ライフサイエンスコーパス: renew

1 ed, coupled with the loss of ability to self-renew.

2 mbryonic NMPs, these progenitors do not self-renew.

3 G resulted in ISC loss; stem cells failed to renew.

4 ot innervated but retain the ability to self-renew.

5 into diverse T cell subsets while also self-renewing.

6 is the capacity of a progenitor cell to self-renew, a key attribute that defines stem cells.

7 -like cells with highly tumorigenic and self-renewing abilities, which were selected from tumor cells

8 However, the evidence that IRTs indeed renew adaptive immune cell repertoires and rebuild a hea

9 ary and sufficient for the formation of self-renewing adult pancreatic organoids in an Aldh1b1-depend

10 directed differentiation of hPSCs into self-renewing AEC2-like cells that can be maintained for up t

11 The adult Hydra polyp continually renews all of its cells using three separate stem cell p

12 G12D/+)p53(-/-) MEPs are transformed to self-renewing AML-initiating cells and are capable of inducin

13 and somatic follicle stem cells maintain and renew an organ.

14 s) are tumour initiating cells that can self-renew and are highly tumorigenic and chemoresistant.

15 olar macrophages (APhi) are long-lived, self-renew and critical to the health impact of inhalational

16 Stem cells with the capability to self-renew and differentiate into multiple cell derivatives p

17 cells (SSCs) have the dual capacity to self-renew and differentiate into progenitor spermatogonia th

18 s, which is dependent on the ability to self-renew and differentiation.

19 Hematopoietic stem cells (HSCs) self-renew and generate all blood cells.

20 the ventricles of the embryonic brain, self-renew and generate basal progenitors(1) that delaminate

21 and only rarely enter the cell cycle to self-renew and generate neuronal or glial progenies.

22 an also acquire stem cell properties to self-renew and give rise to new tumors through the EMT.

23 nuous stream of skilled trainees in order to renew and grow.

24 r stem cells (CSCs) have the ability to self-renew and induce drug resistance and recurrence in color

25 stem cell populations that continuously self-renew and prevent aging in Hydra vulgaris However, sexua

26 Stem cells self-renew and produce progenitors with limited proliferative

27 als that activate dormant stem cells to self-renew and regenerate odor-detecting neurons and other ol

28 absorbed by the air (direct air capture) to renew and sustain the carbonate electrolyte.

29 owed with the stem cell-like ability to self-renew and the multipotent capacity to reconstitute the e

30 f stem cells - notably their ability to self-renew and to differentiate - have meant that they have t

31 The organic membrane is automatically renewed and disposed of in every analytical cycle, thus

32 With a renewed and growing interest in therapeutic oligonucleot

33 controls gene expression programmes in self-renewing and differentiating embryonic stem cells.

34 squamous cell carcinoma (SCC) growth by self-renewing and differentiating into supra-basal SCC cells,

35 in-dependent transcriptional programs in the renewing and differentiating populations of the nephron

36 intestinal crypts, we discuss here how self-renewing and other tissues execute homeostatic and injur

37 more differentiated cellular state to a self-renewing and strongly tumorigenic state, expressing NANO

38 ntroacinar cells are largely quiescent, self-renew, and, as shown by genetic lineage tracing, contrib

39 ntain a small subset of drug-resisting, self-renewing, and highly metastatic cells called tumor initi

40 member of the British royal family(18); and renewed anti-western hate in the 2019 post-ISIS landscap

41 least renewable cells in the human body, CMs renew approximately 1% annually.

42 nce of neurocompetent stem cells, which self-renew as well as generating all of the cell types found

43 50 d, and taste buds (TBs) are continuously renewed as in mammals.

44 dditional studies to provide appropriate and renewed assessments of the risks of feeding modes for th

45 The current opioid crisis has brought renewed attention and scrutiny to opioid prescriptions.

46 senting this case, the authors hope to bring renewed attention to this phenomenon among clinicians, a

47 s to guide targeted interventions has gained renewed attention, but the feasibility and utility of su

48 e host response to biomaterials has received renewed attention.

49 Molecular mechanisms preventing self-renewing brain stem cells from oncogenic transformation

50 JZ stem cells tend to self-renew by planar symmetric divisions, respond to masticat

51 ars of mass technological unemployment and a renewed call for policy efforts to address the consequen

52 optimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protect

53 Elimination of self-renewing cancer stem cells (CSCs) is necessary to perman

54 Utilizing multipotent and self-renewing capabilities, hematopoietic stem cells (HSCs) c

55 edited clones preserve multilineage and self-renewing capacity.

56 st, the function of pioneer activity in self-renewing cell divisions and across the cell cycle is poo

57 ut promotes LSC expansion by increasing self-renewing cell divisions, possibly through enhanced Ezh2

58 g a developmental trajectory identified self-renewing cells and genes required for hair cell differen

59 r RNAs (tRNA), we further discover that self-renewing cells optimize translation of codons that depen

60 identify therapeutic vulnerabilities in self-renewing cells.

61 an antibody-drug conjugate to eliminate self-renewing cells.

62 We call for renewed clarity in the varied purposes that motivate the

63 s from later divisions in the DLN could self-renew, clonally yielding a TCF1-silenced daughter cell a

64 these antibodies can be used to isolate self-renewing colorectal CICs, and that the integrin alpha7 a

65 Although the Flint, Michigan, water crisis renewed concerns about lead (Pb) in city drinking water,

66 Klf4 expression, thereby enriching the self-renewing CSC population.

67 ls (CSC) maintain both undifferentiated self-renewing CSCs and differentiated, non-self-renewing non-

68 In contrast, the small subpopulation of self-renewing CSCs exhibits an AR-negative (AR(-)) signature.

69 t hTSC derivation, but give rise to non-self-renewing cytotrophoblasts in response to BMP4.

70 o precisely define cell identity, leading to renewed debate surrounding this concept.

71 n the subject of a long-running and recently renewed debate, but little work has sought to understand

72 s) have features such as the ability to self-renew, differentiate into defined progenies and initiate

73 me enabling further transmission and causing renewed disease.

74 rs presenting a fixed fate imbalance of self-renewing divisions with an ever-decreasing proliferation

75 hin tumors that maintain the ability to self-renew, drive tumor growth, and contribute to therapeutic

76 Interest in the CBC has recently renewed due to its participation in RNA-fate decisions v

77 the metallic states of the nanoparticles are renewed during the heat treatment through reduction.

78 ell fate and division properties in the self-renewing early lineage.

79 rent management of TV infection and requires renewed education campaigns and increased surveillance.

80 in Zea mays have been limited, and warrant a renewed effort aided by molecular breeding approaches.

81 The postpandemic years will require renewed effort and focus on vision advocacy and expandin

82 We suggest that a renewed effort be made into understanding whether basal

83 egative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery.

84 n studies that provide a clear rationale for renewed efforts to develop a CD8(+) T cell-based HIV vac

85 Renewed efforts to eliminate malaria have highlighted th

86 entity in the revised WHO classification has renewed efforts to improve the recognition and managemen

87 lts of our study also highlight the need for renewed efforts to reduce exposure to the kidney cancer

88 Renewed efforts towards greater understanding of the bur

89 Self-renewing embryonic stem cells (ESCs) respond to environm

90 YAP is expressed in self-renewing embryonic stem cells (ESCs), although it is sti

91 e was first used by Gordon Guyatt in 1991, a renewed emphasis on methodology, transparent trial desig

92 Renewed emphasis on these topics is needed in order to d

93 ow cancer cells rewire metabolic pathways to renew energy sources and "building blocks" that sustain

94 ain-transcendent neutralizing antibodies has renewed enthusiasm for the possibility of preventing dis

95 nts treated with these drugs, have sparked a renewed enthusiasm in the study of KRAS and its therapeu

96 asis but potentially also that of other self-renewing epithelia.

97 utic antimalarials are needed to support the renewed eradication agenda.

98 These findings provide a rationale for renewed examination of regional astrocytes and their rol

99 es and directions, the field is experiencing renewed excitement that mutant RAS may finally be conque

100 asis of adaptive behavior could benefit from renewed experimental and theoretical investigation of mo

101 Together, these data represent a unique and renewed extensive, multidecadal historical baseline, cri

102 A reminder can temporarily renew flexibility of consolidated memories, referred to

103 We advocate that programs place a renewed focus on asking good study questions and followi

104 We advocate that programs place a renewed focus on asking good study questions and followi

105 e epidemic in high-burden settings without a renewed focus on expanding preventive measures.

106 ex, poorly defined disease; it also brings a renewed focus on ICL that will likely result in improved

107 ngthening of its epistemic foundations and a renewed focus on more practical policy problems.

108 are at particularly high risk and require a renewed focus on postresuscitation care.

109 e global COVID-19 pandemic has resulted in a renewed focus on the importance of personal protective e

110 Most proliferate (self-renew) following injury, and some migrate into the injur

111 n (<=25 mg) is automatically disposed of and renewed for every individual fraction on account of the

112 3alpha/beta and Mek1/2 (2i) instructs a self-renewing ground state whose endogenous inducers are unkn

113 exception was a significant trend change to renewed growth of CT imaging among commercially insured

114 ld) histones are segregated towards the self-renewing GSC whereas newly synthesized (new) histones ar

115 Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the

116 These renewed hair cells arise from the proliferation of surro

117 the molecular mechanisms by which PCFUs self-renew have remained largely unknown.

118 rain tumor and contains a population of self-renewing, highly tumorigenic glioma stem cells (GSCs), w

119 Self-renewing, highly tumorigenic glioma-initiating cells (GI

120 With this new understanding has emerged renewed hope for engineering these assembly lines to pro

121 Some new developments raise renewed hope for neuroprotection: the appearance of new

122 n immunotherapies and gene therapies provide renewed hope in advancing efforts toward a sterilizing o

123 ticated immunomodulatory therapies has given renewed hope to many patients, but notable challenges re

124 a mechanism for the maintenance of the self-renewing HSC state.

125 Cdc42 activity, resulting in increased self-renewing HSC with competitive reconstitution advantages.

126 e produced in multilineage-repopulating self-renewing human HSCs with high frequency as assayed in pr

127 the discovery of P. ramorum in Asia provide renewed impetus for research on the sudden oak death pat

128 Thermally responsive gels are easier to renew in the capillary as they can be repetitively switc

129 pulations develop during embryogenesis, self-renew in the steady state and expand during type 2 immun

130 ed in culture can produce myofibers and self-renew in vitro and in vivo Together, we demonstrate that

131 CoFAR was renewed in 2010 for an additional 5-year period during w

132 membranes in the renal cortex are constantly renewed in an ordered fashion.

133 ustain effector T-cell production while self-renewing in reaction to persistent antigen; yet, excessi

134 stabilize the landforms and may even promote renewed incision.

135 mESCs can self-renew indefinitely in vitro.

136 pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for

137 B-1a cells are long-lived, self-renewing innate-like B cells that predominantly inhabit

138 l features of patients with SA, which should renew interest in deciphering the interactions between i

139 Recent studies mainly in Arabidopsis have renewed interest and discussion in some of the key issue

140 In recent years, lignin has attracted renewed interest as a feedstock for bio-based chemicals

141 ly termed "Ly-1" and now "B-1," has received renewed interest as an innate-like B cell population of

142 Yarn supercapacitors have attracted renewed interest as promising energy storage for wearabl

143 ppointing results in practice but are now of renewed interest due to improved machine-learning strate

144 energy conversion has attracted substantial renewed interest due to its applications in industrial h

145 e Sabatier reaction, a chemical process with renewed interest for storing surplus renewable energy in

146 predators of bacteria, phages have garnered renewed interest for their use as antimicrobial agents,

147 This renewed interest has spurred the refinement of existing

148 ially protective against gonorrhea, this has renewed interest in a gonococcal vaccine, and several ca

149 drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as

150 as most underestimated in the context of AD, renewed interest in cerebellar lesions has recently aris

151 While recent studies have sparked renewed interest in colour processing in Drosophila, pho

152 This period has coincided with renewed interest in developing effective interventions,

153 There has been renewed interest in environmental releases of engineered

154 In recent years, a renewed interest in fundamental aspects of solute-solven

155 ling and extracting techniques have led to a renewed interest in historic oil and gas fields, but lim

156 348 348 References 348 There is renewed interest in how transgenerational environmental

157 ts from more recent trials have stimulated a renewed interest in hypofractionation, and the noninferi

158 olerated than previous generations, spawning renewed interest in identifying selective ligands that e

159 The advent of biosimilars has sparked a renewed interest in immunogenicity that has resulted in

160 on peaks, we argue that the time is ripe for renewed interest in inmate society and its connections t

161 n, given the availability of ruxolitinib and renewed interest in interferons.

162 develop new treatment strategies, there is a renewed interest in investigating the neurobiological ba

163 e distinct clinical concerns have stimulated renewed interest in K. pneumoniae research and particula

164 This triggered renewed interest in lower-dimensional hybrid halide pero

165 Recently, a renewed interest in mechanically controlled polymerizati

166 be following similar trends as DENV and have renewed interest in monitoring and modeling arboviruses

167 lted in an urgent need for new therapies and renewed interest in other classes such as aminocyclitols

168 Recent studies have sparked a renewed interest in phase variation mediated through DNA

169 (ICIs) into cancer treatment algorithms has renewed interest in PNSs.

170 has been extensively studied, there has been renewed interest in RAGE for its potential role in sepsi

171 eveloped over the last century have received renewed interest in recent years from the development of

172 with its biological substrates, motivating a renewed interest in rethinking our approach to diagnosin

173 advances in telomerase biology has led to a renewed interest in targeting this enzyme.

174 ly studied in rats instead of mice, there is renewed interest in the anatomy of the mouse autonomic n

175 in patients with multiple sclerosis (MS) has renewed interest in the antibody-independent pathogenic

176 unds during the last decade has engendered a renewed interest in the chemistry of these species.

177 e archeological times; currently, there is a renewed interest in the direct use of the acorns as nuts

178 cal and clinical sciences are experiencing a renewed interest in the fact that males and females diff

179 hout the last half century, it has enjoyed a renewed interest in the last 15 years since Crick and Ko

180 experimental clinical contexts has triggered renewed interest in the mechanism of action of psychedel

181 new, its rise to preeminence has resulted in renewed interest in the mechanisms that shape and drive

182 ll-optical helicity dependent switching, has renewed interest in the physics that governs the interac

183 cellent potency and selectivity have sparked renewed interest in the selective targeting of SHP2 and

184 development of novel oral anticoagulants has renewed interest in the use of anticoagulation to preven

185 Over the past decade, there has been a renewed interest in the use of transition metal polypyri

186 In summary, a renewed interest in the use of ultra-short columns is wa

187 erogeneity of macrophage subpopulations have renewed interest in their functional diversity in homeos

188 With renewed interest in therapy with alpha-particle emitters

189 Despite the renewed interest in this ancient organelle of growing bi

190 Renewed interest in this area has begun to showcase the

191 Recent renewed interest in using fossil data to understand how

192 binoid production for medicinal purposes has renewed interest in utilizing byproducts of industrial h

193 There is renewed interest in utilizing viruses of bacteria known

194 adowed by chemical antibiotics, is garnering renewed interest in Western medicine.

195 scovery of extortion and generous strategies renewed interest on the role of strategy in shaping beha

196 , and altered tumor metabolism has witnessed renewed interest over the past decade, including the stu

197 Clostridium acetobutylicum has received renewed interest worldwide as a promising producer of bi

198 These cells have recently sparked renewed interest, facilitated through the development of

199 losis transmission is now being studied with renewed interest.

200 ecules for specific venom toxins have gained renewed interest.

201 Recently, there have been renewed interests in exploring new catalysts for ammonia

202 We anticipate that our results will spark renewed investigation in modulating the function of thes

203 e development of aortic aneurysms has led to renewed investigations into the role of TGF-beta biology

204 t inducing endogenous cardiomyocytes to self-renew is an exciting and promising therapeutic strategy

205 ith the aim of allowing the immune system to renew itself.

206 terminally differentiated effector cells and renews itself for continued defense.

207 and 1200 as drier conditions coincided with renewed land clearance, the establishment of a permanent

208 eir myeloid differentiation, generating self-renewing leukemic stem cells (LSCs).

209 ydroxybutyrate (betaOHB), distinguishes self-renewing Lgr5(+) stem cells (ISCs) from differentiated c

210 from its membrane receptor target to enable renewed ligand sequestration.

211 ed that ductal cells clonally expand as self-renewing liver organoids that retain their differentiati

212 These results fuel a renewed look at neurobiological accounts of selection-in

213 s cancer growth is driven by subsets of self-renewing malignant cells.

214 these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own.

215 The potential to renew morphogenesis is reexposed when the field is reduc

216 In the human hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells

217 ion supports rosette-like stem cells, a self-renewing naive-primed intermediate.

218 f-renewing CSCs and differentiated, non-self-renewing non-CSCs through cellular division.

219 Thus, we here identify long-term self-renewing NSCs that contribute to the generation of new n

220 offer researchers studying complex diseases renewed opportunities to discover new or repurpose exist

221 The capacity of stem cells to self-renew or differentiate has been attributed to distinct m

222 rpendicular to the basement membrane to self-renew or produce differentiated stratified layers, but t

223 basal cells, including the capacity to self-renew or undergo multi-lineage differentiation in vitro

224 er analysis, and the involved processes need renewed organization; however, the origin is known, and

225 They also profoundly renew our understanding of Humboldt's scientific thinkin

226 d development of donor-specific antibody has renewed our interest in subclinical alloreactivity.

227 stem-like cells that are totipotent and self-renew over the long term, 2) Ascl1(+) transit-amplifying

228 The live observations give renewed perspective on the mechanisms of axonal guidance

229 Recent years have seen renewed policy interest in urban cycling due to the nega

230 Renewed political will, coupled with improved access to

231 these cells represent a proliferative, self-renewing population capable of differentiating to STs an

232 lopment, after which Tregs persist as a self-renewing population that regulates immune system activat

233 aberrant differentiation and diminished self-renewing potential of the basal compartment, which harbo

234 ) are slower cycling and have decreased self-renewing potential.

235 y resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeosta

236 sed policy solution since 1990, is receiving renewed press attention and popular support.

237 The differentiation of self-renewing progenitor cells requires not only the regulati

238 tion of self-renewal potential in a non-self-renewing progenitor compartment.

239 Regulation of the pool of self-renewing progenitors involves the hedgehog and mammalian

240 ong-lived basal cell population able to self-renew, proliferate, and generate differentiated cells, c

241 reprogramming of the adult inner ear induces renewed proliferation and regeneration of inner ear cell

242 tudies and early phase clinical trials offer renewed promise for immunologic strategies for blocking

243 ed dedifferentiation and acquisition of self-renewing properties.

244 Revaccination may renew protection.

245 e that this paper serves as a catalyst for a renewed research agenda into interventions that support

246 en drought stress is relieved, likely due to renewed selection by the host.

247 t their differentiating progeny receive self-renewing signals.

248 ndifferentiated cells from a GFRalpha1+ self-renewing state to the NGN3 + transit-amplifying compartm

249 metric cell division (ACD) to produce a self-renewed stem cell and a differentiating daughter cell.

250 ndergo asymmetric division to produce a self-renewing stem cell and a differentiating daughter cell.

251 gous centrosome asymmetries featured in self-renewing stem cell divisions.

252 signaling) are a faster-cycling, highly self-renewing stem cell pool.

253 In plants and animals, self-renewing stem cell populations play fundamental roles in

254 ersus daughter centrosomes, whereby the self-renewing stem cell selectively inherits the mother or da

255 ence of WNT10A, and identify Wnt-active self-renewing stem cells in affected tissues including hair f

256 amage, forming new myofibers along with self-renewing stem cells in preparation for subsequent injury

257 In seed plants, self-renewing stem cells located in the shoot apical meristem

258 rogenic niche in the crayfish DPS lacks self-renewing stem cells, its cell pool being instead sustain

259 demic became an imperative for mobilization, renewed strategies for vector control, and biomedical re

260 on of molecular classification are providing renewed support for the paradigm that antibody-mediated

261 signaling could be exploited to augment self-renewing T cells in chronic infections and cancer.

262 y, notably among the subset of TCF-1(+) self-renewing T cells.

263 austed T cells that are TCF1(-) and the self-renewing TCF1(+) population from which they derive.

264 le evolution, such as tilts or dissection by renewed tectonic extension, depending on their positions

265 ing exosome in cytosolic siRNA delivery will renew the concept and interest in using FA as cancer tar

266 Adult stem cells divide to renew the stem cell pool and replenish specialized cells

267 part of an ongoing process to review and to renew the vision and direction of IDSA.

268 Several recent studies have renewed the debate concerning the role of herpesviruses,

269 tation of pharmacologic CFTR modulators have renewed the field's focus on developing gene therapies f

270 ive inhibition of factor Xa or thrombin, has renewed the interest in dual-pathway inhibition strategi

271 rsors and ground tissue stem cells divide to renew themselves and produce the vascular tissue, endode

272 cells reside outside the JZ, preferentially renew through perpendicular asymmetric divisions, and ar

273 topoiesis in the embryonic yolk sac and self-renew throughout life.

274 iest stages of skeletal development and self-renew throughout the life of the animal.

275 Many fast renewing tissues are characterized by a hierarchical cel

276 The intestinal epithelium is one the fastest renewing tissues in mammals and is endowed with extensiv

277 How adult stem cells maintain self-renewing tissues is commonly assessed by analysing clona

278 In hierarchically organized self-renewing tissues, higher levels of mtDNA were observed i

279 y quiescent but occasionally divide and self-renew to maintain the stem cell pool and to insure the c

280 Hematopoietic stem cells (HSC) self-renew to sustain stem cell pools and differentiate to ge

281 witch between Mll2 and Set1A during the self-renewing-to-differentiation transition.

282 he kidney, are metabolically active and self-renew under glycolytic conditions.

283 f p62 impaired breast cancer cells from self-renewing under anchorage-independent conditions, whereas

284 With the recent renewed understanding of glutamine metabolism involvemen

285 This renewed understanding of the foot may improve the clinic

286 This physical insight allows a renewed understanding of the role of repeating sequences

287 se cells can generate new tenocytes and self-renew upon injury.

288 t to reduce pain and further collapse and/or renew vertebral body height by introducing bone cement i

289 This calls for renewed vigilance, with systematic reference to astronom

290 flected by its potential for an unacceptably renewed viral onslaught.

291 45.6%; 6,030/13,210) but was associated with renewed viral rebound and switch.

292 ned future a link to Art, and a passage to a renewed vision of the sacred in science.

293 ned future a link to Art, and a passage to a renewed vision of the sacred in science.

294 hydrogels have the ability to grow and self-renew when placed under conditions that facilitate cell

295 preferentially differentiate instead of self-renewing when activated.

296 lo)CCR2(-) resident cardiac macrophages self-renew with negligible blood monocyte input.

297 The outer segment is constantly renewed with new discs added at its base every day.

298 ere, we examined how ILCs are maintained and renewed within tissues.

299 In the CNS, microglia self-renew without input from blood monocytes.

300 ould not be one of the major drivers for the renewed XCH(4) growth, thus other sources and sinks shou