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1 ayered structure of mammalian orthoreovirus (reovirus).
2 riple-negative breast cancer cell killing by reovirus.
3 tion against influenza virus, norovirus, and reovirus.
4 s that bind the attachment protein sigma1 of reovirus.
5 nisms of antibody-mediated neutralization of reovirus.
6 cifically lacking IEC Ifnlr1 expression with reovirus.
7  in altering the cell attachment property of reovirus.
8 tors on microglial cells that are engaged by reovirus.
9 nction protein that serves as a receptor for reovirus.
10  serotonin antagonist, enhanced infection by reovirus.
11 tress correlate with their susceptibility to reovirus.
12 igma1 of serotype 1 (T1) and serotype 3 (T3) reoviruses.
13 ell death with faster kinetics than parental reoviruses.
14 VSV), Encephalomyocarditis virus (EMCV), and Reovirus-3 virus (Reo-3) in a STAT1-dependent manner.
15                                              Reovirus, a model system for studying the entry mechanis
16 capable of inhibiting cytotoxicity caused by reovirus, a prototype double-stranded RNA virus.
17 in humans supports a role for infection with reovirus, a seemingly innocuous virus, in triggering the
18                                              Reoviruses, a model system for entry of nonenveloped vir
19                                 Furthermore, reovirus administration in tumor-bearing hosts drives ti
20                         The effect of adding reovirus after photodynamic therapy was also assessed.
21 e intestine, intestinal epithelial cells for reovirus and intestinal mononuclear phagocytes for MNV.
22  Chinook salmon revealed a novel arenavirus, reovirus and nidovirus.
23 nation of a genetically engineered oncolytic reovirus and topoisomerase inhibitors may provide a pote
24 ted the classification of KARYV and KUNDV as reoviruses and identified replication morphology consist
25 rganization similar to that of homodimers of reoviruses and other dsRNA mycoviruses.
26 splay defective control of murine norovirus, reovirus, and influenza virus and therefore genocopy Ifn
27 do tick fever virus, Eyach virus, Tai Forest reovirus, and Tarumizu tick virus from the Coltivirus ge
28          In agreement with previous reports, reovirus antigen did not colocalize with GFAP in infecte
29                                              Reoviruses are double-stranded RNA viruses that infect h
30                                              Reoviruses are double-stranded RNA viruses that infect t
31                                              Reoviruses are emerging as useful infectious enteric vir
32                                              Reoviruses are important human, animal and plant pathoge
33                   Mammalian orthoreoviruses (reoviruses) are nonenveloped double-stranded RNA viruses
34                   Mammalian orthoreoviruses (reoviruses) are nonenveloped viruses implicated in human
35                   Mammalian orthoreoviruses (reoviruses) are nonenveloped viruses that replicate in c
36                                        Avian reovirus (ARV) p17 protein continuously shuttles between
37            Although we have shown that avian reovirus (ARV) p17-mediated inhibition of Akt leads to i
38 acilitate replication or production of avian reovirus (ARV); nevertheless, how ARV induces autophagy
39 ling of the ARV p17 protein.IMPORTANCE Avian reoviruses (ARVs) cause considerable economic losses in
40 binding capacity.IMPORTANCE We use mammalian reovirus as a model to study how virus infection modulat
41 dent cell death.IMPORTANCE We used mammalian reovirus as a model to study how virus infections result
42 ue will accelerate production of recombinant reoviruses as candidates to enhance therapeutic potency.
43 nfection and open new avenues for the use of reoviruses as oncolytic agents.
44  lines were less susceptible to infection by reovirus, as they exhibited significantly lower percenta
45  to mu1C, a previously described hallmark of reovirus assembly.
46                                          How reovirus attaches to host cells has been extensively cha
47 the sigma1 receptor-binding domain modulates reovirus attachment but not uncoating or transcription.
48    We determined the structure of serotype 1 reovirus attachment protein sigma1 alone and in complex
49                                          The reovirus attachment protein sigma1 binds sialylated glyc
50                                              Reovirus attachment protein sigma1 engages glycan recept
51                                              Reovirus attachment protein sigma1 is a trimeric molecul
52                                              Reovirus attachment protein sigma1 is an elongated trime
53 aradigm, in this article we demonstrate that reovirus augments tumor-associated immunosuppression imm
54 rence in cytotoxicity observed between added reovirus before or after photodynamic therapy.
55 rrent work appears to be the first report of reovirus being internalized within FLA and remaining inf
56                   Expression of NgR1 confers reovirus binding and infection of nonsusceptible cells.
57 red in murine microglial cells for efficient reovirus binding and infection.IMPORTANCE Attachment fac
58 a suggest that sigma1 length is required for reovirus binding to cells.
59                          We demonstrate that reovirus binds Nogo receptor NgR1, a leucine-rich repeat
60                                              Reovirus binds to cell surface glycans, junctional adhes
61 in regions of the brain that are targeted by reovirus but extended beyond areas of active infection.
62               Here, we generated reassortant reoviruses by forward genetics with enhanced infective a
63 each, but poliovirus, coxsackievirus B3, and reovirus can be stabilized by bacteria or bacterial poly
64 e identify that infection of host cells with reovirus can result in necroptosis.
65  highlight regions of mu1 that stabilize the reovirus capsid and demonstrate that an enhanced propens
66 rrent limitations in recovery of replicating reoviruses carrying large fluorescent protein tags, rese
67                       The killing effects of reovirus combined with PpIX-mediated photodynamic therap
68                  The cooperativity between a reovirus component and lipids reveals a distinct virus-h
69                     The capsids of mammalian reovirus contain two concentric protein shells, the core
70              We engineered and characterized reoviruses containing cysteine mutations that cross-link
71 lease and escape of transcriptionally active reovirus cores into the cytosol.
72 otype serotonin receptor agonist, diminished reovirus cytotoxicity.
73                             Diaphorina citri reovirus (DcRV) was previously identified based on metag
74 e organization represent the most simplified reovirus described to date, and phylogenetic analysis su
75  findings reveal a new region that regulates reovirus disassembly and how perturbing a metastable cap
76 rus transit to late endosomes and a delay in reovirus disassembly.
77 ns of endothelial and hematopoietic JAM-A to reovirus dissemination and pathogenesis, we generated st
78 ith GFAP in infected brains, suggesting that reovirus does not infect astrocytes.
79  cancer cells that were weakly sensitive for reovirus, either through PDH kinase (PDK) inhibitors dic
80                                              Reovirus encephalitis in mice was used as a model system
81 xx is present in Fas-expressing cells during reovirus encephalitis, suggesting a role for Daxx in Fas
82 sults in the activation of astrocytes during reovirus encephalitis.
83 nd that activated Bak is bound to p53 during reovirus encephalitis.
84 vels are increased in infected brains during reovirus encephalitis.
85    Enteric viruses, including poliovirus and reovirus, encounter a vast microbial community in the ma
86                                              Reovirus engages junctional adhesion molecule A (JAM-A)
87            We show that interactions between reovirus entry intermediates and lipid membranes devoid
88 olecular mechanisms underlying the multistep reovirus entry process are poorly understood.
89 intracellular vesicular transport systems in reovirus entry, trafficking, and egress and comment on s
90 t to determine whether IFITM3 also restricts reovirus entry.
91 etter understand cellular routes of nonlytic reovirus exit, we imaged sites of virus egress in infect
92            When ISVP formation is prevented, reovirus fails to establish a productive infection, sugg
93 reased intestinal tissue titers and enhanced reovirus fecal shedding.
94 will also expedite production of recombinant reovirus for mechanistic insights into reovirus protein
95 is study focuses on virus isolation of avian reoviruses from a tenosynovitis outbreak between Septemb
96                                          The reovirus fusion-associated small transmembrane (FAST) pr
97                                          The reovirus fusion-associated small transmembrane proteins
98  not commonly studied add variability to the reovirus genome.
99 ral factories, and there is no evidence that reovirus genomic or messenger RNAs are spliced, suggesti
100                      Ten isolates of a novel reovirus (genus Dinovernavirus) were detected by culturi
101                            The characterized reoviruses grouped in six distinct genotypic clusters (G
102                                              Reovirus has been used to dissect mechanisms of viral pa
103 , however, many oncolytic viruses, including reovirus, have been reported to overturn such immunosupp
104 nd animal health, including influenza virus, reovirus, HIV-1, human metapneumovirus, and vesicular st
105 onal flexibility modulates the efficiency of reovirus host cell attachment.IMPORTANCE Nonenveloped vi
106 nal rearrangements mediate the efficiency of reovirus host cell binding.
107 possible enhanced protection FLA may provide reoviruses, however, has not been previously described.
108 lps the understanding of the epidemiology of reoviruses in California.
109 he first evidence of recovery of replicating reoviruses in which VFs can be labeled in live cells via
110                            To understand how reovirus inclusions differ in productively and abortivel
111 ion is limited to brain regions that undergo reovirus-induced apoptosis and occurs in the cytoplasm a
112 ese data imply a regulatory role for Daxx in reovirus-induced apoptosis, depending on its location in
113  fibroblasts where NF-kappaB is required for reovirus-induced apoptosis, the mu2 ITAM is advantageous
114 on of the host cell impacts the mechanism of reovirus-induced cell death in TNBC.
115        To identify host factors required for reovirus-induced cell death, we conducted a CRISPR-knock
116 l triple-negative breast cancer cells and if reovirus-induced cytotoxicity of breast cancer cells can
117 rminants of dissemination and tropism during reovirus-induced disease.
118 uter capsid protein mu1 negatively regulates reovirus-induced necroptosis by limiting RNA synthesis.
119  depletion of PDK1, enhanced the efficacy of reovirus-induced oncolysis in vitro and in vivo.
120  mitochondrial localization of p53 regulates reovirus-induced pathogenesis in the central nervous sys
121 we define genetic determinants that regulate reovirus-induced pathology following intranasal inoculat
122                           Our data show that reovirus induces preferential differentiation of highly
123         In addition, survival is enhanced in reovirus-infected Bak(-/-) mice compared to controls, de
124 , we demonstrate that Daxx is upregulated in reovirus-infected brain tissue through a type I interfer
125                   Increased levels of p53 in reovirus-infected brains are not associated with increas
126 caspase 3 were detected in astrocytes within reovirus-infected brains, indicating that activated astr
127 ay a role in neuronal apoptosis occurring in reovirus-infected brains.
128       In addition, the ability of media from reovirus-infected BSCs to activate primary astrocytes wa
129  downstream signaling, inhibits apoptosis of reovirus-infected cells.
130                      Interestingly, MNV- and reovirus-infected mice depleted of M cells showed reduce
131     This increase occurs in the cytoplasm of reovirus-infected neurons and is associated with the act
132                                              Reovirus-infected neurons produce interferon beta (IFN-b
133  suggest that IFN-beta, likely released from reovirus-infected neurons, results in the activation of
134                               In particular, reovirus infection accentuated Warburg-like metabolic pe
135  that render microglial cells susceptible to reovirus infection and expands current understanding of
136 that p53 is activated in the brain following reovirus infection and may provide a therapeutic target
137               We found that, while vgRNA and reovirus infection both induce a similar IRF-dependent g
138 und that 5-nonyloxytryptamine (5-NT) impairs reovirus infection by altering viral transport during ce
139                                              Reovirus infection elicits production of type I interfer
140 nse to 5'pp-RNA is essential for controlling reovirus infection in cultured cells and in mice.
141                                              Reovirus infection induces an increase in the number and
142  activates DNA damage response pathways, and reovirus infection induces robust production of type III
143                                              Reovirus infection is a well-characterized experimental
144                                Concordantly, reovirus infection is ablated in primary cortical neuron
145         Astrogliosis also occurred following reovirus infection of ex vivo brain slice cultures (BSCs
146 the formation of p53/Bak complexes following reovirus infection of ex vivo brain slice cultures and r
147 itecture of sigma1 is required for efficient reovirus infection of host cells.
148 d expression on the cell surface and mediate reovirus infection of microglial cells.
149                           Here, we show that reovirus infection of the brain results in the activatio
150                                              Reovirus infection of the mouse SC was also associated w
151                                              Reovirus infection resulted in astrogliosis, as evidence
152                                              Reovirus infection results in cell death of a variety of
153                  Our study demonstrates that reovirus infection selectively blocks NF-kappaB, likely
154         Despite differences in cell tropism, reovirus infection was also reduced in M cell-depleted m
155 s infection in vivo Upon murine norovirus or reovirus infection, Ifnlr1 depletion in IECs largely rec
156 evious evidence that active NF-kappaB limits reovirus infection, we conclude that inactivating NF-kap
157 by transfected viral genomic RNA (vgRNA) and reovirus infection, we discovered that mammalian reoviru
158 olecule screen to identify host mediators of reovirus infection, we found that treatment of cells wit
159  of necroptosis also requires late stages of reovirus infection.
160 Slc35a1 as potential host genes required for reovirus infection.
161                            5-NT also blocked reovirus infection.
162  cells or primary cortical neurons abrogates reovirus infection.
163 for Daxx in Fas-mediated apoptosis following reovirus infection.
164  indicating that endogenous IFITM3 restricts reovirus infection.
165 y prodeath function for this molecule during reovirus infection.
166 ion uncoating is an essential early event in reovirus infection.
167    However, IFITM3 did not restrict entry of reovirus infectious subvirion particles (ISVPs), which d
168  inhibitors as a class of drugs that enhance reovirus infectivity and cytotoxicity of triple-negative
169                          In contrast to MNV, reovirus infects enterocytes in the intestine.
170 irus infection, we discovered that mammalian reovirus inhibits host cell innate immune signaling.
171                         Our analysis defines reovirus interactions with two neutralizing antibodies,
172 r capsid play an active role in the entry of reovirus into host cells.
173                                              Reovirus is an avirulent pathogen that elicits protectiv
174 nd kills transformed cells, and a serotype 3 reovirus is in clinical trials to assess its efficacy as
175 lowing attachment to cell surface receptors, reovirus is internalized by receptor-mediated endocytosi
176            The level of apoptosis induced by reovirus is significantly diminished in cells lacking No
177                     Mammalian orthoreovirus (reovirus) is a nonenveloped, segmented, double-stranded
178                     Mammalian orthoreovirus (reovirus) is composed of two concentric, protein shells.
179                 Using an infectious clinical reovirus isolate in coculture with three FLA, namely, Ve
180                                              Reoviruses, like many eukaryotic viruses, contain an inv
181                    Structural studies of the reovirus membrane penetration protein, mu1, predict that
182 y intracellular pathogens, such as mammalian reovirus, mimic extracellular matrix motifs to specifica
183 tly increased cytotoxic effect compared with reovirus monotherapy and photodynamic therapy (p=0.042)
184                                              Reovirus monotherapy induced cell death in the two pancr
185 ent understanding of cell entry by mammalian reovirus (MRV) virions and infectious subvirion particle
186    Studies of strain-specific differences in reovirus mucosal infection and systemic dissemination ha
187     Neurotropic viruses, including mammalian reovirus, must disseminate from an initial site of repli
188 e show that in cells infected with mammalian reovirus, NF-kappaB is inactive.
189                     While all other turreted reoviruses of known structures have at least two copies
190  this is the first in-vitro study to combine reovirus oncolytic viral therapy with PpIX-mediated phot
191 cytomegalovirus, vesicular stomatitis virus, reovirus, or adenovirus.
192                                          The reovirus outer capsid is stabilized by mu1 intratrimer,
193                       Proteins that form the reovirus outer capsid play an active role in the entry o
194                                          The reovirus outer capsid protein mu1 forms a lattice surrou
195 highlights a previously unknown role for the reovirus outer capsid protein mu1 in limiting the induct
196                                          The reovirus outer capsid protein mu1 negatively regulates r
197                                          The reovirus outer capsid protein mu1 regulates cell death i
198 highlights a previously unknown role for the reovirus outer capsid protein sigma3 in limiting the ind
199 entified regions or specific residues within reovirus outer capsid proteins that impact the efficienc
200 unknown relationship between two nonadjacent reovirus outer capsid proteins, sigma1 and mu1.
201                 The mammalian orthoreovirus (reovirus) outer capsid is composed of 200 mu1-sigma3 het
202 tif (PBM) in the cytosolic tail of reptilian reovirus p14 FAST protein functions as a novel tribasic
203 l number of proteins needed to form a viable reovirus particle.
204        After attachment to the cell surface, reovirus particles and JAM-A codistribute into each of t
205                                              Reovirus particles are covered with 200 mu1/sigma3 heter
206 e, the sigma1 protein mediates attachment of reovirus particles to host cells via interaction with ce
207 multiple approaches to determine if uncoated reovirus particles, called intermediate subviral particl
208 iously described role for mu1 in influencing reovirus pathogenesis.
209 to controls, demonstrating a role for Bak in reovirus pathogenesis.
210 at carbohydrate binding by sigma1 influences reovirus pathology in the CNS.
211 polyphaga, and Willaertia magna, we followed reovirus persistence (by quantitative reverse transcript
212               Oncolytic viruses (OV) such as reovirus preferentially infect and kill cancer cells.
213                                              Reovirus preferentially kills transformed cells and is i
214 inant reovirus for mechanistic insights into reovirus protein function and structure.
215              We previously reported that the reovirus protein mu2 from strain T1L, but not strain T3D
216  oligodendrocyte glycoprotein (MOG) fused to reovirus protein sigma1 (MOG-psigma1), which activates T
217 identified ITAM sequences in three mammalian reovirus proteins: mu2, sigma2, and lambda2.
218                        The 2-layer capsid of reovirus provides a model system to study the interactio
219 at a nonstructural protein of a novel insect reovirus provides a safe and pivotal channel for virus s
220        We previously engineered an oncolytic reovirus (r2Reovirus) with enhanced infective and cytoto
221       We previously engineered a reassortant reovirus, r2Reovirus, that infects TNBC cells more effic
222  sigma1, and the effect of the antibodies on reovirus receptor engagement.
223 h is demonstrated by studying the process of reovirus release from intracellular vesicles during the
224 s BRAF and PI3K inhibitors, and the anti-RAS reovirus Reolysin(R).
225                                              Reovirus replicates in cytoplasmic viral factories, and
226               After peroral entry into mice, reovirus replicates within the gastrointestinal tract an
227        Moreover, depletion of SRSF2 enhanced reovirus replication and cytopathic effect, suggesting t
228 letion of this cell splicing factor enhances reovirus replication and cytopathic effect.
229            However, JAM-A is dispensable for reovirus replication in the CNS.
230 vide new insights into mechanisms underlying reovirus replication in the respiratory tract and system
231                                              Reovirus replication was also significantly reduced in I
232    Beyond providing mechanistic insight into reovirus replication, our findings also show that reovir
233   To address the role of mRNA capping during reovirus replication, we assessed the benefits of adding
234        Induction of necroptosis by mammalian reovirus requires both type I interferon (IFN)-signaling
235 d to T7 RNA polymerase alone while enhancing reovirus rescue from the current reverse genetics system
236                              NP868R-assisted reovirus rescue will also expedite production of recombi
237 ine fever virus NP868R capping enzyme during reovirus rescue.
238 rus replication, our findings also show that reovirus reverse genetics rescue is enhanced 100-fold by
239 shows promise as a cancer therapy, efficient reovirus reverse genetics rescue will accelerate product
240 rategy for engineering recombinant mammalian reoviruses (rMRVs) to express exogenous polypeptides.
241          Knockdown of sigma3 does not impact reovirus RNA synthesis.
242      We demonstrate here that some mammalian reoviruses, RNA viruses that replicate strictly in the c
243  new virions, we developed a new recombinant reovirus S1 gene that expressed the fluorescent protein
244                     Mammalian orthoreovirus (reovirus) selectively infects and kills transformed cell
245 ontrol cell line (HEK293) were infected with reovirus serotype 3 strain Dearing (T3D) at 0, 0.1, 1, a
246                             It is unclear if reovirus serotypes differentially infect and kill triple
247 fferences in pathogenesis displayed by these reovirus serotypes.
248         Characterization of each recombinant reovirus sheds light on muNS interactions with viral pro
249                                        Since reovirus shows promise as a cancer therapy, efficient re
250 ic force microscopy, we investigated how the reovirus sigma1 attachment protein binds to both alpha-l
251  Comparison with the structure of serotype 3 reovirus sigma1 bound to JAM-A reveals that both sigma1
252 al viral RNA-binding proteins, such as avian reovirus sigmaNS, are essential for virus replication, t
253  We further investigated the determinants of reovirus stability.
254 3D/T1L S4 to investigate the determinants of reovirus stability.
255 components that differentially contribute to reovirus stability.
256 ls new details regarding the determinants of reovirus stability.IMPORTANCE Nonenveloped viruses rely
257                             Infection with a reovirus strain that targets this splicing factor alters
258 ell types and assessed bloodstream spread of reovirus strain type 1 Lang (T1L), which disseminates so
259                   After peroral inoculation, reovirus strain type 1 Lang replicates to high titers in
260              The highest homologies to S1133 reovirus strain were detected in GC1 (~77%) while GC2 to
261 ormed by T3-T1M1, a productively replicating reovirus strain, and contained decreased numbers of comp
262                                          Two reovirus strains that differ in the capacity to bind sia
263  viral infection model that makes use of two reovirus strains that infect the intestine but differ in
264 tion sequencing (NGS), previously unreported reoviruses such as equine encephalosis virus, Wad Medani
265 capping provides nontraditional functions to reovirus, such as promoting assembly and infectious-RNA
266 capping provides nontraditional functions to reovirus, such as promoting assembly and infectious-RNA
267 AM-A but not hematopoietic JAM-A facilitates reovirus T1L bloodstream entry and egress.
268         Indeed, RNA sequencing revealed that reovirus T1L, but not T3D, infection alters the splicing
269                               We generated a reovirus T3D reassortant that carries strain T1L-derived
270 nly exception to this dogma is the fusogenic reoviruses that encode fusion-associated small transmemb
271  To test this idea, we generated recombinant reoviruses that encoded deletions within this loop (Delt
272        In this study, we generated two novel reoviruses that more efficiently infect and kill triple-
273                                          For reovirus, the functional significance of conformational
274 vestigate the anti-cancer killing effects of reovirus therapy combined with protoporphyrin IX (PpIX)-
275                 Candidate genes required for reovirus to cause cell death were highly enriched for si
276 surface expression of JAM-A or attachment of reovirus to cells.
277                                Attachment of reovirus to host cells is mediated by the sigma1 protein
278 operties of sigma1 influence the capacity of reovirus to target specific host tissues and produce dis
279  found that this novel and persistent insect reovirus took advantage of a virus-encoded nonstructural
280 y endosomes with a concomitant impairment of reovirus transit to late endosomes and a delay in reovir
281     To address this question, we use MNV and reovirus, two enteric viruses that replicate in differen
282 y of cancers, but it is unknown if different reovirus types lead to triple-negative breast cancer cel
283 , IFITM3, localizes to late endosomes, where reoviruses undergo proteolytic disassembly; therefore, w
284            Within the endocytic compartment, reovirus undergoes stepwise disassembly, which is follow
285 at the ventral side of adherent cells during reovirus uptake exceed the binding strength of biotin-ne
286          Collectively, our results show that reovirus uses a previously undescribed, membrane-engaged
287                   These results suggest that reovirus uses different capsid components to bind distin
288 st this hypothesis, we engineered a panel of reovirus variants with T3A sigma3 polymorphisms introduc
289 tis virus, measles virus, influenza A virus, reovirus, vesicular stomatitis virus, human immunodefici
290 ements thought to stabilize a single-shelled reovirus virion, suggesting what may be the minimal numb
291                                              Reovirus virions bind to soluble JAM-A and NgR1, while i
292                       In vitro incubation of reovirus virions with high concentration of chymotrypsin
293                                   Incubating reovirus virions with soluble NgR1 neutralizes infectivi
294 veolar endocytosis also reduced infection by reovirus virions.
295 es with varying degrees of susceptibility to reovirus, we found that OV-induced changes in central en
296                        Here, using mammalian reovirus, we highlight the molecular mechanism by which
297                               A total of 265 reoviruses were detected and isolated, 83.3% from tendon
298 FAKV is a naturally occurring single-shelled reovirus with a unique virion architecture that lacks se
299                                              Reovirus with PpIX-mediated photodynamic therapy resulte
300                       Genomes from mammalian reoviruses with 5'pp termini, 5'pp-RNA isolated from yea

 
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