ライフサイエンスコーパス: renewal

1 r Bmi-1 expression (marker of stem cell self-renewal).

2 and greater intestinal stem cell (ISC) self-renewal.

3 differentiation and increased malignant self-renewal.

4 hat restores intraocular pressure and medium renewal.

5 of epidermal differentiation, function, and renewal.

6 ical for understanding organ development and renewal.

7 assembly factor CAL1, drives stem cell self-renewal.

8 t to drive HSC quiescence and long-term self-renewal.

9 ISCs proliferation and intestinal epithelial renewal.

10 s by regulating breast cancer stem cell self-renewal.

11 including proliferation, apoptosis, and self-renewal.

12 role in breast cancer stem cell (BCSC) self-renewal.

13 elease into the intestinal lumen and on cell renewal.

14 tiple target genes related to stem cell self-renewal.

15 eloid progenitor cell proliferation and self-renewal.

16 late morphogenesis, cell fate, and stem cell renewal.

17 ebrates and persists throughout life without renewal.

18 d the 3D format were important for HSPC self-renewal.

19 es involved in cell differentiation and self-renewal.

20 promoted differentiation, and repressed self-renewal.

21 alveolar differentiation and decreased self-renewal.

22 in directing cellular fate specification and renewal.

23 from LGN binding, thereby favoring TIC self-renewal.

24 ing embryonic morphogenesis and adult tissue renewal.

25 follicles, sebaceous glands and/or epidermis renewal.

26 al roles in postnatal tissue maintenance and renewal.

27 signaling gradient necessary for tissue self-renewal.

28 ession of HOX genes, critical for their self-renewal.

29 r memory expression and promoted spontaneous renewal 14 days after extinction.

30 lts in loss of nephron progenitor cell (NPC) renewal, a phenotype opposite to WT.

31 als a molecular framework that explains self-renewal, aberrant differentiation, and SCC growth in mic

32 protein stability supports cancer cell self-renewal abilities in both in vitro and in vivo settings.

33 er cells can be selectively deprived of self-renewal ability by interfering with their epigenetic sta

34 s are following suit, harnessing iPSCs' self-renewal ability to manufacture cell therapies that don't

35 ristics, trophic activity, high invitro self-renewal ability, and can be readily engineered to enhanc

36 ces a loss of HSC quiescence, symmetric self-renewal ability, and renders HSC more vulnerable to seri

37 ction of TAZ protein levels and loss of self-renewal ability, which could be reversed by overexpressi

38 scue of TEAD4 expression restores their self-renewal ability.

39 ve form of RUNX1, resulting in enhanced self-renewal activity in hematopoietic stem/progenitor cells.

40 xpansion by creating a transient bias in the renewal activity of epidermal stem cells, while a second

41 utations of these motifs abrogate LST-1 self-renewal activity.

42 liferative therapies may fail to target self-renewal, allowing for relapse.

43 stemnness markers, sphere formation and self-renewal, along with growth of tumors and established exp

44 lators of hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target.

45 environment with specific features of tissue renewal and a receptive endometrium.

46 adiotherapy response by inhibiting BCSC self-renewal and associated pluripotency.

47 regulators YAP1 and TAZ are central for cell renewal and cancer growth; however, the specific downstr

48 oscillations, recognizing that zG layer self-renewal and cell heterogeneity may complicate this task.

49 pidermal stem cells (ESCs) that balance self-renewal and cell-fate decisions to establish a protectiv

50 ar niche regulating balance between HSC self-renewal and commitment.

51 Low-dose iAs increased self-renewal and decreased differentiation of human PrSPCs by

52 cal malignancy with abnormal progenitor self-renewal and defective white blood cell differentiation.

53 em cell presumed to only be forced into self-renewal and differentiation by injury.

54 ulatory factors controlling trophoblast self-renewal and differentiation have been poorly elucidated.

55 tor, SOX2, by cytokine stimuli controls self-renewal and differentiation in cells.

56 e kinetics of progenitor choice between self-renewal and differentiation in vivo is, due to the techn

57 alance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for a healthy bl

58 ise regulation of the choice between RG self-renewal and differentiation is critical for normal devel

59 The intricate balance between self-renewal and differentiation is governed by developmental

60 ), a commonly used Haspin inhibitor, on self-renewal and differentiation of mouse embryonic stem cell

61 g pathway regulates the balance between self-renewal and differentiation of SCM and CM T cells, and p

62 ng the regulatory programs that control self-renewal and differentiation of stem and progenitor cells

63 ifferentiation on the redistribution of self-renewal and differentiation probabilities also greatly i

64 tes of bronchiolar club progenitor cell self-renewal and differentiation were reduced, indicative of

65 etabolites regulate the balance between self-renewal and differentiation, but whether endogenous meta

66 cells and governing the balance between self-renewal and differentiation.

67 ncompasses the capability of a cell for self-renewal and differentiation.

68 ugh a balanced regulation of progenitor self-renewal and differentiation.

69 istal prostate luminal lineages through self-renewal and differentiation.

70 ntestinal lumen is sufficient to promote ISC renewal and drives regeneration in response to injury.

71 isms of IRTs in the context of immune system renewal and durable disease remission in MS.

72 t maintain redox balance promote T cell self-renewal and enhance anti-tumor immunity.

73 man intestinal stem cell niche supports self-renewal and epithelial function, but little is known abo

74 is to elucidate the cell types, development, renewal and evolution of the alveolar capillary endothel

75 quired for homeostatic intestinal epithelial renewal and fate specification, and for regeneration aft

76 R5 in organ development, as well as the self-renewal and fitness of adult stem cells.

77 ents showed that MSCs and ECFCs induced self-renewal and genes associated with mesenchymal-epithelial

78 H1.0, Quisinostat inhibits cancer cell self-renewal and halts tumor maintenance without affecting no

79 on, which leads to complete loss of HSC self-renewal and HSC depletion.

80 lays critical roles in cancer stem cell self-renewal and immune evasion and highlights the broad pote

81 body (OMP-131R10/rosmantuzumab) impairs self-renewal and induces differentiation in AML patient-deriv

82 proteins is known for its role in stem-cell renewal and is a negative regulator of cell differentiat

83 approach with which to interrogate HSC self-renewal and lineage commitment and, more broadly, to stu

84 age, opening perspectives for balancing self-renewal and lineage commitment.

85 nforce Notch signaling, instructing ISC self-renewal and lineage decisions.

86 ptional regulatory mechanisms to govern self-renewal and lineage-specific differentiation programs.

87 lt stem cells possess the capability of self-renewal and lineage-specific differentiation.

88 hanisms that control ESC specification, self-renewal and maintenance during different stages of the l

89 rowth and metastasis by increasing BCSC self-renewal and may serve as a novel target for chemotherapy

90 free survival, as well as enhances BCSC self-renewal and metastatic outgrowth.

91 provide evidence that APA regulates HSC self-renewal and multi-potency by affecting stem cell activat

92 enetic systems play minor roles in mESC self-renewal and naive ground state establishment by core set

93 progenitor cells (NPCs), Ybx1 controls self-renewal and neuronal differentiation.

94 s a model whereby alpha-cells expand by self-renewal and not via specialized progenitors.

95 Renewal and patterning of the intestinal epithelium is c

96 ophagy flux to maintain epithelial stem cell renewal and prevent aging.

97 The niche controls stem cell self-renewal and progenitor differentiation for maintaining a

98 single-cell level and demonstrate that self-renewal and proliferation are distinct in AML.

99 that the transcriptional foundations of self-renewal and proliferation are distinct in LSCs as they o

100 Self-renewal and proliferation are separate functions in norm

101 in the crypt Osx+ cells is critical for self-renewal and proliferation.

102 activates KLF4 in progenitors to reduce self-renewal and promote PC fate, whereas AMPK-PGC1alpha acti

103 ASPN loss impaired MSC self-renewal and promoted terminal cell differentiation.

104 VP(PV) neurons control relapse during both renewal and reacquisition via projections to VTA.

105 V) neurons contribute to relapse during both renewal and reacquisition via projections to VTA.

106 cardiomyocytes and how this might relate to renewal and regeneration.

107 nexpected and decisive role in the permanent renewal and reorganization of epithelia, which forms or

108 the immune response and precedes the tissue renewal and repair responses that are initiated by innat

109 on monocyte/macrophage differentiation, self-renewal and repairing ability, as evidenced by the downr

110 in these communities linked to dysregulated renewal and replenishment of intestinal epithelial cells

111 attenuate leukemia stem/initiating cell self-renewal and reprogram immune response by suppressing exp

112 cer stem cells possess the capacity for self-renewal and resistance to chemotherapy.

113 ch effects are long lasting and resistant to renewal and spontaneous recovery.

114 mouse and human embryos by controlling self-renewal and stemness of trophoblast progenitors within t

115 been demonstrated to regulate mouse HSC self-renewal and stemness, we screened small molecules target

116 compartmentalized to control stem cell self-renewal and stepwise progeny differentiation.

117 which is characterized by the aberrant self-renewal and subsequent oncogenic transformation of immat

118 eostasis in vitro, leading to increased self-renewal and suppressed differentiation.

119 operties of adult tissue stem cells are self-renewal and the ability to generate diverse resident cel

120 ment for Ldb1 in Lmo2-induced thymocyte self-renewal and thymocyte radiation resistance and for the t

121 elial cells (TECs) use LXRalphabeta for self-renewal and thymocytes for negative selection.

122 y active isoform of MBNL1 inhibited GSC self-renewal and tumor initiation in orthotopic transplantati

123 brogate their stem-ness, as measured by self-renewal and tumorigencity.

124 glycerol lipase (MAGL), to regulate the self-renewal and tumorigenicity of GSCs through production of

125 at only CD69(High) LSCs were capable of self-renewal and were poorly proliferative.

126 uced reconstitution potential, impaired self-renewal, and a proinflammatory phenotype.

127 of cell proliferation, differentiation, self-renewal, and epithelial-mesenchymal transition.

128 FAO supports ISC renewal, and HNF4 transcription factors directly activat

129 se that regulate the cycle, metabolism, self-renewal, and immune cell signaling.

130 lted in de-repression of IHH, decreased self-renewal, and increased sensitivity to chemotherapy in vi

131 Skin undergoes constant self-renewal, and its functional decline is a visible consequ

132 acetylase, in driving RMS tumor growth, self-renewal, and migration/invasion.

133 s to impaired differentiation, enhanced self-renewal, and proliferation of immature myeloid cells.

134 ctivity profiles during self-administration, renewal, and reacquisition.

135 udied the role of BAs and TGR5 in intestinal renewal, and regulation of ISC function in mice and inte

136 to cell division during development, growth, renewal, and repair.

137 s CD44, Nanog, Sox2, and OCT4 leading to CSC renewal, and TGLI1 outcompetes with GLI1 for binding to

138 ed stem cells requires Wnt proteins for self-renewal, and this subset specifically relies on Wnt/beta

139 lase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo regardless of disease

140 investigated whether proliferation and self-renewal are separate functions in LSCs as they often are

141 erized a top hit from the screen, progenitor renewal associated non-coding RNA (PRANCR), using RNA in

142 Tissue renewal becomes compromised with age.

143 DOT1L is dispensable for ESC self-renewal but is required for establishing the proper expr

144 ntribute to contextual control over relapse (renewal), but not to relapse during reacquisition, via p

145 n that Wnt plays a priming role for ISC self-renewal by inducing RSPO receptor LGR5 expression.

146 rts photoreceptors and participates in their renewal by phagocytosis of the tips of the photoreceptor

147 ckpoint that governs HSC quiescence and self-renewal by Rheb-mediated restriction of mTOR activity.

148 We found that this self-renewal can be reversed by oral administration of a smal

149 on of archetypal hPSC enriched for high self-renewal capacity (ESR) has distinct properties relative

150 Targeting MUC1-C decreases PC self-renewal capacity and tumorigenicity, suggesting a potent

151 es adult prostate stem/progenitor cells self-renewal capacity in both organoid and allograft assays.

152 ll differentiation potential along with self-renewal capacity is a major property of pluripotent stem

153 in basal cells as shown by the impaired self-renewal capacity of Bmp5-deficient stem/progenitor cells

154 and PAF1 to the Nanog promoter, and the self-renewal capacity of CSCs, were decreased in cells incuba

155 r potency to inhibit cell viability and self-renewal capacity of FGbeta(3) cells.

156 d expression of miR-486-5p enhanced the self-renewal capacity of GBM neurospheres, and inhibition of

157 The self-renewal capacity of multipotent haematopoietic stem cell

158 phere formation, indicating compromised self-renewal capacity.

159 a stable phenotype and nearly limitless self-renewal capacity.

160 xhausted phenotype, marked by a loss of self-renewal capacity.

161 ukemia stem cells (LSC), the cells with self-renewal capacity.

162 , relapse and metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of th

163 in two forms of relapse to alcohol-seeking: renewal (context-induced reinstatement) and reacquisitio

164 uring relapse to alcohol-seeking provoked by renewal (context-induced reinstatement), we found that V

165 The HSC self-renewal defect is rescued after cell transplantation int

166 onfirmed its role in regulating TAZ and self-renewal, demonstrating the potential utility of targetin

167 class of cancer cells characterized by self-renewal, differentiation and tumorigenic potential.

168 d requires a controlled balance between self-renewal, differentiation, and quiescence.

169 ancing forebrain-hindbrain lineages and self-renewal-differentiation choices in NPCs.

170 ent, suggesting a common rule governing self-renewal/differentiation behaviors in mouse cortical prog

171 omolecule shown to control SC symmetric self-renewal divisions via the noncanonical WNT/planar cell p

172 s not affect the mode or the outcome of self-renewal divisions.

173 sociated with planar-oriented symmetric self-renewal divisions.

174 nderlying the spatiotemporal control of self-renewal during skeletal muscle repair.

175 9 time points over 5 broad conditions: self-renewal, early neuronal differentiation, neural precurso

176 Self-renewal epidermoid epithelia are continuously exposed to

177 4(+), CD133(+), and ALDH(hi) cells) HSC self-renewal ex vivo.

178 reactive stem-like TILs were capable of self-renewal, expansion, persistence, and superior antitumor

179 tes gene expression programs to control self-renewal for the maintenance of mESC state.

180 l-cycle gene expression and increase in self-renewal gene expression are coregulated by SOX2 and EZH2

181 /Tead complex as a key regulator of the self-renewal gene network in organ of Corti progenitor cells.

182 ings define and functionally validate a self-renewal gene profile of leukemia stem cells at the singl

183 ing pathway, RSPO-LGR4, upregulates key self-renewal genes and is essential for LSC self-renewal in a

184 criptional regulation of cell-cycle and self-renewal genes is orchestrated during these conversions r

185 yonic fetal liver, the mechanism of HSC self-renewal has remained elusive.

186 -renewal genes and is essential for LSC self-renewal in a subset of AML.

187 exes which normally function to enforce self-renewal in bone marrow hematopoietic progenitors.

188 essive factor that inhibits cancer cell self-renewal in many cancer types, can be broadly induced by

189 ation with the Collaborative for Healing and Renewal in Medicine (CHARM) network, the authors gathere

190 rving LSC quiescence, and promoting LSC self-renewal in MLL-rearranged AML.

191 to undergo differentiation and loss of self-renewal in response to inflammation.

192 s of TEAD4 is associated with defective self-renewal in RPL-TSCs and rescue of TEAD4 expression resto

193 ich IGF1 together with Activin maintain self-renewal in the absence of fibroblast growth factor (FGF)

194 of Gli1-targeted NSCs showing long-term self-renewal in the adult hippocampus.

195 l drivers of hematopoietic survival and self-renewal in the bone marrow niche; how to apply this proc

196 Signals driving aberrant self-renewal in the heterogeneous leukemia stem cell (LSC) po

197 gests that DRD2 is capable of promoting self-renewal in these cell lines, but that it is not active.

198 lls derived from EpiSCs exhibit limited self-renewal in vitro and a gene expression signature like th

199 esents our current understanding of HSC self-renewal in vivo and ex vivo, and discusses important adv

200 of Bmi-1 (master regulator of stem cell self-renewal) in dental pulp stem cells.

201 that therapeutic strategies that target self-renewal, in addition to proliferation, are critical to p

202 anscriptional regulators promoting hPSC self-renewal including ZNF398, a human-specific mediator of p

203 elated to stem cell differentiation and self-renewal, including Notch, ERK/MAPK and Wnt/beta-catenin

204 ograms shifts leukemia cell fate out of self-renewal into differentiation.

205 concept that targeting BMI1-related CSC self-renewal is a clinically relevant anti-cancer therapy in

206 hat oncogene-induced loss of progenitor self-renewal is driven by eIF2B5-mediated translation of ubiq

207 t, however, the actual rate of cardiomyocyte renewal is too low to efficiently counteract substantial

208 timplantation mouse TSPCs impairs their self-renewal, leading to embryonic lethality before embryonic

209 naling pathways are known to control SC self-renewal, less is known about the mechanisms underlying t

210 of cell types that together direct stem cell renewal, lineage commitment, and differentiation.

211 criptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion

212 s to regulate tumor growth through cell self-renewal maintenance, and BPTF knockdown leads these glia

213 of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potent

214 ies: while under asymptotic conditions, self-renewal models of the same universality class cannot be

215 strates muscle stem cell proliferation, self-renewal, myoblast differentiation, and ultimately format

216 pleted of PAF1 downregulated markers of self-renewal (NANOG, SOX9, and beta-CATENIN), of CSCs (CD44v6

217 me course of transcriptional responses, self-renewal of APhi, and the contribution from bone marrow (

218 iabetes mellitus, the path toward endogenous renewal of beta-cell populations has remained elusive.

219 f HDAC11 not only significantly reduces self-renewal of cancer stem cells (CSCs) from NSCLC but also

220 XEN445 inhibited the self-renewal of cancer stem cells (CSCs) in vitro and TNBC tu

221 o the call by the conceivers of TTOM for the renewal of computational psychiatry.

222 rs (e.g., interleukin-6 [IL-6]) promote self-renewal of dental pulp stem cells cultured in low-attach

223 othelial cell-derived IL-6 enhances the self-renewal of dental pulp stem cells via STAT3 signaling an

224 ated signaling is necessary to maintain self-renewal of dental pulp stem cells.

225 ft, without perturbing repopulation and self-renewal of edited HSCs.

226 that is essential for pluripotency and self-renewal of embryonic stem cells(3).

227 center around response to energy crisis and renewal of energy resources via autophagy-mediated catab

228 hanisms of Hydra aging, we compared the self-renewal of epithelial stem cells in these two strains an

229 eration of beta cells provides hope for self-renewal of functional insulin-secreting cells following

230 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells.

231 7 miRNAs are essential for limiting the self-renewal of HC progenitor cells.

232 for normal differentiation, but limits self-renewal of hematopoietic stem cells (HSCs) during aging

233 carbon for climate change mitigation, but a renewal of high methane emissions has been reported for

234 isk is associated with the function and self-renewal of HSCs.

235 However, the potential for long-term self-renewal of individual NSCs within the adult brain remain

236 Self-renewal of intestinal stem cells is controlled by Wingle

237 ted, and only LGR4 is essential for the self-renewal of intestinal stem cells.

238 genes required for FAO and are required for renewal of ISCs.

239 of FAO, indicating that FAO was required for renewal of ISCs.

240 development and maintenance of AML and self-renewal of leukemia stem/initiating cells (LSCs/LICs) bu

241 of Gsk3alpha/beta and Mek1/2 to sustain self-renewal of mESCs in combination with leukaemia inhibitor

242 force, it is favorable to the transport and renewal of microorganisms and nutrients.

243 s required for survival, quiescence and self-renewal of MLL-AF9 (MA9)-transformed leukemia stem cells

244 FTO inhibited the self-renewal of ovarian CSC and suppressed tumorigenesis in v

245 the present results illustrate the permanent renewal of placenta-specific genes by retroviral capture

246 d TET2 confer an advantage by enhancing self-renewal of stem and progenitor cells and inhibiting thei

247 i1), which mediates the maintenance and self-renewal of stem cells and acts as a translational regula

248 H2B3) encode proteins that regulate the self-renewal of stem cells(14-16).

249 of these two proteins in the maintenance and renewal of stem cells.

250 tokeratin19(-) /SOX9(+) ) is involved in the renewal of surface epithelium in injured EHBT.

251 ly, NRP1 cell-intrinsically limited the self-renewal of the CD44(+)PD1(+)TCF1(+)TIM3(-) progenitor ex

252 proliferative cells that fuel the continuous renewal of the intestinal epithelium.

253 sponsive stem cells that contributed to self-renewal of the tissue.

254 consistent with their potential role in the renewal of tissue ILC2s.

255 rved molecular mechanisms that regulate self-renewal of trophoblast progenitors and their association

256 The renewal or branching process model is a popular solution

257 al model to estimate the probability of self-renewal or differentiation of cortical progenitor behavi

258 llular integrity with a reduced capacity for renewal or repair.

259 ree novel oncogenic pathways to promote self-renewal, p53 loss, and Nanog transcription in TICs.

260 lysomes and enhancing proliferative and self-renewal pathways.

261 r results showed that DON decreased the self-renewal potential and metastatic ability of tumor cells.

262 We conclude that EZH2 is required for NPC renewal potential and that tempering of the differentiat

263 is sustained by mitotic germ cells with self-renewal potential known as undifferentiated spermatogoni

264 n quiescence to sustain their long-term self-renewal potential.

265 l model based on the Cox method of modulated renewal process of spike train influence, reciprocal- an

266 e also consistent with an underlying Poisson renewal process.

267 ct probabilistic models-specifically, marked renewal processes-to evaluate how bout types and interbo

268 atopoietic precursors and promote their self-renewal, proliferation, and differentiation.

269 tion of stem cell quiescence, survival, self-renewal, proliferation, senescence, and differentiation.

270 ESC cytonemes select self-renewal-promoting Wnts via crosstalk between Wnt recepto

271 entre B cells with enhanced fitness and self-renewal properties, ultimately leading to aggressive lym

272 HP1gamma-deleted ESCs have a slower self-renewal rate and an impaired ability to differentiate to

273 ted EZH2 and SOX2 during cell-cycle and self-renewal regulation to restrain tumorigenesis.

274 patterns are maintained during lineage self-renewal remain unclear.

275 ve antigenic stimulation impairs T cell self-renewal remains poorly defined.

276 are serine auxotrophs whose growth and self-renewal require abundant exogenous serine.

277 To identify strategies of stem cell self-renewal requires that different models of stem cell fate

278 networks associated with cell cycle and self-renewal.See related commentary by Pardini and Dragomir,

279 is regulated by a balance between BMP5 self-renewal signal and GATA3 dampening activity.

280 Meantime, the renewal speed of biofilms is also relatively fast.

281 suppression of ICMT results in reduced self-renewal/stemness in KRAS-driven pancreatic and breast ca

282 ical asymmetric vs. symmetric stem cell self-renewal strategies and are distinguished by a conservati

283 and opportunities to identify stem cell self-renewal strategies: while under asymptotic conditions, s

284 Poisson renewal theory provides an evolutionarily preserved univ

285 Although the SEPs are capable of self-renewal, they are erythroid restricted.

286 ged muscle regeneration by enhancing SC self-renewal through active repression of p16(Ink4a) transcri

287 t Vibrio cholerae acts to inhibit epithelial renewal through complex interactions between the type VI

288 Targeting of uncontrolled self-renewal through inhibition of stem cell-related signalin

289 stem cells (HSCs) have the capacity for self-renewal to maintain the HSCs' pool and the ability for m

290 erproliferation with loss of progenitor self-renewal to restrain aberrant growth and tumorigenesis.

291 orm switch to regulate glioma stem cell self-renewal, tumorigenicity, and progression.

292 population of cancer cells endowed with self-renewal, tumorigenicity, pluripotency, chemoresistance,

293 VP(Gad1) neurons control relapse during renewal via projections to LH.

294 itical role of Bccip in intestine epithelial renewal was verified with a Villin-CreERT2 mouse model.

295 lar Type II progenitor cell density and self-renewal were maintained per unit tissue area with aging,

296 A activity promotes embryonic stem cell self-renewal, whereas its up-regulation enhances differentiat

297 s that coordinate the rate of stem cell self-renewal with differentiation at a population level remai

298 H2-K1 cells eventually develop impaired self-renewal with features of senescence, limiting complete r

299 e to maintain stemness but must balance self-renewal with the production of daughters that leave the

300 igase FBXO32 specifically inhibits epidermal renewal without affecting overall proliferation, thus re