities to temperature
fluctuations remains unresolved.
92 e strength of bottom-up and top-down
forcing remain unresolved.
93 romising the advance of the replication
fork remains unresolved.
94 rsors of colorectal cancer (CRC),
frequently remains unresolved in patients with adenomatous polyposi
95 e malaria parasite, yet its natural
function remains unresolved.
96 er's disease, yet its physiological
function remains unresolved.
97 TgDrpC, whose
function remains unresolved, is unusual in that it lacks a conser
98 Their
functions remain unresolved.
99 The reasons for this complex
geometry remain unresolved.
100 SIF tracks spatiotemporal variations in
GPP remains unresolved.
101 ystematics and divergence times of the
group remain unresolved.
102 the mechanism underlying the antagonism
has remained unresolved.
103 ive migration of normal epithelial cells
has remained unresolved.
104 sist on nutritionally insufficient diets
has remained unresolved.
105 ut the structural basis of these effects
has remained unresolved.
106 nd evolutionary importance of this group
has remained unresolved, largely because of their poorly con
107 In this work we propose that LPB
has remained unresolved because previous research has neglec
108 in the nucleus, its role in mitochondria
has remained unresolved.
109 ions independently of Hrd1 stabilization
has remained unresolved.
110 lastocysts, but their X chromosome state
has remained unresolved.
111 The route other beta-barrel proteins use
has remained unresolved.
112 TFs influence chromatin dynamics at ZGA
has remained unresolved.
113 the molecular details of AZ1 inhibition
have remained unresolved, stymieing further development of th
114 , whose composition and chemical nature
have remained unresolved until recently.
115 the mechanisms triggering disease onset
have remained unresolved.
116 ronts; however, details of this process
have remained unresolved.
117 lecular mechanisms initiating tolerance
have remained unresolved to date.
118 hondrial Ca2+ plays a mechanistic role in
HF remains unresolved.
119 tion of nanoscale metallic glasses,
however,
remain unresolved.
120 underlying the surround of the AII,
however,
remains unresolved.
121 on to reprogram gene transcription,
however,
remains unresolved.
122 amic interactions with CRISPR-based
immunity remain unresolved.
123 tive way, particularly in high-risk
infants,
remains unresolved.
124 g Mycobacterium tuberculosis (Mtb)
infection remains unresolved.
125 underlying mechanism that sustains
infection remains unresolved.
126 ues through the course of chronic
infections remains unresolved.
127 l communities, but their combined
influences remain unresolved.
128 lization of lasing with electrical
injection-
remains unresolved, largely due to fast nonradiative Aug
129 hanisms of renal ischemia-reperfusion
injury remain unresolved, and effective therapies are lacking.
130 m channel function to arrhythmic
instability remain unresolved.
131 erstanding of this lipid-protein
interaction remains unresolved.
132 ) cause many infections, some
investigations remain unresolved.
133 lemic conditions and the mechanisms
involved remain unresolved.
134 c mechanisms and the glial subtypes
involved remain unresolved, infection of NG2 glia was recently ob
135 y CAZ proteins and their respective
isoforms remains unresolved.
136 ing Editor's assessment is that major
issues remain unresolved (see decision letter).
137 dical relevance, basic SULT mechanism
issues remain unresolved.
138 ing Editor's assessment is that minor
issues remain unresolved (see decision letter).
139 Despite such enthusiasm, a number of
issues remain unresolved regarding the nature of MMN impairment
140 It remains unresolved how the amount of rotation occurring
141 It remains unresolved to what extent these exceptional heat
142 It remains unresolved whether increased sarcoplasmic calciu
143 rimarily via undirected random walks, but
it remains unresolved how these random walks generate an ef
144 However,
it remains unresolved how acute and chronic changes in ener
145 However,
it remains unresolved how multiple BMPs would cooperate to
146 However,
it remains unresolved what mediates these spectral shifts a
147 However,
it remains unresolved whether changes in one's own pain sen
148 However,
it remains unresolved whether feeding leads to endogenous o
149 However,
it remains unresolved whether schizophrenia-associated cort
150 importance to diverse human populations,
it remains unresolved how the bottle gourd came to be so wi
151 Despite extensive studies,
it remains unresolved how cis-elements just downstream of t
152 l telencephalon (pallium) of vertebrates,
it remains unresolved which ancestral neurogenesis mode pre
153 Yet,
it remains unresolved how sorting into diverging vesicular
154 in speech encoding at the subcortical
level remains unresolved.
155 tions concerning their biology and
lifestyle remain unresolved.
156 f leaf mitochondrial metabolism in the
light remain unresolved.
157 ic positions of Halteriida and
Linconophoria remain unresolved and are thus regarded as incertae sedi
158 genetic relationships of many major
lineages remain unresolved.
159 gin of the human-like pattern of pelvic
list remains unresolved.
160 tributions of variants residing in risk
loci remain unresolved.
161 ntibodies neutralize toxins in the gut
lumen remains unresolved, although it has been suggested that
162 e most fundamental aspects of
macroautophagy remain unresolved.
163 response to the development of
malignancies remains unresolved.
164 ominin hands became principally
manipulative remains unresolved.
165 e arrested state in these abundant
materials remains unresolved.
166 ociated with major depressive disorder (
MDD)
remains unresolved.
167 The causal gene and underlying
mechanism remain unresolved.
168 to their offspring, but the exact
mechanism remains unresolved.
169 ivation has been observed, but the
mechanism remains unresolved because they lack a canonical voltage
170 disease, its nuclear translocation
mechanism remains unresolved.
171 rtical synapses, but the cellular
mechanisms remain unresolved.
172 rent neurologic diseases, but the
mechanisms remain unresolved.
173 of plasticity, but the underlying
mechanisms remain unresolved.
174 of plasticity, but the underlying
mechanisms remain unresolved.
175 a in this process, but underlying
mechanisms remain unresolved.
176 tical neurons, but the underlying
mechanisms remained unresolved.
177 ne transport across the symbiosomal
membrane remains unresolved in all bacteriocyte-containing insect
178 ported role on glucose and energy
metabolism remains unresolved.
179 trate of plant and animal
methyltransferases remains unresolved.
180 lular damage from dysfunctional
mitochondria remain unresolved.
181 ology (class 2), imaging-based risk
modeling remains unresolved.
182 physical mechanisms of most such
modulations remain unresolved.
183 d why species exhibit conserved
morphologies remains unresolved.
184 ogenetic position as suggested by
morphology remains unresolved.
185 fluences the risk of postoperative
mortality remains unresolved.
186 illin-resistant Staphylococcus aureus (
MRSA)
remains unresolved.
187 a cognitive ability essential to
musicality,
remains unresolved [1-5].
188 istent neuronal encoding within this
network remain unresolved.
189 rain barrier (BBB) and induce
neuropathology remain unresolved.
190 It
nevertheless remains unresolved to what extent variable ocean heat is
191 cal mechanisms to explain these
observations remain unresolved.
192 ryonic origin of trunk denticle
odontoblasts remains unresolved.
193 or deficits in severe stroke survivors
often remain unresolved over extended time periods.
194 ate body plan, but their evolutionary
origin remains unresolved.
195 nchronous climate oscillations, whose
origin remains unresolved.
196 How plant seeds
originated remains unresolved, in part due to disconnects between f
197 anisms that determine such variable
outcomes remain unresolved.
198 ncer-relevant pathways within these
outcomes remains unresolved.
199 e preparation method and extent of
oxidation remain unresolved for catalytic applications.
200 f CB(2) from these cells in neuropathic
pain remains unresolved.
201 However, the hydrogen bonding
partnership remains unresolved.
202 FH); however, its impact on AMD
pathobiology remains unresolved.
203 I spectrin functions to neuronal
pathologies remain unresolved.
204 iences, yet to date a few important
pathways remain unresolved.
205 erable mortality rate for young HCM
patients remains unresolved.
206 ble PCP defects; thus, how Wnts regulate
PCP remains unresolved.
207 d that about one-third of the detected
peaks remained unresolved by MALDI-TOF, which led to a 3-5 tim
208 especially among those of the
Pentapetalae,
remain unresolved.
209 ction and response affects plant
performance remains unresolved.
210 between systemic bone loss and
periodontitis remains unresolved; and the trabecular bone score (TBS)
211 Yet, its internal
phylogeny remains unresolved owing to limited sampling.
212 lated microglia recruitment to Abeta
plaques remains unresolved.
213 hanisms that drive it in natural
populations remain unresolved.
214 can impact the formation of Trm
populations remains unresolved.
215 are causally related to symptom
presentation remains unresolved.
216 and the roles of Wnt ligands in this
process remain unresolved.
217 at cells require a nuclease that can
process remaining unresolved and hemi-resolved DNA junctions and
218 eural circuit mechanisms for these
processes remain unresolved.
219 required for its localization and
processing remain unresolved.
220 ersies such as use of antibiotic
prophylaxis remain unresolved.
221 ple tyrosine residues in a substrate
protein remain unresolved.
222 chanism of degradation of most host
proteins remains unresolved, and the functions of many viral prot
223 of acetylation across the parasite
proteome remains unresolved.
224 ickens were first used for economic
purposes remains unresolved.
225 rimental and theoretical efforts, the
puzzle remains unresolved.
226 es(2-5) and, to date, this critical
question remains unresolved.
227 e dynamics of bistability, a larger
question remains unresolved: how this phenomenon informs us on ge
228 After a decade of controversy, the
question remains unresolved-how do vortex flows interact with dif
229 al rather than reversible, yet this
question remains unresolved even in prototypically hierarchical m
230 ir biological function, many basic
questions remain unresolved.
231 nconventional lymphocytes, but key
questions remain unresolved in the field, including why these cell
232 , and even the very existence of lipid
rafts remain unresolved.
233 very, the mechanism of the Grignard
reaction remains unresolved.
234 mental questions central to their
reactivity remain unresolved.
235 esterase substrate specificity was
realized remained unresolved, however.
236 , and evolutionary dynamics of the SR
region remains unresolved.
237 chanisms governing activation and
regulation remain unresolved.
238 ely observed but, critically, its
regulation remains unresolved.
239 iodiversity-ecosystem function
relationships remain unresolved.
240 A few interspecific
relationships remained unresolved within the multiple-species clade be
241 affiliative, and kinship-based
relationships remains unresolved.
242 GF axis, its impact on the IGF-IR
repertoire remains unresolved.
243 which significant questions in CO2
research remain unresolved: (1) mechanisms of CO2 effects on plan
244 the mechanism(s) underpinning this
response remain unresolved.
245 t the exact nature of their respective
roles remains unresolved.
246 ury of research, how plants biosynthesize
SA remains unresolved.
247 ystem multifunctionality at landscape
scales remains unresolved.
248 evance for chronic pulmonary oxygen
sensing,
remain unresolved.
249 icities are encoded in a single DNA
sequence remains unresolved.
250 ains the magnitude of this ecosystem
service remains unresolved.
251 membrane for conversion to chemical
signals remains unresolved.
252 his activity and its functional
significance remain unresolved.
253 minant mechanism of O2 transport into
silage remains unresolved.
254 eyond a +2 oxidation state in a stable
solid remains unresolved.
255 f sexual selection as a driver of
speciation remains unresolved, not least because we lack a clear em
256 functional implications of their
specificity remain unresolved.
257 ween TEX86 and sea surface temperature (
SST)
remains unresolved: How does TEX86 predict surface tempe
258 elated to the mechanisms of conduction
still remain unresolved.
259 rs influencing reorganization patterns
still remains unresolved.
260 nderlying morphine analgesic tolerance
still remains unresolved.
261 their relevance to the electronic
structure remains unresolved.
262 Although the molecular basis of OS
structure remains unresolved, recent studies suggest that the phot
263 x regions in the genome, and their
structure remains unresolved.
264 ons in living tissue, the protein
structures remain unresolved.
265 these antigen-presenting cell (APC)
subsets remain unresolved.
266 nels, a founding member of this
superfamily,
remains unresolved.
267 lation, hematopoiesis, and tumor
suppression remains unresolved.
268 hibitory circuits in network
synchronization remains unresolved.
269 rsive behavioral states via the LC-NE
system remain unresolved.
270 ts and misfolded proteins by mechanisms
that remain unresolved.
271 central nervous system raise questions
that remain unresolved, in part due to the absence of precise
272 Among those
that remain unresolved are the existence of an inactivated in
273 from vesicles by a retention mechanism
that remains unresolved.
274 homeostasis is a long-standing problem
that remains unresolved, especially in multicellular organism
275 ents are known, the relationships among
them remain unresolved.
276 the utility of surgery and radiation
therapy remains unresolved.
277 The mechanisms governing
this remain unresolved.
278 s patients but the extent and nature of
this remains unresolved.
279 they are being impacted by threats, yet
this remains unresolved across most of Earth.
280 ormation above this characteristic
threshold remains unresolved.
281 ary timescales-and whether any survive
today-
remain unresolved.
282 r, the specific function of its cognate
ToxS remains unresolved.
283 diversity of MTOR-regulated mRNA
translation remains unresolved.
284 prioritized to address cholera
transmission remains unresolved.
285 these variants affect mammary
tumorigenesis remain unresolved.
286 regarding the dynamics of quantum
tunnelling remain unresolved.
287 gy with roots, shoots, or neither of the
two remains unresolved.
288 o UTI and its role in protection against
UTI remain unresolved.
289 basis of others, such as xylose
utilization,
remains unresolved.
290 The significance of one
variant remains unresolved.
291 echanisms contributing to lifespan
variation remain unresolved.
292 the molecular consequences of this
variation remained unresolved.
293 ive breeding relates to ecological
variation remains unresolved.
294 hapes granule cell sensory responses in
vivo remains unresolved.
295 ificance of increased pHi for cancer in
vivo remains unresolved.
296 y and sensory information processing in
vivo remains unresolved.
297 oss for driving climate change under
warming remains unresolved.
298 espiration responses to soil moisture,
which remain unresolved in ecosystem models.
299 erase (PPIase) domains, the role(s) of
which remain unresolved.
300 the typical astringency of Plavac mali
wine remained unresolved.